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Patent code US9394289

Compile Data Set for Download or QSAR
Found 44 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238106
PNG
(US9394289, 2)
Show SMILES CN(C)CCOC1(CCOCC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C28H37N5O3/c1-27(2)9-7-20(8-10-27)23-17-21(28(11-14-35-15-12-28)36-16-13-33(3)4)5-6-24(23)32-26(34)25-30-19-22(18-29)31-25/h5-7,17,19H,8-16H2,1-4H3,(H,30,31)(H,32,34)
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Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238129
PNG
(US9394289, 25)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1nc(c[nH]1)C#N)C1(CO)CCOCC1
Show InChI InChI=1S/C25H30N4O3/c1-24(2)7-5-17(6-8-24)20-13-18(25(16-30)9-11-32-12-10-25)3-4-21(20)29-23(31)22-27-15-19(14-26)28-22/h3-5,13,15,30H,6-12,16H2,1-2H3,(H,27,28)(H,29,31)
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Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238109
PNG
(US9394289, 5)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)C1(N)CCOCC1
Show InChI InChI=1S/C24H29N5O2/c1-23(2)7-5-16(6-8-23)19-13-17(24(26)9-11-31-12-10-24)3-4-20(19)29-22(30)21-27-15-18(14-25)28-21/h3-5,13,15H,6-12,26H2,1-2H3,(H,27,28)(H,29,30)
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Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238121
PNG
(US9394289, 17)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1nc(c[nH]1)C#N)C1(CCOCC1)C(O)=O
Show InChI InChI=1S/C25H28N4O4/c1-24(2)7-5-16(6-8-24)19-13-17(25(23(31)32)9-11-33-12-10-25)3-4-20(19)29-22(30)21-27-15-18(14-26)28-21/h3-5,13,15H,6-12H2,1-2H3,(H,27,28)(H,29,30)(H,31,32)
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Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238120
PNG
(US9394289, 16)
Show SMILES COC(=O)C1(CCOCC1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C26H30N4O4/c1-25(2)8-6-17(7-9-25)20-14-18(26(24(32)33-3)10-12-34-13-11-26)4-5-21(20)30-23(31)22-28-16-19(15-27)29-22/h4-6,14,16H,7-13H2,1-3H3,(H,28,29)(H,30,31)
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Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238111
PNG
(US9394289, 7)
Show SMILES CN(C)C1(CCOCC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C26H33N5O2/c1-25(2)9-7-18(8-10-25)21-15-19(26(31(3)4)11-13-33-14-12-26)5-6-22(21)30-24(32)23-28-17-20(16-27)29-23/h5-7,15,17H,8-14H2,1-4H3,(H,28,29)(H,30,32)
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Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238105
PNG
(US9394289, 1)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)C1(O)CCOCC1
Show InChI InChI=1S/C24H28N4O3/c1-23(2)7-5-16(6-8-23)19-13-17(24(30)9-11-31-12-10-24)3-4-20(19)28-22(29)21-26-15-18(14-25)27-21/h3-5,13,15,30H,6-12H2,1-2H3,(H,26,27)(H,28,29)
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Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238138
PNG
(US9394289, 35)
Show SMILES CC(=O)N1CCC(O)(CC1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C26H31N5O3/c1-17(32)31-12-10-26(34,11-13-31)19-4-5-22(30-24(33)23-28-16-20(15-27)29-23)21(14-19)18-6-8-25(2,3)9-7-18/h4-6,14,16,34H,7-13H2,1-3H3,(H,28,29)(H,30,33)
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Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238128
PNG
(US9394289, 24)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1nc(c[nH]1)C#N)C1(CCOCC1)C(N)=O
Show InChI InChI=1S/C25H29N5O3/c1-24(2)7-5-16(6-8-24)19-13-17(25(23(27)32)9-11-33-12-10-25)3-4-20(19)30-22(31)21-28-15-18(14-26)29-21/h3-5,13,15H,6-12H2,1-2H3,(H2,27,32)(H,28,29)(H,30,31)
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Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238117
PNG
(US9394289, 13)
Show SMILES CC(=O)N1CCC(N)(CC1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C26H32N6O2/c1-17(33)32-12-10-26(28,11-13-32)19-4-5-22(31-24(34)23-29-16-20(15-27)30-23)21(14-19)18-6-8-25(2,3)9-7-18/h4-6,14,16H,7-13,28H2,1-3H3,(H,29,30)(H,31,34)
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Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238126
PNG
(US9394289, 22)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1nc(c[nH]1)C#N)C1(CCOCC1)c1nn[nH]n1
Show InChI InChI=1S/C25H28N8O2/c1-24(2)7-5-16(6-8-24)19-13-17(25(9-11-35-12-10-25)23-30-32-33-31-23)3-4-20(19)29-22(34)21-27-15-18(14-26)28-21/h3-5,13,15H,6-12H2,1-2H3,(H,27,28)(H,29,34)(H,30,31,32,33)
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Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238116
PNG
(US9394289, 12)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1nc(c[nH]1)C#N)C1(O)CCS(=O)(=O)CC1
Show InChI InChI=1S/C24H28N4O4S/c1-23(2)7-5-16(6-8-23)19-13-17(24(30)9-11-33(31,32)12-10-24)3-4-20(19)28-22(29)21-26-15-18(14-25)27-21/h3-5,13,15,30H,6-12H2,1-2H3,(H,26,27)(H,28,29)
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Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238139
PNG
(US9394289, 87)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1nc(c[nH]1)C#N)C1(CCS(=O)(=O)CC1)C#N
Show InChI InChI=1S/C25H27N5O3S/c1-24(2)7-5-17(6-8-24)20-13-18(25(16-27)9-11-34(32,33)12-10-25)3-4-21(20)30-23(31)22-28-15-19(14-26)29-22/h3-5,13,15H,6-12H2,1-2H3,(H,28,29)(H,30,31)
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Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238148
PNG
(US9394289, 31)
Show SMILES C[C@H]1C[C@](O)(C[C@@H](C)O1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C26H32N4O3/c1-16-12-26(32,13-17(2)33-16)19-5-6-22(30-24(31)23-28-15-20(14-27)29-23)21(11-19)18-7-9-25(3,4)10-8-18/h5-7,11,15-17,32H,8-10,12-13H2,1-4H3,(H,28,29)(H,30,31)/t16-,17+,26-
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Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238137
PNG
(US9394289, 34)
Show SMILES CS(=O)(=O)C1(CCOCC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C23H26N4O4S/c1-32(29,30)23(9-11-31-12-10-23)17-7-8-20(19(13-17)16-5-3-2-4-6-16)27-22(28)21-25-15-18(14-24)26-21/h5,7-8,13,15H,2-4,6,9-12H2,1H3,(H,25,26)(H,27,28)
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Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238110
PNG
(US9394289, 6)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)C1(CCOCC1)N1CCOCC1
Show InChI InChI=1S/C28H35N5O3/c1-27(2)7-5-20(6-8-27)23-17-21(28(9-13-35-14-10-28)33-11-15-36-16-12-33)3-4-24(23)32-26(34)25-30-19-22(18-29)31-25/h3-5,17,19H,6-16H2,1-2H3,(H,30,31)(H,32,34)
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Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238133
PNG
(US9394289, 29)
Show SMILES CN(C)C(=O)C1(CCOCC1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C27H33N5O3/c1-26(2)9-7-18(8-10-26)21-15-19(27(25(34)32(3)4)11-13-35-14-12-27)5-6-22(21)31-24(33)23-29-17-20(16-28)30-23/h5-7,15,17H,8-14H2,1-4H3,(H,29,30)(H,31,33)
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Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238125
PNG
(US9394289, 21)
Show SMILES O=C(Nc1ccc(cc1C1=CCCCC1)C1(CN2CCOCC2)CCOCC1)c1nc(c[nH]1)C#N
Show InChI InChI=1S/C27H33N5O3/c28-17-22-18-29-25(30-22)26(33)31-24-7-6-21(16-23(24)20-4-2-1-3-5-20)27(8-12-34-13-9-27)19-32-10-14-35-15-11-32/h4,6-7,16,18H,1-3,5,8-15,19H2,(H,29,30)(H,31,33)
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Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238107
PNG
(US9394289, 3)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)C1(CCOCC1)OCC(O)=O
Show InChI InChI=1S/C26H30N4O5/c1-25(2)7-5-17(6-8-25)20-13-18(26(35-16-22(31)32)9-11-34-12-10-26)3-4-21(20)30-24(33)23-28-15-19(14-27)29-23/h3-5,13,15H,6-12,16H2,1-2H3,(H,28,29)(H,30,33)(H,31,32)
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Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238123
PNG
(US9394289, 19)
Show SMILES NC(=O)C1(CCOCC1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C23H25N5O3/c24-13-17-14-26-20(27-17)21(29)28-19-7-6-16(12-18(19)15-4-2-1-3-5-15)23(22(25)30)8-10-31-11-9-23/h4,6-7,12,14H,1-3,5,8-11H2,(H2,25,30)(H,26,27)(H,28,29)
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Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238124
PNG
(US9394289, 20)
Show SMILES OCC1(CCOCC1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C23H26N4O3/c24-13-18-14-25-21(26-18)22(29)27-20-7-6-17(23(15-28)8-10-30-11-9-23)12-19(20)16-4-2-1-3-5-16/h4,6-7,12,14,28H,1-3,5,8-11,15H2,(H,25,26)(H,27,29)
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Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238108
PNG
(US9394289, 4)
Show SMILES COCCNC1(CCOCC1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C27H35N5O3/c1-26(2)8-6-19(7-9-26)22-16-20(27(30-12-15-34-3)10-13-35-14-11-27)4-5-23(22)32-25(33)24-29-18-21(17-28)31-24/h4-6,16,18,30H,7-15H2,1-3H3,(H,29,31)(H,32,33)
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Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238113
PNG
(US9394289, 9)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)C1(CCOCC1)N1CCNCC1
Show InChI InChI=1S/C28H36N6O2/c1-27(2)7-5-20(6-8-27)23-17-21(28(9-15-36-16-10-28)34-13-11-30-12-14-34)3-4-24(23)33-26(35)25-31-19-22(18-29)32-25/h3-5,17,19,30H,6-16H2,1-2H3,(H,31,32)(H,33,35)
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Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238144
PNG
(US9394289, 92)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1nc(c[nH]1)C#N)C1(O)CC2CCC(C1)O2
Show InChI InChI=1S/C26H30N4O3/c1-25(2)9-7-16(8-10-25)21-11-17(26(32)12-19-4-5-20(13-26)33-19)3-6-22(21)30-24(31)23-28-15-18(14-27)29-23/h3,6-7,11,15,19-20,32H,4-5,8-10,12-13H2,1-2H3,(H,28,29)(H,30,31)
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Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238140
PNG
(US9394289, 88)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1nc(c[nH]1)C#N)C1(O)CC(C)(C)OC(C)(C)C1
Show InChI InChI=1S/C28H36N4O3/c1-25(2)11-9-18(10-12-25)21-13-19(28(34)16-26(3,4)35-27(5,6)17-28)7-8-22(21)32-24(33)23-30-15-20(14-29)31-23/h7-9,13,15,34H,10-12,16-17H2,1-6H3,(H,30,31)(H,32,33)
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Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238119
PNG
(US9394289, 15)
Show SMILES OC1(CCS(=O)(=O)CC1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C22H24N4O4S/c23-13-17-14-24-20(25-17)21(27)26-19-7-6-16(12-18(19)15-4-2-1-3-5-15)22(28)8-10-31(29,30)11-9-22/h4,6-7,12,14,28H,1-3,5,8-11H2,(H,24,25)(H,26,27)
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Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238131
PNG
(US9394289, 27)
Show SMILES OC1(CCOCC1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C22H24N4O3/c23-13-17-14-24-20(25-17)21(27)26-19-7-6-16(22(28)8-10-29-11-9-22)12-18(19)15-4-2-1-3-5-15/h4,6-7,12,14,28H,1-3,5,8-11H2,(H,24,25)(H,26,27)
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Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238115
PNG
(US9394289, 11)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1nc(c[nH]1)C#N)C1(O)CCSCC1
Show InChI InChI=1S/C24H28N4O2S/c1-23(2)7-5-16(6-8-23)19-13-17(24(30)9-11-31-12-10-24)3-4-20(19)28-22(29)21-26-15-18(14-25)27-21/h3-5,13,15,30H,6-12H2,1-2H3,(H,26,27)(H,28,29)
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Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238145
PNG
(US9394289, 93)
Show SMILES CC12CCC(C)(CC(O)(C1)c1ccc(NC(=O)c3nc(c[nH]3)C#N)c(c1)C1=CCC(C)(C)CC1)O2
Show InChI InChI=1S/C28H34N4O3/c1-25(2)9-7-18(8-10-25)21-13-19(28(34)16-26(3)11-12-27(4,17-28)35-26)5-6-22(21)32-24(33)23-30-15-20(14-29)31-23/h5-7,13,15,34H,8-12,16-17H2,1-4H3,(H,30,31)(H,32,33)
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Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238130
PNG
(US9394289, 26)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1nc(c[nH]1)C#N)C1(CN2CCOCC2)CCOCC1
Show InChI InChI=1S/C29H37N5O3/c1-28(2)7-5-21(6-8-28)24-17-22(3-4-25(24)33-27(35)26-31-19-23(18-30)32-26)29(9-13-36-14-10-29)20-34-11-15-37-16-12-34/h3-5,17,19H,6-16,20H2,1-2H3,(H,31,32)(H,33,35)
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Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238135
PNG
(US9394289, 32)
Show SMILES C[C@H]1CC(O)(C[C@@H](C)O1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(n1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C25H31N5O3/c1-15-11-25(32,12-16(2)33-15)20-6-5-19(29-23(31)22-27-14-18(13-26)28-22)21(30-20)17-7-9-24(3,4)10-8-17/h5-7,14-16,32H,8-12H2,1-4H3,(H,27,28)(H,29,31)/t15-,16+,25?
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Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238134
PNG
(US9394289, 30)
Show SMILES C[C@H]1C[C@@](O)(C[C@@H](C)O1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C26H32N4O3/c1-16-12-26(32,13-17(2)33-16)19-5-6-22(30-24(31)23-28-15-20(14-27)29-23)21(11-19)18-7-9-25(3,4)10-8-18/h5-7,11,15-17,32H,8-10,12-13H2,1-4H3,(H,28,29)(H,30,31)/t16-,17+,26+
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Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238122
PNG
(US9394289, 18)
Show SMILES OC(=O)C1(CCOCC1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C23H24N4O4/c24-13-17-14-25-20(26-17)21(28)27-19-7-6-16(12-18(19)15-4-2-1-3-5-15)23(22(29)30)8-10-31-11-9-23/h4,6-7,12,14H,1-3,5,8-11H2,(H,25,26)(H,27,28)(H,29,30)
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Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238136
PNG
(US9394289, 33)
Show SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)C1(O)CCOCC1
Show InChI InChI=1S/C23H27N5O3/c1-22(2)7-5-15(6-8-22)19-17(27-21(29)20-25-14-16(13-24)26-20)3-4-18(28-19)23(30)9-11-31-12-10-23/h3-5,14,30H,6-12H2,1-2H3,(H,25,26)(H,27,29)
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Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238118
PNG
(US9394289, 14)
Show SMILES OC1(CCSCC1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C22H24N4O2S/c23-13-17-14-24-20(25-17)21(27)26-19-7-6-16(22(28)8-10-29-11-9-22)12-18(19)15-4-2-1-3-5-15/h4,6-7,12,14,28H,1-3,5,8-11H2,(H,24,25)(H,26,27)
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Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238112
PNG
(US9394289, 8)
Show SMILES CN1CCN(CC1)C1(CCOCC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C29H38N6O2/c1-28(2)8-6-21(7-9-28)24-18-22(4-5-25(24)33-27(36)26-31-20-23(19-30)32-26)29(10-16-37-17-11-29)35-14-12-34(3)13-15-35/h4-6,18,20H,7-17H2,1-3H3,(H,31,32)(H,33,36)
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Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238127
PNG
(US9394289, 23)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1cc(c[nH]1)C#N)C1(CCOCC1)C(O)=O
Show InChI InChI=1S/C26H29N3O4/c1-25(2)7-5-18(6-8-25)20-14-19(26(24(31)32)9-11-33-12-10-26)3-4-21(20)29-23(30)22-13-17(15-27)16-28-22/h3-5,13-14,16,28H,6-12H2,1-2H3,(H,29,30)(H,31,32)
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Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238142
PNG
(US9394289, 90)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1nc(c[nH]1)C#N)C1(O)CCN(CC(F)(F)F)CC1
Show InChI InChI=1S/C26H30F3N5O2/c1-24(2)7-5-17(6-8-24)20-13-18(25(36)9-11-34(12-10-25)16-26(27,28)29)3-4-21(20)33-23(35)22-31-15-19(14-30)32-22/h3-5,13,15,36H,6-12,16H2,1-2H3,(H,31,32)(H,33,35)
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Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238114
PNG
(US9394289, 10)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)C1(CCOCC1)N1CCN(CC(O)=O)CC1
Show InChI InChI=1S/C30H38N6O4/c1-29(2)7-5-21(6-8-29)24-17-22(3-4-25(24)34-28(39)27-32-19-23(18-31)33-27)30(9-15-40-16-10-30)36-13-11-35(12-14-36)20-26(37)38/h3-5,17,19H,6-16,20H2,1-2H3,(H,32,33)(H,34,39)(H,37,38)
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Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238132
PNG
(US9394289, 28)
Show SMILES CN(C)C(=O)C1(CCOCC1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C25H29N5O3/c1-30(2)24(32)25(10-12-33-13-11-25)18-8-9-21(20(14-18)17-6-4-3-5-7-17)29-23(31)22-27-16-19(15-26)28-22/h6,8-9,14,16H,3-5,7,10-13H2,1-2H3,(H,27,28)(H,29,31)
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Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238141
PNG
(US9394289, 89)
Show SMILES CON1C(C)(C)CC(O)(CC1(C)C)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C29H39N5O3/c1-26(2)12-10-19(11-13-26)22-14-20(29(36)17-27(3,4)34(37-7)28(5,6)18-29)8-9-23(22)33-25(35)24-31-16-21(15-30)32-24/h8-10,14,16,36H,11-13,17-18H2,1-7H3,(H,31,32)(H,33,35)
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Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238147
PNG
(US9394289, 95)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1nc(c[nH]1)C#N)C1(CC(C)(C)OC(C)(C)C1)C#N
Show InChI InChI=1S/C29H35N5O2/c1-26(2)11-9-19(10-12-26)22-13-20(29(18-31)16-27(3,4)36-28(5,6)17-29)7-8-23(22)34-25(35)24-32-15-21(14-30)33-24/h7-9,13,15H,10-12,16-17H2,1-6H3,(H,32,33)(H,34,35)
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MMDB

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UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 26n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238146
PNG
(US9394289, 94)
Show SMILES C[C@@]12CC[C@](C)(CC(C1)(C#N)c1ccc(NC(=O)c3nc(c[nH]3)C#N)c(c1)C1=CCC(C)(C)CC1)O2
Show InChI InChI=1S/C29H33N5O2/c1-26(2)9-7-19(8-10-26)22-13-20(29(18-31)16-27(3)11-12-28(4,17-29)36-27)5-6-23(22)34-25(35)24-32-15-21(14-30)33-24/h5-7,13,15H,8-12,16-17H2,1-4H3,(H,32,33)(H,34,35)/t27-,28-/m1/s1
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n/an/a 82n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238143
PNG
(US9394289, 91)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1nc(c[nH]1)C#N)C1(O)CC(C)(C)N(CC(F)(F)F)C(C)(C)C1
Show InChI InChI=1S/C30H38F3N5O2/c1-26(2)11-9-19(10-12-26)22-13-20(7-8-23(22)37-25(39)24-35-15-21(14-34)36-24)29(40)16-27(3,4)38(18-30(31,32)33)28(5,6)17-29/h7-9,13,15,40H,10-12,16-18H2,1-6H3,(H,35,36)(H,37,39)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
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PC cid
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UniChem
US Patent
n/an/a 210n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%