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Patent code US9394309

Compile Data Set for Download or QSAR
Found 198 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239621
PNG
(US9394309, 147 | US9394309, 74)
Show SMILES Cc1cc(C)c(cc1NC(=O)c1cc(cc(c1)S(F)(F)(F)(F)F)C#N)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C26H19F5N6OS/c1-16-8-17(2)24(36-6-7-37-25(36)13-23(35-37)19-4-3-5-33-15-19)12-22(16)34-26(38)20-9-18(14-32)10-21(11-20)39(27,28,29,30)31/h3-13,15H,1-2H3,(H,34,38)
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n/an/a 0.200n/an/an/an/an/an/a



Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239557
PNG
(US9394309, 10)
Show SMILES Cc1cn(-c2cc(NC(=O)c3cc(cc(c3)S(F)(F)(F)(F)F)N3CCNCC3)ccc2C)c2cc(nn12)-c1cn[nH]c1
Show InChI InChI=1S/C27H27F5N8OS/c1-17-3-4-21(11-25(17)39-16-18(2)40-26(39)13-24(37-40)20-14-34-35-15-20)36-27(41)19-9-22(38-7-5-33-6-8-38)12-23(10-19)42(28,29,30,31)32/h3-4,9-16,33H,5-8H2,1-2H3,(H,34,35)(H,36,41)
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Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239696
PNG
(US9394309, 153)
Show SMILES Cc1cc(C)c(cc1NC(=O)c1cc(CC(N)=O)cc(c1)S(F)(F)(F)(F)F)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C27H23F5N6O2S/c1-16-8-17(2)24(37-6-7-38-26(37)14-23(36-38)19-4-3-5-34-15-19)13-22(16)35-27(40)20-9-18(11-25(33)39)10-21(12-20)41(28,29,30,31)32/h3-10,12-15H,11H2,1-2H3,(H2,33,39)(H,35,40)
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Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239596
PNG
(US9394309, 49)
Show SMILES Cc1ccc(NC(=O)c2cc(cc(c2)C(C)(C)O)C(C)(C)C)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C31H33N5O2/c1-20-9-10-25(33-29(37)22-14-23(30(2,3)4)16-24(15-22)31(5,6)38)17-27(20)35-12-13-36-28(35)18-26(34-36)21-8-7-11-32-19-21/h7-19,38H,1-6H3,(H,33,37)
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Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239548
PNG
(US9394309, 1)
Show SMILES Cc1ccc(NC(=O)c2cc(cc(c2)S(F)(F)(F)(F)F)N2CCNCC2)cc1-n1ccn2nc(cc12)-c1cn[nH]c1
Show InChI InChI=1S/C26H25F5N8OS/c1-17-2-3-20(12-24(17)38-8-9-39-25(38)14-23(36-39)19-15-33-34-16-19)35-26(40)18-10-21(37-6-4-32-5-7-37)13-22(11-18)41(27,28,29,30)31/h2-3,8-16,32H,4-7H2,1H3,(H,33,34)(H,35,40)
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Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239564
PNG
(US9394309, 17)
Show SMILES Cc1ccc(NC(=O)c2cc(cc(c2)S(F)(F)(F)(F)F)N2CCNCC2)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C28H26F5N7OS/c1-19-4-5-22(15-26(19)39-11-12-40-27(39)17-25(37-40)20-3-2-6-35-18-20)36-28(41)21-13-23(38-9-7-34-8-10-38)16-24(14-21)42(29,30,31,32)33/h2-6,11-18,34H,7-10H2,1H3,(H,36,41)
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Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239595
PNG
(US9394309, 48)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(C)(C)C)C(=O)Nc1ccc(C)c(c1)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C33H37N7O/c1-23-8-9-27(20-30(23)39-15-16-40-31(39)21-29(36-40)24-7-6-10-34-22-24)35-32(41)25-17-26(33(2,3)4)19-28(18-25)38-13-11-37(5)12-14-38/h6-10,15-22H,11-14H2,1-5H3,(H,35,41)
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Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239712
PNG
(US9394309, 171)
Show SMILES Cc1cc(C)c(cc1NC(=O)c1cc(cc(c1)S(F)(F)(F)(F)F)C#N)-n1ccn2nc(cc12)-c1cccnn1
Show InChI InChI=1S/C25H18F5N7OS/c1-15-8-16(2)23(36-6-7-37-24(36)13-22(35-37)20-4-3-5-32-34-20)12-21(15)33-25(38)18-9-17(14-31)10-19(11-18)39(26,27,28,29)30/h3-13H,1-2H3,(H,33,38)
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US Patent


Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239708
PNG
(US9394309, 166)
Show SMILES Cc1cc(C)c(cc1NC(=O)c1cc(cc(c1)S(F)(F)(F)(F)F)C#N)-n1ccn2nc(cc12)-c1cncnc1
Show InChI InChI=1S/C25H18F5N7OS/c1-15-5-16(2)23(36-3-4-37-24(36)10-22(35-37)19-12-32-14-33-13-19)9-21(15)34-25(38)18-6-17(11-31)7-20(8-18)39(26,27,28,29)30/h3-10,12-14H,1-2H3,(H,34,38)
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Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239558
PNG
(US9394309, 11)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)S(F)(F)(F)(F)F)C(=O)Nc1ccc(C)c(c1)-n1cc(C)n2nc(cc12)-c1cn[nH]c1
Show InChI InChI=1S/C28H29F5N8OS/c1-18-4-5-22(12-26(18)40-17-19(2)41-27(40)14-25(37-41)21-15-34-35-16-21)36-28(42)20-10-23(39-8-6-38(3)7-9-39)13-24(11-20)43(29,30,31,32)33/h4-5,10-17H,6-9H2,1-3H3,(H,34,35)(H,36,42)
PDB

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Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239658
PNG
(US9394309, 114)
Show SMILES Cc1cc(C)c(cc1NC(=O)c1cc(cc(c1)C(C)(C)C)C#N)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C30H28N6O/c1-19-11-20(2)27(35-9-10-36-28(35)16-26(34-36)22-7-6-8-32-18-22)15-25(19)33-29(37)23-12-21(17-31)13-24(14-23)30(3,4)5/h6-16,18H,1-5H3,(H,33,37)
PDB

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Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239620
PNG
(US9394309, 73)
Show SMILES Cc1cc(C)c(cc1NC(=O)c1cccc(c1)S(F)(F)(F)(F)F)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C25H20F5N5OS/c1-16-11-17(2)23(34-9-10-35-24(34)14-22(33-35)19-6-4-8-31-15-19)13-21(16)32-25(36)18-5-3-7-20(12-18)37(26,27,28,29)30/h3-15H,1-2H3,(H,32,36)
PDB

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Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239570
PNG
(US9394309, 23)
Show SMILES Cc1ccc(NC(=O)c2cc(OCCCN)cc(c2)S(F)(F)(F)(F)F)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C27H25F5N6O2S/c1-18-5-6-21(14-25(18)37-9-10-38-26(37)16-24(36-38)19-4-2-8-34-17-19)35-27(39)20-12-22(40-11-3-7-33)15-23(13-20)41(28,29,30,31)32/h2,4-6,8-10,12-17H,3,7,11,33H2,1H3,(H,35,39)
PDB

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Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239583
PNG
(US9394309, 36)
Show SMILES CN1CCN(Cc2cc(cc(c2)S(F)(F)(F)(F)F)C(=O)Nc2ccc(C)c(c2)-n2ccn3nc(cc23)-c2cccnc2)CC1
Show InChI InChI=1S/C30H30F5N7OS/c1-21-5-6-25(17-28(21)41-12-13-42-29(41)18-27(38-42)23-4-3-7-36-19-23)37-30(43)24-14-22(20-40-10-8-39(2)9-11-40)15-26(16-24)44(31,32,33,34)35/h3-7,12-19H,8-11,20H2,1-2H3,(H,37,43)
PDB

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Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239594
PNG
(US9394309, 47)
Show SMILES Cc1nccn1-c1cc(cc(c1)C(C)(C)C)C(=O)Nc1ccc(C)c(c1)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C32H31N7O/c1-21-8-9-26(18-29(21)38-13-14-39-30(38)19-28(36-39)23-7-6-10-33-20-23)35-31(40)24-15-25(32(3,4)5)17-27(16-24)37-12-11-34-22(37)2/h6-20H,1-5H3,(H,35,40)
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Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239695
PNG
(US9394309, 152)
Show SMILES COC(=O)Cc1cc(cc(c1)S(F)(F)(F)(F)F)C(=O)Nc1cc(c(C)cc1C)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C28H24F5N5O3S/c1-17-9-18(2)25(37-7-8-38-26(37)15-24(36-38)20-5-4-6-34-16-20)14-23(17)35-28(40)21-10-19(12-27(39)41-3)11-22(13-21)42(29,30,31,32)33/h4-11,13-16H,12H2,1-3H3,(H,35,40)
PDB

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Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239661
PNG
(US9394309, 118)
Show SMILES Cc1cc(F)c(NC(=O)c2cc(cc(c2)C(C)(C)C)C#N)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C29H25FN6O/c1-18-10-23(30)25(33-28(37)21-11-19(16-31)12-22(13-21)29(2,3)4)14-26(18)35-8-9-36-27(35)15-24(34-36)20-6-5-7-32-17-20/h5-15,17H,1-4H3,(H,33,37)
PDB

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US Patent


Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239579
PNG
(US9394309, 32)
Show SMILES Cc1ccc(NC(=O)c2cc(cc(c2)S(F)(F)(F)(F)F)C(C)(C)O)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C27H24F5N5O2S/c1-17-6-7-21(14-24(17)36-9-10-37-25(36)15-23(35-37)18-5-4-8-33-16-18)34-26(38)19-11-20(27(2,3)39)13-22(12-19)40(28,29,30,31)32/h4-16,39H,1-3H3,(H,34,38)
PDB

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Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239706
PNG
(US9394309, 164)
Show SMILES Cc1cc(C)c(cc1NC(=O)c1cccc(c1)S(F)(F)(F)(F)F)-n1ccn2nc(cc12)-c1cncnc1
Show InChI InChI=1S/C24H19F5N6OS/c1-15-8-16(2)22(34-6-7-35-23(34)11-21(33-35)18-12-30-14-31-13-18)10-20(15)32-24(36)17-4-3-5-19(9-17)37(25,26,27,28)29/h3-14H,1-2H3,(H,32,36)
PDB

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Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239584
PNG
(US9394309, 37)
Show SMILES Cc1ccc(NC(=O)c2cc(cc(c2)S(F)(F)(F)(F)F)C2(O)CNC2)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C27H23F5N6O2S/c1-17-4-5-21(12-24(17)37-7-8-38-25(37)13-23(36-38)18-3-2-6-33-14-18)35-26(39)19-9-20(27(40)15-34-16-27)11-22(10-19)41(28,29,30,31)32/h2-14,34,40H,15-16H2,1H3,(H,35,39)
PDB

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Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239561
PNG
(US9394309, 14)
Show SMILES Cc1cn(-c2cc(NC(=O)c3cc(cc(c3)C(F)(F)F)-n3ccnc3C)ccc2C)c2cc(nn12)-c1cn[nH]c1
Show InChI InChI=1S/C28H23F3N8O/c1-16-4-5-22(11-25(16)38-15-17(2)39-26(38)12-24(36-39)20-13-33-34-14-20)35-27(40)19-8-21(28(29,30)31)10-23(9-19)37-7-6-32-18(37)3/h4-15H,1-3H3,(H,33,34)(H,35,40)
PDB

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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239697
PNG
(US9394309, 154)
Show SMILES Cc1cc(C)c(cc1NC(=O)c1cc(CC(C)(C)O)cc(c1)S(F)(F)(F)(F)F)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C29H28F5N5O2S/c1-18-10-19(2)26(38-8-9-39-27(38)15-25(37-39)21-6-5-7-35-17-21)14-24(18)36-28(40)22-11-20(16-29(3,4)41)12-23(13-22)42(30,31,32,33)34/h5-15,17,41H,16H2,1-4H3,(H,36,40)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239691
PNG
(US9394309, 148)
Show SMILES Cc1cc(C)c(cc1NC(=O)c1cc(cc(c1)S(F)(F)(F)(F)F)C(C)(C)O)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C28H26F5N5O2S/c1-17-10-18(2)25(37-8-9-38-26(37)15-24(36-38)19-6-5-7-34-16-19)14-23(17)35-27(39)20-11-21(28(3,4)40)13-22(12-20)41(29,30,31,32)33/h5-16,40H,1-4H3,(H,35,39)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239653
PNG
(US9394309, 109)
Show SMILES Cc1cc(C)c(cc1NC(=O)c1cc(Br)cc(c1)S(F)(F)(F)(F)F)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C25H19BrF5N5OS/c1-15-8-16(2)23(35-6-7-36-24(35)13-22(34-36)17-4-3-5-32-14-17)12-21(15)33-25(37)18-9-19(26)11-20(10-18)38(27,28,29,30)31/h3-14H,1-2H3,(H,33,37)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239582
PNG
(US9394309, 35)
Show SMILES Cc1ccc(NC(=O)c2cc(CN3CCNCC3)cc(c2)S(F)(F)(F)(F)F)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C29H28F5N7OS/c1-20-4-5-24(16-27(20)40-11-12-41-28(40)17-26(38-41)22-3-2-6-36-18-22)37-29(42)23-13-21(19-39-9-7-35-8-10-39)14-25(15-23)43(30,31,32,33)34/h2-6,11-18,35H,7-10,19H2,1H3,(H,37,42)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239621
PNG
(US9394309, 147 | US9394309, 74)
Show SMILES Cc1cc(C)c(cc1NC(=O)c1cc(cc(c1)S(F)(F)(F)(F)F)C#N)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C26H19F5N6OS/c1-16-8-17(2)24(36-6-7-37-25(36)13-23(35-37)19-4-3-5-33-15-19)12-22(16)34-26(38)20-9-18(14-32)10-21(11-20)39(27,28,29,30)31/h3-13,15H,1-2H3,(H,34,38)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239700
PNG
(US9394309, 157)
Show SMILES Cc1cc(Cl)c(cc1NC(=O)c1cccc(c1)S(F)(F)(F)(F)F)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C24H17ClF5N5OS/c1-15-10-19(25)22(34-8-9-35-23(34)13-21(33-35)17-5-3-7-31-14-17)12-20(15)32-24(36)16-4-2-6-18(11-16)37(26,27,28,29)30/h2-14H,1H3,(H,32,36)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239683
PNG
(US9394309, 140)
Show SMILES Cc1cc(C)c(cc1NC(=O)c1cccc(c1)C1(C)COC1)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C29H27N5O2/c1-19-12-20(2)26(33-10-11-34-27(33)15-25(32-34)22-7-5-9-30-16-22)14-24(19)31-28(35)21-6-4-8-23(13-21)29(3)17-36-18-29/h4-16H,17-18H2,1-3H3,(H,31,35)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239622
PNG
(US9394309, 75)
Show SMILES Cc1cc(F)c(NC(=O)c2cc(cc(c2)S(F)(F)(F)(F)F)C#N)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C25H16F6N6OS/c1-15-7-20(26)22(34-25(38)18-8-16(13-32)9-19(10-18)39(27,28,29,30)31)11-23(15)36-5-6-37-24(36)12-21(35-37)17-3-2-4-33-14-17/h2-12,14H,1H3,(H,34,38)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239660
PNG
(US9394309, 116)
Show SMILES Cc1cc(C)c(cc1NC(=O)c1cc(nc(c1)C(C)(C)C)C#N)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C29H27N7O/c1-18-11-19(2)25(35-9-10-36-27(35)15-24(34-36)20-7-6-8-31-17-20)14-23(18)33-28(37)21-12-22(16-30)32-26(13-21)29(3,4)5/h6-15,17H,1-5H3,(H,33,37)
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Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239587
PNG
(US9394309, 40)
Show SMILES Cc1nccn1-c1cc(cc(c1)C(F)(F)F)C(=O)Nc1ccc(C)c(c1)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C29H22F3N7O/c1-18-5-6-23(15-26(18)38-10-11-39-27(38)16-25(36-39)20-4-3-7-33-17-20)35-28(40)21-12-22(29(30,31)32)14-24(13-21)37-9-8-34-19(37)2/h3-17H,1-2H3,(H,35,40)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239682
PNG
(US9394309, 139)
Show SMILES Cc1cc(C)c(cc1NC(=O)c1cccc(c1)C(C)(C)C(F)(F)F)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C29H26F3N5O/c1-18-13-19(2)25(36-11-12-37-26(36)16-24(35-37)21-8-6-10-33-17-21)15-23(18)34-27(38)20-7-5-9-22(14-20)28(3,4)29(30,31)32/h5-17H,1-4H3,(H,34,38)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239651
PNG
(US9394309, 107)
Show SMILES Cc1cc(C)c(cc1NC(=O)c1cc(F)cc(c1)S(F)(F)(F)(F)F)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C25H19F6N5OS/c1-15-8-16(2)23(35-6-7-36-24(35)13-22(34-36)17-4-3-5-32-14-17)12-21(15)33-25(37)18-9-19(26)11-20(10-18)38(27,28,29,30)31/h3-14H,1-2H3,(H,33,37)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239569
PNG
(US9394309, 22)
Show SMILES Cc1ccc(NC(=O)c2cc(OCCN)cc(c2)S(F)(F)(F)(F)F)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C26H23F5N6O2S/c1-17-4-5-20(13-24(17)36-8-9-37-25(36)15-23(35-37)18-3-2-7-33-16-18)34-26(38)19-11-21(39-10-6-32)14-22(12-19)40(27,28,29,30)31/h2-5,7-9,11-16H,6,10,32H2,1H3,(H,34,38)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239687
PNG
(US9394309, 144)
Show SMILES Cc1cc(C)c(cc1NC(=O)c1cc(cc(c1)S(F)(F)(F)(F)F)N1CCC(CC1)C#N)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C31H28F5N7OS/c1-20-12-21(2)29(42-10-11-43-30(42)17-28(40-43)23-4-3-7-38-19-23)16-27(20)39-31(44)24-13-25(41-8-5-22(18-37)6-9-41)15-26(14-24)45(32,33,34,35)36/h3-4,7,10-17,19,22H,5-6,8-9H2,1-2H3,(H,39,44)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239621
PNG
(US9394309, 147 | US9394309, 74)
Show SMILES Cc1cc(C)c(cc1NC(=O)c1cc(cc(c1)S(F)(F)(F)(F)F)C#N)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C26H19F5N6OS/c1-16-8-17(2)24(36-6-7-37-25(36)13-23(35-37)19-4-3-5-33-15-19)12-22(16)34-26(38)20-9-18(14-32)10-21(11-20)39(27,28,29,30)31/h3-13,15H,1-2H3,(H,34,38)
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For measuring the autophosphorylation of the endogenous Tie2 receptor in the cell lysates prepared, a self-prepared anti-Tie2 antibody directed again...


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Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239657
PNG
(US9394309, 113)
Show SMILES Cc1cc(C)c(cc1NC(=O)c1cc(Br)cc(c1)C(C)(C)C)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C29H28BrN5O/c1-18-11-19(2)26(34-9-10-35-27(34)16-25(33-35)20-7-6-8-31-17-20)15-24(18)32-28(36)21-12-22(29(3,4)5)14-23(30)13-21/h6-17H,1-5H3,(H,32,36)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239551
PNG
(US9394309, 4)
Show SMILES Cc1ccc(NC(=O)c2cc(cc(c2)S(F)(F)(F)(F)F)C(C)(C)O)cc1-n1ccn2nc(cc12)-c1cn[nH]c1
Show InChI InChI=1S/C25H23F5N6O2S/c1-15-4-5-19(11-22(15)35-6-7-36-23(35)12-21(34-36)17-13-31-32-14-17)33-24(37)16-8-18(25(2,3)38)10-20(9-16)39(26,27,28,29)30/h4-14,38H,1-3H3,(H,31,32)(H,33,37)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239689
PNG
(US9394309, 146)
Show SMILES COC1CN(C1)c1cc(cc(c1)S(F)(F)(F)(F)F)C(=O)Nc1cc(c(C)cc1C)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C29H27F5N6O2S/c1-18-9-19(2)27(39-7-8-40-28(39)14-26(37-40)20-5-4-6-35-15-20)13-25(18)36-29(41)21-10-22(38-16-23(17-38)42-3)12-24(11-21)43(30,31,32,33)34/h4-15,23H,16-17H2,1-3H3,(H,36,41)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239656
PNG
(US9394309, 112)
Show SMILES COCc1cc(cc(c1)S(F)(F)(F)(F)F)C(=O)Nc1cc(c(C)cc1C)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C27H24F5N5O2S/c1-17-9-18(2)25(36-7-8-37-26(36)14-24(35-37)20-5-4-6-33-15-20)13-23(17)34-27(38)21-10-19(16-39-3)11-22(12-21)40(28,29,30,31)32/h4-15H,16H2,1-3H3,(H,34,38)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239698
PNG
(US9394309, 155)
Show SMILES COCCOCc1cc(cc(c1)S(F)(F)(F)(F)F)C(=O)Nc1cc(c(C)cc1C)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C29H28F5N5O3S/c1-19-11-20(2)27(38-7-8-39-28(38)16-26(37-39)22-5-4-6-35-17-22)15-25(19)36-29(40)23-12-21(18-42-10-9-41-3)13-24(14-23)43(30,31,32,33)34/h4-8,11-17H,9-10,18H2,1-3H3,(H,36,40)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239559
PNG
(US9394309, 12)
Show SMILES Cc1cn(-c2cc(NC(=O)c3cc(cc(c3)S(F)(F)(F)(F)F)C#N)ccc2C)c2cc(nn12)-c1cn[nH]c1
Show InChI InChI=1S/C24H18F5N7OS/c1-14-3-4-19(33-24(37)17-5-16(10-30)6-20(7-17)38(25,26,27,28)29)8-22(14)35-13-15(2)36-23(35)9-21(34-36)18-11-31-32-12-18/h3-9,11-13H,1-2H3,(H,31,32)(H,33,37)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239563
PNG
(US9394309, 16)
Show SMILES Cc1nccn1-c1cc(cc(c1)S(F)(F)(F)(F)F)C(=O)Nc1ccc(C)c(c1)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C28H22F5N7OS/c1-18-5-6-22(14-26(18)39-10-11-40-27(39)16-25(37-40)20-4-3-7-34-17-20)36-28(41)21-12-23(38-9-8-35-19(38)2)15-24(13-21)42(29,30,31,32)33/h3-17H,1-2H3,(H,36,41)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239655
PNG
(US9394309, 111)
Show SMILES Cc1cc(cc(c1)S(F)(F)(F)(F)F)C(=O)Nc1cc(c(C)cc1C)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C26H22F5N5OS/c1-16-9-20(12-21(10-16)38(27,28,29,30)31)26(37)33-22-13-24(18(3)11-17(22)2)35-7-8-36-25(35)14-23(34-36)19-5-4-6-32-15-19/h4-15H,1-3H3,(H,33,37)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239598
PNG
(US9394309, 51)
Show SMILES Cc1ccc(NC(=O)c2cc(CN3CCCC3)cc(c2)C(C)(C)C)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C33H36N6O/c1-23-9-10-28(19-30(23)38-14-15-39-31(38)20-29(36-39)25-8-7-11-34-21-25)35-32(40)26-16-24(22-37-12-5-6-13-37)17-27(18-26)33(2,3)4/h7-11,14-21H,5-6,12-13,22H2,1-4H3,(H,35,40)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239565
PNG
(US9394309, 18)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)S(F)(F)(F)(F)F)C(=O)Nc1ccc(C)c(c1)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C29H28F5N7OS/c1-20-5-6-23(16-27(20)40-12-13-41-28(40)18-26(37-41)21-4-3-7-35-19-21)36-29(42)22-14-24(39-10-8-38(2)9-11-39)17-25(15-22)43(30,31,32,33)34/h3-7,12-19H,8-11H2,1-2H3,(H,36,42)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239652
PNG
(US9394309, 108)
Show SMILES Cc1cc(C)c(cc1NC(=O)c1cc(Cl)cc(c1)S(F)(F)(F)(F)F)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C25H19ClF5N5OS/c1-15-8-16(2)23(35-6-7-36-24(35)13-22(34-36)17-4-3-5-32-14-17)12-21(15)33-25(37)18-9-19(26)11-20(10-18)38(27,28,29,30)31/h3-14H,1-2H3,(H,33,37)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239719
PNG
(US9394309, 178)
Show SMILES Cc1ccc(NC(=O)c2cc(cc(c2)S(F)(F)(F)(F)F)C(C)(C)O)cc1-n1ccn2nc(cc12)-c1cncs1
Show InChI InChI=1S/C25H22F5N5O2S2/c1-15-4-5-18(11-21(15)34-6-7-35-23(34)12-20(33-35)22-13-31-14-38-22)32-24(36)16-8-17(25(2,3)37)10-19(9-16)39(26,27,28,29)30/h4-14,37H,1-3H3,(H,32,36)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239659
PNG
(US9394309, 115)
Show SMILES Cc1cc(C)c(cc1NC(=O)c1cc(Cl)nc(c1)C(C)(C)C)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C28H27ClN6O/c1-17-11-18(2)23(34-9-10-35-26(34)15-22(33-35)19-7-6-8-30-16-19)14-21(17)31-27(36)20-12-24(28(3,4)5)32-25(29)13-20/h6-16H,1-5H3,(H,31,36)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239573
PNG
(US9394309, 26)
Show SMILES Cc1ccc(NC(=O)c2cc(cc(c2)S(F)(F)(F)(F)F)S(C)(=O)=O)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C25H20F5N5O3S2/c1-16-5-6-19(12-23(16)34-8-9-35-24(34)14-22(33-35)17-4-3-7-31-15-17)32-25(36)18-10-20(39(2,37)38)13-21(11-18)40(26,27,28,29)30/h3-15H,1-2H3,(H,32,36)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239571
PNG
(US9394309, 24)
Show SMILES Cc1ccc(NC(=O)c2cc(OC3CNC3)cc(c2)S(F)(F)(F)(F)F)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C27H23F5N6O2S/c1-17-4-5-20(11-25(17)37-7-8-38-26(37)13-24(36-38)18-3-2-6-33-14-18)35-27(39)19-9-21(40-22-15-34-16-22)12-23(10-19)41(28,29,30,31)32/h2-14,22,34H,15-16H2,1H3,(H,35,39)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239717
PNG
(US9394309, 176)
Show SMILES Cc1ccc(NC(=O)c2cc(cc(c2)S(F)(F)(F)(F)F)S(C)(=O)=O)cc1-n1ccn2nc(cc12)-c1cncs1
Show InChI InChI=1S/C23H18F5N5O3S3/c1-14-3-4-16(9-20(14)32-5-6-33-22(32)11-19(31-33)21-12-29-13-37-21)30-23(34)15-7-17(38(2,35)36)10-18(8-15)39(24,25,26,27)28/h3-13H,1-2H3,(H,30,34)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239620
PNG
(US9394309, 73)
Show SMILES Cc1cc(C)c(cc1NC(=O)c1cccc(c1)S(F)(F)(F)(F)F)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C25H20F5N5OS/c1-16-11-17(2)23(34-9-10-35-24(34)14-22(33-35)19-6-4-8-31-15-19)13-21(16)32-25(36)18-5-3-7-20(12-18)37(26,27,28,29)30/h3-15H,1-2H3,(H,32,36)
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For measuring the autophosphorylation of the endogenous Tie2 receptor in the cell lysates prepared, a self-prepared anti-Tie2 antibody directed again...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239688
PNG
(US9394309, 145)
Show SMILES COC1CCN(CC1)c1cc(cc(c1)S(F)(F)(F)(F)F)C(=O)Nc1cc(c(C)cc1C)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C31H31F5N6O2S/c1-20-13-21(2)29(41-11-12-42-30(41)18-28(39-42)22-5-4-8-37-19-22)17-27(20)38-31(43)23-14-24(40-9-6-25(44-3)7-10-40)16-26(15-23)45(32,33,34,35)36/h4-5,8,11-19,25H,6-7,9-10H2,1-3H3,(H,38,43)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239685
PNG
(US9394309, 142)
Show SMILES Cc1cc(C)c(cc1NC(=O)c1cccc(c1)C(C)(C)F)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C28H26FN5O/c1-18-13-19(2)25(15-23(18)31-27(35)20-7-5-9-22(14-20)28(3,4)29)33-11-12-34-26(33)16-24(32-34)21-8-6-10-30-17-21/h5-17H,1-4H3,(H,31,35)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239566
PNG
(US9394309, 19)
Show SMILES Cc1ccc(NC(=O)c2cc(cc(c2)S(F)(F)(F)(F)F)N2CCOCC2)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C28H25F5N6O2S/c1-19-4-5-22(15-26(19)38-7-8-39-27(38)17-25(36-39)20-3-2-6-34-18-20)35-28(40)21-13-23(37-9-11-41-12-10-37)16-24(14-21)42(29,30,31,32)33/h2-8,13-18H,9-12H2,1H3,(H,35,40)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239651
PNG
(US9394309, 107)
Show SMILES Cc1cc(C)c(cc1NC(=O)c1cc(F)cc(c1)S(F)(F)(F)(F)F)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C25H19F6N5OS/c1-15-8-16(2)23(35-6-7-36-24(35)13-22(34-36)17-4-3-5-32-14-17)12-21(15)33-25(37)18-9-19(26)11-20(10-18)38(27,28,29,30)31/h3-14H,1-2H3,(H,33,37)
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Assay Description
For measuring the autophosphorylation of the endogenous Tie2 receptor in the cell lysates prepared, a self-prepared anti-Tie2 antibody directed again...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239710
PNG
(US9394309, 169)
Show SMILES Cc1cc(C)c(cc1NC(=O)c1cccc(c1)S(F)(F)(F)(F)F)-n1ccn2nc(cc12)-c1cccnn1
Show InChI InChI=1S/C24H19F5N6OS/c1-15-11-16(2)22(34-9-10-35-23(34)14-21(33-35)19-7-4-8-30-32-19)13-20(15)31-24(36)17-5-3-6-18(12-17)37(25,26,27,28)29/h3-14H,1-2H3,(H,31,36)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239700
PNG
(US9394309, 157)
Show SMILES Cc1cc(Cl)c(cc1NC(=O)c1cccc(c1)S(F)(F)(F)(F)F)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C24H17ClF5N5OS/c1-15-10-19(25)22(34-8-9-35-23(34)13-21(33-35)17-5-3-7-31-14-17)12-20(15)32-24(36)16-4-2-6-18(11-16)37(26,27,28,29)30/h2-14H,1H3,(H,32,36)
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Assay Description
For measuring the autophosphorylation of the endogenous Tie2 receptor in the cell lysates prepared, a self-prepared anti-Tie2 antibody directed again...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239703
PNG
(US9394309, 160)
Show SMILES Cc1ccc(NC(=O)c2cc(cc(c2)S(F)(F)(F)(F)F)C(C)(C)O)cc1-n1ccn2nc(c(F)c12)-c1cccnc1
Show InChI InChI=1S/C27H23F6N5O2S/c1-16-6-7-20(35-25(39)18-11-19(27(2,3)40)13-21(12-18)41(29,30,31,32)33)14-22(16)37-9-10-38-26(37)23(28)24(36-38)17-5-4-8-34-15-17/h4-15,40H,1-3H3,(H,35,39)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239578
PNG
(US9394309, 31)
Show SMILES Cc1ccc(NC(=O)c2cc(CO)cc(c2)S(F)(F)(F)(F)F)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C25H20F5N5O2S/c1-16-4-5-20(32-25(37)19-9-17(15-36)10-21(11-19)38(26,27,28,29)30)12-23(16)34-7-8-35-24(34)13-22(33-35)18-3-2-6-31-14-18/h2-14,36H,15H2,1H3,(H,32,37)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239633
PNG
(US9394309, 86)
Show SMILES Cc1cc(C)c(cc1NC(=O)c1cc(cc(c1)S(F)(F)(F)(F)F)C#N)-n1ccn2nc(cc12)-c1cn[nH]c1
Show InChI InChI=1S/C24H18F5N7OS/c1-14-5-15(2)22(35-3-4-36-23(35)10-21(34-36)18-12-31-32-13-18)9-20(14)33-24(37)17-6-16(11-30)7-19(8-17)38(25,26,27,28)29/h3-10,12-13H,1-2H3,(H,31,32)(H,33,37)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239550
PNG
(US9394309, 3)
Show SMILES Cc1ccc(NC(=O)c2cc(cc(c2)S(F)(F)(F)(F)F)N2CCOCC2)cc1-n1ccn2nc(cc12)-c1cn[nH]c1
Show InChI InChI=1S/C26H24F5N7O2S/c1-17-2-3-20(12-24(17)37-4-5-38-25(37)14-23(35-38)19-15-32-33-16-19)34-26(39)18-10-21(36-6-8-40-9-7-36)13-22(11-18)41(27,28,29,30)31/h2-5,10-16H,6-9H2,1H3,(H,32,33)(H,34,39)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239669
PNG
(US9394309, 126)
Show SMILES Cc1cc(C)c(cc1NC(=O)c1cccc(SC(F)(F)F)c1)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C26H20F3N5OS/c1-16-11-17(2)23(33-9-10-34-24(33)14-22(32-34)19-6-4-8-30-15-19)13-21(16)31-25(35)18-5-3-7-20(12-18)36-26(27,28)29/h3-15H,1-2H3,(H,31,35)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239711
PNG
(US9394309, 170)
Show SMILES Cc1cc(C)c(cc1NC(=O)c1cc(Br)cc(c1)S(F)(F)(F)(F)F)-n1ccn2nc(cc12)-c1cccnn1
Show InChI InChI=1S/C24H18BrF5N6OS/c1-14-8-15(2)22(35-6-7-36-23(35)13-21(34-36)19-4-3-5-31-33-19)12-20(14)32-24(37)16-9-17(25)11-18(10-16)38(26,27,28,29)30/h3-13H,1-2H3,(H,32,37)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239597
PNG
(US9394309, 50 | US9394309, 93)
Show SMILES Cc1ccc(NC(=O)c2cc(cc(c2)C(C)(C)C)C#N)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C29H26N6O/c1-19-7-8-24(32-28(36)22-12-20(17-30)13-23(14-22)29(2,3)4)15-26(19)34-10-11-35-27(34)16-25(33-35)21-6-5-9-31-18-21/h5-16,18H,1-4H3,(H,32,36)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239560
PNG
(US9394309, 13)
Show SMILES COc1cc(cc(c1)S(F)(F)(F)(F)F)C(=O)Nc1ccc(C)c(c1)-n1cc(C)n2nc(cc12)-c1cn[nH]c1
Show InChI InChI=1S/C24H21F5N6O2S/c1-14-4-5-18(32-24(36)16-6-19(37-3)9-20(7-16)38(25,26,27,28)29)8-22(14)34-13-15(2)35-23(34)10-21(33-35)17-11-30-31-12-17/h4-13H,1-3H3,(H,30,31)(H,32,36)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239686
PNG
(US9394309, 143)
Show SMILES Cc1cc(C)c(cc1NC(=O)c1cc(cc(c1)S(F)(F)(F)(F)F)N1CCCCC1)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C30H29F5N6OS/c1-20-13-21(2)28(40-11-12-41-29(40)18-27(38-41)22-7-6-8-36-19-22)17-26(20)37-30(42)23-14-24(39-9-4-3-5-10-39)16-25(15-23)43(31,32,33,34)35/h6-8,11-19H,3-5,9-10H2,1-2H3,(H,37,42)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239656
PNG
(US9394309, 112)
Show SMILES COCc1cc(cc(c1)S(F)(F)(F)(F)F)C(=O)Nc1cc(c(C)cc1C)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C27H24F5N5O2S/c1-17-9-18(2)25(36-7-8-37-26(36)14-24(35-37)20-5-4-6-33-15-20)13-23(17)34-27(38)21-10-19(16-39-3)11-22(12-21)40(28,29,30,31)32/h4-15H,16H2,1-3H3,(H,34,38)
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Assay Description
For measuring the autophosphorylation of the endogenous Tie2 receptor in the cell lysates prepared, a self-prepared anti-Tie2 antibody directed again...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239670
PNG
(US9394309, 127)
Show SMILES Cc1cc(C)c(cc1NC(=O)c1cccc(OC(F)(F)F)c1)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C26H20F3N5O2/c1-16-11-17(2)23(33-9-10-34-24(33)14-22(32-34)19-6-4-8-30-15-19)13-21(16)31-25(35)18-5-3-7-20(12-18)36-26(27,28)29/h3-15H,1-2H3,(H,31,35)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239589
PNG
(US9394309, 42)
Show SMILES CN(C)CCCN(C)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1ccc(C)c(c1)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C31H32F3N7O/c1-21-8-9-25(18-28(21)40-13-14-41-29(40)19-27(37-41)22-7-5-10-35-20-22)36-30(42)23-15-24(31(32,33)34)17-26(16-23)39(4)12-6-11-38(2)3/h5,7-10,13-20H,6,11-12H2,1-4H3,(H,36,42)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239622
PNG
(US9394309, 75)
Show SMILES Cc1cc(F)c(NC(=O)c2cc(cc(c2)S(F)(F)(F)(F)F)C#N)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C25H16F6N6OS/c1-15-7-20(26)22(34-25(38)18-8-16(13-32)9-19(10-18)39(27,28,29,30)31)11-23(15)36-5-6-37-24(36)12-21(35-37)17-3-2-4-33-14-17/h2-12,14H,1H3,(H,34,38)
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Assay Description
For measuring the autophosphorylation of the endogenous Tie2 receptor in the cell lysates prepared, a self-prepared anti-Tie2 antibody directed again...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239707
PNG
(US9394309, 165)
Show SMILES Cc1cc(C)c(cc1NC(=O)c1cc(Br)cc(c1)S(F)(F)(F)(F)F)-n1ccn2nc(cc12)-c1cncnc1
Show InChI InChI=1S/C24H18BrF5N6OS/c1-14-5-15(2)22(35-3-4-36-23(35)10-21(34-36)17-11-31-13-32-12-17)9-20(14)33-24(37)16-6-18(25)8-19(7-16)38(26,27,28,29)30/h3-13H,1-2H3,(H,33,37)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239718
PNG
(US9394309, 177)
Show SMILES Cc1ccc(NC(=O)c2cc(cc(c2)S(F)(F)(F)(F)F)C#N)cc1-n1ccn2nc(cc12)-c1cncs1
Show InChI InChI=1S/C23H15F5N6OS2/c1-14-2-3-17(31-23(35)16-6-15(11-29)7-18(8-16)37(24,25,26,27)28)9-20(14)33-4-5-34-22(33)10-19(32-34)21-12-30-13-36-21/h2-10,12-13H,1H3,(H,31,35)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239555
PNG
(US9394309, 8)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(C)(C)C)C(=O)Nc1ccc(C)c(c1)-n1ccn2nc(cc12)-c1cn[nH]c1
Show InChI InChI=1S/C31H36N8O/c1-21-6-7-25(17-28(21)38-12-13-39-29(38)18-27(35-39)23-19-32-33-20-23)34-30(40)22-14-24(31(2,3)4)16-26(15-22)37-10-8-36(5)9-11-37/h6-7,12-20H,8-11H2,1-5H3,(H,32,33)(H,34,40)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239572
PNG
(US9394309, 25)
Show SMILES Cc1ccc(NC(=O)c2cc(OC3CCNC3)cc(c2)S(F)(F)(F)(F)F)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C28H25F5N6O2S/c1-18-4-5-21(13-26(18)38-9-10-39-27(38)15-25(37-39)19-3-2-7-34-16-19)36-28(40)20-11-23(41-22-6-8-35-17-22)14-24(12-20)42(29,30,31,32)33/h2-5,7,9-16,22,35H,6,8,17H2,1H3,(H,36,40)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239577
PNG
(US9394309, 30)
Show SMILES Cc1cc(cc(c1)S(F)(F)(F)(F)F)C(=O)Nc1ccc(C)c(c1)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C25H20F5N5OS/c1-16-10-19(12-21(11-16)37(26,27,28,29)30)25(36)32-20-6-5-17(2)23(13-20)34-8-9-35-24(34)14-22(33-35)18-4-3-7-31-15-18/h3-15H,1-2H3,(H,32,36)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239576
PNG
(US9394309, 29)
Show SMILES Cc1ccc(NC(=O)c2cc(cc(c2)S(F)(F)(F)(F)F)C(N)=O)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C25H19F5N6O2S/c1-15-4-5-19(33-25(38)18-9-17(24(31)37)10-20(11-18)39(26,27,28,29)30)12-22(15)35-7-8-36-23(35)13-21(34-36)16-3-2-6-32-14-16/h2-14H,1H3,(H2,31,37)(H,33,38)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239579
PNG
(US9394309, 32)
Show SMILES Cc1ccc(NC(=O)c2cc(cc(c2)S(F)(F)(F)(F)F)C(C)(C)O)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C27H24F5N5O2S/c1-17-6-7-21(14-24(17)36-9-10-37-25(36)15-23(35-37)18-5-4-8-33-16-18)34-26(38)19-11-20(27(2,3)39)13-22(12-19)40(28,29,30,31)32/h4-16,39H,1-3H3,(H,34,38)
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Assay Description
For measuring the autophosphorylation of the endogenous Tie2 receptor in the cell lysates prepared, a self-prepared anti-Tie2 antibody directed again...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239568
PNG
(US9394309, 21)
Show SMILES COc1cc(cc(c1)S(F)(F)(F)(F)F)C(=O)Nc1ccc(C)c(c1)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C25H20F5N5O2S/c1-16-5-6-19(32-25(36)18-10-20(37-2)13-21(11-18)38(26,27,28,29)30)12-23(16)34-8-9-35-24(34)14-22(33-35)17-4-3-7-31-15-17/h3-15H,1-2H3,(H,32,36)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239581
PNG
(US9394309, 34)
Show SMILES Cc1ccc(NC(=O)c2cc(CN3CC[C@H](O)C3)cc(c2)S(F)(F)(F)(F)F)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C29H27F5N6O2S/c1-19-4-5-23(14-27(19)39-9-10-40-28(39)15-26(37-40)21-3-2-7-35-16-21)36-29(42)22-11-20(17-38-8-6-24(41)18-38)12-25(13-22)43(30,31,32,33)34/h2-5,7,9-16,24,41H,6,8,17-18H2,1H3,(H,36,42)/t24-/m0/s1
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239575
PNG
(US9394309, 28)
Show SMILES Cc1ccc(NC(=O)c2cc(cc(c2)S(F)(F)(F)(F)F)C#N)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C25H17F5N6OS/c1-16-4-5-20(33-25(37)19-9-17(14-31)10-21(11-19)38(26,27,28,29)30)12-23(16)35-7-8-36-24(35)13-22(34-36)18-3-2-6-32-15-18/h2-13,15H,1H3,(H,33,37)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239587
PNG
(US9394309, 40)
Show SMILES Cc1nccn1-c1cc(cc(c1)C(F)(F)F)C(=O)Nc1ccc(C)c(c1)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C29H22F3N7O/c1-18-5-6-23(15-26(18)38-10-11-39-27(38)16-25(36-39)20-4-3-7-33-17-20)35-28(40)21-12-22(29(30,31)32)14-24(13-21)37-9-8-34-19(37)2/h3-17H,1-2H3,(H,35,40)
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Assay Description
For measuring the autophosphorylation of the endogenous Tie2 receptor in the cell lysates prepared, a self-prepared anti-Tie2 antibody directed again...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239692
PNG
(US9394309, 149)
Show SMILES Cc1cc(C)c(cc1NC(=O)c1cc(cc(c1)S(F)(F)(F)(F)F)C(C)(C)F)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C28H25F6N5OS/c1-17-10-18(2)25(38-8-9-39-26(38)15-24(37-39)19-6-5-7-35-16-19)14-23(17)36-27(40)20-11-21(28(3,4)29)13-22(12-20)41(30,31,32,33)34/h5-16H,1-4H3,(H,36,40)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239636
PNG
(US9394309, 89)
Show SMILES Cc1ccc(NC(=O)c2cc(Br)cc(c2)S(F)(F)(F)(F)F)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C24H17BrF5N5OS/c1-15-4-5-19(32-24(36)17-9-18(25)11-20(10-17)37(26,27,28,29)30)12-22(15)34-7-8-35-23(34)13-21(33-35)16-3-2-6-31-14-16/h2-14H,1H3,(H,32,36)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239693
PNG
(US9394309, 150)
Show SMILES Cc1cc(C)c(cc1NC(=O)c1cc(CC(=O)OC(C)(C)C)cc(c1)S(F)(F)(F)(F)F)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C31H30F5N5O3S/c1-19-11-20(2)27(40-9-10-41-28(40)17-26(39-41)22-7-6-8-37-18-22)16-25(19)38-30(43)23-12-21(14-29(42)44-31(3,4)5)13-24(15-23)45(32,33,34,35)36/h6-13,15-18H,14H2,1-5H3,(H,38,43)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239580
PNG
(US9394309, 33)
Show SMILES Cc1ccc(NC(=O)c2cc(CN3CCCC3)cc(c2)S(F)(F)(F)(F)F)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C29H27F5N6OS/c1-20-6-7-24(16-27(20)39-11-12-40-28(39)17-26(37-40)22-5-4-8-35-18-22)36-29(41)23-13-21(19-38-9-2-3-10-38)14-25(15-23)42(30,31,32,33)34/h4-8,11-18H,2-3,9-10,19H2,1H3,(H,36,41)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239715
PNG
(US9394309, 174)
Show SMILES Cc1ccc(NC(=O)c2cc(Cl)cc(c2)S(F)(F)(F)(F)F)cc1-n1ccn2nc(cc12)-c1cncs1
Show InChI InChI=1S/C22H15ClF5N5OS2/c1-13-2-3-16(30-22(34)14-6-15(23)8-17(7-14)36(24,25,26,27)28)9-19(13)32-4-5-33-21(32)10-18(31-33)20-11-29-12-35-20/h2-12H,1H3,(H,30,34)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239660
PNG
(US9394309, 116)
Show SMILES Cc1cc(C)c(cc1NC(=O)c1cc(nc(c1)C(C)(C)C)C#N)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C29H27N7O/c1-18-11-19(2)25(35-9-10-36-27(35)15-24(34-36)20-7-6-8-31-17-20)14-23(18)33-28(37)21-12-22(16-30)32-26(13-21)29(3,4)5/h6-15,17H,1-5H3,(H,33,37)
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For measuring the autophosphorylation of the endogenous Tie2 receptor in the cell lysates prepared, a self-prepared anti-Tie2 antibody directed again...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239573
PNG
(US9394309, 26)
Show SMILES Cc1ccc(NC(=O)c2cc(cc(c2)S(F)(F)(F)(F)F)S(C)(=O)=O)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C25H20F5N5O3S2/c1-16-5-6-19(12-23(16)34-8-9-35-24(34)14-22(33-35)17-4-3-7-31-15-17)32-25(36)18-10-20(39(2,37)38)13-21(11-18)40(26,27,28,29)30/h3-15H,1-2H3,(H,32,36)
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For measuring the autophosphorylation of the endogenous Tie2 receptor in the cell lysates prepared, a self-prepared anti-Tie2 antibody directed again...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239567
PNG
(US9394309, 20)
Show SMILES Cc1ccc(NC(=O)c2cc(O)cc(c2)S(F)(F)(F)(F)F)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C24H18F5N5O2S/c1-15-4-5-18(31-24(36)17-9-19(35)12-20(10-17)37(25,26,27,28)29)11-22(15)33-7-8-34-23(33)13-21(32-34)16-3-2-6-30-14-16/h2-14,35H,1H3,(H,31,36)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239574
PNG
(US9394309, 27)
Show SMILES Cc1ccc(NC(=O)c2cc(Cl)cc(c2)S(F)(F)(F)(F)F)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C24H17ClF5N5OS/c1-15-4-5-19(32-24(36)17-9-18(25)11-20(10-17)37(26,27,28,29)30)12-22(15)34-7-8-35-23(34)13-21(33-35)16-3-2-6-31-14-16/h2-14H,1H3,(H,32,36)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239563
PNG
(US9394309, 16)
Show SMILES Cc1nccn1-c1cc(cc(c1)S(F)(F)(F)(F)F)C(=O)Nc1ccc(C)c(c1)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C28H22F5N7OS/c1-18-5-6-22(14-26(18)39-10-11-40-27(39)16-25(37-40)20-4-3-7-34-17-20)36-28(41)21-12-23(38-9-8-35-19(38)2)15-24(13-21)42(29,30,31,32)33/h3-17H,1-2H3,(H,36,41)
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For measuring the autophosphorylation of the endogenous Tie2 receptor in the cell lysates prepared, a self-prepared anti-Tie2 antibody directed again...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239716
PNG
(US9394309, 175)
Show SMILES Cc1ccc(NC(=O)c2cc(Br)cc(c2)S(F)(F)(F)(F)F)cc1-n1ccn2nc(cc12)-c1cncs1
Show InChI InChI=1S/C22H15BrF5N5OS2/c1-13-2-3-16(30-22(34)14-6-15(23)8-17(7-14)36(24,25,26,27)28)9-19(13)32-4-5-33-21(32)10-18(31-33)20-11-29-12-35-20/h2-12H,1H3,(H,30,34)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239672
PNG
(US9394309, 129)
Show SMILES Cc1cc(C)c(cc1NC(=O)c1cccc(OC(F)(F)C(F)F)c1)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C27H21F4N5O2/c1-16-11-17(2)23(35-9-10-36-24(35)14-22(34-36)19-6-4-8-32-15-19)13-21(16)33-25(37)18-5-3-7-20(12-18)38-27(30,31)26(28)29/h3-15,26H,1-2H3,(H,33,37)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239550
PNG
(US9394309, 3)
Show SMILES Cc1ccc(NC(=O)c2cc(cc(c2)S(F)(F)(F)(F)F)N2CCOCC2)cc1-n1ccn2nc(cc12)-c1cn[nH]c1
Show InChI InChI=1S/C26H24F5N7O2S/c1-17-2-3-20(12-24(17)37-4-5-38-25(37)14-23(35-38)19-15-32-33-16-19)34-26(39)18-10-21(36-6-8-40-9-7-36)13-22(11-18)41(27,28,29,30)31/h2-5,10-16H,6-9H2,1H3,(H,32,33)(H,34,39)
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Assay Description
For measuring the autophosphorylation of the endogenous Tie2 receptor in the cell lysates prepared, a self-prepared anti-Tie2 antibody directed again...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239575
PNG
(US9394309, 28)
Show SMILES Cc1ccc(NC(=O)c2cc(cc(c2)S(F)(F)(F)(F)F)C#N)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C25H17F5N6OS/c1-16-4-5-20(33-25(37)19-9-17(14-31)10-21(11-19)38(26,27,28,29)30)12-23(16)35-7-8-36-24(35)13-22(34-36)18-3-2-6-32-15-18/h2-13,15H,1H3,(H,33,37)
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Assay Description
For measuring the autophosphorylation of the endogenous Tie2 receptor in the cell lysates prepared, a self-prepared anti-Tie2 antibody directed again...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239665
PNG
(US9394309, 122)
Show SMILES Cc1ccc(NC(=O)c2cc(cc(c2)S(N)(=O)=O)C(F)(F)F)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C25H19F3N6O3S/c1-15-4-5-19(31-24(35)17-9-18(25(26,27)28)11-20(10-17)38(29,36)37)12-22(15)33-7-8-34-23(33)13-21(32-34)16-3-2-6-30-14-16/h2-14H,1H3,(H,31,35)(H2,29,36,37)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239675
PNG
(US9394309, 132)
Show SMILES CC(C)Oc1cccc(c1)C(=O)Nc1cc(c(C)cc1C)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C28H27N5O2/c1-18(2)35-23-9-5-7-21(14-23)28(34)30-24-15-26(20(4)13-19(24)3)32-11-12-33-27(32)16-25(31-33)22-8-6-10-29-17-22/h5-18H,1-4H3,(H,30,34)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239551
PNG
(US9394309, 4)
Show SMILES Cc1ccc(NC(=O)c2cc(cc(c2)S(F)(F)(F)(F)F)C(C)(C)O)cc1-n1ccn2nc(cc12)-c1cn[nH]c1
Show InChI InChI=1S/C25H23F5N6O2S/c1-15-4-5-19(11-22(15)35-6-7-36-23(35)12-21(34-36)17-13-31-32-14-17)33-24(37)16-8-18(25(2,3)38)10-20(9-16)39(26,27,28,29)30/h4-14,38H,1-3H3,(H,31,32)(H,33,37)
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Assay Description
For measuring the autophosphorylation of the endogenous Tie2 receptor in the cell lysates prepared, a self-prepared anti-Tie2 antibody directed again...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239559
PNG
(US9394309, 12)
Show SMILES Cc1cn(-c2cc(NC(=O)c3cc(cc(c3)S(F)(F)(F)(F)F)C#N)ccc2C)c2cc(nn12)-c1cn[nH]c1
Show InChI InChI=1S/C24H18F5N7OS/c1-14-3-4-19(33-24(37)17-5-16(10-30)6-20(7-17)38(25,26,27,28)29)8-22(14)35-13-15(2)36-23(35)9-21(34-36)18-11-31-32-12-18/h3-9,11-13H,1-2H3,(H,31,32)(H,33,37)
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Assay Description
For measuring the autophosphorylation of the endogenous Tie2 receptor in the cell lysates prepared, a self-prepared anti-Tie2 antibody directed again...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239654
PNG
(US9394309, 110)
Show SMILES Cc1cc(C)c(cc1NC(=O)c1cc(cc(c1)S(F)(F)(F)(F)F)C(O)=O)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C26H20F5N5O3S/c1-15-8-16(2)23(35-6-7-36-24(35)13-22(34-36)17-4-3-5-32-14-17)12-21(15)33-25(37)18-9-19(26(38)39)11-20(10-18)40(27,28,29,30)31/h3-14H,1-2H3,(H,33,37)(H,38,39)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239553
PNG
(US9394309, 6)
Show SMILES Cc1nccn1-c1cc(cc(c1)C(F)(F)F)C(=O)Nc1ccc(C)c(c1)-n1ccn2nc(cc12)-c1cn[nH]c1
Show InChI InChI=1S/C27H21F3N8O/c1-16-3-4-21(12-24(16)37-7-8-38-25(37)13-23(35-38)19-14-32-33-15-19)34-26(39)18-9-20(27(28,29)30)11-22(10-18)36-6-5-31-17(36)2/h3-15H,1-2H3,(H,32,33)(H,34,39)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239699
PNG
(US9394309, 156)
Show SMILES Cc1ccc(NC(=O)c2cc(cc(c2)S(F)(F)(F)(F)F)C#N)c(O)c1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C25H17F5N6O2S/c1-15-4-5-20(33-25(38)18-9-16(13-31)10-19(11-18)39(26,27,28,29)30)24(37)23(15)35-7-8-36-22(35)12-21(34-36)17-3-2-6-32-14-17/h2-12,14,37H,1H3,(H,33,38)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239549
PNG
(US9394309, 2)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)S(F)(F)(F)(F)F)C(=O)Nc1ccc(C)c(c1)-n1ccn2nc(cc12)-c1cn[nH]c1
Show InChI InChI=1S/C27H27F5N8OS/c1-18-3-4-21(13-25(18)39-9-10-40-26(39)15-24(36-40)20-16-33-34-17-20)35-27(41)19-11-22(38-7-5-37(2)6-8-38)14-23(12-19)42(28,29,30,31)32/h3-4,9-17H,5-8H2,1-2H3,(H,33,34)(H,35,41)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239694
PNG
(US9394309, 151)
Show SMILES Cc1cc(C)c(cc1NC(=O)c1cc(CC(O)=O)cc(c1)S(F)(F)(F)(F)F)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C27H22F5N5O3S/c1-16-8-17(2)24(36-6-7-37-25(36)14-23(35-37)19-4-3-5-33-15-19)13-22(16)34-27(40)20-9-18(11-26(38)39)10-21(12-20)41(28,29,30,31)32/h3-10,12-15H,11H2,1-2H3,(H,34,40)(H,38,39)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239595
PNG
(US9394309, 48)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(C)(C)C)C(=O)Nc1ccc(C)c(c1)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C33H37N7O/c1-23-8-9-27(20-30(23)39-15-16-40-31(39)21-29(36-40)24-7-6-10-34-22-24)35-32(41)25-17-26(33(2,3)4)19-28(18-25)38-13-11-37(5)12-14-38/h6-10,15-22H,11-14H2,1-5H3,(H,35,41)
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Assay Description
For measuring the autophosphorylation of the endogenous Tie2 receptor in the cell lysates prepared, a self-prepared anti-Tie2 antibody directed again...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239556
PNG
(US9394309, 9)
Show SMILES Cc1ccc(NC(=O)c2cc(CN3CCCC3)cc(c2)C(C)(C)C)cc1-n1ccn2nc(cc12)-c1cn[nH]c1
Show InChI InChI=1S/C31H35N7O/c1-21-7-8-26(16-28(21)37-11-12-38-29(37)17-27(35-38)24-18-32-33-19-24)34-30(39)23-13-22(20-36-9-5-6-10-36)14-25(15-23)31(2,3)4/h7-8,11-19H,5-6,9-10,20H2,1-4H3,(H,32,33)(H,34,39)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239549
PNG
(US9394309, 2)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)S(F)(F)(F)(F)F)C(=O)Nc1ccc(C)c(c1)-n1ccn2nc(cc12)-c1cn[nH]c1
Show InChI InChI=1S/C27H27F5N8OS/c1-18-3-4-21(13-25(18)39-9-10-40-26(39)15-24(36-40)20-16-33-34-17-20)35-27(41)19-11-22(38-7-5-37(2)6-8-38)14-23(12-19)42(28,29,30,31)32/h3-4,9-17H,5-8H2,1-2H3,(H,33,34)(H,35,41)
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Assay Description
For measuring the autophosphorylation of the endogenous Tie2 receptor in the cell lysates prepared, a self-prepared anti-Tie2 antibody directed again...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239713
PNG
(US9394309, 172)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)S(F)(F)(F)(F)F)cc1-n1ccn2nc(cc12)-c1cncs1
Show InChI InChI=1S/C22H16F5N5OS2/c1-14-5-6-16(29-22(33)15-3-2-4-17(9-15)35(23,24,25,26)27)10-19(14)31-7-8-32-21(31)11-18(30-32)20-12-28-13-34-20/h2-13H,1H3,(H,29,33)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239613
PNG
(US9394309, 66)
Show SMILES CNc1cc(cc(n1)C(C)(C)C)C(=O)Nc1ccc(C)c(c1)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C28H29N7O/c1-18-8-9-21(31-27(36)20-13-24(28(2,3)4)32-25(14-20)29-5)15-23(18)34-11-12-35-26(34)16-22(33-35)19-7-6-10-30-17-19/h6-17H,1-5H3,(H,29,32)(H,31,36)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239598
PNG
(US9394309, 51)
Show SMILES Cc1ccc(NC(=O)c2cc(CN3CCCC3)cc(c2)C(C)(C)C)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C33H36N6O/c1-23-9-10-28(19-30(23)38-14-15-39-31(38)20-29(36-39)25-8-7-11-34-21-25)35-32(40)26-16-24(22-37-12-5-6-13-37)17-27(18-26)33(2,3)4/h7-11,14-21H,5-6,12-13,22H2,1-4H3,(H,35,40)
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Assay Description
For measuring the autophosphorylation of the endogenous Tie2 receptor in the cell lysates prepared, a self-prepared anti-Tie2 antibody directed again...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239624
PNG
(US9394309, 77)
Show SMILES Cc1ccc(cc1NC(=O)c1cc(cc(c1)S(F)(F)(F)(F)F)C#N)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C25H17F5N6OS/c1-16-4-5-20(35-7-8-36-24(35)13-23(34-36)18-3-2-6-32-15-18)12-22(16)33-25(37)19-9-17(14-31)10-21(11-19)38(26,27,28,29)30/h2-13,15H,1H3,(H,33,37)
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Assay Description
For measuring the autophosphorylation of the endogenous Tie2 receptor in the cell lysates prepared, a self-prepared anti-Tie2 antibody directed again...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239705
PNG
(US9394309, 163)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)S(F)(F)(F)(F)F)cc1-n1ccn2nc(cc12)-c1cncnc1
Show InChI InChI=1S/C23H17F5N6OS/c1-15-5-6-18(31-23(35)16-3-2-4-19(9-16)36(24,25,26,27)28)10-21(15)33-7-8-34-22(33)11-20(32-34)17-12-29-14-30-13-17/h2-14H,1H3,(H,31,35)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239704
PNG
(US9394309, 162)
Show SMILES Cc1ccc(NC(=O)c2cc(cc(c2)S(F)(F)(F)(F)F)C#N)cc1-n1ccn2nc(cc12)-c1cnccn1
Show InChI InChI=1S/C24H16F5N7OS/c1-15-2-3-18(33-24(37)17-8-16(13-30)9-19(10-17)38(25,26,27,28)29)11-22(15)35-6-7-36-23(35)12-20(34-36)21-14-31-4-5-32-21/h2-12,14H,1H3,(H,33,37)
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Assay Description
For measuring the autophosphorylation of the endogenous Tie2 receptor in the cell lysates prepared, a self-prepared anti-Tie2 antibody directed again...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239643
PNG
(US9394309, 97)
Show SMILES FS(F)(F)(F)(F)c1cc(cc(c1)C(=O)Nc1ccc(Cl)c(c1)-n1ccn2nc(cc12)-c1cccnc1)C#N
Show InChI InChI=1S/C24H14ClF5N6OS/c25-20-4-3-18(33-24(37)17-8-15(13-31)9-19(10-17)38(26,27,28,29)30)11-22(20)35-6-7-36-23(35)12-21(34-36)16-2-1-5-32-14-16/h1-12,14H,(H,33,37)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239714
PNG
(US9394309, 173)
Show SMILES Cc1ccc(NC(=O)c2cc(F)cc(c2)S(F)(F)(F)(F)F)cc1-n1ccn2nc(cc12)-c1cncs1
Show InChI InChI=1S/C22H15F6N5OS2/c1-13-2-3-16(30-22(34)14-6-15(23)8-17(7-14)36(24,25,26,27)28)9-19(13)32-4-5-33-21(32)10-18(31-33)20-11-29-12-35-20/h2-12H,1H3,(H,30,34)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239702
PNG
(US9394309, 159)
Show SMILES Cc1ccc(NC(=O)c2cc(cc(c2)S(F)(F)(F)(F)F)C#N)cc1-n1ccn2nc(c(F)c12)-c1cccnc1
Show InChI InChI=1S/C25H16F6N6OS/c1-15-4-5-19(34-24(38)18-9-16(13-32)10-20(11-18)39(27,28,29,30)31)12-21(15)36-7-8-37-25(36)22(26)23(35-37)17-3-2-6-33-14-17/h2-12,14H,1H3,(H,34,38)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239565
PNG
(US9394309, 18)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)S(F)(F)(F)(F)F)C(=O)Nc1ccc(C)c(c1)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C29H28F5N7OS/c1-20-5-6-23(16-27(20)40-12-13-41-28(40)18-26(37-41)21-4-3-7-35-19-21)36-29(42)22-14-24(39-10-8-38(2)9-11-39)17-25(15-22)43(30,31,32,33)34/h3-7,12-19H,8-11H2,1-2H3,(H,36,42)
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Assay Description
For measuring the autophosphorylation of the endogenous Tie2 receptor in the cell lysates prepared, a self-prepared anti-Tie2 antibody directed again...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239624
PNG
(US9394309, 77)
Show SMILES Cc1ccc(cc1NC(=O)c1cc(cc(c1)S(F)(F)(F)(F)F)C#N)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C25H17F5N6OS/c1-16-4-5-20(35-7-8-36-24(35)13-23(34-36)18-3-2-6-32-15-18)12-22(16)33-25(37)19-9-17(14-31)10-21(11-19)38(26,27,28,29)30/h2-13,15H,1H3,(H,33,37)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239585
PNG
(US9394309, 38)
Show SMILES Cc1ccc(NC(=O)c2cc(OC(F)(F)F)cc(c2)C#N)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C26H17F3N6O2/c1-16-4-5-20(32-25(36)19-9-17(14-30)10-21(11-19)37-26(27,28)29)12-23(16)34-7-8-35-24(34)13-22(33-35)18-3-2-6-31-15-18/h2-13,15H,1H3,(H,32,36)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239553
PNG
(US9394309, 6)
Show SMILES Cc1nccn1-c1cc(cc(c1)C(F)(F)F)C(=O)Nc1ccc(C)c(c1)-n1ccn2nc(cc12)-c1cn[nH]c1
Show InChI InChI=1S/C27H21F3N8O/c1-16-3-4-21(12-24(16)37-7-8-38-25(37)13-23(35-38)19-14-32-33-15-19)34-26(39)18-9-20(27(28,29)30)11-22(10-18)36-6-5-31-17(36)2/h3-15H,1-2H3,(H,32,33)(H,34,39)
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Assay Description
For measuring the autophosphorylation of the endogenous Tie2 receptor in the cell lysates prepared, a self-prepared anti-Tie2 antibody directed again...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239664
PNG
(US9394309, 121)
Show SMILES Cc1ccc(NC(=O)c2cc(cc(c2)S(F)(F)(F)(F)F)C#N)c(C)c1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C26H19F5N6OS/c1-16-5-6-22(34-26(38)20-10-18(14-32)11-21(12-20)39(27,28,29,30)31)17(2)25(16)36-8-9-37-24(36)13-23(35-37)19-4-3-7-33-15-19/h3-13,15H,1-2H3,(H,34,38)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239647
PNG
(US9394309, 102)
Show SMILES Cc1cc(NC(=O)c2cc(cc(c2)S(F)(F)(F)(F)F)C#N)cc(c1C)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C26H19F5N6OS/c1-16-8-21(34-26(38)20-9-18(14-32)10-22(11-20)39(27,28,29,30)31)12-24(17(16)2)36-6-7-37-25(36)13-23(35-37)19-4-3-5-33-15-19/h3-13,15H,1-2H3,(H,34,38)
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Assay Description
For measuring the autophosphorylation of the endogenous Tie2 receptor in the cell lysates prepared, a self-prepared anti-Tie2 antibody directed again...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239647
PNG
(US9394309, 102)
Show SMILES Cc1cc(NC(=O)c2cc(cc(c2)S(F)(F)(F)(F)F)C#N)cc(c1C)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C26H19F5N6OS/c1-16-8-21(34-26(38)20-9-18(14-32)10-22(11-20)39(27,28,29,30)31)12-24(17(16)2)36-6-7-37-25(36)13-23(35-37)19-4-3-5-33-15-19/h3-13,15H,1-2H3,(H,34,38)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239597
PNG
(US9394309, 50 | US9394309, 93)
Show SMILES Cc1ccc(NC(=O)c2cc(cc(c2)C(C)(C)C)C#N)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C29H26N6O/c1-19-7-8-24(32-28(36)22-12-20(17-30)13-23(14-22)29(2,3)4)15-26(19)34-10-11-35-27(34)16-25(33-35)21-6-5-9-31-18-21/h5-16,18H,1-4H3,(H,32,36)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239632
PNG
(US9394309, 85)
Show SMILES Cc1ccc(NC(=O)c2cc(cc(c2)S(F)(F)(F)(F)F)C#N)cc1-n1ccn2nc(cc12)-c1cn[nH]c1
Show InChI InChI=1S/C23H16F5N7OS/c1-14-2-3-18(32-23(36)16-6-15(11-29)7-19(8-16)37(24,25,26,27)28)9-21(14)34-4-5-35-22(34)10-20(33-35)17-12-30-31-13-17/h2-10,12-13H,1H3,(H,30,31)(H,32,36)
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Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH

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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239635
PNG
(US9394309, 88)
Show SMILES Cc1ccc(NC(=O)c2cc(F)cc(c2)S(F)(F)(F)(F)F)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C24H17F6N5OS/c1-15-4-5-19(32-24(36)17-9-18(25)11-20(10-17)37(26,27,28,29)30)12-22(15)34-7-8-35-23(34)13-21(33-35)16-3-2-6-31-14-16/h2-14H,1H3,(H,32,36)
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Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH

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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239673
PNG
(US9394309, 130)
Show SMILES Cc1cc(C)c(cc1NC(=O)c1cccc(OCC(F)(F)F)c1)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C27H22F3N5O2/c1-17-11-18(2)24(34-9-10-35-25(34)14-23(33-35)20-6-4-8-31-15-20)13-22(17)32-26(36)19-5-3-7-21(12-19)37-16-27(28,29)30/h3-15H,16H2,1-2H3,(H,32,36)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239562
PNG
(US9394309, 15)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)S(F)(F)(F)(F)F)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C24H18F5N5OS/c1-16-7-8-19(31-24(35)17-4-2-6-20(12-17)36(25,26,27,28)29)13-22(16)33-10-11-34-23(33)14-21(32-34)18-5-3-9-30-15-18/h2-15H,1H3,(H,31,35)
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Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH

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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239626
PNG
(US9394309, 79)
Show SMILES Cc1ccc(cc1NC(=O)c1cc(cc(c1)C(C)(C)C)C#N)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C29H26N6O/c1-19-7-8-24(34-10-11-35-27(34)16-26(33-35)21-6-5-9-31-18-21)15-25(19)32-28(36)22-12-20(17-30)13-23(14-22)29(2,3)4/h5-16,18H,1-4H3,(H,32,36)
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Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH

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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239704
PNG
(US9394309, 162)
Show SMILES Cc1ccc(NC(=O)c2cc(cc(c2)S(F)(F)(F)(F)F)C#N)cc1-n1ccn2nc(cc12)-c1cnccn1
Show InChI InChI=1S/C24H16F5N7OS/c1-15-2-3-18(33-24(37)17-8-16(13-30)9-19(10-17)38(25,26,27,28)29)11-22(15)35-6-7-36-23(35)12-20(34-36)21-14-31-4-5-32-21/h2-12,14H,1H3,(H,33,37)
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Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH

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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239639
PNG
(US9394309, 92)
Show SMILES Cc1ccc(NC(=O)c2cc(cc(c2)C2(O)CCC2)C#N)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C29H24N6O2/c1-19-5-6-24(32-28(36)22-12-20(17-30)13-23(14-22)29(37)7-3-8-29)15-26(19)34-10-11-35-27(34)16-25(33-35)21-4-2-9-31-18-21/h2,4-6,9-16,18,37H,3,7-8H2,1H3,(H,32,36)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239618
PNG
(US9394309, 71)
Show SMILES Fc1ccc(NC(=O)c2cc(cc(c2)S(F)(F)(F)(F)F)C#N)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C24H14F6N6OS/c25-20-4-3-18(33-24(37)17-8-15(13-31)9-19(10-17)38(26,27,28,29)30)11-22(20)35-6-7-36-23(35)12-21(34-36)16-2-1-5-32-14-16/h1-12,14H,(H,33,37)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239588
PNG
(US9394309, 41)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1ccc(C)c(c1)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C30H28F3N7O/c1-20-5-6-24(17-27(20)39-12-13-40-28(39)18-26(36-40)21-4-3-7-34-19-21)35-29(41)22-14-23(30(31,32)33)16-25(15-22)38-10-8-37(2)9-11-38/h3-7,12-19H,8-11H2,1-2H3,(H,35,41)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239663
PNG
(US9394309, 120)
Show SMILES Cc1ccc(NC(=O)c2cc(Br)cc(c2)S(F)(F)(F)(F)F)c(C)c1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C25H19BrF5N5OS/c1-15-5-6-21(33-25(37)18-10-19(26)12-20(11-18)38(27,28,29,30)31)16(2)24(15)35-8-9-36-23(35)13-22(34-36)17-4-3-7-32-14-17/h3-14H,1-2H3,(H,33,37)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239649
PNG
(US9394309, 105)
Show SMILES Cc1c(F)cc(NC(=O)c2cc(cc(c2)S(F)(F)(F)(F)F)C#N)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C25H16F6N6OS/c1-15-21(26)10-19(34-25(38)18-7-16(13-32)8-20(9-18)39(27,28,29,30)31)11-23(15)36-5-6-37-24(36)12-22(35-37)17-3-2-4-33-14-17/h2-12,14H,1H3,(H,34,38)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239635
PNG
(US9394309, 88)
Show SMILES Cc1ccc(NC(=O)c2cc(F)cc(c2)S(F)(F)(F)(F)F)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C24H17F6N5OS/c1-15-4-5-19(32-24(36)17-9-18(25)11-20(10-17)37(26,27,28,29)30)12-22(15)34-7-8-35-23(34)13-21(33-35)16-3-2-6-31-14-16/h2-14H,1H3,(H,32,36)
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Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH

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Assay Description
For measuring the autophosphorylation of the endogenous Tie2 receptor in the cell lysates prepared, a self-prepared anti-Tie2 antibody directed again...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239611
PNG
(US9394309, 64)
Show SMILES Cc1ccc(NC(=O)c2ccnc(c2)C(C)(C)C)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C27H26N6O/c1-18-7-8-21(30-26(34)19-9-11-29-24(14-19)27(2,3)4)15-23(18)32-12-13-33-25(32)16-22(31-33)20-6-5-10-28-17-20/h5-17H,1-4H3,(H,30,34)
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Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH

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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239671
PNG
(US9394309, 128)
Show SMILES Cc1cc(C)c(cc1NC(=O)c1cccc(OC(F)F)c1)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C26H21F2N5O2/c1-16-11-17(2)23(13-21(16)30-25(34)18-5-3-7-20(12-18)35-26(27)28)32-9-10-33-24(32)14-22(31-33)19-6-4-8-29-15-19/h3-15,26H,1-2H3,(H,30,34)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239632
PNG
(US9394309, 85)
Show SMILES Cc1ccc(NC(=O)c2cc(cc(c2)S(F)(F)(F)(F)F)C#N)cc1-n1ccn2nc(cc12)-c1cn[nH]c1
Show InChI InChI=1S/C23H16F5N7OS/c1-14-2-3-18(32-23(36)16-6-15(11-29)7-19(8-16)37(24,25,26,27)28)9-21(14)34-4-5-35-22(34)10-20(33-35)17-12-30-31-13-17/h2-10,12-13H,1H3,(H,30,31)(H,32,36)
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Assay Description
For measuring the autophosphorylation of the endogenous Tie2 receptor in the cell lysates prepared, a self-prepared anti-Tie2 antibody directed again...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239613
PNG
(US9394309, 66)
Show SMILES CNc1cc(cc(n1)C(C)(C)C)C(=O)Nc1ccc(C)c(c1)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C28H29N7O/c1-18-8-9-21(31-27(36)20-13-24(28(2,3)4)32-25(14-20)29-5)15-23(18)34-11-12-35-26(34)16-22(33-35)19-7-6-10-30-17-19/h6-17H,1-5H3,(H,29,32)(H,31,36)
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Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH

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Assay Description
For measuring the autophosphorylation of the endogenous Tie2 receptor in the cell lysates prepared, a self-prepared anti-Tie2 antibody directed again...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239642
PNG
(US9394309, 96)
Show SMILES FS(F)(F)(F)(F)c1cccc(c1)C(=O)Nc1ccc(Cl)c(c1)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C23H15ClF5N5OS/c24-19-7-6-17(31-23(35)15-3-1-5-18(11-15)36(25,26,27,28)29)12-21(19)33-9-10-34-22(33)13-20(32-34)16-4-2-8-30-14-16/h1-14H,(H,31,35)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239603
PNG
(US9394309, 56)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)N2CCCC2)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C28H26N6O/c1-20-9-10-23(30-28(35)21-6-4-8-24(16-21)32-12-2-3-13-32)17-26(20)33-14-15-34-27(33)18-25(31-34)22-7-5-11-29-19-22/h4-11,14-19H,2-3,12-13H2,1H3,(H,30,35)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239676
PNG
(US9394309, 133)
Show SMILES CC(C)COc1cccc(c1)C(=O)Nc1cc(c(C)cc1C)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C29H29N5O2/c1-19(2)18-36-24-9-5-7-22(14-24)29(35)31-25-15-27(21(4)13-20(25)3)33-11-12-34-28(33)16-26(32-34)23-8-6-10-30-17-23/h5-17,19H,18H2,1-4H3,(H,31,35)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239677
PNG
(US9394309, 134)
Show SMILES Cc1cc(C)c(cc1NC(=O)c1cccc(OC(C)(C)C)c1)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C29H29N5O2/c1-19-14-20(2)26(33-12-13-34-27(33)17-25(32-34)22-9-7-11-30-18-22)16-24(19)31-28(35)21-8-6-10-23(15-21)36-29(3,4)5/h6-18H,1-5H3,(H,31,35)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239666
PNG
(US9394309, 123)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(C)(C)C)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C28H27N5O/c1-19-10-11-23(30-27(34)20-7-5-9-22(15-20)28(2,3)4)16-25(19)32-13-14-33-26(32)17-24(31-33)21-8-6-12-29-18-21/h5-18H,1-4H3,(H,30,34)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239590
PNG
(US9394309, 43)
Show SMILES Cc1ccc(NC(=O)c2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C26H17F6N5O/c1-15-4-5-20(34-24(38)17-9-18(25(27,28)29)11-19(10-17)26(30,31)32)12-22(15)36-7-8-37-23(36)13-21(35-37)16-3-2-6-33-14-16/h2-14H,1H3,(H,34,38)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239614
PNG
(US9394309, 67)
Show SMILES Cc1ccc(NC(=O)c2ccnc(c2)N2CCCC2)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C27H25N7O/c1-19-6-7-22(30-27(35)20-8-10-29-25(15-20)32-11-2-3-12-32)16-24(19)33-13-14-34-26(33)17-23(31-34)21-5-4-9-28-18-21/h4-10,13-18H,2-3,11-12H2,1H3,(H,30,35)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239612
PNG
(US9394309, 65)
Show SMILES Cc1ccc(NC(=O)c2cc(Cl)nc(c2)C(C)(C)C)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C27H25ClN6O/c1-17-7-8-20(30-26(35)19-12-23(27(2,3)4)31-24(28)13-19)14-22(17)33-10-11-34-25(33)15-21(32-34)18-6-5-9-29-16-18/h5-16H,1-4H3,(H,30,35)
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Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH

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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239701
PNG
(US9394309, 158)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)S(F)(F)(F)(F)F)cc1-n1ccn2nc(c(F)c12)-c1cccnc1
Show InChI InChI=1S/C24H17F6N5OS/c1-15-7-8-18(32-23(36)16-4-2-6-19(12-16)37(26,27,28,29)30)13-20(15)34-10-11-35-24(34)21(25)22(33-35)17-5-3-9-31-14-17/h2-14H,1H3,(H,32,36)
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Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH

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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239684
PNG
(US9394309, 141)
Show SMILES Cc1cc(C)c(cc1NC(=O)c1cccc(c1)C(C)(C)O)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C28H27N5O2/c1-18-13-19(2)25(15-23(18)30-27(34)20-7-5-9-22(14-20)28(3,4)35)32-11-12-33-26(32)16-24(31-33)21-8-6-10-29-17-21/h5-17,35H,1-4H3,(H,30,34)
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Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH

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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239681
PNG
(US9394309, 138)
Show SMILES Cc1cc(C)c(cc1NC(=O)c1cccc(c1)N1CCC(F)(F)CC1)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C30H28F2N6O/c1-20-15-21(2)27(37-13-14-38-28(37)18-26(35-38)23-6-4-10-33-19-23)17-25(20)34-29(39)22-5-3-7-24(16-22)36-11-8-30(31,32)9-12-36/h3-7,10,13-19H,8-9,11-12H2,1-2H3,(H,34,39)
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Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH

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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239615
PNG
(US9394309, 68)
Show SMILES Cc1ccc(NC(=O)c2ccnc(c2)N2CCCCC2)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C28H27N7O/c1-20-7-8-23(31-28(36)21-9-11-30-26(16-21)33-12-3-2-4-13-33)17-25(20)34-14-15-35-27(34)18-24(32-35)22-6-5-10-29-19-22/h5-11,14-19H,2-4,12-13H2,1H3,(H,31,36)
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Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH

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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239623
PNG
(US9394309, 76)
Show SMILES Cc1ccc(cc1NC(=O)c1cccc(c1)S(F)(F)(F)(F)F)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C24H18F5N5OS/c1-16-7-8-19(33-10-11-34-23(33)14-22(32-34)18-5-3-9-30-15-18)13-21(16)31-24(35)17-4-2-6-20(12-17)36(25,26,27,28)29/h2-15H,1H3,(H,31,35)
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Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH

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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239637
PNG
(US9394309, 90)
Show SMILES COc1ccc(cc1C(=O)Nc1ccc(C)c(c1)-n1ccn2nc(cc12)-c1cccnc1)S(F)(F)(F)(F)F
Show InChI InChI=1S/C25H20F5N5O2S/c1-16-5-6-18(32-25(36)20-13-19(7-8-23(20)37-2)38(26,27,28,29)30)12-22(16)34-10-11-35-24(34)14-21(33-35)17-4-3-9-31-15-17/h3-15H,1-2H3,(H,32,36)
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Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH

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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239554
PNG
(US9394309, 7)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(C)(C)C)cc1-n1ccn2nc(cc12)-c1cn[nH]c1
Show InChI InChI=1S/C26H26N6O/c1-17-8-9-21(29-25(33)18-6-5-7-20(12-18)26(2,3)4)13-23(17)31-10-11-32-24(31)14-22(30-32)19-15-27-28-16-19/h5-16H,1-4H3,(H,27,28)(H,29,33)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239617
PNG
(US9394309, 70)
Show SMILES Fc1ccc(NC(=O)c2cccc(c2)S(F)(F)(F)(F)F)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C23H15F6N5OS/c24-19-7-6-17(31-23(35)15-3-1-5-18(11-15)36(25,26,27,28)29)12-21(19)33-9-10-34-22(33)13-20(32-34)16-4-2-8-30-14-16/h1-14H,(H,31,35)
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Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH

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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239630
PNG
(US9394309, 83)
Show SMILES Oc1c(NC(=O)c2cc(cc(c2)S(F)(F)(F)(F)F)C#N)cccc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C24H15F5N6O2S/c25-38(26,27,28,29)18-10-15(13-30)9-17(11-18)24(37)32-19-4-1-5-21(23(19)36)34-7-8-35-22(34)12-20(33-35)16-3-2-6-31-14-16/h1-12,14,36H,(H,32,37)
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Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH

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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239650
PNG
(US9394309, 106)
Show SMILES Cc1c(Cl)cc(NC(=O)c2cccc(c2)S(F)(F)(F)(F)F)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C24H17ClF5N5OS/c1-15-20(25)11-18(32-24(36)16-4-2-6-19(10-16)37(26,27,28,29)30)12-22(15)34-8-9-35-23(34)13-21(33-35)17-5-3-7-31-14-17/h2-14H,1H3,(H,32,36)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239662
PNG
(US9394309, 119)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)S(F)(F)(F)(F)F)c(C)c1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C25H20F5N5OS/c1-16-8-9-21(32-25(36)18-5-3-7-20(13-18)37(26,27,28,29)30)17(2)24(16)34-11-12-35-23(34)14-22(33-35)19-6-4-10-31-15-19/h3-15H,1-2H3,(H,32,36)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239625
PNG
(US9394309, 78)
Show SMILES Cc1ccc(cc1NC(=O)c1cc(Br)cc(c1)C(C)(C)C)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C28H26BrN5O/c1-18-7-8-23(33-10-11-34-26(33)16-25(32-34)19-6-5-9-30-17-19)15-24(18)31-27(35)20-12-21(28(2,3)4)14-22(29)13-20/h5-17H,1-4H3,(H,31,35)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239607
PNG
(US9394309, 60)
Show SMILES CC(C)Oc1cccc(c1)C(=O)Nc1ccc(C)c(c1)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C27H25N5O2/c1-18(2)34-23-8-4-6-20(14-23)27(33)29-22-10-9-19(3)25(15-22)31-12-13-32-26(31)16-24(30-32)21-7-5-11-28-17-21/h4-18H,1-3H3,(H,29,33)
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Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH

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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239648
PNG
(US9394309, 103)
Show SMILES Cc1c(F)cc(NC(=O)c2cccc(c2)S(F)(F)(F)(F)F)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C24H17F6N5OS/c1-15-20(25)11-18(32-24(36)16-4-2-6-19(10-16)37(26,27,28,29)30)12-22(15)34-8-9-35-23(34)13-21(33-35)17-5-3-7-31-14-17/h2-14H,1H3,(H,32,36)
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Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH

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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239591
PNG
(US9394309, 44)
Show SMILES Cc1ccc(NC(=O)c2cc(cc(c2)C(F)(F)F)C#N)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C26H17F3N6O/c1-16-4-5-21(32-25(36)19-9-17(14-30)10-20(11-19)26(27,28)29)12-23(16)34-7-8-35-24(34)13-22(33-35)18-3-2-6-31-15-18/h2-13,15H,1H3,(H,32,36)
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Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH

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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239646
PNG
(US9394309, 100)
Show SMILES Cc1cc(NC(=O)c2cccc(c2)S(F)(F)(F)(F)F)cc(c1C)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C25H20F5N5OS/c1-16-11-20(32-25(36)18-5-3-7-21(12-18)37(26,27,28,29)30)13-23(17(16)2)34-9-10-35-24(34)14-22(33-35)19-6-4-8-31-15-19/h3-15H,1-2H3,(H,32,36)
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Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH

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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239638
PNG
(US9394309, 91)
Show SMILES Cc1ccc(cc1C(=O)Nc1ccc(C)c(c1)-n1ccn2nc(cc12)-c1cccnc1)S(F)(F)(F)(F)F
Show InChI InChI=1S/C25H20F5N5OS/c1-16-6-8-20(37(26,27,28,29)30)13-21(16)25(36)32-19-7-5-17(2)23(12-19)34-10-11-35-24(34)14-22(33-35)18-4-3-9-31-15-18/h3-15H,1-2H3,(H,32,36)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239631
PNG
(US9394309, 84)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)S(F)(F)(F)(F)F)cc1-n1ccn2nc(cc12)-c1cnccn1
Show InChI InChI=1S/C23H17F5N6OS/c1-15-5-6-17(31-23(35)16-3-2-4-18(11-16)36(24,25,26,27)28)12-21(15)33-9-10-34-22(33)13-19(32-34)20-14-29-7-8-30-20/h2-14H,1H3,(H,31,35)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239599
PNG
(US9394309, 52)
Show SMILES Cc1cc(C)cc(c1)C(=O)Nc1ccc(C)c(c1)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C26H23N5O/c1-17-11-18(2)13-21(12-17)26(32)28-22-7-6-19(3)24(14-22)30-9-10-31-25(30)15-23(29-31)20-5-4-8-27-16-20/h4-16H,1-3H3,(H,28,32)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239645
PNG
(US9394309, 99)
Show SMILES COc1ccc(NC(=O)c2cc(cc(c2)S(F)(F)(F)(F)F)C#N)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C25H17F5N6O2S/c1-38-23-5-4-19(33-25(37)18-9-16(14-31)10-20(11-18)39(26,27,28,29)30)12-22(23)35-7-8-36-24(35)13-21(34-36)17-3-2-6-32-15-17/h2-13,15H,1H3,(H,33,37)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239629
PNG
(US9394309, 82)
Show SMILES Oc1c(NC(=O)c2cccc(c2)S(F)(F)(F)(F)F)cccc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C23H16F5N5O2S/c24-36(25,26,27,28)17-6-1-4-15(12-17)23(35)30-18-7-2-8-20(22(18)34)32-10-11-33-21(32)13-19(31-33)16-5-3-9-29-14-16/h1-14,34H,(H,30,35)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239674
PNG
(US9394309, 131)
Show SMILES COc1cccc(c1)C(=O)Nc1cc(c(C)cc1C)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C26H23N5O2/c1-17-12-18(2)24(14-22(17)28-26(32)19-6-4-8-21(13-19)33-3)30-10-11-31-25(30)15-23(29-31)20-7-5-9-27-16-20/h4-16H,1-3H3,(H,28,32)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239608
PNG
(US9394309, 61)
Show SMILES CCCOc1cccc(c1)C(=O)Nc1ccc(C)c(c1)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C27H25N5O2/c1-3-14-34-23-8-4-6-20(15-23)27(33)29-22-10-9-19(2)25(16-22)31-12-13-32-26(31)17-24(30-32)21-7-5-11-28-18-21/h4-13,15-18H,3,14H2,1-2H3,(H,29,33)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239602
PNG
(US9394309, 55)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)-n2cccn2)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C27H21N7O/c1-19-8-9-22(30-27(35)20-5-2-7-23(15-20)33-12-4-11-29-33)16-25(19)32-13-14-34-26(32)17-24(31-34)21-6-3-10-28-18-21/h2-18H,1H3,(H,30,35)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239668
PNG
(US9394309, 125)
Show SMILES Cc1ccc(NC(=O)c2cc(ccn2)C(C)(C)C)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C27H26N6O/c1-18-7-8-21(30-26(34)23-14-20(9-11-29-23)27(2,3)4)15-24(18)32-12-13-33-25(32)16-22(31-33)19-6-5-10-28-17-19/h5-17H,1-4H3,(H,30,34)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239667
PNG
(US9394309, 124)
Show SMILES Cc1cc(cc(c1)S(N)(=O)=O)C(=O)Nc1ccc(C)c(c1)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C25H22N6O3S/c1-16-10-19(12-21(11-16)35(26,33)34)25(32)28-20-6-5-17(2)23(13-20)30-8-9-31-24(30)14-22(29-31)18-4-3-7-27-15-18/h3-15H,1-2H3,(H,28,32)(H2,26,33,34)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239586
PNG
(US9394309, 39)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C25H18F3N5O/c1-16-7-8-20(30-24(34)17-4-2-6-19(12-17)25(26,27)28)13-22(16)32-10-11-33-23(32)14-21(31-33)18-5-3-9-29-15-18/h2-15H,1H3,(H,30,34)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239605
PNG
(US9394309, 58)
Show SMILES Cc1ccc(NC(=O)c2ccc(Cl)c(c2)N2CCCCC2)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C29H27ClN6O/c1-20-7-9-23(32-29(37)21-8-10-24(30)27(16-21)34-12-3-2-4-13-34)17-26(20)35-14-15-36-28(35)18-25(33-36)22-6-5-11-31-19-22/h5-11,14-19H,2-4,12-13H2,1H3,(H,32,37)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239600
PNG
(US9394309, 53)
Show SMILES CC(C)c1ccc(O)c(c1)C(=O)Nc1ccc(C)c(c1)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C27H25N5O2/c1-17(2)19-7-9-25(33)22(13-19)27(34)29-21-8-6-18(3)24(14-21)31-11-12-32-26(31)15-23(30-32)20-5-4-10-28-16-20/h4-17,33H,1-3H3,(H,29,34)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239641
PNG
(US9394309, 95)
Show SMILES FC(F)(F)c1ccc(NC(=O)c2cc(cc(c2)S(F)(F)(F)(F)F)C#N)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C25H14F8N6OS/c26-25(27,28)20-4-3-18(36-24(40)17-8-15(13-34)9-19(10-17)41(29,30,31,32)33)11-22(20)38-6-7-39-23(38)12-21(37-39)16-2-1-5-35-14-16/h1-12,14H,(H,36,40)
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For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239619
PNG
(US9394309, 72)
Show SMILES COc1ccc(NC(=O)c2cccc(c2)S(F)(F)(F)(F)F)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C24H18F5N5O2S/c1-36-22-8-7-18(31-24(35)16-4-2-6-19(12-16)37(25,26,27,28)29)13-21(22)33-10-11-34-23(33)14-20(32-34)17-5-3-9-30-15-17/h2-15H,1H3,(H,31,35)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239552
PNG
(US9394309, 5)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-n1ccn2nc(cc12)-c1cn[nH]c1
Show InChI InChI=1S/C23H17F3N6O/c1-14-5-6-18(29-22(33)15-3-2-4-17(9-15)23(24,25)26)10-20(14)31-7-8-32-21(31)11-19(30-32)16-12-27-28-13-16/h2-13H,1H3,(H,27,28)(H,29,33)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239680
PNG
(US9394309, 137)
Show SMILES CN(C)CCOc1cccc(c1)C(=O)Nc1cc(c(C)cc1C)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C29H30N6O2/c1-20-15-21(2)27(34-11-12-35-28(34)18-26(32-35)23-8-6-10-30-19-23)17-25(20)31-29(36)22-7-5-9-24(16-22)37-14-13-33(3)4/h5-12,15-19H,13-14H2,1-4H3,(H,31,36)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239628
PNG
(US9394309, 81)
Show SMILES Fc1c(NC(=O)c2cc(cc(c2)S(F)(F)(F)(F)F)C#N)cccc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C24H14F6N6OS/c25-23-19(33-24(37)17-9-15(13-31)10-18(11-17)38(26,27,28,29)30)4-1-5-21(23)35-7-8-36-22(35)12-20(34-36)16-3-2-6-32-14-16/h1-12,14H,(H,33,37)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239609
PNG
(US9394309, 62)
Show SMILES CC(C)COc1cccc(c1)C(=O)Nc1ccc(C)c(c1)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C28H27N5O2/c1-19(2)18-35-24-8-4-6-21(14-24)28(34)30-23-10-9-20(3)26(15-23)32-12-13-33-27(32)16-25(31-33)22-7-5-11-29-17-22/h4-17,19H,18H2,1-3H3,(H,30,34)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239616
PNG
(US9394309, 69)
Show SMILES Cc1ccc(NC(=O)c2ccnc(c2)N2CCOCC2)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C27H25N7O2/c1-19-4-5-22(30-27(35)20-6-8-29-25(15-20)32-11-13-36-14-12-32)16-24(19)33-9-10-34-26(33)17-23(31-34)21-3-2-7-28-18-21/h2-10,15-18H,11-14H2,1H3,(H,30,35)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239644
PNG
(US9394309, 98)
Show SMILES COc1ccc(NC(=O)c2cc(Br)cc(c2)S(F)(F)(F)(F)F)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C24H17BrF5N5O2S/c1-37-22-5-4-18(32-24(36)16-9-17(25)11-19(10-16)38(26,27,28,29)30)12-21(22)34-7-8-35-23(34)13-20(33-35)15-3-2-6-31-14-15/h2-14H,1H3,(H,32,36)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239606
PNG
(US9394309, 59)
Show SMILES CN(C)c1cccc(c1)C(=O)Nc1ccc(C)c(c1)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C26H24N6O/c1-18-9-10-21(28-26(33)19-6-4-8-22(14-19)30(2)3)15-24(18)31-12-13-32-25(31)16-23(29-32)20-7-5-11-27-17-20/h4-17H,1-3H3,(H,28,33)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239678
PNG
(US9394309, 135)
Show SMILES CCOCCOc1cccc(c1)C(=O)Nc1cc(c(C)cc1C)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C29H29N5O3/c1-4-36-13-14-37-24-9-5-7-22(16-24)29(35)31-25-17-27(21(3)15-20(25)2)33-11-12-34-28(33)18-26(32-34)23-8-6-10-30-19-23/h5-12,15-19H,4,13-14H2,1-3H3,(H,31,35)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239601
PNG
(US9394309, 54)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)-c2cccc(c2)C#N)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C31H22N6O/c1-21-10-11-27(34-31(38)25-8-3-7-24(16-25)23-6-2-5-22(15-23)19-32)17-29(21)36-13-14-37-30(36)18-28(35-37)26-9-4-12-33-20-26/h2-18,20H,1H3,(H,34,38)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239679
PNG
(US9394309, 136)
Show SMILES Cc1cc(C)c(cc1NC(=O)c1cccc(OCCO)c1)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C27H25N5O3/c1-18-13-19(2)25(15-23(18)29-27(34)20-5-3-7-22(14-20)35-12-11-33)31-9-10-32-26(31)16-24(30-32)21-6-4-8-28-17-21/h3-10,13-17,33H,11-12H2,1-2H3,(H,29,34)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239627
PNG
(US9394309, 80)
Show SMILES Cc1c(NC(=O)c2cc(cc(c2)S(F)(F)(F)(F)F)C#N)cccc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C25H17F5N6OS/c1-16-21(33-25(37)19-10-17(14-31)11-20(12-19)38(26,27,28,29)30)5-2-6-23(16)35-8-9-36-24(35)13-22(34-36)18-4-3-7-32-15-18/h2-13,15H,1H3,(H,33,37)
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Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239709
PNG
(US9394309, 168)
Show SMILES Cc1ccc(NC(=O)c2cc(cc(c2)S(F)(F)(F)(F)F)C#N)cc1-n1ccn2nc(cc12)-c1ccnnc1
Show InChI InChI=1S/C24H16F5N7OS/c1-15-2-3-19(33-24(37)18-8-16(13-30)9-20(10-18)38(25,26,27,28)29)11-22(15)35-6-7-36-23(35)12-21(34-36)17-4-5-31-32-14-17/h2-12,14H,1H3,(H,33,37)
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n/an/a 726n/an/an/an/an/an/a



Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239592
PNG
(US9394309, 45)
Show SMILES Cc1ccc(NC(=O)c2ccc(F)c(c2)C(F)(F)F)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C25H17F4N5O/c1-15-4-6-18(31-24(35)16-5-7-20(26)19(11-16)25(27,28)29)12-22(15)33-9-10-34-23(33)13-21(32-34)17-3-2-8-30-14-17/h2-14H,1H3,(H,31,35)
PDB

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n/an/a 740n/an/an/an/an/an/a



Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239610
PNG
(US9394309, 63)
Show SMILES COc1cc(OC)cc(c1)C(=O)Nc1ccc(C)c(c1)-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C26H23N5O3/c1-17-6-7-20(28-26(32)19-11-21(33-2)14-22(12-19)34-3)13-24(17)30-9-10-31-25(30)15-23(29-31)18-5-4-8-27-16-18/h4-16H,1-3H3,(H,28,32)
PDB

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n/an/a 770n/an/an/an/an/an/a



Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239634
PNG
(US9394309, 87)
Show SMILES FS(F)(F)(F)(F)c1cc(cc(c1)C(=O)Nc1cccc(c1)-n1ccn2nc(cc12)-c1cccnc1)C#N
Show InChI InChI=1S/C24H15F5N6OS/c25-37(26,27,28,29)21-10-16(14-30)9-18(11-21)24(36)32-19-4-1-5-20(12-19)34-7-8-35-23(34)13-22(33-35)17-3-2-6-31-15-17/h1-13,15H,(H,32,36)
PDB

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US Patent
n/an/a 980n/an/an/an/an/an/a



Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239593
PNG
(US9394309, 46)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2F)C(F)(F)F)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C25H17F4N5O/c1-15-7-8-17(31-24(35)18-5-2-6-19(23(18)26)25(27,28)29)12-21(15)33-10-11-34-22(33)13-20(32-34)16-4-3-9-30-14-16/h2-14H,1H3,(H,31,35)
PDB

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UniChem
US Patent
n/an/a 980n/an/an/an/an/an/a



Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TIE-2


(Homo sapiens (Human))
BDBM239604
PNG
(US9394309, 57)
Show SMILES Cc1ccc(NC(=O)c2cc(ccc2Cl)N2CCCC2)cc1-n1ccn2nc(cc12)-c1cccnc1
Show InChI InChI=1S/C28H25ClN6O/c1-19-6-7-21(31-28(36)23-16-22(8-9-24(23)29)33-11-2-3-12-33)15-26(19)34-13-14-35-27(34)17-25(32-35)20-5-4-10-30-18-20/h4-10,13-18H,2-3,11-12H2,1H3,(H,31,36)
PDB

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US Patent
n/an/a 995n/an/an/an/an/an/a



Bayer Pharma Aktiengesellschaft; Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%