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Patent code US9403767

Compile Data Set for Download or QSAR
Found 182 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nociceptin receptor


(Homo sapiens (human))
BDBM239934
PNG
(US9403767, 117)
Show SMILES CN(C)C1(CCC(CC1)(N(C)C(=O)c1cccc(F)c1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C28H31FN2O/c1-30(2)27(23-12-6-4-7-13-23)17-19-28(20-18-27,24-14-8-5-9-15-24)31(3)26(32)22-11-10-16-25(29)21-22/h4-16,21H,17-20H2,1-3H3
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US Patent
0.130n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239934
PNG
(US9403767, 117)
Show SMILES CN(C)C1(CCC(CC1)(N(C)C(=O)c1cccc(F)c1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C28H31FN2O/c1-30(2)27(23-12-6-4-7-13-23)17-19-28(20-18-27,24-14-8-5-9-15-24)31(3)26(32)22-11-10-16-25(29)21-22/h4-16,21H,17-20H2,1-3H3
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0.350n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239911
PNG
(US9403767, 76 | US9403767, 77)
Show SMILES CN(CC1(C)CCC(CC1)(N(C)C)c1ccccc1)c1c[nH]c2ccccc12
Show InChI InChI=1S/C25H33N3/c1-24(19-28(4)23-18-26-22-13-9-8-12-21(22)23)14-16-25(17-15-24,27(2)3)20-10-6-5-7-11-20/h5-13,18,26H,14-17,19H2,1-4H3
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GRUENENTHAL GMBH

US Patent


Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239921
PNG
(US9403767, 99)
Show SMILES CN(C)C1(CCC(CC1)(N(C)C(=O)c1cccc(c1)C(F)(F)F)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C29H31F3N2O/c1-33(2)27(23-12-6-4-7-13-23)17-19-28(20-18-27,24-14-8-5-9-15-24)34(3)26(35)22-11-10-16-25(21-22)29(30,31)32/h4-16,21H,17-20H2,1-3H3
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GRUENENTHAL GMBH

US Patent


Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239925
PNG
(US9403767, 104 | US9403767, 105)
Show SMILES COc1ccc(cc1)C(=O)N(C)C1(CCC(CC1)(N(C)C)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C29H34N2O2/c1-30(2)28(24-11-7-5-8-12-24)19-21-29(22-20-28,25-13-9-6-10-14-25)31(3)27(32)23-15-17-26(33-4)18-16-23/h5-18H,19-22H2,1-4H3
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0.650n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239911
PNG
(US9403767, 76 | US9403767, 77)
Show SMILES CN(CC1(C)CCC(CC1)(N(C)C)c1ccccc1)c1c[nH]c2ccccc12
Show InChI InChI=1S/C25H33N3/c1-24(19-28(4)23-18-26-22-13-9-8-12-21(22)23)14-16-25(17-15-24,27(2)3)20-10-6-5-7-11-20/h5-13,18,26H,14-17,19H2,1-4H3
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GRUENENTHAL GMBH

US Patent


Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239914
PNG
(US9403767, 85)
Show SMILES CN(C)C1(CCC(CC1)(N(C)Cc1cccnc1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C27H33N3/c1-29(2)26(24-12-6-4-7-13-24)16-18-27(19-17-26,25-14-8-5-9-15-25)30(3)22-23-11-10-20-28-21-23/h4-15,20-21H,16-19,22H2,1-3H3
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0.810n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239867
PNG
(US9403767, 20 | US9403767, 21)
Show SMILES CN(C)C1(CCC(CO)(CCCCc2ccccc2)CC1)c1ccccc1
Show InChI InChI=1S/C25H35NO/c1-26(2)25(23-14-7-4-8-15-23)19-17-24(21-27,18-20-25)16-10-9-13-22-11-5-3-6-12-22/h3-8,11-12,14-15,27H,9-10,13,16-21H2,1-2H3
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GRUENENTHAL GMBH

US Patent


Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239925
PNG
(US9403767, 104 | US9403767, 105)
Show SMILES COc1ccc(cc1)C(=O)N(C)C1(CCC(CC1)(N(C)C)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C29H34N2O2/c1-30(2)28(24-11-7-5-8-12-24)19-21-29(22-20-28,25-13-9-6-10-14-25)31(3)27(32)23-15-17-26(33-4)18-16-23/h5-18H,19-22H2,1-4H3
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US Patent


Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239921
PNG
(US9403767, 99)
Show SMILES CN(C)C1(CCC(CC1)(N(C)C(=O)c1cccc(c1)C(F)(F)F)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C29H31F3N2O/c1-33(2)27(23-12-6-4-7-13-23)17-19-28(20-18-27,24-14-8-5-9-15-24)34(3)26(35)22-11-10-16-25(21-22)29(30,31)32/h4-16,21H,17-20H2,1-3H3
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GRUENENTHAL GMBH

US Patent


Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239887
PNG
(US9403767, 45)
Show SMILES CN(C)C1(CCC(C)(CNS(=O)(=O)\C=C\c2ccccc2)CC1)c1cccc(F)c1
Show InChI InChI=1S/C24H31FN2O2S/c1-23(19-26-30(28,29)17-12-20-8-5-4-6-9-20)13-15-24(16-14-23,27(2)3)21-10-7-11-22(25)18-21/h4-12,17-18,26H,13-16,19H2,1-3H3/b17-12+
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GRUENENTHAL GMBH

US Patent


Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239865
PNG
(US9403767, 18)
Show SMILES CN(C)C1(CCC(C)(CNS(=O)(=O)c2ccc(Cl)cc2)CC1)c1ccccc1
Show InChI InChI=1S/C22H29ClN2O2S/c1-21(17-24-28(26,27)20-11-9-19(23)10-12-20)13-15-22(16-14-21,25(2)3)18-7-5-4-6-8-18/h4-12,24H,13-17H2,1-3H3
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GRUENENTHAL GMBH

US Patent


Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239892
PNG
(US9403767, 50 | US9403767, 51)
Show SMILES CN(C)C1(CCC(CC1)(N(C)Cc1ccccc1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C28H34N2/c1-29(2)27(25-15-9-5-10-16-25)19-21-28(22-20-27,26-17-11-6-12-18-26)30(3)23-24-13-7-4-8-14-24/h4-18H,19-23H2,1-3H3
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GRUENENTHAL GMBH

US Patent


Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239935
PNG
(US9403767, 119)
Show SMILES CN(C)C1(CCC(CC1)(N(C)Cc1cccc(F)c1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C28H33FN2/c1-30(2)27(24-12-6-4-7-13-24)17-19-28(20-18-27,25-14-8-5-9-15-25)31(3)22-23-11-10-16-26(29)21-23/h4-16,21H,17-20,22H2,1-3H3
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GRUENENTHAL GMBH

US Patent


Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239873
PNG
(US9403767, 29 | US9403767, 30)
Show SMILES CN(C)C1(CCC(CC1)(N(C)C(=O)NCc1ccccc1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C29H35N3O/c1-31(2)28(25-15-9-5-10-16-25)19-21-29(22-20-28,26-17-11-6-12-18-26)32(3)27(33)30-23-24-13-7-4-8-14-24/h4-18H,19-23H2,1-3H3,(H,30,33)
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GRUENENTHAL GMBH

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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239890
PNG
(US9403767, 48 | US9403767, 49)
Show SMILES CCCCN(C)C1(CCC(CC1)(N(C)C)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H36N2/c1-5-6-21-27(4)25(23-15-11-8-12-16-23)19-17-24(18-20-25,26(2)3)22-13-9-7-10-14-22/h7-16H,5-6,17-21H2,1-4H3
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239873
PNG
(US9403767, 29 | US9403767, 30)
Show SMILES CN(C)C1(CCC(CC1)(N(C)C(=O)NCc1ccccc1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C29H35N3O/c1-31(2)28(25-15-9-5-10-16-25)19-21-29(22-20-28,26-17-11-6-12-18-26)32(3)27(33)30-23-24-13-7-4-8-14-24/h4-18H,19-23H2,1-3H3,(H,30,33)
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239884
PNG
(US9403767, 42)
Show SMILES CN(C)C1(CCC(C)(CNC(=O)\C=C\c2ccccc2)CC1)c1cccc(F)c1
Show InChI InChI=1S/C25H31FN2O/c1-24(19-27-23(29)13-12-20-8-5-4-6-9-20)14-16-25(17-15-24,28(2)3)21-10-7-11-22(26)18-21/h4-13,18H,14-17,19H2,1-3H3,(H,27,29)/b13-12+
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239873
PNG
(US9403767, 29 | US9403767, 30)
Show SMILES CN(C)C1(CCC(CC1)(N(C)C(=O)NCc1ccccc1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C29H35N3O/c1-31(2)28(25-15-9-5-10-16-25)19-21-29(22-20-28,26-17-11-6-12-18-26)32(3)27(33)30-23-24-13-7-4-8-14-24/h4-18H,19-23H2,1-3H3,(H,30,33)
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239923
PNG
(US9403767, 101 | US9403767, 102)
Show SMILES CN(C)C1(CCC(CC1)(N(C)Cc1ccn(C)n1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C26H34N4/c1-28(2)25(22-11-7-5-8-12-22)16-18-26(19-17-25,23-13-9-6-10-14-23)29(3)21-24-15-20-30(4)27-24/h5-15,20H,16-19,21H2,1-4H3
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2.45n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239865
PNG
(US9403767, 18)
Show SMILES CN(C)C1(CCC(C)(CNS(=O)(=O)c2ccc(Cl)cc2)CC1)c1ccccc1
Show InChI InChI=1S/C22H29ClN2O2S/c1-21(17-24-28(26,27)20-11-9-19(23)10-12-20)13-15-22(16-14-21,25(2)3)18-7-5-4-6-8-18/h4-12,24H,13-17H2,1-3H3
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2.70n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239947
PNG
(US9403767, C-2)
Show SMILES CN(C)C1(CCC(O)(CC1)c1ccccc1)c1ccc(C)cc1
Show InChI InChI=1S/C21H27NO/c1-17-9-11-18(12-10-17)20(22(2)3)13-15-21(23,16-14-20)19-7-5-4-6-8-19/h4-12,23H,13-16H2,1-3H3
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3n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239869
PNG
(US9403767, 24 | US9403767, 27)
Show SMILES CN(C)C1(CCC(CC1)(N(C)C(=O)\C=C\c1ccccc1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C30H34N2O/c1-31(2)29(26-15-9-5-10-16-26)21-23-30(24-22-29,27-17-11-6-12-18-27)32(3)28(33)20-19-25-13-7-4-8-14-25/h4-20H,21-24H2,1-3H3/b20-19+
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4.90n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239901
PNG
(US9403767, 64 | US9403767, 65)
Show SMILES CN(C)C1(CC2CCCC2)CCC(CC1)(N(C)C(=O)\C=C\c1ccccc1)c1ccccc1
Show InChI InChI=1S/C30H40N2O/c1-31(2)29(24-26-14-10-11-15-26)20-22-30(23-21-29,27-16-8-5-9-17-27)32(3)28(33)19-18-25-12-6-4-7-13-25/h4-9,12-13,16-19,26H,10-11,14-15,20-24H2,1-3H3/b19-18+
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5.30n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239917
PNG
(US9403767, 91)
Show SMILES CNc1nc(Oc2ccc(OC)cc2)nc(n1)N(C)C1(CCC(CC1)(N(C)C)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C32H38N6O2/c1-33-28-34-29(36-30(35-28)40-27-18-16-26(39-5)17-19-27)38(4)32(25-14-10-7-11-15-25)22-20-31(21-23-32,37(2)3)24-12-8-6-9-13-24/h6-19H,20-23H2,1-5H3,(H,33,34,35,36)
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239861
PNG
(US9403767, 11)
Show SMILES CN(C)C1(CCC(CC1)(N(C)C)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C22H30N2/c1-23(2)21(19-11-7-5-8-12-19)15-17-22(18-16-21,24(3)4)20-13-9-6-10-14-20/h5-14H,15-18H2,1-4H3
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239918
PNG
(US9403767, 92 | US9403767, 93)
Show SMILES CN(C)C1(CCC(CC1)(N(C)C(=O)c1ccn(C)n1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C26H32N4O/c1-28(2)25(21-11-7-5-8-12-21)16-18-26(19-17-25,22-13-9-6-10-14-22)30(4)24(31)23-15-20-29(3)27-23/h5-15,20H,16-19H2,1-4H3
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239900
PNG
(US9403767, 63)
Show SMILES CN(C)C1(CC2CCCC2)CCC(CC1)(N(C)C)c1ccccc1
Show InChI InChI=1S/C22H36N2/c1-23(2)21(18-19-10-8-9-11-19)14-16-22(17-15-21,24(3)4)20-12-6-5-7-13-20/h5-7,12-13,19H,8-11,14-18H2,1-4H3
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239938
PNG
(US9403767, 122)
Show SMILES CNC(=O)CN(C)C1(CCC(CC1)(N(C)C)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H33N3O/c1-25-22(28)19-27(4)24(21-13-9-6-10-14-21)17-15-23(16-18-24,26(2)3)20-11-7-5-8-12-20/h5-14H,15-19H2,1-4H3,(H,25,28)
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7.40n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239869
PNG
(US9403767, 24 | US9403767, 27)
Show SMILES CN(C)C1(CCC(CC1)(N(C)C(=O)\C=C\c1ccccc1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C30H34N2O/c1-31(2)29(26-15-9-5-10-16-26)21-23-30(24-22-29,27-17-11-6-12-18-27)32(3)28(33)20-19-25-13-7-4-8-14-25/h4-20H,21-24H2,1-3H3/b20-19+
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GRUENENTHAL GMBH

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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239894
PNG
(US9403767, 52)
Show SMILES CN(C)C1(CCC(CC1)(N(C)C(=O)C(c1ccccc1)c1ccccc1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C35H38N2O/c1-36(2)34(30-20-12-6-13-21-30)24-26-35(27-25-34,31-22-14-7-15-23-31)37(3)33(38)32(28-16-8-4-9-17-28)29-18-10-5-11-19-29/h4-23,32H,24-27H2,1-3H3
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239925
PNG
(US9403767, 104 | US9403767, 105)
Show SMILES COc1ccc(cc1)C(=O)N(C)C1(CCC(CC1)(N(C)C)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C29H34N2O2/c1-30(2)28(24-11-7-5-8-12-24)19-21-29(22-20-28,25-13-9-6-10-14-25)31(3)27(32)23-15-17-26(33-4)18-16-23/h5-18H,19-22H2,1-4H3
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239867
PNG
(US9403767, 20 | US9403767, 21)
Show SMILES CN(C)C1(CCC(CO)(CCCCc2ccccc2)CC1)c1ccccc1
Show InChI InChI=1S/C25H35NO/c1-26(2)25(23-14-7-4-8-15-23)19-17-24(21-27,18-20-25)16-10-9-13-22-11-5-3-6-12-22/h3-8,11-12,14-15,27H,9-10,13,16-21H2,1-2H3
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239886
PNG
(US9403767, 44)
Show SMILES CN(C)C1(CCC(C)(CNS(=O)(=O)\C=C\c2ccccc2)CC1)c1cccc(F)c1
Show InChI InChI=1S/C24H31FN2O2S/c1-23(19-26-30(28,29)17-12-20-8-5-4-6-9-20)13-15-24(16-14-23,27(2)3)21-10-7-11-22(25)18-21/h4-12,17-18,26H,13-16,19H2,1-3H3/b17-12+
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239931
PNG
(US9403767, 114)
Show SMILES CN(C)C1(CCC(CC1)(N(C)Cc1cccc(c1)C(F)(F)F)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C29H33F3N2/c1-33(2)27(24-12-6-4-7-13-24)17-19-28(20-18-27,25-14-8-5-9-15-25)34(3)22-23-11-10-16-26(21-23)29(30,31)32/h4-16,21H,17-20,22H2,1-3H3
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239933
PNG
(US9403767, 116)
Show SMILES CN(C)C1(CCC(CC1)(N(C)C(=O)c1cccc(F)c1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C28H31FN2O/c1-30(2)27(23-12-6-4-7-13-23)17-19-28(20-18-27,24-14-8-5-9-15-24)31(3)26(32)22-11-10-16-25(29)21-22/h4-16,21H,17-20H2,1-3H3
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239869
PNG
(US9403767, 24 | US9403767, 27)
Show SMILES CN(C)C1(CCC(CC1)(N(C)C(=O)\C=C\c1ccccc1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C30H34N2O/c1-31(2)29(26-15-9-5-10-16-26)21-23-30(24-22-29,27-17-11-6-12-18-27)32(3)28(33)20-19-25-13-7-4-8-14-25/h4-20H,21-24H2,1-3H3/b20-19+
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239918
PNG
(US9403767, 92 | US9403767, 93)
Show SMILES CN(C)C1(CCC(CC1)(N(C)C(=O)c1ccn(C)n1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C26H32N4O/c1-28(2)25(21-11-7-5-8-12-21)16-18-26(19-17-25,22-13-9-6-10-14-22)30(4)24(31)23-15-20-29(3)27-23/h5-15,20H,16-19H2,1-4H3
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239870
PNG
(US9403767, 25 | US9403767, 28)
Show SMILES CN(C)C1(CCC(CC1)(N(C)C(C)=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H30N2O/c1-19(26)25(4)23(21-13-9-6-10-14-21)17-15-22(16-18-23,24(2)3)20-11-7-5-8-12-20/h5-14H,15-18H2,1-4H3
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239866
PNG
(US9403767, 19)
Show SMILES CCCCC1(CNS(=O)(=O)c2ccc(Cl)cc2)CCC(CC1)(N(C)C)c1ccccc1
Show InChI InChI=1S/C25H35ClN2O2S/c1-4-5-15-24(20-27-31(29,30)23-13-11-22(26)12-14-23)16-18-25(19-17-24,28(2)3)21-9-7-6-8-10-21/h6-14,27H,4-5,15-20H2,1-3H3
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239860
PNG
(US9403767, 9)
Show SMILES CNC1(CCC(CC1)(N(C)C)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C21H28N2/c1-22-20(18-10-6-4-7-11-18)14-16-21(17-15-20,23(2)3)19-12-8-5-9-13-19/h4-13,22H,14-17H2,1-3H3
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239943
PNG
(US9403767, 130)
Show SMILES CN(C)C1(CCC(CC1)(N(C)CCCCO)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H36N2O/c1-26(2)24(22-12-6-4-7-13-22)16-18-25(19-17-24,23-14-8-5-9-15-23)27(3)20-10-11-21-28/h4-9,12-15,28H,10-11,16-21H2,1-3H3
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239894
PNG
(US9403767, 52)
Show SMILES CN(C)C1(CCC(CC1)(N(C)C(=O)C(c1ccccc1)c1ccccc1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C35H38N2O/c1-36(2)34(30-20-12-6-13-21-30)24-26-35(27-25-34,31-22-14-7-15-23-31)37(3)33(38)32(28-16-8-4-9-17-28)29-18-10-5-11-19-29/h4-23,32H,24-27H2,1-3H3
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239927
PNG
(US9403767, 106)
Show SMILES COc1ccc(CN(C)C2(CCC(CC2)(N(C)C)c2ccccc2)c2ccccc2)cc1
Show InChI InChI=1S/C29H36N2O/c1-30(2)28(25-11-7-5-8-12-25)19-21-29(22-20-28,26-13-9-6-10-14-26)31(3)23-24-15-17-27(32-4)18-16-24/h5-18H,19-23H2,1-4H3
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239933
PNG
(US9403767, 116)
Show SMILES CN(C)C1(CCC(CC1)(N(C)C(=O)c1cccc(F)c1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C28H31FN2O/c1-30(2)27(23-12-6-4-7-13-23)17-19-28(20-18-27,24-14-8-5-9-15-24)31(3)26(32)22-11-10-16-25(29)21-22/h4-16,21H,17-20H2,1-3H3
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GRUENENTHAL GMBH

US Patent


Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239875
PNG
(US9403767, 31 | US9403767, 32)
Show SMILES CCNC(=O)N(C)C1(CCC(CC1)(N(C)C)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H33N3O/c1-5-25-22(28)27(4)24(21-14-10-7-11-15-21)18-16-23(17-19-24,26(2)3)20-12-8-6-9-13-20/h6-15H,5,16-19H2,1-4H3,(H,25,28)
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239882
PNG
(US9403767, 40 | US9403767, 41)
Show SMILES CN(C)C1(CCC(CC1)(N(C)C)c1ccccc1)c1cccs1
Show InChI InChI=1S/C20H28N2S/c1-21(2)19(17-9-6-5-7-10-17)12-14-20(15-13-19,22(3)4)18-11-8-16-23-18/h5-11,16H,12-15H2,1-4H3
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239907
PNG
(US9403767, 72 | US9403767, 73)
Show SMILES CN(C)C1(CCC(CC1)(N(C)C)c1ccc(cc1)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C23H29F3N2/c1-27(2)21(18-8-6-5-7-9-18)14-16-22(17-15-21,28(3)4)19-10-12-20(13-11-19)23(24,25)26/h5-13H,14-17H2,1-4H3
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239897
PNG
(US9403767, 60 | US9403767, 61)
Show SMILES CNC1(CCC(CC2CCCC2)(CC1)N(C)C)c1ccccc1
Show InChI InChI=1S/C21H34N2/c1-22-21(19-11-5-4-6-12-19)15-13-20(14-16-21,23(2)3)17-18-9-7-8-10-18/h4-6,11-12,18,22H,7-10,13-17H2,1-3H3
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239925
PNG
(US9403767, 104 | US9403767, 105)
Show SMILES COc1ccc(cc1)C(=O)N(C)C1(CCC(CC1)(N(C)C)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C29H34N2O2/c1-30(2)28(24-11-7-5-8-12-24)19-21-29(22-20-28,25-13-9-6-10-14-25)31(3)27(32)23-15-17-26(33-4)18-16-23/h5-18H,19-22H2,1-4H3
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239895
PNG
(US9403767, 58 | US9403767, 59)
Show SMILES CCCCC1(CCC(CC1)(N(C)C)c1ccccc1)N(C)C
Show InChI InChI=1S/C20H34N2/c1-6-7-13-19(21(2)3)14-16-20(17-15-19,22(4)5)18-11-9-8-10-12-18/h8-12H,6-7,13-17H2,1-5H3
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239901
PNG
(US9403767, 64 | US9403767, 65)
Show SMILES CN(C)C1(CC2CCCC2)CCC(CC1)(N(C)C(=O)\C=C\c1ccccc1)c1ccccc1
Show InChI InChI=1S/C30H40N2O/c1-31(2)29(24-26-14-10-11-15-26)20-22-30(23-21-29,27-16-8-5-9-17-27)32(3)28(33)19-18-25-12-6-4-7-13-25/h4-9,12-13,16-19,26H,10-11,14-15,20-24H2,1-3H3/b19-18+
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239935
PNG
(US9403767, 119)
Show SMILES CN(C)C1(CCC(CC1)(N(C)Cc1cccc(F)c1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C28H33FN2/c1-30(2)27(24-12-6-4-7-13-24)17-19-28(20-18-27,25-14-8-5-9-15-25)31(3)22-23-11-10-16-26(29)21-23/h4-16,21H,17-20,22H2,1-3H3
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239892
PNG
(US9403767, 50 | US9403767, 51)
Show SMILES CN(C)C1(CCC(CC1)(N(C)Cc1ccccc1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C28H34N2/c1-29(2)27(25-15-9-5-10-16-25)19-21-28(22-20-27,26-17-11-6-12-18-26)30(3)23-24-13-7-4-8-14-24/h4-18H,19-23H2,1-3H3
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239918
PNG
(US9403767, 92 | US9403767, 93)
Show SMILES CN(C)C1(CCC(CC1)(N(C)C(=O)c1ccn(C)n1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C26H32N4O/c1-28(2)25(21-11-7-5-8-12-21)16-18-26(19-17-25,22-13-9-6-10-14-22)30(4)24(31)23-15-20-29(3)27-23/h5-15,20H,16-19H2,1-4H3
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239899
PNG
(US9403767, 62)
Show SMILES CN(C)C1(CC2CCCC2)CCC(CC1)(N(C)C)c1ccccc1
Show InChI InChI=1S/C22H36N2/c1-23(2)21(18-19-10-8-9-11-19)14-16-22(17-15-21,24(3)4)20-12-6-5-7-13-20/h5-7,12-13,19H,8-11,14-18H2,1-4H3
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239866
PNG
(US9403767, 19)
Show SMILES CCCCC1(CNS(=O)(=O)c2ccc(Cl)cc2)CCC(CC1)(N(C)C)c1ccccc1
Show InChI InChI=1S/C25H35ClN2O2S/c1-4-5-15-24(20-27-31(29,30)23-13-11-22(26)12-14-23)16-18-25(19-17-24,28(2)3)21-9-7-6-8-10-21/h6-14,27H,4-5,15-20H2,1-3H3
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239887
PNG
(US9403767, 45)
Show SMILES CN(C)C1(CCC(C)(CNS(=O)(=O)\C=C\c2ccccc2)CC1)c1cccc(F)c1
Show InChI InChI=1S/C24H31FN2O2S/c1-23(19-26-30(28,29)17-12-20-8-5-4-6-9-20)13-15-24(16-14-23,27(2)3)21-10-7-11-22(25)18-21/h4-12,17-18,26H,13-16,19H2,1-3H3/b17-12+
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US Patent


Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239858
PNG
(US9403767, 6)
Show SMILES CN(C)C1(CCC(CC1)(N1CCCC1)C(=N)c1cc2ccccc2n1C)c1ccccc1
Show InChI InChI=1S/C28H36N4/c1-30(2)27(23-12-5-4-6-13-23)15-17-28(18-16-27,32-19-9-10-20-32)26(29)25-21-22-11-7-8-14-24(22)31(25)3/h4-8,11-14,21,29H,9-10,15-20H2,1-3H3
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239875
PNG
(US9403767, 31 | US9403767, 32)
Show SMILES CCNC(=O)N(C)C1(CCC(CC1)(N(C)C)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H33N3O/c1-5-25-22(28)27(4)24(21-14-10-7-11-15-21)18-16-23(17-19-24,26(2)3)20-12-8-6-9-13-20/h6-15H,5,16-19H2,1-4H3,(H,25,28)
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239875
PNG
(US9403767, 31 | US9403767, 32)
Show SMILES CCNC(=O)N(C)C1(CCC(CC1)(N(C)C)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H33N3O/c1-5-25-22(28)27(4)24(21-14-10-7-11-15-21)18-16-23(17-19-24,26(2)3)20-12-8-6-9-13-20/h6-15H,5,16-19H2,1-4H3,(H,25,28)
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239881
PNG
(US9403767, 39)
Show SMILES CNC1(CCC(CC1)(N(C)C)c1cccs1)c1ccccc1
Show InChI InChI=1S/C19H26N2S/c1-20-18(16-8-5-4-6-9-16)11-13-19(14-12-18,21(2)3)17-10-7-15-22-17/h4-10,15,20H,11-14H2,1-3H3
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239909
PNG
(US9403767, 74 | US9403767, 75)
Show SMILES COc1ccc(cc1)C1(CCC(CC1)(N(C)C)c1ccccc1)N(C)C
Show InChI InChI=1S/C23H32N2O/c1-24(2)22(19-9-7-6-8-10-19)15-17-23(18-16-22,25(3)4)20-11-13-21(26-5)14-12-20/h6-14H,15-18H2,1-5H3
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239890
PNG
(US9403767, 48 | US9403767, 49)
Show SMILES CCCCN(C)C1(CCC(CC1)(N(C)C)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H36N2/c1-5-6-21-27(4)25(23-15-11-8-12-16-23)19-17-24(18-20-25,26(2)3)22-13-9-7-10-14-22/h7-16H,5-6,17-21H2,1-4H3
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239869
PNG
(US9403767, 24 | US9403767, 27)
Show SMILES CN(C)C1(CCC(CC1)(N(C)C(=O)\C=C\c1ccccc1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C30H34N2O/c1-31(2)29(26-15-9-5-10-16-26)21-23-30(24-22-29,27-17-11-6-12-18-27)32(3)28(33)20-19-25-13-7-4-8-14-25/h4-20H,21-24H2,1-3H3/b20-19+
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239923
PNG
(US9403767, 101 | US9403767, 102)
Show SMILES CN(C)C1(CCC(CC1)(N(C)Cc1ccn(C)n1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C26H34N4/c1-28(2)25(22-11-7-5-8-12-22)16-18-26(19-17-25,23-13-9-6-10-14-23)29(3)21-24-15-20-30(4)27-24/h5-15,20H,16-19,21H2,1-4H3
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239857
PNG
(US9403767, 5)
Show SMILES CN(C)C1(CCC(CC1)(N(C)C)c1ccccc1)C(=O)c1cc2ccccc2n1C
Show InChI InChI=1S/C26H33N3O/c1-27(2)25(21-12-7-6-8-13-21)15-17-26(18-16-25,28(3)4)24(30)23-19-20-11-9-10-14-22(20)29(23)5/h6-14,19H,15-18H2,1-5H3
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US Patent


Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239886
PNG
(US9403767, 44)
Show SMILES CN(C)C1(CCC(C)(CNS(=O)(=O)\C=C\c2ccccc2)CC1)c1cccc(F)c1
Show InChI InChI=1S/C24H31FN2O2S/c1-23(19-26-30(28,29)17-12-20-8-5-4-6-9-20)13-15-24(16-14-23,27(2)3)21-10-7-11-22(25)18-21/h4-12,17-18,26H,13-16,19H2,1-3H3/b17-12+
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77.5n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239862
PNG
(US9403767, 12 | US9403767, 13)
Show SMILES CN(C)C1(Cc2ccccc2)CCC(CC1)(N(C)C)c1ccccc1
Show InChI InChI=1S/C23H32N2/c1-24(2)22(19-20-11-7-5-8-12-20)15-17-23(18-16-22,25(3)4)21-13-9-6-10-14-21/h5-14H,15-19H2,1-4H3
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80.5n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239900
PNG
(US9403767, 63)
Show SMILES CN(C)C1(CC2CCCC2)CCC(CC1)(N(C)C)c1ccccc1
Show InChI InChI=1S/C22H36N2/c1-23(2)21(18-19-10-8-9-11-19)14-16-22(17-15-21,24(3)4)20-12-6-5-7-13-20/h5-7,12-13,19H,8-11,14-18H2,1-4H3
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87n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239899
PNG
(US9403767, 62)
Show SMILES CN(C)C1(CC2CCCC2)CCC(CC1)(N(C)C)c1ccccc1
Show InChI InChI=1S/C22H36N2/c1-23(2)21(18-19-10-8-9-11-19)14-16-22(17-15-21,24(3)4)20-12-6-5-7-13-20/h5-7,12-13,19H,8-11,14-18H2,1-4H3
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89.5n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239873
PNG
(US9403767, 29 | US9403767, 30)
Show SMILES CN(C)C1(CCC(CC1)(N(C)C(=O)NCc1ccccc1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C29H35N3O/c1-31(2)28(25-15-9-5-10-16-25)19-21-29(22-20-28,26-17-11-6-12-18-26)32(3)27(33)30-23-24-13-7-4-8-14-24/h4-18H,19-23H2,1-3H3,(H,30,33)
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90n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239901
PNG
(US9403767, 64 | US9403767, 65)
Show SMILES CN(C)C1(CC2CCCC2)CCC(CC1)(N(C)C(=O)\C=C\c1ccccc1)c1ccccc1
Show InChI InChI=1S/C30H40N2O/c1-31(2)29(24-26-14-10-11-15-26)20-22-30(23-21-29,27-16-8-5-9-17-27)32(3)28(33)19-18-25-12-6-4-7-13-25/h4-9,12-13,16-19,26H,10-11,14-15,20-24H2,1-3H3/b19-18+
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92.5n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239875
PNG
(US9403767, 31 | US9403767, 32)
Show SMILES CCNC(=O)N(C)C1(CCC(CC1)(N(C)C)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H33N3O/c1-5-25-22(28)27(4)24(21-14-10-7-11-15-21)18-16-23(17-19-24,26(2)3)20-12-8-6-9-13-20/h6-15H,5,16-19H2,1-4H3,(H,25,28)
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95.5n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239880
PNG
(US9403767, 37)
Show SMILES CN(C)CC1(CCC(CC1)(N(C)C)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H32N2/c1-24(2)19-22(20-11-7-5-8-12-20)15-17-23(18-16-22,25(3)4)21-13-9-6-10-14-21/h5-14H,15-19H2,1-4H3
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103n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239892
PNG
(US9403767, 50 | US9403767, 51)
Show SMILES CN(C)C1(CCC(CC1)(N(C)Cc1ccccc1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C28H34N2/c1-29(2)27(25-15-9-5-10-16-25)19-21-28(22-20-27,26-17-11-6-12-18-26)30(3)23-24-13-7-4-8-14-24/h4-18H,19-23H2,1-3H3
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GRUENENTHAL GMBH

US Patent


Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239897
PNG
(US9403767, 60 | US9403767, 61)
Show SMILES CNC1(CCC(CC2CCCC2)(CC1)N(C)C)c1ccccc1
Show InChI InChI=1S/C21H34N2/c1-22-21(19-11-5-4-6-12-19)15-13-20(14-16-21,23(2)3)17-18-9-7-8-10-18/h4-6,11-12,18,22H,7-10,13-17H2,1-3H3
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107n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239920
PNG
(US9403767, 96)
Show SMILES CCCC(=O)OC1(CCC(CC1)(N(C)C)c1cccc(F)c1)c1[nH]c2ccccc2c1C
Show InChI InChI=1S/C27H33FN2O2/c1-5-9-24(31)32-27(25-19(2)22-12-6-7-13-23(22)29-25)16-14-26(15-17-27,30(3)4)20-10-8-11-21(28)18-20/h6-8,10-13,18,29H,5,9,14-17H2,1-4H3
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108n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239895
PNG
(US9403767, 58 | US9403767, 59)
Show SMILES CCCCC1(CCC(CC1)(N(C)C)c1ccccc1)N(C)C
Show InChI InChI=1S/C20H34N2/c1-6-7-13-19(21(2)3)14-16-20(17-15-19,22(4)5)18-11-9-8-10-12-18/h8-12H,6-7,13-17H2,1-5H3
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115n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239907
PNG
(US9403767, 72 | US9403767, 73)
Show SMILES CN(C)C1(CCC(CC1)(N(C)C)c1ccc(cc1)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C23H29F3N2/c1-27(2)21(18-8-6-5-7-9-18)14-16-22(17-15-21,28(3)4)19-10-12-20(13-11-19)23(24,25)26/h5-13H,14-17H2,1-4H3
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115n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239914
PNG
(US9403767, 85)
Show SMILES CN(C)C1(CCC(CC1)(N(C)Cc1cccnc1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C27H33N3/c1-29(2)26(24-12-6-4-7-13-24)16-18-27(19-17-26,25-14-8-5-9-15-25)30(3)22-23-11-10-20-28-21-23/h4-15,20-21H,16-19,22H2,1-3H3
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115n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239892
PNG
(US9403767, 50 | US9403767, 51)
Show SMILES CN(C)C1(CCC(CC1)(N(C)Cc1ccccc1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C28H34N2/c1-29(2)27(25-15-9-5-10-16-25)19-21-28(22-20-27,26-17-11-6-12-18-26)30(3)23-24-13-7-4-8-14-24/h4-18H,19-23H2,1-3H3
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120n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239931
PNG
(US9403767, 114)
Show SMILES CN(C)C1(CCC(CC1)(N(C)Cc1cccc(c1)C(F)(F)F)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C29H33F3N2/c1-33(2)27(24-12-6-4-7-13-24)17-19-28(20-18-27,25-14-8-5-9-15-25)34(3)22-23-11-10-16-26(21-23)29(30,31)32/h4-16,21H,17-20,22H2,1-3H3
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130n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239885
PNG
(US9403767, 43)
Show InChI InChI=1S/C25H31FN2O/c1-19(27-24(29)13-12-20-8-5-4-6-9-20)21-14-16-25(17-15-21,28(2)3)22-10-7-11-23(26)18-22/h4-13,18-19,21H,14-17H2,1-3H3,(H,27,29)/b13-12+
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131n/an/an/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239864
PNG
(US9403767, 17)
Show SMILES CN(C)C1(CCC(C)(CNC(C)=O)CC1)c1ccccc1
Show InChI InChI=1S/C18H28N2O/c1-15(21)19-14-17(2)10-12-18(13-11-17,20(3)4)16-8-6-5-7-9-16/h5-9H,10-14H2,1-4H3,(H,19,21)
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US Patent


Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239929
PNG
(US9403767, 110)
Show SMILES CNC1(CCC(CC1)(N(C)C)c1cccc(F)c1)c1[nH]c2ccccc2c1C
Show InChI InChI=1S/C24H30FN3/c1-17-20-10-5-6-11-21(20)27-22(17)23(26-2)12-14-24(15-13-23,28(3)4)18-8-7-9-19(25)16-18/h5-11,16,26-27H,12-15H2,1-4H3
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155n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239862
PNG
(US9403767, 12 | US9403767, 13)
Show SMILES CN(C)C1(Cc2ccccc2)CCC(CC1)(N(C)C)c1ccccc1
Show InChI InChI=1S/C23H32N2/c1-24(2)22(19-20-11-7-5-8-12-20)15-17-23(18-16-22,25(3)4)21-13-9-6-10-14-21/h5-14H,15-19H2,1-4H3
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239907
PNG
(US9403767, 72 | US9403767, 73)
Show SMILES CN(C)C1(CCC(CC1)(N(C)C)c1ccc(cc1)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C23H29F3N2/c1-27(2)21(18-8-6-5-7-9-18)14-16-22(17-15-21,28(3)4)19-10-12-20(13-11-19)23(24,25)26/h5-13H,14-17H2,1-4H3
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165n/an/an/an/an/an/an/an/a



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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239895
PNG
(US9403767, 58 | US9403767, 59)
Show SMILES CCCCC1(CCC(CC1)(N(C)C)c1ccccc1)N(C)C
Show InChI InChI=1S/C20H34N2/c1-6-7-13-19(21(2)3)14-16-20(17-15-19,22(4)5)18-11-9-8-10-12-18/h8-12H,6-7,13-17H2,1-5H3
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239938
PNG
(US9403767, 122)
Show SMILES CNC(=O)CN(C)C1(CCC(CC1)(N(C)C)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H33N3O/c1-25-22(28)19-27(4)24(21-13-9-6-10-14-21)17-15-23(16-18-24,26(2)3)20-11-7-5-8-12-20/h5-14H,15-19H2,1-4H3,(H,25,28)
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


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More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239858
PNG
(US9403767, 6)
Show SMILES CN(C)C1(CCC(CC1)(N1CCCC1)C(=N)c1cc2ccccc2n1C)c1ccccc1
Show InChI InChI=1S/C28H36N4/c1-30(2)27(23-12-5-4-6-13-23)15-17-28(18-16-27,32-19-9-10-20-32)26(29)25-21-22-11-7-8-14-24(22)31(25)3/h4-8,11-14,21,29H,9-10,15-20H2,1-3H3
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239911
PNG
(US9403767, 76 | US9403767, 77)
Show SMILES CN(CC1(C)CCC(CC1)(N(C)C)c1ccccc1)c1c[nH]c2ccccc12
Show InChI InChI=1S/C25H33N3/c1-24(19-28(4)23-18-26-22-13-9-8-12-21(22)23)14-16-25(17-15-24,27(2)3)20-10-6-5-7-11-20/h5-13,18,26H,14-17,19H2,1-4H3
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239888
PNG
(US9403767, 46 | US9403767, 47)
Show SMILES CCCCC1(CCC(CC1)(NC)c1ccccc1)N(C)C
Show InChI InChI=1S/C19H32N2/c1-5-6-12-18(21(3)4)13-15-19(20-2,16-14-18)17-10-8-7-9-11-17/h7-11,20H,5-6,12-16H2,1-4H3
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239945
PNG
(US9403767, 132)
Show SMILES CN(C)C1(CCC(CC1)(N1CCCC1)c1[nH]c2ccc(F)cc2c1C)c1ccccc1
Show InChI InChI=1S/C27H34FN3/c1-20-23-19-22(28)11-12-24(23)29-25(20)27(31-17-7-8-18-31)15-13-26(14-16-27,30(2)3)21-9-5-4-6-10-21/h4-6,9-12,19,29H,7-8,13-18H2,1-3H3
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239870
PNG
(US9403767, 25 | US9403767, 28)
Show SMILES CN(C)C1(CCC(CC1)(N(C)C(C)=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H30N2O/c1-19(26)25(4)23(21-13-9-6-10-14-21)17-15-22(16-18-23,24(2)3)20-11-7-5-8-12-20/h5-14H,15-18H2,1-4H3
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239905
PNG
(US9403767, 69)
Show SMILES CNC1(CCC(CC1)(N(C)C)c1ccc(OC)cc1)c1ccccc1
Show InChI InChI=1S/C22H30N2O/c1-23-21(18-8-6-5-7-9-18)14-16-22(17-15-21,24(2)3)19-10-12-20(25-4)13-11-19/h5-13,23H,14-17H2,1-4H3
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239922
PNG
(US9403767, 100)
Show SMILES COc1ccc(Oc2nc(Oc3ccc(OC)cc3)nc(n2)N(C)C2(CCC(CC2)(N(C)C)c2ccccc2)c2ccccc2)cc1
Show InChI InChI=1S/C38H41N5O4/c1-42(2)37(28-12-8-6-9-13-28)24-26-38(27-25-37,29-14-10-7-11-15-29)43(3)34-39-35(46-32-20-16-30(44-4)17-21-32)41-36(40-34)47-33-22-18-31(45-5)19-23-33/h6-23H,24-27H2,1-5H3
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The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239878
PNG
(US9403767, 34)
Show SMILES CN(C)CC1(Cc2ccccc2)CCC(CC1)(N(C)C)c1ccccc1
Show InChI InChI=1S/C24H34N2/c1-25(2)20-23(19-21-11-7-5-8-12-21)15-17-24(18-16-23,26(3)4)22-13-9-6-10-14-22/h5-14H,15-20H2,1-4H3
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The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239937
PNG
(US9403767, 121 | US9403767, 123)
Show SMILES CN(C)C(=O)CN(C)C1(CCC(CC1)(N(C)C)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H35N3O/c1-26(2)23(29)20-28(5)25(22-14-10-7-11-15-22)18-16-24(17-19-25,27(3)4)21-12-8-6-9-13-21/h6-15H,16-20H2,1-5H3
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The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239920
PNG
(US9403767, 96)
Show SMILES CCCC(=O)OC1(CCC(CC1)(N(C)C)c1cccc(F)c1)c1[nH]c2ccccc2c1C
Show InChI InChI=1S/C27H33FN2O2/c1-5-9-24(31)32-27(25-19(2)22-12-6-7-13-23(22)29-25)16-14-26(15-17-27,30(3)4)20-10-8-11-21(28)18-20/h6-8,10-13,18,29H,5,9,14-17H2,1-4H3
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The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239918
PNG
(US9403767, 92 | US9403767, 93)
Show SMILES CN(C)C1(CCC(CC1)(N(C)C(=O)c1ccn(C)n1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C26H32N4O/c1-28(2)25(21-11-7-5-8-12-21)16-18-26(19-17-25,22-13-9-6-10-14-22)30(4)24(31)23-15-20-29(3)27-23/h5-15,20H,16-19H2,1-4H3
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239941
PNG
(US9403767, 125)
Show SMILES CN(C)C1(CCC(CC1)(N(C)C)c1ccccc1)c1[nH]c2ccc(F)cc2c1C
Show InChI InChI=1S/C25H32FN3/c1-18-21-17-20(26)11-12-22(21)27-23(18)25(29(4)5)15-13-24(14-16-25,28(2)3)19-9-7-6-8-10-19/h6-12,17,27H,13-16H2,1-5H3
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The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239942
PNG
(US9403767, 128)
Show SMILES CN(C)c1nc(nc(n1)N(C)C1(CCC(CC1)(N(C)C)c1ccccc1)c1ccccc1)N(C)C
Show InChI InChI=1S/C28H39N7/c1-32(2)24-29-25(33(3)4)31-26(30-24)35(7)28(23-16-12-9-13-17-23)20-18-27(19-21-28,34(5)6)22-14-10-8-11-15-22/h8-17H,18-21H2,1-7H3
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The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239911
PNG
(US9403767, 76 | US9403767, 77)
Show SMILES CN(CC1(C)CCC(CC1)(N(C)C)c1ccccc1)c1c[nH]c2ccccc12
Show InChI InChI=1S/C25H33N3/c1-24(19-28(4)23-18-26-22-13-9-8-12-21(22)23)14-16-25(17-15-24,27(2)3)20-10-6-5-7-11-20/h5-13,18,26H,14-17,19H2,1-4H3
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239915
PNG
(US9403767, 89)
Show SMILES CN(C)C1(CCC(CC1)(N(C)Cc1cccnc1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C27H33N3/c1-29(2)26(24-12-6-4-7-13-24)16-18-27(19-17-26,25-14-8-5-9-15-25)30(3)22-23-11-10-20-28-21-23/h4-15,20-21H,16-19,22H2,1-3H3
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239906
PNG
(US9403767, 71)
Show SMILES CNC1(CCC(CC1)(N(C)C)c1ccc(cc1)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C22H27F3N2/c1-26-20(17-7-5-4-6-8-17)13-15-21(16-14-20,27(2)3)18-9-11-19(12-10-18)22(23,24)25/h4-12,26H,13-16H2,1-3H3
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239862
PNG
(US9403767, 12 | US9403767, 13)
Show SMILES CN(C)C1(Cc2ccccc2)CCC(CC1)(N(C)C)c1ccccc1
Show InChI InChI=1S/C23H32N2/c1-24(2)22(19-20-11-7-5-8-12-20)15-17-23(18-16-22,25(3)4)21-13-9-6-10-14-21/h5-14H,15-19H2,1-4H3
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The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239897
PNG
(US9403767, 60 | US9403767, 61)
Show SMILES CNC1(CCC(CC2CCCC2)(CC1)N(C)C)c1ccccc1
Show InChI InChI=1S/C21H34N2/c1-22-21(19-11-5-4-6-12-19)15-13-20(14-16-21,23(2)3)17-18-9-7-8-10-18/h4-6,11-12,18,22H,7-10,13-17H2,1-3H3
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The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239913
PNG
(US9403767, 78)
Show SMILES CN(Cc1c[nH]c2ccccc12)CC1(C)CCC(CC1)(N(C)C)c1ccccc1
Show InChI InChI=1S/C26H35N3/c1-25(20-29(4)19-21-18-27-24-13-9-8-12-23(21)24)14-16-26(17-15-25,28(2)3)22-10-6-5-7-11-22/h5-13,18,27H,14-17,19-20H2,1-4H3
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239879
PNG
(US9403767, 35)
Show SMILES CN(C)C1(CCC(CC1)(N(C)C)c1ccccc1)c1[nH]c2ccccc2c1C
Show InChI InChI=1S/C25H33N3/c1-19-21-13-9-10-14-22(21)26-23(19)25(28(4)5)17-15-24(16-18-25,27(2)3)20-11-7-6-8-12-20/h6-14,26H,15-18H2,1-5H3
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239943
PNG
(US9403767, 130)
Show SMILES CN(C)C1(CCC(CC1)(N(C)CCCCO)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H36N2O/c1-26(2)24(22-12-6-4-7-13-22)16-18-25(19-17-24,23-14-8-5-9-15-23)27(3)20-10-11-21-28/h4-9,12-15,28H,10-11,16-21H2,1-3H3
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239930
PNG
(US9403767, 111)
Show SMILES CN(C)C1(CCC(CC1)(N1CCCCC1)c1[nH]c2ccccc2c1C)c1ccccc1
Show InChI InChI=1S/C28H37N3/c1-22-24-14-8-9-15-25(24)29-26(22)28(31-20-10-5-11-21-31)18-16-27(17-19-28,30(2)3)23-12-6-4-7-13-23/h4,6-9,12-15,29H,5,10-11,16-21H2,1-3H3
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The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239895
PNG
(US9403767, 58 | US9403767, 59)
Show SMILES CCCCC1(CCC(CC1)(N(C)C)c1ccccc1)N(C)C
Show InChI InChI=1S/C20H34N2/c1-6-7-13-19(21(2)3)14-16-20(17-15-19,22(4)5)18-11-9-8-10-12-18/h8-12H,6-7,13-17H2,1-5H3
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239901
PNG
(US9403767, 64 | US9403767, 65)
Show SMILES CN(C)C1(CC2CCCC2)CCC(CC1)(N(C)C(=O)\C=C\c1ccccc1)c1ccccc1
Show InChI InChI=1S/C30H40N2O/c1-31(2)29(24-26-14-10-11-15-26)20-22-30(23-21-29,27-16-8-5-9-17-27)32(3)28(33)19-18-25-12-6-4-7-13-25/h4-9,12-13,16-19,26H,10-11,14-15,20-24H2,1-3H3/b19-18+
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US Patent


Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239927
PNG
(US9403767, 106)
Show SMILES COc1ccc(CN(C)C2(CCC(CC2)(N(C)C)c2ccccc2)c2ccccc2)cc1
Show InChI InChI=1S/C29H36N2O/c1-30(2)28(25-11-7-5-8-12-25)19-21-29(22-20-28,26-13-9-6-10-14-26)31(3)23-24-15-17-27(32-4)18-16-24/h5-18H,19-23H2,1-4H3
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US Patent


Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239882
PNG
(US9403767, 40 | US9403767, 41)
Show SMILES CN(C)C1(CCC(CC1)(N(C)C)c1ccccc1)c1cccs1
Show InChI InChI=1S/C20H28N2S/c1-21(2)19(17-9-6-5-7-10-17)12-14-20(15-13-19,22(3)4)18-11-8-16-23-18/h5-11,16H,12-15H2,1-4H3
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239936
PNG
(US9403767, 120)
Show SMILES CN(C)C1(CCC(CC1)(N(C)CCO)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H32N2O/c1-24(2)22(20-10-6-4-7-11-20)14-16-23(17-15-22,25(3)18-19-26)21-12-8-5-9-13-21/h4-13,26H,14-19H2,1-3H3
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239867
PNG
(US9403767, 20 | US9403767, 21)
Show SMILES CN(C)C1(CCC(CO)(CCCCc2ccccc2)CC1)c1ccccc1
Show InChI InChI=1S/C25H35NO/c1-26(2)25(23-14-7-4-8-15-23)19-17-24(21-27,18-20-25)16-10-9-13-22-11-5-3-6-12-22/h3-8,11-12,14-15,27H,9-10,13,16-21H2,1-2H3
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239916
PNG
(US9403767, 90)
Show SMILES CNc1nc(NC)nc(n1)N(C)C1(CCC(CC1)(N(C)C)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C26H35N7/c1-27-22-29-23(28-2)31-24(30-22)33(5)26(21-14-10-7-11-15-21)18-16-25(17-19-26,32(3)4)20-12-8-6-9-13-20/h6-15H,16-19H2,1-5H3,(H2,27,28,29,30,31)
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239897
PNG
(US9403767, 60 | US9403767, 61)
Show SMILES CNC1(CCC(CC2CCCC2)(CC1)N(C)C)c1ccccc1
Show InChI InChI=1S/C21H34N2/c1-22-21(19-11-5-4-6-12-19)15-13-20(14-16-21,23(2)3)17-18-9-7-8-10-18/h4-6,11-12,18,22H,7-10,13-17H2,1-3H3
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239881
PNG
(US9403767, 39)
Show SMILES CNC1(CCC(CC1)(N(C)C)c1cccs1)c1ccccc1
Show InChI InChI=1S/C19H26N2S/c1-20-18(16-8-5-4-6-9-16)11-13-19(14-12-18,21(2)3)17-10-7-15-22-17/h4-10,15,20H,11-14H2,1-3H3
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239861
PNG
(US9403767, 11)
Show SMILES CN(C)C1(CCC(CC1)(N(C)C)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C22H30N2/c1-23(2)21(19-11-7-5-8-12-19)15-17-22(18-16-21,24(3)4)20-13-9-6-10-14-20/h5-14H,15-18H2,1-4H3
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239929
PNG
(US9403767, 110)
Show SMILES CNC1(CCC(CC1)(N(C)C)c1cccc(F)c1)c1[nH]c2ccccc2c1C
Show InChI InChI=1S/C24H30FN3/c1-17-20-10-5-6-11-21(20)27-22(17)23(26-2)12-14-24(15-13-23,28(3)4)18-8-7-9-19(25)16-18/h5-11,16,26-27H,12-15H2,1-4H3
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239857
PNG
(US9403767, 5)
Show SMILES CN(C)C1(CCC(CC1)(N(C)C)c1ccccc1)C(=O)c1cc2ccccc2n1C
Show InChI InChI=1S/C26H33N3O/c1-27(2)25(21-12-7-6-8-13-21)15-17-26(18-16-25,28(3)4)24(30)23-19-20-11-9-10-14-22(20)29(23)5/h6-14,19H,15-18H2,1-5H3
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239860
PNG
(US9403767, 9)
Show SMILES CNC1(CCC(CC1)(N(C)C)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C21H28N2/c1-22-20(18-10-6-4-7-11-18)14-16-21(17-15-20,23(2)3)19-12-8-5-9-13-19/h4-13,22H,14-17H2,1-3H3
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239905
PNG
(US9403767, 69)
Show SMILES CNC1(CCC(CC1)(N(C)C)c1ccc(OC)cc1)c1ccccc1
Show InChI InChI=1S/C22H30N2O/c1-23-21(18-8-6-5-7-9-18)14-16-22(17-15-21,24(2)3)19-10-12-20(25-4)13-11-19/h5-13,23H,14-17H2,1-4H3
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239909
PNG
(US9403767, 74 | US9403767, 75)
Show SMILES COc1ccc(cc1)C1(CCC(CC1)(N(C)C)c1ccccc1)N(C)C
Show InChI InChI=1S/C23H32N2O/c1-24(2)22(19-9-7-6-8-10-19)15-17-23(18-16-22,25(3)4)20-11-13-21(26-5)14-12-20/h6-14H,15-18H2,1-5H3
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239909
PNG
(US9403767, 74 | US9403767, 75)
Show SMILES COc1ccc(cc1)C1(CCC(CC1)(N(C)C)c1ccccc1)N(C)C
Show InChI InChI=1S/C23H32N2O/c1-24(2)22(19-9-7-6-8-10-19)15-17-23(18-16-22,25(3)4)20-11-13-21(26-5)14-12-20/h6-14H,15-18H2,1-5H3
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239888
PNG
(US9403767, 46 | US9403767, 47)
Show SMILES CCCCC1(CCC(CC1)(NC)c1ccccc1)N(C)C
Show InChI InChI=1S/C19H32N2/c1-5-6-12-18(21(3)4)13-15-19(20-2,16-14-18)17-10-8-7-9-11-17/h7-11,20H,5-6,12-16H2,1-4H3
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239913
PNG
(US9403767, 78)
Show SMILES CN(Cc1c[nH]c2ccccc12)CC1(C)CCC(CC1)(N(C)C)c1ccccc1
Show InChI InChI=1S/C26H35N3/c1-25(20-29(4)19-21-18-27-24-13-9-8-12-23(21)24)14-16-26(17-15-25,28(2)3)22-10-6-5-7-11-22/h5-13,18,27H,14-17,19-20H2,1-4H3
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239940
PNG
(US9403767, 124)
Show SMILES CNC(=O)CN(C)C1(CCC(CC1)(N(C)C)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H33N3O/c1-25-22(28)19-27(4)24(21-13-9-6-10-14-21)17-15-23(16-18-24,26(2)3)20-11-7-5-8-12-20/h5-14H,15-19H2,1-4H3,(H,25,28)
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239917
PNG
(US9403767, 91)
Show SMILES CNc1nc(Oc2ccc(OC)cc2)nc(n1)N(C)C1(CCC(CC1)(N(C)C)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C32H38N6O2/c1-33-28-34-29(36-30(35-28)40-27-18-16-26(39-5)17-19-27)38(4)32(25-14-10-7-11-15-25)22-20-31(21-23-32,37(2)3)24-12-8-6-9-13-24/h6-19H,20-23H2,1-5H3,(H,33,34,35,36)
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239888
PNG
(US9403767, 46 | US9403767, 47)
Show SMILES CCCCC1(CCC(CC1)(NC)c1ccccc1)N(C)C
Show InChI InChI=1S/C19H32N2/c1-5-6-12-18(21(3)4)13-15-19(20-2,16-14-18)17-10-8-7-9-11-17/h7-11,20H,5-6,12-16H2,1-4H3
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239885
PNG
(US9403767, 43)
Show InChI InChI=1S/C25H31FN2O/c1-19(27-24(29)13-12-20-8-5-4-6-9-20)21-14-16-25(17-15-21,28(2)3)22-10-7-11-23(26)18-22/h4-13,18-19,21H,14-17H2,1-3H3,(H,27,29)/b13-12+
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239867
PNG
(US9403767, 20 | US9403767, 21)
Show SMILES CN(C)C1(CCC(CO)(CCCCc2ccccc2)CC1)c1ccccc1
Show InChI InChI=1S/C25H35NO/c1-26(2)25(23-14-7-4-8-15-23)19-17-24(21-27,18-20-25)16-10-9-13-22-11-5-3-6-12-22/h3-8,11-12,14-15,27H,9-10,13,16-21H2,1-2H3
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239870
PNG
(US9403767, 25 | US9403767, 28)
Show SMILES CN(C)C1(CCC(CC1)(N(C)C(C)=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H30N2O/c1-19(26)25(4)23(21-13-9-6-10-14-21)17-15-22(16-18-23,24(2)3)20-11-7-5-8-12-20/h5-14H,15-18H2,1-4H3
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239890
PNG
(US9403767, 48 | US9403767, 49)
Show SMILES CCCCN(C)C1(CCC(CC1)(N(C)C)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H36N2/c1-5-6-21-27(4)25(23-15-11-8-12-16-23)19-17-24(18-20-25,26(2)3)22-13-9-7-10-14-22/h7-16H,5-6,17-21H2,1-4H3
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239942
PNG
(US9403767, 128)
Show SMILES CN(C)c1nc(nc(n1)N(C)C1(CCC(CC1)(N(C)C)c1ccccc1)c1ccccc1)N(C)C
Show InChI InChI=1S/C28H39N7/c1-32(2)24-29-25(33(3)4)31-26(30-24)35(7)28(23-16-12-9-13-17-23)20-18-27(19-21-28,34(5)6)22-14-10-8-11-15-22/h8-17H,18-21H2,1-7H3
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The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239856
PNG
(US9403767, 4)
Show SMILES CN(C)C1(CCC(CC1)(N(C)C)c1ccccc1)C(=O)c1cc2ccccc2n1C
Show InChI InChI=1S/C26H33N3O/c1-27(2)25(21-12-7-6-8-13-21)15-17-26(18-16-25,28(3)4)24(30)23-19-20-11-9-10-14-22(20)29(23)5/h6-14,19H,15-18H2,1-5H3
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239859
PNG
(US9403767, 7)
Show SMILES CN(C)C1(CCC(CC1)(N1CCCC1)C(=O)c1cc2ccccc2n1C)c1ccccc1
Show InChI InChI=1S/C28H35N3O/c1-29(2)27(23-12-5-4-6-13-23)15-17-28(18-16-27,31-19-9-10-20-31)26(32)25-21-22-11-7-8-14-24(22)30(25)3/h4-8,11-14,21H,9-10,15-20H2,1-3H3
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239879
PNG
(US9403767, 35)
Show SMILES CN(C)C1(CCC(CC1)(N(C)C)c1ccccc1)c1[nH]c2ccccc2c1C
Show InChI InChI=1S/C25H33N3/c1-19-21-13-9-10-14-22(21)26-23(19)25(28(4)5)17-15-24(16-18-25,27(2)3)20-11-7-6-8-12-20/h6-14,26H,15-18H2,1-5H3
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239947
PNG
(US9403767, C-2)
Show SMILES CN(C)C1(CCC(O)(CC1)c1ccccc1)c1ccc(C)cc1
Show InChI InChI=1S/C21H27NO/c1-17-9-11-18(12-10-17)20(22(2)3)13-15-21(23,16-14-20)19-7-5-4-6-8-19/h4-12,23H,13-16H2,1-3H3
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239870
PNG
(US9403767, 25 | US9403767, 28)
Show SMILES CN(C)C1(CCC(CC1)(N(C)C(C)=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H30N2O/c1-19(26)25(4)23(21-13-9-6-10-14-21)17-15-22(16-18-23,24(2)3)20-11-7-5-8-12-20/h5-14H,15-18H2,1-4H3
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239930
PNG
(US9403767, 111)
Show SMILES CN(C)C1(CCC(CC1)(N1CCCCC1)c1[nH]c2ccccc2c1C)c1ccccc1
Show InChI InChI=1S/C28H37N3/c1-22-24-14-8-9-15-25(24)29-26(22)28(31-20-10-5-11-21-31)18-16-27(17-19-28,30(2)3)23-12-6-4-7-13-23/h4,6-9,12-15,29H,5,10-11,16-21H2,1-3H3
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239916
PNG
(US9403767, 90)
Show SMILES CNc1nc(NC)nc(n1)N(C)C1(CCC(CC1)(N(C)C)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C26H35N7/c1-27-22-29-23(28-2)31-24(30-22)33(5)26(21-14-10-7-11-15-21)18-16-25(17-19-26,32(3)4)20-12-8-6-9-13-20/h6-15H,16-19H2,1-5H3,(H2,27,28,29,30,31)
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239915
PNG
(US9403767, 89)
Show SMILES CN(C)C1(CCC(CC1)(N(C)Cc1cccnc1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C27H33N3/c1-29(2)26(24-12-6-4-7-13-24)16-18-27(19-17-26,25-14-8-5-9-15-25)30(3)22-23-11-10-20-28-21-23/h4-15,20-21H,16-19,22H2,1-3H3
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239877
PNG
(US9403767, 33)
Show SMILES CNC1(CCC(CN(C)C)(Cc2ccccc2)CC1)c1ccccc1
Show InChI InChI=1S/C23H32N2/c1-24-23(21-12-8-5-9-13-21)16-14-22(15-17-23,19-25(2)3)18-20-10-6-4-7-11-20/h4-13,24H,14-19H2,1-3H3
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239859
PNG
(US9403767, 7)
Show SMILES CN(C)C1(CCC(CC1)(N1CCCC1)C(=O)c1cc2ccccc2n1C)c1ccccc1
Show InChI InChI=1S/C28H35N3O/c1-29(2)27(23-12-5-4-6-13-23)15-17-28(18-16-27,31-19-9-10-20-31)26(32)25-21-22-11-7-8-14-24(22)30(25)3/h4-8,11-14,21H,9-10,15-20H2,1-3H3
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM239861
PNG
(US9403767, 11)
Show SMILES CN(C)C1(CCC(CC1)(N(C)C)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C22H30N2/c1-23(2)21(19-11-7-5-8-12-19)15-17-22(18-16-21,24(3)4)20-13-9-6-10-14-20/h5-14H,15-18H2,1-4H3
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Assay Description
The determination occurred in a homogeneous batch in microtiter plates. For this, dilution series of the respective substances to be tested were incu...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239932
PNG
(US9403767, 115)
Show SMILES CN(C)C1(CCC(CC1)(N(C)Cc1cccc(c1)C(F)(F)F)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C29H33F3N2/c1-33(2)27(24-12-6-4-7-13-24)17-19-28(20-18-27,25-14-8-5-9-15-25)34(3)22-23-11-10-16-26(21-23)29(30,31)32/h4-16,21H,17-20,22H2,1-3H3
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM239860
PNG
(US9403767, 9)
Show SMILES CNC1(CCC(CC1)(N(C)C)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C21H28N2/c1-22-20(18-10-6-4-7-11-18)14-16-21(17-15-20,23(2)3)19-12-8-5-9-13-19/h4-13,22H,14-17H2,1-3H3
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Assay Description
The determination occurred in a homogeneous batch in microtiter plates. For this, dilution series of the respective substances to be tested were incu...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239864
PNG
(US9403767, 17)
Show SMILES CN(C)C1(CCC(C)(CNC(C)=O)CC1)c1ccccc1
Show InChI InChI=1S/C18H28N2O/c1-15(21)19-14-17(2)10-12-18(13-11-17,20(3)4)16-8-6-5-7-9-16/h5-9H,10-14H2,1-4H3,(H,19,21)
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239906
PNG
(US9403767, 71)
Show SMILES CNC1(CCC(CC1)(N(C)C)c1ccc(cc1)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C22H27F3N2/c1-26-20(17-7-5-4-6-8-17)13-15-21(16-14-20,27(2)3)18-9-11-19(12-10-18)22(23,24)25/h4-12,26H,13-16H2,1-3H3
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239890
PNG
(US9403767, 48 | US9403767, 49)
Show SMILES CCCCN(C)C1(CCC(CC1)(N(C)C)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H36N2/c1-5-6-21-27(4)25(23-15-11-8-12-16-23)19-17-24(18-20-25,26(2)3)22-13-9-7-10-14-22/h7-16H,5-6,17-21H2,1-4H3
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239862
PNG
(US9403767, 12 | US9403767, 13)
Show SMILES CN(C)C1(Cc2ccccc2)CCC(CC1)(N(C)C)c1ccccc1
Show InChI InChI=1S/C23H32N2/c1-24(2)22(19-20-11-7-5-8-12-20)15-17-23(18-16-22,25(3)4)21-13-9-6-10-14-21/h5-14H,15-19H2,1-4H3
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239884
PNG
(US9403767, 42)
Show SMILES CN(C)C1(CCC(C)(CNC(=O)\C=C\c2ccccc2)CC1)c1cccc(F)c1
Show InChI InChI=1S/C25H31FN2O/c1-24(19-27-23(29)13-12-20-8-5-4-6-9-20)14-16-25(17-15-24,28(2)3)21-10-7-11-22(26)18-21/h4-13,18H,14-17,19H2,1-3H3,(H,27,29)/b13-12+
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239937
PNG
(US9403767, 121 | US9403767, 123)
Show SMILES CN(C)C(=O)CN(C)C1(CCC(CC1)(N(C)C)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H35N3O/c1-26(2)23(29)20-28(5)25(22-14-10-7-11-15-22)18-16-24(17-19-25,27(3)4)21-12-8-6-9-13-21/h6-15H,16-20H2,1-5H3
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM239947
PNG
(US9403767, C-2)
Show SMILES CN(C)C1(CCC(O)(CC1)c1ccccc1)c1ccc(C)cc1
Show InChI InChI=1S/C21H27NO/c1-17-9-11-18(12-10-17)20(22(2)3)13-15-21(23,16-14-20)19-7-5-4-6-8-19/h4-12,23H,13-16H2,1-3H3
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Assay Description
The determination occurred in a homogeneous batch in microtiter plates. For this, dilution series of the respective substances to be tested were incu...


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More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239928
PNG
(US9403767, 107)
Show SMILES COc1ccc(CN(C)C2(CCC(CC2)(N(C)C)c2ccccc2)c2ccccc2)cc1
Show InChI InChI=1S/C29H36N2O/c1-30(2)28(25-11-7-5-8-12-25)19-21-29(22-20-28,26-13-9-6-10-14-26)31(3)23-24-15-17-27(32-4)18-16-24/h5-18H,19-23H2,1-4H3
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239945
PNG
(US9403767, 132)
Show SMILES CN(C)C1(CCC(CC1)(N1CCCC1)c1[nH]c2ccc(F)cc2c1C)c1ccccc1
Show InChI InChI=1S/C27H34FN3/c1-20-23-19-22(28)11-12-24(23)29-25(20)27(31-17-7-8-18-31)15-13-26(14-16-27,30(2)3)21-9-5-4-6-10-21/h4-6,9-12,19,29H,7-8,13-18H2,1-3H3
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GRUENENTHAL GMBH

US Patent


Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239888
PNG
(US9403767, 46 | US9403767, 47)
Show SMILES CCCCC1(CCC(CC1)(NC)c1ccccc1)N(C)C
Show InChI InChI=1S/C19H32N2/c1-5-6-12-18(21(3)4)13-15-19(20-2,16-14-18)17-10-8-7-9-11-17/h7-11,20H,5-6,12-16H2,1-4H3
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239932
PNG
(US9403767, 115)
Show SMILES CN(C)C1(CCC(CC1)(N(C)Cc1cccc(c1)C(F)(F)F)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C29H33F3N2/c1-33(2)27(24-12-6-4-7-13-24)17-19-28(20-18-27,25-14-8-5-9-15-25)34(3)22-23-11-10-16-26(21-23)29(30,31)32/h4-16,21H,17-20,22H2,1-3H3
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239907
PNG
(US9403767, 72 | US9403767, 73)
Show SMILES CN(C)C1(CCC(CC1)(N(C)C)c1ccc(cc1)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C23H29F3N2/c1-27(2)21(18-8-6-5-7-9-18)14-16-22(17-15-21,28(3)4)19-10-12-20(13-11-19)23(24,25)26/h5-13H,14-17H2,1-4H3
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239878
PNG
(US9403767, 34)
Show SMILES CN(C)CC1(Cc2ccccc2)CCC(CC1)(N(C)C)c1ccccc1
Show InChI InChI=1S/C24H34N2/c1-25(2)20-23(19-21-11-7-5-8-12-21)15-17-24(18-16-23,26(3)4)22-13-9-6-10-14-22/h5-14H,15-20H2,1-4H3
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239946
PNG
(US9403767, C-1)
Show SMILES CN(C)C1(CCC(O)(CC1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C20H25NO/c1-21(2)19(17-9-5-3-6-10-17)13-15-20(22,16-14-19)18-11-7-4-8-12-18/h3-12,22H,13-16H2,1-2H3
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239928
PNG
(US9403767, 107)
Show SMILES COc1ccc(CN(C)C2(CCC(CC2)(N(C)C)c2ccccc2)c2ccccc2)cc1
Show InChI InChI=1S/C29H36N2O/c1-30(2)28(25-11-7-5-8-12-25)19-21-29(22-20-28,26-13-9-6-10-14-26)31(3)23-24-15-17-27(32-4)18-16-24/h5-18H,19-23H2,1-4H3
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239941
PNG
(US9403767, 125)
Show SMILES CN(C)C1(CCC(CC1)(N(C)C)c1ccccc1)c1[nH]c2ccc(F)cc2c1C
Show InChI InChI=1S/C25H32FN3/c1-18-21-17-20(26)11-12-22(21)27-23(18)25(29(4)5)15-13-24(14-16-25,28(2)3)19-9-7-6-8-10-19/h6-12,17,27H,13-16H2,1-5H3
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM239946
PNG
(US9403767, C-1)
Show SMILES CN(C)C1(CCC(O)(CC1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C20H25NO/c1-21(2)19(17-9-5-3-6-10-17)13-15-20(22,16-14-19)18-11-7-4-8-12-18/h3-12,22H,13-16H2,1-2H3
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Assay Description
The determination occurred in a homogeneous batch in microtiter plates. For this, dilution series of the respective substances to be tested were incu...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239922
PNG
(US9403767, 100)
Show SMILES COc1ccc(Oc2nc(Oc3ccc(OC)cc3)nc(n2)N(C)C2(CCC(CC2)(N(C)C)c2ccccc2)c2ccccc2)cc1
Show InChI InChI=1S/C38H41N5O4/c1-42(2)37(28-12-8-6-9-13-28)24-26-38(27-25-37,29-14-10-7-11-15-29)43(3)34-39-35(46-32-20-16-30(44-4)17-21-32)41-36(40-34)47-33-22-18-31(45-5)19-23-33/h6-23H,24-27H2,1-5H3
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239880
PNG
(US9403767, 37)
Show SMILES CN(C)CC1(CCC(CC1)(N(C)C)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H32N2/c1-24(2)19-22(20-11-7-5-8-12-20)15-17-23(18-16-22,25(3)4)21-13-9-6-10-14-21/h5-14H,15-19H2,1-4H3
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239937
PNG
(US9403767, 121 | US9403767, 123)
Show SMILES CN(C)C(=O)CN(C)C1(CCC(CC1)(N(C)C)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H35N3O/c1-26(2)23(29)20-28(5)25(22-14-10-7-11-15-22)18-16-24(17-19-25,27(3)4)21-12-8-6-9-13-21/h6-15H,16-20H2,1-5H3
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239936
PNG
(US9403767, 120)
Show SMILES CN(C)C1(CCC(CC1)(N(C)CCO)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H32N2O/c1-24(2)22(20-10-6-4-7-11-20)14-16-23(17-15-22,25(3)18-19-26)21-12-8-5-9-13-21/h4-13,26H,14-19H2,1-3H3
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239946
PNG
(US9403767, C-1)
Show SMILES CN(C)C1(CCC(O)(CC1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C20H25NO/c1-21(2)19(17-9-5-3-6-10-17)13-15-20(22,16-14-19)18-11-7-4-8-12-18/h3-12,22H,13-16H2,1-2H3
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239909
PNG
(US9403767, 74 | US9403767, 75)
Show SMILES COc1ccc(cc1)C1(CCC(CC1)(N(C)C)c1ccccc1)N(C)C
Show InChI InChI=1S/C23H32N2O/c1-24(2)22(19-9-7-6-8-10-19)15-17-23(18-16-22,25(3)4)20-11-13-21(26-5)14-12-20/h6-14H,15-18H2,1-5H3
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239923
PNG
(US9403767, 101 | US9403767, 102)
Show SMILES CN(C)C1(CCC(CC1)(N(C)Cc1ccn(C)n1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C26H34N4/c1-28(2)25(22-11-7-5-8-12-22)16-18-26(19-17-25,23-13-9-6-10-14-23)29(3)21-24-15-20-30(4)27-24/h5-15,20H,16-19,21H2,1-4H3
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM239862
PNG
(US9403767, 12 | US9403767, 13)
Show SMILES CN(C)C1(Cc2ccccc2)CCC(CC1)(N(C)C)c1ccccc1
Show InChI InChI=1S/C23H32N2/c1-24(2)22(19-20-11-7-5-8-12-20)15-17-23(18-16-22,25(3)4)21-13-9-6-10-14-21/h5-14H,15-19H2,1-4H3
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Assay Description
The determination occurred in a homogeneous batch in microtiter plates. For this, dilution series of the respective substances to be tested were incu...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239877
PNG
(US9403767, 33)
Show SMILES CNC1(CCC(CN(C)C)(Cc2ccccc2)CC1)c1ccccc1
Show InChI InChI=1S/C23H32N2/c1-24-23(21-12-8-5-9-13-21)16-14-22(15-17-23,19-25(2)3)18-20-10-6-4-7-11-20/h4-13,24H,14-19H2,1-3H3
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM239903
PNG
(US9403767, 66 | US9403767, 67)
Show SMILES CN(C)C1(CCC(CC1)(N(C)CC(O)=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H30N2O2/c1-24(2)22(19-10-6-4-7-11-19)14-16-23(17-15-22,25(3)18-21(26)27)20-12-8-5-9-13-20/h4-13H,14-18H2,1-3H3,(H,26,27)
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Assay Description
The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239882
PNG
(US9403767, 40 | US9403767, 41)
Show SMILES CN(C)C1(CCC(CC1)(N(C)C)c1ccccc1)c1cccs1
Show InChI InChI=1S/C20H28N2S/c1-21(2)19(17-9-6-5-7-10-17)12-14-20(15-13-19,22(3)4)18-11-8-16-23-18/h5-11,16H,12-15H2,1-4H3
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239903
PNG
(US9403767, 66 | US9403767, 67)
Show SMILES CN(C)C1(CCC(CC1)(N(C)CC(O)=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H30N2O2/c1-24(2)22(19-10-6-4-7-11-19)14-16-23(17-15-22,25(3)18-21(26)27)20-12-8-5-9-13-20/h4-13H,14-18H2,1-3H3,(H,26,27)
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239944
PNG
(US9403767, 131)
Show SMILES CN(C)C1(CCC(CC1)(N(C)C(=O)CCC(O)=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H32N2O3/c1-26(2)24(20-10-6-4-7-11-20)16-18-25(19-17-24,21-12-8-5-9-13-21)27(3)22(28)14-15-23(29)30/h4-13H,14-19H2,1-3H3,(H,29,30)
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US Patent


Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM239903
PNG
(US9403767, 66 | US9403767, 67)
Show SMILES CN(C)C1(CCC(CC1)(N(C)CC(O)=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H30N2O2/c1-24(2)22(19-10-6-4-7-11-19)14-16-23(17-15-22,25(3)18-21(26)27)20-12-8-5-9-13-20/h4-13H,14-18H2,1-3H3,(H,26,27)
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Assay Description
The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%