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Patent code US9403799

Compile Data Set for Download or QSAR
Found 14 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM237162
PNG
(US9403799, A1 | US9403799, A2 | US9403799, A3 | US...)
Show SMILES Cn1cc(cn1)-c1ccc(=O)n(Cc2cccc(c2)-c2ncc(OCCN3CCOCC3)cn2)n1
Show InChI InChI=1S/C25H27N7O3/c1-30-18-21(14-28-30)23-5-6-24(33)32(29-23)17-19-3-2-4-20(13-19)25-26-15-22(16-27-25)35-12-9-31-7-10-34-11-8-31/h2-6,13-16,18H,7-12,17H2,1H3
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UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



MERCK PATENT GMBH

US Patent


Assay Description
The test plates used are 96-well Flashplate® microtitre plates from Perkin Elmer (Cat. No. SMP200). The components of the kinase reaction describ...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM237162
PNG
(US9403799, A1 | US9403799, A2 | US9403799, A3 | US...)
Show SMILES Cn1cc(cn1)-c1ccc(=O)n(Cc2cccc(c2)-c2ncc(OCCN3CCOCC3)cn2)n1
Show InChI InChI=1S/C25H27N7O3/c1-30-18-21(14-28-30)23-5-6-24(33)32(29-23)17-19-3-2-4-20(13-19)25-26-15-22(16-27-25)35-12-9-31-7-10-34-11-8-31/h2-6,13-16,18H,7-12,17H2,1H3
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US Patent
n/an/a<100n/an/an/an/an/an/a



MERCK PATENT GMBH

US Patent


Assay Description
The test plates used are 96-well Flashplate® microtitre plates from Perkin Elmer (Cat. No. SMP200). The components of the kinase reaction describ...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50065457
PNG
(EMD-1214063 | MSC-2156119 | MSC-2156119J | Tepotin...)
Show SMILES CN1CCC(COc2cnc(nc2)-c2cccc(Cn3nc(ccc3=O)-c3cccc(c3)C#N)c2)CC1
Show InChI InChI=1S/C29H28N6O2/c1-34-12-10-21(11-13-34)20-37-26-17-31-29(32-18-26)25-7-3-5-23(15-25)19-35-28(36)9-8-27(33-35)24-6-2-4-22(14-24)16-30/h2-9,14-15,17-18,21H,10-13,19-20H2,1H3
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n/an/a<100n/an/an/an/an/an/a



MERCK PATENT GMBH

US Patent


Assay Description
The test plates used are 96-well Flashplate® microtitre plates from Perkin Elmer (Cat. No. SMP200). The components of the kinase reaction describ...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50065457
PNG
(EMD-1214063 | MSC-2156119 | MSC-2156119J | Tepotin...)
Show SMILES CN1CCC(COc2cnc(nc2)-c2cccc(Cn3nc(ccc3=O)-c3cccc(c3)C#N)c2)CC1
Show InChI InChI=1S/C29H28N6O2/c1-34-12-10-21(11-13-34)20-37-26-17-31-29(32-18-26)25-7-3-5-23(15-25)19-35-28(36)9-8-27(33-35)24-6-2-4-22(14-24)16-30/h2-9,14-15,17-18,21H,10-13,19-20H2,1H3
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n/an/a<100n/an/an/an/an/an/a



MERCK PATENT GMBH

US Patent


Assay Description
The test plates used are 96-well Flashplate® microtitre plates from Perkin Elmer (Cat. No. SMP200). The components of the kinase reaction describ...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50065457
PNG
(EMD-1214063 | MSC-2156119 | MSC-2156119J | Tepotin...)
Show SMILES CN1CCC(COc2cnc(nc2)-c2cccc(Cn3nc(ccc3=O)-c3cccc(c3)C#N)c2)CC1
Show InChI InChI=1S/C29H28N6O2/c1-34-12-10-21(11-13-34)20-37-26-17-31-29(32-18-26)25-7-3-5-23(15-25)19-35-28(36)9-8-27(33-35)24-6-2-4-22(14-24)16-30/h2-9,14-15,17-18,21H,10-13,19-20H2,1H3
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n/an/a<100n/an/an/an/an/an/a



MERCK PATENT GMBH

US Patent


Assay Description
The test plates used are 96-well Flashplate® microtitre plates from Perkin Elmer (Cat. No. SMP200). The components of the kinase reaction describ...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM237162
PNG
(US9403799, A1 | US9403799, A2 | US9403799, A3 | US...)
Show SMILES Cn1cc(cn1)-c1ccc(=O)n(Cc2cccc(c2)-c2ncc(OCCN3CCOCC3)cn2)n1
Show InChI InChI=1S/C25H27N7O3/c1-30-18-21(14-28-30)23-5-6-24(33)32(29-23)17-19-3-2-4-20(13-19)25-26-15-22(16-27-25)35-12-9-31-7-10-34-11-8-31/h2-6,13-16,18H,7-12,17H2,1H3
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n/an/a<100n/an/an/an/an/an/a



MERCK PATENT GMBH

US Patent


Assay Description
The test plates used are 96-well Flashplate® microtitre plates from Perkin Elmer (Cat. No. SMP200). The components of the kinase reaction describ...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM237162
PNG
(US9403799, A1 | US9403799, A2 | US9403799, A3 | US...)
Show SMILES Cn1cc(cn1)-c1ccc(=O)n(Cc2cccc(c2)-c2ncc(OCCN3CCOCC3)cn2)n1
Show InChI InChI=1S/C25H27N7O3/c1-30-18-21(14-28-30)23-5-6-24(33)32(29-23)17-19-3-2-4-20(13-19)25-26-15-22(16-27-25)35-12-9-31-7-10-34-11-8-31/h2-6,13-16,18H,7-12,17H2,1H3
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UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



MERCK PATENT GMBH

US Patent


Assay Description
The test plates used are 96-well Flashplate® microtitre plates from Perkin Elmer (Cat. No. SMP200). The components of the kinase reaction describ...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50065457
PNG
(EMD-1214063 | MSC-2156119 | MSC-2156119J | Tepotin...)
Show SMILES CN1CCC(COc2cnc(nc2)-c2cccc(Cn3nc(ccc3=O)-c3cccc(c3)C#N)c2)CC1
Show InChI InChI=1S/C29H28N6O2/c1-34-12-10-21(11-13-34)20-37-26-17-31-29(32-18-26)25-7-3-5-23(15-25)19-35-28(36)9-8-27(33-35)24-6-2-4-22(14-24)16-30/h2-9,14-15,17-18,21H,10-13,19-20H2,1H3
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n/an/a<100n/an/an/an/an/an/a



MERCK PATENT GMBH

US Patent


Assay Description
The test plates used are 96-well Flashplate® microtitre plates from Perkin Elmer (Cat. No. SMP200). The components of the kinase reaction describ...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM237162
PNG
(US9403799, A1 | US9403799, A2 | US9403799, A3 | US...)
Show SMILES Cn1cc(cn1)-c1ccc(=O)n(Cc2cccc(c2)-c2ncc(OCCN3CCOCC3)cn2)n1
Show InChI InChI=1S/C25H27N7O3/c1-30-18-21(14-28-30)23-5-6-24(33)32(29-23)17-19-3-2-4-20(13-19)25-26-15-22(16-27-25)35-12-9-31-7-10-34-11-8-31/h2-6,13-16,18H,7-12,17H2,1H3
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n/an/a<100n/an/an/an/an/an/a



MERCK PATENT GMBH

US Patent


Assay Description
The test plates used are 96-well Flashplate® microtitre plates from Perkin Elmer (Cat. No. SMP200). The components of the kinase reaction describ...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM237162
PNG
(US9403799, A1 | US9403799, A2 | US9403799, A3 | US...)
Show SMILES Cn1cc(cn1)-c1ccc(=O)n(Cc2cccc(c2)-c2ncc(OCCN3CCOCC3)cn2)n1
Show InChI InChI=1S/C25H27N7O3/c1-30-18-21(14-28-30)23-5-6-24(33)32(29-23)17-19-3-2-4-20(13-19)25-26-15-22(16-27-25)35-12-9-31-7-10-34-11-8-31/h2-6,13-16,18H,7-12,17H2,1H3
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US Patent
n/an/a<100n/an/an/an/an/an/a



MERCK PATENT GMBH

US Patent


Assay Description
The test plates used are 96-well Flashplate® microtitre plates from Perkin Elmer (Cat. No. SMP200). The components of the kinase reaction describ...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50065457
PNG
(EMD-1214063 | MSC-2156119 | MSC-2156119J | Tepotin...)
Show SMILES CN1CCC(COc2cnc(nc2)-c2cccc(Cn3nc(ccc3=O)-c3cccc(c3)C#N)c2)CC1
Show InChI InChI=1S/C29H28N6O2/c1-34-12-10-21(11-13-34)20-37-26-17-31-29(32-18-26)25-7-3-5-23(15-25)19-35-28(36)9-8-27(33-35)24-6-2-4-22(14-24)16-30/h2-9,14-15,17-18,21H,10-13,19-20H2,1H3
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n/an/a<100n/an/an/an/an/an/a



MERCK PATENT GMBH

US Patent


Assay Description
The test plates used are 96-well Flashplate® microtitre plates from Perkin Elmer (Cat. No. SMP200). The components of the kinase reaction describ...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50065457
PNG
(EMD-1214063 | MSC-2156119 | MSC-2156119J | Tepotin...)
Show SMILES CN1CCC(COc2cnc(nc2)-c2cccc(Cn3nc(ccc3=O)-c3cccc(c3)C#N)c2)CC1
Show InChI InChI=1S/C29H28N6O2/c1-34-12-10-21(11-13-34)20-37-26-17-31-29(32-18-26)25-7-3-5-23(15-25)19-35-28(36)9-8-27(33-35)24-6-2-4-22(14-24)16-30/h2-9,14-15,17-18,21H,10-13,19-20H2,1H3
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n/an/a<100n/an/an/an/an/an/a



MERCK PATENT GMBH

US Patent


Assay Description
The test plates used are 96-well Flashplate® microtitre plates from Perkin Elmer (Cat. No. SMP200). The components of the kinase reaction describ...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50065457
PNG
(EMD-1214063 | MSC-2156119 | MSC-2156119J | Tepotin...)
Show SMILES CN1CCC(COc2cnc(nc2)-c2cccc(Cn3nc(ccc3=O)-c3cccc(c3)C#N)c2)CC1
Show InChI InChI=1S/C29H28N6O2/c1-34-12-10-21(11-13-34)20-37-26-17-31-29(32-18-26)25-7-3-5-23(15-25)19-35-28(36)9-8-27(33-35)24-6-2-4-22(14-24)16-30/h2-9,14-15,17-18,21H,10-13,19-20H2,1H3
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n/an/a<100n/an/an/an/an/an/a



MERCK PATENT GMBH

US Patent


Assay Description
The test plates used are 96-well Flashplate® microtitre plates from Perkin Elmer (Cat. No. SMP200). The components of the kinase reaction describ...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50065457
PNG
(EMD-1214063 | MSC-2156119 | MSC-2156119J | Tepotin...)
Show SMILES CN1CCC(COc2cnc(nc2)-c2cccc(Cn3nc(ccc3=O)-c3cccc(c3)C#N)c2)CC1
Show InChI InChI=1S/C29H28N6O2/c1-34-12-10-21(11-13-34)20-37-26-17-31-29(32-18-26)25-7-3-5-23(15-25)19-35-28(36)9-8-27(33-35)24-6-2-4-22(14-24)16-30/h2-9,14-15,17-18,21H,10-13,19-20H2,1H3
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n/an/a<100n/an/an/an/an/an/a



MERCK PATENT GMBH

US Patent


Assay Description
The test plates used are 96-well Flashplate® microtitre plates from Perkin Elmer (Cat. No. SMP200). The components of the kinase reaction describ...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
* indicates data uncertainty>20%