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Patent code US9403803

Compile Data Set for Download or QSAR
Found 15 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM238842
PNG
(US9403803, 2)
Show SMILES NC(=O)c1c([nH]c2ccccc12)-c1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C23H17F3N4O2/c24-23(25,26)14-4-3-5-16(12-14)29-22(32)28-15-10-8-13(9-11-15)20-19(21(27)31)17-6-1-2-7-18(17)30-20/h1-12,30H,(H2,27,31)(H2,28,29,32)
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n/an/a 7n/an/an/an/an/an/a



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM238844
PNG
(US9403803, 4)
Show SMILES CCc1cccc(NC(=O)Nc2ccc(cc2)-c2[nH]c3ccccc3c2C(N)=O)c1
Show InChI InChI=1S/C24H22N4O2/c1-2-15-6-5-7-18(14-15)27-24(30)26-17-12-10-16(11-13-17)22-21(23(25)29)19-8-3-4-9-20(19)28-22/h3-14,28H,2H2,1H3,(H2,25,29)(H2,26,27,30)
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Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM238841
PNG
(US9403803, 1)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2[nH]c3ccccc3c2C(N)=O)c1
Show InChI InChI=1S/C23H20N4O2/c1-14-5-4-6-17(13-14)26-23(29)25-16-11-9-15(10-12-16)21-20(22(24)28)18-7-2-3-8-19(18)27-21/h2-13,27H,1H3,(H2,24,28)(H2,25,26,29)
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Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM238843
PNG
(US9403803, 3)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2[nH]c3ccccc3c2C(N)=O)c1
Show InChI InChI=1S/C23H19FN4O2/c1-13-6-11-17(24)19(12-13)28-23(30)26-15-9-7-14(8-10-15)21-20(22(25)29)16-4-2-3-5-18(16)27-21/h2-12,27H,1H3,(H2,25,29)(H2,26,28,30)
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Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM238844
PNG
(US9403803, 4)
Show SMILES CCc1cccc(NC(=O)Nc2ccc(cc2)-c2[nH]c3ccccc3c2C(N)=O)c1
Show InChI InChI=1S/C24H22N4O2/c1-2-15-6-5-7-18(14-15)27-24(30)26-17-12-10-16(11-13-17)22-21(23(25)29)19-8-3-4-9-20(19)28-22/h3-14,28H,2H2,1H3,(H2,25,29)(H2,26,27,30)
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Allergan, Inc.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in 1...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM238842
PNG
(US9403803, 2)
Show SMILES NC(=O)c1c([nH]c2ccccc12)-c1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C23H17F3N4O2/c24-23(25,26)14-4-3-5-16(12-14)29-22(32)28-15-10-8-13(9-11-15)20-19(21(27)31)17-6-1-2-7-18(17)30-20/h1-12,30H,(H2,27,31)(H2,28,29,32)
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Allergan, Inc.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in 1...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM238841
PNG
(US9403803, 1)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2[nH]c3ccccc3c2C(N)=O)c1
Show InChI InChI=1S/C23H20N4O2/c1-14-5-4-6-17(13-14)26-23(29)25-16-11-9-15(10-12-16)21-20(22(24)28)18-7-2-3-8-19(18)27-21/h2-13,27H,1H3,(H2,24,28)(H2,25,26,29)
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Allergan, Inc.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in 1...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM238843
PNG
(US9403803, 3)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2[nH]c3ccccc3c2C(N)=O)c1
Show InChI InChI=1S/C23H19FN4O2/c1-13-6-11-17(24)19(12-13)28-23(30)26-15-9-7-14(8-10-15)21-20(22(25)29)16-4-2-3-5-18(16)27-21/h2-12,27H,1H3,(H2,25,29)(H2,26,28,30)
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Allergan, Inc.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in 1...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM238850
PNG
(US9403803, 10)
Show SMILES Cc1ccc(F)c(c1)C(=O)Nc1cccc(c1)-c1[nH]c2ccccc2c1C(N)=O
Show InChI InChI=1S/C23H18FN3O2/c1-13-9-10-18(24)17(11-13)23(29)26-15-6-4-5-14(12-15)21-20(22(25)28)16-7-2-3-8-19(16)27-21/h2-12,27H,1H3,(H2,25,28)(H,26,29)
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Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM238846
PNG
(US9403803, 6)
Show SMILES Cc1ccc(F)c(c1)C(=O)Nc1ccc(cc1)-c1[nH]c2ccccc2c1C(N)=O
Show InChI InChI=1S/C23H18FN3O2/c1-13-6-11-18(24)17(12-13)23(29)26-15-9-7-14(8-10-15)21-20(22(25)28)16-4-2-3-5-19(16)27-21/h2-12,27H,1H3,(H2,25,28)(H,26,29)
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Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM238845
PNG
(US9403803, 5)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(cc1)-c1[nH]c2ccccc2c1C(N)=O
Show InChI InChI=1S/C21H17N3O3/c1-12-10-11-27-19(12)21(26)23-14-8-6-13(7-9-14)18-17(20(22)25)15-4-2-3-5-16(15)24-18/h2-11,24H,1H3,(H2,22,25)(H,23,26)
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Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM238849
PNG
(US9403803, 9)
Show SMILES Cc1ccoc1C(=O)Nc1cccc(c1)-c1[nH]c2ccccc2c1C(N)=O
Show InChI InChI=1S/C21H17N3O3/c1-12-9-10-27-19(12)21(26)23-14-6-4-5-13(11-14)18-17(20(22)25)15-7-2-3-8-16(15)24-18/h2-11,24H,1H3,(H2,22,25)(H,23,26)
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Allergan, Inc.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in 1...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM238847
PNG
(US9403803, 7)
Show SMILES Cc1cccc(NC(=O)Nc2cccc(c2)-c2[nH]c3ccccc3c2C(N)=O)c1
Show InChI InChI=1S/C23H20N4O2/c1-14-6-4-8-16(12-14)25-23(29)26-17-9-5-7-15(13-17)21-20(22(24)28)18-10-2-3-11-19(18)27-21/h2-13,27H,1H3,(H2,24,28)(H2,25,26,29)
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Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM238848
PNG
(US9403803, 8)
Show SMILES NC(=O)c1c([nH]c2ccccc12)-c1cccc(NC(=O)Nc2cccc(c2)C(F)(F)F)c1
Show InChI InChI=1S/C23H17F3N4O2/c24-23(25,26)14-6-4-8-16(12-14)29-22(32)28-15-7-3-5-13(11-15)20-19(21(27)31)17-9-1-2-10-18(17)30-20/h1-12,30H,(H2,27,31)(H2,28,29,32)
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Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM238849
PNG
(US9403803, 9)
Show SMILES Cc1ccoc1C(=O)Nc1cccc(c1)-c1[nH]c2ccccc2c1C(N)=O
Show InChI InChI=1S/C21H17N3O3/c1-12-9-10-27-19(12)21(26)23-14-6-4-5-13(11-14)18-17(20(22)25)15-7-2-3-8-16(15)24-18/h2-11,24H,1H3,(H2,22,25)(H,23,26)
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Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%