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Patent code US9403804

Compile Data Set for Download or QSAR
Found 10 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238225
PNG
(US9403804, 2)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)[C@@]1(O)CC[C@@H](CC1)C(O)=O
Show InChI InChI=1S/C26H30N4O4/c1-25(2)9-5-16(6-10-25)20-13-18(26(34)11-7-17(8-12-26)24(32)33)3-4-21(20)30-23(31)22-28-15-19(14-27)29-22/h3-5,13,15,17,34H,6-12H2,1-2H3,(H,28,29)(H,30,31)(H,32,33)/t17-,26+
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UniChem
US Patent
n/an/a 0.650n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238233
PNG
(US9403804, 44)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1nc(c[nH]1)C#N)[C@@]1(O)CC[C@@H](CC1)N1CCOCC1
Show InChI InChI=1S/C29H37N5O3/c1-28(2)9-5-20(6-10-28)24-17-21(3-4-25(24)33-27(35)26-31-19-22(18-30)32-26)29(36)11-7-23(8-12-29)34-13-15-37-16-14-34/h3-5,17,19,23,36H,6-16H2,1-2H3,(H,31,32)(H,33,35)/t23-,29+
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US Patent
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Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238230
PNG
(US9403804, 28)
Show SMILES CN1CCN(CC1)C1CCC(CC1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C30H40N6O/c1-30(2)12-10-22(11-13-30)26-18-23(6-9-27(26)34-29(37)28-32-20-24(19-31)33-28)21-4-7-25(8-5-21)36-16-14-35(3)15-17-36/h6,9-10,18,20-21,25H,4-5,7-8,11-17H2,1-3H3,(H,32,33)(H,34,37)
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US Patent
n/an/a 0.990n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238229
PNG
(US9403804, 27)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1nc(c[nH]1)C#N)C1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C29H37N5O2/c1-29(2)11-9-21(10-12-29)25-17-22(20-3-6-24(7-4-20)34-13-15-36-16-14-34)5-8-26(25)33-28(35)27-31-19-23(18-30)32-27/h5,8-9,17,19-20,24H,3-4,6-7,10-16H2,1-2H3,(H,31,32)(H,33,35)
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n/an/a 1.90n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238226
PNG
(US9403804, 3)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1nc(c[nH]1)C#N)C1(O)CCCC1
Show InChI InChI=1S/C24H28N4O2/c1-23(2)11-7-16(8-12-23)19-13-17(24(30)9-3-4-10-24)5-6-20(19)28-22(29)21-26-15-18(14-25)27-21/h5-7,13,15,30H,3-4,8-12H2,1-2H3,(H,26,27)(H,28,29)
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US Patent
n/an/a 2.30n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238231
PNG
(US9403804, 43)
Show SMILES COCCNC1(CCCCC1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C28H37N5O2/c1-27(2)13-9-20(10-14-27)23-17-21(28(31-15-16-35-3)11-5-4-6-12-28)7-8-24(23)33-26(34)25-30-19-22(18-29)32-25/h7-9,17,19,31H,4-6,10-16H2,1-3H3,(H,30,32)(H,33,34)
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US Patent
n/an/a 2.90n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238232
PNG
(US9403804, 45)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1nc(c[nH]1)C#N)[C@]1(O)CC[C@@H](CC1)N1CCOCC1
Show InChI InChI=1S/C29H37N5O3/c1-28(2)9-5-20(6-10-28)24-17-21(3-4-25(24)33-27(35)26-31-19-22(18-30)32-26)29(36)11-7-23(8-12-29)34-13-15-37-16-14-34/h3-5,17,19,23,36H,6-16H2,1-2H3,(H,31,32)(H,33,35)/t23-,29-
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n/an/a 3.40n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238224
PNG
(US9403804, 1)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1nc(c[nH]1)C#N)C1(O)CCCCC1
Show InChI InChI=1S/C25H30N4O2/c1-24(2)12-8-17(9-13-24)20-14-18(25(31)10-4-3-5-11-25)6-7-21(20)29-23(30)22-27-16-19(15-26)28-22/h6-8,14,16,31H,3-5,9-13H2,1-2H3,(H,27,28)(H,29,30)
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n/an/a 5.90n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238227
PNG
(US9403804, 4)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1nc(c[nH]1)C#N)C1(CC1)C#N
Show InChI InChI=1S/C23H23N5O/c1-22(2)7-5-15(6-8-22)18-11-16(23(14-25)9-10-23)3-4-19(18)28-21(29)20-26-13-17(12-24)27-20/h3-5,11,13H,6-10H2,1-2H3,(H,26,27)(H,28,29)
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US Patent
n/an/a 9.5n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM238228
PNG
(US9403804, 14)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1nc(c[nH]1)C#N)C1(CCCCC1)C#N
Show InChI InChI=1S/C26H29N5O/c1-25(2)12-8-18(9-13-25)21-14-19(26(17-28)10-4-3-5-11-26)6-7-22(21)31-24(32)23-29-16-20(15-27)30-23/h6-8,14,16H,3-5,9-13H2,1-2H3,(H,29,30)(H,31,32)
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US Patent
n/an/a 20n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%