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Patent code US9403808

Compile Data Set for Download or QSAR
Found 195 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM239990
PNG
(US9403808, 1)
Show SMILES Cc1nc(no1)C(C)(C)NC(=O)c1cnc(C2CC2)c(n1)-c1cccc(Cl)c1
Show InChI InChI=1S/C20H20ClN5O2/c1-11-23-19(26-28-11)20(2,3)25-18(27)15-10-22-16(12-7-8-12)17(24-15)13-5-4-6-14(21)9-13/h4-6,9-10,12H,7-8H2,1-3H3,(H,25,27)
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n/an/an/an/a 88.1n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM239995
PNG
(US9403808, 6)
Show SMILES CC(C)(NC(=O)c1cnc(C2CC2)c(n1)-c1cccc(Cl)c1)c1nccs1
Show InChI InChI=1S/C20H19ClN4OS/c1-20(2,19-22-8-9-27-19)25-18(26)15-11-23-16(12-6-7-12)17(24-15)13-4-3-5-14(21)10-13/h3-5,8-12H,6-7H2,1-2H3,(H,25,26)
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n/an/an/an/a 48n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM239996
PNG
(US9403808, 7)
Show SMILES Clc1cccc(c1)-c1nc(cnc1C1CC1)C(=O)NN1CCCCC1
Show InChI InChI=1S/C19H21ClN4O/c20-15-6-4-5-14(11-15)18-17(13-7-8-13)21-12-16(22-18)19(25)23-24-9-2-1-3-10-24/h4-6,11-13H,1-3,7-10H2,(H,23,25)
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n/an/an/an/a 255n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM239997
PNG
(US9403808, 8)
Show SMILES CNC(=O)[C@@H](NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(C)(C)C
Show InChI InChI=1S/C19H27F2N5O3/c1-18(2,3)13(16(28)22-4)25-15(27)12-7-23-14(26-9-19(20,21)10-26)17(24-12)29-8-11-5-6-11/h7,11,13H,5-6,8-10H2,1-4H3,(H,22,28)(H,25,27)/t13-/m1/s1
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n/an/an/an/a 18.5n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240002
PNG
(US9403808, 13)
Show SMILES CCC(C)(CO)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C17H25N3O3/c1-3-17(2,10-21)20-15(22)13-8-18-14(12-6-7-12)16(19-13)23-9-11-4-5-11/h8,11-12,21H,3-7,9-10H2,1-2H3,(H,20,22)
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n/an/an/an/a 63.4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240007
PNG
(US9403808, 18)
Show SMILES O=C(NN1CCCCC1)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C17H24N4O2/c22-16(20-21-8-2-1-3-9-21)14-10-18-15(13-6-7-13)17(19-14)23-11-12-4-5-12/h10,12-13H,1-9,11H2,(H,20,22)
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n/an/an/an/a 327n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240009
PNG
(US9403808, 20)
Show SMILES Cc1nc(no1)[C@H](CC1CC1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H24F2N6O3/c1-11-24-16(27-31-11)14(6-12-2-3-12)25-18(29)15-7-23-17(28-9-20(21,22)10-28)19(26-15)30-8-13-4-5-13/h7,12-14H,2-6,8-10H2,1H3,(H,25,29)/t14-/m0/s1
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n/an/an/an/a 28.4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240054
PNG
(US9403808, 65)
Show SMILES Cc1nc(no1)[C@H](CC1CC1)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H25N5O3/c1-11-22-18(25-28-11)15(8-12-2-3-12)23-19(26)16-9-21-17(14-6-7-14)20(24-16)27-10-13-4-5-13/h9,12-15H,2-8,10H2,1H3,(H,23,26)/t15-/m0/s1
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n/an/an/an/a 20.7n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240059
PNG
(US9403808, 70)
Show SMILES CC(C)(CCc1ccncc1)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C22H28N4O2/c1-22(2,10-7-15-8-11-23-12-9-15)26-20(27)18-13-24-19(17-5-6-17)21(25-18)28-14-16-3-4-16/h8-9,11-13,16-17H,3-7,10,14H2,1-2H3,(H,26,27)
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n/an/an/an/a 280n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240043
PNG
(US9403808, 54 | US9403808, 74)
Show SMILES Cc1csc(n1)C(C)(C)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H24N4O2S/c1-11-10-26-18(21-11)19(2,3)23-16(24)14-8-20-15(13-6-7-13)17(22-14)25-9-12-4-5-12/h8,10,12-13H,4-7,9H2,1-3H3,(H,23,24)
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n/an/an/an/a 11.6n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240073
PNG
(US9403808, 84)
Show SMILES NC(=O)CC1(COC1)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C17H22N4O4/c18-13(22)5-17(8-24-9-17)21-15(23)12-6-19-14(11-3-4-11)16(20-12)25-7-10-1-2-10/h6,10-11H,1-5,7-9H2,(H2,18,22)(H,21,23)
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n/an/an/an/a 14.6n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240088
PNG
(US9403808, 99)
Show SMILES COCCC(C)(C)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C18H26F2N4O3/c1-17(2,6-7-26-3)23-15(25)13-8-21-14(24-10-18(19,20)11-24)16(22-13)27-9-12-4-5-12/h8,12H,4-7,9-11H2,1-3H3,(H,23,25)
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n/an/an/an/a 10.3n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240089
PNG
(US9403808, 100)
Show SMILES OCC(CC1CCC1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H26F2N4O3/c20-19(21)10-25(11-19)16-18(28-9-13-4-5-13)24-15(7-22-16)17(27)23-14(8-26)6-12-2-1-3-12/h7,12-14,26H,1-6,8-11H2,(H,23,27)
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n/an/an/an/a 7.30n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240090
PNG
(US9403808, 101)
Show SMILES NC(=O)C(CC1CCC1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H25F2N5O3/c20-19(21)9-26(10-19)16-18(29-8-12-4-5-12)25-14(7-23-16)17(28)24-13(15(22)27)6-11-2-1-3-11/h7,11-13H,1-6,8-10H2,(H2,22,27)(H,24,28)
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n/an/an/an/a 5.60n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM239991
PNG
(US9403808, 2)
Show SMILES CC(C)(NC(=O)c1cnc(C2CC2)c(n1)-c1cccc(Cl)c1)C#N
Show InChI InChI=1S/C18H17ClN4O/c1-18(2,10-20)23-17(24)14-9-21-15(11-6-7-11)16(22-14)12-4-3-5-13(19)8-12/h3-5,8-9,11H,6-7H2,1-2H3,(H,23,24)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM239993
PNG
(US9403808, 4)
Show SMILES Cc1nc(no1)C(C)(C)NC(=O)c1cnc(N2CC(F)(F)C2)c(n1)-c1cccc(Cl)c1
Show InChI InChI=1S/C20H19ClF2N6O2/c1-11-25-18(28-31-11)19(2,3)27-17(30)14-8-24-16(29-9-20(22,23)10-29)15(26-14)12-5-4-6-13(21)7-12/h4-8H,9-10H2,1-3H3,(H,27,30)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM239994
PNG
(US9403808, 5)
Show SMILES Cc1nc(no1)C(C)(C)NC(=O)c1cnc(N2CCC2)c(n1)-c1cccc(Cl)c1
Show InChI InChI=1S/C20H21ClN6O2/c1-12-23-19(26-29-12)20(2,3)25-18(28)15-11-22-17(27-8-5-9-27)16(24-15)13-6-4-7-14(21)10-13/h4,6-7,10-11H,5,8-9H2,1-3H3,(H,25,28)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240002
PNG
(US9403808, 13)
Show SMILES CCC(C)(CO)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C17H25N3O3/c1-3-17(2,10-21)20-15(22)13-8-18-14(12-6-7-12)16(19-13)23-9-11-4-5-11/h8,11-12,21H,3-7,9-10H2,1-2H3,(H,20,22)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240015
PNG
(US9403808, 26)
Show SMILES CNC(=O)[C@H](CC(C)C)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H28N4O3/c1-11(2)8-14(17(24)20-3)22-18(25)15-9-21-16(13-6-7-13)19(23-15)26-10-12-4-5-12/h9,11-14H,4-8,10H2,1-3H3,(H,20,24)(H,22,25)/t14-/m0/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240033
PNG
(US9403808, 44)
Show SMILES CC(C)(C)[C@H](NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1)C(O)=O
Show InChI InChI=1S/C18H25N3O4/c1-18(2,3)14(17(23)24)21-15(22)12-8-19-13(11-6-7-11)16(20-12)25-9-10-4-5-10/h8,10-11,14H,4-7,9H2,1-3H3,(H,21,22)(H,23,24)/t14-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240034
PNG
(US9403808, 45)
Show SMILES Cc1nc(no1)C(C)(C)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C18H23N5O3/c1-10-20-17(23-26-10)18(2,3)22-15(24)13-8-19-14(12-6-7-12)16(21-13)25-9-11-4-5-11/h8,11-12H,4-7,9H2,1-3H3,(H,22,24)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240036
PNG
(US9403808, 47)
Show SMILES FC(F)(F)[C@H](NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)c1ccccn1
Show InChI InChI=1S/C19H18F5N5O2/c20-18(21)9-29(10-18)15-17(31-8-11-4-5-11)27-13(7-26-15)16(30)28-14(19(22,23)24)12-3-1-2-6-25-12/h1-3,6-7,11,14H,4-5,8-10H2,(H,28,30)/t14-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240039
PNG
(US9403808, 50)
Show SMILES CCC(CC)(NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(=O)NC
Show InChI InChI=1S/C19H27F2N5O3/c1-4-18(5-2,17(28)22-3)25-15(27)13-8-23-14(26-10-19(20,21)11-26)16(24-13)29-9-12-6-7-12/h8,12H,4-7,9-11H2,1-3H3,(H,22,28)(H,25,27)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240075
PNG
(US9403808, 86)
Show SMILES Cc1nc(no1)[C@@](C)(NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)C1CC1
Show InChI InChI=1S/C20H24F2N6O3/c1-11-24-18(27-31-11)19(2,13-5-6-13)26-16(29)14-7-23-15(28-9-20(21,22)10-28)17(25-14)30-8-12-3-4-12/h7,12-13H,3-6,8-10H2,1-2H3,(H,26,29)/t19-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240084
PNG
(US9403808, 95)
Show SMILES COCCC(C)(C)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C18H27N3O3/c1-18(2,8-9-23-3)21-16(22)14-10-19-15(13-6-7-13)17(20-14)24-11-12-4-5-12/h10,12-13H,4-9,11H2,1-3H3,(H,21,22)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM239991
PNG
(US9403808, 2)
Show SMILES CC(C)(NC(=O)c1cnc(C2CC2)c(n1)-c1cccc(Cl)c1)C#N
Show InChI InChI=1S/C18H17ClN4O/c1-18(2,10-20)23-17(24)14-9-21-15(11-6-7-11)16(22-14)12-4-3-5-13(19)8-12/h3-5,8-9,11H,6-7H2,1-2H3,(H,23,24)
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n/an/an/an/a 104n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM239998
PNG
(US9403808, 9)
Show SMILES Cc1nc(no1)C1(CCC1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H22F2N6O3/c1-11-23-17(26-30-11)18(5-2-6-18)25-15(28)13-7-22-14(27-9-19(20,21)10-27)16(24-13)29-8-12-3-4-12/h7,12H,2-6,8-10H2,1H3,(H,25,28)
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n/an/an/an/a 87.9n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240004
PNG
(US9403808, 15)
Show SMILES NC(=O)[C@@H](NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1)c1ccccc1
Show InChI InChI=1S/C20H22N4O3/c21-18(25)16(13-4-2-1-3-5-13)24-19(26)15-10-22-17(14-8-9-14)20(23-15)27-11-12-6-7-12/h1-5,10,12,14,16H,6-9,11H2,(H2,21,25)(H,24,26)/t16-/m0/s1
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n/an/an/an/a 141n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240008
PNG
(US9403808, 19)
Show SMILES CC(C)(C)C(CO)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C18H27N3O3/c1-18(2,3)14(9-22)21-16(23)13-8-19-15(12-6-7-12)17(20-13)24-10-11-4-5-11/h8,11-12,14,22H,4-7,9-10H2,1-3H3,(H,21,23)
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n/an/an/an/a 53.5n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240022
PNG
(US9403808, 33)
Show SMILES CNC(=O)[C@H](CC(C)C)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H27F2N5O3/c1-11(2)6-13(16(27)22-3)24-17(28)14-7-23-15(26-9-19(20,21)10-26)18(25-14)29-8-12-4-5-12/h7,11-13H,4-6,8-10H2,1-3H3,(H,22,27)(H,24,28)/t13-/m0/s1
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n/an/an/an/a 11.8n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240032
PNG
(US9403808, 43)
Show SMILES Cc1nc(no1)[C@H](NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)C1CC1
Show InChI InChI=1S/C19H22F2N6O3/c1-10-23-15(26-30-10)14(12-4-5-12)25-17(28)13-6-22-16(27-8-19(20,21)9-27)18(24-13)29-7-11-2-3-11/h6,11-12,14H,2-5,7-9H2,1H3,(H,25,28)/t14-/m1/s1
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n/an/an/an/a 40.9n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240036
PNG
(US9403808, 47)
Show SMILES FC(F)(F)[C@H](NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)c1ccccn1
Show InChI InChI=1S/C19H18F5N5O2/c20-18(21)9-29(10-18)15-17(31-8-11-4-5-11)27-13(7-26-15)16(30)28-14(19(22,23)24)12-3-1-2-6-25-12/h1-3,6-7,11,14H,4-5,8-10H2,(H,28,30)/t14-/m1/s1
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n/an/an/an/a 72.9n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240041
PNG
(US9403808, 52)
Show SMILES CC(C)[C@@](C)(CO)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C18H27N3O3/c1-11(2)18(3,10-22)21-16(23)14-8-19-15(13-6-7-13)17(20-14)24-9-12-4-5-12/h8,11-13,22H,4-7,9-10H2,1-3H3,(H,21,23)/t18-/m1/s1
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n/an/an/an/a 36.9n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240050
PNG
(US9403808, 61)
Show SMILES Cc1nc(no1)C(C)(NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)C1CC1
Show InChI InChI=1S/C20H24F2N6O3/c1-11-24-18(27-31-11)19(2,13-5-6-13)26-16(29)14-7-23-15(28-9-20(21,22)10-28)17(25-14)30-8-12-3-4-12/h7,12-13H,3-6,8-10H2,1-2H3,(H,26,29)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240051
PNG
(US9403808, 62)
Show SMILES Cc1nc(no1)C(C)(NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1)C1CC1
Show InChI InChI=1S/C20H25N5O3/c1-11-22-19(25-28-11)20(2,14-7-8-14)24-17(26)15-9-21-16(13-5-6-13)18(23-15)27-10-12-3-4-12/h9,12-14H,3-8,10H2,1-2H3,(H,24,26)
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n/an/an/an/a 22.8n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240074
PNG
(US9403808, 85)
Show SMILES NC(=O)CC1(COC1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C17H21F2N5O4/c18-17(19)6-24(7-17)13-15(28-5-10-1-2-10)22-11(4-21-13)14(26)23-16(3-12(20)25)8-27-9-16/h4,10H,1-3,5-9H2,(H2,20,25)(H,23,26)
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n/an/an/an/a 5.80n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240076
PNG
(US9403808, 87)
Show SMILES Cc1nc(no1)[C@](C)(NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)C1CC1
Show InChI InChI=1S/C20H24F2N6O3/c1-11-24-18(27-31-11)19(2,13-5-6-13)26-16(29)14-7-23-15(28-9-20(21,22)10-28)17(25-14)30-8-12-3-4-12/h7,12-13H,3-6,8-10H2,1-2H3,(H,26,29)/t19-/m1/s1
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n/an/an/an/a 13.2n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240092
PNG
(US9403808, 103)
Show SMILES CN(C)C(=O)C(CC1CCC1)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C21H30N4O3/c1-25(2)21(27)16(10-13-4-3-5-13)23-19(26)17-11-22-18(15-8-9-15)20(24-17)28-12-14-6-7-14/h11,13-16H,3-10,12H2,1-2H3,(H,23,26)
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n/an/an/an/a 19.2n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM239992
PNG
(US9403808, 3)
Show SMILES Cc1nc(no1)C1(CCC1)NC(=O)c1cnc(C2CC2)c(n1)-c1cccc(Cl)c1
Show InChI InChI=1S/C21H20ClN5O2/c1-12-24-20(27-29-12)21(8-3-9-21)26-19(28)16-11-23-17(13-6-7-13)18(25-16)14-4-2-5-15(22)10-14/h2,4-5,10-11,13H,3,6-9H2,1H3,(H,26,28)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240006
PNG
(US9403808, 17)
Show SMILES CC(C)(O)[C@H](CC1CC1)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H29N3O3/c1-20(2,25)16(9-12-3-4-12)23-18(24)15-10-21-17(14-7-8-14)19(22-15)26-11-13-5-6-13/h10,12-14,16,25H,3-9,11H2,1-2H3,(H,23,24)/t16-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240017
PNG
(US9403808, 28)
Show SMILES NC(=O)[C@H](CC1CC1)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C18H24N4O3/c19-16(23)13(7-10-1-2-10)21-17(24)14-8-20-15(12-5-6-12)18(22-14)25-9-11-3-4-11/h8,10-13H,1-7,9H2,(H2,19,23)(H,21,24)/t13-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240020
PNG
(US9403808, 31)
Show SMILES CNC(=O)[C@H](CC1CC1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H25F2N5O3/c1-22-16(27)13(6-11-2-3-11)24-17(28)14-7-23-15(26-9-19(20,21)10-26)18(25-14)29-8-12-4-5-12/h7,11-13H,2-6,8-10H2,1H3,(H,22,27)(H,24,28)/t13-/m0/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240022
PNG
(US9403808, 33)
Show SMILES CNC(=O)[C@H](CC(C)C)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H27F2N5O3/c1-11(2)6-13(16(27)22-3)24-17(28)14-7-23-15(26-9-19(20,21)10-26)18(25-14)29-8-12-4-5-12/h7,11-13H,4-6,8-10H2,1-3H3,(H,22,27)(H,24,28)/t13-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240028
PNG
(US9403808, 39)
Show SMILES NC(=O)[C@H](CC1CC1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C18H23F2N5O3/c19-18(20)8-25(9-18)15-17(28-7-11-3-4-11)24-13(6-22-15)16(27)23-12(14(21)26)5-10-1-2-10/h6,10-12H,1-5,7-9H2,(H2,21,26)(H,23,27)/t12-/m0/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240032
PNG
(US9403808, 43)
Show SMILES Cc1nc(no1)[C@H](NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)C1CC1
Show InChI InChI=1S/C19H22F2N6O3/c1-10-23-15(26-30-10)14(12-4-5-12)25-17(28)13-6-22-16(27-8-19(20,21)9-27)18(24-13)29-7-11-2-3-11/h6,11-12,14H,2-5,7-9H2,1H3,(H,25,28)/t14-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240035
PNG
(US9403808, 46)
Show SMILES C[C@H](NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1)c1ccccn1
Show InChI InChI=1S/C19H22N4O2/c1-12(15-4-2-3-9-20-15)22-18(24)16-10-21-17(14-7-8-14)19(23-16)25-11-13-5-6-13/h2-4,9-10,12-14H,5-8,11H2,1H3,(H,22,24)/t12-/m0/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240046
PNG
(US9403808, 57)
Show SMILES CC(C)(NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1)c1noc(N)n1
Show InChI InChI=1S/C17H22N6O3/c1-17(2,15-21-16(18)26-23-15)22-13(24)11-7-19-12(10-5-6-10)14(20-11)25-8-9-3-4-9/h7,9-10H,3-6,8H2,1-2H3,(H,22,24)(H2,18,21,23)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240048
PNG
(US9403808, 59)
Show SMILES C[C@@](NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)(C(N)=O)c1ccccc1
Show InChI InChI=1S/C21H23F2N5O3/c1-20(19(24)30,14-5-3-2-4-6-14)27-17(29)15-9-25-16(28-11-21(22,23)12-28)18(26-15)31-10-13-7-8-13/h2-6,9,13H,7-8,10-12H2,1H3,(H2,24,30)(H,27,29)/t20-/m0/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240076
PNG
(US9403808, 87)
Show SMILES Cc1nc(no1)[C@](C)(NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)C1CC1
Show InChI InChI=1S/C20H24F2N6O3/c1-11-24-18(27-31-11)19(2,13-5-6-13)26-16(29)14-7-23-15(28-9-20(21,22)10-28)17(25-14)30-8-12-3-4-12/h7,12-13H,3-6,8-10H2,1-2H3,(H,26,29)/t19-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240078
PNG
(US9403808, 89)
Show SMILES NC(=O)C1(CCCCC1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H25F2N5O3/c20-19(21)10-26(11-19)14-16(29-9-12-4-5-12)24-13(8-23-14)15(27)25-18(17(22)28)6-2-1-3-7-18/h8,12H,1-7,9-11H2,(H2,22,28)(H,25,27)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240087
PNG
(US9403808, 98)
Show SMILES CNC(=O)C(CC1CCC1)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H28N4O3/c1-21-18(25)15(9-12-3-2-4-12)23-19(26)16-10-22-17(14-7-8-14)20(24-16)27-11-13-5-6-13/h10,12-15H,2-9,11H2,1H3,(H,21,25)(H,23,26)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240088
PNG
(US9403808, 99)
Show SMILES COCCC(C)(C)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C18H26F2N4O3/c1-17(2,6-7-26-3)23-15(25)13-8-21-14(24-10-18(19,20)11-24)16(22-13)27-9-12-4-5-12/h8,12H,4-7,9-11H2,1-3H3,(H,23,25)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240089
PNG
(US9403808, 100)
Show SMILES OCC(CC1CCC1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H26F2N4O3/c20-19(21)10-25(11-19)16-18(28-9-13-4-5-13)24-15(7-22-16)17(27)23-14(8-26)6-12-2-1-3-12/h7,12-14,26H,1-6,8-11H2,(H,23,27)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240091
PNG
(US9403808, 102)
Show SMILES CC(C)(CCc1ccccc1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C23H28F2N4O2/c1-22(2,11-10-16-6-4-3-5-7-16)28-20(30)18-12-26-19(29-14-23(24,25)15-29)21(27-18)31-13-17-8-9-17/h3-7,12,17H,8-11,13-15H2,1-2H3,(H,28,30)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240096
PNG
(US9403808, 107)
Show SMILES CC(C)(CC(N)=O)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C17H23F2N5O3/c1-16(2,5-12(20)25)23-14(26)11-6-21-13(24-8-17(18,19)9-24)15(22-11)27-7-10-3-4-10/h6,10H,3-5,7-9H2,1-2H3,(H2,20,25)(H,23,26)
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n/an/an/an/a 874n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM239999
PNG
(US9403808, 10)
Show SMILES CC(C)(CCO)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C17H25N3O3/c1-17(2,7-8-21)20-15(22)13-9-18-14(12-5-6-12)16(19-13)23-10-11-3-4-11/h9,11-12,21H,3-8,10H2,1-2H3,(H,20,22)
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n/an/an/an/a 257n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240012
PNG
(US9403808, 23)
Show SMILES COC(=O)[C@@H](NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1)C(C)(C)C
Show InChI InChI=1S/C19H27N3O4/c1-19(2,3)15(18(24)25-4)22-16(23)13-9-20-14(12-7-8-12)17(21-13)26-10-11-5-6-11/h9,11-12,15H,5-8,10H2,1-4H3,(H,22,23)/t15-/m1/s1
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n/an/an/an/a 1.70n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240021
PNG
(US9403808, 32)
Show SMILES CN(C)C(=O)[C@H](CC1CC1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H27F2N5O3/c1-26(2)19(29)14(7-12-3-4-12)24-17(28)15-8-23-16(27-10-20(21,22)11-27)18(25-15)30-9-13-5-6-13/h8,12-14H,3-7,9-11H2,1-2H3,(H,24,28)/t14-/m0/s1
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n/an/an/an/a 59.6n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240031
PNG
(US9403808, 42)
Show SMILES Cc1nc(no1)[C@@H](NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)C1CC1
Show InChI InChI=1S/C19H22F2N6O3/c1-10-23-15(26-30-10)14(12-4-5-12)25-17(28)13-6-22-16(27-8-19(20,21)9-27)18(24-13)29-7-11-2-3-11/h6,11-12,14H,2-5,7-9H2,1H3,(H,25,28)/t14-/m0/s1
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n/an/an/an/a 28n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240035
PNG
(US9403808, 46)
Show SMILES C[C@H](NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1)c1ccccn1
Show InChI InChI=1S/C19H22N4O2/c1-12(15-4-2-3-9-20-15)22-18(24)16-10-21-17(14-7-8-14)19(23-16)25-11-13-5-6-13/h2-4,9-10,12-14H,5-8,11H2,1H3,(H,22,24)/t12-/m0/s1
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n/an/an/an/a 291n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240042
PNG
(US9403808, 53)
Show SMILES CCC(CC)(NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1)C(=O)NC
Show InChI InChI=1S/C19H28N4O3/c1-4-19(5-2,18(25)20-3)23-16(24)14-10-21-15(13-8-9-13)17(22-14)26-11-12-6-7-12/h10,12-13H,4-9,11H2,1-3H3,(H,20,25)(H,23,24)
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n/an/an/an/a 15.1n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240044
PNG
(US9403808, 55 | US9403808, 75)
Show SMILES Cc1csc(n1)C(C)(C)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H23F2N5O2S/c1-11-8-29-17(23-11)18(2,3)25-15(27)13-6-22-14(26-9-19(20,21)10-26)16(24-13)28-7-12-4-5-12/h6,8,12H,4-5,7,9-10H2,1-3H3,(H,25,27)
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n/an/an/an/a 22n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240047
PNG
(US9403808, 58)
Show SMILES CC(C)(NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)c1noc(N)n1
Show InChI InChI=1S/C17H21F2N7O3/c1-16(2,14-23-15(20)29-25-14)24-12(27)10-5-21-11(26-7-17(18,19)8-26)13(22-10)28-6-9-3-4-9/h5,9H,3-4,6-8H2,1-2H3,(H,24,27)(H2,20,23,25)
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n/an/an/an/a 178n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240055
PNG
(US9403808, 66)
Show SMILES COC(=O)[C@H](CC(C)C)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H26F2N4O4/c1-11(2)6-13(18(27)28-3)23-16(26)14-7-22-15(25-9-19(20,21)10-25)17(24-14)29-8-12-4-5-12/h7,11-13H,4-6,8-10H2,1-3H3,(H,23,26)/t13-/m0/s1
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n/an/an/an/a 0.400n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240058
PNG
(US9403808, 69)
Show SMILES CC(C)(CCCO)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C18H27N3O3/c1-18(2,8-3-9-22)21-16(23)14-10-19-15(13-6-7-13)17(20-14)24-11-12-4-5-12/h10,12-13,22H,3-9,11H2,1-2H3,(H,21,23)
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n/an/an/an/a 47.4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240071
PNG
(US9403808, 82)
Show SMILES NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H26N4O3/c20-17(24)13-3-1-2-4-14(13)22-18(25)15-9-21-16(12-7-8-12)19(23-15)26-10-11-5-6-11/h9,11-14H,1-8,10H2,(H2,20,24)(H,22,25)/t13-,14+/m1/s1
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n/an/an/an/a 257n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240082
PNG
(US9403808, 93)
Show SMILES FC1(F)CN(C1)c1ncc(nc1OCC1CC1)C(=O)Nc1ccc(Cl)s1
Show InChI InChI=1S/C16H15ClF2N4O2S/c17-11-3-4-12(26-11)22-14(24)10-5-20-13(23-7-16(18,19)8-23)15(21-10)25-6-9-1-2-9/h3-5,9H,1-2,6-8H2,(H,22,24)
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n/an/an/an/a 74.1n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240096
PNG
(US9403808, 107)
Show SMILES CC(C)(CC(N)=O)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C17H23F2N5O3/c1-16(2,5-12(20)25)23-14(26)11-6-21-13(24-8-17(18,19)9-24)15(22-11)27-7-10-3-4-10/h6,10H,3-5,7-9H2,1-2H3,(H2,20,25)(H,23,26)
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n/an/an/an/a 11.8n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM239990
PNG
(US9403808, 1)
Show SMILES Cc1nc(no1)C(C)(C)NC(=O)c1cnc(C2CC2)c(n1)-c1cccc(Cl)c1
Show InChI InChI=1S/C20H20ClN5O2/c1-11-23-19(26-28-11)20(2,3)25-18(27)15-10-22-16(12-7-8-12)17(24-15)13-5-4-6-14(21)9-13/h4-6,9-10,12H,7-8H2,1-3H3,(H,25,27)
PDB

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n/an/an/an/a 1.15E+3n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM239995
PNG
(US9403808, 6)
Show SMILES CC(C)(NC(=O)c1cnc(C2CC2)c(n1)-c1cccc(Cl)c1)c1nccs1
Show InChI InChI=1S/C20H19ClN4OS/c1-20(2,19-22-8-9-27-19)25-18(26)15-11-23-16(12-6-7-12)17(24-15)13-4-3-5-14(21)10-13/h3-5,8-12H,6-7H2,1-2H3,(H,25,26)
PDB

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n/an/an/an/a 892n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM239996
PNG
(US9403808, 7)
Show SMILES Clc1cccc(c1)-c1nc(cnc1C1CC1)C(=O)NN1CCCCC1
Show InChI InChI=1S/C19H21ClN4O/c20-15-6-4-5-14(11-15)18-17(13-7-8-13)21-12-16(22-18)19(25)23-24-9-2-1-3-10-24/h4-6,11-13H,1-3,7-10H2,(H,23,25)
PDB

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n/an/an/an/a>1.00E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240004
PNG
(US9403808, 15)
Show SMILES NC(=O)[C@@H](NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1)c1ccccc1
Show InChI InChI=1S/C20H22N4O3/c21-18(25)16(13-4-2-1-3-5-13)24-19(26)15-10-22-17(14-8-9-14)20(23-15)27-11-12-6-7-12/h1-5,10,12,14,16H,6-9,11H2,(H2,21,25)(H,24,26)/t16-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240005
PNG
(US9403808, 16)
Show SMILES CC(C)(O)[C@H](CC1CC1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H28F2N4O3/c1-19(2,28)15(7-12-3-4-12)25-17(27)14-8-23-16(26-10-20(21,22)11-26)18(24-14)29-9-13-5-6-13/h8,12-13,15,28H,3-7,9-11H2,1-2H3,(H,25,27)/t15-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240010
PNG
(US9403808, 21)
Show SMILES OCC(NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)C1CC1
Show InChI InChI=1S/C17H22F2N4O3/c18-17(19)8-23(9-17)14-16(26-7-10-1-2-10)22-12(5-20-14)15(25)21-13(6-24)11-3-4-11/h5,10-11,13,24H,1-4,6-9H2,(H,21,25)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240014
PNG
(US9403808, 25)
Show SMILES CN(C)C(=O)[C@H](CC1CC1)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H28N4O3/c1-24(2)20(26)15(9-12-3-4-12)22-18(25)16-10-21-17(14-7-8-14)19(23-16)27-11-13-5-6-13/h10,12-15H,3-9,11H2,1-2H3,(H,22,25)/t15-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240038
PNG
(US9403808, 49)
Show SMILES FC(F)(F)[C@@H](NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1)c1ccccn1
Show InChI InChI=1S/C19H19F3N4O2/c20-19(21,22)16(13-3-1-2-8-23-13)26-17(27)14-9-24-15(12-6-7-12)18(25-14)28-10-11-4-5-11/h1-3,8-9,11-12,16H,4-7,10H2,(H,26,27)/t16-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240043
PNG
(US9403808, 54 | US9403808, 74)
Show SMILES Cc1csc(n1)C(C)(C)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H24N4O2S/c1-11-10-26-18(21-11)19(2,3)23-16(24)14-8-20-15(13-6-7-13)17(22-14)25-9-12-4-5-12/h8,10,12-13H,4-7,9H2,1-3H3,(H,23,24)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240077
PNG
(US9403808, 88)
Show SMILES CC(C)C(NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(N)=O
Show InChI InChI=1S/C17H23F2N5O3/c1-9(2)12(13(20)25)23-15(26)11-5-21-14(24-7-17(18,19)8-24)16(22-11)27-6-10-3-4-10/h5,9-10,12H,3-4,6-8H2,1-2H3,(H2,20,25)(H,23,26)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240085
PNG
(US9403808, 96)
Show SMILES CNC(=O)C(CC1CCC1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H27F2N5O3/c1-23-17(28)14(7-12-3-2-4-12)25-18(29)15-8-24-16(27-10-20(21,22)11-27)19(26-15)30-9-13-5-6-13/h8,12-14H,2-7,9-11H2,1H3,(H,23,28)(H,25,29)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240095
PNG
(US9403808, 106)
Show SMILES CC(C)(CC(N)=O)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C17H24N4O3/c1-17(2,7-13(18)22)21-15(23)12-8-19-14(11-5-6-11)16(20-12)24-9-10-3-4-10/h8,10-11H,3-7,9H2,1-2H3,(H2,18,22)(H,21,23)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM239992
PNG
(US9403808, 3)
Show SMILES Cc1nc(no1)C1(CCC1)NC(=O)c1cnc(C2CC2)c(n1)-c1cccc(Cl)c1
Show InChI InChI=1S/C21H20ClN5O2/c1-12-24-20(27-29-12)21(8-3-9-21)26-19(28)16-11-23-17(13-6-7-13)18(25-16)14-4-2-5-15(22)10-14/h2,4-5,10-11,13H,3,6-9H2,1H3,(H,26,28)
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n/an/an/an/a 156n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM239993
PNG
(US9403808, 4)
Show SMILES Cc1nc(no1)C(C)(C)NC(=O)c1cnc(N2CC(F)(F)C2)c(n1)-c1cccc(Cl)c1
Show InChI InChI=1S/C20H19ClF2N6O2/c1-11-25-18(28-31-11)19(2,3)27-17(30)14-8-24-16(29-9-20(22,23)10-29)15(26-14)12-5-4-6-13(21)7-12/h4-8H,9-10H2,1-3H3,(H,27,30)
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n/an/an/an/a 108n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240003
PNG
(US9403808, 14)
Show SMILES CNC(=O)[C@@H](NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1)C(C)(C)C
Show InChI InChI=1S/C19H28N4O3/c1-19(2,3)15(17(25)20-4)23-16(24)13-9-21-14(12-7-8-12)18(22-13)26-10-11-5-6-11/h9,11-12,15H,5-8,10H2,1-4H3,(H,20,25)(H,23,24)/t15-/m1/s1
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n/an/an/an/a 6.80n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240017
PNG
(US9403808, 28)
Show SMILES NC(=O)[C@H](CC1CC1)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C18H24N4O3/c19-16(23)13(7-10-1-2-10)21-17(24)14-8-20-15(12-5-6-12)18(22-14)25-9-11-3-4-11/h8,10-13H,1-7,9H2,(H2,19,23)(H,21,24)/t13-/m0/s1
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n/an/an/an/a 43.5n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240023
PNG
(US9403808, 34)
Show SMILES CC(C)C[C@H](NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(=O)N(C)C
Show InChI InChI=1S/C20H29F2N5O3/c1-12(2)7-14(19(29)26(3)4)24-17(28)15-8-23-16(27-10-20(21,22)11-27)18(25-15)30-9-13-5-6-13/h8,12-14H,5-7,9-11H2,1-4H3,(H,24,28)/t14-/m0/s1
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n/an/an/an/a 13.6n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240028
PNG
(US9403808, 39)
Show SMILES NC(=O)[C@H](CC1CC1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C18H23F2N5O3/c19-18(20)8-25(9-18)15-17(28-7-11-3-4-11)24-13(6-22-15)16(27)23-12(14(21)26)5-10-1-2-10/h6,10-12H,1-5,7-9H2,(H2,21,26)(H,23,27)/t12-/m0/s1
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n/an/an/an/a 11n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240029
PNG
(US9403808, 40)
Show SMILES Cc1nc(no1)[C@@H](NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1)C1CC1
Show InChI InChI=1S/C19H23N5O3/c1-10-21-17(24-27-10)15(12-4-5-12)23-18(25)14-8-20-16(13-6-7-13)19(22-14)26-9-11-2-3-11/h8,11-13,15H,2-7,9H2,1H3,(H,23,25)/t15-/m0/s1
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n/an/an/an/a 30.8n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240033
PNG
(US9403808, 44)
Show SMILES CC(C)(C)[C@H](NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1)C(O)=O
Show InChI InChI=1S/C18H25N3O4/c1-18(2,3)14(17(23)24)21-15(22)12-8-19-13(11-6-7-11)16(20-12)25-9-10-4-5-10/h8,10-11,14H,4-7,9H2,1-3H3,(H,21,22)(H,23,24)/t14-/m1/s1
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n/an/an/an/a 442n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240040
PNG
(US9403808, 51)
Show SMILES CC(C)[C@](C)(CO)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C18H27N3O3/c1-11(2)18(3,10-22)21-16(23)14-8-19-15(13-6-7-13)17(20-14)24-9-12-4-5-12/h8,11-13,22H,4-7,9-10H2,1-3H3,(H,21,23)/t18-/m0/s1
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n/an/an/an/a 137n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240060
PNG
(US9403808, 71)
Show SMILES Cc1oc(nc1CC(C)(C)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1)-c1ccccc1
Show InChI InChI=1S/C26H30N4O3/c1-16-20(28-24(33-16)19-7-5-4-6-8-19)13-26(2,3)30-23(31)21-14-27-22(18-11-12-18)25(29-21)32-15-17-9-10-17/h4-8,14,17-18H,9-13,15H2,1-3H3,(H,30,31)
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n/an/an/an/a 201n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240072
PNG
(US9403808, 83)
Show SMILES NC(=O)[C@H]1CCCC[C@H]1NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H26N4O3/c20-17(24)13-3-1-2-4-14(13)22-18(25)15-9-21-16(12-7-8-12)19(23-15)26-10-11-5-6-11/h9,11-14H,1-8,10H2,(H2,20,24)(H,22,25)/t13-,14+/m0/s1
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n/an/an/an/a 44.4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240075
PNG
(US9403808, 86)
Show SMILES Cc1nc(no1)[C@@](C)(NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)C1CC1
Show InChI InChI=1S/C20H24F2N6O3/c1-11-24-18(27-31-11)19(2,13-5-6-13)26-16(29)14-7-23-15(28-9-20(21,22)10-28)17(25-14)30-8-12-3-4-12/h7,12-13H,3-6,8-10H2,1-2H3,(H,26,29)/t19-/m0/s1
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n/an/an/an/a 23.7n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240079
PNG
(US9403808, 90)
Show SMILES OCC1(CCCCC1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H26F2N4O3/c20-19(21)10-25(11-19)15-17(28-9-13-4-5-13)23-14(8-22-15)16(27)24-18(12-26)6-2-1-3-7-18/h8,13,26H,1-7,9-12H2,(H,24,27)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240081
PNG
(US9403808, 92)
Show SMILES CC(C)C(NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1)C(=O)N(C)C
Show InChI InChI=1S/C19H28N4O3/c1-11(2)15(19(25)23(3)4)22-17(24)14-9-20-16(13-7-8-13)18(21-14)26-10-12-5-6-12/h9,11-13,15H,5-8,10H2,1-4H3,(H,22,24)
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n/an/an/an/a 8.60n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240083
PNG
(US9403808, 94)
Show SMILES OCC1(CCCCC1)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H27N3O3/c23-12-19(8-2-1-3-9-19)22-17(24)15-10-20-16(14-6-7-14)18(21-15)25-11-13-4-5-13/h10,13-14,23H,1-9,11-12H2,(H,22,24)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240093
PNG
(US9403808, 104)
Show SMILES NC(=O)C(CC1CCC1)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H26N4O3/c20-17(24)14(8-11-2-1-3-11)22-18(25)15-9-21-16(13-6-7-13)19(23-15)26-10-12-4-5-12/h9,11-14H,1-8,10H2,(H2,20,24)(H,22,25)
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n/an/an/an/a 42.9n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM239997
PNG
(US9403808, 8)
Show SMILES CNC(=O)[C@@H](NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(C)(C)C
Show InChI InChI=1S/C19H27F2N5O3/c1-18(2,3)13(16(28)22-4)25-15(27)12-7-23-14(26-9-19(20,21)10-26)17(24-12)29-8-11-5-6-11/h7,11,13H,5-6,8-10H2,1-4H3,(H,22,28)(H,25,27)/t13-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM239999
PNG
(US9403808, 10)
Show SMILES CC(C)(CCO)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C17H25N3O3/c1-17(2,7-8-21)20-15(22)13-9-18-14(12-5-6-12)16(19-13)23-10-11-3-4-11/h9,11-12,21H,3-8,10H2,1-2H3,(H,20,22)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240003
PNG
(US9403808, 14)
Show SMILES CNC(=O)[C@@H](NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1)C(C)(C)C
Show InChI InChI=1S/C19H28N4O3/c1-19(2,3)15(17(25)20-4)23-16(24)13-9-21-14(12-7-8-12)18(22-13)26-10-11-5-6-11/h9,11-12,15H,5-8,10H2,1-4H3,(H,20,25)(H,23,24)/t15-/m1/s1
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n/an/an/an/a 155n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240013
PNG
(US9403808, 24)
Show SMILES CNC(=O)[C@H](CC1CC1)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H26N4O3/c1-20-17(24)14(8-11-2-3-11)22-18(25)15-9-21-16(13-6-7-13)19(23-15)26-10-12-4-5-12/h9,11-14H,2-8,10H2,1H3,(H,20,24)(H,22,25)/t14-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240026
PNG
(US9403808, 37)
Show SMILES NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C21H24N4O3/c22-19(26)16(10-13-4-2-1-3-5-13)24-20(27)17-11-23-18(15-8-9-15)21(25-17)28-12-14-6-7-14/h1-5,11,14-16H,6-10,12H2,(H2,22,26)(H,24,27)/t16-/m0/s1
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n/an/an/an/a 1.64E+3n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240027
PNG
(US9403808, 38)
Show SMILES NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C21H23F2N5O3/c22-21(23)11-28(12-21)18-20(31-10-14-6-7-14)27-16(9-25-18)19(30)26-15(17(24)29)8-13-4-2-1-3-5-13/h1-5,9,14-15H,6-8,10-12H2,(H2,24,29)(H,26,30)/t15-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240037
PNG
(US9403808, 48)
Show SMILES FC(F)(F)[C@@H](NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)c1ccccn1
Show InChI InChI=1S/C19H18F5N5O2/c20-18(21)9-29(10-18)15-17(31-8-11-4-5-11)27-13(7-26-15)16(30)28-14(19(22,23)24)12-3-1-2-6-25-12/h1-3,6-7,11,14H,4-5,8-10H2,(H,28,30)/t14-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240040
PNG
(US9403808, 51)
Show SMILES CC(C)[C@](C)(CO)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C18H27N3O3/c1-11(2)18(3,10-22)21-16(23)14-8-19-15(13-6-7-13)17(20-14)24-9-12-4-5-12/h8,11-13,22H,4-7,9-10H2,1-3H3,(H,21,23)/t18-/m0/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240041
PNG
(US9403808, 52)
Show SMILES CC(C)[C@@](C)(CO)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C18H27N3O3/c1-11(2)18(3,10-22)21-16(23)14-8-19-15(13-6-7-13)17(20-14)24-9-12-4-5-12/h8,11-13,22H,4-7,9-10H2,1-3H3,(H,21,23)/t18-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240044
PNG
(US9403808, 55 | US9403808, 75)
Show SMILES Cc1csc(n1)C(C)(C)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H23F2N5O2S/c1-11-8-29-17(23-11)18(2,3)25-15(27)13-6-22-14(26-9-19(20,21)10-26)16(24-13)28-7-12-4-5-12/h6,8,12H,4-5,7,9-10H2,1-3H3,(H,25,27)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240073
PNG
(US9403808, 84)
Show SMILES NC(=O)CC1(COC1)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C17H22N4O4/c18-13(22)5-17(8-24-9-17)21-15(23)12-6-19-14(11-3-4-11)16(20-12)25-7-10-1-2-10/h6,10-11H,1-5,7-9H2,(H2,18,22)(H,21,23)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240082
PNG
(US9403808, 93)
Show SMILES FC1(F)CN(C1)c1ncc(nc1OCC1CC1)C(=O)Nc1ccc(Cl)s1
Show InChI InChI=1S/C16H15ClF2N4O2S/c17-11-3-4-12(26-11)22-14(24)10-5-20-13(23-7-16(18,19)8-23)15(21-10)25-6-9-1-2-9/h3-5,9H,1-2,6-8H2,(H,22,24)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240000
PNG
(US9403808, 11)
Show SMILES OCC1(CCC1)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C17H23N3O3/c21-10-17(6-1-7-17)20-15(22)13-8-18-14(12-4-5-12)16(19-13)23-9-11-2-3-11/h8,11-12,21H,1-7,9-10H2,(H,20,22)
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n/an/an/an/a 124n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240001
PNG
(US9403808, 12)
Show SMILES Cc1nc(no1)C1(CCC1)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H23N5O3/c1-11-21-18(24-27-11)19(7-2-8-19)23-16(25)14-9-20-15(13-5-6-13)17(22-14)26-10-12-3-4-12/h9,12-13H,2-8,10H2,1H3,(H,23,25)
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n/an/an/an/a 85.2n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240018
PNG
(US9403808, 29)
Show SMILES CC(C)C[C@H](NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1)C(N)=O
Show InChI InChI=1S/C18H26N4O3/c1-10(2)7-13(16(19)23)21-17(24)14-8-20-15(12-5-6-12)18(22-14)25-9-11-3-4-11/h8,10-13H,3-7,9H2,1-2H3,(H2,19,23)(H,21,24)/t13-/m0/s1
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n/an/an/an/a 4.10n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240019
PNG
(US9403808, 30)
Show SMILES CCC(CC)(NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1)C(=O)OC
Show InChI InChI=1S/C19H27N3O4/c1-4-19(5-2,18(24)25-3)22-16(23)14-10-20-15(13-8-9-13)17(21-14)26-11-12-6-7-12/h10,12-13H,4-9,11H2,1-3H3,(H,22,23)
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n/an/an/an/a 1.40n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240039
PNG
(US9403808, 50)
Show SMILES CCC(CC)(NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(=O)NC
Show InChI InChI=1S/C19H27F2N5O3/c1-4-18(5-2,17(28)22-3)25-15(27)13-8-23-14(26-10-19(20,21)11-26)16(24-13)29-9-12-6-7-12/h8,12H,4-7,9-11H2,1-3H3,(H,22,28)(H,25,27)
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n/an/an/an/a 7.40n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240049
PNG
(US9403808, 60)
Show SMILES Cc1nc(no1)C(C)(CC1CC1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C21H26F2N6O3/c1-12-25-19(28-32-12)20(2,7-13-3-4-13)27-17(30)15-8-24-16(29-10-21(22,23)11-29)18(26-15)31-9-14-5-6-14/h8,13-14H,3-7,9-11H2,1-2H3,(H,27,30)
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n/an/an/an/a 14.6n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240052
PNG
(US9403808, 63)
Show SMILES NC(=O)[C@@H](NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1)c1ccc(F)cc1
Show InChI InChI=1S/C20H21FN4O3/c21-14-7-5-12(6-8-14)16(18(22)26)25-19(27)15-9-23-17(13-3-4-13)20(24-15)28-10-11-1-2-11/h5-9,11,13,16H,1-4,10H2,(H2,22,26)(H,25,27)/t16-/m0/s1
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n/an/an/an/a 96.6n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240053
PNG
(US9403808, 64)
Show SMILES NC(=O)[C@@H](NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)c1ccc(F)cc1
Show InChI InChI=1S/C20H20F3N5O3/c21-13-5-3-12(4-6-13)15(16(24)29)27-18(30)14-7-25-17(28-9-20(22,23)10-28)19(26-14)31-8-11-1-2-11/h3-7,11,15H,1-2,8-10H2,(H2,24,29)(H,27,30)/t15-/m0/s1
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n/an/an/an/a 31.2n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240056
PNG
(US9403808, 67)
Show SMILES CC(C)C[C@H](NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C20H26F5N5O3/c1-11(2)5-13(16(31)27-8-20(23,24)25)28-17(32)14-6-26-15(30-9-19(21,22)10-30)18(29-14)33-7-12-3-4-12/h6,11-13H,3-5,7-10H2,1-2H3,(H,27,31)(H,28,32)/t13-/m0/s1
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n/an/an/an/a 57.6n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240061
PNG
(US9403808, 72)
Show SMILES CC(CC(C)(C)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1)c1ccncc1
Show InChI InChI=1S/C23H30N4O2/c1-15(17-8-10-24-11-9-17)12-23(2,3)27-21(28)19-13-25-20(18-6-7-18)22(26-19)29-14-16-4-5-16/h8-11,13,15-16,18H,4-7,12,14H2,1-3H3,(H,27,28)
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n/an/an/an/a 92.6n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240062
PNG
(US9403808, 73)
Show SMILES COC(=O)C1(CCC1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C18H22F2N4O4/c1-27-16(26)17(5-2-6-17)23-14(25)12-7-21-13(24-9-18(19,20)10-24)15(22-12)28-8-11-3-4-11/h7,11H,2-6,8-10H2,1H3,(H,23,25)
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n/an/an/an/a 20.5n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240066
PNG
(US9403808, 77)
Show SMILES CC(C)[C@H](CC(N)=O)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C18H25F2N5O3/c1-10(2)12(5-14(21)26)23-16(27)13-6-22-15(25-8-18(19,20)9-25)17(24-13)28-7-11-3-4-11/h6,10-12H,3-5,7-9H2,1-2H3,(H2,21,26)(H,23,27)/t12-/m0/s1
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n/an/an/an/a 6.5n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240067
PNG
(US9403808, 78)
Show SMILES Cc1nc(no1)[C@](C)(CC1CC1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C21H26F2N6O3/c1-12-25-19(28-32-12)20(2,7-13-3-4-13)27-17(30)15-8-24-16(29-10-21(22,23)11-29)18(26-15)31-9-14-5-6-14/h8,13-14H,3-7,9-11H2,1-2H3,(H,27,30)/t20-/m0/s1
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n/an/an/an/a 17.4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240069
PNG
(US9403808, 80)
Show SMILES COC(=O)C(C)(NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)C1CC1
Show InChI InChI=1S/C19H24F2N4O4/c1-18(12-5-6-12,17(27)28-2)24-15(26)13-7-22-14(25-9-19(20,21)10-25)16(23-13)29-8-11-3-4-11/h7,11-12H,3-6,8-10H2,1-2H3,(H,24,26)
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n/an/an/an/a 0.700n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240070
PNG
(US9403808, 81)
Show SMILES NC(=O)[C@H]1CCCC[C@H]1NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H25F2N5O3/c20-19(21)9-26(10-19)16-18(29-8-11-5-6-11)25-14(7-23-16)17(28)24-13-4-2-1-3-12(13)15(22)27/h7,11-13H,1-6,8-10H2,(H2,22,27)(H,24,28)/t12-,13+/m0/s1
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n/an/an/an/a 31.2n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240078
PNG
(US9403808, 89)
Show SMILES NC(=O)C1(CCCCC1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H25F2N5O3/c20-19(21)10-26(11-19)14-16(29-9-12-4-5-12)24-13(8-23-14)15(27)25-18(17(22)28)6-2-1-3-7-18/h8,12H,1-7,9-11H2,(H2,22,28)(H,25,27)
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n/an/an/an/a 70.6n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240084
PNG
(US9403808, 95)
Show SMILES COCCC(C)(C)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C18H27N3O3/c1-18(2,8-9-23-3)21-16(22)14-10-19-15(13-6-7-13)17(20-14)24-11-12-4-5-12/h10,12-13H,4-9,11H2,1-3H3,(H,21,22)
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n/an/an/an/a 22.4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240085
PNG
(US9403808, 96)
Show SMILES CNC(=O)C(CC1CCC1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H27F2N5O3/c1-23-17(28)14(7-12-3-2-4-12)25-18(29)15-8-24-16(27-10-20(21,22)11-27)19(26-15)30-9-13-5-6-13/h8,12-14H,2-7,9-11H2,1H3,(H,23,28)(H,25,29)
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n/an/an/an/a 51.7n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240091
PNG
(US9403808, 102)
Show SMILES CC(C)(CCc1ccccc1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C23H28F2N4O2/c1-22(2,11-10-16-6-4-3-5-7-16)28-20(30)18-12-26-19(29-14-23(24,25)15-29)21(27-18)31-13-17-8-9-17/h3-7,12,17H,8-11,13-15H2,1-2H3,(H,28,30)
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n/an/an/an/a 2.5n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240001
PNG
(US9403808, 12)
Show SMILES Cc1nc(no1)C1(CCC1)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H23N5O3/c1-11-21-18(24-27-11)19(7-2-8-19)23-16(25)14-9-20-15(13-5-6-13)17(22-14)26-10-12-3-4-12/h9,12-13H,2-8,10H2,1H3,(H,23,25)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240026
PNG
(US9403808, 37)
Show SMILES NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C21H24N4O3/c22-19(26)16(10-13-4-2-1-3-5-13)24-20(27)17-11-23-18(15-8-9-15)21(25-17)28-12-14-6-7-14/h1-5,11,14-16H,6-10,12H2,(H2,22,26)(H,24,27)/t16-/m0/s1
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n/an/an/an/a 108n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240018
PNG
(US9403808, 29)
Show SMILES CC(C)C[C@H](NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1)C(N)=O
Show InChI InChI=1S/C18H26N4O3/c1-10(2)7-13(16(19)23)21-17(24)14-8-20-15(12-5-6-12)18(22-14)25-9-11-3-4-11/h8,10-13H,3-7,9H2,1-2H3,(H2,19,23)(H,21,24)/t13-/m0/s1
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n/an/an/an/a 1.57E+3n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240021
PNG
(US9403808, 32)
Show SMILES CN(C)C(=O)[C@H](CC1CC1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H27F2N5O3/c1-26(2)19(29)14(7-12-3-4-12)24-17(28)15-8-23-16(27-10-20(21,22)11-27)18(25-15)30-9-13-5-6-13/h8,12-14H,3-7,9-11H2,1-2H3,(H,24,28)/t14-/m0/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240030
PNG
(US9403808, 41)
Show SMILES Cc1nc(no1)[C@H](NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1)C1CC1
Show InChI InChI=1S/C19H23N5O3/c1-10-21-17(24-27-10)15(12-4-5-12)23-18(25)14-8-20-16(13-6-7-13)19(22-14)26-9-11-2-3-11/h8,11-13,15H,2-7,9H2,1H3,(H,23,25)/t15-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240047
PNG
(US9403808, 58)
Show SMILES CC(C)(NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)c1noc(N)n1
Show InChI InChI=1S/C17H21F2N7O3/c1-16(2,14-23-15(20)29-25-14)24-12(27)10-5-21-11(26-7-17(18,19)8-26)13(22-10)28-6-9-3-4-9/h5,9H,3-4,6-8H2,1-2H3,(H,24,27)(H2,20,23,25)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240049
PNG
(US9403808, 60)
Show SMILES Cc1nc(no1)C(C)(CC1CC1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C21H26F2N6O3/c1-12-25-19(28-32-12)20(2,7-13-3-4-13)27-17(30)15-8-24-16(29-10-21(22,23)11-29)18(26-15)31-9-14-5-6-14/h8,13-14H,3-7,9-11H2,1-2H3,(H,27,30)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240079
PNG
(US9403808, 90)
Show SMILES OCC1(CCCCC1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H26F2N4O3/c20-19(21)10-25(11-19)15-17(28-9-13-4-5-13)23-14(8-22-15)16(27)24-18(12-26)6-2-1-3-7-18/h8,13,26H,1-7,9-12H2,(H,24,27)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240081
PNG
(US9403808, 92)
Show SMILES CC(C)C(NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1)C(=O)N(C)C
Show InChI InChI=1S/C19H28N4O3/c1-11(2)15(19(25)23(3)4)22-17(24)14-9-20-16(13-7-8-13)18(21-14)26-10-12-5-6-12/h9,11-13,15H,5-8,10H2,1-4H3,(H,22,24)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240086
PNG
(US9403808, 97)
Show SMILES CN(C)C(=O)C(CC1CCC1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C21H29F2N5O3/c1-27(2)20(30)15(8-13-4-3-5-13)25-18(29)16-9-24-17(28-11-21(22,23)12-28)19(26-16)31-10-14-6-7-14/h9,13-15H,3-8,10-12H2,1-2H3,(H,25,29)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240024
PNG
(US9403808, 35)
Show SMILES COC(=O)[C@H](CC1CC1)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H25N3O4/c1-25-19(24)14(8-11-2-3-11)21-17(23)15-9-20-16(13-6-7-13)18(22-15)26-10-12-4-5-12/h9,11-14H,2-8,10H2,1H3,(H,21,23)/t14-/m0/s1
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n/an/an/an/a 43.3n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240025
PNG
(US9403808, 36)
Show SMILES COC(=O)[C@H](CC1CC1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H24F2N4O4/c1-28-18(27)13(6-11-2-3-11)23-16(26)14-7-22-15(25-9-19(20,21)10-25)17(24-14)29-8-12-4-5-12/h7,11-13H,2-6,8-10H2,1H3,(H,23,26)/t13-/m0/s1
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n/an/an/an/a 9.60n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240027
PNG
(US9403808, 38)
Show SMILES NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C21H23F2N5O3/c22-21(23)11-28(12-21)18-20(31-10-14-6-7-14)27-16(9-25-18)19(30)26-15(17(24)29)8-13-4-2-1-3-5-13/h1-5,9,14-15H,6-8,10-12H2,(H2,24,29)(H,26,30)/t15-/m0/s1
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n/an/an/an/a 44.4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240046
PNG
(US9403808, 57)
Show SMILES CC(C)(NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1)c1noc(N)n1
Show InChI InChI=1S/C17H22N6O3/c1-17(2,15-21-16(18)26-23-15)22-13(24)11-7-19-12(10-5-6-10)14(20-11)25-8-9-3-4-9/h7,9-10H,3-6,8H2,1-2H3,(H,22,24)(H2,18,21,23)
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n/an/an/an/a 221n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240068
PNG
(US9403808, 79)
Show SMILES Cc1nc(no1)[C@@](C)(CC1CC1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C21H26F2N6O3/c1-12-25-19(28-32-12)20(2,7-13-3-4-13)27-17(30)15-8-24-16(29-10-21(22,23)11-29)18(26-15)31-9-14-5-6-14/h8,13-14H,3-7,9-11H2,1-2H3,(H,27,30)/t20-/m1/s1
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n/an/an/an/a 4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240086
PNG
(US9403808, 97)
Show SMILES CN(C)C(=O)C(CC1CCC1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C21H29F2N5O3/c1-27(2)20(30)15(8-13-4-3-5-13)25-18(29)16-9-24-17(28-11-21(22,23)12-28)19(26-16)31-10-14-6-7-14/h9,13-15H,3-8,10-12H2,1-2H3,(H,25,29)
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n/an/an/an/a 20.4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240094
PNG
(US9403808, 105)
Show SMILES OCC(CC1CCC1)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H27N3O3/c23-10-15(8-12-2-1-3-12)21-18(24)16-9-20-17(14-6-7-14)19(22-16)25-11-13-4-5-13/h9,12-15,23H,1-8,10-11H2,(H,21,24)
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n/an/an/an/a 37n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240000
PNG
(US9403808, 11)
Show SMILES OCC1(CCC1)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C17H23N3O3/c21-10-17(6-1-7-17)20-15(22)13-8-18-14(12-4-5-12)16(19-13)23-9-11-2-3-11/h8,11-12,21H,1-7,9-10H2,(H,20,22)
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n/an/an/an/a 3.32E+3n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240007
PNG
(US9403808, 18)
Show SMILES O=C(NN1CCCCC1)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C17H24N4O2/c22-16(20-21-8-2-1-3-9-21)14-10-18-15(13-6-7-13)17(19-14)23-11-12-4-5-12/h10,12-13H,1-9,11H2,(H,20,22)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240011
PNG
(US9403808, 22)
Show SMILES NC(=O)[C@@H](NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)c1ccccc1
Show InChI InChI=1S/C20H21F2N5O3/c21-20(22)10-27(11-20)17-19(30-9-12-6-7-12)25-14(8-24-17)18(29)26-15(16(23)28)13-4-2-1-3-5-13/h1-5,8,12,15H,6-7,9-11H2,(H2,23,28)(H,26,29)/t15-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240012
PNG
(US9403808, 23)
Show SMILES COC(=O)[C@@H](NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1)C(C)(C)C
Show InChI InChI=1S/C19H27N3O4/c1-19(2,3)15(18(24)25-4)22-16(23)13-9-20-14(12-7-8-12)17(21-13)26-10-11-5-6-11/h9,11-12,15H,5-8,10H2,1-4H3,(H,22,23)/t15-/m1/s1
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n/an/an/an/a 157n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240024
PNG
(US9403808, 35)
Show SMILES COC(=O)[C@H](CC1CC1)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H25N3O4/c1-25-19(24)14(8-11-2-3-11)21-17(23)15-9-20-16(13-6-7-13)18(22-15)26-10-12-4-5-12/h9,11-14H,2-8,10H2,1H3,(H,21,23)/t14-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240042
PNG
(US9403808, 53)
Show SMILES CCC(CC)(NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1)C(=O)NC
Show InChI InChI=1S/C19H28N4O3/c1-4-19(5-2,18(25)20-3)23-16(24)14-10-21-15(13-8-9-13)17(22-14)26-11-12-6-7-12/h10,12-13H,4-9,11H2,1-3H3,(H,20,25)(H,23,24)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240043
PNG
(US9403808, 54 | US9403808, 74)
Show SMILES Cc1csc(n1)C(C)(C)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H24N4O2S/c1-11-10-26-18(21-11)19(2,3)23-16(24)14-8-20-15(13-6-7-13)17(22-14)25-9-12-4-5-12/h8,10,12-13H,4-7,9H2,1-3H3,(H,23,24)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240090
PNG
(US9403808, 101)
Show SMILES NC(=O)C(CC1CCC1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H25F2N5O3/c20-19(21)9-26(10-19)16-18(29-8-12-4-5-12)25-14(7-23-16)17(28)24-13(15(22)27)6-11-2-1-3-11/h7,11-13H,1-6,8-10H2,(H2,22,27)(H,24,28)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240006
PNG
(US9403808, 17)
Show SMILES CC(C)(O)[C@H](CC1CC1)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H29N3O3/c1-20(2,25)16(9-12-3-4-12)23-18(24)15-10-21-17(14-7-8-14)19(22-15)26-11-13-5-6-13/h10,12-14,16,25H,3-9,11H2,1-2H3,(H,23,24)/t16-/m0/s1
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n/an/an/an/a 198n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240011
PNG
(US9403808, 22)
Show SMILES NC(=O)[C@@H](NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)c1ccccc1
Show InChI InChI=1S/C20H21F2N5O3/c21-20(22)10-27(11-20)17-19(30-9-12-6-7-12)25-14(8-24-17)18(29)26-15(16(23)28)13-4-2-1-3-5-13/h1-5,8,12,15H,6-7,9-11H2,(H2,23,28)(H,26,29)/t15-/m0/s1
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n/an/an/an/a 93n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240013
PNG
(US9403808, 24)
Show SMILES CNC(=O)[C@H](CC1CC1)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H26N4O3/c1-20-17(24)14(8-11-2-3-11)22-18(25)15-9-21-16(13-6-7-13)19(23-15)26-10-12-4-5-12/h9,11-14H,2-8,10H2,1H3,(H,20,24)(H,22,25)/t14-/m0/s1
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n/an/an/an/a 199n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240015
PNG
(US9403808, 26)
Show SMILES CNC(=O)[C@H](CC(C)C)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H28N4O3/c1-11(2)8-14(17(24)20-3)22-18(25)15-9-21-16(13-6-7-13)19(23-15)26-10-12-4-5-12/h9,11-14H,4-8,10H2,1-3H3,(H,20,24)(H,22,25)/t14-/m0/s1
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n/an/an/an/a 13.5n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240016
PNG
(US9403808, 27)
Show SMILES CC(C)C[C@H](NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1)C(=O)N(C)C
Show InChI InChI=1S/C20H30N4O3/c1-12(2)9-15(20(26)24(3)4)22-18(25)16-10-21-17(14-7-8-14)19(23-16)27-11-13-5-6-13/h10,12-15H,5-9,11H2,1-4H3,(H,22,25)/t15-/m0/s1
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n/an/an/an/a 2.70n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240030
PNG
(US9403808, 41)
Show SMILES Cc1nc(no1)[C@H](NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1)C1CC1
Show InChI InChI=1S/C19H23N5O3/c1-10-21-17(24-27-10)15(12-4-5-12)23-18(25)14-8-20-16(13-6-7-13)19(22-14)26-9-11-2-3-11/h8,11-13,15H,2-7,9H2,1H3,(H,23,25)/t15-/m1/s1
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n/an/an/an/a 518n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240037
PNG
(US9403808, 48)
Show SMILES FC(F)(F)[C@@H](NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)c1ccccn1
Show InChI InChI=1S/C19H18F5N5O2/c20-18(21)9-29(10-18)15-17(31-8-11-4-5-11)27-13(7-26-15)16(30)28-14(19(22,23)24)12-3-1-2-6-25-12/h1-3,6-7,11,14H,4-5,8-10H2,(H,28,30)/t14-/m0/s1
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n/an/an/an/a 24.4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240044
PNG
(US9403808, 55 | US9403808, 75)
Show SMILES Cc1csc(n1)C(C)(C)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H23F2N5O2S/c1-11-8-29-17(23-11)18(2,3)25-15(27)13-6-22-14(26-9-19(20,21)10-26)16(24-13)28-7-12-4-5-12/h6,8,12H,4-5,7,9-10H2,1-3H3,(H,25,27)
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n/an/an/an/a 5.60n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240065
PNG
(US9403808, 76)
Show SMILES CC(C)[C@H](CC(N)=O)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C18H26N4O3/c1-10(2)13(7-15(19)23)21-17(24)14-8-20-16(12-5-6-12)18(22-14)25-9-11-3-4-11/h8,10-13H,3-7,9H2,1-2H3,(H2,19,23)(H,21,24)/t13-/m0/s1
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n/an/an/an/a 16.3n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240087
PNG
(US9403808, 98)
Show SMILES CNC(=O)C(CC1CCC1)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H28N4O3/c1-21-18(25)15(9-12-3-2-4-12)23-19(26)16-10-22-17(14-7-8-14)20(24-16)27-11-13-5-6-13/h10,12-15H,2-9,11H2,1H3,(H,21,25)(H,23,26)
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n/an/an/an/a 59.3n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240008
PNG
(US9403808, 19)
Show SMILES CC(C)(C)C(CO)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C18H27N3O3/c1-18(2,3)14(9-22)21-16(23)13-8-19-15(12-6-7-12)17(20-13)24-10-11-4-5-11/h8,11-12,14,22H,4-7,9-10H2,1-3H3,(H,21,23)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240016
PNG
(US9403808, 27)
Show SMILES CC(C)C[C@H](NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1)C(=O)N(C)C
Show InChI InChI=1S/C20H30N4O3/c1-12(2)9-15(20(26)24(3)4)22-18(25)16-10-21-17(14-7-8-14)19(23-16)27-11-13-5-6-13/h10,12-15H,5-9,11H2,1-4H3,(H,22,25)/t15-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240023
PNG
(US9403808, 34)
Show SMILES CC(C)C[C@H](NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(=O)N(C)C
Show InChI InChI=1S/C20H29F2N5O3/c1-12(2)7-14(19(29)26(3)4)24-17(28)15-8-23-16(27-10-20(21,22)11-27)18(25-15)30-9-13-5-6-13/h8,12-14H,5-7,9-11H2,1-4H3,(H,24,28)/t14-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240025
PNG
(US9403808, 36)
Show SMILES COC(=O)[C@H](CC1CC1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H24F2N4O4/c1-28-18(27)13(6-11-2-3-11)23-16(26)14-7-22-15(25-9-19(20,21)10-25)17(24-14)29-8-12-4-5-12/h7,11-13H,2-6,8-10H2,1H3,(H,23,26)/t13-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240029
PNG
(US9403808, 40)
Show SMILES Cc1nc(no1)[C@@H](NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1)C1CC1
Show InChI InChI=1S/C19H23N5O3/c1-10-21-17(24-27-10)15(12-4-5-12)23-18(25)14-8-20-16(13-6-7-13)19(22-14)26-9-11-2-3-11/h8,11-13,15H,2-7,9H2,1H3,(H,23,25)/t15-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240031
PNG
(US9403808, 42)
Show SMILES Cc1nc(no1)[C@@H](NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)C1CC1
Show InChI InChI=1S/C19H22F2N6O3/c1-10-23-15(26-30-10)14(12-4-5-12)25-17(28)13-6-22-16(27-8-19(20,21)9-27)18(24-13)29-7-11-2-3-11/h6,11-12,14H,2-5,7-9H2,1H3,(H,25,28)/t14-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240050
PNG
(US9403808, 61)
Show SMILES Cc1nc(no1)C(C)(NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)C1CC1
Show InChI InChI=1S/C20H24F2N6O3/c1-11-24-18(27-31-11)19(2,13-5-6-13)26-16(29)14-7-23-15(28-9-20(21,22)10-28)17(25-14)30-8-12-3-4-12/h7,12-13H,3-6,8-10H2,1-2H3,(H,26,29)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240080
PNG
(US9403808, 91)
Show SMILES CC(C)C(NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(=O)N(C)C
Show InChI InChI=1S/C19H27F2N5O3/c1-11(2)14(18(28)25(3)4)24-16(27)13-7-22-15(26-9-19(20,21)10-26)17(23-13)29-8-12-5-6-12/h7,11-12,14H,5-6,8-10H2,1-4H3,(H,24,27)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240092
PNG
(US9403808, 103)
Show SMILES CN(C)C(=O)C(CC1CCC1)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C21H30N4O3/c1-25(2)21(27)16(10-13-4-3-5-13)23-19(26)17-11-22-18(15-8-9-15)20(24-17)28-12-14-6-7-14/h11,13-16H,3-10,12H2,1-2H3,(H,23,26)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240093
PNG
(US9403808, 104)
Show SMILES NC(=O)C(CC1CCC1)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H26N4O3/c20-17(24)14(8-11-2-1-3-11)22-18(25)15-9-21-16(13-6-7-13)19(23-15)26-10-12-4-5-12/h9,11-14H,1-8,10H2,(H2,20,24)(H,22,25)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM239994
PNG
(US9403808, 5)
Show SMILES Cc1nc(no1)C(C)(C)NC(=O)c1cnc(N2CCC2)c(n1)-c1cccc(Cl)c1
Show InChI InChI=1S/C20H21ClN6O2/c1-12-23-19(26-29-12)20(2,3)25-18(28)15-11-22-17(27-8-5-9-27)16(24-15)13-6-4-7-14(21)10-13/h4,6-7,10-11H,5,8-9H2,1-3H3,(H,25,28)
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n/an/an/an/a 140n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240005
PNG
(US9403808, 16)
Show SMILES CC(C)(O)[C@H](CC1CC1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H28F2N4O3/c1-19(2,28)15(7-12-3-4-12)25-17(27)14-8-23-16(26-10-20(21,22)11-26)18(24-14)29-9-13-5-6-13/h8,12-13,15,28H,3-7,9-11H2,1-2H3,(H,25,27)/t15-/m0/s1
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n/an/an/an/a 36.9n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240010
PNG
(US9403808, 21)
Show SMILES OCC(NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)C1CC1
Show InChI InChI=1S/C17H22F2N4O3/c18-17(19)8-23(9-17)14-16(26-7-10-1-2-10)22-12(5-20-14)15(25)21-13(6-24)11-3-4-11/h5,10-11,13,24H,1-4,6-9H2,(H,21,25)
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n/an/an/an/a 61.3n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240014
PNG
(US9403808, 25)
Show SMILES CN(C)C(=O)[C@H](CC1CC1)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H28N4O3/c1-24(2)20(26)15(9-12-3-4-12)22-18(25)16-10-21-17(14-7-8-14)19(23-16)27-11-13-5-6-13/h10,12-15H,3-9,11H2,1-2H3,(H,22,25)/t15-/m0/s1
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n/an/an/an/a 14.6n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240020
PNG
(US9403808, 31)
Show SMILES CNC(=O)[C@H](CC1CC1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H25F2N5O3/c1-22-16(27)13(6-11-2-3-11)24-17(28)14-7-23-15(26-9-19(20,21)10-26)18(25-14)29-8-12-4-5-12/h7,11-13H,2-6,8-10H2,1H3,(H,22,27)(H,24,28)/t13-/m0/s1
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n/an/an/an/a 124n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240034
PNG
(US9403808, 45)
Show SMILES Cc1nc(no1)C(C)(C)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C18H23N5O3/c1-10-20-17(23-26-10)18(2,3)22-15(24)13-8-19-14(12-6-7-12)16(21-13)25-9-11-4-5-11/h8,11-12H,4-7,9H2,1-3H3,(H,22,24)
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n/an/an/an/a 51.4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240038
PNG
(US9403808, 49)
Show SMILES FC(F)(F)[C@@H](NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1)c1ccccn1
Show InChI InChI=1S/C19H19F3N4O2/c20-19(21,22)16(13-3-1-2-8-23-13)26-17(27)14-9-24-15(12-6-7-12)18(25-14)28-10-11-4-5-11/h1-3,8-9,11-12,16H,4-7,10H2,(H,26,27)/t16-/m0/s1
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n/an/an/an/a 107n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240043
PNG
(US9403808, 54 | US9403808, 74)
Show SMILES Cc1csc(n1)C(C)(C)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H24N4O2S/c1-11-10-26-18(21-11)19(2,3)23-16(24)14-8-20-15(13-6-7-13)17(22-14)25-9-12-4-5-12/h8,10,12-13H,4-7,9H2,1-3H3,(H,23,24)
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n/an/an/an/a 188n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240045
PNG
(US9403808, 56)
Show SMILES C[C@@H](NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)c1noc(C)n1
Show InChI InChI=1S/C17H20F2N6O3/c1-9(13-22-10(2)28-24-13)21-15(26)12-5-20-14(25-7-17(18,19)8-25)16(23-12)27-6-11-3-4-11/h5,9,11H,3-4,6-8H2,1-2H3,(H,21,26)/t9-/m1/s1
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n/an/an/an/a 72.5n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240048
PNG
(US9403808, 59)
Show SMILES C[C@@](NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)(C(N)=O)c1ccccc1
Show InChI InChI=1S/C21H23F2N5O3/c1-20(19(24)30,14-5-3-2-4-6-14)27-17(29)15-9-25-16(28-11-21(22,23)12-28)18(26-15)31-10-13-7-8-13/h2-6,9,13H,7-8,10-12H2,1H3,(H2,24,30)(H,27,29)/t20-/m0/s1
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n/an/an/an/a 49.2n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240057
PNG
(US9403808, 68)
Show SMILES NC(=O)[C@@H](NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H20ClF2N5O3/c21-13-5-3-12(4-6-13)15(16(24)29)27-18(30)14-7-25-17(28-9-20(22,23)10-28)19(26-14)31-8-11-1-2-11/h3-7,11,15H,1-2,8-10H2,(H2,24,29)(H,27,30)/t15-/m0/s1
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n/an/an/an/a 116n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240077
PNG
(US9403808, 88)
Show SMILES CC(C)C(NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(N)=O
Show InChI InChI=1S/C17H23F2N5O3/c1-9(2)12(13(20)25)23-15(26)11-5-21-14(24-7-17(18,19)8-24)16(22-11)27-6-10-3-4-10/h5,9-10,12H,3-4,6-8H2,1-2H3,(H2,20,25)(H,23,26)
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n/an/an/an/a 79.1n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240080
PNG
(US9403808, 91)
Show SMILES CC(C)C(NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(=O)N(C)C
Show InChI InChI=1S/C19H27F2N5O3/c1-11(2)14(18(28)25(3)4)24-16(27)13-7-22-15(26-9-19(20,21)10-26)17(23-13)29-8-12-5-6-12/h7,11-12,14H,5-6,8-10H2,1-4H3,(H,24,27)
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n/an/an/an/a 20.5n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM240095
PNG
(US9403808, 106)
Show SMILES CC(C)(CC(N)=O)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C17H24N4O3/c1-17(2,7-13(18)22)21-15(23)12-8-19-14(11-5-6-11)16(20-12)24-9-10-3-4-10/h8,10-11H,3-7,9H2,1-2H3,(H2,18,22)(H,21,23)
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n/an/an/an/a 43.2n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM239998
PNG
(US9403808, 9)
Show SMILES Cc1nc(no1)C1(CCC1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H22F2N6O3/c1-11-23-17(26-30-11)18(5-2-6-18)25-15(28)13-7-22-14(27-9-19(20,21)10-27)16(24-13)29-8-12-3-4-12/h7,12H,2-6,8-10H2,1H3,(H,25,28)
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n/an/an/an/a 1.29E+3n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240009
PNG
(US9403808, 20)
Show SMILES Cc1nc(no1)[C@H](CC1CC1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H24F2N6O3/c1-11-24-16(27-31-11)14(6-12-2-3-12)25-18(29)15-7-23-17(28-9-20(21,22)10-28)19(26-15)30-8-13-4-5-13/h7,12-14H,2-6,8-10H2,1H3,(H,25,29)/t14-/m0/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240019
PNG
(US9403808, 30)
Show SMILES CCC(CC)(NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1)C(=O)OC
Show InChI InChI=1S/C19H27N3O4/c1-4-19(5-2,18(24)25-3)22-16(23)14-10-20-15(13-8-9-13)17(21-14)26-11-12-6-7-12/h10,12-13H,4-9,11H2,1-3H3,(H,22,23)
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n/an/an/an/a 255n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240045
PNG
(US9403808, 56)
Show SMILES C[C@@H](NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)c1noc(C)n1
Show InChI InChI=1S/C17H20F2N6O3/c1-9(13-22-10(2)28-24-13)21-15(26)12-5-20-14(25-7-17(18,19)8-25)16(23-12)27-6-11-3-4-11/h5,9,11H,3-4,6-8H2,1-2H3,(H,21,26)/t9-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240051
PNG
(US9403808, 62)
Show SMILES Cc1nc(no1)C(C)(NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1)C1CC1
Show InChI InChI=1S/C20H25N5O3/c1-11-22-19(25-28-11)20(2,14-7-8-14)24-17(26)15-9-21-16(13-5-6-13)18(23-15)27-10-12-3-4-12/h9,12-14H,3-8,10H2,1-2H3,(H,24,26)
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n/an/an/an/a 1.65E+3n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240069
PNG
(US9403808, 80)
Show SMILES COC(=O)C(C)(NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1)C1CC1
Show InChI InChI=1S/C19H24F2N4O4/c1-18(12-5-6-12,17(27)28-2)24-15(26)13-7-22-14(25-9-19(20,21)10-25)16(23-13)29-8-11-3-4-11/h7,11-12H,3-6,8-10H2,1-2H3,(H,24,26)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240074
PNG
(US9403808, 85)
Show SMILES NC(=O)CC1(COC1)NC(=O)c1cnc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C17H21F2N5O4/c18-17(19)6-24(7-17)13-15(28-5-10-1-2-10)22-11(4-21-13)14(26)23-16(3-12(20)25)8-27-9-16/h4,10H,1-3,5-9H2,(H2,20,25)(H,23,26)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240083
PNG
(US9403808, 94)
Show SMILES OCC1(CCCCC1)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H27N3O3/c23-12-19(8-2-1-3-9-19)22-17(24)15-10-20-16(14-6-7-14)18(21-15)25-11-13-4-5-13/h10,13-14,23H,1-9,11-12H2,(H,22,24)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM240094
PNG
(US9403808, 105)
Show SMILES OCC(CC1CCC1)NC(=O)c1cnc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H27N3O3/c23-10-15(8-12-2-1-3-12)21-18(24)16-9-20-17(14-6-7-14)19(22-16)25-11-13-4-5-13/h9,12-15,23H,1-8,10-11H2,(H,21,24)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%