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Patent code US9403831

Compile Data Set for Download or QSAR
Found 42 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM238943
PNG
(US9403831, 32)
Show SMILES OCCn1cc(cn1)-c1cnc(nc1)N1CCOC(Cn2nnc3ncc(nc23)-c2ccc(F)c(c2)C#N)C1
Show InChI InChI=1S/C25H22FN11O2/c26-21-2-1-16(7-17(21)8-27)22-12-28-23-24(32-22)37(34-33-23)15-20-14-35(4-6-39-20)25-29-9-18(10-30-25)19-11-31-36(13-19)3-5-38/h1-2,7,9-13,20,38H,3-6,14-15H2
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n/an/a 1n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; HANDOK INC.

US Patent


Assay Description
The c-Met kinase inhibitory activity was analyzed using dissociation enhanced lanthanide fluoro-immunoassay (DELFIA, Perkin Elmer), which is a kind o...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM238946
PNG
(US9403831, 39)
Show SMILES CN1CCN(Cc2ccc(cc2F)-c2cnc(nc2)N2CCOC(Cn3nnc4ncc(nc34)-c3ccc(F)c(c3)C#N)C2)CC1
Show InChI InChI=1S/C32H31F2N11O/c1-42-6-8-43(9-7-42)18-23-3-2-21(13-28(23)34)25-15-37-32(38-16-25)44-10-11-46-26(19-44)20-45-31-30(40-41-45)36-17-29(39-31)22-4-5-27(33)24(12-22)14-35/h2-5,12-13,15-17,26H,6-11,18-20H2,1H3
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KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; HANDOK INC.

US Patent


Assay Description
The c-Met kinase inhibitory activity was analyzed using dissociation enhanced lanthanide fluoro-immunoassay (DELFIA, Perkin Elmer), which is a kind o...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM238935
PNG
(US9403831, 20)
Show SMILES CN1CCC(CC1)c1cnc(nc1)N1CCO[C@H](Cn2nnc3ncc(nc23)-c2cnn(C)c2)C1
Show InChI InChI=1S/C23H29N11O/c1-31-5-3-16(4-6-31)17-9-25-23(26-10-17)33-7-8-35-19(14-33)15-34-22-21(29-30-34)24-12-20(28-22)18-11-27-32(2)13-18/h9-13,16,19H,3-8,14-15H2,1-2H3/t19-/m0/s1
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KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; HANDOK INC.

US Patent


Assay Description
The c-Met kinase inhibitory activity was analyzed using dissociation enhanced lanthanide fluoro-immunoassay (DELFIA, Perkin Elmer), which is a kind o...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM238944
PNG
(US9403831, 30)
Show SMILES Fc1ccc(cc1C#N)-c1cnc2nnn(C[C@@H]3CN(CCO3)c3ncc(cn3)C3=CCNCC3)c2n1
Show InChI InChI=1S/C25H23FN10O/c26-21-2-1-17(9-18(21)10-27)22-13-29-23-24(32-22)36(34-33-23)15-20-14-35(7-8-37-20)25-30-11-19(12-31-25)16-3-5-28-6-4-16/h1-3,9,11-13,20,28H,4-8,14-15H2/t20-/m0/s1
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KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; HANDOK INC.

US Patent


Assay Description
The c-Met kinase inhibitory activity was analyzed using dissociation enhanced lanthanide fluoro-immunoassay (DELFIA, Perkin Elmer), which is a kind o...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM238942
PNG
(US9403831, 31)
Show SMILES OCCn1cc(cn1)-c1cnc(nc1)N1CCO[C@H](Cn2nnc3ncc(nc23)-c2cccc(c2)C#N)C1
Show InChI InChI=1S/C25H23N11O2/c26-9-17-2-1-3-18(8-17)22-13-27-23-24(31-22)36(33-32-23)16-21-15-34(5-7-38-21)25-28-10-19(11-29-25)20-12-30-35(14-20)4-6-37/h1-3,8,10-14,21,37H,4-7,15-16H2/t21-/m0/s1
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KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; HANDOK INC.

US Patent


Assay Description
The c-Met kinase inhibitory activity was analyzed using dissociation enhanced lanthanide fluoro-immunoassay (DELFIA, Perkin Elmer), which is a kind o...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM238964
PNG
(US9403831, 29)
Show SMILES Cn1cc(cn1)-c1cnc(nc1)N1CCO[C@H](Cn2nnc3ncc(nc23)-c2ccc(F)c(c2)C#N)C1
Show InChI InChI=1S/C24H20FN11O/c1-34-12-18(10-30-34)17-8-28-24(29-9-17)35-4-5-37-19(13-35)14-36-23-22(32-33-36)27-11-21(31-23)15-2-3-20(25)16(6-15)7-26/h2-3,6,8-12,19H,4-5,13-14H2,1H3/t19-/m0/s1
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KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; HANDOK INC.

US Patent


Assay Description
The c-Met kinase inhibitory activity was analyzed using dissociation enhanced lanthanide fluoro-immunoassay (DELFIA, Perkin Elmer), which is a kind o...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM238928
PNG
(US9403831, 24)
Show SMILES OCCN1CCC(=CC1)c1cnc(nc1)N1CCO[C@H](Cn2nnc3ncc(nc23)-c2cccc(c2)C#N)C1
Show InChI InChI=1S/C27H28N10O2/c28-13-19-2-1-3-21(12-19)24-16-29-25-26(32-24)37(34-33-25)18-23-17-36(9-11-39-23)27-30-14-22(15-31-27)20-4-6-35(7-5-20)8-10-38/h1-4,12,14-16,23,38H,5-11,17-18H2/t23-/m0/s1
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KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; HANDOK INC.

US Patent


Assay Description
The c-Met kinase inhibitory activity was analyzed using dissociation enhanced lanthanide fluoro-immunoassay (DELFIA, Perkin Elmer), which is a kind o...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM238952
PNG
(US9403831, 37)
Show SMILES Cn1cc(cn1)-c1cnc2nnn(CC3CCCN(C3)c3ncc(cn3)-c3cnn(c3)C3CCNCC3)c2n1
Show InChI InChI=1S/C26H31N13/c1-36-16-21(12-31-36)23-13-28-24-25(33-23)39(35-34-24)15-18-3-2-8-37(14-18)26-29-9-19(10-30-26)20-11-32-38(17-20)22-4-6-27-7-5-22/h9-13,16-18,22,27H,2-8,14-15H2,1H3
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KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; HANDOK INC.

US Patent


Assay Description
The c-Met kinase inhibitory activity was analyzed using dissociation enhanced lanthanide fluoro-immunoassay (DELFIA, Perkin Elmer), which is a kind o...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM238947
PNG
(US9403831, 40)
Show SMILES CN1CCN(Cc2ccc(cc2F)-c2cnc(nc2)N2CCOC(Cn3nnc4ncc(nc34)-c3cnn(C)c3)C2)CC1
Show InChI InChI=1S/C29H33FN12O/c1-38-5-7-40(8-6-38)17-21-4-3-20(11-25(21)30)22-12-32-29(33-13-22)41-9-10-43-24(18-41)19-42-28-27(36-37-42)31-15-26(35-28)23-14-34-39(2)16-23/h3-4,11-16,24H,5-10,17-19H2,1-2H3
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KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; HANDOK INC.

US Patent


Assay Description
The c-Met kinase inhibitory activity was analyzed using dissociation enhanced lanthanide fluoro-immunoassay (DELFIA, Perkin Elmer), which is a kind o...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM238925
PNG
(US9403831, 6)
Show SMILES Cn1cc(cn1)-c1cnc2nnn(C[C@@H]3CN(CCO3)c3ncc(cn3)-c3cnn(c3)C3CCNCC3)c2n1
Show InChI InChI=1S/C25H29N13O/c1-35-13-19(11-30-35)22-12-27-23-24(32-22)38(34-33-23)16-21-15-36(6-7-39-21)25-28-8-17(9-29-25)18-10-31-37(14-18)20-2-4-26-5-3-20/h8-14,20-21,26H,2-7,15-16H2,1H3/t21-/m0/s1
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KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; HANDOK INC.

US Patent


Assay Description
The c-Met kinase inhibitory activity was analyzed using dissociation enhanced lanthanide fluoro-immunoassay (DELFIA, Perkin Elmer), which is a kind o...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM238951
PNG
(US9403831, 36)
Show SMILES Cn1cc(cn1)-c1cnc2nnn(CC3CCCN(C3)c3ncc(cn3)-c3cnn(CCO)c3)c2n1
Show InChI InChI=1S/C23H26N12O/c1-32-14-19(10-27-32)20-11-24-21-22(29-20)35(31-30-21)13-16-3-2-4-33(12-16)23-25-7-17(8-26-23)18-9-28-34(15-18)5-6-36/h7-11,14-16,36H,2-6,12-13H2,1H3
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KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; HANDOK INC.

US Patent


Assay Description
The c-Met kinase inhibitory activity was analyzed using dissociation enhanced lanthanide fluoro-immunoassay (DELFIA, Perkin Elmer), which is a kind o...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM238953
PNG
(US9403831, 17)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2cnc(nc2)N2CCO[C@H](Cn3nnc4ncc(nc34)-c3cnn(C)c3)C2)CC1
Show InChI InChI=1S/C29H34N12O/c1-37-7-9-39(10-8-37)17-21-3-5-22(6-4-21)23-13-31-29(32-14-23)40-11-12-42-25(19-40)20-41-28-27(35-36-41)30-16-26(34-28)24-15-33-38(2)18-24/h3-6,13-16,18,25H,7-12,17,19-20H2,1-2H3/t25-/m0/s1
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KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; HANDOK INC.

US Patent


Assay Description
The c-Met kinase inhibitory activity was analyzed using dissociation enhanced lanthanide fluoro-immunoassay (DELFIA, Perkin Elmer), which is a kind o...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM238965
PNG
(US9403831, 38)
Show SMILES OCCN1CCC(=CC1)c1cnc(nc1)N1CCOC(Cn2nnc3ncc(nc23)-c2ccc(F)c(c2)C#N)C1
Show InChI InChI=1S/C27H27FN10O2/c28-23-2-1-19(11-20(23)12-29)24-15-30-25-26(33-24)38(35-34-25)17-22-16-37(8-10-40-22)27-31-13-21(14-32-27)18-3-5-36(6-4-18)7-9-39/h1-3,11,13-15,22,39H,4-10,16-17H2
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KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; HANDOK INC.

US Patent


Assay Description
The c-Met kinase inhibitory activity was analyzed using dissociation enhanced lanthanide fluoro-immunoassay (DELFIA, Perkin Elmer), which is a kind o...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM238959
PNG
(US9403831, 23 | US9403831, 25)
Show SMILES CN1CCC(=CC1)c1cnc(nc1)N1CCO[C@H](Cn2nnc3ncc(nc23)-c2cccc(c2)C#N)C1
Show InChI InChI=1S/C26H26N10O/c1-34-7-5-19(6-8-34)21-13-29-26(30-14-21)35-9-10-37-22(16-35)17-36-25-24(32-33-36)28-15-23(31-25)20-4-2-3-18(11-20)12-27/h2-5,11,13-15,22H,6-10,16-17H2,1H3/t22-/m0/s1
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KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; HANDOK INC.

US Patent


Assay Description
The c-Met kinase inhibitory activity was analyzed using dissociation enhanced lanthanide fluoro-immunoassay (DELFIA, Perkin Elmer), which is a kind o...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM238939
PNG
(US9403831, 11)
Show SMILES Cn1cc(cn1)-c1cnc2nnn(C[C@@H]3CN(CCO3)c3ncc(cn3)-c3cnn(CCO)c3)c2n1
Show InChI InChI=1S/C22H24N12O2/c1-31-11-17(9-26-31)19-10-23-20-21(28-19)34(30-29-20)14-18-13-32(3-5-36-18)22-24-6-15(7-25-22)16-8-27-33(12-16)2-4-35/h6-12,18,35H,2-5,13-14H2,1H3/t18-/m0/s1
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KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; HANDOK INC.

US Patent


Assay Description
The c-Met kinase inhibitory activity was analyzed using dissociation enhanced lanthanide fluoro-immunoassay (DELFIA, Perkin Elmer), which is a kind o...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM238950
PNG
(US9403831, 35)
Show SMILES Cn1cc(cn1)-c1cnc2nnn(CC3CCCN(C3)c3ncc(cn3)C3=CCN(CCO)CC3)c2n1
Show InChI InChI=1S/C25H31N11O/c1-33-17-21(13-29-33)22-14-26-23-24(30-22)36(32-31-23)16-18-3-2-6-35(15-18)25-27-11-20(12-28-25)19-4-7-34(8-5-19)9-10-37/h4,11-14,17-18,37H,2-3,5-10,15-16H2,1H3
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KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; HANDOK INC.

US Patent


Assay Description
The c-Met kinase inhibitory activity was analyzed using dissociation enhanced lanthanide fluoro-immunoassay (DELFIA, Perkin Elmer), which is a kind o...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM238948
PNG
(US9403831, 34)
Show SMILES CN1CCC(=CC1)c1cnc(nc1)N1CCCC(Cn2nnc3ncc(nc23)-c2cnn(C)c2)C1
Show InChI InChI=1S/C24H29N11/c1-32-8-5-18(6-9-32)19-10-26-24(27-11-19)34-7-3-4-17(14-34)15-35-23-22(30-31-35)25-13-21(29-23)20-12-28-33(2)16-20/h5,10-13,16-17H,3-4,6-9,14-15H2,1-2H3
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KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; HANDOK INC.

US Patent


Assay Description
The c-Met kinase inhibitory activity was analyzed using dissociation enhanced lanthanide fluoro-immunoassay (DELFIA, Perkin Elmer), which is a kind o...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM238949
PNG
(US9403831, 33)
Show SMILES Cn1cc(cn1)-c1cnc2nnn(CC3CCCN(C3)c3ncc(cn3)C3=CCNCC3)c2n1
Show InChI InChI=1S/C23H27N11/c1-32-15-19(11-28-32)20-12-25-21-22(29-20)34(31-30-21)14-16-3-2-8-33(13-16)23-26-9-18(10-27-23)17-4-6-24-7-5-17/h4,9-12,15-16,24H,2-3,5-8,13-14H2,1H3
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KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; HANDOK INC.

US Patent


Assay Description
The c-Met kinase inhibitory activity was analyzed using dissociation enhanced lanthanide fluoro-immunoassay (DELFIA, Perkin Elmer), which is a kind o...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM238937
PNG
(US9403831, 9)
Show SMILES Cn1cc(cn1)-c1cnc2nnn(C[C@@H]3CN(CCO3)c3ncc(cn3)C3=CCOCC3)c2n1
Show InChI InChI=1S/C22H24N10O2/c1-30-12-17(10-26-30)19-11-23-20-21(27-19)32(29-28-20)14-18-13-31(4-7-34-18)22-24-8-16(9-25-22)15-2-5-33-6-3-15/h2,8-12,18H,3-7,13-14H2,1H3/t18-/m0/s1
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KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; HANDOK INC.

US Patent


Assay Description
The c-Met kinase inhibitory activity was analyzed using dissociation enhanced lanthanide fluoro-immunoassay (DELFIA, Perkin Elmer), which is a kind o...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM238963
PNG
(US9403831, 28)
Show SMILES Cn1cc(cn1)-c1cnc(nc1)N1CCO[C@H](Cn2nnc3ncc(nc23)-c2cccc(c2)C#N)C1
Show InChI InChI=1S/C24H21N11O/c1-33-13-19(11-29-33)18-9-27-24(28-10-18)34-5-6-36-20(14-34)15-35-23-22(31-32-35)26-12-21(30-23)17-4-2-3-16(7-17)8-25/h2-4,7,9-13,20H,5-6,14-15H2,1H3/t20-/m0/s1
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n/an/a 4n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; HANDOK INC.

US Patent


Assay Description
The c-Met kinase inhibitory activity was analyzed using dissociation enhanced lanthanide fluoro-immunoassay (DELFIA, Perkin Elmer), which is a kind o...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM238945
PNG
(US9403831, 42)
Show SMILES Cn1cc(cn1)-c1cnc2nnn(C[C@@H]3CN(CCO3)c3ncc(cn3)-c3ccc(CN4CCOCC4)c(F)c3)c2n1
Show InChI InChI=1S/C28H30FN11O2/c1-37-15-22(13-33-37)25-14-30-26-27(34-25)40(36-35-26)18-23-17-39(6-9-42-23)28-31-11-21(12-32-28)19-2-3-20(24(29)10-19)16-38-4-7-41-8-5-38/h2-3,10-15,23H,4-9,16-18H2,1H3/t23-/m0/s1
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KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; HANDOK INC.

US Patent


Assay Description
The c-Met kinase inhibitory activity was analyzed using dissociation enhanced lanthanide fluoro-immunoassay (DELFIA, Perkin Elmer), which is a kind o...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM238940
PNG
(US9403831, 12)
Show SMILES Cn1cc(cn1)-c1cnc2nnn(C[C@@H]3CN(CCO3)c3ncc(cn3)C3=CCN(CCO)CC3)c2n1
Show InChI InChI=1S/C24H29N11O2/c1-32-14-19(12-28-32)21-13-25-22-23(29-21)35(31-30-22)16-20-15-34(7-9-37-20)24-26-10-18(11-27-24)17-2-4-33(5-3-17)6-8-36/h2,10-14,20,36H,3-9,15-16H2,1H3/t20-/m0/s1
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KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; HANDOK INC.

US Patent


Assay Description
The c-Met kinase inhibitory activity was analyzed using dissociation enhanced lanthanide fluoro-immunoassay (DELFIA, Perkin Elmer), which is a kind o...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM238931
PNG
(US9403831, 8)
Show SMILES Cn1cc(cn1)-c1cnc2nnn(C[C@@H]3CN(CCO3)c3ncc(cn3)-c3cnn(c3)C3CCN(CCO)CC3)c2n1
Show InChI InChI=1S/C27H33N13O2/c1-36-15-21(13-31-36)24-14-28-25-26(33-24)40(35-34-25)18-23-17-38(7-9-42-23)27-29-10-19(11-30-27)20-12-32-39(16-20)22-2-4-37(5-3-22)6-8-41/h10-16,22-23,41H,2-9,17-18H2,1H3/t23-/m0/s1
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KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; HANDOK INC.

US Patent


Assay Description
The c-Met kinase inhibitory activity was analyzed using dissociation enhanced lanthanide fluoro-immunoassay (DELFIA, Perkin Elmer), which is a kind o...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM238927
PNG
(US9403831, 22)
Show SMILES N#Cc1cccc(c1)-c1cnc2nnn(C[C@@H]3CN(CCO3)c3ncc(cn3)C3=CCNCC3)c2n1
Show InChI InChI=1S/C25H24N10O/c26-11-17-2-1-3-19(10-17)22-14-28-23-24(31-22)35(33-32-23)16-21-15-34(8-9-36-21)25-29-12-20(13-30-25)18-4-6-27-7-5-18/h1-4,10,12-14,21,27H,5-9,15-16H2/t21-/m0/s1
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KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; HANDOK INC.

US Patent


Assay Description
The c-Met kinase inhibitory activity was analyzed using dissociation enhanced lanthanide fluoro-immunoassay (DELFIA, Perkin Elmer), which is a kind o...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM238938
PNG
(US9403831, 10)
Show SMILES CN1CCC(=CC1)c1cnc(nc1)N1CCO[C@H](Cn2nnc3ncc(nc23)-c2cnn(C)c2)C1
Show InChI InChI=1S/C23H27N11O/c1-31-5-3-16(4-6-31)17-9-25-23(26-10-17)33-7-8-35-19(14-33)15-34-22-21(29-30-34)24-12-20(28-22)18-11-27-32(2)13-18/h3,9-13,19H,4-8,14-15H2,1-2H3/t19-/m0/s1
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KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; HANDOK INC.

US Patent


Assay Description
The c-Met kinase inhibitory activity was analyzed using dissociation enhanced lanthanide fluoro-immunoassay (DELFIA, Perkin Elmer), which is a kind o...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM238961
PNG
(US9403831, 26)
Show SMILES OCCN1CCC(CC1)c1cnc(nc1)N1CCO[C@H](Cn2nnc3ncc(nc23)-c2cccc(c2)C#N)C1
Show InChI InChI=1S/C27H30N10O2/c28-13-19-2-1-3-21(12-19)24-16-29-25-26(32-24)37(34-33-25)18-23-17-36(9-11-39-23)27-30-14-22(15-31-27)20-4-6-35(7-5-20)8-10-38/h1-3,12,14-16,20,23,38H,4-11,17-18H2/t23-/m0/s1
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KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; HANDOK INC.

US Patent


Assay Description
The c-Met kinase inhibitory activity was analyzed using dissociation enhanced lanthanide fluoro-immunoassay (DELFIA, Perkin Elmer), which is a kind o...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM238936
PNG
(US9403831, 21)
Show SMILES Cn1cc(cn1)-c1cnc2nnn(C[C@@H]3CN(CCO3)c3ncc(cn3)C3CCN(CCO)CC3)c2n1
Show InChI InChI=1S/C24H31N11O2/c1-32-14-19(12-28-32)21-13-25-22-23(29-21)35(31-30-22)16-20-15-34(7-9-37-20)24-26-10-18(11-27-24)17-2-4-33(5-3-17)6-8-36/h10-14,17,20,36H,2-9,15-16H2,1H3/t20-/m0/s1
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KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; HANDOK INC.

US Patent


Assay Description
The c-Met kinase inhibitory activity was analyzed using dissociation enhanced lanthanide fluoro-immunoassay (DELFIA, Perkin Elmer), which is a kind o...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM238959
PNG
(US9403831, 23 | US9403831, 25)
Show SMILES CN1CCC(=CC1)c1cnc(nc1)N1CCO[C@H](Cn2nnc3ncc(nc23)-c2cccc(c2)C#N)C1
Show InChI InChI=1S/C26H26N10O/c1-34-7-5-19(6-8-34)21-13-29-26(30-14-21)35-9-10-37-22(16-35)17-36-25-24(32-33-36)28-15-23(31-25)20-4-2-3-18(11-20)12-27/h2-5,11,13-15,22H,6-10,16-17H2,1H3/t22-/m0/s1
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KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; HANDOK INC.

US Patent


Assay Description
The c-Met kinase inhibitory activity was analyzed using dissociation enhanced lanthanide fluoro-immunoassay (DELFIA, Perkin Elmer), which is a kind o...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM238962
PNG
(US9403831, 27)
Show SMILES N#Cc1cccc(c1)-c1cnc2nnn(C[C@@H]3CN(CCO3)c3ncc(cn3)-c3cnn(c3)C3CCNCC3)c2n1
Show InChI InChI=1S/C28H28N12O/c29-11-19-2-1-3-20(10-19)25-15-31-26-27(35-25)40(37-36-26)18-24-17-38(8-9-41-24)28-32-12-21(13-33-28)22-14-34-39(16-22)23-4-6-30-7-5-23/h1-3,10,12-16,23-24,30H,4-9,17-18H2/t24-/m0/s1
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KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; HANDOK INC.

US Patent


Assay Description
The c-Met kinase inhibitory activity was analyzed using dissociation enhanced lanthanide fluoro-immunoassay (DELFIA, Perkin Elmer), which is a kind o...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM238934
PNG
(US9403831, 18)
Show SMILES Cn1cc(cn1)-c1cnc2nnn(C[C@@H]3CN(CCO3)c3ncc(cn3)-c3ccc(CN4CCOCC4)cc3)c2n1
Show InChI InChI=1S/C28H31N11O2/c1-36-17-23(14-32-36)25-15-29-26-27(33-25)39(35-34-26)19-24-18-38(8-11-41-24)28-30-12-22(13-31-28)21-4-2-20(3-5-21)16-37-6-9-40-10-7-37/h2-5,12-15,17,24H,6-11,16,18-19H2,1H3/t24-/m0/s1
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KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; HANDOK INC.

US Patent


Assay Description
The c-Met kinase inhibitory activity was analyzed using dissociation enhanced lanthanide fluoro-immunoassay (DELFIA, Perkin Elmer), which is a kind o...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM238957
PNG
(US9403831, 48)
Show SMILES CN1CCN(CC1)C(=O)c1ccc(cc1)-c1cnc(nc1)N1CCCC(Cn2nnc3ncc(nc23)-c2cnn(C)c2)C1
Show InChI InChI=1S/C30H34N12O/c1-38-10-12-40(13-11-38)29(43)23-7-5-22(6-8-23)24-14-32-30(33-15-24)41-9-3-4-21(18-41)19-42-28-27(36-37-42)31-17-26(35-28)25-16-34-39(2)20-25/h5-8,14-17,20-21H,3-4,9-13,18-19H2,1-2H3
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KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; HANDOK INC.

US Patent


Assay Description
The c-Met kinase inhibitory activity was analyzed using dissociation enhanced lanthanide fluoro-immunoassay (DELFIA, Perkin Elmer), which is a kind o...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM238933
PNG
(US9403831, 15)
Show SMILES CN1CCN(CCOc2ccc(cc2)-c2cnc(nc2)N2CCO[C@H](Cn3nnc4ncc(nc34)-c3cnn(C)c3)C2)CC1
Show InChI InChI=1S/C30H36N12O2/c1-38-7-9-40(10-8-38)11-13-43-25-5-3-22(4-6-25)23-15-32-30(33-16-23)41-12-14-44-26(20-41)21-42-29-28(36-37-42)31-18-27(35-29)24-17-34-39(2)19-24/h3-6,15-19,26H,7-14,20-21H2,1-2H3/t26-/m0/s1
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KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; HANDOK INC.

US Patent


Assay Description
The c-Met kinase inhibitory activity was analyzed using dissociation enhanced lanthanide fluoro-immunoassay (DELFIA, Perkin Elmer), which is a kind o...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM238929
PNG
(US9403831, 7)
Show SMILES CN1CCC(CC1)n1cc(cn1)-c1cnc(nc1)N1CCO[C@H](Cn2nnc3ncc(nc23)-c2cnn(C)c2)C1
Show InChI InChI=1S/C26H31N13O/c1-35-5-3-21(4-6-35)38-15-19(11-31-38)18-9-28-26(29-10-18)37-7-8-40-22(16-37)17-39-25-24(33-34-39)27-13-23(32-25)20-12-30-36(2)14-20/h9-15,21-22H,3-8,16-17H2,1-2H3/t22-/m0/s1
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KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; HANDOK INC.

US Patent


Assay Description
The c-Met kinase inhibitory activity was analyzed using dissociation enhanced lanthanide fluoro-immunoassay (DELFIA, Perkin Elmer), which is a kind o...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM238926
PNG
(US9403831, 19)
Show SMILES CN1CCN(CCOc2cnc(nc2)N2CCO[C@H](Cn3nnc4ncc(nc34)-c3cnn(C)c3)C2)CC1
Show InChI InChI=1S/C24H32N12O2/c1-32-3-5-34(6-4-32)7-9-37-19-12-26-24(27-13-19)35-8-10-38-20(16-35)17-36-23-22(30-31-36)25-14-21(29-23)18-11-28-33(2)15-18/h11-15,20H,3-10,16-17H2,1-2H3/t20-/m0/s1
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KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; HANDOK INC.

US Patent


Assay Description
The c-Met kinase inhibitory activity was analyzed using dissociation enhanced lanthanide fluoro-immunoassay (DELFIA, Perkin Elmer), which is a kind o...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM238955
PNG
(US9403831, 46)
Show SMILES CC(=O)N1CCN(Cc2ccc(cc2)-c2cnc(nc2)N2CCCC(Cn3nnc4ncc(nc34)-c3cnn(C)c3)C2)CC1
Show InChI InChI=1S/C31H36N12O/c1-22(44)41-12-10-40(11-13-41)18-23-5-7-25(8-6-23)26-14-33-31(34-15-26)42-9-3-4-24(19-42)20-43-30-29(37-38-43)32-17-28(36-30)27-16-35-39(2)21-27/h5-8,14-17,21,24H,3-4,9-13,18-20H2,1-2H3
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KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; HANDOK INC.

US Patent


Assay Description
The c-Met kinase inhibitory activity was analyzed using dissociation enhanced lanthanide fluoro-immunoassay (DELFIA, Perkin Elmer), which is a kind o...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM238958
PNG
(US9403831, 49)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2cnc(nc2)N2CCOC(Cn3nnc4ncc(nc34)-c3cccc(c3)C#N)C2)CC1
Show InChI InChI=1S/C32H33N11O/c1-40-9-11-41(12-10-40)20-23-5-7-25(8-6-23)27-17-35-32(36-18-27)42-13-14-44-28(21-42)22-43-31-30(38-39-43)34-19-29(37-31)26-4-2-3-24(15-26)16-33/h2-8,15,17-19,28H,9-14,20-22H2,1H3
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KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; HANDOK INC.

US Patent


Assay Description
The c-Met kinase inhibitory activity was analyzed using dissociation enhanced lanthanide fluoro-immunoassay (DELFIA, Perkin Elmer), which is a kind o...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM238954
PNG
(US9403831, 45)
Show SMILES CC(=O)N1CCN(Cc2ccc(cc2)-c2cnc(nc2)N2CCOC(Cn3nnc4ncc(nc34)-c3cnn(C)c3)C2)CC1
Show InChI InChI=1S/C30H34N12O2/c1-21(43)40-9-7-39(8-10-40)17-22-3-5-23(6-4-22)24-13-32-30(33-14-24)41-11-12-44-26(19-41)20-42-29-28(36-37-42)31-16-27(35-29)25-15-34-38(2)18-25/h3-6,13-16,18,26H,7-12,17,19-20H2,1-2H3
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KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; HANDOK INC.

US Patent


Assay Description
The c-Met kinase inhibitory activity was analyzed using dissociation enhanced lanthanide fluoro-immunoassay (DELFIA, Perkin Elmer), which is a kind o...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM238930
PNG
(US9403831, 4)
Show SMILES Cn1cc(cn1)-c1cnc2nnn(CC3CN(CCO3)c3ncc(cn3)-c3cnn(c3)C3CCNCC3)c2n1
Show InChI InChI=1S/C25H29N13O/c1-35-13-19(11-30-35)22-12-27-23-24(32-22)38(34-33-23)16-21-15-36(6-7-39-21)25-28-8-17(9-29-25)18-10-31-37(14-18)20-2-4-26-5-3-20/h8-14,20-21,26H,2-7,15-16H2,1H3
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KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; HANDOK INC.

US Patent


Assay Description
The c-Met kinase inhibitory activity was analyzed using dissociation enhanced lanthanide fluoro-immunoassay (DELFIA, Perkin Elmer), which is a kind o...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM238956
PNG
(US9403831, 47)
Show SMILES CN1CCN(CC1)C(=O)c1ccc(cc1)-c1cnc(nc1)N1CCOC(Cn2nnc3ncc(nc23)-c2cnn(C)c2)C1
Show InChI InChI=1S/C29H32N12O2/c1-37-7-9-39(10-8-37)28(42)21-5-3-20(4-6-21)22-13-31-29(32-14-22)40-11-12-43-24(18-40)19-41-27-26(35-36-41)30-16-25(34-27)23-15-33-38(2)17-23/h3-6,13-17,24H,7-12,18-19H2,1-2H3
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n/an/a 13n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; HANDOK INC.

US Patent


Assay Description
The c-Met kinase inhibitory activity was analyzed using dissociation enhanced lanthanide fluoro-immunoassay (DELFIA, Perkin Elmer), which is a kind o...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM238932
PNG
(US9403831, 14)
Show SMILES Cn1cc(cn1)-c1cnc2nnn(C[C@@H]3CN(CCO3)c3ncc(cn3)-c3ccc(OCCN4CCOCC4)cc3)c2n1
Show InChI InChI=1S/C29H33N11O3/c1-37-18-23(16-33-37)26-17-30-27-28(34-26)40(36-35-27)20-25-19-39(9-13-43-25)29-31-14-22(15-32-29)21-2-4-24(5-3-21)42-12-8-38-6-10-41-11-7-38/h2-5,14-18,25H,6-13,19-20H2,1H3/t25-/m0/s1
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n/an/a 14n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; HANDOK INC.

US Patent


Assay Description
The c-Met kinase inhibitory activity was analyzed using dissociation enhanced lanthanide fluoro-immunoassay (DELFIA, Perkin Elmer), which is a kind o...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM238941
PNG
(US9403831, 13)
Show SMILES Cn1cc(cn1)-c1cnc2nnn(C[C@@H]3CN(CCO3)c3ncc(cn3)-c3ccc(OCCN4CCOCC4)c(F)c3)c2n1
Show InChI InChI=1S/C29H32FN11O3/c1-38-17-22(15-34-38)25-16-31-27-28(35-25)41(37-36-27)19-23-18-40(7-11-43-23)29-32-13-21(14-33-29)20-2-3-26(24(30)12-20)44-10-6-39-4-8-42-9-5-39/h2-3,12-17,23H,4-11,18-19H2,1H3/t23-/m0/s1
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n/an/a 15n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; HANDOK INC.

US Patent


Assay Description
The c-Met kinase inhibitory activity was analyzed using dissociation enhanced lanthanide fluoro-immunoassay (DELFIA, Perkin Elmer), which is a kind o...


Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM238924
PNG
(US9403831, 5)
Show SMILES CN1CCC(CC1)n1cc(cn1)-c1cnc(nc1)N1CCOC(Cn2nnc3ncc(nc23)-c2cnn(C)c2)C1
Show InChI InChI=1S/C26H31N13O/c1-35-5-3-21(4-6-35)38-15-19(11-31-38)18-9-28-26(29-10-18)37-7-8-40-22(16-37)17-39-25-24(33-34-39)27-13-23(32-25)20-12-30-36(2)14-20/h9-15,21-22H,3-8,16-17H2,1-2H3
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PC cid
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US Patent
n/an/a 29n/an/an/an/an/an/a



KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; HANDOK INC.

US Patent


Assay Description
The c-Met kinase inhibitory activity was analyzed using dissociation enhanced lanthanide fluoro-immunoassay (DELFIA, Perkin Elmer), which is a kind o...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%