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Patent code US9403843

Compile Data Set for Download or QSAR
Found 72 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Calpain-1


(Sus scrofa (pig))
BDBM240262
PNG
(US9403843, 33)
Show SMILES OC(=O)[C@@H]1O[C@H]1C(=O)N[C@@H](Cc1cscn1)C(=O)Nc1nc(cs1)-c1ccc(F)cc1
Show InChI InChI=1S/C19H15FN4O5S2/c20-10-3-1-9(2-4-10)13-7-31-19(23-13)24-16(25)12(5-11-6-30-8-21-11)22-17(26)14-15(29-14)18(27)28/h1-4,6-8,12,14-15H,5H2,(H,22,26)(H,27,28)(H,23,24,25)/t12-,14+,15+/m0/s1
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2.60E+3n/an/an/an/an/an/an/an/a



THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
Full length porcine calpain (156 nM), or papain (236 pM) was added to a solution of 100 mM NaCl, 50 mM HEPES, pH 7.6, 1 mM TCEP, 30 μM Suc-LLVY-AM...


Citation and Details
More data for this
Ligand-Target Pair
Calpain-1


(Sus scrofa (pig))
BDBM50437948
PNG
(CHEMBL2408899 | US9403843, 50)
Show SMILES OC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](Cc1cscn1)C(=O)NCc1cn(nn1)-c1ccc(F)cc1
Show InChI InChI=1S/C19H17FN6O5S/c20-10-1-3-13(4-2-10)26-7-12(24-25-26)6-21-17(27)14(5-11-8-32-9-22-11)23-18(28)15-16(31-15)19(29)30/h1-4,7-9,14-16H,5-6H2,(H,21,27)(H,23,28)(H,29,30)/t14-,15-,16-/m0/s1
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2.90E+3n/an/an/an/an/an/an/an/a



THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
Full length porcine calpain (156 nM), or papain (236 pM) was added to a solution of 100 mM NaCl, 50 mM HEPES, pH 7.6, 1 mM TCEP, 30 μM Suc-LLVY-AM...


Citation and Details
More data for this
Ligand-Target Pair
Calpain-1


(Sus scrofa (pig))
BDBM50437949
PNG
(CHEMBL2408918 | US9403843, 34)
Show SMILES OC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](Cc1cscn1)C(=O)Nc1nc(cs1)-c1ccc(cc1)C#C
Show InChI InChI=1S/C21H16N4O5S2/c1-2-11-3-5-12(6-4-11)15-9-32-21(24-15)25-18(26)14(7-13-8-31-10-22-13)23-19(27)16-17(30-16)20(28)29/h1,3-6,8-10,14,16-17H,7H2,(H,23,27)(H,28,29)(H,24,25,26)/t14-,16-,17-/m0/s1
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3.50E+3n/an/an/an/an/an/an/an/a



THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
Full length porcine calpain (156 nM), or papain (236 pM) was added to a solution of 100 mM NaCl, 50 mM HEPES, pH 7.6, 1 mM TCEP, 30 μM Suc-LLVY-AM...


Citation and Details
More data for this
Ligand-Target Pair
Calpain-1


(Sus scrofa (pig))
BDBM240232
PNG
(US9403843, E64)
Show SMILES CC(C)C[C@H](NC(=O)C1O[C@@H]1C(O)=O)C(=O)NCCCCNC(N)=N
Show InChI InChI=1S/C15H27N5O5/c1-8(2)7-9(20-13(22)10-11(25-10)14(23)24)12(21)18-5-3-4-6-19-15(16)17/h8-11H,3-7H2,1-2H3,(H,18,21)(H,20,22)(H,23,24)(H4,16,17,19)/t9-,10?,11-/m0/s1
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4.00E+3n/an/an/an/an/an/an/an/a



THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
Full length porcine calpain (156 nM), or papain (236 pM) was added to a solution of 100 mM NaCl, 50 mM HEPES, pH 7.6, 1 mM TCEP, 30 μM Suc-LLVY-AM...


Citation and Details
More data for this
Ligand-Target Pair
Calpain-1


(Sus scrofa (pig))
BDBM50437951
PNG
(CHEMBL2408922 | US9403843, 24a)
Show SMILES CC(C)C[C@H](NC(=O)[C@H]1O[C@@H]1C(O)=O)C(=O)Nc1nc(cs1)-c1ccc(F)cc1
Show InChI InChI=1S/C19H20FN3O5S/c1-9(2)7-12(21-17(25)14-15(28-14)18(26)27)16(24)23-19-22-13(8-29-19)10-3-5-11(20)6-4-10/h3-6,8-9,12,14-15H,7H2,1-2H3,(H,21,25)(H,26,27)(H,22,23,24)/t12-,14-,15-/m0/s1
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6.00E+3n/an/an/an/an/an/an/an/a



THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
Full length porcine calpain (156 nM), or papain (236 pM) was added to a solution of 100 mM NaCl, 50 mM HEPES, pH 7.6, 1 mM TCEP, 30 μM Suc-LLVY-AM...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240264
PNG
(US9403843, 86)
Show SMILES CC(C)C[C@H](NC(=O)[C@H]1O[C@@H]1C(O)=O)C(=O)NCc1cn(nn1)-c1ccc(F)cc1
Show InChI InChI=1S/C19H22FN5O5/c1-10(2)7-14(22-18(27)15-16(30-15)19(28)29)17(26)21-8-12-9-25(24-23-12)13-5-3-11(20)4-6-13/h3-6,9-10,14-16H,7-8H2,1-2H3,(H,21,26)(H,22,27)(H,28,29)/t14-,15-,16-/m0/s1
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n/an/a 30n/an/an/an/an/an/a



THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM50437951
PNG
(CHEMBL2408922 | US9403843, 24a)
Show SMILES CC(C)C[C@H](NC(=O)[C@H]1O[C@@H]1C(O)=O)C(=O)Nc1nc(cs1)-c1ccc(F)cc1
Show InChI InChI=1S/C19H20FN3O5S/c1-9(2)7-12(21-17(25)14-15(28-14)18(26)27)16(24)23-19-22-13(8-29-19)10-3-5-11(20)6-4-10/h3-6,8-9,12,14-15H,7H2,1-2H3,(H,21,25)(H,26,27)(H,22,23,24)/t12-,14-,15-/m0/s1
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n/an/a 30n/an/an/an/an/an/a



THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240272
PNG
(US9403843, 55)
Show SMILES OC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](Cc1cscn1)C(=O)NCc1cn(nn1)-c1ccc(Br)cc1
Show InChI InChI=1S/C19H17BrN6O5S/c20-10-1-3-13(4-2-10)26-7-12(24-25-26)6-21-17(27)14(5-11-8-32-9-22-11)23-18(28)15-16(31-15)19(29)30/h1-4,7-9,14-16H,5-6H2,(H,21,27)(H,23,28)(H,29,30)/t14-,15-,16-/m0/s1
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n/an/a 40n/an/an/an/an/an/a



THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240251
PNG
(US9403843, 23a | US9403843, 23b)
Show SMILES CC(C)C[C@H](NC(=O)[C@H]1O[C@@H]1C(O)=O)C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C16H18F2N2O5/c1-7(2)6-10(19-15(22)12-13(25-12)16(23)24)14(21)20-11-8(17)4-3-5-9(11)18/h3-5,7,10,12-13H,6H2,1-2H3,(H,19,22)(H,20,21)(H,23,24)/t10-,12-,13-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM50437951
PNG
(CHEMBL2408922 | US9403843, 24a)
Show SMILES CC(C)C[C@H](NC(=O)[C@H]1O[C@@H]1C(O)=O)C(=O)Nc1nc(cs1)-c1ccc(F)cc1
Show InChI InChI=1S/C19H20FN3O5S/c1-9(2)7-12(21-17(25)14-15(28-14)18(26)27)16(24)23-19-22-13(8-29-19)10-3-5-11(20)6-4-10/h3-6,8-9,12,14-15H,7H2,1-2H3,(H,21,25)(H,26,27)(H,22,23,24)/t12-,14-,15-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240265
PNG
(US9403843, 87)
Show SMILES CC(C)C[C@H](NC(=O)[C@H]1O[C@@H]1C(O)=O)C(=O)NCc1cn(nn1)-c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C19H24N6O7S/c1-10(2)7-14(22-18(27)15-16(32-15)19(28)29)17(26)21-8-11-9-25(24-23-11)12-3-5-13(6-4-12)33(20,30)31/h3-6,9-10,14-16H,7-8H2,1-2H3,(H,21,26)(H,22,27)(H,28,29)(H2,20,30,31)/t14-,15-,16-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240238
PNG
(US9403843, 25)
Show SMILES CC(C)C[C@H](NC(=O)C1O[C@@H]1C(O)=O)C(=O)NCCCCNS(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C20H28FN3O7S/c1-12(2)11-15(24-19(26)16-17(31-16)20(27)28)18(25)22-9-3-4-10-23-32(29,30)14-7-5-13(21)6-8-14/h5-8,12,15-17,23H,3-4,9-11H2,1-2H3,(H,22,25)(H,24,26)(H,27,28)/t15-,16?,17-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240233
PNG
(US9403843, 27)
Show SMILES CC(C)C[C@H](NC(=O)C1O[C@@H]1C(O)=O)C(=O)NCCCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12
Show InChI InChI=1S/C24H39N5O7S/c1-13(2)11-14(27-22(32)19-20(36-19)23(33)34)21(31)26-10-6-5-9-25-17(30)8-4-3-7-16-18-15(12-37-16)28-24(35)29-18/h13-16,18-20H,3-12H2,1-2H3,(H,25,30)(H,26,31)(H,27,32)(H,33,34)(H2,28,29,35)/t14-,15-,16-,18-,19?,20-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240243
PNG
(US9403843, 68)
Show SMILES CC(C)C[C@H](NC(=O)[C@H]1O[C@@H]1C(O)=O)C(=O)NCCCCNS(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C20H28FN3O7S/c1-12(2)11-15(24-19(26)16-17(31-16)20(27)28)18(25)22-9-3-4-10-23-32(29,30)14-7-5-13(21)6-8-14/h5-8,12,15-17,23H,3-4,9-11H2,1-2H3,(H,22,25)(H,24,26)(H,27,28)/t15-,16-,17-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240262
PNG
(US9403843, 33)
Show SMILES OC(=O)[C@@H]1O[C@H]1C(=O)N[C@@H](Cc1cscn1)C(=O)Nc1nc(cs1)-c1ccc(F)cc1
Show InChI InChI=1S/C19H15FN4O5S2/c20-10-3-1-9(2-4-10)13-7-31-19(23-13)24-16(25)12(5-11-6-30-8-21-11)22-17(26)14-15(29-14)18(27)28/h1-4,6-8,12,14-15H,5H2,(H,22,26)(H,27,28)(H,23,24,25)/t12-,14+,15+/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM50437949
PNG
(CHEMBL2408918 | US9403843, 34)
Show SMILES OC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](Cc1cscn1)C(=O)Nc1nc(cs1)-c1ccc(cc1)C#C
Show InChI InChI=1S/C21H16N4O5S2/c1-2-11-3-5-12(6-4-11)15-9-32-21(24-15)25-18(26)14(7-13-8-31-10-22-13)23-19(27)16-17(30-16)20(28)29/h1,3-6,8-10,14,16-17H,7H2,(H,23,27)(H,28,29)(H,24,25,26)/t14-,16-,17-/m0/s1
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n/an/a 100n/an/an/an/an/an/a



THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240249
PNG
(US9403843, 30a)
Show SMILES OC(=O)[C@H]1O[C@@H]1C(=O)NC(Cc1cnc[nH]1)C(=O)Nc1nc(cs1)-c1ccc(F)cc1
Show InChI InChI=1S/C19H16FN5O5S/c20-10-3-1-9(2-4-10)13-7-31-19(24-13)25-16(26)12(5-11-6-21-8-22-11)23-17(27)14-15(30-14)18(28)29/h1-4,6-8,12,14-15H,5H2,(H,21,22)(H,23,27)(H,28,29)(H,24,25,26)/t12?,14-,15-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240232
PNG
(US9403843, E64)
Show SMILES CC(C)C[C@H](NC(=O)C1O[C@@H]1C(O)=O)C(=O)NCCCCNC(N)=N
Show InChI InChI=1S/C15H27N5O5/c1-8(2)7-9(20-13(22)10-11(25-10)14(23)24)12(21)18-5-3-4-6-19-15(16)17/h8-11H,3-7H2,1-2H3,(H,18,21)(H,20,22)(H,23,24)(H4,16,17,19)/t9-,10?,11-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240255
PNG
(US9403843, 22)
Show SMILES CC(C)C[C@H](NC(=O)[C@H]1O[C@@H]1C(O)=O)C(=O)Nc1ccccc1
Show InChI InChI=1S/C16H20N2O5/c1-9(2)8-11(14(19)17-10-6-4-3-5-7-10)18-15(20)12-13(23-12)16(21)22/h3-7,9,11-13H,8H2,1-2H3,(H,17,19)(H,18,20)(H,21,22)/t11-,12-,13-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240251
PNG
(US9403843, 23a | US9403843, 23b)
Show SMILES CC(C)C[C@H](NC(=O)[C@H]1O[C@@H]1C(O)=O)C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C16H18F2N2O5/c1-7(2)6-10(19-15(22)12-13(25-12)16(23)24)14(21)20-11-8(17)4-3-5-9(11)18/h3-5,7,10,12-13H,6H2,1-2H3,(H,19,22)(H,20,21)(H,23,24)/t10-,12-,13-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240231
PNG
(US9403843, 26)
Show SMILES CC(C)C[C@H](NC(=O)C1O[C@@H]1C(O)=O)C(=O)NCCCCNC(=O)CCCCC1CCSS1
Show InChI InChI=1S/C22H37N3O6S2/c1-14(2)13-16(25-21(28)18-19(31-18)22(29)30)20(27)24-11-6-5-10-23-17(26)8-4-3-7-15-9-12-32-33-15/h14-16,18-19H,3-13H2,1-2H3,(H,23,26)(H,24,27)(H,25,28)(H,29,30)/t15?,16-,18?,19-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM50437948
PNG
(CHEMBL2408899 | US9403843, 50)
Show SMILES OC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](Cc1cscn1)C(=O)NCc1cn(nn1)-c1ccc(F)cc1
Show InChI InChI=1S/C19H17FN6O5S/c20-10-1-3-13(4-2-10)26-7-12(24-25-26)6-21-17(27)14(5-11-8-32-9-22-11)23-18(28)15-16(31-15)19(29)30/h1-4,7-9,14-16H,5-6H2,(H,21,27)(H,23,28)(H,29,30)/t14-,15-,16-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM50437948
PNG
(CHEMBL2408899 | US9403843, 50)
Show SMILES OC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](Cc1cscn1)C(=O)NCc1cn(nn1)-c1ccc(F)cc1
Show InChI InChI=1S/C19H17FN6O5S/c20-10-1-3-13(4-2-10)26-7-12(24-25-26)6-21-17(27)14(5-11-8-32-9-22-11)23-18(28)15-16(31-15)19(29)30/h1-4,7-9,14-16H,5-6H2,(H,21,27)(H,23,28)(H,29,30)/t14-,15-,16-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240238
PNG
(US9403843, 25)
Show SMILES CC(C)C[C@H](NC(=O)C1O[C@@H]1C(O)=O)C(=O)NCCCCNS(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C20H28FN3O7S/c1-12(2)11-15(24-19(26)16-17(31-16)20(27)28)18(25)22-9-3-4-10-23-32(29,30)14-7-5-13(21)6-8-14/h5-8,12,15-17,23H,3-4,9-11H2,1-2H3,(H,22,25)(H,24,26)(H,27,28)/t15-,16?,17-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240231
PNG
(US9403843, 26)
Show SMILES CC(C)C[C@H](NC(=O)C1O[C@@H]1C(O)=O)C(=O)NCCCCNC(=O)CCCCC1CCSS1
Show InChI InChI=1S/C22H37N3O6S2/c1-14(2)13-16(25-21(28)18-19(31-18)22(29)30)20(27)24-11-6-5-10-23-17(26)8-4-3-7-15-9-12-32-33-15/h14-16,18-19H,3-13H2,1-2H3,(H,23,26)(H,24,27)(H,25,28)(H,29,30)/t15?,16-,18?,19-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240233
PNG
(US9403843, 27)
Show SMILES CC(C)C[C@H](NC(=O)C1O[C@@H]1C(O)=O)C(=O)NCCCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12
Show InChI InChI=1S/C24H39N5O7S/c1-13(2)11-14(27-22(32)19-20(36-19)23(33)34)21(31)26-10-6-5-9-25-17(30)8-4-3-7-16-18-15(12-37-16)28-24(35)29-18/h13-16,18-20H,3-12H2,1-2H3,(H,25,30)(H,26,31)(H,27,32)(H,33,34)(H2,28,29,35)/t14-,15-,16-,18-,19?,20-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240242
PNG
(US9403843, 67)
Show SMILES CC(C)C[C@H](NC(=O)[C@H]1O[C@@H]1C(O)=O)C(=O)NCCCCNC(=O)CCCCC1CCSS1
Show InChI InChI=1S/C22H37N3O6S2/c1-14(2)13-16(25-21(28)18-19(31-18)22(29)30)20(27)24-11-6-5-10-23-17(26)8-4-3-7-15-9-12-32-33-15/h14-16,18-19H,3-13H2,1-2H3,(H,23,26)(H,24,27)(H,25,28)(H,29,30)/t15?,16-,18-,19-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM62323
PNG
(US9403843, 24b)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H]1O[C@H]1C(O)=O)C(=O)Nc1nc(cs1)-c1ccc(F)cc1
Show InChI InChI=1S/C19H20FN3O5S/c1-9(2)7-12(21-17(25)14-15(28-14)18(26)27)16(24)23-19-22-13(8-29-19)10-3-5-11(20)6-4-10/h3-6,8-9,12,14-15H,7H2,1-2H3,(H,21,25)(H,26,27)(H,22,23,24)/t12-,14+,15+/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240247
PNG
(US9403843, 72)
Show SMILES CC(C)C[C@H](NC(=O)[C@H]1O[C@@H]1C(O)=O)C(=O)N(C)c1nc(cs1)-c1ccc(F)cc1
Show InChI InChI=1S/C20H22FN3O5S/c1-10(2)8-13(22-17(25)15-16(29-15)19(27)28)18(26)24(3)20-23-14(9-30-20)11-4-6-12(21)7-5-11/h4-7,9-10,13,15-16H,8H2,1-3H3,(H,22,25)(H,27,28)/t13-,15-,16-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240259
PNG
(US9403843, 36)
Show SMILES Cn1cnc(C[C@H](NC(=O)[C@H]2O[C@@H]2C(O)=O)C(=O)Nc2nc(cs2)-c2ccc(F)cc2)c1
Show InChI InChI=1S/C20H18FN5O5S/c1-26-7-12(22-9-26)6-13(23-18(28)15-16(31-15)19(29)30)17(27)25-20-24-14(8-32-20)10-2-4-11(21)5-3-10/h2-5,7-9,13,15-16H,6H2,1H3,(H,23,28)(H,29,30)(H,24,25,27)/t13-,15-,16-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM50437951
PNG
(CHEMBL2408922 | US9403843, 24a)
Show SMILES CC(C)C[C@H](NC(=O)[C@H]1O[C@@H]1C(O)=O)C(=O)Nc1nc(cs1)-c1ccc(F)cc1
Show InChI InChI=1S/C19H20FN3O5S/c1-9(2)7-12(21-17(25)14-15(28-14)18(26)27)16(24)23-19-22-13(8-29-19)10-3-5-11(20)6-4-10/h3-6,8-9,12,14-15H,7H2,1-2H3,(H,21,25)(H,26,27)(H,22,23,24)/t12-,14-,15-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240266
PNG
(US9403843, 88)
Show SMILES CC(C)C[C@H](NC(=O)[C@H]1O[C@@H]1C(O)=O)C(=O)NCC#C
Show InChI InChI=1S/C13H18N2O5/c1-4-5-14-11(16)8(6-7(2)3)15-12(17)9-10(20-9)13(18)19/h1,7-10H,5-6H2,2-3H3,(H,14,16)(H,15,17)(H,18,19)/t8-,9-,10-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240273
PNG
(US9403843, 56)
Show SMILES OC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](Cc1cscn1)C(=O)NCc1cn(nn1)-c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C19H17N7O7S/c27-17(14(5-10-8-34-9-21-10)22-18(28)15-16(33-15)19(29)30)20-6-11-7-25(24-23-11)12-1-3-13(4-2-12)26(31)32/h1-4,7-9,14-16H,5-6H2,(H,20,27)(H,22,28)(H,29,30)/t14-,15-,16-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240269
PNG
(US9403843, 52)
Show SMILES OC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](Cc1cscn1)C(=O)NCc1cn(nn1)-c1ccc2OCOc2c1
Show InChI InChI=1S/C20H18N6O7S/c27-18(13(3-10-7-34-8-22-10)23-19(28)16-17(33-16)20(29)30)21-5-11-6-26(25-24-11)12-1-2-14-15(4-12)32-9-31-14/h1-2,4,6-8,13,16-17H,3,5,9H2,(H,21,27)(H,23,28)(H,29,30)/t13-,16-,17-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240263
PNG
(US9403843, 31a)
Show SMILES OC(=O)[C@H]1O[C@H]1C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)Nc1nc2ccc(F)cc2s1
Show InChI InChI=1S/C17H14FN5O5S/c18-7-1-2-9-11(3-7)29-17(22-9)23-14(24)10(4-8-5-19-6-20-8)21-15(25)12-13(28-12)16(26)27/h1-3,5-6,10,12-13H,4H2,(H,19,20)(H,21,25)(H,26,27)(H,22,23,24)/t10-,12+,13-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240263
PNG
(US9403843, 31a)
Show SMILES OC(=O)[C@H]1O[C@H]1C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)Nc1nc2ccc(F)cc2s1
Show InChI InChI=1S/C17H14FN5O5S/c18-7-1-2-9-11(3-7)29-17(22-9)23-14(24)10(4-8-5-19-6-20-8)21-15(25)12-13(28-12)16(26)27/h1-3,5-6,10,12-13H,4H2,(H,19,20)(H,21,25)(H,26,27)(H,22,23,24)/t10-,12+,13-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240252
PNG
(US9403843, 79 | US9403843, 82)
Show SMILES CCOC(=O)[C@H]1O[C@@H]1C(=O)NCc1ccc(CO)cc1
Show InChI InChI=1S/C14H17NO5/c1-2-19-14(18)12-11(20-12)13(17)15-7-9-3-5-10(8-16)6-4-9/h3-6,11-12,16H,2,7-8H2,1H3,(H,15,17)/t11-,12-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240285
PNG
(US9403843, 31b)
Show SMILES OC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)Nc1nc2ccc(F)cc2s1
Show InChI InChI=1S/C17H14FN5O5S/c18-7-1-2-9-11(3-7)29-17(22-9)23-14(24)10(4-8-5-19-6-20-8)21-15(25)12-13(28-12)16(26)27/h1-3,5-6,10,12-13H,4H2,(H,19,20)(H,21,25)(H,26,27)(H,22,23,24)/t10-,12-,13-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240237
PNG
(US9403843, 63)
Show SMILES CCOC(=O)[C@H]1OC1C(=O)N[C@@H](CC(C)C)C(=O)NCCCCNS(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C22H32FN3O7S/c1-4-32-22(29)19-18(33-19)21(28)26-17(13-14(2)3)20(27)24-11-5-6-12-25-34(30,31)16-9-7-15(23)8-10-16/h7-10,14,17-19,25H,4-6,11-13H2,1-3H3,(H,24,27)(H,26,28)/t17-,18?,19-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240240
PNG
(US9403843, 65)
Show SMILES CC(C)C[C@H](NC(=O)C1OC1c1ccccc1)C(=O)NCCCCNC(N)=N
Show InChI InChI=1S/C20H31N5O3/c1-13(2)12-15(18(26)23-10-6-7-11-24-20(21)22)25-19(27)17-16(28-17)14-8-4-3-5-9-14/h3-5,8-9,13,15-17H,6-7,10-12H2,1-2H3,(H,23,26)(H,25,27)(H4,21,22,24)/t15-,16?,17?/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240245
PNG
(US9403843, 70 | US9403843, 75)
Show SMILES CCOC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)Nc1nc(cs1)-c1ccc(F)cc1
Show InChI InChI=1S/C21H24FN3O5S/c1-4-29-20(28)17-16(30-17)19(27)23-14(9-11(2)3)18(26)25-21-24-15(10-31-21)12-5-7-13(22)8-6-12/h5-8,10-11,14,16-17H,4,9H2,1-3H3,(H,23,27)(H,24,25,26)/t14-,16-,17-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240279
PNG
(US9403843, 76)
Show SMILES CCOC(=O)[C@H]1O[C@@H]1C(N)=O
Show InChI InChI=1S/C6H9NO4/c1-2-10-6(9)4-3(11-4)5(7)8/h3-4H,2H2,1H3,(H2,7,8)/t3-,4-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240253
PNG
(US9403843, 83)
Show SMILES OCc1ccc(CNC(=O)[C@H]2O[C@@H]2C(O)=O)cc1
Show InChI InChI=1S/C12H13NO5/c14-6-8-3-1-7(2-4-8)5-13-11(15)9-10(18-9)12(16)17/h1-4,9-10,14H,5-6H2,(H,13,15)(H,16,17)/t9-,10-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240248
PNG
(US9403843, 77 | US9403843, 78)
Show SMILES CCOC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)Nc1nc(cs1)-c1ccc(F)cc1
Show InChI InChI=1S/C21H20FN5O5S/c1-2-31-20(30)17-16(32-17)19(29)25-14(7-13-8-23-10-24-13)18(28)27-21-26-15(9-33-21)11-3-5-12(22)6-4-11/h3-6,8-10,14,16-17H,2,7H2,1H3,(H,23,24)(H,25,29)(H,26,27,28)/t14-,16-,17-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240236
PNG
(US9403843, 62)
Show SMILES CC(C)C[C@H](NC(=O)C1OC1c1ccccc1)C(=O)NCCCCNC(=O)CCCCC1CCSS1
Show InChI InChI=1S/C27H41N3O4S2/c1-19(2)18-22(30-27(33)25-24(34-25)20-10-4-3-5-11-20)26(32)29-16-9-8-15-28-23(31)13-7-6-12-21-14-17-35-36-21/h3-5,10-11,19,21-22,24-25H,6-9,12-18H2,1-2H3,(H,28,31)(H,29,32)(H,30,33)/t21?,22-,24?,25?/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240251
PNG
(US9403843, 23a | US9403843, 23b)
Show SMILES CC(C)C[C@H](NC(=O)[C@H]1O[C@@H]1C(O)=O)C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C16H18F2N2O5/c1-7(2)6-10(19-15(22)12-13(25-12)16(23)24)14(21)20-11-8(17)4-3-5-9(11)18/h3-5,7,10,12-13H,6H2,1-2H3,(H,19,22)(H,20,21)(H,23,24)/t10-,12-,13-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240250
PNG
(US9403843, 80 | US9403843, 81)
Show SMILES CCOC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C18H22F2N2O5/c1-4-26-18(25)15-14(27-15)17(24)21-12(8-9(2)3)16(23)22-13-10(19)6-5-7-11(13)20/h5-7,9,12,14-15H,4,8H2,1-3H3,(H,21,24)(H,22,23)/t12-,14-,15-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240275
PNG
(US9403843, 58)
Show SMILES Cc1cc(C)c(c(C)c1)-n1cc(CNC(=O)[C@H](Cc2cscn2)NC(=O)[C@H]2O[C@@H]2C(O)=O)nn1
Show InChI InChI=1S/C22H24N6O5S/c1-11-4-12(2)17(13(3)5-11)28-8-15(26-27-28)7-23-20(29)16(6-14-9-34-10-24-14)25-21(30)18-19(33-18)22(31)32/h4-5,8-10,16,18-19H,6-7H2,1-3H3,(H,23,29)(H,25,30)(H,31,32)/t16-,18-,19-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240271
PNG
(US9403843, 54)
Show SMILES OC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](Cc1cscn1)C(=O)NCc1cn(nn1)-c1cc(cc(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C21H16F6N6O5S/c22-20(23,24)9-1-10(21(25,26)27)3-13(2-9)33-6-12(31-32-33)5-28-17(34)14(4-11-7-39-8-29-11)30-18(35)15-16(38-15)19(36)37/h1-3,6-8,14-16H,4-5H2,(H,28,34)(H,30,35)(H,36,37)/t14-,15-,16-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240267
PNG
(US9403843, 49)
Show SMILES OC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](Cc1cscn1)C(=O)NCc1cn(nn1)-c1ccccc1
Show InChI InChI=1S/C19H18N6O5S/c26-17(20-7-12-8-25(24-23-12)13-4-2-1-3-5-13)14(6-11-9-31-10-21-11)22-18(27)15-16(30-15)19(28)29/h1-5,8-10,14-16H,6-7H2,(H,20,26)(H,22,27)(H,28,29)/t14-,15-,16-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240277
PNG
(US9403843, 74)
Show SMILES CC(C)NC(=O)[C@H]1O[C@@H]1C(O)=O
Show InChI InChI=1S/C7H11NO4/c1-3(2)8-6(9)4-5(12-4)7(10)11/h3-5H,1-2H3,(H,8,9)(H,10,11)/t4-,5-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240241
PNG
(US9403843, 66)
Show SMILES OC(=O)[C@H]1O[C@@H]1C(=O)NC1(CCCCC1)C(=O)NCCCCNS(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C21H28FN3O7S/c22-14-6-8-15(9-7-14)33(30,31)24-13-5-4-12-23-20(29)21(10-2-1-3-11-21)25-18(26)16-17(32-16)19(27)28/h6-9,16-17,24H,1-5,10-13H2,(H,23,29)(H,25,26)(H,27,28)/t16-,17-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240234
PNG
(US9403843, 60)
Show SMILES CC(C)C[C@H](NC(=O)C1OC1c1ccccc1)C(=O)NCC#C
Show InChI InChI=1S/C18H22N2O3/c1-4-10-19-17(21)14(11-12(2)3)20-18(22)16-15(23-16)13-8-6-5-7-9-13/h1,5-9,12,14-16H,10-11H2,2-3H3,(H,19,21)(H,20,22)/t14-,15?,16?/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240250
PNG
(US9403843, 80 | US9403843, 81)
Show SMILES CCOC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C18H22F2N2O5/c1-4-26-18(25)15-14(27-15)17(24)21-12(8-9(2)3)16(23)22-13-10(19)6-5-7-11(13)20/h5-7,9,12,14-15H,4,8H2,1-3H3,(H,21,24)(H,22,23)/t12-,14-,15-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240246
PNG
(US9403843, 71)
Show SMILES CCOC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N(C)c1nc(cs1)-c1ccc(F)cc1
Show InChI InChI=1S/C22H26FN3O5S/c1-5-30-21(29)18-17(31-18)19(27)24-15(10-12(2)3)20(28)26(4)22-25-16(11-32-22)13-6-8-14(23)9-7-13/h6-9,11-12,15,17-18H,5,10H2,1-4H3,(H,24,27)/t15-,17-,18-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240230
PNG
(US9403843, 59)
Show SMILES CCOC(=O)[C@H]1OC1C(=O)N[C@@H](CC(C)C)C(=O)NCCCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12
Show InChI InChI=1S/C26H43N5O7S/c1-4-37-25(35)22-21(38-22)24(34)29-16(13-15(2)3)23(33)28-12-8-7-11-27-19(32)10-6-5-9-18-20-17(14-39-18)30-26(36)31-20/h15-18,20-22H,4-14H2,1-3H3,(H,27,32)(H,28,33)(H,29,34)(H2,30,31,36)/t16-,17-,18-,20-,21?,22-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240276
PNG
(US9403843, 73)
Show SMILES CCOC(=O)[C@H]1O[C@@H]1C(=O)NC(C)C
Show InChI InChI=1S/C9H15NO4/c1-4-13-9(12)7-6(14-7)8(11)10-5(2)3/h5-7H,4H2,1-3H3,(H,10,11)/t6-,7-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240248
PNG
(US9403843, 77 | US9403843, 78)
Show SMILES CCOC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)Nc1nc(cs1)-c1ccc(F)cc1
Show InChI InChI=1S/C21H20FN5O5S/c1-2-31-20(30)17-16(32-17)19(29)25-14(7-13-8-23-10-24-13)18(28)27-21-26-15(9-33-21)11-3-5-12(22)6-4-11/h3-6,8-10,14,16-17H,2,7H2,1H3,(H,23,24)(H,25,29)(H,26,27,28)/t14-,16-,17-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240270
PNG
(US9403843, 53)
Show SMILES NS(=O)(=O)c1ccc(cc1)-n1cc(CNC(=O)[C@H](Cc2cscn2)NC(=O)[C@H]2O[C@@H]2C(O)=O)nn1
Show InChI InChI=1S/C19H19N7O7S2/c20-35(31,32)13-3-1-12(2-4-13)26-7-11(24-25-26)6-21-17(27)14(5-10-8-34-9-22-10)23-18(28)15-16(33-15)19(29)30/h1-4,7-9,14-16H,5-6H2,(H,21,27)(H,23,28)(H,29,30)(H2,20,31,32)/t14-,15-,16-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240252
PNG
(US9403843, 79 | US9403843, 82)
Show SMILES CCOC(=O)[C@H]1O[C@@H]1C(=O)NCc1ccc(CO)cc1
Show InChI InChI=1S/C14H17NO5/c1-2-19-14(18)12-11(20-12)13(17)15-7-9-3-5-10(8-16)6-4-9/h3-6,11-12,16H,2,7-8H2,1H3,(H,15,17)/t11-,12-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240245
PNG
(US9403843, 70 | US9403843, 75)
Show SMILES CCOC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)Nc1nc(cs1)-c1ccc(F)cc1
Show InChI InChI=1S/C21H24FN3O5S/c1-4-29-20(28)17-16(30-17)19(27)23-14(9-11(2)3)18(26)25-21-24-15(10-31-21)12-5-7-13(22)8-6-12/h5-8,10-11,14,16-17H,4,9H2,1-3H3,(H,23,27)(H,24,25,26)/t14-,16-,17-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240281
PNG
(US9403843, 30b)
Show SMILES OC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)Nc1nc(cs1)-c1ccc(F)cc1
Show InChI InChI=1S/C19H16FN5O5S/c20-10-3-1-9(2-4-10)13-7-31-19(24-13)25-16(26)12(5-11-6-21-8-22-11)23-17(27)14-15(30-14)18(28)29/h1-4,6-8,12,14-15H,5H2,(H,21,22)(H,23,27)(H,28,29)(H,24,25,26)/t12-,14-,15-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240244
PNG
(US9403843, 69)
Show SMILES CCOC(=O)[C@H]1O[C@@H]1C(=O)NC1(CCCCC1)C(=O)NCCCCNS(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C23H32FN3O7S/c1-2-33-21(29)19-18(34-19)20(28)27-23(12-4-3-5-13-23)22(30)25-14-6-7-15-26-35(31,32)17-10-8-16(24)9-11-17/h8-11,18-19,26H,2-7,12-15H2,1H3,(H,25,30)(H,27,28)/t18-,19-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240235
PNG
(US9403843, 61)
Show SMILES CC(C)C[C@H](NC(=O)C1OC1c1ccccc1)C(=O)NCCCCNC(C)=O
Show InChI InChI=1S/C21H31N3O4/c1-14(2)13-17(20(26)23-12-8-7-11-22-15(3)25)24-21(27)19-18(28-19)16-9-5-4-6-10-16/h4-6,9-10,14,17-19H,7-8,11-13H2,1-3H3,(H,22,25)(H,23,26)(H,24,27)/t17-,18?,19?/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240274
PNG
(US9403843, 57)
Show SMILES OC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](Cc1cscn1)C(=O)NCc1cn(nn1)-c1c(F)cccc1F
Show InChI InChI=1S/C19H16F2N6O5S/c20-11-2-1-3-12(21)14(11)27-6-10(25-26-27)5-22-17(28)13(4-9-7-33-8-23-9)24-18(29)15-16(32-15)19(30)31/h1-3,6-8,13,15-16H,4-5H2,(H,22,28)(H,24,29)(H,30,31)/t13-,15-,16-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240268
PNG
(US9403843, 51)
Show SMILES OC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](Cc1cscn1)C(=O)NCc1cn(nn1)-c1ccc(cc1)S(=O)(=O)N1CCCCC1
Show InChI InChI=1S/C24H27N7O7S2/c32-22(19(10-15-13-39-14-26-15)27-23(33)20-21(38-20)24(34)35)25-11-16-12-31(29-28-16)17-4-6-18(7-5-17)40(36,37)30-8-2-1-3-9-30/h4-7,12-14,19-21H,1-3,8-11H2,(H,25,32)(H,27,33)(H,34,35)/t19-,20-,21-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240254
PNG
(US9403843, 84)
Show SMILES CCOC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)Nc1ccccc1
Show InChI InChI=1S/C18H24N2O5/c1-4-24-18(23)15-14(25-15)17(22)20-13(10-11(2)3)16(21)19-12-8-6-5-7-9-12/h5-9,11,13-15H,4,10H2,1-3H3,(H,19,21)(H,20,22)/t13-,14-,15-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240261
PNG
(US9403843, 32)
Show SMILES OC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](Cc1cscn1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C16H15N3O5S/c20-14(18-9-4-2-1-3-5-9)11(6-10-7-25-8-17-10)19-15(21)12-13(24-12)16(22)23/h1-5,7-8,11-13H,6H2,(H,18,20)(H,19,21)(H,22,23)/t11-,12-,13-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240257
PNG
(US9403843, 28)
Show SMILES OC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C16H16N4O5/c21-14(19-9-4-2-1-3-5-9)11(6-10-7-17-8-18-10)20-15(22)12-13(25-12)16(23)24/h1-5,7-8,11-13H,6H2,(H,17,18)(H,19,21)(H,20,22)(H,23,24)/t11-,12-,13-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240260
PNG
(US9403843, 29)
Show SMILES Cc1cc(C)c(NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]2O[C@@H]2C(O)=O)c(C)c1
Show InChI InChI=1S/C19H22N4O5/c1-9-4-10(2)14(11(3)5-9)23-17(24)13(6-12-7-20-8-21-12)22-18(25)15-16(28-15)19(26)27/h4-5,7-8,13,15-16H,6H2,1-3H3,(H,20,21)(H,22,25)(H,23,24)(H,26,27)/t13-,15-,16-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240258
PNG
(US9403843, 35)
Show SMILES Cn1cncc1C[C@H](NC(=O)[C@H]1O[C@@H]1C(O)=O)C(=O)Nc1nc(cs1)-c1ccc(F)cc1
Show InChI InChI=1S/C20H18FN5O5S/c1-26-9-22-7-12(26)6-13(23-18(28)15-16(31-15)19(29)30)17(27)25-20-24-14(8-32-20)10-2-4-11(21)5-3-10/h2-5,7-9,13,15-16H,6H2,1H3,(H,23,28)(H,29,30)(H,24,25,27)/t13-,15-,16-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM240256
PNG
(US9403843, 85)
Show SMILES CCOC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C18H20N4O5/c1-2-26-18(25)15-14(27-15)17(24)22-13(8-12-9-19-10-20-12)16(23)21-11-6-4-3-5-7-11/h3-7,9-10,13-15H,2,8H2,1H3,(H,19,20)(H,21,23)(H,22,24)/t13-,14-,15-/m0/s1
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

US Patent


Assay Description
The Calbiochem InnoZyme activity kit was used for measuring the inhibition effect inhibitors on human erythrocyte calpain 1 activity. A calpain FRET ...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%