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Patent code US9408850

Compile Data Set for Download or QSAR
Found 74 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))
BDBM239033
PNG
(US9408850, 19)
Show SMILES CN1CCC(CC1)Nc1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12
Show InChI InChI=1S/C29H33N5O3/c1-34-15-13-24(14-16-34)30-23-9-7-22(8-10-23)29(35)31-28-26-12-11-25(19-27(26)32-33-28)37-18-17-36-20-21-5-3-2-4-6-21/h2-12,19,24,30H,13-18,20H2,1H3,(H2,31,32,33,35)
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n/an/a<50n/an/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was pre activat...


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))
BDBM239042
PNG
(US9408850, 42)
Show SMILES C[N+]1([O-])CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccc(cc3)C(F)(F)F)ccc12
Show InChI InChI=1S/C29H30F3N5O4/c1-37(39)14-12-36(13-15-37)23-8-4-21(5-9-23)28(38)33-27-25-11-10-24(18-26(25)34-35-27)41-17-16-40-19-20-2-6-22(7-3-20)29(30,31)32/h2-11,18H,12-17,19H2,1H3,(H2,33,34,35,38)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was pre activat...


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))
BDBM239026
PNG
(US9408850, 40)
Show SMILES COc1ccc(COCCOc2ccc3c(NC(=O)c4ccc(cc4)N4CCN(C)CC4)n[nH]c3c2)cc1
Show InChI InChI=1S/C29H33N5O4/c1-33-13-15-34(16-14-33)23-7-5-22(6-8-23)29(35)30-28-26-12-11-25(19-27(26)31-32-28)38-18-17-37-20-21-3-9-24(36-2)10-4-21/h3-12,19H,13-18,20H2,1-2H3,(H2,30,31,32,35)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was pre activat...


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))
BDBM239038
PNG
(US9408850, 27)
Show SMILES CN1CCC(CNc2ccc(cc2)C(=O)Nc2n[nH]c3cc(OCCOCc4ccccc4)ccc23)CC1
Show InChI InChI=1S/C30H35N5O3/c1-35-15-13-22(14-16-35)20-31-25-9-7-24(8-10-25)30(36)32-29-27-12-11-26(19-28(27)33-34-29)38-18-17-37-21-23-5-3-2-4-6-23/h2-12,19,22,31H,13-18,20-21H2,1H3,(H2,32,33,34,36)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was pre activat...


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))
BDBM239040
PNG
(US9408850, 14)
Show SMILES C[N+]1([O-])CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12
Show InChI InChI=1S/C28H31N5O4/c1-33(35)15-13-32(14-16-33)23-9-7-22(8-10-23)28(34)29-27-25-12-11-24(19-26(25)30-31-27)37-18-17-36-20-21-5-3-2-4-6-21/h2-12,19H,13-18,20H2,1H3,(H2,29,30,31,34)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was pre activat...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit


(Homo sapiens (Human))
BDBM239023
PNG
(US9408850, 32)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccc(F)cc3)ccc12
Show InChI InChI=1S/C28H30FN5O3/c1-33-12-14-34(15-13-33)23-8-4-21(5-9-23)28(35)30-27-25-11-10-24(18-26(25)31-32-27)37-17-16-36-19-20-2-6-22(29)7-3-20/h2-11,18H,12-17,19H2,1H3,(H2,30,31,32,35)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit


(Homo sapiens (Human))
BDBM239022
PNG
(US9408850, 33)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccc(cc3)C(F)(F)F)ccc12
Show InChI InChI=1S/C29H30F3N5O3/c1-36-12-14-37(15-13-36)23-8-4-21(5-9-23)28(38)33-27-25-11-10-24(18-26(25)34-35-27)40-17-16-39-19-20-2-6-22(7-3-20)29(30,31)32/h2-11,18H,12-17,19H2,1H3,(H2,33,34,35,38)
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NERVIANO MEDICAL SCIENCES S.R.L.

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Assay Description
The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))
BDBM239022
PNG
(US9408850, 33)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccc(cc3)C(F)(F)F)ccc12
Show InChI InChI=1S/C29H30F3N5O3/c1-36-12-14-37(15-13-36)23-8-4-21(5-9-23)28(38)33-27-25-11-10-24(18-26(25)34-35-27)40-17-16-39-19-20-2-6-22(7-3-20)29(30,31)32/h2-11,18H,12-17,19H2,1H3,(H2,33,34,35,38)
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NERVIANO MEDICAL SCIENCES S.R.L.

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Assay Description
The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was pre activat...


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))
BDBM239030
PNG
(US9408850, 16)
Show SMILES CN(C)CCN(C)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12
Show InChI InChI=1S/C28H33N5O3/c1-32(2)15-16-33(3)23-11-9-22(10-12-23)28(34)29-27-25-14-13-24(19-26(25)30-31-27)36-18-17-35-20-21-7-5-4-6-8-21/h4-14,19H,15-18,20H2,1-3H3,(H2,29,30,31,34)
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NERVIANO MEDICAL SCIENCES S.R.L.

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Assay Description
The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was pre activat...


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))
BDBM239043
PNG
(US9408850, 20)
Show SMILES O=C(Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12)c1ccc(cc1)N1CCNCC1
Show InChI InChI=1S/C27H29N5O3/c33-27(21-6-8-22(9-7-21)32-14-12-28-13-15-32)29-26-24-11-10-23(18-25(24)30-31-26)35-17-16-34-19-20-4-2-1-3-5-20/h1-11,18,28H,12-17,19H2,(H2,29,30,31,33)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was pre activat...


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))
BDBM239029
PNG
(US9408850, 15)
Show SMILES CN(C)C1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12
Show InChI InChI=1S/C30H35N5O3/c1-34(2)24-14-16-35(17-15-24)25-10-8-23(9-11-25)30(36)31-29-27-13-12-26(20-28(27)32-33-29)38-19-18-37-21-22-6-4-3-5-7-22/h3-13,20,24H,14-19,21H2,1-2H3,(H2,31,32,33,36)
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NERVIANO MEDICAL SCIENCES S.R.L.

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Assay Description
The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was pre activat...


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))
BDBM239017
PNG
(US9408850, 11)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12
Show InChI InChI=1S/C28H31N5O3/c1-32-13-15-33(16-14-32)23-9-7-22(8-10-23)28(34)29-27-25-12-11-24(19-26(25)30-31-27)36-18-17-35-20-21-5-3-2-4-6-21/h2-12,19H,13-18,20H2,1H3,(H2,29,30,31,34)
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NERVIANO MEDICAL SCIENCES S.R.L.

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Assay Description
The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was pre activat...


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))
BDBM239012
PNG
(US9408850, 10)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOc3ccccc3)ccc12
Show InChI InChI=1S/C27H29N5O3/c1-31-13-15-32(16-14-31)21-9-7-20(8-10-21)27(33)28-26-24-12-11-23(19-25(24)29-30-26)35-18-17-34-22-5-3-2-4-6-22/h2-12,19H,13-18H2,1H3,(H2,28,29,30,33)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was pre activat...


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))
BDBM239034
PNG
(US9408850, 23)
Show SMILES CN(C1CCN(C)CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12
Show InChI InChI=1S/C30H35N5O3/c1-34-16-14-25(15-17-34)35(2)24-10-8-23(9-11-24)30(36)31-29-27-13-12-26(20-28(27)32-33-29)38-19-18-37-21-22-6-4-3-5-7-22/h3-13,20,25H,14-19,21H2,1-2H3,(H2,31,32,33,36)
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NERVIANO MEDICAL SCIENCES S.R.L.

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Assay Description
The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was pre activat...


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))
BDBM239023
PNG
(US9408850, 32)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccc(F)cc3)ccc12
Show InChI InChI=1S/C28H30FN5O3/c1-33-12-14-34(15-13-33)23-8-4-21(5-9-23)28(35)30-27-25-11-10-24(18-26(25)31-32-27)37-17-16-36-19-20-2-6-22(29)7-3-20/h2-11,18H,12-17,19H2,1H3,(H2,30,31,32,35)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was pre activat...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit


(Homo sapiens (Human))
BDBM239043
PNG
(US9408850, 20)
Show SMILES O=C(Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12)c1ccc(cc1)N1CCNCC1
Show InChI InChI=1S/C27H29N5O3/c33-27(21-6-8-22(9-7-21)32-14-12-28-13-15-32)29-26-24-11-10-23(18-25(24)30-31-26)35-17-16-34-19-20-4-2-1-3-5-20/h1-11,18,28H,12-17,19H2,(H2,29,30,31,33)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))
BDBM239041
PNG
(US9408850, 41)
Show SMILES CN(C1CC[N+](C)([O-])CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12
Show InChI InChI=1S/C30H35N5O4/c1-34(25-14-16-35(2,37)17-15-25)24-10-8-23(9-11-24)30(36)31-29-27-13-12-26(20-28(27)32-33-29)39-19-18-38-21-22-6-4-3-5-7-22/h3-13,20,25H,14-19,21H2,1-2H3,(H2,31,32,33,36)
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NERVIANO MEDICAL SCIENCES S.R.L.

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Assay Description
The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was pre activat...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit


(Homo sapiens (Human))
BDBM239019
PNG
(US9408850, 22)
Show SMILES CN1CCC(CC1)Oc1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12
Show InChI InChI=1S/C29H32N4O4/c1-33-15-13-24(14-16-33)37-23-9-7-22(8-10-23)29(34)30-28-26-12-11-25(19-27(26)31-32-28)36-18-17-35-20-21-5-3-2-4-6-21/h2-12,19,24H,13-18,20H2,1H3,(H2,30,31,32,34)
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Assay Description
The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit


(Homo sapiens (Human))
BDBM239042
PNG
(US9408850, 42)
Show SMILES C[N+]1([O-])CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccc(cc3)C(F)(F)F)ccc12
Show InChI InChI=1S/C29H30F3N5O4/c1-37(39)14-12-36(13-15-37)23-8-4-21(5-9-23)28(38)33-27-25-11-10-24(18-26(25)34-35-27)41-17-16-40-19-20-2-6-22(7-3-20)29(30,31)32/h2-11,18H,12-17,19H2,1H3,(H2,33,34,35,38)
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NERVIANO MEDICAL SCIENCES S.R.L.

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Assay Description
The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))
BDBM239024
PNG
(US9408850, 34)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3cccc(c3)C(F)(F)F)ccc12
Show InChI InChI=1S/C29H30F3N5O3/c1-36-11-13-37(14-12-36)23-7-5-21(6-8-23)28(38)33-27-25-10-9-24(18-26(25)34-35-27)40-16-15-39-19-20-3-2-4-22(17-20)29(30,31)32/h2-10,17-18H,11-16,19H2,1H3,(H2,33,34,35,38)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was pre activat...


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))
BDBM239019
PNG
(US9408850, 22)
Show SMILES CN1CCC(CC1)Oc1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12
Show InChI InChI=1S/C29H32N4O4/c1-33-15-13-24(14-16-33)37-23-9-7-22(8-10-23)29(34)30-28-26-12-11-25(19-27(26)31-32-28)36-18-17-35-20-21-5-3-2-4-6-21/h2-12,19,24H,13-18,20H2,1H3,(H2,30,31,32,34)
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NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was pre activat...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit


(Homo sapiens (Human))
BDBM239024
PNG
(US9408850, 34)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3cccc(c3)C(F)(F)F)ccc12
Show InChI InChI=1S/C29H30F3N5O3/c1-36-11-13-37(14-12-36)23-7-5-21(6-8-23)28(38)33-27-25-10-9-24(18-26(25)34-35-27)40-16-15-39-19-20-3-2-4-22(17-20)29(30,31)32/h2-10,17-18H,11-16,19H2,1H3,(H2,33,34,35,38)
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Assay Description
The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit


(Homo sapiens (Human))
BDBM239033
PNG
(US9408850, 19)
Show SMILES CN1CCC(CC1)Nc1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12
Show InChI InChI=1S/C29H33N5O3/c1-34-15-13-24(14-16-34)30-23-9-7-22(8-10-23)29(35)31-28-26-12-11-25(19-27(26)32-33-28)37-18-17-36-20-21-5-3-2-4-6-21/h2-12,19,24,30H,13-18,20H2,1H3,(H2,31,32,33,35)
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Assay Description
The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...


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More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))
BDBM239031
PNG
(US9408850, 17)
Show SMILES CN(C)CCCN(C)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12
Show InChI InChI=1S/C29H35N5O3/c1-33(2)16-7-17-34(3)24-12-10-23(11-13-24)29(35)30-28-26-15-14-25(20-27(26)31-32-28)37-19-18-36-21-22-8-5-4-6-9-22/h4-6,8-15,20H,7,16-19,21H2,1-3H3,(H2,30,31,32,35)
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Assay Description
The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was pre activat...


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More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))
BDBM239028
PNG
(US9408850, 39)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OC\C=C\c3ccccc3)ccc12
Show InChI InChI=1S/C28H29N5O2/c1-32-15-17-33(18-16-32)23-11-9-22(10-12-23)28(34)29-27-25-14-13-24(20-26(25)30-31-27)35-19-5-8-21-6-3-2-4-7-21/h2-14,20H,15-19H2,1H3,(H2,29,30,31,34)/b8-5+
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Assay Description
The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was pre activat...


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More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))
BDBM239036
PNG
(US9408850, 25)
Show SMILES O=C(Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12)c1ccc(NCCN2CCOCC2)cc1
Show InChI InChI=1S/C29H33N5O4/c35-29(23-6-8-24(9-7-23)30-12-13-34-14-16-36-17-15-34)31-28-26-11-10-25(20-27(26)32-33-28)38-19-18-37-21-22-4-2-1-3-5-22/h1-11,20,30H,12-19,21H2,(H2,31,32,33,35)
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Assay Description
The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was pre activat...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit


(Homo sapiens (Human))
BDBM239029
PNG
(US9408850, 15)
Show SMILES CN(C)C1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12
Show InChI InChI=1S/C30H35N5O3/c1-34(2)24-14-16-35(17-15-24)25-10-8-23(9-11-25)30(36)31-29-27-13-12-26(20-28(27)32-33-29)38-19-18-37-21-22-6-4-3-5-7-22/h3-13,20,24H,14-19,21H2,1-2H3,(H2,31,32,33,36)
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Assay Description
The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit


(Homo sapiens (Human))
BDBM239026
PNG
(US9408850, 40)
Show SMILES COc1ccc(COCCOc2ccc3c(NC(=O)c4ccc(cc4)N4CCN(C)CC4)n[nH]c3c2)cc1
Show InChI InChI=1S/C29H33N5O4/c1-33-13-15-34(16-14-33)23-7-5-22(6-8-23)29(35)30-28-26-12-11-25(19-27(26)31-32-28)38-18-17-37-20-21-3-9-24(36-2)10-4-21/h3-12,19H,13-18,20H2,1-2H3,(H2,30,31,32,35)
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Assay Description
The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...


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More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))
BDBM239037
PNG
(US9408850, 26)
Show SMILES O=C(Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12)c1ccc(NC2CCOCC2)cc1
Show InChI InChI=1S/C28H30N4O4/c33-28(21-6-8-22(9-7-21)29-23-12-14-34-15-13-23)30-27-25-11-10-24(18-26(25)31-32-27)36-17-16-35-19-20-4-2-1-3-5-20/h1-11,18,23,29H,12-17,19H2,(H2,30,31,32,33)
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Assay Description
The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was pre activat...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit


(Homo sapiens (Human))
BDBM239038
PNG
(US9408850, 27)
Show SMILES CN1CCC(CNc2ccc(cc2)C(=O)Nc2n[nH]c3cc(OCCOCc4ccccc4)ccc23)CC1
Show InChI InChI=1S/C30H35N5O3/c1-35-15-13-22(14-16-35)20-31-25-9-7-24(8-10-25)30(36)32-29-27-12-11-26(19-28(27)33-34-29)38-18-17-37-21-23-5-3-2-4-6-23/h2-12,19,22,31H,13-18,20-21H2,1H3,(H2,32,33,34,36)
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Assay Description
The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...


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More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))
BDBM239018
PNG
(US9408850, 21)
Show SMILES CN(C)Cc1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12
Show InChI InChI=1S/C26H28N4O3/c1-30(2)17-19-8-10-21(11-9-19)26(31)27-25-23-13-12-22(16-24(23)28-29-25)33-15-14-32-18-20-6-4-3-5-7-20/h3-13,16H,14-15,17-18H2,1-2H3,(H2,27,28,29,31)
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Assay Description
The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was pre activat...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit


(Homo sapiens (Human))
BDBM239030
PNG
(US9408850, 16)
Show SMILES CN(C)CCN(C)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12
Show InChI InChI=1S/C28H33N5O3/c1-32(2)15-16-33(3)23-11-9-22(10-12-23)28(34)29-27-25-14-13-24(19-26(25)30-31-27)36-18-17-35-20-21-7-5-4-6-8-21/h4-14,19H,15-18,20H2,1-3H3,(H2,29,30,31,34)
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Assay Description
The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit


(Homo sapiens (Human))
BDBM239034
PNG
(US9408850, 23)
Show SMILES CN(C1CCN(C)CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12
Show InChI InChI=1S/C30H35N5O3/c1-34-16-14-25(15-17-34)35(2)24-10-8-23(9-11-24)30(36)31-29-27-13-12-26(20-28(27)32-33-29)38-19-18-37-21-22-6-4-3-5-7-22/h3-13,20,25H,14-19,21H2,1-2H3,(H2,31,32,33,36)
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Assay Description
The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit


(Homo sapiens (Human))
BDBM239017
PNG
(US9408850, 11)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12
Show InChI InChI=1S/C28H31N5O3/c1-32-13-15-33(16-14-32)23-9-7-22(8-10-23)28(34)29-27-25-12-11-24(19-26(25)30-31-27)36-18-17-35-20-21-5-3-2-4-6-21/h2-12,19H,13-18,20H2,1H3,(H2,29,30,31,34)
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Assay Description
The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit


(Homo sapiens (Human))
BDBM239040
PNG
(US9408850, 14)
Show SMILES C[N+]1([O-])CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12
Show InChI InChI=1S/C28H31N5O4/c1-33(35)15-13-32(14-16-33)23-9-7-22(8-10-23)28(34)29-27-25-12-11-24(19-26(25)30-31-27)37-18-17-36-20-21-5-3-2-4-6-21/h2-12,19H,13-18,20H2,1H3,(H2,29,30,31,34)
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Assay Description
The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit


(Homo sapiens (Human))
BDBM239037
PNG
(US9408850, 26)
Show SMILES O=C(Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12)c1ccc(NC2CCOCC2)cc1
Show InChI InChI=1S/C28H30N4O4/c33-28(21-6-8-22(9-7-21)29-23-12-14-34-15-13-23)30-27-25-11-10-24(18-26(25)31-32-27)36-17-16-35-19-20-4-2-1-3-5-20/h1-11,18,23,29H,12-17,19H2,(H2,30,31,32,33)
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Assay Description
The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit


(Homo sapiens (Human))
BDBM239018
PNG
(US9408850, 21)
Show SMILES CN(C)Cc1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12
Show InChI InChI=1S/C26H28N4O3/c1-30(2)17-19-8-10-21(11-9-19)26(31)27-25-23-13-12-22(16-24(23)28-29-25)33-15-14-32-18-20-6-4-3-5-7-20/h3-13,16H,14-15,17-18H2,1-2H3,(H2,27,28,29,31)
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Assay Description
The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...


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More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))
BDBM239039
PNG
(US9408850, 28)
Show SMILES O=C(Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12)c1ccc(cc1)N1CC(C1)N1CCCC1
Show InChI InChI=1S/C30H33N5O3/c36-30(23-8-10-24(11-9-23)35-19-25(20-35)34-14-4-5-15-34)31-29-27-13-12-26(18-28(27)32-33-29)38-17-16-37-21-22-6-2-1-3-7-22/h1-3,6-13,18,25H,4-5,14-17,19-21H2,(H2,31,32,33,36)
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Assay Description
The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was pre activat...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit


(Homo sapiens (Human))
BDBM239031
PNG
(US9408850, 17)
Show SMILES CN(C)CCCN(C)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12
Show InChI InChI=1S/C29H35N5O3/c1-33(2)16-7-17-34(3)24-12-10-23(11-13-24)29(35)30-28-26-15-14-25(20-27(26)31-32-28)37-19-18-36-21-22-8-5-4-6-9-22/h4-6,8-15,20H,7,16-19,21H2,1-3H3,(H2,30,31,32,35)
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Assay Description
The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...


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More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))
BDBM239035
PNG
(US9408850, 24)
Show SMILES O=C(Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12)c1ccc(cc1)N1CCOCC1
Show InChI InChI=1S/C27H28N4O4/c32-27(21-6-8-22(9-7-21)31-12-14-33-15-13-31)28-26-24-11-10-23(18-25(24)29-30-26)35-17-16-34-19-20-4-2-1-3-5-20/h1-11,18H,12-17,19H2,(H2,28,29,30,32)
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Assay Description
The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was pre activat...


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More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))
BDBM239025
PNG
(US9408850, 30)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3F)ccc12
Show InChI InChI=1S/C28H30FN5O3/c1-33-12-14-34(15-13-33)22-8-6-20(7-9-22)28(35)30-27-24-11-10-23(18-26(24)31-32-27)37-17-16-36-19-21-4-2-3-5-25(21)29/h2-11,18H,12-17,19H2,1H3,(H2,30,31,32,35)
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Assay Description
The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was pre activat...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit


(Homo sapiens (Human))
BDBM239013
PNG
(US9408850, 2)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(Oc3ccccc3)ccc12
Show InChI InChI=1S/C25H25N5O2/c1-29-13-15-30(16-14-29)19-9-7-18(8-10-19)25(31)26-24-22-12-11-21(17-23(22)27-28-24)32-20-5-3-2-4-6-20/h2-12,17H,13-16H2,1H3,(H2,26,27,28,31)
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Assay Description
The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit


(Homo sapiens (Human))
BDBM239041
PNG
(US9408850, 41)
Show SMILES CN(C1CC[N+](C)([O-])CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12
Show InChI InChI=1S/C30H35N5O4/c1-34(25-14-16-35(2,37)17-15-25)24-10-8-23(9-11-24)30(36)31-29-27-13-12-26(20-28(27)32-33-29)39-19-18-38-21-22-6-4-3-5-7-22/h3-13,20,25H,14-19,21H2,1-2H3,(H2,31,32,33,36)
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Assay Description
The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit


(Homo sapiens (Human))
BDBM239036
PNG
(US9408850, 25)
Show SMILES O=C(Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12)c1ccc(NCCN2CCOCC2)cc1
Show InChI InChI=1S/C29H33N5O4/c35-29(23-6-8-24(9-7-23)30-12-13-34-14-16-36-17-15-34)31-28-26-11-10-25(20-27(26)32-33-28)38-19-18-37-21-22-4-2-1-3-5-22/h1-11,20,30H,12-19,21H2,(H2,31,32,33,35)
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The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...


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Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))
BDBM239011
PNG
(US9408850, 6)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OC3CCN(Cc4ccccc4)CC3)ccc12
Show InChI InChI=1S/C31H36N6O2/c1-35-17-19-37(20-18-35)25-9-7-24(8-10-25)31(38)32-30-28-12-11-27(21-29(28)33-34-30)39-26-13-15-36(16-14-26)22-23-5-3-2-4-6-23/h2-12,21,26H,13-20,22H2,1H3,(H2,32,33,34,38)
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Assay Description
The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was pre activat...


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More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))
BDBM239010
PNG
(US9408850, 7)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCC#Cc3ccccc3)ccc12
Show InChI InChI=1S/C28H27N5O2/c1-32-15-17-33(18-16-32)23-11-9-22(10-12-23)28(34)29-27-25-14-13-24(20-26(25)30-31-27)35-19-5-8-21-6-3-2-4-7-21/h2-4,6-7,9-14,20H,15-19H2,1H3,(H2,29,30,31,34)
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Assay Description
The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was pre activat...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit


(Homo sapiens (Human))
BDBM239035
PNG
(US9408850, 24)
Show SMILES O=C(Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12)c1ccc(cc1)N1CCOCC1
Show InChI InChI=1S/C27H28N4O4/c32-27(21-6-8-22(9-7-21)31-12-14-33-15-13-31)28-26-24-11-10-23(18-25(24)29-30-26)35-17-16-34-19-20-4-2-1-3-5-20/h1-11,18H,12-17,19H2,(H2,28,29,30,32)
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Assay Description
The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit


(Homo sapiens (Human))
BDBM239039
PNG
(US9408850, 28)
Show SMILES O=C(Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12)c1ccc(cc1)N1CC(C1)N1CCCC1
Show InChI InChI=1S/C30H33N5O3/c36-30(23-8-10-24(11-9-23)35-19-25(20-35)34-14-4-5-15-34)31-29-27-13-12-26(18-28(27)32-33-29)38-17-16-37-21-22-6-2-1-3-7-22/h1-3,6-13,18,25H,4-5,14-17,19-21H2,(H2,31,32,33,36)
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Assay Description
The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...


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More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))
BDBM239032
PNG
(US9408850, 18)
Show SMILES CC(C)(C)OC(=O)N1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12
Show InChI InChI=1S/C32H37N5O5/c1-32(2,3)42-31(39)37-17-15-36(16-18-37)25-11-9-24(10-12-25)30(38)33-29-27-14-13-26(21-28(27)34-35-29)41-20-19-40-22-23-7-5-4-6-8-23/h4-14,21H,15-20,22H2,1-3H3,(H2,33,34,35,38)
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Assay Description
The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was pre activat...


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More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))
BDBM239009
PNG
(US9408850, 1)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCc3ccccc3)ccc12
Show InChI InChI=1S/C26H27N5O2/c1-30-13-15-31(16-14-30)21-9-7-20(8-10-21)26(32)27-25-23-12-11-22(17-24(23)28-29-25)33-18-19-5-3-2-4-6-19/h2-12,17H,13-16,18H2,1H3,(H2,27,28,29,32)
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Assay Description
The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was pre activat...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit


(Homo sapiens (Human))
BDBM239028
PNG
(US9408850, 39)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OC\C=C\c3ccccc3)ccc12
Show InChI InChI=1S/C28H29N5O2/c1-32-15-17-33(18-16-32)23-11-9-22(10-12-23)28(34)29-27-25-14-13-24(20-26(25)30-31-27)35-19-5-8-21-6-3-2-4-7-21/h2-14,20H,15-19H2,1H3,(H2,29,30,31,34)/b8-5+
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Assay Description
The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...


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More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))
BDBM239021
PNG
(US9408850, 38)
Show SMILES CN1CCN(CC1)c1ccc(C(=O)Nc2n[nH]c3cc(OCCOCc4ccccc4)ccc23)c(F)c1
Show InChI InChI=1S/C28H30FN5O3/c1-33-11-13-34(14-12-33)21-7-9-23(25(29)17-21)28(35)30-27-24-10-8-22(18-26(24)31-32-27)37-16-15-36-19-20-5-3-2-4-6-20/h2-10,17-18H,11-16,19H2,1H3,(H2,30,31,32,35)
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Assay Description
The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was pre activat...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit


(Homo sapiens (Human))
BDBM239014
PNG
(US9408850, 3)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(Oc3cccc(F)c3)ccc12
Show InChI InChI=1S/C25H24FN5O2/c1-30-11-13-31(14-12-30)19-7-5-17(6-8-19)25(32)27-24-22-10-9-21(16-23(22)28-29-24)33-20-4-2-3-18(26)15-20/h2-10,15-16H,11-14H2,1H3,(H2,27,28,29,32)
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Assay Description
The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit


(Homo sapiens (Human))
BDBM239021
PNG
(US9408850, 38)
Show SMILES CN1CCN(CC1)c1ccc(C(=O)Nc2n[nH]c3cc(OCCOCc4ccccc4)ccc23)c(F)c1
Show InChI InChI=1S/C28H30FN5O3/c1-33-11-13-34(14-12-33)21-7-9-23(25(29)17-21)28(35)30-27-24-10-8-22(18-26(24)31-32-27)37-16-15-36-19-20-5-3-2-4-6-20/h2-10,17-18H,11-16,19H2,1H3,(H2,30,31,32,35)
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Assay Description
The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...


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More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))
BDBM239020
PNG
(US9408850, 29)
Show SMILES CN1CCN(CC1)c1cccc(c1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12
Show InChI InChI=1S/C28H31N5O3/c1-32-12-14-33(15-13-32)23-9-5-8-22(18-23)28(34)29-27-25-11-10-24(19-26(25)30-31-27)36-17-16-35-20-21-6-3-2-4-7-21/h2-11,18-19H,12-17,20H2,1H3,(H2,29,30,31,34)
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Assay Description
The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was pre activat...


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More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))
BDBM239014
PNG
(US9408850, 3)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(Oc3cccc(F)c3)ccc12
Show InChI InChI=1S/C25H24FN5O2/c1-30-11-13-31(14-12-30)19-7-5-17(6-8-19)25(32)27-24-22-10-9-21(16-23(22)28-29-24)33-20-4-2-3-18(26)15-20/h2-10,15-16H,11-14H2,1H3,(H2,27,28,29,32)
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Assay Description
The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was pre activat...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit


(Homo sapiens (Human))
BDBM239016
PNG
(US9408850, 9)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(Oc3cccc(OCc4ccccc4)c3)ccc12
Show InChI InChI=1S/C32H31N5O3/c1-36-16-18-37(19-17-36)25-12-10-24(11-13-25)32(38)33-31-29-15-14-28(21-30(29)34-35-31)40-27-9-5-8-26(20-27)39-22-23-6-3-2-4-7-23/h2-15,20-21H,16-19,22H2,1H3,(H2,33,34,35,38)
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Assay Description
The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit


(Homo sapiens (Human))
BDBM239012
PNG
(US9408850, 10)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOc3ccccc3)ccc12
Show InChI InChI=1S/C27H29N5O3/c1-31-13-15-32(16-14-31)21-9-7-20(8-10-21)27(33)28-26-24-12-11-23(19-25(24)29-30-26)35-18-17-34-22-5-3-2-4-6-22/h2-12,19H,13-18H2,1H3,(H2,28,29,30,33)
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Assay Description
The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...


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More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))
BDBM239015
PNG
(US9408850, 4)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(Oc3ccc(OCc4ccccc4)cc3)ccc12
Show InChI InChI=1S/C32H31N5O3/c1-36-17-19-37(20-18-36)25-9-7-24(8-10-25)32(38)33-31-29-16-15-28(21-30(29)34-35-31)40-27-13-11-26(12-14-27)39-22-23-5-3-2-4-6-23/h2-16,21H,17-20,22H2,1H3,(H2,33,34,35,38)
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Assay Description
The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was pre activat...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit


(Homo sapiens (Human))
BDBM239020
PNG
(US9408850, 29)
Show SMILES CN1CCN(CC1)c1cccc(c1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12
Show InChI InChI=1S/C28H31N5O3/c1-32-12-14-33(15-13-32)23-9-5-8-22(18-23)28(34)29-27-25-11-10-24(19-26(25)30-31-27)36-17-16-35-20-21-6-3-2-4-7-21/h2-11,18-19H,12-17,20H2,1H3,(H2,29,30,31,34)
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Assay Description
The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...


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More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))
BDBM239013
PNG
(US9408850, 2)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(Oc3ccccc3)ccc12
Show InChI InChI=1S/C25H25N5O2/c1-29-13-15-30(16-14-29)19-9-7-18(8-10-19)25(31)26-24-22-12-11-21(17-23(22)27-28-24)32-20-5-3-2-4-6-20/h2-12,17H,13-16H2,1H3,(H2,26,27,28,31)
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Assay Description
The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was pre activat...


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More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))
BDBM239008
PNG
(US9408850, 5)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCc3cccc(Oc4ccccc4)c3)ccc12
Show InChI InChI=1S/C32H31N5O3/c1-36-16-18-37(19-17-36)25-12-10-24(11-13-25)32(38)33-31-29-15-14-27(21-30(29)34-35-31)39-22-23-6-5-9-28(20-23)40-26-7-3-2-4-8-26/h2-15,20-21H,16-19,22H2,1H3,(H2,33,34,35,38)
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Assay Description
The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was pre activat...


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More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))
BDBM239027
PNG
(US9408850, 35)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccncc3)ccc12
Show InChI InChI=1S/C27H30N6O3/c1-32-12-14-33(15-13-32)22-4-2-21(3-5-22)27(34)29-26-24-7-6-23(18-25(24)30-31-26)36-17-16-35-19-20-8-10-28-11-9-20/h2-11,18H,12-17,19H2,1H3,(H2,29,30,31,34)
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Assay Description
The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was pre activat...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit


(Homo sapiens (Human))
BDBM239032
PNG
(US9408850, 18)
Show SMILES CC(C)(C)OC(=O)N1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12
Show InChI InChI=1S/C32H37N5O5/c1-32(2,3)42-31(39)37-17-15-36(16-18-37)25-11-9-24(10-12-25)30(38)33-29-27-14-13-26(21-28(27)34-35-29)41-20-19-40-22-23-7-5-4-6-8-23/h4-14,21H,15-20,22H2,1-3H3,(H2,33,34,35,38)
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Assay Description
The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit


(Homo sapiens (Human))
BDBM239025
PNG
(US9408850, 30)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3F)ccc12
Show InChI InChI=1S/C28H30FN5O3/c1-33-12-14-34(15-13-33)22-8-6-20(7-9-22)28(35)30-27-24-11-10-23(18-26(24)31-32-27)37-17-16-36-19-21-4-2-3-5-25(21)29/h2-11,18H,12-17,19H2,1H3,(H2,30,31,32,35)
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Assay Description
The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...


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More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))
BDBM239016
PNG
(US9408850, 9)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(Oc3cccc(OCc4ccccc4)c3)ccc12
Show InChI InChI=1S/C32H31N5O3/c1-36-16-18-37(19-17-36)25-12-10-24(11-13-25)32(38)33-31-29-15-14-28(21-30(29)34-35-31)40-27-9-5-8-26(20-27)39-22-23-6-3-2-4-7-23/h2-15,20-21H,16-19,22H2,1H3,(H2,33,34,35,38)
PDB

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n/an/a 1.50E+3n/an/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was pre activat...


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More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit


(Homo sapiens (Human))
BDBM239010
PNG
(US9408850, 7)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCC#Cc3ccccc3)ccc12
Show InChI InChI=1S/C28H27N5O2/c1-32-15-17-33(18-16-32)23-11-9-22(10-12-23)28(34)29-27-25-14-13-24(20-26(25)30-31-27)35-19-5-8-21-6-3-2-4-7-21/h2-4,6-7,9-14,20H,15-19H2,1H3,(H2,29,30,31,34)
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n/an/a 1.51E+3n/an/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit


(Homo sapiens (Human))
BDBM239027
PNG
(US9408850, 35)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccncc3)ccc12
Show InChI InChI=1S/C27H30N6O3/c1-32-12-14-33(15-13-32)22-4-2-21(3-5-22)27(34)29-26-24-7-6-23(18-25(24)30-31-26)36-17-16-35-19-20-8-10-28-11-9-20/h2-11,18H,12-17,19H2,1H3,(H2,29,30,31,34)
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n/an/a 2.37E+3n/an/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit


(Homo sapiens (Human))
BDBM239008
PNG
(US9408850, 5)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCc3cccc(Oc4ccccc4)c3)ccc12
Show InChI InChI=1S/C32H31N5O3/c1-36-16-18-37(19-17-36)25-12-10-24(11-13-25)32(38)33-31-29-15-14-27(21-30(29)34-35-31)39-22-23-6-5-9-28(20-23)40-26-7-3-2-4-8-26/h2-15,20-21H,16-19,22H2,1H3,(H2,33,34,35,38)
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n/an/a 2.62E+3n/an/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit


(Homo sapiens (Human))
BDBM239009
PNG
(US9408850, 1)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCc3ccccc3)ccc12
Show InChI InChI=1S/C26H27N5O2/c1-30-13-15-31(16-14-30)21-9-7-20(8-10-21)26(32)27-25-23-12-11-22(17-24(23)28-29-25)33-18-19-5-3-2-4-6-19/h2-12,17H,13-16,18H2,1H3,(H2,27,28,29,32)
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n/an/a 2.81E+3n/an/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...


Citation and Details
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))
BDBM239044
PNG
(US9408850, Ref. Compound)
Show SMILES CN(C)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCc3ccccc3)ccc12
Show InChI InChI=1S/C23H22N4O2/c1-27(2)18-10-8-17(9-11-18)23(28)24-22-20-13-12-19(14-21(20)25-26-22)29-15-16-6-4-3-5-7-16/h3-14H,15H2,1-2H3,(H2,24,25,26,28)
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n/an/a 3.18E+3n/an/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was pre activat...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit


(Homo sapiens (Human))
BDBM239011
PNG
(US9408850, 6)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OC3CCN(Cc4ccccc4)CC3)ccc12
Show InChI InChI=1S/C31H36N6O2/c1-35-17-19-37(20-18-35)25-9-7-24(8-10-25)31(38)32-30-28-12-11-27(21-29(28)33-34-30)39-26-13-15-36(16-14-26)22-23-5-3-2-4-6-23/h2-12,21,26H,13-20,22H2,1H3,(H2,32,33,34,38)
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n/an/a 6.89E+3n/an/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit


(Homo sapiens (Human))
BDBM239015
PNG
(US9408850, 4)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(Oc3ccc(OCc4ccccc4)cc3)ccc12
Show InChI InChI=1S/C32H31N5O3/c1-36-17-19-37(20-18-36)25-9-7-24(8-10-25)32(38)33-31-29-16-15-28(21-30(29)34-35-31)40-27-13-11-26(12-14-27)39-22-23-5-3-2-4-6-23/h2-16,21H,17-20,22H2,1H3,(H2,33,34,35,38)
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n/an/a>1.00E+4n/an/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit


(Homo sapiens (Human))
BDBM239044
PNG
(US9408850, Ref. Compound)
Show SMILES CN(C)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCc3ccccc3)ccc12
Show InChI InChI=1S/C23H22N4O2/c1-27(2)18-10-8-17(9-11-18)23(28)24-22-20-13-12-19(14-21(20)25-26-22)29-15-16-6-4-3-5-7-16/h3-14H,15H2,1-2H3,(H2,24,25,26,28)
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n/an/a>1.00E+4n/an/an/an/an/an/a



NERVIANO MEDICAL SCIENCES S.R.L.

US Patent


Assay Description
The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%