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Patent code US9409868

Compile Data Set for Download or QSAR
Found 44 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Rho-associated protein kinase 2 (ROCK2)


(Homo sapiens (Human))
BDBM50382684
PNG
(CHEMBL2023158 | US9409868, 24)
Show SMILES OC[C@@H](NC(=O)Nc1ccc(cc1)-c1ccncc1)c1ccccc1
Show InChI InChI=1S/C20H19N3O2/c24-14-19(17-4-2-1-3-5-17)23-20(25)22-18-8-6-15(7-9-18)16-10-12-21-13-11-16/h1-13,19,24H,14H2,(H2,22,23,25)/t19-/m1/s1
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n/an/a 100n/an/an/an/an/an/a



H. Lee Moffin Cancer Center and Research Institute, Inc.

US Patent


Assay Description
A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2 (ROCK2)


(Homo sapiens (Human))
BDBM50382685
PNG
(CHEMBL2023156 | US9409868, 22)
Show SMILES O=C(NCc1ccccc1)Nc1ccc(cc1)-c1ccncc1
Show InChI InChI=1S/C19H17N3O/c23-19(21-14-15-4-2-1-3-5-15)22-18-8-6-16(7-9-18)17-10-12-20-13-11-17/h1-13H,14H2,(H2,21,22,23)
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n/an/a 260n/an/an/an/an/an/a



H. Lee Moffin Cancer Center and Research Institute, Inc.

US Patent


Assay Description
A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1 (ROCK1)


(Homo sapiens (Human))
BDBM50382686
PNG
(CHEMBL2023154 | US9409868, 18)
Show SMILES O=C(NCCc1ccccc1)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C16H16N4O/c21-16(17-9-8-12-4-2-1-3-5-12)19-14-6-7-15-13(10-14)11-18-20-15/h1-7,10-11H,8-9H2,(H,18,20)(H2,17,19,21)
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H. Lee Moffin Cancer Center and Research Institute, Inc.

US Patent


Assay Description
A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2 (ROCK2)


(Homo sapiens (Human))
BDBM50382686
PNG
(CHEMBL2023154 | US9409868, 18)
Show SMILES O=C(NCCc1ccccc1)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C16H16N4O/c21-16(17-9-8-12-4-2-1-3-5-12)19-14-6-7-15-13(10-14)11-18-20-15/h1-7,10-11H,8-9H2,(H,18,20)(H2,17,19,21)
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n/an/a 670n/an/an/an/an/an/a



H. Lee Moffin Cancer Center and Research Institute, Inc.

US Patent


Assay Description
A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2 (ROCK2)


(Homo sapiens (Human))
BDBM50382687
PNG
(CHEMBL2023152 | US9409868, 16)
Show SMILES COc1ccc(CCNC(=O)Nc2ccc3[nH]ncc3c2)cc1
Show InChI InChI=1S/C17H18N4O2/c1-23-15-5-2-12(3-6-15)8-9-18-17(22)20-14-4-7-16-13(10-14)11-19-21-16/h2-7,10-11H,8-9H2,1H3,(H,19,21)(H2,18,20,22)
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n/an/a 800n/an/an/an/an/an/a



H. Lee Moffin Cancer Center and Research Institute, Inc.

US Patent


Assay Description
A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2 (ROCK2)


(Homo sapiens (Human))
BDBM50382688
PNG
(CHEMBL2023155 | US9409868, 19)
Show SMILES O=C(NCCCc1ccccc1)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C17H18N4O/c22-17(18-10-4-7-13-5-2-1-3-6-13)20-15-8-9-16-14(11-15)12-19-21-16/h1-3,5-6,8-9,11-12H,4,7,10H2,(H,19,21)(H2,18,20,22)
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n/an/a 1.07E+3n/an/an/an/an/an/a



H. Lee Moffin Cancer Center and Research Institute, Inc.

US Patent


Assay Description
A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2 (ROCK2)


(Homo sapiens (Human))
BDBM50382689
PNG
(CHEMBL2023153 | US9409868, 17)
Show SMILES Clc1ccc(CCNC(=O)Nc2ccc3[nH]ncc3c2)cc1
Show InChI InChI=1S/C16H15ClN4O/c17-13-3-1-11(2-4-13)7-8-18-16(22)20-14-5-6-15-12(9-14)10-19-21-15/h1-6,9-10H,7-8H2,(H,19,21)(H2,18,20,22)
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n/an/a 1.10E+3n/an/an/an/an/an/a



H. Lee Moffin Cancer Center and Research Institute, Inc.

US Patent


Assay Description
A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1 (ROCK1)


(Homo sapiens (Human))
BDBM50382685
PNG
(CHEMBL2023156 | US9409868, 22)
Show SMILES O=C(NCc1ccccc1)Nc1ccc(cc1)-c1ccncc1
Show InChI InChI=1S/C19H17N3O/c23-19(21-14-15-4-2-1-3-5-15)22-18-8-6-16(7-9-18)17-10-12-20-13-11-17/h1-13H,14H2,(H2,21,22,23)
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n/an/a 1.15E+3n/an/an/an/an/an/a



H. Lee Moffin Cancer Center and Research Institute, Inc.

US Patent


Assay Description
A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1 (ROCK1)


(Homo sapiens (Human))
BDBM50382690
PNG
(CHEMBL2023160 | US9409868, 26)
Show SMILES OC[C@@H](Cc1ccccc1)NC(=O)Nc1ccc(cc1)-c1ccncc1
Show InChI InChI=1S/C21H21N3O2/c25-15-20(14-16-4-2-1-3-5-16)24-21(26)23-19-8-6-17(7-9-19)18-10-12-22-13-11-18/h1-13,20,25H,14-15H2,(H2,23,24,26)/t20-/m1/s1
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n/an/a 1.41E+3n/an/an/an/an/an/a



H. Lee Moffin Cancer Center and Research Institute, Inc.

US Patent


Assay Description
A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2 (ROCK2)


(Homo sapiens (Human))
BDBM50382691
PNG
(CHEMBL2023151 | US9409868, 15)
Show SMILES OC(CNC(=O)Nc1ccc2[nH]ncc2c1)c1ccccc1
Show InChI InChI=1S/C16H16N4O2/c21-15(11-4-2-1-3-5-11)10-17-16(22)19-13-6-7-14-12(8-13)9-18-20-14/h1-9,15,21H,10H2,(H,18,20)(H2,17,19,22)
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n/an/a 1.50E+3n/an/an/an/an/an/a



H. Lee Moffin Cancer Center and Research Institute, Inc.

US Patent


Assay Description
A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1 (ROCK1)


(Homo sapiens (Human))
BDBM50382684
PNG
(CHEMBL2023158 | US9409868, 24)
Show SMILES OC[C@@H](NC(=O)Nc1ccc(cc1)-c1ccncc1)c1ccccc1
Show InChI InChI=1S/C20H19N3O2/c24-14-19(17-4-2-1-3-5-17)23-20(25)22-18-8-6-15(7-9-18)16-10-12-21-13-11-16/h1-13,19,24H,14H2,(H2,22,23,25)/t19-/m1/s1
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n/an/a 1.69E+3n/an/an/an/an/an/a



H. Lee Moffin Cancer Center and Research Institute, Inc.

US Patent


Assay Description
A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1 (ROCK1)


(Homo sapiens (Human))
BDBM50382689
PNG
(CHEMBL2023153 | US9409868, 17)
Show SMILES Clc1ccc(CCNC(=O)Nc2ccc3[nH]ncc3c2)cc1
Show InChI InChI=1S/C16H15ClN4O/c17-13-3-1-11(2-4-13)7-8-18-16(22)20-14-5-6-15-12(9-14)10-19-21-15/h1-6,9-10H,7-8H2,(H,19,21)(H2,18,20,22)
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n/an/a 2.20E+3n/an/an/an/an/an/a



H. Lee Moffin Cancer Center and Research Institute, Inc.

US Patent


Assay Description
A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2 (ROCK2)


(Homo sapiens (Human))
BDBM60988
PNG
(US9409868, 14)
Show SMILES OC[C@@H](Cc1ccccc1)NC(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C17H18N4O2/c22-11-15(8-12-4-2-1-3-5-12)20-17(23)19-14-6-7-16-13(9-14)10-18-21-16/h1-7,9-10,15,22H,8,11H2,(H,18,21)(H2,19,20,23)/t15-/m1/s1
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n/an/a 2.30E+3n/an/an/an/an/an/a



H. Lee Moffin Cancer Center and Research Institute, Inc.

US Patent


Assay Description
A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1 (ROCK1)


(Homo sapiens (Human))
BDBM50382688
PNG
(CHEMBL2023155 | US9409868, 19)
Show SMILES O=C(NCCCc1ccccc1)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C17H18N4O/c22-17(18-10-4-7-13-5-2-1-3-6-13)20-15-8-9-16-14(11-15)12-19-21-16/h1-3,5-6,8-9,11-12H,4,7,10H2,(H,19,21)(H2,18,20,22)
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n/an/a 2.46E+3n/an/an/an/an/an/a



H. Lee Moffin Cancer Center and Research Institute, Inc.

US Patent


Assay Description
A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1 (ROCK1)


(Homo sapiens (Human))
BDBM50382687
PNG
(CHEMBL2023152 | US9409868, 16)
Show SMILES COc1ccc(CCNC(=O)Nc2ccc3[nH]ncc3c2)cc1
Show InChI InChI=1S/C17H18N4O2/c1-23-15-5-2-12(3-6-15)8-9-18-17(22)20-14-4-7-16-13(10-14)11-19-21-16/h2-7,10-11H,8-9H2,1H3,(H,19,21)(H2,18,20,22)
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n/an/a 2.60E+3n/an/an/an/an/an/a



H. Lee Moffin Cancer Center and Research Institute, Inc.

US Patent


Assay Description
A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1 (ROCK1)


(Homo sapiens (Human))
BDBM50382693
PNG
(CHEMBL2023159 | US9409868, 25)
Show SMILES O=C(NCCc1ccccc1)Nc1ccc(cc1)-c1ccncc1
Show InChI InChI=1S/C20H19N3O/c24-20(22-15-10-16-4-2-1-3-5-16)23-19-8-6-17(7-9-19)18-11-13-21-14-12-18/h1-9,11-14H,10,15H2,(H2,22,23,24)
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n/an/a 2.61E+3n/an/an/an/an/an/a



H. Lee Moffin Cancer Center and Research Institute, Inc.

US Patent


Assay Description
A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1 (ROCK1)


(Homo sapiens (Human))
BDBM50382691
PNG
(CHEMBL2023151 | US9409868, 15)
Show SMILES OC(CNC(=O)Nc1ccc2[nH]ncc2c1)c1ccccc1
Show InChI InChI=1S/C16H16N4O2/c21-15(11-4-2-1-3-5-11)10-17-16(22)19-13-6-7-14-12(8-13)9-18-20-14/h1-9,15,21H,10H2,(H,18,20)(H2,17,19,22)
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n/an/a 2.90E+3n/an/an/an/an/an/a



H. Lee Moffin Cancer Center and Research Institute, Inc.

US Patent


Assay Description
A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1 (ROCK1)


(Homo sapiens (Human))
BDBM60988
PNG
(US9409868, 14)
Show SMILES OC[C@@H](Cc1ccccc1)NC(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C17H18N4O2/c22-11-15(8-12-4-2-1-3-5-12)20-17(23)19-14-6-7-16-13(9-14)10-18-21-16/h1-7,9-10,15,22H,8,11H2,(H,18,21)(H2,19,20,23)/t15-/m1/s1
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n/an/a 4.60E+3n/an/an/an/an/an/a



H. Lee Moffin Cancer Center and Research Institute, Inc.

US Patent


Assay Description
A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2 (ROCK2)


(Homo sapiens (Human))
BDBM50382690
PNG
(CHEMBL2023160 | US9409868, 26)
Show SMILES OC[C@@H](Cc1ccccc1)NC(=O)Nc1ccc(cc1)-c1ccncc1
Show InChI InChI=1S/C21H21N3O2/c25-15-20(14-16-4-2-1-3-5-16)24-21(26)23-19-8-6-17(7-9-19)18-10-12-22-13-11-18/h1-13,20,25H,14-15H2,(H2,23,24,26)/t20-/m1/s1
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n/an/a 5.36E+3n/an/an/an/an/an/a



H. Lee Moffin Cancer Center and Research Institute, Inc.

US Patent


Assay Description
A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2 (ROCK2)


(Homo sapiens (Human))
BDBM50196697
PNG
(1-benzyl-3-(1H-indazol-5-yl)urea | CHEMBL225282 | ...)
Show SMILES O=C(NCc1ccccc1)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C15H14N4O/c20-15(16-9-11-4-2-1-3-5-11)18-13-6-7-14-12(8-13)10-17-19-14/h1-8,10H,9H2,(H,17,19)(H2,16,18,20)
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n/an/a 5.50E+3n/an/an/an/an/an/a



H. Lee Moffin Cancer Center and Research Institute, Inc.

US Patent


Assay Description
A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2 (ROCK2)


(Homo sapiens (Human))
BDBM50382694
PNG
(CHEMBL2023149 | US9409868, 13)
Show SMILES CN(CCc1ccccc1)C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C17H18N4O/c1-21(10-9-13-5-3-2-4-6-13)17(22)19-15-7-8-16-14(11-15)12-18-20-16/h2-8,11-12H,9-10H2,1H3,(H,18,20)(H,19,22)
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n/an/a 7.50E+3n/an/an/an/an/an/a



H. Lee Moffin Cancer Center and Research Institute, Inc.

US Patent


Assay Description
A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2 (ROCK2)


(Homo sapiens (Human))
BDBM50382695
PNG
(CHEMBL2023157 | US9409868, 23)
Show SMILES OC[C@H](NC(=O)Nc1ccc(cc1)-c1ccncc1)c1ccccc1
Show InChI InChI=1S/C20H19N3O2/c24-14-19(17-4-2-1-3-5-17)23-20(25)22-18-8-6-15(7-9-18)16-10-12-21-13-11-16/h1-13,19,24H,14H2,(H2,22,23,25)/t19-/m0/s1
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n/an/a 7.52E+3n/an/an/an/an/an/a



H. Lee Moffin Cancer Center and Research Institute, Inc.

US Patent


Assay Description
A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1 (ROCK1)


(Homo sapiens (Human))
BDBM50382695
PNG
(CHEMBL2023157 | US9409868, 23)
Show SMILES OC[C@H](NC(=O)Nc1ccc(cc1)-c1ccncc1)c1ccccc1
Show InChI InChI=1S/C20H19N3O2/c24-14-19(17-4-2-1-3-5-17)23-20(25)22-18-8-6-15(7-9-18)16-10-12-21-13-11-16/h1-13,19,24H,14H2,(H2,22,23,25)/t19-/m0/s1
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n/an/a 9.07E+3n/an/an/an/an/an/a



H. Lee Moffin Cancer Center and Research Institute, Inc.

US Patent


Assay Description
A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...


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More data for this
Ligand-Target Pair
Rho-associated protein kinase 1 (ROCK1)


(Homo sapiens (Human))
BDBM50196697
PNG
(1-benzyl-3-(1H-indazol-5-yl)urea | CHEMBL225282 | ...)
Show SMILES O=C(NCc1ccccc1)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C15H14N4O/c20-15(16-9-11-4-2-1-3-5-11)18-13-6-7-14-12(8-13)10-17-19-14/h1-8,10H,9H2,(H,17,19)(H2,16,18,20)
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n/an/a 1.39E+4n/an/an/an/an/an/a



H. Lee Moffin Cancer Center and Research Institute, Inc.

US Patent


Assay Description
A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2 (ROCK2)


(Homo sapiens (Human))
BDBM50382693
PNG
(CHEMBL2023159 | US9409868, 25)
Show SMILES O=C(NCCc1ccccc1)Nc1ccc(cc1)-c1ccncc1
Show InChI InChI=1S/C20H19N3O/c24-20(22-15-10-16-4-2-1-3-5-16)23-19-8-6-17(7-9-19)18-11-13-21-14-12-18/h1-9,11-14H,10,15H2,(H2,22,23,24)
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n/an/a 1.98E+4n/an/an/an/an/an/a



H. Lee Moffin Cancer Center and Research Institute, Inc.

US Patent


Assay Description
A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1 (ROCK1)


(Homo sapiens (Human))
BDBM50382694
PNG
(CHEMBL2023149 | US9409868, 13)
Show SMILES CN(CCc1ccccc1)C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C17H18N4O/c1-21(10-9-13-5-3-2-4-6-13)17(22)19-15-7-8-16-14(11-15)12-18-20-16/h2-8,11-12H,9-10H2,1H3,(H,18,20)(H,19,22)
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n/an/a 2.15E+4n/an/an/an/an/an/a



H. Lee Moffin Cancer Center and Research Institute, Inc.

US Patent


Assay Description
A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1 (ROCK1)


(Homo sapiens (Human))
BDBM50382696
PNG
(CHEMBL2023161 | US9409868, 27)
Show SMILES OC[C@H](Cc1ccccc1)NC(=O)Nc1ccc(cc1)-c1ccncc1
Show InChI InChI=1S/C21H21N3O2/c25-15-20(14-16-4-2-1-3-5-16)24-21(26)23-19-8-6-17(7-9-19)18-10-12-22-13-11-18/h1-13,20,25H,14-15H2,(H2,23,24,26)/t20-/m0/s1
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n/an/a 3.10E+4n/an/an/an/an/an/a



H. Lee Moffin Cancer Center and Research Institute, Inc.

US Patent


Assay Description
A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2 (ROCK2)


(Homo sapiens (Human))
BDBM50382696
PNG
(CHEMBL2023161 | US9409868, 27)
Show SMILES OC[C@H](Cc1ccccc1)NC(=O)Nc1ccc(cc1)-c1ccncc1
Show InChI InChI=1S/C21H21N3O2/c25-15-20(14-16-4-2-1-3-5-16)24-21(26)23-19-8-6-17(7-9-19)18-10-12-22-13-11-18/h1-13,20,25H,14-15H2,(H2,23,24,26)/t20-/m0/s1
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n/an/a 3.29E+4n/an/an/an/an/an/a



H. Lee Moffin Cancer Center and Research Institute, Inc.

US Patent


Assay Description
A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2 (ROCK2)


(Homo sapiens (Human))
BDBM50382697
PNG
(CHEMBL2023147 | US9409868, 10)
Show SMILES CN(C)C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C10H12N4O/c1-14(2)10(15)12-8-3-4-9-7(5-8)6-11-13-9/h3-6H,1-2H3,(H,11,13)(H,12,15)
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n/an/a 3.61E+4n/an/an/an/an/an/a



H. Lee Moffin Cancer Center and Research Institute, Inc.

US Patent


Assay Description
A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2 (ROCK2)


(Homo sapiens (Human))
BDBM50279877
PNG
(CHEMBL67352 | N-Pyridin-4-yl-nicotinamide | US9409...)
Show SMILES O=C(Nc1ccncc1)c1cccnc1
Show InChI InChI=1S/C11H9N3O/c15-11(9-2-1-5-13-8-9)14-10-3-6-12-7-4-10/h1-8H,(H,12,14,15)
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n/an/a 5.59E+4n/an/an/an/an/an/a



H. Lee Moffin Cancer Center and Research Institute, Inc.

US Patent


Assay Description
A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1 (ROCK1)


(Homo sapiens (Human))
BDBM50382697
PNG
(CHEMBL2023147 | US9409868, 10)
Show SMILES CN(C)C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C10H12N4O/c1-14(2)10(15)12-8-3-4-9-7(5-8)6-11-13-9/h3-6H,1-2H3,(H,11,13)(H,12,15)
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n/an/a 5.91E+4n/an/an/an/an/an/a



H. Lee Moffin Cancer Center and Research Institute, Inc.

US Patent


Assay Description
A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2 (ROCK2)


(Homo sapiens (Human))
BDBM50382698
PNG
(CHEMBL2023148 | US9409868, 11)
Show SMILES O=C(Nc1ccccc1)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C14H12N4O/c19-14(16-11-4-2-1-3-5-11)17-12-6-7-13-10(8-12)9-15-18-13/h1-9H,(H,15,18)(H2,16,17,19)
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n/an/a 6.18E+4n/an/an/an/an/an/a



H. Lee Moffin Cancer Center and Research Institute, Inc.

US Patent


Assay Description
A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1 (ROCK1)


(Homo sapiens (Human))
BDBM50382699
PNG
(CHEMBL2022282 | US9409868, 4)
Show SMILES Clc1ccncc1C(=O)Nc1ccncc1
Show InChI InChI=1S/C11H8ClN3O/c12-10-3-6-14-7-9(10)11(16)15-8-1-4-13-5-2-8/h1-7H,(H,13,15,16)
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n/an/a 7.25E+4n/an/an/an/an/an/a



H. Lee Moffin Cancer Center and Research Institute, Inc.

US Patent


Assay Description
A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1 (ROCK1)


(Homo sapiens (Human))
BDBM50279877
PNG
(CHEMBL67352 | N-Pyridin-4-yl-nicotinamide | US9409...)
Show SMILES O=C(Nc1ccncc1)c1cccnc1
Show InChI InChI=1S/C11H9N3O/c15-11(9-2-1-5-13-8-9)14-10-3-6-12-7-4-10/h1-8H,(H,12,14,15)
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n/an/a 7.55E+4n/an/an/an/an/an/a



H. Lee Moffin Cancer Center and Research Institute, Inc.

US Patent


Assay Description
A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2 (ROCK2)


(Homo sapiens (Human))
BDBM50304148
PNG
(1H-Indazol-5-ylamine | 1H-indazol-5-amine | CHEMBL...)
Show SMILES Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C7H7N3/c8-6-1-2-7-5(3-6)4-9-10-7/h1-4H,8H2,(H,9,10)
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n/an/a 1.20E+5n/an/an/an/an/an/a



H. Lee Moffin Cancer Center and Research Institute, Inc.

US Patent


Assay Description
A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1 (ROCK1)


(Homo sapiens (Human))
BDBM50382698
PNG
(CHEMBL2023148 | US9409868, 11)
Show SMILES O=C(Nc1ccccc1)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C14H12N4O/c19-14(16-11-4-2-1-3-5-11)17-12-6-7-13-10(8-12)9-15-18-13/h1-9H,(H,15,18)(H2,16,17,19)
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n/an/a 1.57E+5n/an/an/an/an/an/a



H. Lee Moffin Cancer Center and Research Institute, Inc.

US Patent


Assay Description
A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1 (ROCK1)


(Homo sapiens (Human))
BDBM50304148
PNG
(1H-Indazol-5-ylamine | 1H-indazol-5-amine | CHEMBL...)
Show SMILES Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C7H7N3/c8-6-1-2-7-5(3-6)4-9-10-7/h1-4H,8H2,(H,9,10)
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n/an/a 1.81E+5n/an/an/an/an/an/a



H. Lee Moffin Cancer Center and Research Institute, Inc.

US Patent


Assay Description
A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2 (ROCK2)


(Homo sapiens (Human))
BDBM50382699
PNG
(CHEMBL2022282 | US9409868, 4)
Show SMILES Clc1ccncc1C(=O)Nc1ccncc1
Show InChI InChI=1S/C11H8ClN3O/c12-10-3-6-14-7-9(10)11(16)15-8-1-4-13-5-2-8/h1-7H,(H,13,15,16)
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n/an/a 2.21E+5n/an/an/an/an/an/a



H. Lee Moffin Cancer Center and Research Institute, Inc.

US Patent


Assay Description
A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1 (ROCK1)


(Homo sapiens (Human))
BDBM50382700
PNG
(CHEMBL1566648 | US9409868, 5)
Show SMILES Brc1cncc(c1)C(=O)Nc1ccncc1
Show InChI InChI=1S/C11H8BrN3O/c12-9-5-8(6-14-7-9)11(16)15-10-1-3-13-4-2-10/h1-7H,(H,13,15,16)
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n/an/a 2.70E+5n/an/an/an/an/an/a



H. Lee Moffin Cancer Center and Research Institute, Inc.

US Patent


Assay Description
A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2 (ROCK2)


(Homo sapiens (Human))
BDBM50382700
PNG
(CHEMBL1566648 | US9409868, 5)
Show SMILES Brc1cncc(c1)C(=O)Nc1ccncc1
Show InChI InChI=1S/C11H8BrN3O/c12-9-5-8(6-14-7-9)11(16)15-10-1-3-13-4-2-10/h1-7H,(H,13,15,16)
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n/an/a 3.57E+5n/an/an/an/an/an/a



H. Lee Moffin Cancer Center and Research Institute, Inc.

US Patent


Assay Description
A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1 (ROCK1)


(Homo sapiens (Human))
BDBM50382701
PNG
(CHEMBL2023144 | US9409868, 6)
Show SMILES Fc1ccc(cc1)-c1ccncc1C(=O)Nc1ccncc1
Show InChI InChI=1S/C17H12FN3O/c18-13-3-1-12(2-4-13)15-7-10-20-11-16(15)17(22)21-14-5-8-19-9-6-14/h1-11H,(H,19,21,22)
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n/an/a>4.00E+6n/an/an/an/an/an/a



H. Lee Moffin Cancer Center and Research Institute, Inc.

US Patent


Assay Description
A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1 (ROCK1)


(Homo sapiens (Human))
BDBM50382702
PNG
(CHEMBL2023145 | US9409868, 7)
Show SMILES Fc1ccc(cc1)-c1cncc(c1)C(=O)Nc1ccncc1
Show InChI InChI=1S/C17H12FN3O/c18-15-3-1-12(2-4-15)13-9-14(11-20-10-13)17(22)21-16-5-7-19-8-6-16/h1-11H,(H,19,21,22)
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n/an/a>4.00E+6n/an/an/an/an/an/a



H. Lee Moffin Cancer Center and Research Institute, Inc.

US Patent


Assay Description
A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2 (ROCK2)


(Homo sapiens (Human))
BDBM50382701
PNG
(CHEMBL2023144 | US9409868, 6)
Show SMILES Fc1ccc(cc1)-c1ccncc1C(=O)Nc1ccncc1
Show InChI InChI=1S/C17H12FN3O/c18-13-3-1-12(2-4-13)15-7-10-20-11-16(15)17(22)21-14-5-8-19-9-6-14/h1-11H,(H,19,21,22)
PDB

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n/an/a>4.00E+6n/an/an/an/an/an/a



H. Lee Moffin Cancer Center and Research Institute, Inc.

US Patent


Assay Description
A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...


Citation and Details
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2 (ROCK2)


(Homo sapiens (Human))
BDBM50382702
PNG
(CHEMBL2023145 | US9409868, 7)
Show SMILES Fc1ccc(cc1)-c1cncc(c1)C(=O)Nc1ccncc1
Show InChI InChI=1S/C17H12FN3O/c18-15-3-1-12(2-4-15)13-9-14(11-20-10-13)17(22)21-16-5-7-19-8-6-16/h1-11H,(H,19,21,22)
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n/an/a>4.00E+6n/an/an/an/an/an/a



H. Lee Moffin Cancer Center and Research Institute, Inc.

US Patent


Assay Description
A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%