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Patent code US9409892

Compile Data Set for Download or QSAR

Found 368 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM241059
PNG
(US9409892, 154)
Show SMILES OC(=O)C1(CNC(=O)c2nc(C#N)c3cc(Sc4ccccc4)ccc3c2O)CCC1
Show InChI InChI=1S/C23H19N3O4S/c24-12-18-17-11-15(31-14-5-2-1-3-6-14)7-8-16(17)20(27)19(26-18)21(28)25-13-23(22(29)30)9-4-10-23/h1-3,5-8,11,27H,4,9-10,13H2,(H,25,28)(H,29,30)
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FibroGen, Inc.

US Patent


Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources...


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM240984
PNG
(US9409892, 79)
Show SMILES O[C@@H](CNC(=O)c1nc(C#N)c2cc(Oc3ccccc3)ccc2c1O)C(O)=O
Show InChI InChI=1S/C20H15N3O6/c21-9-15-14-8-12(29-11-4-2-1-3-5-11)6-7-13(14)18(25)17(23-15)19(26)22-10-16(24)20(27)28/h1-8,16,24-25H,10H2,(H,22,26)(H,27,28)/t16-/m0/s1
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FibroGen, Inc.

US Patent


Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources...


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM240964
PNG
(US9409892, 59)
Show SMILES CC(C)(CNC(=O)c1nc(C#N)c2cc(Oc3ccc4ccccc4c3)ccc2c1O)C(O)=O
Show InChI InChI=1S/C26H21N3O5/c1-26(2,25(32)33)14-28-24(31)22-23(30)19-10-9-18(12-20(19)21(13-27)29-22)34-17-8-7-15-5-3-4-6-16(15)11-17/h3-12,30H,14H2,1-2H3,(H,28,31)(H,32,33)
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FibroGen, Inc.

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Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources...


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM240985
PNG
(US9409892, 80)
Show SMILES OC(=O)CCCNC(=O)c1nc(C#N)c2cc(Oc3ccccc3)ccc2c1O
Show InChI InChI=1S/C21H17N3O5/c22-12-17-16-11-14(29-13-5-2-1-3-6-13)8-9-15(16)20(27)19(24-17)21(28)23-10-4-7-18(25)26/h1-3,5-6,8-9,11,27H,4,7,10H2,(H,23,28)(H,25,26)
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Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources...


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM240981
PNG
(US9409892, 76)
Show SMILES OC(CNC(=O)c1nc(C#N)c2cc(Oc3ccccc3)ccc2c1O)C(O)=O
Show InChI InChI=1S/C20H15N3O6/c21-9-15-14-8-12(29-11-4-2-1-3-5-11)6-7-13(14)18(25)17(23-15)19(26)22-10-16(24)20(27)28/h1-8,16,24-25H,10H2,(H,22,26)(H,27,28)
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FibroGen, Inc.

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Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources...


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM240998
PNG
(US9409892, 93)
Show SMILES C[C@@H](CNC(=O)c1nc(C#N)c2cc(Oc3ccccc3)ccc2c1O)C(O)=O
Show InChI InChI=1S/C21H17N3O5/c1-12(21(27)28)11-23-20(26)18-19(25)15-8-7-14(9-16(15)17(10-22)24-18)29-13-5-3-2-4-6-13/h2-9,12,25H,11H2,1H3,(H,23,26)(H,27,28)/t12-/m0/s1
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FibroGen, Inc.

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Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources...


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM240917
PNG
(US9409892, 12)
Show SMILES OC(=O)C1(CNC(=O)c2nc(C#N)c3cc(Oc4ccccc4)ccc3c2O)CC1
Show InChI InChI=1S/C22H17N3O5/c23-11-17-16-10-14(30-13-4-2-1-3-5-13)6-7-15(16)19(26)18(25-17)20(27)24-12-22(8-9-22)21(28)29/h1-7,10,26H,8-9,12H2,(H,24,27)(H,28,29)
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FibroGen, Inc.

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Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources...


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM240944
PNG
(US9409892, 39)
Show SMILES CC(C)(CNC(=O)c1nc(C#N)c2cc(Oc3cccc(Cl)c3)ccc2c1O)C(O)=O
Show InChI InChI=1S/C22H18ClN3O5/c1-22(2,21(29)30)11-25-20(28)18-19(27)15-7-6-14(9-16(15)17(10-24)26-18)31-13-5-3-4-12(23)8-13/h3-9,27H,11H2,1-2H3,(H,25,28)(H,29,30)
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FibroGen, Inc.

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Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources...


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM240948
PNG
(US9409892, 43)
Show SMILES CC(C)(CNC(=O)c1nc(C#N)c2cc(Oc3cccc4ccccc34)ccc2c1O)C(O)=O
Show InChI InChI=1S/C26H21N3O5/c1-26(2,25(32)33)14-28-24(31)22-23(30)18-11-10-16(12-19(18)20(13-27)29-22)34-21-9-5-7-15-6-3-4-8-17(15)21/h3-12,30H,14H2,1-2H3,(H,28,31)(H,32,33)
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FibroGen, Inc.

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Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources...


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM240940
PNG
(US9409892, 35)
Show SMILES O[C@H](CNC(=O)c1nc(C#N)c2cc(Oc3ccccc3)ccc2c1O)CC(O)=O
Show InChI InChI=1S/C21H17N3O6/c22-10-17-16-9-14(30-13-4-2-1-3-5-13)6-7-15(16)20(28)19(24-17)21(29)23-11-12(25)8-18(26)27/h1-7,9,12,25,28H,8,11H2,(H,23,29)(H,26,27)/t12-/m0/s1
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Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources...


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM240926
PNG
(US9409892, 21)
Show SMILES COc1ccc(Oc2ccc3c(O)c(nc(C#N)c3c2)C(=O)NC(C)(C)CC(O)=O)cc1
Show InChI InChI=1S/C23H21N3O6/c1-23(2,11-19(27)28)26-22(30)20-21(29)16-9-8-15(10-17(16)18(12-24)25-20)32-14-6-4-13(31-3)5-7-14/h4-10,29H,11H2,1-3H3,(H,26,30)(H,27,28)
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FibroGen, Inc.

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Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources...


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM240943
PNG
(US9409892, 38)
Show SMILES CC(C)(CNC(=O)c1nc(C#N)c2cc(Oc3ccccc3Cl)ccc2c1O)C(O)=O
Show InChI InChI=1S/C22H18ClN3O5/c1-22(2,21(29)30)11-25-20(28)18-19(27)13-8-7-12(9-14(13)16(10-24)26-18)31-17-6-4-3-5-15(17)23/h3-9,27H,11H2,1-2H3,(H,25,28)(H,29,30)
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Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources...


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM240988
PNG
(US9409892, 83)
Show SMILES O[C@@H](CCNC(=O)c1nc(C#N)c2cc(Oc3ccccc3)ccc2c1O)C(O)=O
Show InChI InChI=1S/C21H17N3O6/c22-11-16-15-10-13(30-12-4-2-1-3-5-12)6-7-14(15)19(26)18(24-16)20(27)23-9-8-17(25)21(28)29/h1-7,10,17,25-26H,8-9H2,(H,23,27)(H,28,29)/t17-/m0/s1
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Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources...


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM240915
PNG
(US9409892, 10)
Show SMILES OC(=O)CCNC(=O)c1nc(C#N)c2cc(Oc3ccccc3)ccc2c1O
Show InChI InChI=1S/C20H15N3O5/c21-11-16-15-10-13(28-12-4-2-1-3-5-12)6-7-14(15)19(26)18(23-16)20(27)22-9-8-17(24)25/h1-7,10,26H,8-9H2,(H,22,27)(H,24,25)
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Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources...


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM240958
PNG
(US9409892, 53)
Show SMILES COC(=O)NC(CCNC(=O)c1nc(C#N)c2cc(Oc3ccccc3)ccc2c1O)C(O)=O
Show InChI InChI=1S/C23H20N4O7/c1-33-23(32)27-17(22(30)31)9-10-25-21(29)19-20(28)15-8-7-14(11-16(15)18(12-24)26-19)34-13-5-3-2-4-6-13/h2-8,11,17,28H,9-10H2,1H3,(H,25,29)(H,27,32)(H,30,31)
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Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources...


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM240961
PNG
(US9409892, 56)
Show SMILES OC(=O)C(=O)CCNC(=O)c1nc(C#N)c2cc(Oc3ccccc3)ccc2c1O
Show InChI InChI=1S/C21H15N3O6/c22-11-16-15-10-13(30-12-4-2-1-3-5-12)6-7-14(15)19(26)18(24-16)20(27)23-9-8-17(25)21(28)29/h1-7,10,26H,8-9H2,(H,23,27)(H,28,29)
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Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources...


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM241003
PNG
(US9409892, 98)
Show SMILES OC(=O)CCCCNC(=O)c1nc(C#N)c2cc(Oc3ccc(F)cc3Cl)ccc2c1O
Show InChI InChI=1S/C22H17ClFN3O5/c23-16-9-12(24)4-7-18(16)32-13-5-6-14-15(10-13)17(11-25)27-20(21(14)30)22(31)26-8-2-1-3-19(28)29/h4-7,9-10,30H,1-3,8H2,(H,26,31)(H,28,29)
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Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources...


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM240956
PNG
(US9409892, 51)
Show SMILES CC(=O)N[C@H](CCNC(=O)c1nc(C#N)c2cc(Oc3ccccc3)ccc2c1O)C(O)=O
Show InChI InChI=1S/C23H20N4O6/c1-13(28)26-18(23(31)32)9-10-25-22(30)20-21(29)16-8-7-15(11-17(16)19(12-24)27-20)33-14-5-3-2-4-6-14/h2-8,11,18,29H,9-10H2,1H3,(H,25,30)(H,26,28)(H,31,32)/t18-/m1/s1
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Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources...


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM240949
PNG
(US9409892, 44)
Show SMILES Cc1ccc(Oc2ccc3c(O)c(nc(C#N)c3c2)C(=O)NCC(C)(C)C(O)=O)cc1
Show InChI InChI=1S/C23H21N3O5/c1-13-4-6-14(7-5-13)31-15-8-9-16-17(10-15)18(11-24)26-19(20(16)27)21(28)25-12-23(2,3)22(29)30/h4-10,27H,12H2,1-3H3,(H,25,28)(H,29,30)
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Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources...


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM240997
PNG
(US9409892, 92)
Show SMILES C[C@H](CNC(=O)c1nc(C#N)c2cc(Oc3ccccc3)ccc2c1O)C(O)=O
Show InChI InChI=1S/C21H17N3O5/c1-12(21(27)28)11-23-20(26)18-19(25)15-8-7-14(9-16(15)17(10-22)24-18)29-13-5-3-2-4-6-13/h2-9,12,25H,11H2,1H3,(H,23,26)(H,27,28)/t12-/m1/s1
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FibroGen, Inc.

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Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources...


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM241004
PNG
(US9409892, 99)
Show SMILES CC(C)(CNC(=O)c1nc(C#N)c2cc(Oc3ccc(F)cc3Cl)ccc2c1O)C(O)=O
Show InChI InChI=1S/C22H17ClFN3O5/c1-22(2,21(30)31)10-26-20(29)18-19(28)13-5-4-12(8-14(13)16(9-25)27-18)32-17-6-3-11(24)7-15(17)23/h3-8,28H,10H2,1-2H3,(H,26,29)(H,30,31)
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FibroGen, Inc.

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Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources...


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM240945
PNG
(US9409892, 40)
Show SMILES CC(C)(CNC(=O)c1nc(C#N)c2cc(Oc3ccc(Cl)cc3)ccc2c1O)C(O)=O
Show InChI InChI=1S/C22H18ClN3O5/c1-22(2,21(29)30)11-25-20(28)18-19(27)15-8-7-14(9-16(15)17(10-24)26-18)31-13-5-3-12(23)4-6-13/h3-9,27H,11H2,1-2H3,(H,25,28)(H,29,30)
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Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources...


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM240999
PNG
(US9409892, 94)
Show SMILES CO[C@@H](CCNC(=O)c1nc(C#N)c2cc(Oc3ccccc3)ccc2c1O)C(O)=O
Show InChI InChI=1S/C22H19N3O6/c1-30-18(22(28)29)9-10-24-21(27)19-20(26)15-8-7-14(11-16(15)17(12-23)25-19)31-13-5-3-2-4-6-13/h2-8,11,18,26H,9-10H2,1H3,(H,24,27)(H,28,29)/t18-/m0/s1
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Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources...


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More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM240919
PNG
(US9409892, 14)
Show SMILES OC(=O)C1(CNC(=O)c2nc(C#N)c3cc(Oc4ccccc4)ccc3c2O)CCC1
Show InChI InChI=1S/C23H19N3O5/c24-12-18-17-11-15(31-14-5-2-1-3-6-14)7-8-16(17)20(27)19(26-18)21(28)25-13-23(22(29)30)9-4-10-23/h1-3,5-8,11,27H,4,9-10,13H2,(H,25,28)(H,29,30)
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Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources...


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More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM240989
PNG
(US9409892, 84)
Show SMILES CC(C)(CCNC(=O)c1nc(C#N)c2cc(Oc3ccccc3)ccc2c1O)C(O)=O
Show InChI InChI=1S/C23H21N3O5/c1-23(2,22(29)30)10-11-25-21(28)19-20(27)16-9-8-15(12-17(16)18(13-24)26-19)31-14-6-4-3-5-7-14/h3-9,12,27H,10-11H2,1-2H3,(H,25,28)(H,29,30)
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Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources...


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More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM241040
PNG
(US9409892, 135)
Show SMILES OC(=O)CCNC(=O)c1ncc2cc(ccc2c1O)S(=O)(=O)C1CCCCC1
Show InChI InChI=1S/C19H22N2O6S/c22-16(23)8-9-20-19(25)17-18(24)15-7-6-14(10-12(15)11-21-17)28(26,27)13-4-2-1-3-5-13/h6-7,10-11,13,24H,1-5,8-9H2,(H,20,25)(H,22,23)
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Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources...


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More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM240925
PNG
(US9409892, 20)
Show SMILES COc1ccc(Oc2ccc3c(O)c(nc(C#N)c3c2)C(=O)NCC(C)(C)C(O)=O)cc1
Show InChI InChI=1S/C23H21N3O6/c1-23(2,22(29)30)12-25-21(28)19-20(27)16-9-8-15(10-17(16)18(11-24)26-19)32-14-6-4-13(31-3)5-7-14/h4-10,27H,12H2,1-3H3,(H,25,28)(H,29,30)
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Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources...


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More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM240947
PNG
(US9409892, 42)
Show SMILES CC(C)(CNC(=O)c1nc(C#N)c2cc(Oc3cccc(F)c3)ccc2c1O)C(O)=O
Show InChI InChI=1S/C22H18FN3O5/c1-22(2,21(29)30)11-25-20(28)18-19(27)15-7-6-14(9-16(15)17(10-24)26-18)31-13-5-3-4-12(23)8-13/h3-9,27H,11H2,1-2H3,(H,25,28)(H,29,30)
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Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources...


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More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM241006
PNG
(US9409892, 101)
Show SMILES CC(C)(CNC(=O)c1nc(C#N)c2cc(Oc3ccc(F)cc3)ccc2c1O)C(O)=O
Show InChI InChI=1S/C22H18FN3O5/c1-22(2,21(29)30)11-25-20(28)18-19(27)15-8-7-14(9-16(15)17(10-24)26-18)31-13-5-3-12(23)4-6-13/h3-9,27H,11H2,1-2H3,(H,25,28)(H,29,30)
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Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources...


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM240982
PNG
(US9409892, 77)
Show SMILES CC(C)(CNC(=O)c1nc(C#N)c2cc(Oc3ccccc3)ccc2c1O)C(O)=O
Show InChI InChI=1S/C22H19N3O5/c1-22(2,21(28)29)12-24-20(27)18-19(26)15-9-8-14(10-16(15)17(11-23)25-18)30-13-6-4-3-5-7-13/h3-10,26H,12H2,1-2H3,(H,24,27)(H,28,29)
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Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources...


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM240986
PNG
(US9409892, 81)
Show SMILES OC(=O)CCCCNC(=O)c1nc(C#N)c2cc(Oc3ccccc3)ccc2c1O
Show InChI InChI=1S/C22H19N3O5/c23-13-18-17-12-15(30-14-6-2-1-3-7-14)9-10-16(17)21(28)20(25-18)22(29)24-11-5-4-8-19(26)27/h1-3,6-7,9-10,12,28H,4-5,8,11H2,(H,24,29)(H,26,27)
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Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources...


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM241071
PNG
(US9409892, 166)
Show SMILES OC(=O)C(CNC(=O)c1nc(C#N)c2cc(Oc3ccccc3)ccc2c1O)C1CC1
Show InChI InChI=1S/C23H19N3O5/c24-11-19-17-10-15(31-14-4-2-1-3-5-14)8-9-16(17)21(27)20(26-19)22(28)25-12-18(23(29)30)13-6-7-13/h1-5,8-10,13,18,27H,6-7,12H2,(H,25,28)(H,29,30)
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Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources...


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM240967
PNG
(US9409892, 62)
Show SMILES CCc1ccccc1Oc1ccc2c(O)c(nc(C#N)c2c1)C(=O)NCC(C)(C)C(O)=O
Show InChI InChI=1S/C24H23N3O5/c1-4-14-7-5-6-8-19(14)32-15-9-10-16-17(11-15)18(12-25)27-20(21(16)28)22(29)26-13-24(2,3)23(30)31/h5-11,28H,4,13H2,1-3H3,(H,26,29)(H,30,31)
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Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources...


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM240936
PNG
(US9409892, 31)
Show SMILES CC(C)(CNC(=O)c1nc(C#N)c2cc(Oc3cc(F)ccc3Cl)ccc2c1O)C(O)=O
Show InChI InChI=1S/C22H17ClFN3O5/c1-22(2,21(30)31)10-26-20(29)18-19(28)13-5-4-12(8-14(13)16(9-25)27-18)32-17-7-11(24)3-6-15(17)23/h3-8,28H,10H2,1-2H3,(H,26,29)(H,30,31)
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Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources...


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM241007
PNG
(US9409892, 102)
Show SMILES CC(C)(CC(O)=O)NC(=O)c1nc(C#N)c2cc(Oc3ccc(F)cc3)ccc2c1O
Show InChI InChI=1S/C22H18FN3O5/c1-22(2,10-18(27)28)26-21(30)19-20(29)15-8-7-14(9-16(15)17(11-24)25-19)31-13-5-3-12(23)4-6-13/h3-9,29H,10H2,1-2H3,(H,26,30)(H,27,28)
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Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources...


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM240962
PNG
(US9409892, 57)
Show SMILES CCC(CNC(=O)c1nc(C#N)c2cc(Oc3ccccc3)ccc2c1O)C(O)=O
Show InChI InChI=1S/C22H19N3O5/c1-2-13(22(28)29)12-24-21(27)19-20(26)16-9-8-15(10-17(16)18(11-23)25-19)30-14-6-4-3-5-7-14/h3-10,13,26H,2,12H2,1H3,(H,24,27)(H,28,29)
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Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources...


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM240946
PNG
(US9409892, 41)
Show SMILES CC(C)(CNC(=O)c1nc(C#N)c2cc(Oc3ccccc3F)ccc2c1O)C(O)=O
Show InChI InChI=1S/C22H18FN3O5/c1-22(2,21(29)30)11-25-20(28)18-19(27)13-8-7-12(9-14(13)16(10-24)26-18)31-17-6-4-3-5-15(17)23/h3-9,27H,11H2,1-2H3,(H,25,28)(H,29,30)
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Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources...


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM241042
PNG
(US9409892, 137)
Show SMILES OC(=O)CCNC(=O)c1nc(C#N)c2cc(ccc2c1O)-c1ccccc1
Show InChI InChI=1S/C20H15N3O4/c21-11-16-15-10-13(12-4-2-1-3-5-12)6-7-14(15)19(26)18(23-16)20(27)22-9-8-17(24)25/h1-7,10,26H,8-9H2,(H,22,27)(H,24,25)
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Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources...


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM240931
PNG
(US9409892, 26)
Show SMILES OC(=O)C1(CNC(=O)c2nc(C#N)c3cc(Oc4c(F)cccc4F)ccc3c2O)CCC1
Show InChI InChI=1S/C23H17F2N3O5/c24-15-3-1-4-16(25)20(15)33-12-5-6-13-14(9-12)17(10-26)28-18(19(13)29)21(30)27-11-23(22(31)32)7-2-8-23/h1,3-6,9,29H,2,7-8,11H2,(H,27,30)(H,31,32)
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Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM240985
PNG
(US9409892, 80)
Show SMILES OC(=O)CCCNC(=O)c1nc(C#N)c2cc(Oc3ccccc3)ccc2c1O
Show InChI InChI=1S/C21H17N3O5/c22-12-17-16-11-14(29-13-5-2-1-3-6-13)8-9-15(16)20(27)19(24-17)21(28)23-10-4-7-18(25)26/h1-3,5-6,8-9,11,27H,4,7,10H2,(H,23,28)(H,25,26)
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US Patent


Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources...


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM240970
PNG
(US9409892, 65)
Show SMILES OC(=O)C(F)(F)CNC(=O)c1nc(C#N)c2cc(Oc3ccccc3)ccc2c1O
Show InChI InChI=1S/C20H13F2N3O5/c21-20(22,19(28)29)10-24-18(27)16-17(26)13-7-6-12(8-14(13)15(9-23)25-16)30-11-4-2-1-3-5-11/h1-8,26H,10H2,(H,24,27)(H,28,29)
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Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources...


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM240978
PNG
(US9409892, 73)
Show SMILES C[C@](O)(CNC(=O)c1nc(C#N)c2cc(Oc3ccccc3)ccc2c1O)C(O)=O
Show InChI InChI=1S/C21H17N3O6/c1-21(29,20(27)28)11-23-19(26)17-18(25)14-8-7-13(9-15(14)16(10-22)24-17)30-12-5-3-2-4-6-12/h2-9,25,29H,11H2,1H3,(H,23,26)(H,27,28)/t21-/m0/s1
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Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources...


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM241000
PNG
(US9409892, 95)
Show SMILES CC(C)(CCCNC(=O)c1nc(C#N)c2cc(Oc3ccccc3)ccc2c1O)C(O)=O
Show InChI InChI=1S/C24H23N3O5/c1-24(2,23(30)31)11-6-12-26-22(29)20-21(28)17-10-9-16(13-18(17)19(14-25)27-20)32-15-7-4-3-5-8-15/h3-5,7-10,13,28H,6,11-12H2,1-2H3,(H,26,29)(H,30,31)
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n/an/a 740n/an/an/an/an/an/a



FibroGen, Inc.

US Patent


Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources...


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM241082
PNG
(US9409892, 177)
Show SMILES OC(=O)C(CNC(=O)c1nc(C#N)c2cc(Oc3ccccc3F)ccc2c1O)C1CC1
Show InChI InChI=1S/C23H18FN3O5/c24-17-3-1-2-4-19(17)32-13-7-8-14-15(9-13)18(10-25)27-20(21(14)28)22(29)26-11-16(23(30)31)12-5-6-12/h1-4,7-9,12,16,28H,5-6,11H2,(H,26,29)(H,30,31)
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n/an/a 750n/an/an/an/an/an/a



FibroGen, Inc.

US Patent


Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources...


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM241008
PNG
(US9409892, 103)
Show SMILES COc1ccc(Oc2ccc3c(O)c(ncc3c2)C(=O)NC[C@H](O)C(O)=O)cc1
Show InChI InChI=1S/C20H18N2O7/c1-28-12-2-4-13(5-3-12)29-14-6-7-15-11(8-14)9-21-17(18(15)24)19(25)22-10-16(23)20(26)27/h2-9,16,23-24H,10H2,1H3,(H,22,25)(H,26,27)/t16-/m0/s1
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n/an/a 790n/an/an/an/an/an/a



FibroGen, Inc.

US Patent


Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources...


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM241026
PNG
(US9409892, 121)
Show SMILES CC(C)(CNC(=O)c1nc(C#N)c2cc(Sc3ccccc3)ccc2c1O)C(O)=O
Show InChI InChI=1S/C22H19N3O4S/c1-22(2,21(28)29)12-24-20(27)18-19(26)15-9-8-14(10-16(15)17(11-23)25-18)30-13-6-4-3-5-7-13/h3-10,26H,12H2,1-2H3,(H,24,27)(H,28,29)
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FibroGen, Inc.

US Patent


Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources...


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM241038
PNG
(US9409892, 133)
Show SMILES OC(=O)CCNC(=O)c1ncc2cc(NC(=O)NCc3ccccc3)ccc2c1O
Show InChI InChI=1S/C21H20N4O5/c26-17(27)8-9-22-20(29)18-19(28)16-7-6-15(10-14(16)12-23-18)25-21(30)24-11-13-4-2-1-3-5-13/h1-7,10,12,28H,8-9,11H2,(H,22,29)(H,26,27)(H2,24,25,30)
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n/an/a 850n/an/an/an/an/an/a



FibroGen, Inc.

US Patent


Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM240964
PNG
(US9409892, 59)
Show SMILES CC(C)(CNC(=O)c1nc(C#N)c2cc(Oc3ccc4ccccc4c3)ccc2c1O)C(O)=O
Show InChI InChI=1S/C26H21N3O5/c1-26(2,25(32)33)14-28-24(31)22-23(30)19-10-9-18(12-20(19)21(13-27)29-22)34-17-8-7-15-5-3-4-6-16(15)11-17/h3-12,30H,14H2,1-2H3,(H,28,31)(H,32,33)
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n/an/a 860n/an/an/an/an/an/a



FibroGen, Inc.

US Patent


Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources...


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM241064
PNG
(US9409892, 159)
Show SMILES OC(=O)C1(CNC(=O)c2nc(C#N)c3cc(OC4CCCCC4)ccc3c2O)CCC1
Show InChI InChI=1S/C23H25N3O5/c24-12-18-17-11-15(31-14-5-2-1-3-6-14)7-8-16(17)20(27)19(26-18)21(28)25-13-23(22(29)30)9-4-10-23/h7-8,11,14,27H,1-6,9-10,13H2,(H,25,28)(H,29,30)
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n/an/a 910n/an/an/an/an/an/a



FibroGen, Inc.

US Patent


Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources...


Citation and Details
More data for this
Ligand-Target Pair
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM240987
PNG
(US9409892, 82)
Show SMILES CC(C)(CC(O)=O)NC(=O)c1nc(C#N)c2cc(Oc3ccccc3)ccc2c1O
Show InChI InChI=1S/C22H19N3O5/c1-22(2,11-18(26)27)25-21(29)19-20(28)15-9-8-14(10-16(15)17(12-23)24-19)30-13-6-4-3-5-7-13/h3-10,28H,11H2,1-2H3,(H,25,29)(H,26,27)
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n/an/a 910n/an/an/an/an/an/a



FibroGen, Inc.

US Patent


Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide may be obtained from commercial sources...


Citation and Details
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%