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Patent code US9409915

Compile Data Set for Download or QSAR
Found 90 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241685
PNG
(US9409915, 89 | US9718820, Compound 89)
Show SMILES Cn1nc(c(Cl)c1-c1nc2cc(nc(OCC(F)(F)F)c2[nH]1)-c1ccccc1Cl)C(C)(C)C
Show InChI InChI=1S/C22H20Cl2F3N5O/c1-21(2,3)18-15(24)17(32(4)31-18)19-28-14-9-13(11-7-5-6-8-12(11)23)29-20(16(14)30-19)33-10-22(25,26)27/h5-9H,10H2,1-4H3,(H,28,30)
KEGG

UniProtKB/TrEMBL

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US Patent
n/an/a 0.530n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241633
PNG
(US9409915, 16 | US9718820, Compound 16)
Show SMILES CC(C)Oc1nc(cc2nc([nH]c12)-c1c(Cl)c(nn1C)C(C)(C)C)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C24H25ClF3N5O/c1-12(2)34-22-18-16(11-15(30-22)13-9-7-8-10-14(13)24(26,27)28)29-21(31-18)19-17(25)20(23(3,4)5)32-33(19)6/h7-12H,1-6H3,(H,29,31)
KEGG

UniProtKB/TrEMBL

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US Patent
n/an/a 0.590n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241638
PNG
(US9409915, 21 | US9718820, Compound 21)
Show SMILES COCCOc1nc(cc2nc([nH]c12)-c1c(C#N)c(nn1C)C(C)(C)C)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C25H25F3N6O2/c1-24(2,3)21-15(13-29)20(34(4)33-21)22-30-18-12-17(14-8-6-7-9-16(14)25(26,27)28)31-23(19(18)32-22)36-11-10-35-5/h6-9,12H,10-11H2,1-5H3,(H,30,32)
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US Patent
n/an/a 0.690n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241686
PNG
(US9409915, 90 | US9718820, Compound 90)
Show SMILES Cn1nc(c(Cl)c1-c1nc2cc(nc(OCC(F)(F)F)c2[nH]1)-c1ccccc1OC(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C23H20ClF6N5O2/c1-21(2,3)18-15(24)17(35(4)34-18)19-31-13-9-12(11-7-5-6-8-14(11)37-23(28,29)30)32-20(16(13)33-19)36-10-22(25,26)27/h5-9H,10H2,1-4H3,(H,31,33)
KEGG

UniProtKB/TrEMBL

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US Patent
n/an/a 0.730n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241636
PNG
(US9409915, 19 | US9718820, Compound 19)
Show SMILES Cn1nc(c(Cl)c1-c1nc2cc(nc(OCC(F)(F)F)c2[nH]1)-c1ccccc1C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C23H20ClF6N5O/c1-21(2,3)18-15(24)17(35(4)34-18)19-31-14-9-13(11-7-5-6-8-12(11)23(28,29)30)32-20(16(14)33-19)36-10-22(25,26)27/h5-9H,10H2,1-4H3,(H,31,33)
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UniProtKB/TrEMBL

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US Patent
n/an/a 0.840n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241637
PNG
(US9409915, 20 | US9718820, Compound 20)
Show SMILES COCCOc1nc(cc2nc([nH]c12)-c1c(Cl)c(nn1C)C(C)(C)C)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C24H25ClF3N5O2/c1-23(2,3)20-17(25)19(33(4)32-20)21-29-16-12-15(13-8-6-7-9-14(13)24(26,27)28)30-22(18(16)31-21)35-11-10-34-5/h6-9,12H,10-11H2,1-5H3,(H,29,31)
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n/an/a 0.950n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241620
PNG
(US9409915, 59 | US9718820, Compound 59A)
Show SMILES Cn1nc(c(Cl)c1-c1nc2cc(nc(N3CCOCC3)c2[nH]1)-c1ccccc1C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C25H26ClF3N6O/c1-24(2,3)21-18(26)20(34(4)33-21)22-30-17-13-16(14-7-5-6-8-15(14)25(27,28)29)31-23(19(17)32-22)35-9-11-36-12-10-35/h5-8,13H,9-12H2,1-4H3,(H,30,32)
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US Patent
n/an/a 1.10n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241631
PNG
(US9409915, 14 | US9718820, Compound 14)
Show SMILES CC(C)Oc1nc(cc2nc([nH]c12)-c1c(C#N)c(nn1C)C(C)(C)C)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C25H25F3N6O/c1-13(2)35-23-19-18(11-17(31-23)14-9-7-8-10-16(14)25(26,27)28)30-22(32-19)20-15(12-29)21(24(3,4)5)33-34(20)6/h7-11,13H,1-6H3,(H,30,32)
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n/an/a 1.20n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241689
PNG
(US9409915, 93 | US9718820, Compound 93)
Show SMILES CC(C)Oc1nc(cc2nc([nH]c12)-c1c(Cl)c(nn1C)C(C)(C)C)-c1ccccc1OC(F)(F)F
Show InChI InChI=1S/C24H25ClF3N5O2/c1-12(2)34-22-18-15(11-14(30-22)13-9-7-8-10-16(13)35-24(26,27)28)29-21(31-18)19-17(25)20(23(3,4)5)32-33(19)6/h7-12H,1-6H3,(H,29,31)
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US Patent
n/an/a 1.20n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241639
PNG
(US9409915, 22)
Show SMILES Cn1nc(c(C#N)c1-c1nc2cc(nc(N3CCCCC3)c2[nH]1)-c1ccccc1C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C27H28F3N7/c1-26(2,3)23-17(15-31)22(36(4)35-23)24-32-20-14-19(16-10-6-7-11-18(16)27(28,29)30)33-25(21(20)34-24)37-12-8-5-9-13-37/h6-7,10-11,14H,5,8-9,12-13H2,1-4H3,(H,32,34)
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US Patent
n/an/a 1.40n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241606
PNG
(US9409915, 57 | US9718820, Compound 57)
Show SMILES Cn1nc(c(Cl)c1-c1nc2cc(nc(OCCO)c2[nH]1)-c1ccccc1C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C23H23ClF3N5O2/c1-22(2,3)19-16(24)18(32(4)31-19)20-28-15-11-14(29-21(17(15)30-20)34-10-9-33)12-7-5-6-8-13(12)23(25,26)27/h5-8,11,33H,9-10H2,1-4H3,(H,28,30)
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US Patent
n/an/a 1.60n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241634
PNG
(US9409915, 17 | US9718820, Compound 17)
Show SMILES COc1nc(cc2nc([nH]c12)-c1c(C#N)c(nn1C)C(C)(C)C)-c1ccccc1Cl
Show InChI InChI=1S/C22H21ClN6O/c1-22(2,3)19-13(11-24)18(29(4)28-19)20-25-16-10-15(12-8-6-7-9-14(12)23)26-21(30-5)17(16)27-20/h6-10H,1-5H3,(H,25,27)
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n/an/a 1.70n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241680
PNG
(US9409915, 83 | US9718820, Compound 83)
Show SMILES Cn1nc(c(C#N)c1-c1nc2cc(nc(OCCO)c2[nH]1)-c1ccccc1Cl)C(C)(C)C
Show InChI InChI=1S/C23H23ClN6O2/c1-23(2,3)20-14(12-25)19(30(4)29-20)21-26-17-11-16(13-7-5-6-8-15(13)24)27-22(18(17)28-21)32-10-9-31/h5-8,11,31H,9-10H2,1-4H3,(H,26,28)
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n/an/a 1.80n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241632
PNG
(US9409915, 15 | US9718820, Compound 15)
Show SMILES Cn1nc(c(C#N)c1-c1nc2cc(nc(OCC(F)(F)F)c2[nH]1)-c1ccccc1C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C24H20F6N6O/c1-22(2,3)19-13(10-31)18(36(4)35-19)20-32-16-9-15(12-7-5-6-8-14(12)24(28,29)30)33-21(17(16)34-20)37-11-23(25,26)27/h5-9H,11H2,1-4H3,(H,32,34)
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US Patent
n/an/a 1.80n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241681
PNG
(US9409915, 84 | US9718820, Compound 84)
Show SMILES Cn1nc(c(C#N)c1-c1nc2cc(nc(OCCO)c2[nH]1)-c1ccccc1C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C24H23F3N6O2/c1-23(2,3)20-14(12-28)19(33(4)32-20)21-29-17-11-16(30-22(18(17)31-21)35-10-9-34)13-7-5-6-8-15(13)24(25,26)27/h5-8,11,34H,9-10H2,1-4H3,(H,29,31)
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US Patent
n/an/a 1.90n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241666
PNG
(US9409915, 58 | US9718820, Compound 58)
Show SMILES Cn1nc(c(Cl)c1-c1nc2cc(nc(OCCO)c2[nH]1)-c1ccccc1Cl)C(C)(C)C
Show InChI InChI=1S/C22H23Cl2N5O2/c1-22(2,3)19-16(24)18(29(4)28-19)20-25-15-11-14(12-7-5-6-8-13(12)23)26-21(17(15)27-20)31-10-9-30/h5-8,11,30H,9-10H2,1-4H3,(H,25,27)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241688
PNG
(US9409915, 92 | US9718820, Compound 92)
Show SMILES CC(C)Oc1nc(cc2nc([nH]c12)-c1c(Cl)c(nn1C)C(C)(C)C)-c1ccccc1F
Show InChI InChI=1S/C23H25ClFN5O/c1-12(2)31-22-18-16(11-15(27-22)13-9-7-8-10-14(13)25)26-21(28-18)19-17(24)20(23(3,4)5)29-30(19)6/h7-12H,1-6H3,(H,26,28)
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n/an/a 2.80n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241667
PNG
(US9409915, 63 | US9718820, Compound 63A)
Show SMILES Cn1nc(c(Cl)c1-c1nc2cc(nc(N3CCCCC3)c2[nH]1)-c1ccccc1C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C26H28ClF3N6/c1-25(2,3)22-19(27)21(35(4)34-22)23-31-18-14-17(15-10-6-7-11-16(15)26(28,29)30)32-24(20(18)33-23)36-12-8-5-9-13-36/h6-7,10-11,14H,5,8-9,12-13H2,1-4H3,(H,31,33)
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n/an/a 3.10n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241669
PNG
(US9409915, 65)
Show SMILES Cn1nc(c(C#N)c1-c1nc2nc(cc(N3CCOCC3)c2[nH]1)-c1ccccc1C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C26H26F3N7O/c1-25(2,3)22-16(14-30)21(35(4)34-22)24-32-20-19(36-9-11-37-12-10-36)13-18(31-23(20)33-24)15-7-5-6-8-17(15)26(27,28)29/h5-8,13H,9-12H2,1-4H3,(H,31,32,33)
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n/an/a 3.20n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241619
PNG
(US9409915, 11 | US9718820, Compound 11)
Show SMILES COc1nc(cc2nc([nH]c12)-c1c(Cl)c(nn1C)C(C)(C)C)-c1ccccc1Cl
Show InChI InChI=1S/C21H21Cl2N5O/c1-21(2,3)18-15(23)17(28(4)27-18)19-24-14-10-13(11-8-6-7-9-12(11)22)25-20(29-5)16(14)26-19/h6-10H,1-5H3,(H,24,26)
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n/an/a 3.5n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241687
PNG
(US9409915, 91 | US9718820, Compound 91)
Show SMILES Cn1nc(c(Cl)c1-c1nc2cc(nc(OCC(F)(F)F)c2[nH]1)-c1ccccc1F)C(C)(C)C
Show InChI InChI=1S/C22H20ClF4N5O/c1-21(2,3)18-15(23)17(32(4)31-18)19-28-14-9-13(11-7-5-6-8-12(11)24)29-20(16(14)30-19)33-10-22(25,26)27/h5-9H,10H2,1-4H3,(H,28,30)
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UniProtKB/TrEMBL

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UniChem
US Patent
n/an/a 3.80n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241663
PNG
(US9409915, 54 | US9718820, Compound 54)
Show SMILES Cn1nc(c(Cl)c1-c1nc2cc(nc(OCCN3CCOCC3)c2[nH]1)-c1ccccc1Cl)C(C)(C)C
Show InChI InChI=1S/C26H30Cl2N6O2/c1-26(2,3)23-20(28)22(33(4)32-23)24-29-19-15-18(16-7-5-6-8-17(16)27)30-25(21(19)31-24)36-14-11-34-9-12-35-13-10-34/h5-8,15H,9-14H2,1-4H3,(H,29,31)
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Janssen Pharmaceutica NV

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Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241691
PNG
(US9409915, 97 | US9718820, Compound 97)
Show SMILES COc1nc(cc2nc([nH]c12)-c1c(Cl)c(nn1C)C(C)(C)CF)-c1ccccc1Cl
Show InChI InChI=1S/C21H20Cl2FN5O/c1-21(2,10-24)18-15(23)17(29(3)28-18)19-25-14-9-13(11-7-5-6-8-12(11)22)26-20(30-4)16(14)27-19/h5-9H,10H2,1-4H3,(H,25,27)
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Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241622
PNG
(US9409915, 61)
Show SMILES Cn1nc(c(Cl)c1-c1nc2nc(cc(N3CCOCC3)c2[nH]1)-c1ccccc1C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C25H26ClF3N6O/c1-24(2,3)21-18(26)20(34(4)33-21)23-31-19-17(35-9-11-36-12-10-35)13-16(30-22(19)32-23)14-7-5-6-8-15(14)25(27,28)29/h5-8,13H,9-12H2,1-4H3,(H,30,31,32)
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Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241609
PNG
(US9409915, 103 | US9718820, Compound 103)
Show SMILES COc1nc(cc2nc(-c3c(Cl)c(nn3C)C(C)(C)C)n([Na])c12)-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C21H19Cl3N5O.Na/c1-21(2,3)18-15(24)17(29(4)28-18)19-25-13-9-12(26-20(30-5)16(13)27-19)14-10(22)7-6-8-11(14)23;/h6-9H,1-5H3;/q-1;+1
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Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241601
PNG
(US9409915, 9)
Show SMILES COc1nc(cc2nc(-c3c(Cl)c(nn3C)C(C)(C)C)n([Na])c12)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C22H20ClF3N5O.Na/c1-21(2,3)18-15(23)17(31(4)30-18)19-27-14-10-13(28-20(32-5)16(14)29-19)11-8-6-7-9-12(11)22(24,25)26;/h6-10H,1-5H3;/q-1;+1
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Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241675
PNG
(US9409915, 76 | US9718820, Compound 76)
Show SMILES COCCOc1cc(nc2nc([nH]c12)-c1c(Cl)c(nn1C)C(C)(C)C)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C24H25ClF3N5O2/c1-23(2,3)20-17(25)19(33(4)32-20)22-30-18-16(35-11-10-34-5)12-15(29-21(18)31-22)13-8-6-7-9-14(13)24(26,27)28/h6-9,12H,10-11H2,1-5H3,(H,29,30,31)
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Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241600
PNG
(US9409915, 8)
Show SMILES COc1nc(nc2nc(-c3cc(no3)C(C)(C)C)n([Na])c12)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C20H17F3N5O2.Na/c1-19(2,3)13-9-12(30-28-13)16-24-14-17(26-16)25-15(27-18(14)29-4)10-7-5-6-8-11(10)20(21,22)23;/h5-9H,1-4H3;/q-1;+1
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Janssen Pharmaceutica NV

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Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241659
PNG
(US9409915, 49 | US9718820, Compound 49)
Show SMILES Cn1nc(c(Cl)c1-c1nc2cc(nc(OCCN3CCOCC3)c2[nH]1)-c1ccccc1C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C27H30ClF3N6O2/c1-26(2,3)23-20(28)22(36(4)35-23)24-32-19-15-18(16-7-5-6-8-17(16)27(29,30)31)33-25(21(19)34-24)39-14-11-37-9-12-38-13-10-37/h5-8,15H,9-14H2,1-4H3,(H,32,34)
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Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241670
PNG
(US9409915, 66 | US9718820, Compound 66)
Show SMILES Cn1nc(c(Cl)c1-c1nc2cc(nc(N3CCCC3)c2[nH]1)-c1ccccc1C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C25H26ClF3N6/c1-24(2,3)21-18(26)20(34(4)33-21)22-30-17-13-16(14-9-5-6-10-15(14)25(27,28)29)31-23(19(17)32-22)35-11-7-8-12-35/h5-6,9-10,13H,7-8,11-12H2,1-4H3,(H,30,32)
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Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241640
PNG
(US9409915, 24 | US9718820, Compound 24)
Show SMILES CN1CCN(CC1)c1nc(cc2nc([nH]c12)-c1c(C#N)c(nn1C)C(C)(C)C)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C27H29F3N8/c1-26(2,3)23-17(15-31)22(37(5)35-23)24-32-20-14-19(16-8-6-7-9-18(16)27(28,29)30)33-25(21(20)34-24)38-12-10-36(4)11-13-38/h6-9,14H,10-13H2,1-5H3,(H,32,34)
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Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241646
PNG
(US9409915, 32)
Show SMILES Cn1nc(c(Cl)c1-c1nc2nc(ccc2[nH]1)-c1ccccc1C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C21H19ClF3N5/c1-20(2,3)17-15(22)16(30(4)29-17)19-27-14-10-9-13(26-18(14)28-19)11-7-5-6-8-12(11)21(23,24)25/h5-10H,1-4H3,(H,26,27,28)
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Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241635
PNG
(US9409915, 18)
Show SMILES COc1nc(cc2nc([nH]c12)-c1c2c(CCC22CCCCC2)nn1C)-c1ccccc1Cl
Show InChI InChI=1S/C25H26ClN5O/c1-31-22(20-17(30-31)10-13-25(20)11-6-3-7-12-25)23-27-19-14-18(15-8-4-5-9-16(15)26)28-24(32-2)21(19)29-23/h4-5,8-9,14H,3,6-7,10-13H2,1-2H3,(H,27,29)
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Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241612
PNG
(US9409915, 71 | US9718820, Compound 71)
Show SMILES Cn1nc(c(Cl)c1-c1nc2cc(nc(Cl)c2[nH]1)-c1ccccc1C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C21H18Cl2F3N5/c1-20(2,3)17-14(22)16(31(4)30-17)19-28-13-9-12(27-18(23)15(13)29-19)10-7-5-6-8-11(10)21(24,25)26/h5-9H,1-4H3,(H,28,29)
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Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241618
PNG
(US9409915, 28 | US9718820, Compound 28)
Show SMILES CN1CCN(CC1)c1nc(cc2nc([nH]c12)-c1c(Cl)c(nn1C)C(C)(C)C)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C26H29ClF3N7/c1-25(2,3)22-19(27)21(36(5)34-22)23-31-18-14-17(15-8-6-7-9-16(15)26(28,29)30)32-24(20(18)33-23)37-12-10-35(4)11-13-37/h6-9,14H,10-13H2,1-5H3,(H,31,33)
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Janssen Pharmaceutica NV

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Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241629
PNG
(US9409915, 12 | US9718820, Compound 12)
Show SMILES COc1nc(cc2nc([nH]c12)-c1cc(nn1C)C(C)(C)C)-c1ccccc1Cl
Show InChI InChI=1S/C21H22ClN5O/c1-21(2,3)17-11-16(27(4)26-17)19-23-15-10-14(12-8-6-7-9-13(12)22)24-20(28-5)18(15)25-19/h6-11H,1-5H3,(H,23,25)
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Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241641
PNG
(US9409915, 25)
Show SMILES Cn1nc(c(Cl)c1-c1nc2nc(ccc2[nH]1)-c1ccccc1OC(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C21H19ClF3N5O/c1-20(2,3)17-15(22)16(30(4)29-17)19-27-13-10-9-12(26-18(13)28-19)11-7-5-6-8-14(11)31-21(23,24)25/h5-10H,1-4H3,(H,26,27,28)
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Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241624
PNG
(US9409915, 2)
Show SMILES COc1nc(cc2nc([nH]c12)-c1c(Cl)c(nn1C)C(C)(C)C)-c1ccccc1OC(F)(F)F
Show InChI InChI=1S/C22H21ClF3N5O2/c1-21(2,3)18-15(23)17(31(4)30-18)19-27-13-10-12(28-20(32-5)16(13)29-19)11-8-6-7-9-14(11)33-22(24,25)26/h6-10H,1-5H3,(H,27,29)
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Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241692
PNG
(US9409915, 98 | US9718820, Compound 98)
Show SMILES COc1nc(cc2nc([nH]c12)-c1csc(c1)C(C)C)-c1ccccc1Cl
Show InChI InChI=1S/C20H18ClN3OS/c1-11(2)17-8-12(10-26-17)19-22-16-9-15(13-6-4-5-7-14(13)21)23-20(25-3)18(16)24-19/h4-11H,1-3H3,(H,22,24)
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Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241668
PNG
(US9409915, 64 | US9718820, Compound 64)
Show SMILES CC(C)(C)c1noc(-c2nc3cc(nc(N4CCOCC4)c3[nH]2)-c2ccccc2C(F)(F)F)c1C#N
Show InChI InChI=1S/C25H23F3N6O2/c1-24(2,3)21-15(13-29)20(36-33-21)22-30-18-12-17(14-6-4-5-7-16(14)25(26,27)28)31-23(19(18)32-22)34-8-10-35-11-9-34/h4-7,12H,8-11H2,1-3H3,(H,30,32)
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Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241628
PNG
(US9409915, 10 | US9718820, Compound 10)
Show SMILES CC(C)(C)c1cc(on1)-c1nc2nc(cc(c2[nH]1)C(F)(F)F)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C21H16F6N4O/c1-19(2,3)15-9-14(32-31-15)17-29-16-12(21(25,26)27)8-13(28-18(16)30-17)10-6-4-5-7-11(10)20(22,23)24/h4-9H,1-3H3,(H,28,29,30)
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Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241597
PNG
(US9409915, 5 | US9718820, Compound 5)
Show SMILES Cn1nc(c(Cl)c1-c1nc2nc(cc(Cl)c2n1[Na])-c1ccccc1C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C21H17Cl2F3N5.Na/c1-20(2,3)17-14(23)16(31(4)30-17)19-28-15-12(22)9-13(27-18(15)29-19)10-7-5-6-8-11(10)21(24,25)26;/h5-9H,1-4H3;/q-1;+1
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Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241677
PNG
(US9409915, 78 | US9718820, Compound 78)
Show SMILES COc1nc(cc2nc([nH]c12)-c1c(F)c(nn1C)C(C)(C)C)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C22H21F4N5O/c1-21(2,3)18-15(23)17(31(4)30-18)19-27-14-10-13(28-20(32-5)16(14)29-19)11-8-6-7-9-12(11)22(24,25)26/h6-10H,1-5H3,(H,27,29)
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Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241598
PNG
(US9409915, 3 | US9718820, Compound 3)
Show SMILES Cc1nc(nc2nc([nH]c12)-c1c(Cl)c(nn1C)C(C)(C)C)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C21H20ClF3N6/c1-10-14-18(28-17(26-10)11-8-6-7-9-12(11)21(23,24)25)29-19(27-14)15-13(22)16(20(2,3)4)30-31(15)5/h6-9H,1-5H3,(H,26,27,28,29)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241616
PNG
(US9409915, 31 | US9718820, Compound 31)
Show SMILES CC(C)(C)c1cc(on1)-c1nc2nc(ccc2[nH]1)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C20H17F3N4O/c1-19(2,3)16-10-15(28-27-16)18-25-14-9-8-13(24-17(14)26-18)11-6-4-5-7-12(11)20(21,22)23/h4-10H,1-3H3,(H,24,25,26)
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Janssen Pharmaceutica NV

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Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241703
PNG
(US9409915, 112)
Show SMILES COCCOc1cc(nc2nc([nH]c12)-c1cc(nn1C)C(C)(C)C)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C24H26F3N5O2/c1-23(2,3)19-13-17(32(4)31-19)21-29-20-18(34-11-10-33-5)12-16(28-22(20)30-21)14-8-6-7-9-15(14)24(25,26)27/h6-9,12-13H,10-11H2,1-5H3,(H,28,29,30)
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Janssen Pharmaceutica NV

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Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241656
PNG
(US9409915, 46)
Show SMILES Cn1nc(c(Cl)c1-c1nc2cc(ncc2[nH]1)-c1ccccc1C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C21H19ClF3N5/c1-20(2,3)18-16(22)17(30(4)29-18)19-27-14-9-13(26-10-15(14)28-19)11-7-5-6-8-12(11)21(23,24)25/h5-10H,1-4H3,(H,27,28)
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Janssen Pharmaceutica NV

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Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241610
PNG
(US9409915, 79 | US9718820, Compound 80)
Show SMILES COc1c(nn(C)c1-c1nc2cc(nc(OC)c2[nH]1)-c1ccccc1C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C23H24F3N5O2/c1-22(2,3)19-18(32-5)17(31(4)30-19)20-27-15-11-14(28-21(33-6)16(15)29-20)12-9-7-8-10-13(12)23(24,25)26/h7-11H,1-6H3,(H,27,29)
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Janssen Pharmaceutica NV

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Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241676
PNG
(US9409915, 77 | US9718820, Compound 77)
Show SMILES COc1nc(cc2nc([nH]c12)-c1c(Cl)c(nn1C)C(C)(C)C)-c1ccccc1F
Show InChI InChI=1S/C21H21ClFN5O/c1-21(2,3)18-15(22)17(28(4)27-18)19-24-14-10-13(11-8-6-7-9-12(11)23)25-20(29-5)16(14)26-19/h6-10H,1-5H3,(H,24,26)
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Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241654
PNG
(US9409915, 43)
Show SMILES Cn1nc(c(Cl)c1-c1nc2cc(ncc2[nH]1)-c1ccccc1F)C(C)(C)C
Show InChI InChI=1S/C20H19ClFN5/c1-20(2,3)18-16(21)17(27(4)26-18)19-24-14-9-13(23-10-15(14)25-19)11-7-5-6-8-12(11)22/h5-10H,1-4H3,(H,24,25)
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Janssen Pharmaceutica NV

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Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241605
PNG
(US9409915, 94 | US9718820, Compound 94)
Show SMILES Cn1nc(c(Cl)c1-c1nc2nc(cnc2[nH]1)-c1ccccc1OC(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C20H18ClF3N6O/c1-19(2,3)15-13(21)14(30(4)29-15)16-27-17-18(28-16)26-11(9-25-17)10-7-5-6-8-12(10)31-20(22,23)24/h5-9H,1-4H3,(H,25,26,27,28)
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Janssen Pharmaceutica NV

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Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241665
PNG
(US9409915, 56 | US9718820, Compound 56)
Show SMILES CN(C)CCOc1nc(cc2nc([nH]c12)-c1c(Cl)c(nn1C)C(C)(C)C)-c1ccccc1Cl
Show InChI InChI=1S/C24H28Cl2N6O/c1-24(2,3)21-18(26)20(32(6)30-21)22-27-17-13-16(14-9-7-8-10-15(14)25)28-23(19(17)29-22)33-12-11-31(4)5/h7-10,13H,11-12H2,1-6H3,(H,27,29)
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Janssen Pharmaceutica NV

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Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241702
PNG
(US9409915, 110 | US9718820, Compound 110)
Show SMILES Cn1nc(c(Cl)c1-c1nc2nc(cnc2[nH]1)-c1ccccc1Cl)C(C)(C)C
Show InChI InChI=1S/C19H18Cl2N6/c1-19(2,3)15-13(21)14(27(4)26-15)16-24-17-18(25-16)23-12(9-22-17)10-7-5-6-8-11(10)20/h5-9H,1-4H3,(H,22,23,24,25)
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Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241611
PNG
(US9409915, 75 | US9718820, Compound 75)
Show SMILES Cn1nc(c(C#N)c1-c1nc2cc(nc(Cl)c2[nH]1)-c1ccccc1C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C22H18ClF3N6/c1-21(2,3)18-12(10-27)17(32(4)31-18)20-29-15-9-14(28-19(23)16(15)30-20)11-7-5-6-8-13(11)22(24,25)26/h5-9H,1-4H3,(H,29,30)
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Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241621
PNG
(US9409915, 60 | US9718820, Compound 60)
Show SMILES Cn1nc(c(Cl)c1-c1nc2cc(nc(C#N)c2[nH]1)-c1ccccc1C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C22H18ClF3N6/c1-21(2,3)19-16(23)18(32(4)31-19)20-29-14-9-13(28-15(10-27)17(14)30-20)11-7-5-6-8-12(11)22(24,25)26/h5-9H,1-4H3,(H,29,30)
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Janssen Pharmaceutica NV

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Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241614
PNG
(US9409915, 23)
Show SMILES Cn1nc(c(Cl)c1-c1nc2nc(ccc2[nH]1)-c1ccccc1Cl)C(C)(C)C
Show InChI InChI=1S/C20H19Cl2N5/c1-20(2,3)17-15(22)16(27(4)26-17)19-24-14-10-9-13(23-18(14)25-19)11-7-5-6-8-12(11)21/h5-10H,1-4H3,(H,23,24,25)
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Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241655
PNG
(US9409915, 45 | US9718820, Compound 45)
Show SMILES Cn1nc(c(C#N)c1-c1nc2cc(ncc2[nH]1)-c1ccccc1C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C22H19F3N6/c1-21(2,3)19-13(10-26)18(31(4)30-19)20-28-16-9-15(27-11-17(16)29-20)12-7-5-6-8-14(12)22(23,24)25/h5-9,11H,1-4H3,(H,28,29)
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Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241608
PNG
(US9409915, 53 | US9718820, Compound 53)
Show SMILES CN(C)CCOc1nc(cc2nc([nH]c12)-c1c(Cl)c(nn1C)C(C)(C)C)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C25H28ClF3N6O/c1-24(2,3)21-18(26)20(35(6)33-21)22-30-17-13-16(14-9-7-8-10-15(14)25(27,28)29)31-23(19(17)32-22)36-12-11-34(4)5/h7-10,13H,11-12H2,1-6H3,(H,30,32)
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Janssen Pharmaceutica NV

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Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241603
PNG
(US9409915, 95 | US9718820, Compound 95)
Show SMILES Cn1nc(c(Cl)c1-c1nc2nc(cnc2[nH]1)-c1ccccc1C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C20H18ClF3N6/c1-19(2,3)15-13(21)14(30(4)29-15)16-27-17-18(28-16)26-12(9-25-17)10-7-5-6-8-11(10)20(22,23)24/h5-9H,1-4H3,(H,25,26,27,28)
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Janssen Pharmaceutica NV

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Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241625
PNG
(US9409915, 1)
Show SMILES Cn1nc(c(Cl)c1-c1nc2nc(cc(c2[nH]1)C(F)(F)F)-c1ccccc1C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C22H18ClF6N5/c1-20(2,3)17-14(23)16(34(4)33-17)19-31-15-12(22(27,28)29)9-13(30-18(15)32-19)10-7-5-6-8-11(10)21(24,25)26/h5-9H,1-4H3,(H,30,31,32)
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Janssen Pharmaceutica NV

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Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241697
PNG
(US9409915, 105 | US9718820, Compound 105)
Show SMILES COc1nc(cc2nc([nH]c12)-c1cc(cs1)C(C)C)-c1ccccc1Cl
Show InChI InChI=1S/C20H18ClN3OS/c1-11(2)12-8-17(26-10-12)19-22-16-9-15(13-6-4-5-7-14(13)21)23-20(25-3)18(16)24-19/h4-11H,1-3H3,(H,22,24)
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Janssen Pharmaceutica NV

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Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241613
PNG
(US9409915, 73 | US9718820, Compound 73)
Show SMILES CC(C)(C)c1cc(on1)-c1nc2cc(nc(Cl)c2[nH]1)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C20H16ClF3N4O/c1-19(2,3)15-9-14(29-28-15)18-26-13-8-12(25-17(21)16(13)27-18)10-6-4-5-7-11(10)20(22,23)24/h4-9H,1-3H3,(H,26,27)
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Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241604
PNG
(US9409915, 62)
Show SMILES COc1cc(nc2nc([nH]c12)-c1c(Cl)c(nn1C)C(C)(C)C)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C22H21ClF3N5O/c1-21(2,3)18-15(23)17(31(4)30-18)20-28-16-14(32-5)10-13(27-19(16)29-20)11-8-6-7-9-12(11)22(24,25)26/h6-10H,1-5H3,(H,27,28,29)
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Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241693
PNG
(US9409915, 99)
Show SMILES COc1nc(cc2nc([nH]c12)-c1cc(co1)C(C)(C)C)-c1ccccc1Cl
Show InChI InChI=1S/C21H20ClN3O2/c1-21(2,3)12-9-17(27-11-12)19-23-16-10-15(13-7-5-6-8-14(13)22)24-20(26-4)18(16)25-19/h5-11H,1-4H3,(H,23,25)
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Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241644
PNG
(US9409915, 29 | US9718820, Compound 29)
Show SMILES CC(C)(C)c1cc(on1)-c1nc2nc(ccc2[nH]1)-c1ccccc1OC(F)(F)F
Show InChI InChI=1S/C20H17F3N4O2/c1-19(2,3)16-10-15(29-27-16)18-25-13-9-8-12(24-17(13)26-18)11-6-4-5-7-14(11)28-20(21,22)23/h4-10H,1-3H3,(H,24,25,26)
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Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241695
PNG
(US9409915, 101)
Show SMILES COc1nc(cc2nc([nH]c12)-c1cc(c(Br)o1)C(C)(C)C)-c1ccccc1Cl
Show InChI InChI=1S/C21H19BrClN3O2/c1-21(2,3)12-9-16(28-18(12)22)19-24-15-10-14(11-7-5-6-8-13(11)23)25-20(27-4)17(15)26-19/h5-10H,1-4H3,(H,24,26)
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Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241642
PNG
(US9409915, 26)
Show SMILES CC(C)(C)c1cc(on1)-c1nc2nc(ccc2[nH]1)-c1ccccc1Cl
Show InChI InChI=1S/C19H17ClN4O/c1-19(2,3)16-10-15(25-24-16)18-22-14-9-8-13(21-17(14)23-18)11-6-4-5-7-12(11)20/h4-10H,1-3H3,(H,21,22,23)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241653
PNG
(US9409915, 44 | US9718820, Compound 44)
Show SMILES Cn1nc(c(C#N)c1-c1nc2cc(ncc2[nH]1)-c1ccccc1F)C(C)(C)C
Show InChI InChI=1S/C21H19FN6/c1-21(2,3)19-13(10-23)18(28(4)27-19)20-25-16-9-15(24-11-17(16)26-20)12-7-5-6-8-14(12)22/h5-9,11H,1-4H3,(H,25,26)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241599
PNG
(US9409915, 7 | US9718820, Compound 7)
Show SMILES CC(C)(C)c1cc(on1)-c1nc2nc(cc(Cl)c2[nH]1)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C20H16ClF3N4O/c1-19(2,3)15-9-14(29-28-15)17-26-16-12(21)8-13(25-18(16)27-17)10-6-4-5-7-11(10)20(22,23)24/h4-9H,1-3H3,(H,25,26,27)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241647
PNG
(US9409915, 33)
Show SMILES Cn1nc(c(Cl)c1-c1nc2nc(ccc2[nH]1)-c1ccccc1F)C(C)(C)C
Show InChI InChI=1S/C20H19ClFN5/c1-20(2,3)17-15(21)16(27(4)26-17)19-24-14-10-9-13(23-18(14)25-19)11-7-5-6-8-12(11)22/h5-10H,1-4H3,(H,23,24,25)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241678
PNG
(US9409915, 80)
Show SMILES COc1nc(cc2nc([nH]c12)-c1cc(nn1C)C(C)(C)C)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C22H22F3N5O/c1-21(2,3)17-11-16(30(4)29-17)19-26-15-10-14(27-20(31-5)18(15)28-19)12-8-6-7-9-13(12)22(23,24)25/h6-11H,1-5H3,(H,26,28)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241630
PNG
(US9409915, 13)
Show SMILES COc1nc(cc2[nH]c(nc12)-c1onc(c1C#N)C(C)(C)C)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C22H18F3N5O2/c1-21(2,3)18-12(10-26)17(32-30-18)19-27-15-9-14(28-20(31-4)16(15)29-19)11-7-5-6-8-13(11)22(23,24)25/h5-9H,1-4H3,(H,27,29)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241623
PNG
(US9409915, 41)
Show SMILES Cn1nc(cc1-c1nc2cc(ncc2[nH]1)-c1ccccc1Cl)C(C)(C)C
Show InChI InChI=1S/C20H20ClN5/c1-20(2,3)18-10-17(26(4)25-18)19-23-15-9-14(22-11-16(15)24-19)12-7-5-6-8-13(12)21/h5-11H,1-4H3,(H,23,24)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241664
PNG
(US9409915, 55 | US9718820, Compound 55)
Show SMILES CN1CCN(CCOc2nc(cc3nc([nH]c23)-c2c(Cl)c(nn2C)C(C)(C)C)-c2ccccc2Cl)CC1
Show InChI InChI=1S/C27H33Cl2N7O/c1-27(2,3)24-21(29)23(35(5)33-24)25-30-20-16-19(17-8-6-7-9-18(17)28)31-26(22(20)32-25)37-15-14-36-12-10-34(4)11-13-36/h6-9,16H,10-15H2,1-5H3,(H,30,32)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241660
PNG
(US9409915, 50 | US9718820, Compound 50)
Show SMILES CN1CCN(CCOc2nc(cc3nc([nH]c23)-c2c(Cl)c(nn2C)C(C)(C)C)-c2ccccc2C(F)(F)F)CC1
Show InChI InChI=1S/C28H33ClF3N7O/c1-27(2,3)24-21(29)23(38(5)36-24)25-33-20-16-19(17-8-6-7-9-18(17)28(30,31)32)34-26(22(20)35-25)40-15-14-39-12-10-37(4)11-13-39/h6-9,16H,10-15H2,1-5H3,(H,33,35)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241651
PNG
(US9409915, 40 | US9718820, Compound 41)
Show SMILES Cn1nc(cc1-c1nc2cc(ncc2[nH]1)-c1ccccc1C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C21H20F3N5/c1-20(2,3)18-10-17(29(4)28-18)19-26-15-9-14(25-11-16(15)27-19)12-7-5-6-8-13(12)21(22,23)24/h5-11H,1-4H3,(H,26,27)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241652
PNG
(US9409915, 42 | US9718820, Compound 42)
Show SMILES Cn1nc(cc1-c1nc2cc(ncc2[nH]1)-c1ccccc1F)C(C)(C)C
Show InChI InChI=1S/C20H20FN5/c1-20(2,3)18-10-17(26(4)25-18)19-23-15-9-14(22-11-16(15)24-19)12-7-5-6-8-13(12)21/h5-11H,1-4H3,(H,23,24)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241694
PNG
(US9409915, 100 | US9718820, Compound 100)
Show SMILES COc1nc(cc2nc([nH]c12)-c1cnn(c1C)C(C)(C)C)-c1ccccc1Cl
Show InChI InChI=1S/C21H22ClN5O/c1-12-14(11-23-27(12)21(2,3)4)19-24-17-10-16(13-8-6-7-9-15(13)22)25-20(28-5)18(17)26-19/h6-11H,1-5H3,(H,24,26)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241673
PNG
(US9409915, 72 | US9718820, Compound 72)
Show SMILES Cn1nc2c(CCC22CCCCC2)c1-c1nc2cc(nc(Cl)c2[nH]1)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C25H23ClF3N5/c1-34-20(15-9-12-24(21(15)33-34)10-5-2-6-11-24)23-31-18-13-17(30-22(26)19(18)32-23)14-7-3-4-8-16(14)25(27,28)29/h3-4,7-8,13H,2,5-6,9-12H2,1H3,(H,31,32)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241627
PNG
(US9409915, 6)
Show SMILES Cn1nc(cc1-c1nc2nc(cc(Cl)c2[nH]1)-c1ccccc1C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C21H19ClF3N5/c1-20(2,3)16-10-15(30(4)29-16)18-27-17-13(22)9-14(26-19(17)28-18)11-7-5-6-8-12(11)21(23,24)25/h5-10H,1-4H3,(H,26,27,28)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241661
PNG
(US9409915, 51 | US9718820, Compound 51)
Show SMILES Cn1nc(c(Cl)c1-c1nc2cc(nc(OCCN3CCCC3)c2[nH]1)-c1ccccc1Cl)C(C)(C)C
Show InChI InChI=1S/C26H30Cl2N6O/c1-26(2,3)23-20(28)22(33(4)32-23)24-29-19-15-18(16-9-5-6-10-17(16)27)30-25(21(19)31-24)35-14-13-34-11-7-8-12-34/h5-6,9-10,15H,7-8,11-14H2,1-4H3,(H,29,31)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241650
PNG
(US9409915, 39)
Show SMILES Cn1nc(cc1-c1nc2cc(ncc2[nH]1)-c1ccccc1OC(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C21H20F3N5O/c1-20(2,3)18-10-16(29(4)28-18)19-26-14-9-13(25-11-15(14)27-19)12-7-5-6-8-17(12)30-21(22,23)24/h5-11H,1-4H3,(H,26,27)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241617
PNG
(US9409915, 34 | US9718820, Compound 34)
Show SMILES Cn1nc(cc1-c1nc2nc(ccc2[nH]1)-c1ccccc1C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C21H20F3N5/c1-20(2,3)17-11-16(29(4)28-17)19-26-15-10-9-14(25-18(15)27-19)12-7-5-6-8-13(12)21(22,23)24/h5-11H,1-4H3,(H,25,26,27)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241662
PNG
(US9409915, 52 | US9718820, Compound 52)
Show SMILES Cn1nc(c(Cl)c1-c1nc2cc(nc(OCCN3CCCC3)c2[nH]1)-c1ccccc1C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C27H30ClF3N6O/c1-26(2,3)23-20(28)22(36(4)35-23)24-32-19-15-18(16-9-5-6-10-17(16)27(29,30)31)33-25(21(19)34-24)38-14-13-37-11-7-8-12-37/h5-6,9-10,15H,7-8,11-14H2,1-4H3,(H,32,34)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241645
PNG
(US9409915, 30 | US9718820, Compound 30)
Show SMILES CC(C)(C)c1cc(on1)-c1nc2nc(ccc2[nH]1)-c1ccccc1F
Show InChI InChI=1S/C19H17FN4O/c1-19(2,3)16-10-15(25-24-16)18-22-14-9-8-13(21-17(14)23-18)11-6-4-5-7-12(11)20/h4-10H,1-3H3,(H,21,22,23)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241674
PNG
(US9409915, 74 | US9718820, Compound 74)
Show SMILES Cn1nc(cc1-c1nc2cc(nc(Cl)c2[nH]1)-c1ccccc1C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C21H19ClF3N5/c1-20(2,3)16-10-15(30(4)29-16)19-27-14-9-13(26-18(22)17(14)28-19)11-7-5-6-8-12(11)21(23,24)25/h5-10H,1-4H3,(H,27,28)
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Janssen Pharmaceutica NV

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Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241679
PNG
(US9409915, 81 | US9718820, Compound 81)
Show SMILES COc1cc(nc2nc([nH]c12)-c1cc(nn1C)C(C)(C)C)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C22H22F3N5O/c1-21(2,3)17-11-15(30(4)29-17)19-27-18-16(31-5)10-14(26-20(18)28-19)12-8-6-7-9-13(12)22(23,24)25/h6-11H,1-5H3,(H,26,27,28)
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Janssen Pharmaceutica NV

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Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241696
PNG
(US9409915, 102 | US9718820, Compound 102)
Show SMILES COc1nc(cc2nc([nH]c12)-c1cnn(c1)C(C)(C)C)-c1ccccc1Cl
Show InChI InChI=1S/C20H20ClN5O/c1-20(2,3)26-11-12(10-22-26)18-23-16-9-15(13-7-5-6-8-14(13)21)24-19(27-4)17(16)25-18/h5-11H,1-4H3,(H,23,25)
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Janssen Pharmaceutica NV

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Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241643
PNG
(US9409915, 27)
Show SMILES Cn1nc(cc1-c1nc2nc(ccc2[nH]1)-c1ccccc1Cl)C(C)(C)C
Show InChI InChI=1S/C20H20ClN5/c1-20(2,3)17-11-16(26(4)25-17)19-23-15-10-9-14(22-18(15)24-19)12-7-5-6-8-13(12)21/h5-11H,1-4H3,(H,22,23,24)
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Janssen Pharmaceutica NV

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Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241684
PNG
(US9409915, 87 | US9718820, Compound 87)
Show SMILES Cn1nc(c(Cl)c1-c1nc2cc(nc(OCC(O)=O)c2[nH]1)-c1ccccc1Cl)C(C)(C)C
Show InChI InChI=1S/C22H21Cl2N5O3/c1-22(2,3)19-16(24)18(29(4)28-19)20-25-14-9-13(11-7-5-6-8-12(11)23)26-21(17(14)27-20)32-10-15(30)31/h5-9H,10H2,1-4H3,(H,25,27)(H,30,31)
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UniProtKB/TrEMBL

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PC cid
PC sid
UniChem
US Patent
n/an/a 131n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


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* indicates data uncertainty>20%