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Patent code US9409917

Compile Data Set for Download or QSAR
Found 118 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241720
PNG
(US9409917, 17 | US9409917, 18)
Show SMILES Cc1cc(Cl)cc(Cl)c1CNC(=O)C1CCOc2ncccc12
Show InChI InChI=1S/C17H16Cl2N2O2/c1-10-7-11(18)8-15(19)14(10)9-21-16(22)12-4-6-23-17-13(12)3-2-5-20-17/h2-3,5,7-8,12H,4,6,9H2,1H3,(H,21,22)
PDB

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US Patent
n/an/a 1.30n/an/an/an/an/an/a



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241779
PNG
(US9409917, 104 | US9409917, 105 | US9409917, 76 | ...)
Show SMILES Clc1cc2CCC(NC(=O)C3COc4ncccc34)c2c(Cl)c1
Show InChI InChI=1S/C17H14Cl2N2O2/c18-10-6-9-3-4-14(15(9)13(19)7-10)21-16(22)12-8-23-17-11(12)2-1-5-20-17/h1-2,5-7,12,14H,3-4,8H2,(H,21,22)
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n/an/a 1.30n/an/an/an/an/an/a



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241725
PNG
(US9409917, 22)
Show SMILES CCc1cc(Cl)cc(Cl)c1CNC(=O)C1COc2ncccc12
Show InChI InChI=1S/C17H16Cl2N2O2/c1-2-10-6-11(18)7-15(19)13(10)8-21-16(22)14-9-23-17-12(14)4-3-5-20-17/h3-7,14H,2,8-9H2,1H3,(H,21,22)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241720
PNG
(US9409917, 17 | US9409917, 18)
Show SMILES Cc1cc(Cl)cc(Cl)c1CNC(=O)C1CCOc2ncccc12
Show InChI InChI=1S/C17H16Cl2N2O2/c1-10-7-11(18)8-15(19)14(10)9-21-16(22)12-4-6-23-17-13(12)3-2-5-20-17/h2-3,5,7-8,12H,4,6,9H2,1H3,(H,21,22)
PDB

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n/an/a 1.60n/an/an/an/an/an/a



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241706
PNG
(US9409917, 3 | US9409917, 4 | US9409917, 96 | US94...)
Show SMILES Cc1cc(Cl)cc(Cl)c1CNC(=O)C1COc2ncccc12
Show InChI InChI=1S/C16H14Cl2N2O2/c1-9-5-10(17)6-14(18)12(9)7-20-15(21)13-8-22-16-11(13)3-2-4-19-16/h2-6,13H,7-8H2,1H3,(H,20,21)
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n/an/a 1.80n/an/an/an/an/an/a



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241743
PNG
(US9409917, 40)
Show SMILES FC(F)(F)c1cccc(CNC(=O)C2CCOc3ncccc23)c1Cl
Show InChI InChI=1S/C17H14ClF3N2O2/c18-14-10(3-1-5-13(14)17(19,20)21)9-23-15(24)11-6-8-25-16-12(11)4-2-7-22-16/h1-5,7,11H,6,8-9H2,(H,23,24)
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n/an/a 2.70n/an/an/an/an/an/a



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241727
PNG
(US9409917, 24 | US9409917, 25)
Show SMILES OCc1cc(Cl)cc(Cl)c1CNC(=O)C1COc2ncccc12
Show InChI InChI=1S/C16H14Cl2N2O3/c17-10-4-9(7-21)12(14(18)5-10)6-20-15(22)13-8-23-16-11(13)2-1-3-19-16/h1-5,13,21H,6-8H2,(H,20,22)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241706
PNG
(US9409917, 3 | US9409917, 4 | US9409917, 96 | US94...)
Show SMILES Cc1cc(Cl)cc(Cl)c1CNC(=O)C1COc2ncccc12
Show InChI InChI=1S/C16H14Cl2N2O2/c1-9-5-10(17)6-14(18)12(9)7-20-15(21)13-8-22-16-11(13)3-2-4-19-16/h2-6,13H,7-8H2,1H3,(H,20,21)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241706
PNG
(US9409917, 3 | US9409917, 4 | US9409917, 96 | US94...)
Show SMILES Cc1cc(Cl)cc(Cl)c1CNC(=O)C1COc2ncccc12
Show InChI InChI=1S/C16H14Cl2N2O2/c1-9-5-10(17)6-14(18)12(9)7-20-15(21)13-8-22-16-11(13)3-2-4-19-16/h2-6,13H,7-8H2,1H3,(H,20,21)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241715
PNG
(US9409917, 12)
Show SMILES Cc1cc(Cl)cc(Cl)c1CNC(=O)C1(F)CCOc2ncccc12
Show InChI InChI=1S/C17H15Cl2FN2O2/c1-10-7-11(18)8-14(19)12(10)9-22-16(23)17(20)4-6-24-15-13(17)3-2-5-21-15/h2-3,5,7-8H,4,6,9H2,1H3,(H,22,23)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241782
PNG
(US9409917, 79 | US9409917, 80)
Show SMILES Clc1cc(Cl)c(CNC(=O)C2COc3ncccc23)c(Br)c1
Show InChI InChI=1S/C15H11BrCl2N2O2/c16-12-4-8(17)5-13(18)10(12)6-20-14(21)11-7-22-15-9(11)2-1-3-19-15/h1-5,11H,6-7H2,(H,20,21)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241779
PNG
(US9409917, 104 | US9409917, 105 | US9409917, 76 | ...)
Show SMILES Clc1cc2CCC(NC(=O)C3COc4ncccc34)c2c(Cl)c1
Show InChI InChI=1S/C17H14Cl2N2O2/c18-10-6-9-3-4-14(15(9)13(19)7-10)21-16(22)12-8-23-17-11(12)2-1-5-20-17/h1-2,5-7,12,14H,3-4,8H2,(H,21,22)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241714
PNG
(US9409917, 11)
Show SMILES Cc1cc(Cl)cc(Cl)c1CNC(=O)C1(F)COc2ncccc12
Show InChI InChI=1S/C16H13Cl2FN2O2/c1-9-5-10(17)6-13(18)11(9)7-21-15(22)16(19)8-23-14-12(16)3-2-4-20-14/h2-6H,7-8H2,1H3,(H,21,22)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241804
PNG
(US9409917, 101 | US9409917, 102 | US9409917, 109 |...)
Show SMILES Clc1cccc2CCC(NC(=O)C3COc4ncccc34)c12
Show InChI InChI=1S/C17H15ClN2O2/c18-13-5-1-3-10-6-7-14(15(10)13)20-16(21)12-9-22-17-11(12)4-2-8-19-17/h1-5,8,12,14H,6-7,9H2,(H,20,21)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241754
PNG
(US9409917, 51)
Show SMILES OCc1cc(Cl)cc(Cl)c1CNC(=O)C1CCOc2ncccc12
Show InChI InChI=1S/C17H16Cl2N2O3/c18-11-6-10(9-22)14(15(19)7-11)8-21-16(23)12-3-5-24-17-13(12)2-1-4-20-17/h1-2,4,6-7,12,22H,3,5,8-9H2,(H,21,23)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241722
PNG
(US9409917, 19)
Show SMILES Clc1ccc(cn1)C1(CNC(=O)C2CCOc3ncccc23)CCCCC1
Show InChI InChI=1S/C21H24ClN3O2/c22-18-7-6-15(13-24-18)21(9-2-1-3-10-21)14-25-19(26)16-8-12-27-20-17(16)5-4-11-23-20/h4-7,11,13,16H,1-3,8-10,12,14H2,(H,25,26)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241770
PNG
(US9409917, 67)
Show SMILES FC1(F)CCC(CNC(=O)C2CCOc3ncccc23)(CC1)c1ccc(Cl)nc1
Show InChI InChI=1S/C21H22ClF2N3O2/c22-17-4-3-14(12-26-17)20(6-8-21(23,24)9-7-20)13-27-18(28)15-5-11-29-19-16(15)2-1-10-25-19/h1-4,10,12,15H,5-9,11,13H2,(H,27,28)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241814
PNG
(US9409917, 111 | US9409917, 112)
Show SMILES Clc1cccc2CCC[C@@H](NC(=O)C3COc4ncccc34)c12
Show InChI InChI=1S/C18H17ClN2O2/c19-14-7-1-4-11-5-2-8-15(16(11)14)21-17(22)13-10-23-18-12(13)6-3-9-20-18/h1,3-4,6-7,9,13,15H,2,5,8,10H2,(H,21,22)/t13?,15-/m1/s1
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241779
PNG
(US9409917, 104 | US9409917, 105 | US9409917, 76 | ...)
Show SMILES Clc1cc2CCC(NC(=O)C3COc4ncccc34)c2c(Cl)c1
Show InChI InChI=1S/C17H14Cl2N2O2/c18-10-6-9-3-4-14(15(9)13(19)7-10)21-16(22)12-8-23-17-11(12)2-1-5-20-17/h1-2,5-7,12,14H,3-4,8H2,(H,21,22)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241737
PNG
(US9409917, 34)
Show SMILES Clc1cccc(CNC(=O)C2CCOc3ncccc23)c1Cl
Show InChI InChI=1S/C16H14Cl2N2O2/c17-13-5-1-3-10(14(13)18)9-20-15(21)11-6-8-22-16-12(11)4-2-7-19-16/h1-5,7,11H,6,8-9H2,(H,20,21)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241804
PNG
(US9409917, 101 | US9409917, 102 | US9409917, 109 |...)
Show SMILES Clc1cccc2CCC(NC(=O)C3COc4ncccc34)c12
Show InChI InChI=1S/C17H15ClN2O2/c18-13-5-1-3-10-6-7-14(15(10)13)20-16(21)12-9-22-17-11(12)4-2-8-19-17/h1-5,8,12,14H,6-7,9H2,(H,20,21)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241796
PNG
(US9409917, 93)
Show SMILES OCCOCc1cc(Cl)cc(Cl)c1CNC(=O)C1COc2ncccc12
Show InChI InChI=1S/C18H18Cl2N2O4/c19-12-6-11(9-25-5-4-23)14(16(20)7-12)8-22-17(24)15-10-26-18-13(15)2-1-3-21-18/h1-3,6-7,15,23H,4-5,8-10H2,(H,22,24)
PDB

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n/an/a 11.4n/an/an/an/an/an/a



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241742
PNG
(US9409917, 39)
Show SMILES Clc1ccc(CNC(=O)C2CCOc3ncccc23)c(Cl)c1
Show InChI InChI=1S/C16H14Cl2N2O2/c17-11-4-3-10(14(18)8-11)9-20-15(21)12-5-7-22-16-13(12)2-1-6-19-16/h1-4,6,8,12H,5,7,9H2,(H,20,21)
PDB

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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241726
PNG
(US9409917, 23)
Show SMILES Clc1cc(Cl)c(CNC(=O)C2COc3ncccc23)c(C=C)c1
Show InChI InChI=1S/C17H14Cl2N2O2/c1-2-10-6-11(18)7-15(19)13(10)8-21-16(22)14-9-23-17-12(14)4-3-5-20-17/h2-7,14H,1,8-9H2,(H,21,22)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241817
PNG
(US9409917, 114)
Show SMILES Clc1cc(Cl)c(CNC(=O)C2COc3ncccc23)c(Cl)c1
Show InChI InChI=1S/C15H11Cl3N2O2/c16-8-4-12(17)10(13(18)5-8)6-20-14(21)11-7-22-15-9(11)2-1-3-19-15/h1-5,11H,6-7H2,(H,20,21)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241719
PNG
(US9409917, 16)
Show SMILES FC(F)(F)c1cccc(CNC(=O)C2COc3ncccc23)c1Cl
Show InChI InChI=1S/C16H12ClF3N2O2/c17-13-9(3-1-5-12(13)16(18,19)20)7-22-14(23)11-8-24-15-10(11)4-2-6-21-15/h1-6,11H,7-8H2,(H,22,23)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241724
PNG
(US9409917, 21)
Show SMILES Clc1cc(Cl)c(CNC(=O)C2COc3ncccc23)c(c1)C1CC1
Show InChI InChI=1S/C18H16Cl2N2O2/c19-11-6-13(10-3-4-10)14(16(20)7-11)8-22-17(23)15-9-24-18-12(15)2-1-5-21-18/h1-2,5-7,10,15H,3-4,8-9H2,(H,22,23)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241771
PNG
(US9409917, 68)
Show SMILES FC(F)(F)c1cc(Cl)cc(Cl)c1CNC(=O)C1COc2ncccc12
Show InChI InChI=1S/C16H11Cl2F3N2O2/c17-8-4-12(16(19,20)21)10(13(18)5-8)6-23-14(24)11-7-25-15-9(11)2-1-3-22-15/h1-5,11H,6-7H2,(H,23,24)
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US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241775
PNG
(US9409917, 72)
Show SMILES COCc1cc(Cl)cc(Cl)c1CNC(=O)C1COc2ncccc12
Show InChI InChI=1S/C17H16Cl2N2O3/c1-23-8-10-5-11(18)6-15(19)13(10)7-21-16(22)14-9-24-17-12(14)3-2-4-20-17/h2-6,14H,7-9H2,1H3,(H,21,22)
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US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241734
PNG
(US9409917, 31)
Show SMILES Cc1c(Cl)cccc1CNC(=O)C1CCOc2ncccc12
Show InChI InChI=1S/C17H17ClN2O2/c1-11-12(4-2-6-15(11)18)10-20-16(21)13-7-9-22-17-14(13)5-3-8-19-17/h2-6,8,13H,7,9-10H2,1H3,(H,20,21)
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US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241744
PNG
(US9409917, 41)
Show SMILES Cc1cc(Cl)cc(Cl)c1CNC(=O)C1CCOc2c1ccc[n+]2[O-]
Show InChI InChI=1S/C17H16Cl2N2O3/c1-10-7-11(18)8-15(19)14(10)9-20-16(22)12-4-6-24-17-13(12)3-2-5-21(17)23/h2-3,5,7-8,12H,4,6,9H2,1H3,(H,20,22)
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US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241706
PNG
(US9409917, 3 | US9409917, 4 | US9409917, 96 | US94...)
Show SMILES Cc1cc(Cl)cc(Cl)c1CNC(=O)C1COc2ncccc12
Show InChI InChI=1S/C16H14Cl2N2O2/c1-9-5-10(17)6-14(18)12(9)7-20-15(21)13-8-22-16-11(13)3-2-4-19-16/h2-6,13H,7-8H2,1H3,(H,20,21)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241706
PNG
(US9409917, 3 | US9409917, 4 | US9409917, 96 | US94...)
Show SMILES Cc1cc(Cl)cc(Cl)c1CNC(=O)C1COc2ncccc12
Show InChI InChI=1S/C16H14Cl2N2O2/c1-9-5-10(17)6-14(18)12(9)7-20-15(21)13-8-22-16-11(13)3-2-4-19-16/h2-6,13H,7-8H2,1H3,(H,20,21)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241776
PNG
(US9409917, 73)
Show SMILES FC(F)(F)c1c(Cl)cccc1CNC(=O)C1COc2ncccc12
Show InChI InChI=1S/C16H12ClF3N2O2/c17-12-5-1-3-9(13(12)16(18,19)20)7-22-14(23)11-8-24-15-10(11)4-2-6-21-15/h1-6,11H,7-8H2,(H,22,23)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241779
PNG
(US9409917, 104 | US9409917, 105 | US9409917, 76 | ...)
Show SMILES Clc1cc2CCC(NC(=O)C3COc4ncccc34)c2c(Cl)c1
Show InChI InChI=1S/C17H14Cl2N2O2/c18-10-6-9-3-4-14(15(9)13(19)7-10)21-16(22)12-8-23-17-11(12)2-1-5-20-17/h1-2,5-7,12,14H,3-4,8H2,(H,21,22)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241762
PNG
(US9409917, 59 | US9409917, 60 | US9409917, 81 | US...)
Show SMILES FC(F)(F)c1ncc(cn1)C(CNC(=O)C1COc2ncccc12)N1CCOCC1
Show InChI InChI=1S/C19H20F3N5O3/c20-19(21,22)18-25-8-12(9-26-18)15(27-4-6-29-7-5-27)10-24-16(28)14-11-30-17-13(14)2-1-3-23-17/h1-3,8-9,14-15H,4-7,10-11H2,(H,24,28)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241735
PNG
(US9409917, 32)
Show SMILES Fc1ccc(CNC(=O)C2CCOc3ncccc23)c(Cl)c1
Show InChI InChI=1S/C16H14ClFN2O2/c17-14-8-11(18)4-3-10(14)9-20-15(21)12-5-7-22-16-13(12)2-1-6-19-16/h1-4,6,8,12H,5,7,9H2,(H,20,21)
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US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241729
PNG
(US9409917, 26)
Show SMILES COc1cc(Cl)cc(Cl)c1CNC(=O)C1COc2ncccc12
Show InChI InChI=1S/C16H14Cl2N2O3/c1-22-14-6-9(17)5-13(18)11(14)7-20-15(21)12-8-23-16-10(12)3-2-4-19-16/h2-6,12H,7-8H2,1H3,(H,20,21)
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US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241757
PNG
(US9409917, 54)
Show SMILES O=C(NCC1(CCCCC1)c1ccccc1)C1CCOc2ncccc12
Show InChI InChI=1S/C22H26N2O2/c25-20(18-11-15-26-21-19(18)10-7-14-23-21)24-16-22(12-5-2-6-13-22)17-8-3-1-4-9-17/h1,3-4,7-10,14,18H,2,5-6,11-13,15-16H2,(H,24,25)
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US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241762
PNG
(US9409917, 59 | US9409917, 60 | US9409917, 81 | US...)
Show SMILES FC(F)(F)c1ncc(cn1)C(CNC(=O)C1COc2ncccc12)N1CCOCC1
Show InChI InChI=1S/C19H20F3N5O3/c20-19(21,22)18-25-8-12(9-26-18)15(27-4-6-29-7-5-27)10-24-16(28)14-11-30-17-13(14)2-1-3-23-17/h1-3,8-9,14-15H,4-7,10-11H2,(H,24,28)
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US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241777
PNG
(US9409917, 74 | US9409917, 75)
Show SMILES FC1(F)CCN(CC1)C(CNC(=O)C1COc2ncccc12)c1ccc(Cl)nc1
Show InChI InChI=1S/C20H21ClF2N4O2/c21-17-4-3-13(10-25-17)16(27-8-5-20(22,23)6-9-27)11-26-18(28)15-12-29-19-14(15)2-1-7-24-19/h1-4,7,10,15-16H,5-6,8-9,11-12H2,(H,26,28)
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US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241818
PNG
(US9409917, 115)
Show SMILES Cc1cc(Cl)cc(Cl)c1CNC(=O)C1COc2c1ccc[n+]2[O-]
Show InChI InChI=1S/C16H14Cl2N2O3/c1-9-5-10(17)6-14(18)12(9)7-19-15(21)13-8-23-16-11(13)3-2-4-20(16)22/h2-6,13H,7-8H2,1H3,(H,19,21)
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US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241816
PNG
(US9409917, 113)
Show SMILES Brc1cccc2CCC(NC(=O)C3COc4ncccc34)c12
Show InChI InChI=1S/C17H15BrN2O2/c18-13-5-1-3-10-6-7-14(15(10)13)20-16(21)12-9-22-17-11(12)4-2-8-19-17/h1-5,8,12,14H,6-7,9H2,(H,20,21)
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US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241773
PNG
(US9409917, 70 | US9409917, 71)
Show SMILES C[C@@H](NC(=O)C1COc2ncccc12)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C16H14Cl2N2O2/c1-9(11-5-4-10(17)7-14(11)18)20-15(21)13-8-22-16-12(13)3-2-6-19-16/h2-7,9,13H,8H2,1H3,(H,20,21)/t9-,13?/m1/s1
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US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241748
PNG
(US9409917, 45)
Show SMILES Clc1cccc(CNC(=O)C2COc3ncccc23)c1Cl
Show InChI InChI=1S/C15H12Cl2N2O2/c16-12-5-1-3-9(13(12)17)7-19-14(20)11-8-21-15-10(11)4-2-6-18-15/h1-6,11H,7-8H2,(H,19,20)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241727
PNG
(US9409917, 24 | US9409917, 25)
Show SMILES OCc1cc(Cl)cc(Cl)c1CNC(=O)C1COc2ncccc12
Show InChI InChI=1S/C16H14Cl2N2O3/c17-10-4-9(7-21)12(14(18)5-10)6-20-15(22)13-8-23-16-11(13)2-1-3-19-16/h1-5,13,21H,6-8H2,(H,20,22)
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US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241758
PNG
(US9409917, 55)
Show SMILES FC(F)(F)c1cccc(CNC(=O)C2(F)COc3ncccc23)c1Cl
Show InChI InChI=1S/C16H11ClF4N2O2/c17-12-9(3-1-4-10(12)16(19,20)21)7-23-14(24)15(18)8-25-13-11(15)5-2-6-22-13/h1-6H,7-8H2,(H,23,24)
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US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241765
PNG
(US9409917, 62)
Show SMILES FC(F)(F)c1ncc(cn1)C(CNC(=O)C1COc2ncccc12)N1CCC(F)(F)CC1
Show InChI InChI=1S/C20H20F5N5O2/c21-19(22)3-6-30(7-4-19)15(12-8-28-18(29-9-12)20(23,24)25)10-27-16(31)14-11-32-17-13(14)2-1-5-26-17/h1-2,5,8-9,14-15H,3-4,6-7,10-11H2,(H,27,31)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241745
PNG
(US9409917, 42)
Show SMILES Cc1c(Cl)cccc1CNC(=O)C1COc2ncccc12
Show InChI InChI=1S/C16H15ClN2O2/c1-10-11(4-2-6-14(10)17)8-19-15(20)13-9-21-16-12(13)5-3-7-18-16/h2-7,13H,8-9H2,1H3,(H,19,20)
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US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241782
PNG
(US9409917, 79 | US9409917, 80)
Show SMILES Clc1cc(Cl)c(CNC(=O)C2COc3ncccc23)c(Br)c1
Show InChI InChI=1S/C15H11BrCl2N2O2/c16-12-4-8(17)5-13(18)10(12)6-20-14(21)11-7-22-15-9(11)2-1-3-19-15/h1-5,11H,6-7H2,(H,20,21)
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US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241753
PNG
(US9409917, 50)
Show SMILES OCCOc1cc(Cl)cc(Cl)c1CNC(=O)C1COc2ncccc12
Show InChI InChI=1S/C17H16Cl2N2O4/c18-10-6-14(19)12(15(7-10)24-5-4-22)8-21-16(23)13-9-25-17-11(13)2-1-3-20-17/h1-3,6-7,13,22H,4-5,8-9H2,(H,21,23)
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US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241730
PNG
(US9409917, 27 | US9409917, 28)
Show SMILES Cc1ncc(cn1)C(CNC(=O)C1COc2ncccc12)N1CCC(F)(F)CC1
Show InChI InChI=1S/C20H23F2N5O2/c1-13-24-9-14(10-25-13)17(27-7-4-20(21,22)5-8-27)11-26-18(28)16-12-29-19-15(16)3-2-6-23-19/h2-3,6,9-10,16-17H,4-5,7-8,11-12H2,1H3,(H,26,28)
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US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241708
PNG
(US9409917, 5)
Show SMILES Clc1ccc(CNC(=O)C2COc3ncccc23)c(Cl)c1
Show InChI InChI=1S/C15H12Cl2N2O2/c16-10-4-3-9(13(17)6-10)7-19-14(20)12-8-21-15-11(12)2-1-5-18-15/h1-6,12H,7-8H2,(H,19,20)
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US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241802
PNG
(US9409917, 100 | US9409917, 99)
Show SMILES Clc1ccc2C(CCc2c1)NC(=O)C1COc2ncccc12
Show InChI InChI=1S/C17H15ClN2O2/c18-11-4-5-12-10(8-11)3-6-15(12)20-16(21)14-9-22-17-13(14)2-1-7-19-17/h1-2,4-5,7-8,14-15H,3,6,9H2,(H,20,21)
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US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241718
PNG
(US9409917, 15)
Show SMILES Fc1cc(Cl)cc(Cl)c1CNC(=O)C1COc2ncccc12
Show InChI InChI=1S/C15H11Cl2FN2O2/c16-8-4-12(17)10(13(18)5-8)6-20-14(21)11-7-22-15-9(11)2-1-3-19-15/h1-5,11H,6-7H2,(H,20,21)
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US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241741
PNG
(US9409917, 38)
Show SMILES Clc1ccc(CCNC(=O)C2CCOc3ncccc23)c(Cl)c1
Show InChI InChI=1S/C17H16Cl2N2O2/c18-12-4-3-11(15(19)10-12)5-8-20-16(22)13-6-9-23-17-14(13)2-1-7-21-17/h1-4,7,10,13H,5-6,8-9H2,(H,20,22)
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US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241723
PNG
(US9409917, 20)
Show SMILES FC1(COc2ncccc12)C(=O)NCc1cccc(Cl)c1Cl
Show InChI InChI=1S/C15H11Cl2FN2O2/c16-11-5-1-3-9(12(11)17)7-20-14(21)15(18)8-22-13-10(15)4-2-6-19-13/h1-6H,7-8H2,(H,20,21)
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US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241712
PNG
(US9409917, 9)
Show SMILES OC[C@@H](NC(=O)[C@H]1CCOc2ncccc12)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C17H16Cl2N2O3/c18-10-3-4-13(14(19)8-10)15(9-22)21-16(23)11-5-7-24-17-12(11)2-1-6-20-17/h1-4,6,8,11,15,22H,5,7,9H2,(H,21,23)/t11-,15+/m0/s1
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US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241806
PNG
(US9409917, 103)
Show SMILES FC(F)(F)c1ccc(CNC(=O)C2COc3ncccc23)c(Cl)c1
Show InChI InChI=1S/C16H12ClF3N2O2/c17-13-6-10(16(18,19)20)4-3-9(13)7-22-14(23)12-8-24-15-11(12)2-1-5-21-15/h1-6,12H,7-8H2,(H,22,23)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241795
PNG
(US9409917, 92)
Show SMILES FC(F)(F)c1ccc(cn1)C(CNC(=O)C1COc2ncccc12)N1CCOCC1
Show InChI InChI=1S/C20H21F3N4O3/c21-20(22,23)17-4-3-13(10-25-17)16(27-6-8-29-9-7-27)11-26-18(28)15-12-30-19-14(15)2-1-5-24-19/h1-5,10,15-16H,6-9,11-12H2,(H,26,28)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241746
PNG
(US9409917, 43)
Show SMILES Fc1ccc(CNC(=O)C2COc3ncccc23)c(Cl)c1
Show InChI InChI=1S/C15H12ClFN2O2/c16-13-6-10(17)4-3-9(13)7-19-14(20)12-8-21-15-11(12)2-1-5-18-15/h1-6,12H,7-8H2,(H,19,20)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241704
PNG
(US9409917, 1 | US9409917, 2)
Show SMILES OC[C@@H](NC(=O)C1COc2ncccc12)C1CCCCC1
Show InChI InChI=1S/C16H22N2O3/c19-9-14(11-5-2-1-3-6-11)18-15(20)13-10-21-16-12(13)7-4-8-17-16/h4,7-8,11,13-14,19H,1-3,5-6,9-10H2,(H,18,20)/t13?,14-/m1/s1
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241773
PNG
(US9409917, 70 | US9409917, 71)
Show SMILES C[C@@H](NC(=O)C1COc2ncccc12)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C16H14Cl2N2O2/c1-9(11-5-4-10(17)7-14(11)18)20-15(21)13-8-22-16-12(13)3-2-6-19-16/h2-7,9,13H,8H2,1H3,(H,20,21)/t9-,13?/m1/s1
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241709
PNG
(US9409917, 6 | US9409917, 7)
Show SMILES OC[C@@H](NC(=O)C1COc2ncccc12)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C16H14Cl2N2O3/c17-9-3-4-11(13(18)6-9)14(7-21)20-15(22)12-8-23-16-10(12)2-1-5-19-16/h1-6,12,14,21H,7-8H2,(H,20,22)/t12?,14-/m1/s1
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US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241716
PNG
(US9409917, 13 | US9409917, 14)
Show SMILES OCC(NC(=O)C1COc2ncccc12)C1CCCCCC1
Show InChI InChI=1S/C17H24N2O3/c20-10-15(12-6-3-1-2-4-7-12)19-16(21)14-11-22-17-13(14)8-5-9-18-17/h5,8-9,12,14-15,20H,1-4,6-7,10-11H2,(H,19,21)
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US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241777
PNG
(US9409917, 74 | US9409917, 75)
Show SMILES FC1(F)CCN(CC1)C(CNC(=O)C1COc2ncccc12)c1ccc(Cl)nc1
Show InChI InChI=1S/C20H21ClF2N4O2/c21-17-4-3-13(10-25-17)16(27-8-5-20(22,23)6-9-27)11-26-18(28)15-12-29-19-14(15)2-1-7-24-19/h1-4,7,10,15-16H,5-6,8-9,11-12H2,(H,26,28)
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US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241781
PNG
(US9409917, 78)
Show SMILES FC(F)(F)c1ccc(cc1)C(CNC(=O)C1COc2ncccc12)N1CCC(F)(F)CC1
Show InChI InChI=1S/C22H22F5N3O2/c23-21(24)7-10-30(11-8-21)18(14-3-5-15(6-4-14)22(25,26)27)12-29-19(31)17-13-32-20-16(17)2-1-9-28-20/h1-6,9,17-18H,7-8,10-13H2,(H,29,31)
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US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241762
PNG
(US9409917, 59 | US9409917, 60 | US9409917, 81 | US...)
Show SMILES FC(F)(F)c1ncc(cn1)C(CNC(=O)C1COc2ncccc12)N1CCOCC1
Show InChI InChI=1S/C19H20F3N5O3/c20-19(21,22)18-25-8-12(9-26-18)15(27-4-6-29-7-5-27)10-24-16(28)14-11-30-17-13(14)2-1-3-23-17/h1-3,8-9,14-15H,4-7,10-11H2,(H,24,28)
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US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241759
PNG
(US9409917, 56)
Show SMILES Clc1c(CNC(=O)C2COc3ncccc23)cccc1C#N
Show InChI InChI=1S/C16H12ClN3O2/c17-14-10(7-18)3-1-4-11(14)8-20-15(21)13-9-22-16-12(13)5-2-6-19-16/h1-6,13H,8-9H2,(H,20,21)
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US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241711
PNG
(US9409917, 8)
Show SMILES OC[C@@H](NC(=O)[C@H]1CCOc2ncccc12)C1CCCCC1
Show InChI InChI=1S/C17H24N2O3/c20-11-15(12-5-2-1-3-6-12)19-16(21)13-8-10-22-17-14(13)7-4-9-18-17/h4,7,9,12-13,15,20H,1-3,5-6,8,10-11H2,(H,19,21)/t13-,15+/m0/s1
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US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241752
PNG
(US9409917, 49)
Show SMILES Clc1ccc(CCNC(=O)C2COc3ncccc23)c(Cl)c1
Show InChI InChI=1S/C16H14Cl2N2O2/c17-11-4-3-10(14(18)8-11)5-7-19-15(21)13-9-22-16-12(13)2-1-6-20-16/h1-4,6,8,13H,5,7,9H2,(H,19,21)
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US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241779
PNG
(US9409917, 104 | US9409917, 105 | US9409917, 76 | ...)
Show SMILES Clc1cc2CCC(NC(=O)C3COc4ncccc34)c2c(Cl)c1
Show InChI InChI=1S/C17H14Cl2N2O2/c18-10-6-9-3-4-14(15(9)13(19)7-10)21-16(22)12-8-23-17-11(12)2-1-5-20-17/h1-2,5-7,12,14H,3-4,8H2,(H,21,22)
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ACTELION PHARMACEUTICALS LTD.

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Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241810
PNG
(US9409917, 107 | US9409917, 108)
Show SMILES O=C(N[C@@H]1CCCc2ccccc12)C1COc2ncccc12
Show InChI InChI=1S/C18H18N2O2/c21-17(15-11-22-18-14(15)8-4-10-19-18)20-16-9-3-6-12-5-1-2-7-13(12)16/h1-2,4-5,7-8,10,15-16H,3,6,9,11H2,(H,20,21)/t15?,16-/m1/s1
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Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241804
PNG
(US9409917, 101 | US9409917, 102 | US9409917, 109 |...)
Show SMILES Clc1cccc2CCC(NC(=O)C3COc4ncccc34)c12
Show InChI InChI=1S/C17H15ClN2O2/c18-13-5-1-3-10-6-7-14(15(10)13)20-16(21)12-9-22-17-11(12)4-2-8-19-17/h1-5,8,12,14H,6-7,9H2,(H,20,21)
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Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241794
PNG
(US9409917, 91)
Show SMILES O=C(NCC(N1CCOCC1)c1cnc(nc1)C1CC1)C1COc2ncccc12
Show InChI InChI=1S/C21H25N5O3/c27-20(17-13-29-21-16(17)2-1-5-22-21)25-12-18(26-6-8-28-9-7-26)15-10-23-19(24-11-15)14-3-4-14/h1-2,5,10-11,14,17-18H,3-4,6-9,12-13H2,(H,25,27)
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Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241814
PNG
(US9409917, 111 | US9409917, 112)
Show SMILES Clc1cccc2CCC[C@@H](NC(=O)C3COc4ncccc34)c12
Show InChI InChI=1S/C18H17ClN2O2/c19-14-7-1-4-11-5-2-8-15(16(11)14)21-17(22)13-10-23-18-12(13)6-3-9-20-18/h1,3-4,6-7,9,13,15H,2,5,8,10H2,(H,21,22)/t13?,15-/m1/s1
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Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241732
PNG
(US9409917, 29 | US9409917, 30)
Show SMILES Cc1ncc(cn1)C(CNC(=O)C1COc2ncccc12)N1CCOCC1
Show InChI InChI=1S/C19H23N5O3/c1-13-21-9-14(10-22-13)17(24-5-7-26-8-6-24)11-23-18(25)16-12-27-19-15(16)3-2-4-20-19/h2-4,9-10,16-17H,5-8,11-12H2,1H3,(H,23,25)
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Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241736
PNG
(US9409917, 33)
Show SMILES O=C(NCc1ccc(Oc2ccccc2)cc1)C1CCOc2ncccc12
Show InChI InChI=1S/C22H20N2O3/c25-21(19-12-14-26-22-20(19)7-4-13-23-22)24-15-16-8-10-18(11-9-16)27-17-5-2-1-3-6-17/h1-11,13,19H,12,14-15H2,(H,24,25)
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Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241755
PNG
(US9409917, 52)
Show SMILES OCC(NC(=O)C1CCOc2ncccc12)C1CCCCCC1
Show InChI InChI=1S/C18H26N2O3/c21-12-16(13-6-3-1-2-4-7-13)20-17(22)14-9-11-23-18-15(14)8-5-10-19-18/h5,8,10,13-14,16,21H,1-4,6-7,9,11-12H2,(H,20,22)
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Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241802
PNG
(US9409917, 100 | US9409917, 99)
Show SMILES Clc1ccc2C(CCc2c1)NC(=O)C1COc2ncccc12
Show InChI InChI=1S/C17H15ClN2O2/c18-11-4-5-12-10(8-11)3-6-15(12)20-16(21)14-9-22-17-13(14)2-1-7-19-17/h1-2,4-5,7-8,14-15H,3,6,9H2,(H,20,21)
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Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241821
PNG
(US9409917, 118)
Show SMILES OCc1cccc(Cl)c1CNC(=O)C1COc2ncccc12
Show InChI InChI=1S/C16H15ClN2O3/c17-14-5-1-3-10(8-20)12(14)7-19-15(21)13-9-22-16-11(13)4-2-6-18-16/h1-6,13,20H,7-9H2,(H,19,21)
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Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241739
PNG
(US9409917, 36)
Show SMILES FC(F)(F)c1ccc(CNC(=O)C2CCOc3ncccc23)cc1
Show InChI InChI=1S/C17H15F3N2O2/c18-17(19,20)12-5-3-11(4-6-12)10-22-15(23)13-7-9-24-16-14(13)2-1-8-21-16/h1-6,8,13H,7,9-10H2,(H,22,23)
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Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241809
PNG
(US9409917, 106)
Show SMILES Clc1ccc(CCCNC(=O)C2COc3ncccc23)c(Cl)c1
Show InChI InChI=1S/C17H16Cl2N2O2/c18-12-6-5-11(15(19)9-12)3-1-7-20-16(22)14-10-23-17-13(14)4-2-8-21-17/h2,4-6,8-9,14H,1,3,7,10H2,(H,20,22)
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Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241762
PNG
(US9409917, 59 | US9409917, 60 | US9409917, 81 | US...)
Show SMILES FC(F)(F)c1ncc(cn1)C(CNC(=O)C1COc2ncccc12)N1CCOCC1
Show InChI InChI=1S/C19H20F3N5O3/c20-19(21,22)18-25-8-12(9-26-18)15(27-4-6-29-7-5-27)10-24-16(28)14-11-30-17-13(14)2-1-3-23-17/h1-3,8-9,14-15H,4-7,10-11H2,(H,24,28)
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ACTELION PHARMACEUTICALS LTD.

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Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241764
PNG
(US9409917, 61)
Show SMILES Clc1cc(ccc1CNC(=O)C1COc2ncccc12)C#N
Show InChI InChI=1S/C16H12ClN3O2/c17-14-6-10(7-18)3-4-11(14)8-20-15(21)13-9-22-16-12(13)2-1-5-19-16/h1-6,13H,8-9H2,(H,20,21)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241772
PNG
(US9409917, 69)
Show SMILES O=C(N[C@@H]1CCc2ccccc12)[C@@H]1COc2ncccc12
Show InChI InChI=1S/C17H16N2O2/c20-16(14-10-21-17-13(14)6-3-9-18-17)19-15-8-7-11-4-1-2-5-12(11)15/h1-6,9,14-15H,7-8,10H2,(H,19,20)/t14-,15-/m1/s1
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ACTELION PHARMACEUTICALS LTD.

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Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241738
PNG
(US9409917, 35)
Show SMILES Clc1ccc(CNC(=O)C2CCOc3ncccc23)cc1
Show InChI InChI=1S/C16H15ClN2O2/c17-12-5-3-11(4-6-12)10-19-15(20)13-7-9-21-16-14(13)2-1-8-18-16/h1-6,8,13H,7,9-10H2,(H,19,20)
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ACTELION PHARMACEUTICALS LTD.

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Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241797
PNG
(US9409917, 94 | US9409917, 95)
Show SMILES Clc1cc2C(CCc2c(Cl)c1)NC(=O)C1COc2ncccc12
Show InChI InChI=1S/C17H14Cl2N2O2/c18-9-6-12-10(14(19)7-9)3-4-15(12)21-16(22)13-8-23-17-11(13)2-1-5-20-17/h1-2,5-7,13,15H,3-4,8H2,(H,21,22)
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Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241709
PNG
(US9409917, 6 | US9409917, 7)
Show SMILES OC[C@@H](NC(=O)C1COc2ncccc12)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C16H14Cl2N2O3/c17-9-3-4-11(13(18)6-9)14(7-21)20-15(22)12-8-23-16-10(12)2-1-5-19-16/h1-6,12,14,21H,7-8H2,(H,20,22)/t12?,14-/m1/s1
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Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241740
PNG
(US9409917, 37)
Show SMILES CN(Cc1ccc(Cl)cc1)C(=O)C1CCOc2ncccc12
Show InChI InChI=1S/C17H17ClN2O2/c1-20(11-12-4-6-13(18)7-5-12)17(21)15-8-10-22-16-14(15)3-2-9-19-16/h2-7,9,15H,8,10-11H2,1H3
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US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241749
PNG
(US9409917, 46)
Show SMILES Clc1ccc(CNC(=O)C2COc3ncccc23)cc1
Show InChI InChI=1S/C15H13ClN2O2/c16-11-5-3-10(4-6-11)8-18-14(19)13-9-20-15-12(13)2-1-7-17-15/h1-7,13H,8-9H2,(H,18,19)
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Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241716
PNG
(US9409917, 13 | US9409917, 14)
Show SMILES OCC(NC(=O)C1COc2ncccc12)C1CCCCCC1
Show InChI InChI=1S/C17H24N2O3/c20-10-15(12-6-3-1-2-4-7-12)19-16(21)14-11-22-17-13(14)8-5-9-18-17/h5,8-9,12,14-15,20H,1-4,6-7,10-11H2,(H,19,21)
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Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241797
PNG
(US9409917, 94 | US9409917, 95)
Show SMILES Clc1cc2C(CCc2c(Cl)c1)NC(=O)C1COc2ncccc12
Show InChI InChI=1S/C17H14Cl2N2O2/c18-9-6-12-10(14(19)7-9)3-4-15(12)21-16(22)13-8-23-17-11(13)2-1-5-20-17/h1-2,5-7,13,15H,3-4,8H2,(H,21,22)
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Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241790
PNG
(US9409917, 87)
Show SMILES COc1ccc(cn1)C(CNC(=O)C1COc2ncccc12)N1CCOCC1
Show InChI InChI=1S/C20H24N4O4/c1-26-18-5-4-14(11-22-18)17(24-7-9-27-10-8-24)12-23-19(25)16-13-28-20-15(16)3-2-6-21-20/h2-6,11,16-17H,7-10,12-13H2,1H3,(H,23,25)
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Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241704
PNG
(US9409917, 1 | US9409917, 2)
Show SMILES OC[C@@H](NC(=O)C1COc2ncccc12)C1CCCCC1
Show InChI InChI=1S/C16H22N2O3/c19-9-14(11-5-2-1-3-6-11)18-15(20)13-10-21-16-12(13)7-4-8-17-16/h4,7-8,11,13-14,19H,1-3,5-6,9-10H2,(H,18,20)/t13?,14-/m1/s1
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241751
PNG
(US9409917, 48)
Show SMILES CN(Cc1ccc(Cl)cc1)C(=O)C1COc2ncccc12
Show InChI InChI=1S/C16H15ClN2O2/c1-19(9-11-4-6-12(17)7-5-11)16(20)14-10-21-15-13(14)3-2-8-18-15/h2-8,14H,9-10H2,1H3
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241747
PNG
(US9409917, 44)
Show SMILES O=C(NCc1ccc(Oc2ccccc2)cc1)C1COc2ncccc12
Show InChI InChI=1S/C21H18N2O3/c24-20(19-14-25-21-18(19)7-4-12-22-21)23-13-15-8-10-17(11-9-15)26-16-5-2-1-3-6-16/h1-12,19H,13-14H2,(H,23,24)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241793
PNG
(US9409917, 90)
Show SMILES Cc1ccc(cn1)C(CNC(=O)C1COc2ncccc12)N1CCOCC1
Show InChI InChI=1S/C20H24N4O3/c1-14-4-5-15(11-22-14)18(24-7-9-26-10-8-24)12-23-19(25)17-13-27-20-16(17)3-2-6-21-20/h2-6,11,17-18H,7-10,12-13H2,1H3,(H,23,25)
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n/an/a 1.15E+3n/an/an/an/an/an/a



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241756
PNG
(US9409917, 53)
Show SMILES Fc1cc(CNC(=O)C2CCOc3ncccc23)ccc1OC(F)(F)F
Show InChI InChI=1S/C17H14F4N2O3/c18-13-8-10(3-4-14(13)26-17(19,20)21)9-23-15(24)11-5-7-25-16-12(11)2-1-6-22-16/h1-4,6,8,11H,5,7,9H2,(H,23,24)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241810
PNG
(US9409917, 107 | US9409917, 108)
Show SMILES O=C(N[C@@H]1CCCc2ccccc12)C1COc2ncccc12
Show InChI InChI=1S/C18H18N2O2/c21-17(15-11-22-18-14(15)8-4-10-19-18)20-16-9-3-6-12-5-1-2-7-13(12)16/h1-2,4-5,7-8,10,15-16H,3,6,9,11H2,(H,20,21)/t15?,16-/m1/s1
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241750
PNG
(US9409917, 47)
Show SMILES FC(F)(F)c1ccc(CNC(=O)C2COc3ncccc23)cc1
Show InChI InChI=1S/C16H13F3N2O2/c17-16(18,19)11-5-3-10(4-6-11)8-21-14(22)13-9-23-15-12(13)2-1-7-20-15/h1-7,13H,8-9H2,(H,21,22)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241730
PNG
(US9409917, 27 | US9409917, 28)
Show SMILES Cc1ncc(cn1)C(CNC(=O)C1COc2ncccc12)N1CCC(F)(F)CC1
Show InChI InChI=1S/C20H23F2N5O2/c1-13-24-9-14(10-25-13)17(27-7-4-20(21,22)5-8-27)11-26-18(28)16-12-29-19-15(16)3-2-6-23-19/h2-3,6,9-10,16-17H,4-5,7-8,11-12H2,1H3,(H,26,28)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241791
PNG
(US9409917, 88 | US9409917, 89)
Show SMILES O=C(NC1CC(=O)c2ccccc12)C1COc2ncccc12
Show InChI InChI=1S/C17H14N2O3/c20-15-8-14(10-4-1-2-5-11(10)15)19-16(21)13-9-22-17-12(13)6-3-7-18-17/h1-7,13-14H,8-9H2,(H,19,21)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241820
PNG
(US9409917, 117)
Show SMILES OCc1cc(Cl)ccc1CNC(=O)C1COc2ncccc12
Show InChI InChI=1S/C16H15ClN2O3/c17-12-4-3-10(11(6-12)8-20)7-19-15(21)14-9-22-16-13(14)2-1-5-18-16/h1-6,14,20H,7-9H2,(H,19,21)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241732
PNG
(US9409917, 29 | US9409917, 30)
Show SMILES Cc1ncc(cn1)C(CNC(=O)C1COc2ncccc12)N1CCOCC1
Show InChI InChI=1S/C19H23N5O3/c1-13-21-9-14(10-22-13)17(24-5-7-26-8-6-24)11-23-18(25)16-12-27-19-15(16)3-2-4-20-19/h2-4,9-10,16-17H,5-8,11-12H2,1H3,(H,23,25)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241762
PNG
(US9409917, 59 | US9409917, 60 | US9409917, 81 | US...)
Show SMILES FC(F)(F)c1ncc(cn1)C(CNC(=O)C1COc2ncccc12)N1CCOCC1
Show InChI InChI=1S/C19H20F3N5O3/c20-19(21,22)18-25-8-12(9-26-18)15(27-4-6-29-7-5-27)10-24-16(28)14-11-30-17-13(14)2-1-3-23-17/h1-3,8-9,14-15H,4-7,10-11H2,(H,24,28)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241791
PNG
(US9409917, 88 | US9409917, 89)
Show SMILES O=C(NC1CC(=O)c2ccccc12)C1COc2ncccc12
Show InChI InChI=1S/C17H14N2O3/c20-15-8-14(10-4-1-2-5-11(10)15)19-16(21)13-9-22-17-12(13)6-3-7-18-17/h1-7,13-14H,8-9H2,(H,19,21)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241761
PNG
(US9409917, 58)
Show SMILES Clc1ccc(c(Cl)c1)C1(CC1)NC(=O)C1CCOc2ncccc12
Show InChI InChI=1S/C18H16Cl2N2O2/c19-11-3-4-14(15(20)10-11)18(6-7-18)22-16(23)12-5-9-24-17-13(12)2-1-8-21-17/h1-4,8,10,12H,5-7,9H2,(H,22,23)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241760
PNG
(US9409917, 57)
Show SMILES Fc1cc(CNC(=O)C2COc3ncccc23)ccc1OC(F)(F)F
Show InChI InChI=1S/C16H12F4N2O3/c17-12-6-9(3-4-13(12)25-16(18,19)20)7-22-14(23)11-8-24-15-10(11)2-1-5-21-15/h1-6,11H,7-8H2,(H,22,23)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241713
PNG
(US9409917, 10)
Show SMILES OC1(CNC(=O)C2CCOc3ncccc23)CCCCC1
Show InChI InChI=1S/C16H22N2O3/c19-14(18-11-16(20)7-2-1-3-8-16)12-6-10-21-15-13(12)5-4-9-17-15/h4-5,9,12,20H,1-3,6-8,10-11H2,(H,18,19)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241768
PNG
(US9409917, 65)
Show SMILES O[C@@H]1Cc2ccccc2[C@@H]1NC(=O)[C@@H]1COc2ncccc12
Show InChI InChI=1S/C17H16N2O3/c20-14-8-10-4-1-2-5-11(10)15(14)19-16(21)13-9-22-17-12(13)6-3-7-18-17/h1-7,13-15,20H,8-9H2,(H,19,21)/t13-,14-,15+/m1/s1
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241766
PNG
(US9409917, 63)
Show SMILES NC(=O)C1(CCCC1)NC(=O)C1COc2ncccc12
Show InChI InChI=1S/C14H17N3O3/c15-13(19)14(5-1-2-6-14)17-11(18)10-8-20-12-9(10)4-3-7-16-12/h3-4,7,10H,1-2,5-6,8H2,(H2,15,19)(H,17,18)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241767
PNG
(US9409917, 64)
Show SMILES O=C(NC1CC1c1ccccc1)C1COc2ncccc12
Show InChI InChI=1S/C17H16N2O2/c20-16(14-10-21-17-12(14)7-4-8-18-17)19-15-9-13(15)11-5-2-1-3-6-11/h1-8,13-15H,9-10H2,(H,19,20)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241779
PNG
(US9409917, 104 | US9409917, 105 | US9409917, 76 | ...)
Show SMILES Clc1cc2CCC(NC(=O)C3COc4ncccc34)c2c(Cl)c1
Show InChI InChI=1S/C17H14Cl2N2O2/c18-10-6-9-3-4-14(15(9)13(19)7-10)21-16(22)12-8-23-17-11(12)2-1-5-20-17/h1-2,5-7,12,14H,3-4,8H2,(H,21,22)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241769
PNG
(US9409917, 66)
Show SMILES NC(=O)C1CCCCC1NC(=O)C1COc2ncccc12
Show InChI InChI=1S/C15H19N3O3/c16-13(19)10-4-1-2-6-12(10)18-14(20)11-8-21-15-9(11)5-3-7-17-15/h3,5,7,10-12H,1-2,4,6,8H2,(H2,16,19)(H,18,20)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241762
PNG
(US9409917, 59 | US9409917, 60 | US9409917, 81 | US...)
Show SMILES FC(F)(F)c1ncc(cn1)C(CNC(=O)C1COc2ncccc12)N1CCOCC1
Show InChI InChI=1S/C19H20F3N5O3/c20-19(21,22)18-25-8-12(9-26-18)15(27-4-6-29-7-5-27)10-24-16(28)14-11-30-17-13(14)2-1-3-23-17/h1-3,8-9,14-15H,4-7,10-11H2,(H,24,28)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241819
PNG
(US9409917, 116)
Show SMILES Clc1cc2CC(NC(=O)C3COc4ncccc34)C(=O)c2c(Cl)c1
Show InChI InChI=1S/C17H12Cl2N2O3/c18-9-4-8-5-13(15(22)14(8)12(19)6-9)21-16(23)11-7-24-17-10(11)2-1-3-20-17/h1-4,6,11,13H,5,7H2,(H,21,23)
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n/an/a 9.01E+3n/an/an/an/an/an/a



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM241804
PNG
(US9409917, 101 | US9409917, 102 | US9409917, 109 |...)
Show SMILES Clc1cccc2CCC(NC(=O)C3COc4ncccc34)c12
Show InChI InChI=1S/C17H15ClN2O2/c18-13-5-1-3-10-6-7-14(15(10)13)20-16(21)12-9-22-17-11(12)4-2-8-19-17/h1-5,8,12,14H,6-7,9H2,(H,20,21)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
HEK cells stably expressing P2X7 were used to screen drugs using the YO-PRO1 assay. Cells were grown to confluency in adherent culture at 37° C. ...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%