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Patent code US9416132

Compile Data Set for Download or QSAR
Found 120 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242374
PNG
(US10047093, 8-31 | US9416132, 8-31)
Show SMILES CC(C)(O)[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(c3)C(F)(F)F)n2n1
Show InChI InChI=1S/C22H25F3N4O/c1-21(2,30)15-6-8-17(9-7-15)27-19-10-11-20-26-13-18(29(20)28-19)14-4-3-5-16(12-14)22(23,24)25/h3-5,10-13,15,17,30H,6-9H2,1-2H3,(H,27,28)/t15-,17-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242397
PNG
(US10047093, 8-79 | US9416132, 8-79)
Show SMILES CC(C)(N)[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(Cl)c3)n2n1
Show InChI InChI=1S/C21H26ClN5/c1-21(2,23)15-6-8-17(9-7-15)25-19-10-11-20-24-13-18(27(20)26-19)14-4-3-5-16(22)12-14/h3-5,10-13,15,17H,6-9,23H2,1-2H3,(H,25,26)/t15-,17-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242380
PNG
(US10047093, 8-37 | US9416132, 8-37)
Show SMILES CC(C)(O)[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(Cl)c3)n2n1
Show InChI InChI=1S/C21H25ClN4O/c1-21(2,27)15-6-8-17(9-7-15)24-19-10-11-20-23-13-18(26(20)25-19)14-4-3-5-16(22)12-14/h3-5,10-13,15,17,27H,6-9H2,1-2H3,(H,24,25)/t15-,17-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242352
PNG
(US10047093, 8-8 | US9416132, 8-8)
Show SMILES N[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(OC(F)(F)F)c3)n2n1
Show InChI InChI=1S/C19H20F3N5O/c20-19(21,22)28-15-3-1-2-12(10-15)16-11-24-18-9-8-17(26-27(16)18)25-14-6-4-13(23)5-7-14/h1-3,8-11,13-14H,4-7,23H2,(H,25,26)/t13-,14-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242388
PNG
(US10047093, 8-68 | US9416132, 8-68)
Show SMILES N[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(Cl)c3)n2n1
Show InChI InChI=1S/C18H20ClN5/c19-13-3-1-2-12(10-13)16-11-21-18-9-8-17(23-24(16)18)22-15-6-4-14(20)5-7-15/h1-3,8-11,14-15H,4-7,20H2,(H,22,23)/t14-,15-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242372
PNG
(US10047093, 8-29 | US9416132, 8-29)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(c3)C(F)(F)F)n2n1
Show InChI InChI=1S/C19H19F3N4O/c20-19(21,22)13-3-1-2-12(10-13)16-11-23-18-9-8-17(25-26(16)18)24-14-4-6-15(27)7-5-14/h1-3,8-11,14-15,27H,4-7H2,(H,24,25)/t14-,15-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM50043692
PNG
(CHEMBL3355542 | US10047093, 8-52 | US9416132, 8-52)
Show SMILES N[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(OC(F)(F)F)c3)c2n1
Show InChI InChI=1S/C19H20F3N5O/c20-19(21,22)28-15-3-1-2-12(10-15)16-11-24-27-9-8-17(26-18(16)27)25-14-6-4-13(23)5-7-14/h1-3,8-11,13-14H,4-7,23H2,(H,25,26)/t13-,14-
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US Patent
n/an/a 5n/an/an/an/an/an/a



Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242348
PNG
(US10047093, 8-4 | US9416132, 8-4)
Show SMILES O[C@H]1CC[C@@H](CC1)Oc1ccc2ncc(-c3cccc(OC(F)(F)F)c3)n2n1
Show InChI InChI=1S/C19H18F3N3O3/c20-19(21,22)28-15-3-1-2-12(10-15)16-11-23-17-8-9-18(24-25(16)17)27-14-6-4-13(26)5-7-14/h1-3,8-11,13-14,26H,4-7H2/t13-,14-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242378
PNG
(US10047093, 8-35 | US9416132, 8-35)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(Cl)c3)n2n1
Show InChI InChI=1S/C18H19ClN4O/c19-13-3-1-2-12(10-13)16-11-20-18-9-8-17(22-23(16)18)21-14-4-6-15(24)7-5-14/h1-3,8-11,14-15,24H,4-7H2,(H,21,22)/t14-,15-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242355
PNG
(US9416132, 8-11)
Show SMILES CO[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(OC(F)(F)F)c3)n2n1
Show InChI InChI=1S/C20H21F3N4O2/c1-28-15-7-5-14(6-8-15)25-18-9-10-19-24-12-17(27(19)26-18)13-3-2-4-16(11-13)29-20(21,22)23/h2-4,9-12,14-15H,5-8H2,1H3,(H,25,26)/t14-,15-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242389
PNG
(US9416132, 8-70)
Show SMILES NC1CCCC(C1)Nc1ccc2ncc(-c3cccc(Cl)c3)n2n1
Show InChI InChI=1S/C18H20ClN5/c19-13-4-1-3-12(9-13)16-11-21-18-8-7-17(23-24(16)18)22-15-6-2-5-14(20)10-15/h1,3-4,7-9,11,14-15H,2,5-6,10,20H2,(H,22,23)
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242354
PNG
(US10047093, 8-10 | US9416132, 8-10)
Show SMILES CC(C)(O)[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(OC(F)(F)F)c3)n2n1
Show InChI InChI=1S/C22H25F3N4O2/c1-21(2,30)15-6-8-16(9-7-15)27-19-10-11-20-26-13-18(29(20)28-19)14-4-3-5-17(12-14)31-22(23,24)25/h3-5,10-13,15-16,30H,6-9H2,1-2H3,(H,27,28)/t15-,16-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242351
PNG
(US10047093, 8-7 | US9416132, 8-7)
Show SMILES O[C@H]1C[C@H](CNc2ccc3ncc(-c4cccc(OC(F)(F)F)c4)n3n2)C1
Show InChI InChI=1S/C18H17F3N4O2/c19-18(20,21)27-14-3-1-2-12(8-14)15-10-23-17-5-4-16(24-25(15)17)22-9-11-6-13(26)7-11/h1-5,8,10-11,13,26H,6-7,9H2,(H,22,24)/t11-,13-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242390
PNG
(US10047093, 8-71 | US9416132, 8-71)
Show SMILES NC1CCCN(C1)c1ccc2ncc(-c3cccc(Cl)c3)n2n1
Show InChI InChI=1S/C17H18ClN5/c18-13-4-1-3-12(9-13)15-10-20-16-6-7-17(21-23(15)16)22-8-2-5-14(19)11-22/h1,3-4,6-7,9-10,14H,2,5,8,11,19H2
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242353
PNG
(US10047093, 8-9 | US9416132, 8-9)
Show SMILES C[C@]1(O)CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(OC(F)(F)F)c3)n2n1
Show InChI InChI=1S/C20H21F3N4O2/c1-19(28)9-7-14(8-10-19)25-17-5-6-18-24-12-16(27(18)26-17)13-3-2-4-15(11-13)29-20(21,22)23/h2-6,11-12,14,28H,7-10H2,1H3,(H,25,26)/t14-,19-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242362
PNG
(US10047093, 8-19 | US9416132, 8-19)
Show SMILES FC(F)(F)Oc1cccc(c1)-c1cnc2ccc(NCC3CCOCC3)nn12
Show InChI InChI=1S/C19H19F3N4O2/c20-19(21,22)28-15-3-1-2-14(10-15)16-12-24-18-5-4-17(25-26(16)18)23-11-13-6-8-27-9-7-13/h1-5,10,12-13H,6-9,11H2,(H,23,25)
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242345
PNG
(US10047093, 8-1 | US9416132, 8-1)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(OC(F)(F)F)c3)n2n1
Show InChI InChI=1S/C19H19F3N4O2/c20-19(21,22)28-15-3-1-2-12(10-15)16-11-23-18-9-8-17(25-26(16)18)24-13-4-6-14(27)7-5-13/h1-3,8-11,13-14,27H,4-7H2,(H,24,25)/t13-,14-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242403
PNG
(US9416132, 8-86)
Show SMILES FC(F)(F)Oc1cccc(c1)-c1cnc2ccc(N[C@H]3CC[C@@H](CC3)C#N)nn12
Show InChI InChI=1S/C20H18F3N5O/c21-20(22,23)29-16-3-1-2-14(10-16)17-12-25-19-9-8-18(27-28(17)19)26-15-6-4-13(11-24)5-7-15/h1-3,8-10,12-13,15H,4-7H2,(H,26,27)/t13-,15-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242395
PNG
(US10047093, 8-77 | US9416132, 8-77)
Show SMILES CC(C)(O)[C@H]1CC[C@@H](CC1)Oc1ccc2ncc(-c3cccc(Cl)c3)n2n1
Show InChI InChI=1S/C21H24ClN3O2/c1-21(2,26)15-6-8-17(9-7-15)27-20-11-10-19-23-13-18(25(19)24-20)14-4-3-5-16(22)12-14/h3-5,10-13,15,17,26H,6-9H2,1-2H3/t15-,17-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242387
PNG
(US10047093, 8-45 | US9416132, 8-45)
Show SMILES CN(C)CC(=O)N1CCC(CNc2ccc3ncc(-c4cccc(OC(F)(F)F)c4)n3n2)CC1
Show InChI InChI=1S/C23H27F3N6O2/c1-30(2)15-22(33)31-10-8-16(9-11-31)13-27-20-6-7-21-28-14-19(32(21)29-20)17-4-3-5-18(12-17)34-23(24,25)26/h3-7,12,14,16H,8-11,13,15H2,1-2H3,(H,27,29)
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242363
PNG
(US10047093, 8-20 | US9416132, 8-20)
Show SMILES CC(C)(O)C(=O)N1CCC(CNc2ccc3ncc(-c4cccc(OC(F)(F)F)c4)n3n2)CC1
Show InChI InChI=1S/C23H26F3N5O3/c1-22(2,33)21(32)30-10-8-15(9-11-30)13-27-19-6-7-20-28-14-18(31(20)29-19)16-4-3-5-17(12-16)34-23(24,25)26/h3-7,12,14-15,33H,8-11,13H2,1-2H3,(H,27,29)
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242392
PNG
(US9416132, 8-73)
Show SMILES Clc1cccc(c1)-c1cnc2ccc(N[C@H]3CC[C@@H](CC3)C#N)nn12
Show InChI InChI=1S/C19H18ClN5/c20-15-3-1-2-14(10-15)17-12-22-19-9-8-18(24-25(17)19)23-16-6-4-13(11-21)5-7-16/h1-3,8-10,12-13,16H,4-7H2,(H,23,24)/t13-,16-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM50043662
PNG
(CHEMBL3355552 | US10047093, 8-56 | US9416132, 8-56)
Show SMILES CC(C)(O)[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(c3)C(F)(F)F)c2n1
Show InChI InChI=1S/C22H25F3N4O/c1-21(2,30)15-6-8-17(9-7-15)27-19-10-11-29-20(28-19)18(13-26-29)14-4-3-5-16(12-14)22(23,24)25/h3-5,10-13,15,17,30H,6-9H2,1-2H3,(H,27,28)/t15-,17-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242346
PNG
(US10047093, 8-2 | US9416132, 8-2)
Show SMILES O[C@H]1CC[C@H](CC1)Nc1ccc2ncc(-c3cccc(OC(F)(F)F)c3)n2n1
Show InChI InChI=1S/C19H19F3N4O2/c20-19(21,22)28-15-3-1-2-12(10-15)16-11-23-18-9-8-17(25-26(16)18)24-13-4-6-14(27)7-5-13/h1-3,8-11,13-14,27H,4-7H2,(H,24,25)/t13-,14+
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242381
PNG
(US9416132, 8-38)
Show SMILES CO[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(Cl)c3)n2n1
Show InChI InChI=1S/C19H21ClN4O/c1-25-16-7-5-15(6-8-16)22-18-9-10-19-21-12-17(24(19)23-18)13-3-2-4-14(20)11-13/h2-4,9-12,15-16H,5-8H2,1H3,(H,22,23)/t15-,16-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242402
PNG
(US9416132, 8-85)
Show SMILES FC(F)(F)c1cccc(c1)-c1cnc2ccc(N[C@H]3CC[C@@H](CC3)C#N)nn12
Show InChI InChI=1S/C20H18F3N5/c21-20(22,23)15-3-1-2-14(10-15)17-12-25-19-9-8-18(27-28(17)19)26-16-6-4-13(11-24)5-7-16/h1-3,8-10,12-13,16H,4-7H2,(H,26,27)/t13-,16-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242370
PNG
(US10047093, 8-27 | US9416132, 8-27)
Show SMILES OCCN1CCC(CNc2ccc3ncc(-c4cccc(OC(F)(F)F)c4)n3n2)CC1
Show InChI InChI=1S/C21H24F3N5O2/c22-21(23,24)31-17-3-1-2-16(12-17)18-14-26-20-5-4-19(27-29(18)20)25-13-15-6-8-28(9-7-15)10-11-30/h1-5,12,14-15,30H,6-11,13H2,(H,25,27)
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM50043697
PNG
(CHEMBL3355987 | US10047093, 8-63 | US9416132, 8-63)
Show SMILES CC(C)(O)[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(Cl)c3)c2n1
Show InChI InChI=1S/C21H25ClN4O/c1-21(2,27)15-6-8-17(9-7-15)24-19-10-11-26-20(25-19)18(13-23-26)14-4-3-5-16(22)12-14/h3-5,10-13,15,17,27H,6-9H2,1-2H3,(H,24,25)/t15-,17-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM50043655
PNG
(CHEMBL3355557 | US10047093, 8-95 | US9416132, 8-95)
Show SMILES N[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(Cl)c3)c2n1
Show InChI InChI=1S/C18H20ClN5/c19-13-3-1-2-12(10-13)16-11-21-24-9-8-17(23-18(16)24)22-15-6-4-14(20)5-7-15/h1-3,8-11,14-15H,4-7,20H2,(H,22,23)/t14-,15-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM50043655
PNG
(CHEMBL3355557 | US10047093, 8-95 | US9416132, 8-95)
Show SMILES N[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(Cl)c3)c2n1
Show InChI InChI=1S/C18H20ClN5/c19-13-3-1-2-12(10-13)16-11-21-24-9-8-17(23-18(16)24)22-15-6-4-14(20)5-7-15/h1-3,8-11,14-15H,4-7,20H2,(H,22,23)/t14-,15-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM50043674
PNG
(CHEMBL3355550 | US10047093, 8-54 | US9416132, 8-54)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(c3)C(F)(F)F)c2n1
Show InChI InChI=1S/C19H19F3N4O/c20-19(21,22)13-3-1-2-12(10-13)16-11-23-26-9-8-17(25-18(16)26)24-14-4-6-15(27)7-5-14/h1-3,8-11,14-15,27H,4-7H2,(H,24,25)/t14-,15-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM50043690
PNG
(CHEMBL3355544 | US10047093, 8-46 | US9416132, 8-46)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(OC(F)(F)F)c3)c2n1
Show InChI InChI=1S/C19H19F3N4O2/c20-19(21,22)28-15-3-1-2-12(10-15)16-11-23-26-9-8-17(25-18(16)26)24-13-4-6-14(27)7-5-13/h1-3,8-11,13-14,27H,4-7H2,(H,24,25)/t13-,14-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242369
PNG
(US10047093, 8-26 | US9416132, 8-26)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(c3)C#N)n2n1
Show InChI InChI=1S/C19H19N5O/c20-11-13-2-1-3-14(10-13)17-12-21-19-9-8-18(23-24(17)19)22-15-4-6-16(25)7-5-15/h1-3,8-10,12,15-16,25H,4-7H2,(H,22,23)/t15-,16-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242350
PNG
(US10047093, 8-6 | US9416132, 8-6)
Show SMILES CC(C)(O)CNc1ccc2ncc(-c3cccc(OC(F)(F)F)c3)n2n1
Show InChI InChI=1S/C17H17F3N4O2/c1-16(2,25)10-22-14-6-7-15-21-9-13(24(15)23-14)11-4-3-5-12(8-11)26-17(18,19)20/h3-9,25H,10H2,1-2H3,(H,22,23)
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242347
PNG
(US10047093, 8-3 | US9416132, 8-3)
Show SMILES CC(C)(O)CCNc1ccc2ncc(-c3cccc(OC(F)(F)F)c3)n2n1
Show InChI InChI=1S/C18H19F3N4O2/c1-17(2,26)8-9-22-15-6-7-16-23-11-14(25(16)24-15)12-4-3-5-13(10-12)27-18(19,20)21/h3-7,10-11,26H,8-9H2,1-2H3,(H,22,24)
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242368
PNG
(US10047093, 8-25 | US9416132, 8-25)
Show SMILES N[C@H]1CCCN(C1)c1ccc2ncc(-c3cccc(OC(F)(F)F)c3)n2n1
Show InChI InChI=1S/C18H18F3N5O/c19-18(20,21)27-14-5-1-3-12(9-14)15-10-23-16-6-7-17(24-26(15)16)25-8-2-4-13(22)11-25/h1,3,5-7,9-10,13H,2,4,8,11,22H2/t13-/m0/s1
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242376
PNG
(US10047093, 8-33 | US9416132, 8-33)
Show SMILES FC(F)(F)c1cccc(c1)-c1cnc2ccc(NC3CCOCC3)nn12
Show InChI InChI=1S/C18H17F3N4O/c19-18(20,21)13-3-1-2-12(10-13)15-11-22-17-5-4-16(24-25(15)17)23-14-6-8-26-9-7-14/h1-5,10-11,14H,6-9H2,(H,23,24)
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242399
PNG
(US10047093, 8-82 | US9416132, 8-82)
Show SMILES CC(C)(O)[C@@H]1CC[C@H](C1)Nc1ccc2ncc(-c3cccc(Cl)c3)n2n1
Show InChI InChI=1S/C20H23ClN4O/c1-20(2,26)14-6-7-16(11-14)23-18-8-9-19-22-12-17(25(19)24-18)13-4-3-5-15(21)10-13/h3-5,8-10,12,14,16,26H,6-7,11H2,1-2H3,(H,23,24)/t14-,16-/m1/s1
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242367
PNG
(US10047093, 8-24 | US9416132, 8-24)
Show SMILES NCC1CCN(C(=O)C1)c1ccc2ncc(-c3cccc(OC(F)(F)F)c3)n2n1
Show InChI InChI=1S/C19H18F3N5O2/c20-19(21,22)29-14-3-1-2-13(9-14)15-11-24-16-4-5-17(25-27(15)16)26-7-6-12(10-23)8-18(26)28/h1-5,9,11-12H,6-8,10,23H2
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242349
PNG
(US10047093, 8-5 | US9416132, 8-5)
Show SMILES O[C@@H]1CC[C@H](C1)Nc1ccc2ncc(-c3cccc(OC(F)(F)F)c3)n2n1
Show InChI InChI=1S/C18H17F3N4O2/c19-18(20,21)27-14-3-1-2-11(8-14)15-10-22-17-7-6-16(24-25(15)17)23-12-4-5-13(26)9-12/h1-3,6-8,10,12-13,26H,4-5,9H2,(H,23,24)/t12-,13-/m1/s1
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242405
PNG
(US10047093, 8-92 | US9416132, 8-92)
Show SMILES ON=C1CCC(CC1)Nc1ccc2ncc(-c3cccc(Cl)c3)n2n1
Show InChI InChI=1S/C18H18ClN5O/c19-13-3-1-2-12(10-13)16-11-20-18-9-8-17(22-24(16)18)21-14-4-6-15(23-25)7-5-14/h1-3,8-11,14,25H,4-7H2,(H,21,22)/b23-15-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242365
PNG
(US10047093, 8-22 | US9416132, 8-22)
Show SMILES CN1CCC(O)(CNc2ccc3ncc(-c4cccc(OC(F)(F)F)c4)n3n2)CC1
Show InChI InChI=1S/C20H22F3N5O2/c1-27-9-7-19(29,8-10-27)13-25-17-5-6-18-24-12-16(28(18)26-17)14-3-2-4-15(11-14)30-20(21,22)23/h2-6,11-12,29H,7-10,13H2,1H3,(H,25,26)
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM50043693
PNG
(CHEMBL3355541 | US10047093, 8-67 | US9416132, 8-67)
Show SMILES CN1CCC(CNc2ccn3ncc(-c4cccc(OC(F)(F)F)c4)c3n2)CC1
Show InChI InChI=1S/C20H22F3N5O/c1-27-8-5-14(6-9-27)12-24-18-7-10-28-19(26-18)17(13-25-28)15-3-2-4-16(11-15)29-20(21,22)23/h2-4,7,10-11,13-14H,5-6,8-9,12H2,1H3,(H,24,26)
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242364
PNG
(US10047093, 8-21 | US9416132, 8-21)
Show SMILES FC(F)(F)Oc1cccc(c1)-c1cnc2ccc(NCC3CCN(CC3)C(=O)CN3CCOCC3)nn12
Show InChI InChI=1S/C25H29F3N6O3/c26-25(27,28)37-20-3-1-2-19(14-20)21-16-30-23-5-4-22(31-34(21)23)29-15-18-6-8-33(9-7-18)24(35)17-32-10-12-36-13-11-32/h1-5,14,16,18H,6-13,15,17H2,(H,29,31)
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM35052
PNG
(K00152 | US10047093, 8-39 | US9416132, 8-39)
Show SMILES Clc1cccc(c1)-c1cnc2ccc(NC3CCOCC3)nn12
Show InChI InChI=1S/C17H17ClN4O/c18-13-3-1-2-12(10-13)15-11-19-17-5-4-16(21-22(15)17)20-14-6-8-23-9-7-14/h1-5,10-11,14H,6-9H2,(H,20,21)
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242398
PNG
(US10047093, 8-80 | US9416132, 8-80)
Show SMILES CS(=O)(=O)N[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(Cl)c3)n2n1
Show InChI InChI=1S/C19H22ClN5O2S/c1-28(26,27)24-16-7-5-15(6-8-16)22-18-9-10-19-21-12-17(25(19)23-18)13-3-2-4-14(20)11-13/h2-4,9-12,15-16,24H,5-8H2,1H3,(H,22,23)/t15-,16-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242361
PNG
(US10047093, 8-18 | US9416132, 8-18)
Show SMILES FC(F)(F)Oc1cccc(c1)-c1cnc2ccc(NCC3CCSCC3)nn12
Show InChI InChI=1S/C19H19F3N4OS/c20-19(21,22)27-15-3-1-2-14(10-15)16-12-24-18-5-4-17(25-26(16)18)23-11-13-6-8-28-9-7-13/h1-5,10,12-13H,6-9,11H2,(H,23,25)
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM50043663
PNG
(CHEMBL3355551 | US9416132, 8-55)
Show SMILES C[C@]1(O)CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(c3)C(F)(F)F)c2n1
Show InChI InChI=1S/C20H21F3N4O/c1-19(28)8-5-15(6-9-19)25-17-7-10-27-18(26-17)16(12-24-27)13-3-2-4-14(11-13)20(21,22)23/h2-4,7,10-12,15,28H,5-6,8-9H2,1H3,(H,25,26)/t15-,19-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242393
PNG
(US10047093, 8-75 | US9416132, 8-75)
Show SMILES CC(C)(O)[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(F)c3)n2n1
Show InChI InChI=1S/C21H25FN4O/c1-21(2,27)15-6-8-17(9-7-15)24-19-10-11-20-23-13-18(26(20)25-19)14-4-3-5-16(22)12-14/h3-5,10-13,15,17,27H,6-9H2,1-2H3,(H,24,25)/t15-,17-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242391
PNG
(US10047093, 8-72 | US9416132, 8-72)
Show SMILES Clc1cccc(c1)-c1cnc2ccc(NC3CCC(=O)CC3)nn12
Show InChI InChI=1S/C18H17ClN4O/c19-13-3-1-2-12(10-13)16-11-20-18-9-8-17(22-23(16)18)21-14-4-6-15(24)7-5-14/h1-3,8-11,14H,4-7H2,(H,21,22)
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242356
PNG
(US10047093, 8-13 | US9416132, 8-13)
Show SMILES FC(F)(F)Oc1cccc(c1)-c1cnc2ccc(NCC3CCS(=O)(=O)CC3)nn12
Show InChI InChI=1S/C19H19F3N4O3S/c20-19(21,22)29-15-3-1-2-14(10-15)16-12-24-18-5-4-17(25-26(16)18)23-11-13-6-8-30(27,28)9-7-13/h1-5,10,12-13H,6-9,11H2,(H,23,25)
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM50043658
PNG
(CHEMBL3355553 | US9416132, 8-57)
Show SMILES CO[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(c3)C(F)(F)F)c2n1
Show InChI InChI=1S/C20H21F3N4O/c1-28-16-7-5-15(6-8-16)25-18-9-10-27-19(26-18)17(12-24-27)13-3-2-4-14(11-13)20(21,22)23/h2-4,9-12,15-16H,5-8H2,1H3,(H,25,26)/t15-,16-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242409
PNG
(US9416132, 8-64)
Show SMILES CO[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(Cl)c3)c2n1
Show InChI InChI=1S/C19H21ClN4O/c1-25-16-7-5-15(6-8-16)22-18-9-10-24-19(23-18)17(12-21-24)13-3-2-4-14(20)11-13/h2-4,9-12,15-16H,5-8H2,1H3,(H,22,23)/t15-,16-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242404
PNG
(US9416132, 8-88)
Show SMILES Clc1cccc(c1)-c1cnc2ccc(NC[C@H]3CC[C@@H](CC3)C#N)nn12
Show InChI InChI=1S/C20H20ClN5/c21-17-3-1-2-16(10-17)18-13-24-20-9-8-19(25-26(18)20)23-12-15-6-4-14(11-22)5-7-15/h1-3,8-10,13-15H,4-7,12H2,(H,23,25)/t14-,15-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242423
PNG
(US10047093, 8-108 | US9416132, 8-108)
Show SMILES C[C@]1(O)CC[C@@H](CC1)Nc1ccc2nnc(-c3cccc(c3)C(F)(F)F)n2c1
Show InChI InChI=1S/C20H21F3N4O/c1-19(28)9-7-15(8-10-19)24-16-5-6-17-25-26-18(27(17)12-16)13-3-2-4-14(11-13)20(21,22)23/h2-6,11-12,15,24,28H,7-10H2,1H3/t15-,19-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM50364803
PNG
(CHEMBL1952325 | US10047093, 8-12 | US9416132, 8-12)
Show SMILES FC(F)(F)Oc1cccc(c1)-c1cnc2ccc(NC3CCOCC3)nn12
Show InChI InChI=1S/C18H17F3N4O2/c19-18(20,21)27-14-3-1-2-12(10-14)15-11-22-17-5-4-16(24-25(15)17)23-13-6-8-26-9-7-13/h1-5,10-11,13H,6-9H2,(H,23,24)
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242414
PNG
(US9416132, 8-99)
Show SMILES CO[C@H]1CC[C@@H](CC1)Nc1ccc2nnc(-c3cccc(OC(F)(F)F)c3)n2c1
Show InChI InChI=1S/C20H21F3N4O2/c1-28-16-8-5-14(6-9-16)24-15-7-10-18-25-26-19(27(18)12-15)13-3-2-4-17(11-13)29-20(21,22)23/h2-4,7,10-12,14,16,24H,5-6,8-9H2,1H3/t14-,16-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242400
PNG
(US10047093, 8-83 | US9416132, 8-83)
Show SMILES Clc1cccc(c1)-c1cnc2ccc(N[C@H]3CC[C@@H](CC3)NC=O)nn12
Show InChI InChI=1S/C19H20ClN5O/c20-14-3-1-2-13(10-14)17-11-21-19-9-8-18(24-25(17)19)23-16-6-4-15(5-7-16)22-12-26/h1-3,8-12,15-16H,4-7H2,(H,22,26)(H,23,24)/t15-,16-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242411
PNG
(BDBM50043702 | US9416132, 8-96)
Show SMILES N[C@H]1CCCN(C1)c1ccn2ncc(-c3cccc(Cl)c3)c2n1
Show InChI InChI=1S/C17H18ClN5/c18-13-4-1-3-12(9-13)15-10-20-23-8-6-16(21-17(15)23)22-7-2-5-14(19)11-22/h1,3-4,6,8-10,14H,2,5,7,11,19H2/t14-/m0/s1
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242373
PNG
(US10047093, 8-30 | US9416132, 8-30)
Show SMILES C[C@]1(O)CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(c3)C(F)(F)F)n2n1
Show InChI InChI=1S/C20H21F3N4O/c1-19(28)9-7-15(8-10-19)25-17-5-6-18-24-12-16(27(18)26-17)13-3-2-4-14(11-13)20(21,22)23/h2-6,11-12,15,28H,7-10H2,1H3,(H,25,26)/t15-,19-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM50043656
PNG
(CHEMBL3355555 | US10047093, 8-59 | US9416132, 8-59)
Show SMILES FC(F)(F)c1cccc(c1)-c1cnn2ccc(NCC3CCS(=O)(=O)CC3)nc12
Show InChI InChI=1S/C19H19F3N4O2S/c20-19(21,22)15-3-1-2-14(10-15)16-12-24-26-7-4-17(25-18(16)26)23-11-13-5-8-29(27,28)9-6-13/h1-4,7,10,12-13H,5-6,8-9,11H2,(H,23,25)
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242375
PNG
(US9416132, 8-32)
Show SMILES CO[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(c3)C(F)(F)F)n2n1
Show InChI InChI=1S/C20H21F3N4O/c1-28-16-7-5-15(6-8-16)25-18-9-10-19-24-12-17(27(19)26-18)13-3-2-4-14(11-13)20(21,22)23/h2-4,9-12,15-16H,5-8H2,1H3,(H,25,26)/t15-,16-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM50043691
PNG
(CHEMBL3355543 | US10047093, 8-53 | US9416132, 8-53)
Show SMILES N[C@H]1CCCN(C1)c1ccn2ncc(-c3cccc(OC(F)(F)F)c3)c2n1
Show InChI InChI=1S/C18H18F3N5O/c19-18(20,21)27-14-5-1-3-12(9-14)15-10-23-26-8-6-16(24-17(15)26)25-7-2-4-13(22)11-25/h1,3,5-6,8-10,13H,2,4,7,11,22H2/t13-/m0/s1
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242379
PNG
(US10047093, 8-36 | US9416132, 8-36)
Show SMILES C[C@]1(O)CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(Cl)c3)n2n1
Show InChI InChI=1S/C19H21ClN4O/c1-19(25)9-7-15(8-10-19)22-17-5-6-18-21-12-16(24(18)23-17)13-3-2-4-14(20)11-13/h2-6,11-12,15,25H,7-10H2,1H3,(H,22,23)/t15-,19-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM50043685
PNG
(CHEMBL3355549 | US10047093, 8-51 | US9416132, 8-51)
Show SMILES FC(F)(F)Oc1cccc(c1)-c1cnn2ccc(NCC3CCS(=O)(=O)CC3)nc12
Show InChI InChI=1S/C19H19F3N4O3S/c20-19(21,22)29-15-3-1-2-14(10-15)16-12-24-26-7-4-17(25-18(16)26)23-11-13-5-8-30(27,28)9-6-13/h1-4,7,10,12-13H,5-6,8-9,11H2,(H,23,25)
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242407
PNG
(US10047093, 8-58 | US9416132, 8-58)
Show SMILES FC(F)(F)c1cccc(c1)-c1cnn2ccc(NC3CCOCC3)nc12
Show InChI InChI=1S/C18H17F3N4O/c19-18(20,21)13-3-1-2-12(10-13)15-11-22-25-7-4-16(24-17(15)25)23-14-5-8-26-9-6-14/h1-4,7,10-11,14H,5-6,8-9H2,(H,23,24)
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242386
PNG
(US10047093, 8-44 | US9416132, 8-44)
Show SMILES FC(F)(F)Oc1cccc(c1)-c1cnc2ccc(NCCN3CCOCC3)nn12
Show InChI InChI=1S/C19H20F3N5O2/c20-19(21,22)29-15-3-1-2-14(12-15)16-13-24-18-5-4-17(25-27(16)18)23-6-7-26-8-10-28-11-9-26/h1-5,12-13H,6-11H2,(H,23,25)
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM50043695
PNG
(CHEMBL3355990 | US10047093, 8-66 | US9416132, 8-66)
Show SMILES Clc1cccc(c1)-c1cnn2ccc(NCC3CCS(=O)(=O)CC3)nc12
Show InChI InChI=1S/C18H19ClN4O2S/c19-15-3-1-2-14(10-15)16-12-21-23-7-4-17(22-18(16)23)20-11-13-5-8-26(24,25)9-6-13/h1-4,7,10,12-13H,5-6,8-9,11H2,(H,20,22)
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242412
PNG
(US10047093, 8-97 | US9416132, 8-97)
Show SMILES Clc1cccc(c1)-c1cnn2ccc(NC3CCC(=O)CC3)nc12
Show InChI InChI=1S/C18H17ClN4O/c19-13-3-1-2-12(10-13)16-11-20-23-9-8-17(22-18(16)23)21-14-4-6-15(24)7-5-14/h1-3,8-11,14H,4-7H2,(H,21,22)
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242360
PNG
(US10047093, 8-17 | US9416132, 8-17)
Show SMILES FC(F)(F)Oc1cccc(c1)-c1cnc2ccc(NCC3CCC(F)(F)CC3)nn12
Show InChI InChI=1S/C20H19F5N4O/c21-19(22)8-6-13(7-9-19)11-26-17-4-5-18-27-12-16(29(18)28-17)14-2-1-3-15(10-14)30-20(23,24)25/h1-5,10,12-13H,6-9,11H2,(H,26,28)
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242410
PNG
(US10047093, 8-65 | US9416132, 8-65)
Show SMILES Clc1cccc(c1)-c1cnn2ccc(NC3CCOCC3)nc12
Show InChI InChI=1S/C17H17ClN4O/c18-13-3-1-2-12(10-13)15-11-19-22-7-4-16(21-17(15)22)20-14-5-8-23-9-6-14/h1-4,7,10-11,14H,5-6,8-9H2,(H,20,21)
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM50043689
PNG
(CHEMBL3355545 | US10047093, 8-48 | US9416132, 8-48)
Show SMILES C[C@]1(O)CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(OC(F)(F)F)c3)c2n1
Show InChI InChI=1S/C20H21F3N4O2/c1-19(28)8-5-14(6-9-19)25-17-7-10-27-18(26-17)16(12-24-27)13-3-2-4-15(11-13)29-20(21,22)23/h2-4,7,10-12,14,28H,5-6,8-9H2,1H3,(H,25,26)/t14-,19-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242382
PNG
(US10047093, 8-40 | US9416132, 8-40)
Show SMILES Clc1cccc(c1)-c1cnc2ccc(NCC3CCS(=O)(=O)CC3)nn12
Show InChI InChI=1S/C18H19ClN4O2S/c19-15-3-1-2-14(10-15)16-12-21-18-5-4-17(22-23(16)18)20-11-13-6-8-26(24,25)9-7-13/h1-5,10,12-13H,6-9,11H2,(H,20,22)
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM50043688
PNG
(CHEMBL3355546 | US10047093, 8-47 | US9416132, 8-47)
Show SMILES CC(C)(O)[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(OC(F)(F)F)c3)c2n1
Show InChI InChI=1S/C22H25F3N4O2/c1-21(2,30)15-6-8-16(9-7-15)27-19-10-11-29-20(28-19)18(13-26-29)14-4-3-5-17(12-14)31-22(23,24)25/h3-5,10-13,15-16,30H,6-9H2,1-2H3,(H,27,28)/t15-,16-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242396
PNG
(US10047093, 8-78 | US9416132, 8-78)
Show SMILES CC(C)(C)N[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(Cl)c3)n2n1
Show InChI InChI=1S/C22H28ClN5/c1-22(2,3)26-18-9-7-17(8-10-18)25-20-11-12-21-24-14-19(28(21)27-20)15-5-4-6-16(23)13-15/h4-6,11-14,17-18,26H,7-10H2,1-3H3,(H,25,27)/t17-,18-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242383
PNG
(US10047093, 8-41 | US9416132, 8-41)
Show SMILES CC(C)(O)CCOc1ccc2ncc(-c3cccc(OC(F)(F)F)c3)n2n1
Show InChI InChI=1S/C18H18F3N3O3/c1-17(2,25)8-9-26-16-7-6-15-22-11-14(24(15)23-16)12-4-3-5-13(10-12)27-18(19,20)21/h3-7,10-11,25H,8-9H2,1-2H3
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM50043701
PNG
(CHEMBL3355559 | US10047093, 8-61 | US9416132, 8-61)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(Cl)c3)c2n1
Show InChI InChI=1S/C18H19ClN4O/c19-13-3-1-2-12(10-13)16-11-20-23-9-8-17(22-18(16)23)21-14-4-6-15(24)7-5-14/h1-3,8-11,14-15,24H,4-7H2,(H,21,22)/t14-,15-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242401
PNG
(US10047093, 8-84 | US9416132, 8-84)
Show SMILES Clc1cccc(c1)-c1cnc2ccc(N[C@H]3CC[C@@H](CC3)NC(=O)CN3CCOCC3)nn12
Show InChI InChI=1S/C24H29ClN6O2/c25-18-3-1-2-17(14-18)21-15-26-23-9-8-22(29-31(21)23)27-19-4-6-20(7-5-19)28-24(32)16-30-10-12-33-13-11-30/h1-3,8-9,14-15,19-20H,4-7,10-13,16H2,(H,27,29)(H,28,32)/t19-,20-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242377
PNG
(US10047093, 8-34 | US9416132, 8-34)
Show SMILES FC(F)(F)c1cccc(c1)-c1cnc2ccc(NCC3CCS(=O)(=O)CC3)nn12
Show InChI InChI=1S/C19H19F3N4O2S/c20-19(21,22)15-3-1-2-14(10-15)16-12-24-18-5-4-17(25-26(16)18)23-11-13-6-8-29(27,28)9-7-13/h1-5,10,12-13H,6-9,11H2,(H,23,25)
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM50043700
PNG
(CHEMBL3355560 | US10047093, 8-62 | US9416132, 8-62)
Show SMILES C[C@]1(O)CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(Cl)c3)c2n1
Show InChI InChI=1S/C19H21ClN4O/c1-19(25)8-5-15(6-9-19)22-17-7-10-24-18(23-17)16(12-21-24)13-3-2-4-14(20)11-13/h2-4,7,10-12,15,25H,5-6,8-9H2,1H3,(H,22,23)/t15-,19-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM50043687
PNG
(CHEMBL3355547 | US9416132, 8-49)
Show SMILES CO[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(OC(F)(F)F)c3)c2n1
Show InChI InChI=1S/C20H21F3N4O2/c1-28-15-7-5-14(6-8-15)25-18-9-10-27-19(26-18)17(12-24-27)13-3-2-4-16(11-13)29-20(21,22)23/h2-4,9-12,14-15H,5-8H2,1H3,(H,25,26)/t14-,15-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242413
PNG
(US10047093, 8-98 | US9416132, 8-98)
Show SMILES CC(C)(O)[C@H]1CC[C@@H](CC1)Nc1cc(N)n2ncc(-c3cccc(OC(F)(F)F)c3)c2n1
Show InChI InChI=1S/C22H26F3N5O2/c1-21(2,31)14-6-8-15(9-7-14)28-19-11-18(26)30-20(29-19)17(12-27-30)13-4-3-5-16(10-13)32-22(23,24)25/h3-5,10-12,14-15,31H,6-9,26H2,1-2H3,(H,28,29)/t14-,15-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242416
PNG
(US9416132, 8-101)
Show SMILES CC(C)(O)[C@H]1CC[C@@H](CC1)Nc1ccc2nnc(-c3cccc(OC(F)(F)F)c3)n2c1
Show InChI InChI=1S/C22H25F3N4O2/c1-21(2,30)15-6-8-16(9-7-15)26-17-10-11-19-27-28-20(29(19)13-17)14-4-3-5-18(12-14)31-22(23,24)25/h3-5,10-13,15-16,26,30H,6-9H2,1-2H3/t15-,16-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242359
PNG
(US10047093, 8-16 | US9416132, 8-16)
Show SMILES CC(C)O[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(OC(F)(F)F)c3)n2n1
Show InChI InChI=1S/C22H25F3N4O2/c1-14(2)30-17-8-6-16(7-9-17)27-20-10-11-21-26-13-19(29(21)28-20)15-4-3-5-18(12-15)31-22(23,24)25/h3-5,10-14,16-17H,6-9H2,1-2H3,(H,27,28)/t16-,17-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242421
PNG
(US9416132, 8-106)
Show SMILES CO[C@H]1CC[C@@H](CC1)Nc1ccc2nnc(-c3cccc(c3)C(F)(F)F)n2c1
Show InChI InChI=1S/C20H21F3N4O/c1-28-17-8-5-15(6-9-17)24-16-7-10-18-25-26-19(27(18)12-16)13-3-2-4-14(11-13)20(21,22)23/h2-4,7,10-12,15,17,24H,5-6,8-9H2,1H3/t15-,17-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242385
PNG
(US9416132, 8-43)
Show SMILES COc1ccc(CNc2ccc3ncc(-c4cccc(OC(F)(F)F)c4)n3n2)cc1
Show InChI InChI=1S/C21H17F3N4O2/c1-29-16-7-5-14(6-8-16)12-25-19-9-10-20-26-13-18(28(20)27-19)15-3-2-4-17(11-15)30-21(22,23)24/h2-11,13H,12H2,1H3,(H,25,27)
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242371
PNG
(US10047093, 8-28 | US9416132, 8-28)
Show SMILES FC(F)(F)Oc1cccc(c1)-c1cnc2ccc(OCC3CCOCC3)nn12
Show InChI InChI=1S/C19H18F3N3O3/c20-19(21,22)28-15-3-1-2-14(10-15)16-11-23-17-4-5-18(24-25(16)17)27-12-13-6-8-26-9-7-13/h1-5,10-11,13H,6-9,12H2
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242406
PNG
(US10047093, 8-50 | US9416132, 8-50)
Show SMILES FC(F)(F)Oc1cccc(c1)-c1cnn2ccc(NC3CCOCC3)nc12
Show InChI InChI=1S/C18H17F3N4O2/c19-18(20,21)27-14-3-1-2-12(10-14)15-11-22-25-7-4-16(24-17(15)25)23-13-5-8-26-9-6-13/h1-4,7,10-11,13H,5-6,8-9H2,(H,23,24)
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242419
PNG
(US10047093, 8-104 | US9416132, 8-104)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1ccc2nnc(-c3cccc(OC(F)(F)F)c3)n2c1
Show InChI InChI=1S/C19H19F3N4O2/c20-19(21,22)28-16-3-1-2-12(10-16)18-25-24-17-9-6-14(11-26(17)18)23-13-4-7-15(27)8-5-13/h1-3,6,9-11,13,15,23,27H,4-5,7-8H2/t13-,15-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242394
PNG
(US10047093, 8-76 | US9416132, 8-76)
Show SMILES CC(C)(O)[C@H]1CC[C@H](CNc2ccc3ncc(-c4cccc(Cl)c4)n3n2)CC1
Show InChI InChI=1S/C22H27ClN4O/c1-22(2,28)17-8-6-15(7-9-17)13-24-20-10-11-21-25-14-19(27(21)26-20)16-4-3-5-18(23)12-16/h3-5,10-12,14-15,17,28H,6-9,13H2,1-2H3,(H,24,26)/t15-,17-
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n/an/a 687n/an/an/an/an/an/a



Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242428
PNG
(US9416132, 8-113)
Show SMILES CO[C@H]1CC[C@@H](CC1)Nc1ccc2nnc(-c3cccc(Cl)c3)n2c1
Show InChI InChI=1S/C19H21ClN4O/c1-25-17-8-5-15(6-9-17)21-16-7-10-18-22-23-19(24(18)12-16)13-3-2-4-14(20)11-13/h2-4,7,10-12,15,17,21H,5-6,8-9H2,1H3/t15-,17-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242357
PNG
(US10047093, 8-14 | US9416132, 8-14)
Show SMILES FC(F)(F)Oc1cccc(c1)-c1cnc2ccc(NC3CCS(=O)(=O)CC3)nn12
Show InChI InChI=1S/C18H17F3N4O3S/c19-18(20,21)28-14-3-1-2-12(10-14)15-11-22-17-5-4-16(24-25(15)17)23-13-6-8-29(26,27)9-7-13/h1-5,10-11,13H,6-9H2,(H,23,24)
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242366
PNG
(US10047093, 8-23 | US9416132, 8-23)
Show SMILES FC(F)(F)Oc1cccc(c1)-c1cnc2ccc(NCC3CCNC(=O)C3)nn12
Show InChI InChI=1S/C19H18F3N5O2/c20-19(21,22)29-14-3-1-2-13(9-14)15-11-25-17-5-4-16(26-27(15)17)24-10-12-6-7-23-18(28)8-12/h1-5,9,11-12H,6-8,10H2,(H,23,28)(H,24,26)
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n/an/a 1.63E+3n/an/an/an/an/an/a



Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242415
PNG
(US10047093, 8-100 | US9416132, 8-100)
Show SMILES C[C@]1(O)CC[C@@H](CC1)Nc1ccc2nnc(-c3cccc(OC(F)(F)F)c3)n2c1
Show InChI InChI=1S/C20H21F3N4O2/c1-19(28)9-7-14(8-10-19)24-15-5-6-17-25-26-18(27(17)12-15)13-3-2-4-16(11-13)29-20(21,22)23/h2-6,11-12,14,24,28H,7-10H2,1H3/t14-,19-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242384
PNG
(US9416132, 8-42)
Show SMILES COCCOc1ccc2ncc(-c3cccc(OC(F)(F)F)c3)n2n1
Show InChI InChI=1S/C16H14F3N3O3/c1-23-7-8-24-15-6-5-14-20-10-13(22(14)21-15)11-3-2-4-12(9-11)25-16(17,18)19/h2-6,9-10H,7-8H2,1H3
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242420
PNG
(US10047093, 8-105 | US9416132, 8-105)
Show SMILES FC(F)(F)Oc1cccc(c1)-c1nnc2ccc(N[C@@H]3CC[C@H](Br)CC3)cn12
Show InChI InChI=1S/C19H18BrF3N4O/c20-13-4-6-14(7-5-13)24-15-8-9-17-25-26-18(27(17)11-15)12-2-1-3-16(10-12)28-19(21,22)23/h1-3,8-11,13-14,24H,4-7H2/t13-,14+
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242358
PNG
(US10047093, 8-15 | US9416132, 8-15)
Show SMILES FC(F)(F)Oc1cccc(c1)-c1cnc2ccc(nn12)N1CCS(=O)(=O)CC1
Show InChI InChI=1S/C17H15F3N4O3S/c18-17(19,20)27-13-3-1-2-12(10-13)14-11-21-15-4-5-16(22-24(14)15)23-6-8-28(25,26)9-7-23/h1-5,10-11H,6-9H2
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242425
PNG
(US10047093, 8-110 | US9416132, 8-110)
Show SMILES FC(F)(F)c1cccc(c1)-c1nnc2ccc(NC3CCOCC3)cn12
Show InChI InChI=1S/C18H17F3N4O/c19-18(20,21)13-3-1-2-12(10-13)17-24-23-16-5-4-15(11-25(16)17)22-14-6-8-26-9-7-14/h1-5,10-11,14,22H,6-9H2
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242417
PNG
(US10047093, 8-102 | US9416132, 8-102)
Show SMILES FC(F)(F)Oc1cccc(c1)-c1nnc2ccc(NC3CCOCC3)cn12
Show InChI InChI=1S/C18H17F3N4O2/c19-18(20,21)27-15-3-1-2-12(10-15)17-24-23-16-5-4-14(11-25(16)17)22-13-6-8-26-9-7-13/h1-5,10-11,13,22H,6-9H2
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242418
PNG
(US10047093, 8-111 | US9416132, 8-103)
Show SMILES FC(F)(F)Oc1cccc(c1)-c1nnc2ccc(NCC3CCS(=O)(=O)CC3)cn12
Show InChI InChI=1S/C19H19F3N4O3S/c20-19(21,22)29-16-3-1-2-14(10-16)18-25-24-17-5-4-15(12-26(17)18)23-11-13-6-8-30(27,28)9-7-13/h1-5,10,12-13,23H,6-9,11H2
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242424
PNG
(US10047093, 8-109 | US9416132, 8-109)
Show SMILES CC(C)(O)[C@H]1CC[C@@H](CC1)Nc1ccc2nnc(-c3cccc(c3)C(F)(F)F)n2c1
Show InChI InChI=1S/C22H25F3N4O/c1-21(2,30)15-6-8-17(9-7-15)26-18-10-11-19-27-28-20(29(19)13-18)14-4-3-5-16(12-14)22(23,24)25/h3-5,10-13,15,17,26,30H,6-9H2,1-2H3/t15-,17-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242422
PNG
(US10047093, 8-107 | US9416132, 8-107)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1ccc2nnc(-c3cccc(c3)C(F)(F)F)n2c1
Show InChI InChI=1S/C19H19F3N4O/c20-19(21,22)13-3-1-2-12(10-13)18-25-24-17-9-6-15(11-26(17)18)23-14-4-7-16(27)8-5-14/h1-3,6,9-11,14,16,23,27H,4-5,7-8H2/t14-,16-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM242372
PNG
(US10047093, 8-29 | US9416132, 8-29)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(c3)C(F)(F)F)n2n1
Show InChI InChI=1S/C19H19F3N4O/c20-19(21,22)13-3-1-2-12(10-13)16-11-23-18-9-8-17(25-26(16)18)24-14-4-6-15(27)7-5-14/h1-3,8-11,14-15,27H,4-7H2,(H,24,25)/t14-,15-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
Representative compounds were tested for hERG activity using the Fast Patch assay available from WuXiApptec (Shanghai China).


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM242356
PNG
(US10047093, 8-13 | US9416132, 8-13)
Show SMILES FC(F)(F)Oc1cccc(c1)-c1cnc2ccc(NCC3CCS(=O)(=O)CC3)nn12
Show InChI InChI=1S/C19H19F3N4O3S/c20-19(21,22)29-15-3-1-2-14(10-15)16-12-24-18-5-4-17(25-26(16)18)23-11-13-6-8-30(27,28)9-7-13/h1-5,10,12-13H,6-9,11H2,(H,23,25)
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
Representative compounds were tested for hERG activity using the Fast Patch assay available from WuXiApptec (Shanghai China).


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM242373
PNG
(US10047093, 8-30 | US9416132, 8-30)
Show SMILES C[C@]1(O)CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(c3)C(F)(F)F)n2n1
Show InChI InChI=1S/C20H21F3N4O/c1-19(28)9-7-15(8-10-19)25-17-5-6-18-24-12-16(27(18)26-17)13-3-2-4-14(11-13)20(21,22)23/h2-6,11-12,15,28H,7-10H2,1H3,(H,25,26)/t15-,19-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
Representative compounds were tested for hERG activity using the Fast Patch assay available from WuXiApptec (Shanghai China).


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM242345
PNG
(US10047093, 8-1 | US9416132, 8-1)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(OC(F)(F)F)c3)n2n1
Show InChI InChI=1S/C19H19F3N4O2/c20-19(21,22)28-15-3-1-2-12(10-15)16-11-23-18-9-8-17(25-26(16)18)24-13-4-6-14(27)7-5-13/h1-3,8-11,13-14,27H,4-7H2,(H,24,25)/t13-,14-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
Representative compounds were tested for hERG activity using the Fast Patch assay available from WuXiApptec (Shanghai China).


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM242353
PNG
(US10047093, 8-9 | US9416132, 8-9)
Show SMILES C[C@]1(O)CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(OC(F)(F)F)c3)n2n1
Show InChI InChI=1S/C20H21F3N4O2/c1-19(28)9-7-14(8-10-19)25-17-5-6-18-24-12-16(27(18)26-17)13-3-2-4-15(11-13)29-20(21,22)23/h2-6,11-12,14,28H,7-10H2,1H3,(H,25,26)/t14-,19-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
Representative compounds were tested for hERG activity using the Fast Patch assay available from WuXiApptec (Shanghai China).


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM35052
PNG
(K00152 | US10047093, 8-39 | US9416132, 8-39)
Show SMILES Clc1cccc(c1)-c1cnc2ccc(NC3CCOCC3)nn12
Show InChI InChI=1S/C17H17ClN4O/c18-13-3-1-2-12(10-13)15-11-19-17-5-4-16(21-22(15)17)20-14-6-8-23-9-7-14/h1-5,10-11,14H,6-9H2,(H,20,21)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
Representative compounds were tested for hERG activity using the Fast Patch assay available from WuXiApptec (Shanghai China).


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM242354
PNG
(US10047093, 8-10 | US9416132, 8-10)
Show SMILES CC(C)(O)[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(OC(F)(F)F)c3)n2n1
Show InChI InChI=1S/C22H25F3N4O2/c1-21(2,30)15-6-8-16(9-7-15)27-19-10-11-20-26-13-18(29(20)28-19)14-4-3-5-17(12-14)31-22(23,24)25/h3-5,10-13,15-16,30H,6-9H2,1-2H3,(H,27,28)/t15-,16-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
Representative compounds were tested for hERG activity using the Fast Patch assay available from WuXiApptec (Shanghai China).


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM242409
PNG
(US9416132, 8-64)
Show SMILES CO[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(Cl)c3)c2n1
Show InChI InChI=1S/C19H21ClN4O/c1-25-16-7-5-15(6-8-16)22-18-9-10-24-19(23-18)17(12-21-24)13-3-2-4-14(20)11-13/h2-4,9-12,15-16H,5-8H2,1H3,(H,22,23)/t15-,16-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
Representative compounds were tested for hERG activity using the Fast Patch assay available from WuXiApptec (Shanghai China).


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50043662
PNG
(CHEMBL3355552 | US10047093, 8-56 | US9416132, 8-56)
Show SMILES CC(C)(O)[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(c3)C(F)(F)F)c2n1
Show InChI InChI=1S/C22H25F3N4O/c1-21(2,30)15-6-8-17(9-7-15)27-19-10-11-29-20(28-19)18(13-26-29)14-4-3-5-16(12-14)22(23,24)25/h3-5,10-13,15,17,30H,6-9H2,1-2H3,(H,27,28)/t15-,17-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
Representative compounds were tested for hERG activity using the Fast Patch assay available from WuXiApptec (Shanghai China).


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM242378
PNG
(US10047093, 8-35 | US9416132, 8-35)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(Cl)c3)n2n1
Show InChI InChI=1S/C18H19ClN4O/c19-13-3-1-2-12(10-13)16-11-20-18-9-8-17(22-23(16)18)21-14-4-6-15(24)7-5-14/h1-3,8-11,14-15,24H,4-7H2,(H,21,22)/t14-,15-
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n/an/a 3.00E+4n/an/an/an/an/an/a



Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
Representative compounds were tested for hERG activity using the Fast Patch assay available from WuXiApptec (Shanghai China).


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM242374
PNG
(US10047093, 8-31 | US9416132, 8-31)
Show SMILES CC(C)(O)[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(c3)C(F)(F)F)n2n1
Show InChI InChI=1S/C22H25F3N4O/c1-21(2,30)15-6-8-17(9-7-15)27-19-10-11-20-26-13-18(29(20)28-19)14-4-3-5-16(12-14)22(23,24)25/h3-5,10-13,15,17,30H,6-9H2,1-2H3,(H,27,28)/t15-,17-
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n/an/a>3.00E+4n/an/an/an/an/an/a



Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
Representative compounds were tested for hERG activity using the Fast Patch assay available from WuXiApptec (Shanghai China).


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM242355
PNG
(US9416132, 8-11)
Show SMILES CO[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(OC(F)(F)F)c3)n2n1
Show InChI InChI=1S/C20H21F3N4O2/c1-28-15-7-5-14(6-8-15)25-18-9-10-19-24-12-17(27(19)26-18)13-3-2-4-16(11-13)29-20(21,22)23/h2-4,9-12,14-15H,5-8H2,1H3,(H,25,26)/t14-,15-
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Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
Representative compounds were tested for hERG activity using the Fast Patch assay available from WuXiApptec (Shanghai China).


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50043697
PNG
(CHEMBL3355987 | US10047093, 8-63 | US9416132, 8-63)
Show SMILES CC(C)(O)[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(Cl)c3)c2n1
Show InChI InChI=1S/C21H25ClN4O/c1-21(2,27)15-6-8-17(9-7-15)24-19-10-11-26-20(25-19)18(13-23-26)14-4-3-5-16(22)12-14/h3-5,10-13,15,17,27H,6-9H2,1-2H3,(H,24,25)/t15-,17-
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n/an/a>3.00E+4n/an/an/an/an/an/a



Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
Representative compounds were tested for hERG activity using the Fast Patch assay available from WuXiApptec (Shanghai China).


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242427
PNG
(US10047093, 8-112 | US9416132, 8-112)
Show SMILES OCCOc1ccc2nnc(-c3cccc(c3)C(F)(F)F)n2c1
Show InChI InChI=1S/C15H12F3N3O2/c16-15(17,18)11-3-1-2-10(8-11)14-20-19-13-5-4-12(9-21(13)14)23-7-6-22/h1-5,8-9,22H,6-7H2
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n/an/a>3.00E+4n/an/an/an/an/an/a



Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50043674
PNG
(CHEMBL3355550 | US10047093, 8-54 | US9416132, 8-54)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(c3)C(F)(F)F)c2n1
Show InChI InChI=1S/C19H19F3N4O/c20-19(21,22)13-3-1-2-12(10-13)16-11-23-26-9-8-17(25-18(16)26)24-14-4-6-15(27)7-5-14/h1-3,8-11,14-15,27H,4-7H2,(H,24,25)/t14-,15-
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n/an/a>3.00E+4n/an/an/an/an/an/a



Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
Representative compounds were tested for hERG activity using the Fast Patch assay available from WuXiApptec (Shanghai China).


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50043690
PNG
(CHEMBL3355544 | US10047093, 8-46 | US9416132, 8-46)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(OC(F)(F)F)c3)c2n1
Show InChI InChI=1S/C19H19F3N4O2/c20-19(21,22)28-15-3-1-2-12(10-15)16-11-23-26-9-8-17(25-18(16)26)24-13-4-6-14(27)7-5-13/h1-3,8-11,13-14,27H,4-7H2,(H,24,25)/t13-,14-
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n/an/a>3.00E+4n/an/an/an/an/an/a



Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
Representative compounds were tested for hERG activity using the Fast Patch assay available from WuXiApptec (Shanghai China).


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM242426
PNG
(US9416132, 8-111)
Show SMILES FC(F)(F)c1cccc(c1)-c1nnc2ccc(NCC3CCS(=O)(=O)CC3)cn12
Show InChI InChI=1S/C19H19F3N4O2S/c20-19(21,22)15-3-1-2-14(10-15)18-25-24-17-5-4-16(12-26(17)18)23-11-13-6-8-29(27,28)9-7-13/h1-5,10,12-13,23H,6-9,11H2
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n/an/a>3.00E+4n/an/an/an/an/an/a



Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM242380
PNG
(US10047093, 8-37 | US9416132, 8-37)
Show SMILES CC(C)(O)[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(Cl)c3)n2n1
Show InChI InChI=1S/C21H25ClN4O/c1-21(2,27)15-6-8-17(9-7-15)24-19-10-11-20-23-13-18(26(20)25-19)14-4-3-5-16(22)12-14/h3-5,10-13,15,17,27H,6-9H2,1-2H3,(H,24,25)/t15-,17-
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n/an/a>3.00E+4n/an/an/an/an/an/a



Tolero Pharmaceuticals, Inc.

US Patent


Assay Description
Representative compounds were tested for hERG activity using the Fast Patch assay available from WuXiApptec (Shanghai China).


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%