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Patent code US9422235

Compile Data Set for Download or QSAR
Found 171 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242438
PNG
(US9422235, 12)
Show SMILES COc1cc(Nc2ccc(cc2)S(=O)(=O)NCC2CC2)cc(OC)c1
Show InChI InChI=1S/C18H22N2O4S/c1-23-16-9-15(10-17(11-16)24-2)20-14-5-7-18(8-6-14)25(21,22)19-12-13-3-4-13/h5-11,13,19-20H,3-4,12H2,1-2H3
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6n/a 11n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242480
PNG
(US9422235, 58)
Show SMILES FC(F)(F)c1cc(NC2CC3CCC2C3)ccc1S(=O)(=O)NCC1CC1
Show InChI InChI=1S/C18H23F3N2O2S/c19-18(20,21)15-9-14(23-16-8-12-3-4-13(16)7-12)5-6-17(15)26(24,25)22-10-11-1-2-11/h5-6,9,11-13,16,22-23H,1-4,7-8,10H2
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12.2n/a 20n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242430
PNG
(US9422235, 3)
Show SMILES FC(F)(F)c1cc(Nc2ccc(Cl)cc2Cl)ccc1S(=O)(=O)NCC1CC1
Show InChI InChI=1S/C17H15Cl2F3N2O2S/c18-11-3-5-15(14(19)7-11)24-12-4-6-16(13(8-12)17(20,21)22)27(25,26)23-9-10-1-2-10/h3-8,10,23-24H,1-2,9H2
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17n/a 30n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242525
PNG
(US9422235, 110)
Show SMILES CC1(C)C2CC1(C)CC(C2)Nc1ccc(c(c1)C(F)(F)F)S(=O)(=O)NCC1CC1
Show InChI InChI=1S/C21H29F3N2O2S/c1-19(2)14-8-16(11-20(19,3)10-14)26-15-6-7-18(17(9-15)21(22,23)24)29(27,28)25-12-13-4-5-13/h6-7,9,13-14,16,25-26H,4-5,8,10-12H2,1-3H3
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18.8n/a 37.2n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242431
PNG
(US9422235, 4)
Show SMILES COc1cc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCC2CC2)cc(OC)c1
Show InChI InChI=1S/C19H21F3N2O4S/c1-27-15-7-14(8-16(10-15)28-2)24-13-5-6-18(17(9-13)19(20,21)22)29(25,26)23-11-12-3-4-12/h5-10,12,23-24H,3-4,11H2,1-2H3
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19n/a 37n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242504
PNG
(US9422235, 87)
Show SMILES FC(F)(F)c1cc(NC2CCCCCC2)ccc1S(=O)(=O)NCC1CC1
Show InChI InChI=1S/C18H25F3N2O2S/c19-18(20,21)16-11-15(23-14-5-3-1-2-4-6-14)9-10-17(16)26(24,25)22-12-13-7-8-13/h9-11,13-14,22-23H,1-8,12H2
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23n/a 37n/an/an/an/an/an/a



Pharmos Corporation

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Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242465
PNG
(US9422235, 41)
Show SMILES FC(F)(F)c1cc(NC2CC3CCC2C3)ccc1S(=O)(=O)NCC1CCOCC1
Show InChI InChI=1S/C20H27F3N2O3S/c21-20(22,23)17-11-16(25-18-10-14-1-2-15(18)9-14)3-4-19(17)29(26,27)24-12-13-5-7-28-8-6-13/h3-4,11,13-15,18,24-25H,1-2,5-10,12H2
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28n/a 48.8n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242435
PNG
(US9422235, 9)
Show SMILES FC(F)(F)c1cc(Nc2ccc(Cl)cc2Cl)ccc1S(=O)(=O)NCC1CCCO1
Show InChI InChI=1S/C18H17Cl2F3N2O3S/c19-11-3-5-16(15(20)8-11)25-12-4-6-17(14(9-12)18(21,22)23)29(26,27)24-10-13-2-1-7-28-13/h3-6,8-9,13,24-25H,1-2,7,10H2
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28n/a 50n/an/an/an/an/an/a



Pharmos Corporation

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Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242467
PNG
(US9422235, 43)
Show SMILES FC(F)(F)c1cc(Nc2ccc(cc2Cl)C#N)ccc1S(=O)(=O)NCC1CC1
Show InChI InChI=1S/C18H15ClF3N3O2S/c19-15-7-12(9-23)3-5-16(15)25-13-4-6-17(14(8-13)18(20,21)22)28(26,27)24-10-11-1-2-11/h3-8,11,24-25H,1-2,10H2
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29n/a 50.2n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242431
PNG
(US9422235, 4)
Show SMILES COc1cc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCC2CC2)cc(OC)c1
Show InChI InChI=1S/C19H21F3N2O4S/c1-27-15-7-14(8-16(10-15)28-2)24-13-5-6-18(17(9-13)19(20,21)22)29(25,26)23-11-12-3-4-12/h5-10,12,23-24H,3-4,11H2,1-2H3
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29n/a 56n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242431
PNG
(US9422235, 4)
Show SMILES COc1cc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCC2CC2)cc(OC)c1
Show InChI InChI=1S/C19H21F3N2O4S/c1-27-15-7-14(8-16(10-15)28-2)24-13-5-6-18(17(9-13)19(20,21)22)29(25,26)23-11-12-3-4-12/h5-10,12,23-24H,3-4,11H2,1-2H3
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29.2n/a 58.1n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242465
PNG
(US9422235, 41)
Show SMILES FC(F)(F)c1cc(NC2CC3CCC2C3)ccc1S(=O)(=O)NCC1CCOCC1
Show InChI InChI=1S/C20H27F3N2O3S/c21-20(22,23)17-11-16(25-18-10-14-1-2-15(18)9-14)3-4-19(17)29(26,27)24-12-13-5-7-28-8-6-13/h3-4,11,13-15,18,24-25H,1-2,5-10,12H2
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32.4n/a 64.5n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242504
PNG
(US9422235, 87)
Show SMILES FC(F)(F)c1cc(NC2CCCCCC2)ccc1S(=O)(=O)NCC1CC1
Show InChI InChI=1S/C18H25F3N2O2S/c19-18(20,21)16-11-15(23-14-5-3-1-2-4-6-14)9-10-17(16)26(24,25)22-12-13-7-8-13/h9-11,13-14,22-23H,1-8,12H2
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33n/a 78n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242431
PNG
(US9422235, 4)
Show SMILES COc1cc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCC2CC2)cc(OC)c1
Show InChI InChI=1S/C19H21F3N2O4S/c1-27-15-7-14(8-16(10-15)28-2)24-13-5-6-18(17(9-13)19(20,21)22)29(25,26)23-11-12-3-4-12/h5-10,12,23-24H,3-4,11H2,1-2H3
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34n/a 76n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242465
PNG
(US9422235, 41)
Show SMILES FC(F)(F)c1cc(NC2CC3CCC2C3)ccc1S(=O)(=O)NCC1CCOCC1
Show InChI InChI=1S/C20H27F3N2O3S/c21-20(22,23)17-11-16(25-18-10-14-1-2-15(18)9-14)3-4-19(17)29(26,27)24-12-13-5-7-28-8-6-13/h3-4,11,13-15,18,24-25H,1-2,5-10,12H2
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34.8n/a 53.1n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242450
PNG
(US9422235, 26)
Show SMILES FC(F)(F)c1cc(NC2CC3CCC2C3)ccc1S(=O)(=O)NCC1CCCO1
Show InChI InChI=1S/C19H25F3N2O3S/c20-19(21,22)16-10-14(24-17-9-12-3-4-13(17)8-12)5-6-18(16)28(25,26)23-11-15-2-1-7-27-15/h5-6,10,12-13,15,17,23-24H,1-4,7-9,11H2
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36n/a 75n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242431
PNG
(US9422235, 4)
Show SMILES COc1cc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCC2CC2)cc(OC)c1
Show InChI InChI=1S/C19H21F3N2O4S/c1-27-15-7-14(8-16(10-15)28-2)24-13-5-6-18(17(9-13)19(20,21)22)29(25,26)23-11-12-3-4-12/h5-10,12,23-24H,3-4,11H2,1-2H3
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37n/a 68n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242437
PNG
(US9422235, 11)
Show SMILES COc1cc(Nc2ccc(c(OC(F)(F)F)c2)S(=O)(=O)NCC2CC2)cc(OC)c1
Show InChI InChI=1S/C19H21F3N2O5S/c1-27-15-7-14(8-16(10-15)28-2)24-13-5-6-18(17(9-13)29-19(20,21)22)30(25,26)23-11-12-3-4-12/h5-10,12,23-24H,3-4,11H2,1-2H3
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37n/a 72n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242435
PNG
(US9422235, 9)
Show SMILES FC(F)(F)c1cc(Nc2ccc(Cl)cc2Cl)ccc1S(=O)(=O)NCC1CCCO1
Show InChI InChI=1S/C18H17Cl2F3N2O3S/c19-11-3-5-16(15(20)8-11)25-12-4-6-17(14(9-12)18(21,22)23)29(26,27)24-10-13-2-1-7-28-13/h3-6,8-9,13,24-25H,1-2,7,10H2
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38n/a 84n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242492
PNG
(US9422235, 73)
Show SMILES FC(F)(F)c1cc(Nc2cccnc2Cl)ccc1S(=O)(=O)NCC1CC1
Show InChI InChI=1S/C16H15ClF3N3O2S/c17-15-13(2-1-7-21-15)23-11-5-6-14(12(8-11)16(18,19)20)26(24,25)22-9-10-3-4-10/h1-2,5-8,10,22-23H,3-4,9H2
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43.3n/a 95.6n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242520
PNG
(US9422235, 105)
Show SMILES FC(F)(F)c1cc(NN2CCCCCC2)ccc1S(=O)(=O)NCC1CC1
Show InChI InChI=1S/C17H24F3N3O2S/c18-17(19,20)15-11-14(22-23-9-3-1-2-4-10-23)7-8-16(15)26(24,25)21-12-13-5-6-13/h7-8,11,13,21-22H,1-6,9-10,12H2
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49n/a 83.4n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242460
PNG
(US9422235, 36)
Show SMILES Fc1ccc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCC2CC2)c(F)c1
Show InChI InChI=1S/C17H15F5N2O2S/c18-11-3-5-15(14(19)7-11)24-12-4-6-16(13(8-12)17(20,21)22)27(25,26)23-9-10-1-2-10/h3-8,10,23-24H,1-2,9H2
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53n/a 106n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242505
PNG
(US9422235, 88)
Show SMILES FC(F)(F)c1cc(NC2CCCCCCC2)ccc1S(=O)(=O)NCC1CC1
Show InChI InChI=1S/C19H27F3N2O2S/c20-19(21,22)17-12-16(24-15-6-4-2-1-3-5-7-15)10-11-18(17)27(25,26)23-13-14-8-9-14/h10-12,14-15,23-24H,1-9,13H2
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56n/a 91n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242523
PNG
(US9422235, 108)
Show SMILES CC(C)(NS(=O)(=O)c1ccc(NC2CCCCC2)cc1C(F)(F)F)C1CC1
Show InChI InChI=1S/C19H27F3N2O2S/c1-18(2,13-8-9-13)24-27(25,26)17-11-10-15(12-16(17)19(20,21)22)23-14-6-4-3-5-7-14/h10-14,23-24H,3-9H2,1-2H3
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58n/a 95n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242468
PNG
(US9422235, 44)
Show SMILES COc1ccc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCC2CC2)c(OC)c1
Show InChI InChI=1S/C19H21F3N2O4S/c1-27-14-6-7-16(17(10-14)28-2)24-13-5-8-18(15(9-13)19(20,21)22)29(25,26)23-11-12-3-4-12/h5-10,12,23-24H,3-4,11H2,1-2H3
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Pharmos Corporation

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Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242460
PNG
(US9422235, 36)
Show SMILES Fc1ccc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCC2CC2)c(F)c1
Show InChI InChI=1S/C17H15F5N2O2S/c18-11-3-5-15(14(19)7-11)24-12-4-6-16(13(8-12)17(20,21)22)27(25,26)23-9-10-1-2-10/h3-8,10,23-24H,1-2,9H2
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Pharmos Corporation

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Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242460
PNG
(US9422235, 36)
Show SMILES Fc1ccc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCC2CC2)c(F)c1
Show InChI InChI=1S/C17H15F5N2O2S/c18-11-3-5-15(14(19)7-11)24-12-4-6-16(13(8-12)17(20,21)22)27(25,26)23-9-10-1-2-10/h3-8,10,23-24H,1-2,9H2
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Pharmos Corporation

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Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242493
PNG
(US9422235, 74)
Show SMILES CC(C)(NS(=O)(=O)c1ccc(NC2CC3CCC2C3)cc1C(F)(F)F)C1CC1
Show InChI InChI=1S/C20H27F3N2O2S/c1-19(2,14-5-6-14)25-28(26,27)18-8-7-15(11-16(18)20(21,22)23)24-17-10-12-3-4-13(17)9-12/h7-8,11-14,17,24-25H,3-6,9-10H2,1-2H3
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Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242471
PNG
(US9422235, 47)
Show SMILES FC(F)(F)c1cc(Nc2ccc3OCCOc3c2)ccc1S(=O)(=O)NCC1CC1
Show InChI InChI=1S/C19H19F3N2O4S/c20-19(21,22)15-9-13(4-6-18(15)29(25,26)23-11-12-1-2-12)24-14-3-5-16-17(10-14)28-8-7-27-16/h3-6,9-10,12,23-24H,1-2,7-8,11H2
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Pharmos Corporation

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Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242509
PNG
(US9422235, 92 | US9422235, 96)
Show SMILES FC(F)(F)c1cc(NC2CCCCC2)ccc1S(=O)(=O)NCC1CC1
Show InChI InChI=1S/C17H23F3N2O2S/c18-17(19,20)15-10-14(22-13-4-2-1-3-5-13)8-9-16(15)25(23,24)21-11-12-6-7-12/h8-10,12-13,21-22H,1-7,11H2
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Pharmos Corporation

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Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242509
PNG
(US9422235, 92 | US9422235, 96)
Show SMILES FC(F)(F)c1cc(NC2CCCCC2)ccc1S(=O)(=O)NCC1CC1
Show InChI InChI=1S/C17H23F3N2O2S/c18-17(19,20)15-10-14(22-13-4-2-1-3-5-13)8-9-16(15)25(23,24)21-11-12-6-7-12/h8-10,12-13,21-22H,1-7,11H2
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Pharmos Corporation

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Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242445
PNG
(US9422235, 21)
Show SMILES COc1cc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCC2CCCO2)cc(OC)c1
Show InChI InChI=1S/C20H23F3N2O5S/c1-28-16-8-14(9-17(11-16)29-2)25-13-5-6-19(18(10-13)20(21,22)23)31(26,27)24-12-15-4-3-7-30-15/h5-6,8-11,15,24-25H,3-4,7,12H2,1-2H3
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Pharmos Corporation

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Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242456
PNG
(US9422235, 32)
Show SMILES CCCN(CC1CC1)c1ccc(c(c1)C(F)(F)F)S(=O)(=O)NCC1CCCO1
Show InChI InChI=1S/C19H27F3N2O3S/c1-2-9-24(13-14-5-6-14)15-7-8-18(17(11-15)19(20,21)22)28(25,26)23-12-16-4-3-10-27-16/h7-8,11,14,16,23H,2-6,9-10,12-13H2,1H3
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Pharmos Corporation

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Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242433
PNG
(US9422235, 6)
Show SMILES COc1ccc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCC2CC2)cc1
Show InChI InChI=1S/C18H19F3N2O3S/c1-26-15-7-4-13(5-8-15)23-14-6-9-17(16(10-14)18(19,20)21)27(24,25)22-11-12-2-3-12/h4-10,12,22-23H,2-3,11H2,1H3
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Pharmos Corporation

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Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242511
PNG
(US9422235, 94)
Show SMILES FC(F)(F)c1cc(NN2CCCCC2)ccc1S(=O)(=O)NCC1CC1
Show InChI InChI=1S/C16H22F3N3O2S/c17-16(18,19)14-10-13(21-22-8-2-1-3-9-22)6-7-15(14)25(23,24)20-11-12-4-5-12/h6-7,10,12,20-21H,1-5,8-9,11H2
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Pharmos Corporation

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Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242459
PNG
(US9422235, 35)
Show SMILES FC(F)(F)c1cc(Nc2ccc(Cl)cc2Cl)ccc1S(=O)(=O)NCC1CCOCC1
Show InChI InChI=1S/C19H19Cl2F3N2O3S/c20-13-1-3-17(16(21)9-13)26-14-2-4-18(15(10-14)19(22,23)24)30(27,28)25-11-12-5-7-29-8-6-12/h1-4,9-10,12,25-26H,5-8,11H2
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Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242434
PNG
(US9422235, 7)
Show SMILES FC(F)(F)c1cc(Nc2ccccc2)ccc1S(=O)(=O)NCC1CC1
Show InChI InChI=1S/C17H17F3N2O2S/c18-17(19,20)15-10-14(22-13-4-2-1-3-5-13)8-9-16(15)25(23,24)21-11-12-6-7-12/h1-5,8-10,12,21-22H,6-7,11H2
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Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242438
PNG
(US9422235, 12)
Show SMILES COc1cc(Nc2ccc(cc2)S(=O)(=O)NCC2CC2)cc(OC)c1
Show InChI InChI=1S/C18H22N2O4S/c1-23-16-9-15(10-17(11-16)24-2)20-14-5-7-18(8-6-14)25(21,22)19-12-13-3-4-13/h5-11,13,19-20H,3-4,12H2,1-2H3
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Pharmos Corporation

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Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242452
PNG
(US9422235, 28)
Show SMILES COc1cc(Nc2cc(Cl)c(c(Cl)c2)S(=O)(=O)NCC2CCCO2)cc(OC)c1
Show InChI InChI=1S/C19H22Cl2N2O5S/c1-26-15-6-12(7-16(10-15)27-2)23-13-8-17(20)19(18(21)9-13)29(24,25)22-11-14-4-3-5-28-14/h6-10,14,22-23H,3-5,11H2,1-2H3
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Pharmos Corporation

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Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242443
PNG
(US9422235, 19)
Show SMILES COc1cc(Nc2cc(F)c(cc2F)S(=O)(=O)NCC2CCCO2)cc(OC)c1
Show InChI InChI=1S/C19H22F2N2O5S/c1-26-14-6-12(7-15(8-14)27-2)23-18-9-17(21)19(10-16(18)20)29(24,25)22-11-13-4-3-5-28-13/h6-10,13,22-23H,3-5,11H2,1-2H3
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Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242522
PNG
(US9422235, 107)
Show SMILES CC(C)(NS(=O)(=O)c1ccc(NN2CCCCC2)cc1C(F)(F)F)C1CC1
Show InChI InChI=1S/C18H26F3N3O2S/c1-17(2,13-6-7-13)23-27(25,26)16-9-8-14(12-15(16)18(19,20)21)22-24-10-4-3-5-11-24/h8-9,12-13,22-23H,3-7,10-11H2,1-2H3
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Pharmos Corporation

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Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242460
PNG
(US9422235, 36)
Show SMILES Fc1ccc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCC2CC2)c(F)c1
Show InChI InChI=1S/C17H15F5N2O2S/c18-11-3-5-15(14(19)7-11)24-12-4-6-16(13(8-12)17(20,21)22)27(25,26)23-9-10-1-2-10/h3-8,10,23-24H,1-2,9H2
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Pharmos Corporation

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Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242466
PNG
(US9422235, 42)
Show SMILES FC(F)(F)c1cc(NC2CC3CCC2C3)ccc1S(=O)(=O)NCc1ccco1
Show InChI InChI=1S/C19H21F3N2O3S/c20-19(21,22)16-10-14(24-17-9-12-3-4-13(17)8-12)5-6-18(16)28(25,26)23-11-15-2-1-7-27-15/h1-2,5-7,10,12-13,17,23-24H,3-4,8-9,11H2
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Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242446
PNG
(US9422235, 22)
Show SMILES COc1cc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCc2ccncc2)cc(OC)c1
Show InChI InChI=1S/C21H20F3N3O4S/c1-30-17-9-16(10-18(12-17)31-2)27-15-3-4-20(19(11-15)21(22,23)24)32(28,29)26-13-14-5-7-25-8-6-14/h3-12,26-27H,13H2,1-2H3
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Pharmos Corporation

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Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242453
PNG
(US9422235, 29)
Show SMILES COc1cc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCc2ccco2)cc(OC)c1
Show InChI InChI=1S/C20H19F3N2O5S/c1-28-16-8-14(9-17(11-16)29-2)25-13-5-6-19(18(10-13)20(21,22)23)31(26,27)24-12-15-4-3-7-30-15/h3-11,24-25H,12H2,1-2H3
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Pharmos Corporation

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Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242521
PNG
(US9422235, 106)
Show SMILES CC(C)(NS(=O)(=O)c1ccc(NN2CCCCCC2)cc1C(F)(F)F)C1CC1
Show InChI InChI=1S/C19H28F3N3O2S/c1-18(2,14-7-8-14)24-28(26,27)17-10-9-15(13-16(17)19(20,21)22)23-25-11-5-3-4-6-12-25/h9-10,13-14,23-24H,3-8,11-12H2,1-2H3
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Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242436
PNG
(US9422235, 10)
Show SMILES CCCCNS(=O)(=O)c1ccc(Nc2ccc(Cl)cc2Cl)cc1C(F)(F)F
Show InChI InChI=1S/C17H17Cl2F3N2O2S/c1-2-3-8-23-27(25,26)16-7-5-12(10-13(16)17(20,21)22)24-15-6-4-11(18)9-14(15)19/h4-7,9-10,23-24H,2-3,8H2,1H3
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Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242479
PNG
(US9422235, 57)
Show SMILES CN(CC1CC1)S(=O)(=O)c1ccc(Nc2ccc(Cl)cc2Cl)cc1C(F)(F)F
Show InChI InChI=1S/C18H17Cl2F3N2O2S/c1-25(10-11-2-3-11)28(26,27)17-7-5-13(9-14(17)18(21,22)23)24-16-6-4-12(19)8-15(16)20/h4-9,11,24H,2-3,10H2,1H3
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175n/a 327n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM242430
PNG
(US9422235, 3)
Show SMILES FC(F)(F)c1cc(Nc2ccc(Cl)cc2Cl)ccc1S(=O)(=O)NCC1CC1
Show InChI InChI=1S/C17H15Cl2F3N2O2S/c18-11-3-5-15(14(19)7-11)24-12-4-6-16(13(8-12)17(20,21)22)27(25,26)23-9-10-1-2-10/h3-8,10,23-24H,1-2,9H2
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Pharmos Corporation

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Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242503
PNG
(US9422235, 86)
Show SMILES CC(=O)N(CC1CC1)S(=O)(=O)c1ccc(NC2CC3CCC2C3)cc1C(F)(F)F
Show InChI InChI=1S/C20H25F3N2O3S/c1-12(26)25(11-13-2-3-13)29(27,28)19-7-6-16(10-17(19)20(21,22)23)24-18-9-14-4-5-15(18)8-14/h6-7,10,13-15,18,24H,2-5,8-9,11H2,1H3
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Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242478
PNG
(US9422235, 56)
Show SMILES FC(F)(F)c1cc(Nc2ccc(cc2Cl)C#N)ccc1S(=O)(=O)NCC1CCOCC1
Show InChI InChI=1S/C20H19ClF3N3O3S/c21-17-9-14(11-25)1-3-18(17)27-15-2-4-19(16(10-15)20(22,23)24)31(28,29)26-12-13-5-7-30-8-6-13/h1-4,9-10,13,26-27H,5-8,12H2
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Pharmos Corporation

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Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242494
PNG
(US9422235, 75)
Show SMILES COc1cc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NC(C)(C)C2CC2)cc(OC)c1
Show InChI InChI=1S/C21H25F3N2O4S/c1-20(2,13-5-6-13)26-31(27,28)19-8-7-14(11-18(19)21(22,23)24)25-15-9-16(29-3)12-17(10-15)30-4/h7-13,25-26H,5-6H2,1-4H3
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Pharmos Corporation

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Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242449
PNG
(US9422235, 25)
Show SMILES FC(F)(F)c1cc(NC2CCCCC2)ccc1S(=O)(=O)NCC1CCCO1
Show InChI InChI=1S/C18H25F3N2O3S/c19-18(20,21)16-11-14(23-13-5-2-1-3-6-13)8-9-17(16)27(24,25)22-12-15-7-4-10-26-15/h8-9,11,13,15,22-23H,1-7,10,12H2
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Pharmos Corporation

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Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242507
PNG
(US9422235, 90)
Show SMILES CC1CCC(CC1)Nc1ccc(c(c1)C(F)(F)F)S(=O)(=O)NCC1CC1
Show InChI InChI=1S/C18H25F3N2O2S/c1-12-2-6-14(7-3-12)23-15-8-9-17(16(10-15)18(19,20)21)26(24,25)22-11-13-4-5-13/h8-10,12-14,22-23H,2-7,11H2,1H3
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Pharmos Corporation

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Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242472
PNG
(US9422235, 48)
Show SMILES CC1(C)C2CC1C(CNc1ccc(c(c1)C(F)(F)F)S(=O)(=O)NCC1CC1)CC2
Show InChI InChI=1S/C21H29F3N2O2S/c1-20(2)15-6-5-14(17(20)9-15)12-25-16-7-8-19(18(10-16)21(22,23)24)29(27,28)26-11-13-3-4-13/h7-8,10,13-15,17,25-26H,3-6,9,11-12H2,1-2H3
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Pharmos Corporation

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Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242524
PNG
(US9422235, 109)
Show SMILES FC(F)(F)c1cc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCC2CC2)ccc1C#N
Show InChI InChI=1S/C19H15F6N3O2S/c20-18(21,22)15-7-13(4-3-12(15)9-26)28-14-5-6-17(16(8-14)19(23,24)25)31(29,30)27-10-11-1-2-11/h3-8,11,27-28H,1-2,10H2
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Pharmos Corporation

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Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242495
PNG
(US9422235, 76)
Show SMILES CC(C)(NS(=O)(=O)c1ccc(Nc2cccnc2Cl)cc1C(F)(F)F)C1CC1
Show InChI InChI=1S/C18H19ClF3N3O2S/c1-17(2,11-5-6-11)25-28(26,27)15-8-7-12(10-13(15)18(20,21)22)24-14-4-3-9-23-16(14)19/h3-4,7-11,24-25H,5-6H2,1-2H3
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Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242440
PNG
(US9422235, 16)
Show SMILES COc1cc(OC)nc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCC2CC2)n1
Show InChI InChI=1S/C17H19F3N4O4S/c1-27-14-8-15(28-2)24-16(23-14)22-11-5-6-13(12(7-11)17(18,19)20)29(25,26)21-9-10-3-4-10/h5-8,10,21H,3-4,9H2,1-2H3,(H,22,23,24)
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Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242476
PNG
(US9422235, 54)
Show SMILES COc1cc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCC2CCOCC2)cc(OC)c1
Show InChI InChI=1S/C21H25F3N2O5S/c1-29-17-9-16(10-18(12-17)30-2)26-15-3-4-20(19(11-15)21(22,23)24)32(27,28)25-13-14-5-7-31-8-6-14/h3-4,9-12,14,25-26H,5-8,13H2,1-2H3
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Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242514
PNG
(US9422235, 98)
Show SMILES CCCN(CC1CC1)c1ccc(c(c1)C(F)(F)F)S(=O)(=O)NCC1CC1
Show InChI InChI=1S/C18H25F3N2O2S/c1-2-9-23(12-14-5-6-14)15-7-8-17(16(10-15)18(19,20)21)26(24,25)22-11-13-3-4-13/h7-8,10,13-14,22H,2-6,9,11-12H2,1H3
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Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM242480
PNG
(US9422235, 58)
Show SMILES FC(F)(F)c1cc(NC2CC3CCC2C3)ccc1S(=O)(=O)NCC1CC1
Show InChI InChI=1S/C18H23F3N2O2S/c19-18(20,21)15-9-14(23-16-8-12-3-4-13(16)7-12)5-6-17(15)26(24,25)22-10-11-1-2-11/h5-6,9,11-13,16,22-23H,1-4,7-8,10H2
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Pharmos Corporation

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Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242502
PNG
(US9422235, 85)
Show SMILES FC(F)(F)c1cc(NC2CC3CCC2C3)ccc1S(=O)(=O)NOCC1CC1
Show InChI InChI=1S/C18H23F3N2O3S/c19-18(20,21)15-9-14(22-16-8-12-3-4-13(16)7-12)5-6-17(15)27(24,25)23-26-10-11-1-2-11/h5-6,9,11-13,16,22-23H,1-4,7-8,10H2
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Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM242431
PNG
(US9422235, 4)
Show SMILES COc1cc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCC2CC2)cc(OC)c1
Show InChI InChI=1S/C19H21F3N2O4S/c1-27-15-7-14(8-16(10-15)28-2)24-13-5-6-18(17(9-13)19(20,21)22)29(25,26)23-11-12-3-4-12/h5-10,12,23-24H,3-4,11H2,1-2H3
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Pharmos Corporation

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Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242485
PNG
(US9422235, 66)
Show SMILES CC(C)(NS(=O)(=O)c1ccc(Nc2ccc(Cl)cc2Cl)cc1C(F)(F)F)C1CC1
Show InChI InChI=1S/C19H19Cl2F3N2O2S/c1-18(2,11-3-4-11)26-29(27,28)17-8-6-13(10-14(17)19(22,23)24)25-16-7-5-12(20)9-15(16)21/h5-11,25-26H,3-4H2,1-2H3
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Pharmos Corporation

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Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242503
PNG
(US9422235, 86)
Show SMILES CC(=O)N(CC1CC1)S(=O)(=O)c1ccc(NC2CC3CCC2C3)cc1C(F)(F)F
Show InChI InChI=1S/C20H25F3N2O3S/c1-12(26)25(11-13-2-3-13)29(27,28)19-7-6-16(10-17(19)20(21,22)23)24-18-9-14-4-5-15(18)8-14/h6-7,10,13-15,18,24H,2-5,8-9,11H2,1H3
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Pharmos Corporation

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Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242507
PNG
(US9422235, 90)
Show SMILES CC1CCC(CC1)Nc1ccc(c(c1)C(F)(F)F)S(=O)(=O)NCC1CC1
Show InChI InChI=1S/C18H25F3N2O2S/c1-12-2-6-14(7-3-12)23-15-8-9-17(16(10-15)18(19,20)21)26(24,25)22-11-13-4-5-13/h8-10,12-14,22-23H,2-7,11H2,1H3
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Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM242493
PNG
(US9422235, 74)
Show SMILES CC(C)(NS(=O)(=O)c1ccc(NC2CC3CCC2C3)cc1C(F)(F)F)C1CC1
Show InChI InChI=1S/C20H27F3N2O2S/c1-19(2,14-5-6-14)25-28(26,27)18-8-7-15(11-16(18)20(21,22)23)24-17-10-12-3-4-13(17)9-12/h7-8,11-14,17,24-25H,3-6,9-10H2,1-2H3
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Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242509
PNG
(US9422235, 92 | US9422235, 96)
Show SMILES FC(F)(F)c1cc(NC2CCCCC2)ccc1S(=O)(=O)NCC1CC1
Show InChI InChI=1S/C17H23F3N2O2S/c18-17(19,20)15-10-14(22-13-4-2-1-3-5-13)8-9-16(15)25(23,24)21-11-12-6-7-12/h8-10,12-13,21-22H,1-7,11H2
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Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242442
PNG
(US9422235, 18)
Show SMILES COc1cc(Nc2ccc(cc2F)S(=O)(=O)NCC2CCCO2)cc(OC)c1
Show InChI InChI=1S/C19H23FN2O5S/c1-25-15-8-13(9-16(10-15)26-2)22-19-6-5-17(11-18(19)20)28(23,24)21-12-14-4-3-7-27-14/h5-6,8-11,14,21-22H,3-4,7,12H2,1-2H3
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Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242445
PNG
(US9422235, 21)
Show SMILES COc1cc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCC2CCCO2)cc(OC)c1
Show InChI InChI=1S/C20H23F3N2O5S/c1-28-16-8-14(9-17(11-16)29-2)25-13-5-6-19(18(10-13)20(21,22)23)31(26,27)24-12-15-4-3-7-30-15/h5-6,8-11,15,24-25H,3-4,7,12H2,1-2H3
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Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM242465
PNG
(US9422235, 41)
Show SMILES FC(F)(F)c1cc(NC2CC3CCC2C3)ccc1S(=O)(=O)NCC1CCOCC1
Show InChI InChI=1S/C20H27F3N2O3S/c21-20(22,23)17-11-16(25-18-10-14-1-2-15(18)9-14)3-4-19(17)29(26,27)24-12-13-5-7-28-8-6-13/h3-4,11,13-15,18,24-25H,1-2,5-10,12H2
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Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM242520
PNG
(US9422235, 105)
Show SMILES FC(F)(F)c1cc(NN2CCCCCC2)ccc1S(=O)(=O)NCC1CC1
Show InChI InChI=1S/C17H24F3N3O2S/c18-17(19,20)15-11-14(22-23-9-3-1-2-4-10-23)7-8-16(15)26(24,25)21-12-13-5-6-13/h7-8,11,13,21-22H,1-6,9-10,12H2
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Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM242433
PNG
(US9422235, 6)
Show SMILES COc1ccc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCC2CC2)cc1
Show InChI InChI=1S/C18H19F3N2O3S/c1-26-15-7-4-13(5-8-15)23-14-6-9-17(16(10-14)18(19,20)21)27(24,25)22-11-12-2-3-12/h4-10,12,22-23H,2-3,11H2,1H3
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Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242481
PNG
(US9422235, 59)
Show SMILES COc1ccc(Nc2ccc(c(C)c2)S(=O)(=O)NCC2CC2)c(OC)c1
Show InChI InChI=1S/C19H24N2O4S/c1-13-10-15(21-17-8-7-16(24-2)11-18(17)25-3)6-9-19(13)26(22,23)20-12-14-4-5-14/h6-11,14,20-21H,4-5,12H2,1-3H3
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Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242438
PNG
(US9422235, 12)
Show SMILES COc1cc(Nc2ccc(cc2)S(=O)(=O)NCC2CC2)cc(OC)c1
Show InChI InChI=1S/C18H22N2O4S/c1-23-16-9-15(10-17(11-16)24-2)20-14-5-7-18(8-6-14)25(21,22)19-12-13-3-4-13/h5-11,13,19-20H,3-4,12H2,1-2H3
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Pharmos Corporation

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Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM242468
PNG
(US9422235, 44)
Show SMILES COc1ccc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCC2CC2)c(OC)c1
Show InChI InChI=1S/C19H21F3N2O4S/c1-27-14-6-7-16(17(10-14)28-2)24-13-5-8-18(15(9-13)19(20,21)22)29(25,26)23-11-12-3-4-12/h5-10,12,23-24H,3-4,11H2,1-2H3
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Pharmos Corporation

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Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242499
PNG
(US9422235, 80)
Show SMILES FC(F)(F)c1cc(NC2CN3CCC2CC3)ccc1S(=O)(=O)NCC1CC1
Show InChI InChI=1S/C18H24F3N3O2S/c19-18(20,21)15-9-14(23-16-11-24-7-5-13(16)6-8-24)3-4-17(15)27(25,26)22-10-12-1-2-12/h3-4,9,12-13,16,22-23H,1-2,5-8,10-11H2
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Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242518
PNG
(US9422235, 103)
Show SMILES FC(F)(F)c1cc(NN2CCOCC2)ccc1S(=O)(=O)NCC1CC1
Show InChI InChI=1S/C15H20F3N3O3S/c16-15(17,18)13-9-12(20-21-5-7-24-8-6-21)3-4-14(13)25(22,23)19-10-11-1-2-11/h3-4,9,11,19-20H,1-2,5-8,10H2
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Pharmos Corporation

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Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM242431
PNG
(US9422235, 4)
Show SMILES COc1cc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCC2CC2)cc(OC)c1
Show InChI InChI=1S/C19H21F3N2O4S/c1-27-15-7-14(8-16(10-15)28-2)24-13-5-6-18(17(9-13)19(20,21)22)29(25,26)23-11-12-3-4-12/h5-10,12,23-24H,3-4,11H2,1-2H3
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Pharmos Corporation

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Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242475
PNG
(US9422235, 53)
Show SMILES CCCN(CC1CC1)c1ccc(c(c1)C(F)(F)F)S(=O)(=O)NCC1CCOCC1
Show InChI InChI=1S/C20H29F3N2O3S/c1-2-9-25(14-16-3-4-16)17-5-6-19(18(12-17)20(21,22)23)29(26,27)24-13-15-7-10-28-11-8-15/h5-6,12,15-16,24H,2-4,7-11,13-14H2,1H3
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Pharmos Corporation

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Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242447
PNG
(US9422235, 23)
Show SMILES COc1cc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)N2CCOCC2)cc(OC)c1
Show InChI InChI=1S/C19H21F3N2O5S/c1-27-15-9-14(10-16(12-15)28-2)23-13-3-4-18(17(11-13)19(20,21)22)30(25,26)24-5-7-29-8-6-24/h3-4,9-12,23H,5-8H2,1-2H3
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Pharmos Corporation

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Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242441
PNG
(US9422235, 17)
Show SMILES COc1cc(Nc2ccc(c(F)c2)S(=O)(=O)NCC2CCCO2)cc(OC)c1
Show InChI InChI=1S/C19H23FN2O5S/c1-25-16-8-14(9-17(11-16)26-2)22-13-5-6-19(18(20)10-13)28(23,24)21-12-15-4-3-7-27-15/h5-6,8-11,15,21-22H,3-4,7,12H2,1-2H3
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Pharmos Corporation

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Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242495
PNG
(US9422235, 76)
Show SMILES CC(C)(NS(=O)(=O)c1ccc(Nc2cccnc2Cl)cc1C(F)(F)F)C1CC1
Show InChI InChI=1S/C18H19ClF3N3O2S/c1-17(2,11-5-6-11)25-28(26,27)15-8-7-12(10-13(15)18(20,21)22)24-14-4-3-9-23-16(14)19/h3-4,7-11,24-25H,5-6H2,1-2H3
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Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM242452
PNG
(US9422235, 28)
Show SMILES COc1cc(Nc2cc(Cl)c(c(Cl)c2)S(=O)(=O)NCC2CCCO2)cc(OC)c1
Show InChI InChI=1S/C19H22Cl2N2O5S/c1-26-15-6-12(7-16(10-15)27-2)23-13-8-17(20)19(18(21)9-13)29(24,25)22-11-14-4-3-5-28-14/h6-10,14,22-23H,3-5,11H2,1-2H3
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Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242437
PNG
(US9422235, 11)
Show SMILES COc1cc(Nc2ccc(c(OC(F)(F)F)c2)S(=O)(=O)NCC2CC2)cc(OC)c1
Show InChI InChI=1S/C19H21F3N2O5S/c1-27-15-7-14(8-16(10-15)28-2)24-13-5-6-18(17(9-13)29-19(20,21)22)30(25,26)23-11-12-3-4-12/h5-10,12,23-24H,3-4,11H2,1-2H3
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Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242461
PNG
(US9422235, 37 | US9422235, 38)
Show SMILES Fc1ccc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCc2ccco2)c(F)c1
Show InChI InChI=1S/C18H13F5N2O3S/c19-11-3-5-16(15(20)8-11)25-12-4-6-17(14(9-12)18(21,22)23)29(26,27)24-10-13-2-1-7-28-13/h1-9,24-25H,10H2
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Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242481
PNG
(US9422235, 59)
Show SMILES COc1ccc(Nc2ccc(c(C)c2)S(=O)(=O)NCC2CC2)c(OC)c1
Show InChI InChI=1S/C19H24N2O4S/c1-13-10-15(21-17-8-7-16(24-2)11-18(17)25-3)6-9-19(13)26(22,23)20-12-14-4-5-14/h6-11,14,20-21H,4-5,12H2,1-3H3
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Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242498
PNG
(US9422235, 79)
Show SMILES OC(=O)c1ccc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCC2CC2)c(Cl)c1
Show InChI InChI=1S/C18H16ClF3N2O4S/c19-14-7-11(17(25)26)3-5-15(14)24-12-4-6-16(13(8-12)18(20,21)22)29(27,28)23-9-10-1-2-10/h3-8,10,23-24H,1-2,9H2,(H,25,26)
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Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242497
PNG
(US9422235, 78)
Show SMILES COC(=O)c1ccc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCC2CC2)c(Cl)c1
Show InChI InChI=1S/C19H18ClF3N2O4S/c1-29-18(26)12-4-6-16(15(20)8-12)25-13-5-7-17(14(9-13)19(21,22)23)30(27,28)24-10-11-2-3-11/h4-9,11,24-25H,2-3,10H2,1H3
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Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242439
PNG
(US9422235, 15)
Show SMILES Fc1ccc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCC2CCCO2)c(F)c1
Show InChI InChI=1S/C18H17F5N2O3S/c19-11-3-5-16(15(20)8-11)25-12-4-6-17(14(9-12)18(21,22)23)29(26,27)24-10-13-2-1-7-28-13/h3-6,8-9,13,24-25H,1-2,7,10H2
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629n/a 1.64E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242488
PNG
(US9422235, 69)
Show SMILES CC(=O)N1CCc2ccc(Nc3ccc(c(c3)C(F)(F)F)S(=O)(=O)NCC3CC3)cc12
Show InChI InChI=1S/C21H22F3N3O3S/c1-13(28)27-9-8-15-4-5-17(11-19(15)27)26-16-6-7-20(18(10-16)21(22,23)24)31(29,30)25-12-14-2-3-14/h4-7,10-11,14,25-26H,2-3,8-9,12H2,1H3
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Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242500
PNG
(US9422235, 82)
Show SMILES CC(C)(NS(=O)(=O)c1ccc(Nc2ccc(cc2Cl)C(O)=O)cc1C(F)(F)F)C1CC1
Show InChI InChI=1S/C20H20ClF3N2O4S/c1-19(2,12-4-5-12)26-31(29,30)17-8-6-13(10-14(17)20(22,23)24)25-16-7-3-11(18(27)28)9-15(16)21/h3,6-10,12,25-26H,4-5H2,1-2H3,(H,27,28)
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Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242502
PNG
(US9422235, 85)
Show SMILES FC(F)(F)c1cc(NC2CC3CCC2C3)ccc1S(=O)(=O)NOCC1CC1
Show InChI InChI=1S/C18H23F3N2O3S/c19-18(20,21)15-9-14(22-16-8-12-3-4-13(16)7-12)5-6-17(15)27(24,25)23-26-10-11-1-2-11/h5-6,9,11-13,16,22-23H,1-4,7-8,10H2
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Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242451
PNG
(US9422235, 27)
Show SMILES COc1cc(Nc2ccc(c(Cl)c2)S(=O)(=O)NCC2CCCO2)cc(OC)c1
Show InChI InChI=1S/C19H23ClN2O5S/c1-25-16-8-14(9-17(11-16)26-2)22-13-5-6-19(18(20)10-13)28(23,24)21-12-15-4-3-7-27-15/h5-6,8-11,15,21-22H,3-4,7,12H2,1-2H3
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682n/a 1.44E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM242445
PNG
(US9422235, 21)
Show SMILES COc1cc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCC2CCCO2)cc(OC)c1
Show InChI InChI=1S/C20H23F3N2O5S/c1-28-16-8-14(9-17(11-16)29-2)25-13-5-6-19(18(10-13)20(21,22)23)31(26,27)24-12-15-4-3-7-30-15/h5-6,8-11,15,24-25H,3-4,7,12H2,1-2H3
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735n/a 1.64E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242516
PNG
(US9422235, 100)
Show SMILES FC(F)(F)c1cc(NCc2ccccn2)ccc1S(=O)(=O)NCC1CC1
Show InChI InChI=1S/C17H18F3N3O2S/c18-17(19,20)15-9-13(22-11-14-3-1-2-8-21-14)6-7-16(15)26(24,25)23-10-12-4-5-12/h1-3,6-9,12,22-23H,4-5,10-11H2
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789n/a 1.37E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242463
PNG
(US9422235, 39)
Show SMILES Fc1ccc(Nc2ccc(cc2)S(=O)(=O)NCC2CC2)c(F)c1
Show InChI InChI=1S/C16H16F2N2O2S/c17-12-3-8-16(15(18)9-12)20-13-4-6-14(7-5-13)23(21,22)19-10-11-1-2-11/h3-9,11,19-20H,1-2,10H2
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800n/a 1.90E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM242468
PNG
(US9422235, 44)
Show SMILES COc1ccc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCC2CC2)c(OC)c1
Show InChI InChI=1S/C19H21F3N2O4S/c1-27-14-6-7-16(17(10-14)28-2)24-13-5-8-18(15(9-13)19(20,21)22)29(25,26)23-11-12-3-4-12/h5-10,12,23-24H,3-4,11H2,1-2H3
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813n/a 1.42E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242464
PNG
(US9422235, 40)
Show SMILES O=S(=O)(NCC1CC1)c1ccc(NC2CC3CCC2C3)cc1
Show InChI InChI=1S/C17H24N2O2S/c20-22(21,18-11-12-1-2-12)16-7-5-15(6-8-16)19-17-10-13-3-4-14(17)9-13/h5-8,12-14,17-19H,1-4,9-11H2
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818n/a 1.94E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242460
PNG
(US9422235, 36)
Show SMILES Fc1ccc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCC2CC2)c(F)c1
Show InChI InChI=1S/C17H15F5N2O2S/c18-11-3-5-15(14(19)7-11)24-12-4-6-16(13(8-12)17(20,21)22)27(25,26)23-9-10-1-2-10/h3-8,10,23-24H,1-2,9H2
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822n/a 1.93E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242470
PNG
(US9422235, 46)
Show SMILES FC(F)(F)c1cc(Nc2ccc(cc2)N2CCOCC2)ccc1S(=O)(=O)NCC1CC1
Show InChI InChI=1S/C21H24F3N3O3S/c22-21(23,24)19-13-17(5-8-20(19)31(28,29)25-14-15-1-2-15)26-16-3-6-18(7-4-16)27-9-11-30-12-10-27/h3-8,13,15,25-26H,1-2,9-12,14H2
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825n/a 2.15E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242432
PNG
(US9422235, 5)
Show SMILES Fc1cc(Nc2ccc(Cl)cc2Cl)ccc1C(=O)NCC1CC1
Show InChI InChI=1S/C17H15Cl2FN2O/c18-11-3-6-16(14(19)7-11)22-12-4-5-13(15(20)8-12)17(23)21-9-10-1-2-10/h3-8,10,22H,1-2,9H2,(H,21,23)
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826n/a 2.15E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242457
PNG
(US9422235, 33)
Show SMILES COc1cc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)N2CCc3ccccc23)cc(OC)c1
Show InChI InChI=1S/C23H21F3N2O4S/c1-31-18-11-17(12-19(14-18)32-2)27-16-7-8-22(20(13-16)23(24,25)26)33(29,30)28-10-9-15-5-3-4-6-21(15)28/h3-8,11-14,27H,9-10H2,1-2H3
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880n/a 2.08E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM242441
PNG
(US9422235, 17)
Show SMILES COc1cc(Nc2ccc(c(F)c2)S(=O)(=O)NCC2CCCO2)cc(OC)c1
Show InChI InChI=1S/C19H23FN2O5S/c1-25-16-8-14(9-17(11-16)26-2)22-13-5-6-19(18(20)10-13)28(23,24)21-12-15-4-3-7-27-15/h5-6,8-11,15,21-22H,3-4,7,12H2,1-2H3
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889n/a 2.00E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242515
PNG
(US9422235, 99)
Show SMILES COCCCNc1ccc(c(c1)C(F)(F)F)S(=O)(=O)NCC1CC1
Show InChI InChI=1S/C15H21F3N2O3S/c1-23-8-2-7-19-12-5-6-14(13(9-12)15(16,17)18)24(21,22)20-10-11-3-4-11/h5-6,9,11,19-20H,2-4,7-8,10H2,1H3
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919n/a 1.60E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM242505
PNG
(US9422235, 88)
Show SMILES FC(F)(F)c1cc(NC2CCCCCCC2)ccc1S(=O)(=O)NCC1CC1
Show InChI InChI=1S/C19H27F3N2O2S/c20-19(21,22)17-12-16(24-15-6-4-2-1-3-5-7-15)10-11-18(17)27(25,26)23-13-14-8-9-14/h10-12,14-15,23-24H,1-9,13H2
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930n/a 1.67E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242429
PNG
(US9422235, 1)
Show SMILES FC(F)(F)c1cc(Nc2ccc(Cl)cc2Cl)ccc1S(=O)(=O)NCCN1CCOCC1
Show InChI InChI=1S/C19H20Cl2F3N3O3S/c20-13-1-3-17(16(21)11-13)26-14-2-4-18(15(12-14)19(22,23)24)31(28,29)25-5-6-27-7-9-30-10-8-27/h1-4,11-12,25-26H,5-10H2
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933n/a 1.84E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242510
PNG
(US9422235, 93)
Show SMILES FC(F)(F)c1cc(NCC2CCOCC2)ccc1S(=O)(=O)NCC1CC1
Show InChI InChI=1S/C17H23F3N2O3S/c18-17(19,20)15-9-14(21-10-13-5-7-25-8-6-13)3-4-16(15)26(23,24)22-11-12-1-2-12/h3-4,9,12-13,21-22H,1-2,5-8,10-11H2
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996n/a 1.72E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242469
PNG
(US9422235, 45)
Show SMILES CCCN(CC1CC1)S(=O)(=O)c1ccc(Nc2ccc(OC)cc2OC)cc1C(F)(F)F
Show InChI InChI=1S/C22H27F3N2O4S/c1-4-11-27(14-15-5-6-15)32(28,29)21-10-7-16(12-18(21)22(23,24)25)26-19-9-8-17(30-2)13-20(19)31-3/h7-10,12-13,15,26H,4-6,11,14H2,1-3H3
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999n/a 1.75E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM242435
PNG
(US9422235, 9)
Show SMILES FC(F)(F)c1cc(Nc2ccc(Cl)cc2Cl)ccc1S(=O)(=O)NCC1CCCO1
Show InChI InChI=1S/C18H17Cl2F3N2O3S/c19-11-3-5-16(15(20)8-11)25-12-4-6-17(14(9-12)18(21,22)23)29(26,27)24-10-13-2-1-7-28-13/h3-6,8-9,13,24-25H,1-2,7,10H2
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1.03E+3n/a 2.30E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242506
PNG
(US9422235, 89)
Show SMILES CC(C)(C)C1CCC(CC1)Nc1ccc(c(c1)C(F)(F)F)S(=O)(=O)NCC1CC1
Show InChI InChI=1S/C21H31F3N2O2S/c1-20(2,3)15-6-8-16(9-7-15)26-17-10-11-19(18(12-17)21(22,23)24)29(27,28)25-13-14-4-5-14/h10-12,14-16,25-26H,4-9,13H2,1-3H3
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1.07E+3n/a 1.89E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242496
PNG
(US9422235, 77)
Show SMILES FC(F)(F)c1cc(Nc2ccc(Cl)cc2Cl)ccc1S(=O)(=O)NOCC1CC1
Show InChI InChI=1S/C17H15Cl2F3N2O3S/c18-11-3-5-15(14(19)7-11)23-12-4-6-16(13(8-12)17(20,21)22)28(25,26)24-27-9-10-1-2-10/h3-8,10,23-24H,1-2,9H2
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1.15E+3n/a 2.26E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM242431
PNG
(US9422235, 4)
Show SMILES COc1cc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCC2CC2)cc(OC)c1
Show InChI InChI=1S/C19H21F3N2O4S/c1-27-15-7-14(8-16(10-15)28-2)24-13-5-6-18(17(9-13)19(20,21)22)29(25,26)23-11-12-3-4-12/h5-10,12,23-24H,3-4,11H2,1-2H3
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1.16E+3n/a 2.00E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM242434
PNG
(US9422235, 7)
Show SMILES FC(F)(F)c1cc(Nc2ccccc2)ccc1S(=O)(=O)NCC1CC1
Show InChI InChI=1S/C17H17F3N2O2S/c18-17(19,20)15-10-14(22-13-4-2-1-3-5-13)8-9-16(15)25(23,24)21-11-12-6-7-12/h1-5,8-10,12,21-22H,6-7,11H2
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1.16E+3n/a 2.00E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242482
PNG
(US9422235, 61)
Show SMILES NS(=O)(=O)c1ccc(NC2CC3CCC2C3)cc1C(F)(F)F
Show InChI InChI=1S/C14H17F3N2O2S/c15-14(16,17)11-7-10(3-4-13(11)22(18,20)21)19-12-6-8-1-2-9(12)5-8/h3-4,7-9,12,19H,1-2,5-6H2,(H2,18,20,21)
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1.20E+3n/a 2.13E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242455
PNG
(US9422235, 31)
Show SMILES FC(F)(F)c1cc(ccc1S(=O)(=O)NCC1CCCO1)N1CCc2ccccc12
Show InChI InChI=1S/C20H21F3N2O3S/c21-20(22,23)17-12-15(25-10-9-14-4-1-2-6-18(14)25)7-8-19(17)29(26,27)24-13-16-5-3-11-28-16/h1-2,4,6-8,12,16,24H,3,5,9-11,13H2
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1.24E+3n/a 2.78E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM242435
PNG
(US9422235, 9)
Show SMILES FC(F)(F)c1cc(Nc2ccc(Cl)cc2Cl)ccc1S(=O)(=O)NCC1CCCO1
Show InChI InChI=1S/C18H17Cl2F3N2O3S/c19-11-3-5-16(15(20)8-11)25-12-4-6-17(14(9-12)18(21,22)23)29(26,27)24-10-13-2-1-7-28-13/h3-6,8-9,13,24-25H,1-2,7,10H2
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1.26E+3n/a 2.29E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242517
PNG
(US9422235, 102)
Show SMILES CCCCNc1ccc(c(c1)C(F)(F)F)S(=O)(=O)NCC1CC1
Show InChI InChI=1S/C15H21F3N2O2S/c1-2-3-8-19-12-6-7-14(13(9-12)15(16,17)18)23(21,22)20-10-11-4-5-11/h6-7,9,11,19-20H,2-5,8,10H2,1H3
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1.29E+3n/a 2.25E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242489
PNG
(US9422235, 70)
Show SMILES CN1C(=O)c2ccc(Nc3ccc(c(c3)C(F)(F)F)S(=O)(=O)NCC3CC3)cc2C1=O
Show InChI InChI=1S/C20H18F3N3O4S/c1-26-18(27)14-6-4-12(8-15(14)19(26)28)25-13-5-7-17(16(9-13)20(21,22)23)31(29,30)24-10-11-2-3-11/h4-9,11,24-25H,2-3,10H2,1H3
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1.32E+3n/a 2.41E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242491
PNG
(US9422235, 72)
Show SMILES CN(C)c1ccc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCC2CC2)cc1
Show InChI InChI=1S/C19H22F3N3O2S/c1-25(2)16-8-5-14(6-9-16)24-15-7-10-18(17(11-15)19(20,21)22)28(26,27)23-12-13-3-4-13/h5-11,13,23-24H,3-4,12H2,1-2H3
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1.45E+3n/a 2.66E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242490
PNG
(US9422235, 71)
Show SMILES CCn1nccc1Nc1ccc(c(c1)C(F)(F)F)S(=O)(=O)NCC1CC1
Show InChI InChI=1S/C16H19F3N4O2S/c1-2-23-15(7-8-20-23)22-12-5-6-14(13(9-12)16(17,18)19)26(24,25)21-10-11-3-4-11/h5-9,11,21-22H,2-4,10H2,1H3
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Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM242431
PNG
(US9422235, 4)
Show SMILES COc1cc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCC2CC2)cc(OC)c1
Show InChI InChI=1S/C19H21F3N2O4S/c1-27-15-7-14(8-16(10-15)28-2)24-13-5-6-18(17(9-13)19(20,21)22)29(25,26)23-11-12-3-4-12/h5-10,12,23-24H,3-4,11H2,1-2H3
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1.56E+3n/a 3.06E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM242445
PNG
(US9422235, 21)
Show SMILES COc1cc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCC2CCCO2)cc(OC)c1
Show InChI InChI=1S/C20H23F3N2O5S/c1-28-16-8-14(9-17(11-16)29-2)25-13-5-6-19(18(10-13)20(21,22)23)31(26,27)24-12-15-4-3-7-30-15/h5-6,8-11,15,24-25H,3-4,7,12H2,1-2H3
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1.59E+3n/a 3.58E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242448
PNG
(US9422235, 24)
Show SMILES COc1cc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCCN2CCOCC2)cc(OC)c1
Show InChI InChI=1S/C21H26F3N3O5S/c1-30-17-11-16(12-18(14-17)31-2)26-15-3-4-20(19(13-15)21(22,23)24)33(28,29)25-5-6-27-7-9-32-10-8-27/h3-4,11-14,25-26H,5-10H2,1-2H3
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Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242458
PNG
(US9422235, 34)
Show SMILES COCCN(CCOC)S(=O)(=O)c1ccc(Nc2cc(OC)cc(OC)c2)cc1C(F)(F)F
Show InChI InChI=1S/C21H27F3N2O6S/c1-29-9-7-26(8-10-30-2)33(27,28)20-6-5-15(13-19(20)21(22,23)24)25-16-11-17(31-3)14-18(12-16)32-4/h5-6,11-14,25H,7-10H2,1-4H3
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Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM242465
PNG
(US9422235, 41)
Show SMILES FC(F)(F)c1cc(NC2CC3CCC2C3)ccc1S(=O)(=O)NCC1CCOCC1
Show InChI InChI=1S/C20H27F3N2O3S/c21-20(22,23)17-11-16(25-18-10-14-1-2-15(18)9-14)3-4-19(17)29(26,27)24-12-13-5-7-28-8-6-13/h3-4,11,13-15,18,24-25H,1-2,5-10,12H2
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Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242444
PNG
(US9422235, 20)
Show SMILES COCCCNS(=O)(=O)c1ccc(Nc2cc(OC)cc(OC)c2)cc1C(F)(F)F
Show InChI InChI=1S/C19H23F3N2O5S/c1-27-8-4-7-23-30(25,26)18-6-5-13(11-17(18)19(20,21)22)24-14-9-15(28-2)12-16(10-14)29-3/h5-6,9-12,23-24H,4,7-8H2,1-3H3
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Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM242450
PNG
(US9422235, 26)
Show SMILES FC(F)(F)c1cc(NC2CC3CCC2C3)ccc1S(=O)(=O)NCC1CCCO1
Show InChI InChI=1S/C19H25F3N2O3S/c20-19(21,22)16-10-14(24-17-9-12-3-4-13(17)8-12)5-6-18(16)28(25,26)23-11-15-2-1-7-27-15/h5-6,10,12-13,15,17,23-24H,1-4,7-9,11H2
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Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242474
PNG
(US9422235, 51)
Show SMILES FC(F)(F)c1cc(Nc2cccnc2Cl)ccc1S(=O)(=O)NCC1CCOCC1
Show InChI InChI=1S/C18H19ClF3N3O3S/c19-17-15(2-1-7-23-17)25-13-3-4-16(14(10-13)18(20,21)22)29(26,27)24-11-12-5-8-28-9-6-12/h1-4,7,10,12,24-25H,5-6,8-9,11H2
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Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242519
PNG
(US9422235, 104)
Show SMILES FC(F)(F)c1cc(NCc2ccncc2)ccc1S(=O)(=O)NCC1CC1
Show InChI InChI=1S/C17H18F3N3O2S/c18-17(19,20)15-9-14(22-10-13-5-7-21-8-6-13)3-4-16(15)26(24,25)23-11-12-1-2-12/h3-9,12,22-23H,1-2,10-11H2
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1.88E+3n/a 3.17E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM242461
PNG
(US9422235, 37 | US9422235, 38)
Show SMILES Fc1ccc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCc2ccco2)c(F)c1
Show InChI InChI=1S/C18H13F5N2O3S/c19-11-3-5-16(15(20)8-11)25-12-4-6-17(14(9-12)18(21,22)23)29(26,27)24-10-13-2-1-7-28-13/h1-9,24-25H,10H2
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2.34E+3n/a 5.54E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242454
PNG
(US9422235, 30)
Show SMILES COc1cc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)Nc2cccc3cnccc23)cc(OC)c1
Show InChI InChI=1S/C24H20F3N3O4S/c1-33-18-10-17(11-19(13-18)34-2)29-16-6-7-23(21(12-16)24(25,26)27)35(31,32)30-22-5-3-4-15-14-28-9-8-20(15)22/h3-14,29-30H,1-2H3
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2.65E+3n/a 6.00E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM242440
PNG
(US9422235, 16)
Show SMILES COc1cc(OC)nc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCC2CC2)n1
Show InChI InChI=1S/C17H19F3N4O4S/c1-27-14-8-15(28-2)24-16(23-14)22-11-5-6-13(12(7-11)17(18,19)20)29(25,26)21-9-10-3-4-10/h5-8,10,21H,3-4,9H2,1-2H3,(H,22,23,24)
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2.67E+3n/a 6.00E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM242438
PNG
(US9422235, 12)
Show SMILES COc1cc(Nc2ccc(cc2)S(=O)(=O)NCC2CC2)cc(OC)c1
Show InChI InChI=1S/C18H22N2O4S/c1-23-16-9-15(10-17(11-16)24-2)20-14-5-7-18(8-6-14)25(21,22)19-12-13-3-4-13/h5-11,13,19-20H,3-4,12H2,1-2H3
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Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM242456
PNG
(US9422235, 32)
Show SMILES CCCN(CC1CC1)c1ccc(c(c1)C(F)(F)F)S(=O)(=O)NCC1CCCO1
Show InChI InChI=1S/C19H27F3N2O3S/c1-2-9-24(13-14-5-6-14)15-7-8-18(17(11-15)19(20,21)22)28(25,26)23-12-16-4-3-10-27-16/h7-8,11,14,16,23H,2-6,9-10,12-13H2,1H3
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Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM242455
PNG
(US9422235, 31)
Show SMILES FC(F)(F)c1cc(ccc1S(=O)(=O)NCC1CCCO1)N1CCc2ccccc12
Show InChI InChI=1S/C20H21F3N2O3S/c21-20(22,23)17-12-15(25-10-9-14-4-1-2-6-18(14)25)7-8-19(17)29(26,27)24-13-16-5-3-11-28-16/h1-2,4,6-8,12,16,24H,3,5,9-11,13H2
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Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242438
PNG
(US9422235, 12)
Show SMILES COc1cc(Nc2ccc(cc2)S(=O)(=O)NCC2CC2)cc(OC)c1
Show InChI InChI=1S/C18H22N2O4S/c1-23-16-9-15(10-17(11-16)24-2)20-14-5-7-18(8-6-14)25(21,22)19-12-13-3-4-13/h5-11,13,19-20H,3-4,12H2,1-2H3
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US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM242480
PNG
(US9422235, 58)
Show SMILES FC(F)(F)c1cc(NC2CC3CCC2C3)ccc1S(=O)(=O)NCC1CC1
Show InChI InChI=1S/C18H23F3N2O2S/c19-18(20,21)15-9-14(23-16-8-12-3-4-13(16)7-12)5-6-17(15)26(24,25)22-10-11-1-2-11/h5-6,9,11-13,16,22-23H,1-4,7-8,10H2
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Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242479
PNG
(US9422235, 57)
Show SMILES CN(CC1CC1)S(=O)(=O)c1ccc(Nc2ccc(Cl)cc2Cl)cc1C(F)(F)F
Show InChI InChI=1S/C18H17Cl2F3N2O2S/c1-25(10-11-2-3-11)28(26,27)17-7-5-13(9-14(17)18(21,22)23)24-16-6-4-12(19)8-15(16)20/h4-9,11,24H,2-3,10H2,1H3
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US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242483
PNG
(US9422235, 64)
Show SMILES CC(C)(C)CC(C)(C)NS(=O)(=O)c1ccc(Nc2ccc(Cl)cc2Cl)cc1C(F)(F)F
Show InChI InChI=1S/C21H25Cl2F3N2O2S/c1-19(2,3)12-20(4,5)28-31(29,30)18-9-7-14(11-15(18)21(24,25)26)27-17-8-6-13(22)10-16(17)23/h6-11,27-28H,12H2,1-5H3
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2.77E+3n/a 4.93E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM242504
PNG
(US9422235, 87)
Show SMILES FC(F)(F)c1cc(NC2CCCCCC2)ccc1S(=O)(=O)NCC1CC1
Show InChI InChI=1S/C18H25F3N2O2S/c19-18(20,21)16-11-15(23-14-5-3-1-2-4-6-14)9-10-17(16)26(24,25)22-12-13-7-8-13/h9-11,13-14,22-23H,1-8,12H2
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3.00E+3n/a 6.00E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM242430
PNG
(US9422235, 3)
Show SMILES FC(F)(F)c1cc(Nc2ccc(Cl)cc2Cl)ccc1S(=O)(=O)NCC1CC1
Show InChI InChI=1S/C17H15Cl2F3N2O2S/c18-11-3-5-15(14(19)7-11)24-12-4-6-16(13(8-12)17(20,21)22)27(25,26)23-9-10-1-2-10/h3-8,10,23-24H,1-2,9H2
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3.00E+3n/a 6.00E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM242460
PNG
(US9422235, 36)
Show SMILES Fc1ccc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCC2CC2)c(F)c1
Show InChI InChI=1S/C17H15F5N2O2S/c18-11-3-5-15(14(19)7-11)24-12-4-6-16(13(8-12)17(20,21)22)27(25,26)23-9-10-1-2-10/h3-8,10,23-24H,1-2,9H2
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3.00E+3n/a 6.00E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM242511
PNG
(US9422235, 94)
Show SMILES FC(F)(F)c1cc(NN2CCCCC2)ccc1S(=O)(=O)NCC1CC1
Show InChI InChI=1S/C16H22F3N3O2S/c17-16(18,19)14-10-13(21-22-8-2-1-3-9-22)6-7-15(14)25(23,24)20-11-12-4-5-12/h6-7,10,12,20-21H,1-5,8-9,11H2
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3.00E+3n/a 6.00E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM242461
PNG
(US9422235, 37 | US9422235, 38)
Show SMILES Fc1ccc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCc2ccco2)c(F)c1
Show InChI InChI=1S/C18H13F5N2O3S/c19-11-3-5-16(15(20)8-11)25-12-4-6-17(14(9-12)18(21,22)23)29(26,27)24-10-13-2-1-7-28-13/h1-9,24-25H,10H2
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3.00E+3n/a 6.00E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM242433
PNG
(US9422235, 6)
Show SMILES COc1ccc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCC2CC2)cc1
Show InChI InChI=1S/C18H19F3N2O3S/c1-26-15-7-4-13(5-8-15)23-14-6-9-17(16(10-14)18(19,20)21)27(24,25)22-11-12-2-3-12/h4-10,12,22-23H,2-3,11H2,1H3
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3.00E+3n/a 6.00E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM242509
PNG
(US9422235, 92 | US9422235, 96)
Show SMILES FC(F)(F)c1cc(NC2CCCCC2)ccc1S(=O)(=O)NCC1CC1
Show InChI InChI=1S/C17H23F3N2O2S/c18-17(19,20)15-10-14(22-13-4-2-1-3-5-13)8-9-16(15)25(23,24)21-11-12-6-7-12/h8-10,12-13,21-22H,1-7,11H2
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3.00E+3n/a 6.00E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM242438
PNG
(US9422235, 12)
Show SMILES COc1cc(Nc2ccc(cc2)S(=O)(=O)NCC2CC2)cc(OC)c1
Show InChI InChI=1S/C18H22N2O4S/c1-23-16-9-15(10-17(11-16)24-2)20-14-5-7-18(8-6-14)25(21,22)19-12-13-3-4-13/h5-11,13,19-20H,3-4,12H2,1-2H3
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3.00E+3n/an/an/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM242460
PNG
(US9422235, 36)
Show SMILES Fc1ccc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCC2CC2)c(F)c1
Show InChI InChI=1S/C17H15F5N2O2S/c18-11-3-5-15(14(19)7-11)24-12-4-6-16(13(8-12)17(20,21)22)27(25,26)23-9-10-1-2-10/h3-8,10,23-24H,1-2,9H2
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3.27E+3n/a 5.95E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242487
PNG
(US9422235, 68)
Show SMILES COC(=O)C1(CC1)NS(=O)(=O)c1ccc(Nc2ccc(Cl)cc2Cl)cc1C(F)(F)F
Show InChI InChI=1S/C18H15Cl2F3N2O4S/c1-29-16(26)17(6-7-17)25-30(27,28)15-5-3-11(9-12(15)18(21,22)23)24-14-4-2-10(19)8-13(14)20/h2-5,8-9,24-25H,6-7H2,1H3
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3.49E+3n/a 6.40E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242484
PNG
(US9422235, 65)
Show SMILES FC(F)(F)c1cc(Nc2ccc(Cl)cc2Cl)ccc1S(=O)(=O)Nc1ccccc1
Show InChI InChI=1S/C19H13Cl2F3N2O2S/c20-12-6-8-17(16(21)10-12)25-14-7-9-18(15(11-14)19(22,23)24)29(27,28)26-13-4-2-1-3-5-13/h1-11,25-26H
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3.51E+3n/a 6.25E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242473
PNG
(US9422235, 50)
Show SMILES CN(C)CC(C)(C)CNS(=O)(=O)c1ccc(Nc2ccc(Cl)cc2Cl)cc1C(F)(F)F
Show InChI InChI=1S/C20H24Cl2F3N3O2S/c1-19(2,12-28(3)4)11-26-31(29,30)18-8-6-14(10-15(18)20(23,24)25)27-17-7-5-13(21)9-16(17)22/h5-10,26-27H,11-12H2,1-4H3
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3.94E+3n/a 6.00E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242501
PNG
(US9422235, 83)
Show SMILES CC(C)(C)OC(=O)CN(CC1CC1)S(=O)(=O)c1ccc(NC2CC3CCC2C3)cc1C(F)(F)F
Show InChI InChI=1S/C24H33F3N2O4S/c1-23(2,3)33-22(30)14-29(13-15-4-5-15)34(31,32)21-9-8-18(12-19(21)24(25,26)27)28-20-11-16-6-7-17(20)10-16/h8-9,12,15-17,20,28H,4-7,10-11,13-14H2,1-3H3
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4.11E+3n/a 7.66E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM242436
PNG
(US9422235, 10)
Show SMILES CCCCNS(=O)(=O)c1ccc(Nc2ccc(Cl)cc2Cl)cc1C(F)(F)F
Show InChI InChI=1S/C17H17Cl2F3N2O2S/c1-2-3-8-23-27(25,26)16-7-5-12(10-13(16)17(20,21)22)24-15-6-4-11(18)9-14(15)19/h4-7,9-10,23-24H,2-3,8H2,1H3
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4.76E+3n/a 8.57E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM242493
PNG
(US9422235, 74)
Show SMILES CC(C)(NS(=O)(=O)c1ccc(NC2CC3CCC2C3)cc1C(F)(F)F)C1CC1
Show InChI InChI=1S/C20H27F3N2O2S/c1-19(2,14-5-6-14)25-28(26,27)18-8-7-15(11-16(18)20(21,22)23)24-17-10-12-3-4-13(17)9-12/h7-8,11-14,17,24-25H,3-6,9-10H2,1-2H3
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4.91E+3n/a 8.81E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM242453
PNG
(US9422235, 29)
Show SMILES COc1cc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCc2ccco2)cc(OC)c1
Show InChI InChI=1S/C20H19F3N2O5S/c1-28-16-8-14(9-17(11-16)29-2)25-13-5-6-19(18(10-13)20(21,22)23)31(26,27)24-12-15-4-3-7-30-15/h3-11,24-25H,12H2,1-2H3
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5.05E+3n/a 1.14E+4n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM242437
PNG
(US9422235, 11)
Show SMILES COc1cc(Nc2ccc(c(OC(F)(F)F)c2)S(=O)(=O)NCC2CC2)cc(OC)c1
Show InChI InChI=1S/C19H21F3N2O5S/c1-27-15-7-14(8-16(10-15)28-2)24-13-5-6-18(17(9-13)29-19(20,21)22)30(25,26)23-11-12-3-4-12/h5-10,12,23-24H,3-4,11H2,1-2H3
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5.56E+3n/a 1.10E+4n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM242438
PNG
(US9422235, 12)
Show SMILES COc1cc(Nc2ccc(cc2)S(=O)(=O)NCC2CC2)cc(OC)c1
Show InChI InChI=1S/C18H22N2O4S/c1-23-16-9-15(10-17(11-16)24-2)20-14-5-7-18(8-6-14)25(21,22)19-12-13-3-4-13/h5-11,13,19-20H,3-4,12H2,1-2H3
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Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM242459
PNG
(US9422235, 35)
Show SMILES FC(F)(F)c1cc(Nc2ccc(Cl)cc2Cl)ccc1S(=O)(=O)NCC1CCOCC1
Show InChI InChI=1S/C19H19Cl2F3N2O3S/c20-13-1-3-17(16(21)9-13)26-14-2-4-18(15(10-14)19(22,23)24)30(27,28)25-11-12-5-7-29-8-6-12/h1-4,9-10,12,25-26H,5-8,11H2
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5.84E+3n/a 1.38E+4n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242486
PNG
(US9422235, 67)
Show SMILES FC(F)(F)c1cc(Nc2ccc(Cl)cc2Cl)ccc1S(=O)(=O)NCc1ccccc1
Show InChI InChI=1S/C20H15Cl2F3N2O2S/c21-14-6-8-18(17(22)10-14)27-15-7-9-19(16(11-15)20(23,24)25)30(28,29)26-12-13-4-2-1-3-5-13/h1-11,26-27H,12H2
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6.00E+3n/a 6.00E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM242523
PNG
(US9422235, 108)
Show SMILES CC(C)(NS(=O)(=O)c1ccc(NC2CCCCC2)cc1C(F)(F)F)C1CC1
Show InChI InChI=1S/C19H27F3N2O2S/c1-18(2,13-8-9-13)24-27(25,26)17-11-10-15(12-16(17)19(20,21)22)23-14-6-4-3-5-7-14/h10-14,23-24H,3-9H2,1-2H3
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Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM242457
PNG
(US9422235, 33)
Show SMILES COc1cc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)N2CCc3ccccc23)cc(OC)c1
Show InChI InChI=1S/C23H21F3N2O4S/c1-31-18-11-17(12-19(14-18)32-2)27-16-7-8-22(20(13-16)23(24,25)26)33(29,30)28-10-9-15-5-3-4-6-21(15)28/h3-8,11-14,27H,9-10H2,1-2H3
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Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM242458
PNG
(US9422235, 34)
Show SMILES COCCN(CCOC)S(=O)(=O)c1ccc(Nc2cc(OC)cc(OC)c2)cc1C(F)(F)F
Show InChI InChI=1S/C21H27F3N2O6S/c1-29-9-7-26(8-10-30-2)33(27,28)20-6-5-15(13-19(20)21(22,23)24)25-16-11-17(31-3)14-18(12-16)32-4/h5-6,11-14,25H,7-10H2,1-4H3
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6.00E+3n/a 1.20E+4n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242477
PNG
(US9422235, 55)
Show SMILES CN(C)c1ccc(Nc2ccc(c(c2)C(F)(F)F)S(=O)(=O)NCC2CCOCC2)cc1
Show InChI InChI=1S/C21H26F3N3O3S/c1-27(2)18-6-3-16(4-7-18)26-17-5-8-20(19(13-17)21(22,23)24)31(28,29)25-14-15-9-11-30-12-10-15/h3-8,13,15,25-26H,9-12,14H2,1-2H3
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8.32E+3n/a 1.52E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM242437
PNG
(US9422235, 11)
Show SMILES COc1cc(Nc2ccc(c(OC(F)(F)F)c2)S(=O)(=O)NCC2CC2)cc(OC)c1
Show InChI InChI=1S/C19H21F3N2O5S/c1-27-15-7-14(8-16(10-15)28-2)24-13-5-6-18(17(9-13)29-19(20,21)22)30(25,26)23-11-12-3-4-12/h5-10,12,23-24H,3-4,11H2,1-2H3
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8.84E+3n/a 1.74E+4n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242508
PNG
(US9422235, 91)
Show SMILES CCCCCCNc1ccc(c(c1)C(F)(F)F)S(=O)(=O)NCC1CC1
Show InChI InChI=1S/C17H25F3N2O2S/c1-2-3-4-5-10-21-14-8-9-16(15(11-14)17(18,19)20)25(23,24)22-12-13-6-7-13/h8-9,11,13,21-22H,2-7,10,12H2,1H3
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1.66E+4n/a 2.94E+4n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM242429
PNG
(US9422235, 1)
Show SMILES FC(F)(F)c1cc(Nc2ccc(Cl)cc2Cl)ccc1S(=O)(=O)NCCN1CCOCC1
Show InChI InChI=1S/C19H20Cl2F3N3O3S/c20-13-1-3-17(16(21)11-13)26-14-2-4-18(15(12-14)19(22,23)24)31(28,29)25-5-6-27-7-9-30-10-8-27/h1-4,11-12,25-26H,5-10H2
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2.10E+4n/a 3.41E+4n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242437
PNG
(US9422235, 11)
Show SMILES COc1cc(Nc2ccc(c(OC(F)(F)F)c2)S(=O)(=O)NCC2CC2)cc(OC)c1
Show InChI InChI=1S/C19H21F3N2O5S/c1-27-15-7-14(8-16(10-15)28-2)24-13-5-6-18(17(9-13)29-19(20,21)22)30(25,26)23-11-12-3-4-12/h5-10,12,23-24H,3-4,11H2,1-2H3
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3.25E+4n/a 6.00E+4n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242513
PNG
(US9422235, 97)
Show SMILES FC(F)(F)c1cc(NC2CC2)ccc1S(=O)(=O)NCC1CC1
Show InChI InChI=1S/C14H17F3N2O2S/c15-14(16,17)12-7-11(19-10-3-4-10)5-6-13(12)22(20,21)18-8-9-1-2-9/h5-7,9-10,18-19H,1-4,8H2
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8.70E+4n/a 1.51E+5n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM242463
PNG
(US9422235, 39)
Show SMILES Fc1ccc(Nc2ccc(cc2)S(=O)(=O)NCC2CC2)c(F)c1
Show InChI InChI=1S/C16H16F2N2O2S/c17-12-3-8-16(15(18)9-12)20-13-4-6-14(7-5-13)23(21,22)19-10-11-1-2-11/h3-9,11,19-20H,1-2,10H2
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n/an/a 6.00E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM242463
PNG
(US9422235, 39)
Show SMILES Fc1ccc(Nc2ccc(cc2)S(=O)(=O)NCC2CC2)c(F)c1
Show InChI InChI=1S/C16H16F2N2O2S/c17-12-3-8-16(15(18)9-12)20-13-4-6-14(7-5-13)23(21,22)19-10-11-1-2-11/h3-9,11,19-20H,1-2,10H2
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n/an/a 6.00E+3n/an/an/an/an/an/a



Pharmos Corporation

US Patent


Assay Description
The binding assays were performed by testing the ability of the new compounds to displace the radiolabeled synthetic non-selective cannabinoid agonis...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%