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Patent code US9422240

Compile Data Set for Download or QSAR
Found 52 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Egl nine homolog 1


(Homo sapiens (Human))
BDBM242568
PNG
(US9422240, 1-378)
Show SMILES CC(C)c1ccc(Oc2ccc(CN3CCC(O)=C(C(=O)NCC(O)=O)C3=O)cn2)cc1
Show InChI InChI=1S/C23H25N3O6/c1-14(2)16-4-6-17(7-5-16)32-19-8-3-15(11-24-19)13-26-10-9-18(27)21(23(26)31)22(30)25-12-20(28)29/h3-8,11,14,27H,9-10,12-13H2,1-2H3,(H,25,30)(H,28,29)
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n/an/a 14n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM242567
PNG
(US9422240, 1-377)
Show SMILES CCCc1ccc(Oc2ccc(CN3CCC(O)=C(C(=O)NCC(O)=O)C3=O)cn2)cc1
Show InChI InChI=1S/C23H25N3O6/c1-2-3-15-4-7-17(8-5-15)32-19-9-6-16(12-24-19)14-26-11-10-18(27)21(23(26)31)22(30)25-13-20(28)29/h4-9,12,27H,2-3,10-11,13-14H2,1H3,(H,25,30)(H,28,29)
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n/an/a 15n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM242554
PNG
(US9422240, 1-296)
Show SMILES OC(=O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3ccc(cc3)C3CC3)nc2)C1=O
Show InChI InChI=1S/C23H23N3O6/c27-18-9-10-26(23(31)21(18)22(30)25-12-20(28)29)13-14-1-8-19(24-11-14)32-17-6-4-16(5-7-17)15-2-3-15/h1,4-8,11,15,27H,2-3,9-10,12-13H2,(H,25,30)(H,28,29)
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n/an/a 15n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM242526
PNG
(US9422240, 1-4)
Show SMILES OC1=C(C(=O)NCC([O-])=O)C(=O)N(Cc2ccc(Oc3ccc(Cl)cc3)nc2)CC1
Show InChI InChI=1S/C20H18ClN3O6/c21-13-2-4-14(5-3-13)30-16-6-1-12(9-22-16)11-24-8-7-15(25)18(20(24)29)19(28)23-10-17(26)27/h1-6,9,25H,7-8,10-11H2,(H,23,28)(H,26,27)/p-1
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n/an/a 19n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM242563
PNG
(US9422240, 1-366)
Show SMILES Cc1ccc(Oc2ccc(CN3CCC(O)=C(C(=O)NCC(O)=O)C3=O)cn2)cc1Cl
Show InChI InChI=1S/C21H20ClN3O6/c1-12-2-4-14(8-15(12)22)31-17-5-3-13(9-23-17)11-25-7-6-16(26)19(21(25)30)20(29)24-10-18(27)28/h2-5,8-9,26H,6-7,10-11H2,1H3,(H,24,29)(H,27,28)
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n/an/a 19n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM242577
PNG
(US9422240, 1-443)
Show SMILES OC(=O)CNC(=O)C1=C(O)CCN(Cc2cnc(Oc3ccc(cc3)C3CC3)cn2)C1=O
Show InChI InChI=1S/C22H22N4O6/c27-17-7-8-26(22(31)20(17)21(30)25-11-19(28)29)12-15-9-24-18(10-23-15)32-16-5-3-14(4-6-16)13-1-2-13/h3-6,9-10,13,27H,1-2,7-8,11-12H2,(H,25,30)(H,28,29)
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n/an/a 21n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM242566
PNG
(US9422240, 1-376)
Show SMILES CCc1ccc(Oc2ccc(CN3CCC(O)=C(C(=O)NCC(O)=O)C3=O)cn2)cc1
Show InChI InChI=1S/C22H23N3O6/c1-2-14-3-6-16(7-4-14)31-18-8-5-15(11-23-18)13-25-10-9-17(26)20(22(25)30)21(29)24-12-19(27)28/h3-8,11,26H,2,9-10,12-13H2,1H3,(H,24,29)(H,27,28)
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n/an/a 22n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM242535
PNG
(US9422240, 1-254)
Show SMILES OC(=O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3ccc(cc3)C(F)(F)F)nc2)C1=O
Show InChI InChI=1S/C21H18F3N3O6/c22-21(23,24)13-2-4-14(5-3-13)33-16-6-1-12(9-25-16)11-27-8-7-15(28)18(20(27)32)19(31)26-10-17(29)30/h1-6,9,28H,7-8,10-11H2,(H,26,31)(H,29,30)
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n/an/a 24n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM242542
PNG
(US9422240, 1-265 | US9422240, 1-355)
Show SMILES OC(=O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3ccc(Cl)cc3)cc2)C1=O
Show InChI InChI=1S/C21H19ClN2O6/c22-14-3-7-16(8-4-14)30-15-5-1-13(2-6-15)12-24-10-9-17(25)19(21(24)29)20(28)23-11-18(26)27/h1-8,25H,9-12H2,(H,23,28)(H,26,27)
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n/an/a 24n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM242575
PNG
(US9422240, 1-409)
Show SMILES Cc1cc(CN2CCC(O)=C(C(=O)NCC(O)=O)C2=O)cnc1Oc1ccc(Cl)cc1
Show InChI InChI=1S/C21H20ClN3O6/c1-12-8-13(9-24-20(12)31-15-4-2-14(22)3-5-15)11-25-7-6-16(26)18(21(25)30)19(29)23-10-17(27)28/h2-5,8-9,26H,6-7,10-11H2,1H3,(H,23,29)(H,27,28)
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n/an/a 25n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM242564
PNG
(US9422240, 1-367)
Show SMILES Cc1ccc(Oc2ccc(CN3CCC(O)=C(C(=O)NCC(O)=O)C3=O)cn2)cc1F
Show InChI InChI=1S/C21H20FN3O6/c1-12-2-4-14(8-15(12)22)31-17-5-3-13(9-23-17)11-25-7-6-16(26)19(21(25)30)20(29)24-10-18(27)28/h2-5,8-9,26H,6-7,10-11H2,1H3,(H,24,29)(H,27,28)
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM242571
PNG
(US9422240, 1-392)
Show SMILES Cc1ccc(Oc2ncc(CN3CCC(O)=C(C(=O)NCC(O)=O)C3=O)cc2Cl)cc1
Show InChI InChI=1S/C21H20ClN3O6/c1-12-2-4-14(5-3-12)31-20-15(22)8-13(9-24-20)11-25-7-6-16(26)18(21(25)30)19(29)23-10-17(27)28/h2-5,8-9,26H,6-7,10-11H2,1H3,(H,23,29)(H,27,28)
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM242572
PNG
(US9422240, 1-393)
Show SMILES Cc1ccc(Oc2ncc(CN3CCC(O)=C(C(=O)NCC(O)=O)C3=O)cc2F)cc1
Show InChI InChI=1S/C21H20FN3O6/c1-12-2-4-14(5-3-12)31-20-15(22)8-13(9-24-20)11-25-7-6-16(26)18(21(25)30)19(29)23-10-17(27)28/h2-5,8-9,26H,6-7,10-11H2,1H3,(H,23,29)(H,27,28)
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n/an/a 32n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM242576
PNG
(US9422240, 1-440)
Show SMILES OC(=O)CNC(=O)C1=C(O)CCN(Cc2cnc(Oc3ccc(Cl)cc3)cn2)C1=O
Show InChI InChI=1S/C19H17ClN4O6/c20-11-1-3-13(4-2-11)30-15-8-21-12(7-22-15)10-24-6-5-14(25)17(19(24)29)18(28)23-9-16(26)27/h1-4,7-8,25H,5-6,9-10H2,(H,23,28)(H,26,27)
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n/an/a 39n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM242528
PNG
(US9422240, 1-70)
Show SMILES Cc1ccc(Oc2ccc(CN3CCC(O)=C(C(=O)NCC(O)=O)C3=O)cn2)cc1
Show InChI InChI=1S/C21H21N3O6/c1-13-2-5-15(6-3-13)30-17-7-4-14(10-22-17)12-24-9-8-16(25)19(21(24)29)20(28)23-11-18(26)27/h2-7,10,25H,8-9,11-12H2,1H3,(H,23,28)(H,26,27)
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM242532
PNG
(US9422240, 1-225)
Show SMILES OC(=O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3ccc(cc3)C#N)nc2)C1=O
Show InChI InChI=1S/C21H18N4O6/c22-9-13-1-4-15(5-2-13)31-17-6-3-14(10-23-17)12-25-8-7-16(26)19(21(25)30)20(29)24-11-18(27)28/h1-6,10,26H,7-8,11-12H2,(H,24,29)(H,27,28)
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM242548
PNG
(US9422240, 1-284)
Show SMILES OC(=O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3cccc(Cl)c3)nc2)C1=O
Show InChI InChI=1S/C20H18ClN3O6/c21-13-2-1-3-14(8-13)30-16-5-4-12(9-22-16)11-24-7-6-15(25)18(20(24)29)19(28)23-10-17(26)27/h1-5,8-9,25H,6-7,10-11H2,(H,23,28)(H,26,27)
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM242565
PNG
(US9422240, 1-368)
Show SMILES Cc1cc(Oc2ccc(CN3CCC(O)=C(C(=O)NCC(O)=O)C3=O)cn2)ccc1F
Show InChI InChI=1S/C21H20FN3O6/c1-12-8-14(3-4-15(12)22)31-17-5-2-13(9-23-17)11-25-7-6-16(26)19(21(25)30)20(29)24-10-18(27)28/h2-5,8-9,26H,6-7,10-11H2,1H3,(H,24,29)(H,27,28)
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM242558
PNG
(US9422240, 1-353)
Show SMILES OC(=O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3ccc(Cl)cc3)nc2)C1=O
Show InChI InChI=1S/C20H18ClN3O6/c21-13-2-4-14(5-3-13)30-16-6-1-12(9-22-16)11-24-8-7-15(25)18(20(24)29)19(28)23-10-17(26)27/h1-6,9,25H,7-8,10-11H2,(H,23,28)(H,26,27)
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n/an/a 43n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM242549
PNG
(US9422240, 1-285)
Show SMILES OC(=O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3cccc(c3)C(F)(F)F)nc2)C1=O
Show InChI InChI=1S/C21H18F3N3O6/c22-21(23,24)13-2-1-3-14(8-13)33-16-5-4-12(9-25-16)11-27-7-6-15(28)18(20(27)32)19(31)26-10-17(29)30/h1-5,8-9,28H,6-7,10-11H2,(H,26,31)(H,29,30)
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n/an/a 43n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM242551
PNG
(US9422240, 1-287)
Show SMILES OC(=O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3cccc(OC(F)(F)F)c3)nc2)C1=O
Show InChI InChI=1S/C21H18F3N3O7/c22-21(23,24)34-14-3-1-2-13(8-14)33-16-5-4-12(9-25-16)11-27-7-6-15(28)18(20(27)32)19(31)26-10-17(29)30/h1-5,8-9,28H,6-7,10-11H2,(H,26,31)(H,29,30)
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n/an/a 45n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM242570
PNG
(US9422240, 1-386)
Show SMILES Cc1ccc(Oc2ccc(CN3CCC(O)=C(C(=O)NCC(O)=O)C3=O)cc2)cc1C
Show InChI InChI=1S/C23H24N2O6/c1-14-3-6-18(11-15(14)2)31-17-7-4-16(5-8-17)13-25-10-9-19(26)21(23(25)30)22(29)24-12-20(27)28/h3-8,11,26H,9-10,12-13H2,1-2H3,(H,24,29)(H,27,28)
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n/an/a 48n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM242531
PNG
(US9422240, 1-209)
Show SMILES Cc1ccc(Oc2ccc(CN3CCC(O)=C(C(=O)NCC(O)=O)C3=O)cc2)cc1
Show InChI InChI=1S/C22H22N2O6/c1-14-2-6-16(7-3-14)30-17-8-4-15(5-9-17)13-24-11-10-18(25)20(22(24)29)21(28)23-12-19(26)27/h2-9,25H,10-13H2,1H3,(H,23,28)(H,26,27)
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM242542
PNG
(US9422240, 1-265 | US9422240, 1-355)
Show SMILES OC(=O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3ccc(Cl)cc3)cc2)C1=O
Show InChI InChI=1S/C21H19ClN2O6/c22-14-3-7-16(8-4-14)30-15-5-1-13(2-6-15)12-24-10-9-17(25)19(21(24)29)20(28)23-11-18(26)27/h1-8,25H,9-12H2,(H,23,28)(H,26,27)
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM242569
PNG
(US9422240, 1-385)
Show SMILES Cc1ccc(Oc2cnc(CN3CCC(O)=C(C(=O)NCC(O)=O)C3=O)cn2)cc1
Show InChI InChI=1S/C20H20N4O6/c1-12-2-4-14(5-3-12)30-16-9-21-13(8-22-16)11-24-7-6-15(25)18(20(24)29)19(28)23-10-17(26)27/h2-5,8-9,25H,6-7,10-11H2,1H3,(H,23,28)(H,26,27)
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM242562
PNG
(US9422240, 1-365)
Show SMILES OC(=O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3ccc(nc3)C(F)(F)F)cc2)C1=O
Show InChI InChI=1S/C21H18F3N3O6/c22-21(23,24)16-6-5-14(9-25-16)33-13-3-1-12(2-4-13)11-27-8-7-15(28)18(20(27)32)19(31)26-10-17(29)30/h1-6,9,28H,7-8,10-11H2,(H,26,31)(H,29,30)
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM242573
PNG
(US9422240, 1-404)
Show SMILES OC(=O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3ccc(cn3)C3CC3)cc2)C1=O
Show InChI InChI=1S/C23H23N3O6/c27-18-9-10-26(23(31)21(18)22(30)25-12-20(28)29)13-14-1-6-17(7-2-14)32-19-8-5-16(11-24-19)15-3-4-15/h1-2,5-8,11,15,27H,3-4,9-10,12-13H2,(H,25,30)(H,28,29)
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM242530
PNG
(US9422240, 1-205)
Show SMILES Cc1ccc(Oc2ccc(CN3C(=O)C(C(=O)NCC(O)=O)=C(O)CC3(C)C)cn2)cc1
Show InChI InChI=1S/C23H25N3O6/c1-14-4-7-16(8-5-14)32-18-9-6-15(11-24-18)13-26-22(31)20(17(27)10-23(26,2)3)21(30)25-12-19(28)29/h4-9,11,27H,10,12-13H2,1-3H3,(H,25,30)(H,28,29)
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM242561
PNG
(US9422240, 1-356)
Show SMILES OC(=O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3ccc(cc3)C(F)(F)F)cn2)C1=O
Show InChI InChI=1S/C21H18F3N3O6/c22-21(23,24)12-1-4-14(5-2-12)33-15-6-3-13(25-9-15)11-27-8-7-16(28)18(20(27)32)19(31)26-10-17(29)30/h1-6,9,28H,7-8,10-11H2,(H,26,31)(H,29,30)
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM242559
PNG
(US9422240, 1-354)
Show SMILES COc1cccc(Oc2ccc(CN3CCC(O)=C(C(=O)NCC(O)=O)C3=O)cn2)c1
Show InChI InChI=1S/C21H21N3O7/c1-30-14-3-2-4-15(9-14)31-17-6-5-13(10-22-17)12-24-8-7-16(25)19(21(24)29)20(28)23-11-18(26)27/h2-6,9-10,25H,7-8,11-12H2,1H3,(H,23,28)(H,26,27)
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM242550
PNG
(US9422240, 1-286)
Show SMILES COc1cccc(Oc2ccc(CN3CCC(O)=C(C(=O)NCC(O)=O)C3=O)cc2)c1
Show InChI InChI=1S/C22H22N2O7/c1-30-16-3-2-4-17(11-16)31-15-7-5-14(6-8-15)13-24-10-9-18(25)20(22(24)29)21(28)23-12-19(26)27/h2-8,11,25H,9-10,12-13H2,1H3,(H,23,28)(H,26,27)
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM242539
PNG
(US9422240, 1-258)
Show SMILES OC(=O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3cccc(F)c3)cc2)C1=O
Show InChI InChI=1S/C21H19FN2O6/c22-14-2-1-3-16(10-14)30-15-6-4-13(5-7-15)12-24-9-8-17(25)19(21(24)29)20(28)23-11-18(26)27/h1-7,10,25H,8-9,11-12H2,(H,23,28)(H,26,27)
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM242547
PNG
(US9422240, 1-283)
Show SMILES Cc1ccccc1Oc1ccc(CN2CCC(O)=C(C(=O)NCC(O)=O)C2=O)cc1
Show InChI InChI=1S/C22H22N2O6/c1-14-4-2-3-5-18(14)30-16-8-6-15(7-9-16)13-24-11-10-17(25)20(22(24)29)21(28)23-12-19(26)27/h2-9,25H,10-13H2,1H3,(H,23,28)(H,26,27)
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM242537
PNG
(US9422240, 1-256)
Show SMILES OC(=O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3cccc(F)c3)nc2)C1=O
Show InChI InChI=1S/C20H18FN3O6/c21-13-2-1-3-14(8-13)30-16-5-4-12(9-22-16)11-24-7-6-15(25)18(20(24)29)19(28)23-10-17(26)27/h1-5,8-9,25H,6-7,10-11H2,(H,23,28)(H,26,27)
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM242536
PNG
(US9422240, 1-255)
Show SMILES Cc1cccc(Oc2ccc(CN3CCC(O)=C(C(=O)NCC(O)=O)C3=O)cn2)c1
Show InChI InChI=1S/C21H21N3O6/c1-13-3-2-4-15(9-13)30-17-6-5-14(10-22-17)12-24-8-7-16(25)19(21(24)29)20(28)23-11-18(26)27/h2-6,9-10,25H,7-8,11-12H2,1H3,(H,23,28)(H,26,27)
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM242553
PNG
(US9422240, 1-289)
Show SMILES OC(=O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3ccc(Cl)cn3)cc2)C1=O
Show InChI InChI=1S/C20H18ClN3O6/c21-13-3-6-16(22-9-13)30-14-4-1-12(2-5-14)11-24-8-7-15(25)18(20(24)29)19(28)23-10-17(26)27/h1-6,9,25H,7-8,10-11H2,(H,23,28)(H,26,27)
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM242541
PNG
(US9422240, 1-260)
Show SMILES Cc1ccc(Oc2ccc(CN3CCC(O)=C(C(=O)NCC(O)=O)C3=O)nc2)cc1
Show InChI InChI=1S/C21H21N3O6/c1-13-2-5-15(6-3-13)30-16-7-4-14(22-10-16)12-24-9-8-17(25)19(21(24)29)20(28)23-11-18(26)27/h2-7,10,25H,8-9,11-12H2,1H3,(H,23,28)(H,26,27)
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM242574
PNG
(US9422240, 1-408)
Show SMILES Cc1ccc(Oc2ncc(CN3CCC(O)=C(C(=O)NCC(O)=O)C3=O)cn2)cc1
Show InChI InChI=1S/C20H20N4O6/c1-12-2-4-14(5-3-12)30-20-22-8-13(9-23-20)11-24-7-6-15(25)17(19(24)29)18(28)21-10-16(26)27/h2-5,8-9,25H,6-7,10-11H2,1H3,(H,21,28)(H,26,27)
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM242538
PNG
(US9422240, 1-257)
Show SMILES Cc1cccc(Oc2ccc(CN3CCC(O)=C(C(=O)NCC(O)=O)C3=O)cc2)c1
Show InChI InChI=1S/C22H22N2O6/c1-14-3-2-4-17(11-14)30-16-7-5-15(6-8-16)13-24-10-9-18(25)20(22(24)29)21(28)23-12-19(26)27/h2-8,11,25H,9-10,12-13H2,1H3,(H,23,28)(H,26,27)
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM242546
PNG
(US9422240, 1-282)
Show SMILES OC(=O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3ccccc3F)cc2)C1=O
Show InChI InChI=1S/C21H19FN2O6/c22-15-3-1-2-4-17(15)30-14-7-5-13(6-8-14)12-24-10-9-16(25)19(21(24)29)20(28)23-11-18(26)27/h1-8,25H,9-12H2,(H,23,28)(H,26,27)
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TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM242556
PNG
(US9422240, 1-298)
Show SMILES OC(=O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3ccc(cn3)C(F)(F)F)cc2)C1=O
Show InChI InChI=1S/C21H18F3N3O6/c22-21(23,24)13-3-6-16(25-9-13)33-14-4-1-12(2-5-14)11-27-8-7-15(28)18(20(27)32)19(31)26-10-17(29)30/h1-6,9,28H,7-8,10-11H2,(H,26,31)(H,29,30)
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n/an/a 79n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM242534
PNG
(US9422240, 1-252)
Show SMILES OC(=O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3ccc(F)cc3)nc2)C1=O
Show InChI InChI=1S/C20H18FN3O6/c21-13-2-4-14(5-3-13)30-16-6-1-12(9-22-16)11-24-8-7-15(25)18(20(24)29)19(28)23-10-17(26)27/h1-6,9,25H,7-8,10-11H2,(H,23,28)(H,26,27)
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n/an/a 87n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM242527
PNG
(US9422240, 1-28)
Show SMILES OC(=O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3ccccc3)cc2)C1=O
Show InChI InChI=1S/C21H20N2O6/c24-17-10-11-23(21(28)19(17)20(27)22-12-18(25)26)13-14-6-8-16(9-7-14)29-15-4-2-1-3-5-15/h1-9,24H,10-13H2,(H,22,27)(H,25,26)
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n/an/a 88n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM242555
PNG
(US9422240, 1-297)
Show SMILES Cc1ccc(Oc2ccc(CN3CCC(O)=C(C(=O)NCC(O)=O)C3=O)cc2)nc1
Show InChI InChI=1S/C21H21N3O6/c1-13-2-7-17(22-10-13)30-15-5-3-14(4-6-15)12-24-9-8-16(25)19(21(24)29)20(28)23-11-18(26)27/h2-7,10,25H,8-9,11-12H2,1H3,(H,23,28)(H,26,27)
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US Patent
n/an/a 89n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM242557
PNG
(US9422240, 1-333)
Show SMILES Cc1ccc(Oc2ncc(CN3CCC(O)=C(C(=O)NCC(O)=O)C3=O)cc2C)cn1
Show InChI InChI=1S/C21H22N4O6/c1-12-7-14(8-24-20(12)31-15-4-3-13(2)22-9-15)11-25-6-5-16(26)18(21(25)30)19(29)23-10-17(27)28/h3-4,7-9,26H,5-6,10-11H2,1-2H3,(H,23,29)(H,27,28)
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n/an/a 92n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM242529
PNG
(US9422240, 1-72)
Show SMILES OC(=O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3ccccc3)nc2)C1=O
Show InChI InChI=1S/C20H19N3O6/c24-15-8-9-23(20(28)18(15)19(27)22-11-17(25)26)12-13-6-7-16(21-10-13)29-14-4-2-1-3-5-14/h1-7,10,24H,8-9,11-12H2,(H,22,27)(H,25,26)
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n/an/a 94n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM242540
PNG
(US9422240, 1-259)
Show SMILES OC(=O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3ccc(F)cc3)cn2)C1=O
Show InChI InChI=1S/C20H18FN3O6/c21-12-1-4-14(5-2-12)30-15-6-3-13(22-9-15)11-24-8-7-16(25)18(20(24)29)19(28)23-10-17(26)27/h1-6,9,25H,7-8,10-11H2,(H,23,28)(H,26,27)
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n/an/a 96n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM242545
PNG
(US9422240, 1-275)
Show SMILES Cc1ccccc1Oc1ccc(CN2CCC(O)=C(C(=O)NCC(O)=O)C2=O)cn1
Show InChI InChI=1S/C21H21N3O6/c1-13-4-2-3-5-16(13)30-17-7-6-14(10-22-17)12-24-9-8-15(25)19(21(24)29)20(28)23-11-18(26)27/h2-7,10,25H,8-9,11-12H2,1H3,(H,23,28)(H,26,27)
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n/an/a 99n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM242544
PNG
(US9422240, 1-274)
Show SMILES OC(=O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3ccccc3F)nc2)C1=O
Show InChI InChI=1S/C20H18FN3O6/c21-13-3-1-2-4-15(13)30-16-6-5-12(9-22-16)11-24-8-7-14(25)18(20(24)29)19(28)23-10-17(26)27/h1-6,9,25H,7-8,10-11H2,(H,23,28)(H,26,27)
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n/an/a 108n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM242543
PNG
(US9422240, 1-273)
Show SMILES Cc1ccc(Oc2ccc(CN3CCC(O)=C(C(=O)NCC(O)=O)C3=O)cc2)cn1
Show InChI InChI=1S/C21H21N3O6/c1-13-2-5-16(10-22-13)30-15-6-3-14(4-7-15)12-24-9-8-17(25)19(21(24)29)20(28)23-11-18(26)27/h2-7,10,25H,8-9,11-12H2,1H3,(H,23,28)(H,26,27)
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n/an/a 112n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM242552
PNG
(US9422240, 1-288)
Show SMILES OC(=O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3ccc(F)cn3)cc2)C1=O
Show InChI InChI=1S/C20H18FN3O6/c21-13-3-6-16(22-9-13)30-14-4-1-12(2-5-14)11-24-8-7-15(25)18(20(24)29)19(28)23-10-17(26)27/h1-6,9,25H,7-8,10-11H2,(H,23,28)(H,26,27)
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n/an/a 146n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...


Citation and Details
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM242533
PNG
(US9422240, 1-226)
Show SMILES OC(=O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3ncccn3)cc2)C1=O
Show InChI InChI=1S/C19H18N4O6/c24-14-6-9-23(18(28)16(14)17(27)22-10-15(25)26)11-12-2-4-13(5-3-12)29-19-20-7-1-8-21-19/h1-5,7-8,24H,6,9-11H2,(H,22,27)(H,25,26)
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n/an/a 409n/an/an/an/an/an/a



TAISHO PHARMACEUTICAL CO., LTD

US Patent


Assay Description
The enzyme and the substrate were each diluted with a 50 mM tris-hydrochloric acid buffer (pH 7.5) containing 12.5 mM KCl, 3.75 mM MgCl2, 25 μM ...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%