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Patent code US9422263

Compile Data Set for Download or QSAR
Found 19 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Proto-oncogene c-Met


(Homo sapiens (Human))
BDBM240734
PNG
(US9422263, 5 | US9422263, 6)
Show SMILES Cc1n[nH]c2ccc(cc12)C1C(C#N)=C(C)NC(=C1C#N)C(F)(F)F
Show InChI InChI=1S/C17H12F3N5/c1-8-12(6-21)15(13(7-22)16(23-8)17(18,19)20)10-3-4-14-11(5-10)9(2)24-25-14/h3-5,15,23H,1-2H3,(H,24,25)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The N-terminally His6-tagged recombinant kinase domain of the human c-Met (amino acids 960-1390), expressed in insect cells (SF21) and purified by Ni...


US Patent US9422263 (2016)


BindingDB Entry DOI: 10.7270/Q2JQ0ZW2
More data for this
Ligand-Target Pair
Proto-oncogene c-Met


(Homo sapiens (Human))
BDBM62337
PNG
(Synthetic Example 4 (WO2008/071451))
Show SMILES CC1=C(C#N)C(C(C#N)=C(C)N1)c1cccc2[nH]ncc12
Show InChI InChI=1S/C16H13N5/c1-9-12(6-17)16(13(7-18)10(2)20-9)11-4-3-5-15-14(11)8-19-21-15/h3-5,8,16,20H,1-2H3,(H,19,21)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The N-terminally His6-tagged recombinant kinase domain of the human c-Met (amino acids 960-1390), expressed in insect cells (SF21) and purified by Ni...


US Patent US9422263 (2016)


BindingDB Entry DOI: 10.7270/Q2JQ0ZW2
More data for this
Ligand-Target Pair
Proto-oncogene c-Met


(Homo sapiens (Human))
BDBM240732
PNG
(US9422263, 2 | US9422263, 3)
Show SMILES Cc1n[nH]c2ccc(cc12)C1C(C#N)=C(C)NC(C(F)F)=C1C#N
Show InChI InChI=1S/C17H13F2N5/c1-8-12(6-20)15(13(7-21)16(22-8)17(18)19)10-3-4-14-11(5-10)9(2)23-24-14/h3-5,15,17,22H,1-2H3,(H,23,24)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The N-terminally His6-tagged recombinant kinase domain of the human c-Met (amino acids 960-1390), expressed in insect cells (SF21) and purified by Ni...


US Patent US9422263 (2016)


BindingDB Entry DOI: 10.7270/Q2JQ0ZW2
More data for this
Ligand-Target Pair
Proto-oncogene c-Met


(Homo sapiens (Human))
BDBM240732
PNG
(US9422263, 2 | US9422263, 3)
Show SMILES Cc1n[nH]c2ccc(cc12)C1C(C#N)=C(C)NC(C(F)F)=C1C#N
Show InChI InChI=1S/C17H13F2N5/c1-8-12(6-20)15(13(7-21)16(22-8)17(18)19)10-3-4-14-11(5-10)9(2)23-24-14/h3-5,15,17,22H,1-2H3,(H,23,24)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The N-terminally His6-tagged recombinant kinase domain of the human c-Met (amino acids 960-1390), expressed in insect cells (SF21) and purified by Ni...


US Patent US9422263 (2016)


BindingDB Entry DOI: 10.7270/Q2JQ0ZW2
More data for this
Ligand-Target Pair
Proto-oncogene c-Met


(Homo sapiens (Human))
BDBM240737
PNG
(US9422263, 14)
Show SMILES Cc1n[nH]c2cc(F)c(cc12)C1C(C#N)=C(NC(C(F)F)=C1C#N)C(F)F
Show InChI InChI=1S/C17H10F5N5/c1-6-7-2-8(11(18)3-12(7)27-26-6)13-9(4-23)14(16(19)20)25-15(17(21)22)10(13)5-24/h2-3,13,16-17,25H,1H3,(H,26,27)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The N-terminally His6-tagged recombinant kinase domain of the human c-Met (amino acids 960-1390), expressed in insect cells (SF21) and purified by Ni...


US Patent US9422263 (2016)


BindingDB Entry DOI: 10.7270/Q2JQ0ZW2
More data for this
Ligand-Target Pair
Proto-oncogene c-Met


(Homo sapiens (Human))
BDBM240741
PNG
(US9422263, 30)
Show SMILES CCC(F)(F)C1=C(C#N)C(C(C#N)=C(C)N1)c1ccc2[nH]nc(C)c2c1
Show InChI InChI=1S/C19H17F2N5/c1-4-19(20,21)18-15(9-23)17(14(8-22)10(2)24-18)12-5-6-16-13(7-12)11(3)25-26-16/h5-7,17,24H,4H2,1-3H3,(H,25,26)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The N-terminally His6-tagged recombinant kinase domain of the human c-Met (amino acids 960-1390), expressed in insect cells (SF21) and purified by Ni...


US Patent US9422263 (2016)


BindingDB Entry DOI: 10.7270/Q2JQ0ZW2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM240732
PNG
(US9422263, 2 | US9422263, 3)
Show SMILES Cc1n[nH]c2ccc(cc12)C1C(C#N)=C(C)NC(C(F)F)=C1C#N
Show InChI InChI=1S/C17H13F2N5/c1-8-12(6-20)15(13(7-21)16(22-8)17(18)19)10-3-4-14-11(5-10)9(2)23-24-14/h3-5,15,17,22H,1-2H3,(H,23,24)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant human c-Met protein (Invitrogen, Carlsbad, Calif., USA) is used. As substrate for the kinase reaction the peptide KKKSPGEYVNIEFG (JPT, Ge...


US Patent US9422263 (2016)


BindingDB Entry DOI: 10.7270/Q2JQ0ZW2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM240732
PNG
(US9422263, 2 | US9422263, 3)
Show SMILES Cc1n[nH]c2ccc(cc12)C1C(C#N)=C(C)NC(C(F)F)=C1C#N
Show InChI InChI=1S/C17H13F2N5/c1-8-12(6-20)15(13(7-21)16(22-8)17(18)19)10-3-4-14-11(5-10)9(2)23-24-14/h3-5,15,17,22H,1-2H3,(H,23,24)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant human c-Met protein (Invitrogen, Carlsbad, Calif., USA) is used. As substrate for the kinase reaction the peptide KKKSPGEYVNIEFG (JPT, Ge...


US Patent US9422263 (2016)


BindingDB Entry DOI: 10.7270/Q2JQ0ZW2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM240742
PNG
(US9422263, 43 | US9422263, 44)
Show SMILES CN1C(C)=C(C#N)C(C(C#N)=C1C(F)(F)F)c1ccc2[nH]nc(C)c2c1
Show InChI InChI=1S/C18H14F3N5/c1-9-12-6-11(4-5-15(12)25-24-9)16-13(7-22)10(2)26(3)17(14(16)8-23)18(19,20)21/h4-6,16H,1-3H3,(H,24,25)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant human c-Met protein (Invitrogen, Carlsbad, Calif., USA) is used. As substrate for the kinase reaction the peptide KKKSPGEYVNIEFG (JPT, Ge...


US Patent US9422263 (2016)


BindingDB Entry DOI: 10.7270/Q2JQ0ZW2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM62337
PNG
(Synthetic Example 4 (WO2008/071451))
Show SMILES CC1=C(C#N)C(C(C#N)=C(C)N1)c1cccc2[nH]ncc12
Show InChI InChI=1S/C16H13N5/c1-9-12(6-17)16(13(7-18)10(2)20-9)11-4-3-5-15-14(11)8-19-21-15/h3-5,8,16,20H,1-2H3,(H,19,21)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant human c-Met protein (Invitrogen, Carlsbad, Calif., USA) is used. As substrate for the kinase reaction the peptide KKKSPGEYVNIEFG (JPT, Ge...


US Patent US9422263 (2016)


BindingDB Entry DOI: 10.7270/Q2JQ0ZW2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM240742
PNG
(US9422263, 43 | US9422263, 44)
Show SMILES CN1C(C)=C(C#N)C(C(C#N)=C1C(F)(F)F)c1ccc2[nH]nc(C)c2c1
Show InChI InChI=1S/C18H14F3N5/c1-9-12-6-11(4-5-15(12)25-24-9)16-13(7-22)10(2)26(3)17(14(16)8-23)18(19,20)21/h4-6,16H,1-3H3,(H,24,25)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant human c-Met protein (Invitrogen, Carlsbad, Calif., USA) is used. As substrate for the kinase reaction the peptide KKKSPGEYVNIEFG (JPT, Ge...


US Patent US9422263 (2016)


BindingDB Entry DOI: 10.7270/Q2JQ0ZW2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM240736
PNG
(US9422263, 8)
Show SMILES Cc1n[nH]c2cc(F)c(cc12)C1C(C#N)=C(C)NC(C(F)F)=C1C#N
Show InChI InChI=1S/C17H12F3N5/c1-7-11(5-21)15(12(6-22)16(23-7)17(19)20)10-3-9-8(2)24-25-14(9)4-13(10)18/h3-4,15,17,23H,1-2H3,(H,24,25)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant human c-Met protein (Invitrogen, Carlsbad, Calif., USA) is used. As substrate for the kinase reaction the peptide KKKSPGEYVNIEFG (JPT, Ge...


US Patent US9422263 (2016)


BindingDB Entry DOI: 10.7270/Q2JQ0ZW2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM240738
PNG
(US9422263, 17)
Show SMILES CC1=C(C#N)C(C(C#N)=C(N1)C(F)F)c1cc2cn[nH]c2cc1F
Show InChI InChI=1S/C16H10F3N5/c1-7-10(4-20)14(11(5-21)15(23-7)16(18)19)9-2-8-6-22-24-13(8)3-12(9)17/h2-3,6,14,16,23H,1H3,(H,22,24)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant human c-Met protein (Invitrogen, Carlsbad, Calif., USA) is used. As substrate for the kinase reaction the peptide KKKSPGEYVNIEFG (JPT, Ge...


US Patent US9422263 (2016)


BindingDB Entry DOI: 10.7270/Q2JQ0ZW2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM240734
PNG
(US9422263, 5 | US9422263, 6)
Show SMILES Cc1n[nH]c2ccc(cc12)C1C(C#N)=C(C)NC(=C1C#N)C(F)(F)F
Show InChI InChI=1S/C17H12F3N5/c1-8-12(6-21)15(13(7-22)16(23-8)17(18,19)20)10-3-4-14-11(5-10)9(2)24-25-14/h3-5,15,23H,1-2H3,(H,24,25)
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n/an/a 12n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant human c-Met protein (Invitrogen, Carlsbad, Calif., USA) is used. As substrate for the kinase reaction the peptide KKKSPGEYVNIEFG (JPT, Ge...


US Patent US9422263 (2016)


BindingDB Entry DOI: 10.7270/Q2JQ0ZW2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM240734
PNG
(US9422263, 5 | US9422263, 6)
Show SMILES Cc1n[nH]c2ccc(cc12)C1C(C#N)=C(C)NC(=C1C#N)C(F)(F)F
Show InChI InChI=1S/C17H12F3N5/c1-8-12(6-21)15(13(7-22)16(23-8)17(18,19)20)10-3-4-14-11(5-10)9(2)24-25-14/h3-5,15,23H,1-2H3,(H,24,25)
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n/an/a 12n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant human c-Met protein (Invitrogen, Carlsbad, Calif., USA) is used. As substrate for the kinase reaction the peptide KKKSPGEYVNIEFG (JPT, Ge...


US Patent US9422263 (2016)


BindingDB Entry DOI: 10.7270/Q2JQ0ZW2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM240741
PNG
(US9422263, 30)
Show SMILES CCC(F)(F)C1=C(C#N)C(C(C#N)=C(C)N1)c1ccc2[nH]nc(C)c2c1
Show InChI InChI=1S/C19H17F2N5/c1-4-19(20,21)18-15(9-23)17(14(8-22)10(2)24-18)12-5-6-16-13(7-12)11(3)25-26-16/h5-7,17,24H,4H2,1-3H3,(H,25,26)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant human c-Met protein (Invitrogen, Carlsbad, Calif., USA) is used. As substrate for the kinase reaction the peptide KKKSPGEYVNIEFG (JPT, Ge...


US Patent US9422263 (2016)


BindingDB Entry DOI: 10.7270/Q2JQ0ZW2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM240737
PNG
(US9422263, 14)
Show SMILES Cc1n[nH]c2cc(F)c(cc12)C1C(C#N)=C(NC(C(F)F)=C1C#N)C(F)F
Show InChI InChI=1S/C17H10F5N5/c1-6-7-2-8(11(18)3-12(7)27-26-6)13-9(4-23)14(16(19)20)25-15(17(21)22)10(13)5-24/h2-3,13,16-17,25H,1H3,(H,26,27)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant human c-Met protein (Invitrogen, Carlsbad, Calif., USA) is used. As substrate for the kinase reaction the peptide KKKSPGEYVNIEFG (JPT, Ge...


US Patent US9422263 (2016)


BindingDB Entry DOI: 10.7270/Q2JQ0ZW2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM240739
PNG
(US9422263, 20)
Show SMILES CC1=C(C#N)C(C(C#N)=C(N1)C(F)(F)F)c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C16H10F3N5/c1-8-11(5-20)14(12(6-21)15(23-8)16(17,18)19)9-2-3-13-10(4-9)7-22-24-13/h2-4,7,14,23H,1H3,(H,22,24)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant human c-Met protein (Invitrogen, Carlsbad, Calif., USA) is used. As substrate for the kinase reaction the peptide KKKSPGEYVNIEFG (JPT, Ge...


US Patent US9422263 (2016)


BindingDB Entry DOI: 10.7270/Q2JQ0ZW2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM240740
PNG
(US9422263, 24)
Show SMILES FC(F)C1=C(C#N)C(C(C#N)=C(N1)C(F)F)c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C16H9F4N5/c17-15(18)13-9(4-21)12(10(5-22)14(24-13)16(19)20)7-1-2-11-8(3-7)6-23-25-11/h1-3,6,12,15-16,24H,(H,23,25)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant human c-Met protein (Invitrogen, Carlsbad, Calif., USA) is used. As substrate for the kinase reaction the peptide KKKSPGEYVNIEFG (JPT, Ge...


US Patent US9422263 (2016)


BindingDB Entry DOI: 10.7270/Q2JQ0ZW2
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%