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Patent code US9422290

Compile Data Set for Download or QSAR
Found 38 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bromodomain protein 4 (BRD4-BD1)


(Homo sapiens (Human))
BDBM242713
PNG
(US9422290, III-2)
Show SMILES CCN1CCC(CC1)Nc1cc(nn2c(C)nnc12)N(C)Cc1ccccc1
Show InChI InChI=1S/C21H29N7/c1-4-27-12-10-18(11-13-27)22-19-14-20(25-28-16(2)23-24-21(19)28)26(3)15-17-8-6-5-7-9-17/h5-9,14,18,22H,4,10-13,15H2,1-3H3
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...


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More data for this
Ligand-Target Pair
Bromodomain protein 4 (BRD4-BD1)


(Homo sapiens (Human))
BDBM242688
PNG
(US9422290, I-1)
Show SMILES CN(Cc1ccccc1)c1cc(NC2CCN(C)CC2)c2nnc(C)n2n1
Show InChI InChI=1S/C20H27N7/c1-15-22-23-20-18(21-17-9-11-25(2)12-10-17)13-19(24-27(15)20)26(3)14-16-7-5-4-6-8-16/h4-8,13,17,21H,9-12,14H2,1-3H3
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain protein 4 (BRD4-BD1)


(Homo sapiens (Human))
BDBM242702
PNG
(US9422290, II-9)
Show SMILES CN1CCC(CC1)Nc1cc(nn2c(C)nnc12)-c1cn(C)nc1Cc1ccccc1
Show InChI InChI=1S/C23H28N8/c1-16-25-26-23-22(24-18-9-11-29(2)12-10-18)14-21(28-31(16)23)19-15-30(3)27-20(19)13-17-7-5-4-6-8-17/h4-8,14-15,18,24H,9-13H2,1-3H3
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain protein 4 (BRD4-BD1)


(Homo sapiens (Human))
BDBM242696
PNG
(US9422290, II-3)
Show SMILES CN1CCC(CC1)Nc1cc(nn2c(C)nnc12)-c1[nH]c2ccccc2c1Cc1ccccc1
Show InChI InChI=1S/C27H29N7/c1-18-30-31-27-25(28-20-12-14-33(2)15-13-20)17-24(32-34(18)27)26-22(16-19-8-4-3-5-9-19)21-10-6-7-11-23(21)29-26/h3-11,17,20,28-29H,12-16H2,1-2H3
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...


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More data for this
Ligand-Target Pair
Bromodomain protein 4 (BRD4-BD1)


(Homo sapiens (Human))
BDBM242714
PNG
(US9422290, III-3)
Show SMILES COCCN1CCC(CC1)Nc1cc(nn2c(C)nnc12)N(C)Cc1ccccc1
Show InChI InChI=1S/C22H31N7O/c1-17-24-25-22-20(23-19-9-11-28(12-10-19)13-14-30-3)15-21(26-29(17)22)27(2)16-18-7-5-4-6-8-18/h4-8,15,19,23H,9-14,16H2,1-3H3
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Boehringer Ingelheim International GmbH

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Assay Description
Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain protein 4 (BRD4-BD1)


(Homo sapiens (Human))
BDBM242701
PNG
(US9422290, II-8)
Show SMILES COCCN1CCC(CC1)Nc1cc(nn2c(C)nnc12)-c1cn(C)nc1Cc1ccccc1
Show InChI InChI=1S/C25H32N8O/c1-18-27-28-25-24(26-20-9-11-32(12-10-20)13-14-34-3)16-23(30-33(18)25)21-17-31(2)29-22(21)15-19-7-5-4-6-8-19/h4-8,16-17,20,26H,9-15H2,1-3H3
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Boehringer Ingelheim International GmbH

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Assay Description
Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...


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More data for this
Ligand-Target Pair
Bromodomain protein 4 (BRD4-BD1)


(Homo sapiens (Human))
BDBM242700
PNG
(US9422290, II-7)
Show SMILES CN1CCC(CC1)Nc1cc(nn2c(C)nnc12)-c1cnn(C)c1Oc1ccccc1
Show InChI InChI=1S/C22H26N8O/c1-15-25-26-21-20(24-16-9-11-28(2)12-10-16)13-19(27-30(15)21)18-14-23-29(3)22(18)31-17-7-5-4-6-8-17/h4-8,13-14,16,24H,9-12H2,1-3H3
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Boehringer Ingelheim International GmbH

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Assay Description
Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain protein 4 (BRD4-BD1)


(Homo sapiens (Human))
BDBM242699
PNG
(US9422290, II-6)
Show SMILES COCCN1CCC(CC1)Nc1cc(nn2c(C)nnc12)-c1cnn(C)c1Oc1ccccc1
Show InChI InChI=1S/C24H30N8O2/c1-17-27-28-23-22(26-18-9-11-31(12-10-18)13-14-33-3)15-21(29-32(17)23)20-16-25-30(2)24(20)34-19-7-5-4-6-8-19/h4-8,15-16,18,26H,9-14H2,1-3H3
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Assay Description
Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...


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More data for this
Ligand-Target Pair
Bromodomain protein 4 (BRD4-BD1)


(Homo sapiens (Human))
BDBM242694
PNG
(US9422290, II-1)
Show SMILES CN1CCC(CC1)Nc1cc(nn2c(C)nnc12)-c1cnn(C)c1Cc1ccccc1
Show InChI InChI=1S/C23H28N8/c1-16-26-27-23-21(25-18-9-11-29(2)12-10-18)14-20(28-31(16)23)19-15-24-30(3)22(19)13-17-7-5-4-6-8-17/h4-8,14-15,18,25H,9-13H2,1-3H3
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Assay Description
Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain protein 4 (BRD4-BD1)


(Homo sapiens (Human))
BDBM242691
PNG
(US9422290, I-4)
Show SMILES CN(Cc1ccccc1)c1cc(N[C@@H]2CCOC2)c2nnc(C)n2n1
Show InChI InChI=1S/C18H22N6O/c1-13-20-21-18-16(19-15-8-9-25-12-15)10-17(22-24(13)18)23(2)11-14-6-4-3-5-7-14/h3-7,10,15,19H,8-9,11-12H2,1-2H3/t15-/m1/s1
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Assay Description
Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain protein 4 (BRD4-BD1)


(Homo sapiens (Human))
BDBM242704
PNG
(US9422290, II-14)
Show SMILES CNc1cc(nn2c(C)nnc12)-c1cnn(C)c1Oc1ccccc1
Show InChI InChI=1S/C17H17N7O/c1-11-20-21-16-15(18-2)9-14(22-24(11)16)13-10-19-23(3)17(13)25-12-7-5-4-6-8-12/h4-10,18H,1-3H3
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Boehringer Ingelheim International GmbH

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Assay Description
Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...


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More data for this
Ligand-Target Pair
Bromodomain protein 4 (BRD4-BD1)


(Homo sapiens (Human))
BDBM242705
PNG
(US9422290, II-15)
Show SMILES CNc1cc(nn2c(C)nnc12)-c1cn(C)nc1Oc1ccccc1
Show InChI InChI=1S/C17H17N7O/c1-11-19-20-16-15(18-2)9-14(21-24(11)16)13-10-23(3)22-17(13)25-12-7-5-4-6-8-12/h4-10,18H,1-3H3
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Assay Description
Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain protein 4 (BRD4-BD1)


(Homo sapiens (Human))
BDBM242708
PNG
(US9422290, II-18)
Show SMILES CC(C)Nc1cc(nn2c(C)nnc12)-c1cn(C)nc1Oc1ccccc1
Show InChI InChI=1S/C19H21N7O/c1-12(2)20-17-10-16(23-26-13(3)21-22-18(17)26)15-11-25(4)24-19(15)27-14-8-6-5-7-9-14/h5-12,20H,1-4H3
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Assay Description
Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain protein 4 (BRD4-BD1)


(Homo sapiens (Human))
BDBM242687
PNG
(US9422290, III-6 | US9422290, III-8)
Show SMILES CN(Cc1ccccc1)c1cc(NC2CCN(CC2)S(=O)(=O)C2CCNC2)c2nnc(C)n2n1
Show InChI InChI=1S/C23H32N8O2S/c1-17-26-27-23-21(14-22(28-31(17)23)29(2)16-18-6-4-3-5-7-18)25-19-9-12-30(13-10-19)34(32,33)20-8-11-24-15-20/h3-7,14,19-20,24-25H,8-13,15-16H2,1-2H3
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Boehringer Ingelheim International GmbH

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Assay Description
Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain protein 4 (BRD4-BD1)


(Homo sapiens (Human))
BDBM242687
PNG
(US9422290, III-6 | US9422290, III-8)
Show SMILES CN(Cc1ccccc1)c1cc(NC2CCN(CC2)S(=O)(=O)C2CCNC2)c2nnc(C)n2n1
Show InChI InChI=1S/C23H32N8O2S/c1-17-26-27-23-21(14-22(28-31(17)23)29(2)16-18-6-4-3-5-7-18)25-19-9-12-30(13-10-19)34(32,33)20-8-11-24-15-20/h3-7,14,19-20,24-25H,8-13,15-16H2,1-2H3
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Boehringer Ingelheim International GmbH

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Assay Description
Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain protein 4 (BRD4-BD1)


(Homo sapiens (Human))
BDBM242686
PNG
(US9422290, III-5 | US9422290, III-7)
Show SMILES CN(C)CCCS(=O)(=O)N1CCC(CC1)Nc1cc(nn2c(C)nnc12)N(C)Cc1ccccc1
Show InChI InChI=1S/C24H36N8O2S/c1-19-26-27-24-22(17-23(28-32(19)24)30(4)18-20-9-6-5-7-10-20)25-21-11-14-31(15-12-21)35(33,34)16-8-13-29(2)3/h5-7,9-10,17,21,25H,8,11-16,18H2,1-4H3
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Assay Description
Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain protein 4 (BRD4-BD1)


(Homo sapiens (Human))
BDBM242697
PNG
(US9422290, II-4)
Show SMILES CN1CCC(CC1)Nc1cc(nn2c(C)nnc12)-c1c(Cc2ccccc2)c2ccccc2n1C
Show InChI InChI=1S/C28H31N7/c1-19-30-31-28-25(29-21-13-15-33(2)16-14-21)18-24(32-35(19)28)27-23(17-20-9-5-4-6-10-20)22-11-7-8-12-26(22)34(27)3/h4-12,18,21,29H,13-17H2,1-3H3
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Boehringer Ingelheim International GmbH

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Assay Description
Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain protein 4 (BRD4-BD1)


(Homo sapiens (Human))
BDBM242703
PNG
(US9422290, II-10)
Show SMILES CNc1cc(nn2c(C)nnc12)-c1cn(C)nc1Cc1ccccc1
Show InChI InChI=1S/C18H19N7/c1-12-20-21-18-17(19-2)10-16(23-25(12)18)14-11-24(3)22-15(14)9-13-7-5-4-6-8-13/h4-8,10-11,19H,9H2,1-3H3
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Boehringer Ingelheim International GmbH

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Assay Description
Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain protein 4 (BRD4-BD1)


(Homo sapiens (Human))
BDBM242720
PNG
(US9422290, III-11)
Show SMILES CN(Cc1ccccc1)c1cc(NC2CCN(CC2)S(=O)(=O)C2CCN(C)CC2)c2nnc(C)n2n1
Show InChI InChI=1S/C25H36N8O2S/c1-19-27-28-25-23(17-24(29-33(19)25)31(3)18-20-7-5-4-6-8-20)26-21-9-15-32(16-10-21)36(34,35)22-11-13-30(2)14-12-22/h4-8,17,21-22,26H,9-16,18H2,1-3H3
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Assay Description
Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain protein 4 (BRD4-BD1)


(Homo sapiens (Human))
BDBM242715
PNG
(US9422290, III-4)
Show SMILES CN(Cc1ccccc1)c1cc(NC2CCN(CC2)C=O)c2nnc(C)n2n1
Show InChI InChI=1S/C20H25N7O/c1-15-22-23-20-18(21-17-8-10-26(14-28)11-9-17)12-19(24-27(15)20)25(2)13-16-6-4-3-5-7-16/h3-7,12,14,17,21H,8-11,13H2,1-2H3
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Assay Description
Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain protein 4 (BRD4-BD1)


(Homo sapiens (Human))
BDBM242718
PNG
(US9422290, III-9)
Show SMILES CN(Cc1ccccc1)c1cc(NC2CCN(CC2)S(=O)(=O)C2CCNCC2)c2nnc(C)n2n1
Show InChI InChI=1S/C24H34N8O2S/c1-18-27-28-24-22(16-23(29-32(18)24)30(2)17-19-6-4-3-5-7-19)26-20-10-14-31(15-11-20)35(33,34)21-8-12-25-13-9-21/h3-7,16,20-21,25-26H,8-15,17H2,1-2H3
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Boehringer Ingelheim International GmbH

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Assay Description
Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain protein 4 (BRD4-BD1)


(Homo sapiens (Human))
BDBM242710
PNG
(US9422290, II-20)
Show SMILES CC(C)Nc1cc(nn2c(C)nnc12)-c1cn(C)nc1Oc1ccccn1
Show InChI InChI=1S/C18H20N8O/c1-11(2)20-15-9-14(23-26-12(3)21-22-17(15)26)13-10-25(4)24-18(13)27-16-7-5-6-8-19-16/h5-11,20H,1-4H3
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Assay Description
Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain protein 4 (BRD4-BD1)


(Homo sapiens (Human))
BDBM242719
PNG
(US9422290, III-10)
Show SMILES CN(Cc1ccccc1)c1cc(NC2CCN(CC2)S(=O)(=O)CCN)c2nnc(C)n2n1
Show InChI InChI=1S/C21H30N8O2S/c1-16-24-25-21-19(23-18-8-11-28(12-9-18)32(30,31)13-10-22)14-20(26-29(16)21)27(2)15-17-6-4-3-5-7-17/h3-7,14,18,23H,8-13,15,22H2,1-2H3
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Assay Description
Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...


Citation and Details
More data for this
Ligand-Target Pair
Bromodomain protein 4 (BRD4-BD1)


(Homo sapiens (Human))
BDBM242684
PNG
(US9422290, II-12)
Show SMILES Cc1nnc2c(Cl)cc(nn12)-c1cn(C)nc1Cc1ccccc1
Show InChI InChI=1S/C17H15ClN6/c1-11-19-20-17-14(18)9-16(22-24(11)17)13-10-23(2)21-15(13)8-12-6-4-3-5-7-12/h3-7,9-10H,8H2,1-2H3
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Boehringer Ingelheim International GmbH

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Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...


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Ligand-Target Pair
Bromodomain protein 4 (BRD4-BD1)


(Homo sapiens (Human))
BDBM242686
PNG
(US9422290, III-5 | US9422290, III-7)
Show SMILES CN(C)CCCS(=O)(=O)N1CCC(CC1)Nc1cc(nn2c(C)nnc12)N(C)Cc1ccccc1
Show InChI InChI=1S/C24H36N8O2S/c1-19-26-27-24-22(17-23(28-32(19)24)30(4)18-20-9-6-5-7-10-20)25-21-11-14-31(15-12-21)35(33,34)16-8-13-29(2)3/h5-7,9-10,17,21,25H,8,11-16,18H2,1-4H3
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Boehringer Ingelheim International GmbH

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Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...


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More data for this
Ligand-Target Pair
Bromodomain protein 4 (BRD4-BD1)


(Homo sapiens (Human))
BDBM242712
PNG
(US9422290, III-1)
Show SMILES CN(Cc1ccccc1)c1cc(NC2CCN(CC2)C(C)=O)c2nnc(C)n2n1
Show InChI InChI=1S/C21H27N7O/c1-15-23-24-21-19(22-18-9-11-27(12-10-18)16(2)29)13-20(25-28(15)21)26(3)14-17-7-5-4-6-8-17/h4-8,13,18,22H,9-12,14H2,1-3H3
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Boehringer Ingelheim International GmbH

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Assay Description
Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...


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More data for this
Ligand-Target Pair
Bromodomain protein 4 (BRD4-BD1)


(Homo sapiens (Human))
BDBM242683
PNG
(US9422290, II-11)
Show SMILES Cc1nnc2c(C)cc(nn12)-c1cn(C)nc1Cc1ccccc1
Show InChI InChI=1S/C18H18N6/c1-12-9-16(22-24-13(2)19-20-18(12)24)15-11-23(3)21-17(15)10-14-7-5-4-6-8-14/h4-9,11H,10H2,1-3H3
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Boehringer Ingelheim International GmbH

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Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...


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More data for this
Ligand-Target Pair
Bromodomain protein 4 (BRD4-BD1)


(Homo sapiens (Human))
BDBM242690
PNG
(US9422290, I-3)
Show SMILES CN(Cc1ccccc1)c1cc(N[C@H]2CCOC2)c2nnc(C)n2n1
Show InChI InChI=1S/C18H22N6O/c1-13-20-21-18-16(19-15-8-9-25-12-15)10-17(22-24(13)18)23(2)11-14-6-4-3-5-7-14/h3-7,10,15,19H,8-9,11-12H2,1-2H3/t15-/m0/s1
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Boehringer Ingelheim International GmbH

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Assay Description
Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...


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More data for this
Ligand-Target Pair
Bromodomain protein 4 (BRD4-BD1)


(Homo sapiens (Human))
BDBM242711
PNG
(US9422290, II-21)
Show SMILES CNc1cc(nn2c(C)nnc12)-c1cn(C)nc1Oc1ccccn1
Show InChI InChI=1S/C16H16N8O/c1-10-19-20-15-13(17-2)8-12(21-24(10)15)11-9-23(3)22-16(11)25-14-6-4-5-7-18-14/h4-9,17H,1-3H3
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Assay Description
Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...


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More data for this
Ligand-Target Pair
Bromodomain protein 4 (BRD4-BD1)


(Homo sapiens (Human))
BDBM242693
PNG
(US9422290, I-6)
Show SMILES CNc1cc(nn2c(C)nnc12)N(C)Cc1ccc(F)cc1
Show InChI InChI=1S/C15H17FN6/c1-10-18-19-15-13(17-2)8-14(20-22(10)15)21(3)9-11-4-6-12(16)7-5-11/h4-8,17H,9H2,1-3H3
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Boehringer Ingelheim International GmbH

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Assay Description
Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...


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More data for this
Ligand-Target Pair
Bromodomain protein 4 (BRD4-BD1)


(Homo sapiens (Human))
BDBM242692
PNG
(US9422290, I-5)
Show SMILES CNc1cc(nn2c(C)nnc12)N(C)Cc1ccccc1
Show InChI InChI=1S/C15H18N6/c1-11-17-18-15-13(16-2)9-14(19-21(11)15)20(3)10-12-7-5-4-6-8-12/h4-9,16H,10H2,1-3H3
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Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...


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More data for this
Ligand-Target Pair
Bromodomain protein 4 (BRD4-BD1)


(Homo sapiens (Human))
BDBM242689
PNG
(US9422290, I-2)
Show SMILES CN(Cc1ccccc1)c1cc(NC2CCOCC2)c2nnc(C)n2n1
Show InChI InChI=1S/C19H24N6O/c1-14-21-22-19-17(20-16-8-10-26-11-9-16)12-18(23-25(14)19)24(2)13-15-6-4-3-5-7-15/h3-7,12,16,20H,8-11,13H2,1-2H3
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Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...


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More data for this
Ligand-Target Pair
Bromodomain protein 4 (BRD4-BD1)


(Homo sapiens (Human))
BDBM242709
PNG
(US9422290, II-19)
Show SMILES CC(C)Nc1cc(nn2c(C)nnc12)-c1cn(C)nc1Cc1ccccc1
Show InChI InChI=1S/C20H23N7/c1-13(2)21-19-11-18(25-27-14(3)22-23-20(19)27)16-12-26(4)24-17(16)10-15-8-6-5-7-9-15/h5-9,11-13,21H,10H2,1-4H3
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Assay Description
Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...


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More data for this
Ligand-Target Pair
Bromodomain protein 4 (BRD4-BD1)


(Homo sapiens (Human))
BDBM242698
PNG
(US9422290, II-5)
Show SMILES CN1CCC(CC1)Nc1cc(nn2c(C)nnc12)-c1cc2ccccc2n1Cc1ccccc1
Show InChI InChI=1S/C27H29N7/c1-19-29-30-27-24(28-22-12-14-32(2)15-13-22)17-23(31-34(19)27)26-16-21-10-6-7-11-25(21)33(26)18-20-8-4-3-5-9-20/h3-11,16-17,22,28H,12-15,18H2,1-2H3
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Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...


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More data for this
Ligand-Target Pair
Bromodomain protein 4 (BRD4-BD1)


(Homo sapiens (Human))
BDBM242695
PNG
(US9422290, II-2)
Show SMILES CN1CCC(CC1)Nc1cc(nn2c(C)nnc12)-c1ccnn1Cc1ccccc1
Show InChI InChI=1S/C22H26N8/c1-16-25-26-22-20(24-18-9-12-28(2)13-10-18)14-19(27-30(16)22)21-8-11-23-29(21)15-17-6-4-3-5-7-17/h3-8,11,14,18,24H,9-10,12-13,15H2,1-2H3
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Boehringer Ingelheim International GmbH

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Assay Description
Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...


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More data for this
Ligand-Target Pair
Bromodomain protein 4 (BRD4-BD1)


(Homo sapiens (Human))
BDBM242707
PNG
(US9422290, II-17)
Show SMILES CC(C)Nc1cc(nn2c(C)nnc12)-c1cnn(C)c1Oc1ccccc1
Show InChI InChI=1S/C19H21N7O/c1-12(2)21-17-10-16(24-26-13(3)22-23-18(17)26)15-11-20-25(4)19(15)27-14-8-6-5-7-9-14/h5-12,21H,1-4H3
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Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...


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More data for this
Ligand-Target Pair
Bromodomain protein 4 (BRD4-BD1)


(Homo sapiens (Human))
BDBM242706
PNG
(US9422290, II-16)
Show SMILES CC(C)Nc1cc(nn2c(C)nnc12)-c1cn(nc1Cc1ccccc1)C(C)C
Show InChI InChI=1S/C22H27N7/c1-14(2)23-21-12-20(27-29-16(5)24-25-22(21)29)18-13-28(15(3)4)26-19(18)11-17-9-7-6-8-10-17/h6-10,12-15,23H,11H2,1-5H3
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Boehringer Ingelheim International GmbH

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Assay Description
Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...


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More data for this
Ligand-Target Pair
Bromodomain protein 4 (BRD4-BD1)


(Homo sapiens (Human))
BDBM242685
PNG
(US9422290, II-13)
Show SMILES CSc1cc(nn2c(C)nnc12)-c1cn(C)nc1Cc1ccccc1
Show InChI InChI=1S/C18H18N6S/c1-12-19-20-18-17(25-3)10-16(22-24(12)18)14-11-23(2)21-15(14)9-13-7-5-4-6-8-13/h4-8,10-11H,9H2,1-3H3
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Boehringer Ingelheim International GmbH

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Assay Description
Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...


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Ligand-Target Pair
* indicates data uncertainty>20%