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Patent code US9422293

Compile Data Set for Download or QSAR

Found 771 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM245007
PNG
(US9422293, 244)
Show SMILES CC1CCCN1c1nc2CCN(CCc2c(Nc2ccc(cc2)C(F)(F)F)n1)c1ncccc1C(F)(F)F
Show InChI InChI=1S/C26H26F6N6/c1-16-4-3-13-38(16)24-35-21-11-15-37(23-20(26(30,31)32)5-2-12-33-23)14-10-19(21)22(36-24)34-18-8-6-17(7-9-18)25(27,28)29/h2,5-9,12,16H,3-4,10-11,13-15H2,1H3,(H,34,35,36)
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n/an/a 2n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM245009
PNG
(US9422293, 246 | US9422293, 276 | US9422293, 277)
Show SMILES CC1CCCCN1c1nc2CCN(CCc2c(Nc2ccc(cc2)C(F)(F)F)n1)c1ncccc1C(F)(F)F
Show InChI InChI=1S/C27H28F6N6/c1-17-5-2-3-14-39(17)25-36-22-12-16-38(24-21(27(31,32)33)6-4-13-34-24)15-11-20(22)23(37-25)35-19-9-7-18(8-10-19)26(28,29)30/h4,6-10,13,17H,2-3,5,11-12,14-16H2,1H3,(H,35,36,37)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM245118
PNG
(US9422293, 362)
Show SMILES CC(O)CSc1nc2CCN(CCc2c(Nc2ccc(cc2)S(=O)(=O)C(F)(F)F)n1)c1ncccc1C(F)(F)F
Show InChI InChI=1S/C24H23F6N5O3S2/c1-14(36)13-39-22-33-19-9-12-35(21-18(23(25,26)27)3-2-10-31-21)11-8-17(19)20(34-22)32-15-4-6-16(7-5-15)40(37,38)24(28,29)30/h2-7,10,14,36H,8-9,11-13H2,1H3,(H,32,33,34)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50331116
PNG
(2-morpholino-N-(4-(trifluoromethyl)phenyl)-7-(3-(t...)
Show SMILES FC(F)(F)c1ccc(Nc2nc(nc3CCN(CCc23)c2ncccc2C(F)(F)F)N2CCOCC2)cc1
Show InChI InChI=1S/C25H24F6N6O/c26-24(27,28)16-3-5-17(6-4-16)33-21-18-7-10-36(22-19(25(29,30)31)2-1-9-32-22)11-8-20(18)34-23(35-21)37-12-14-38-15-13-37/h1-6,9H,7-8,10-15H2,(H,33,34,35)
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n/an/a 3.70n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...


Citation and Details
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM245130
PNG
(US9422293, 374)
Show SMILES CC1OCCC1Sc1nc2CCN(CCc2c(Nc2ccc3c(c2)N(C)CCC3(C)C)n1)c1ncccc1C(F)(F)F
Show InChI InChI=1S/C31H37F3N6OS/c1-19-26(11-17-41-19)42-29-37-24-10-15-40(28-23(31(32,33)34)6-5-13-35-28)14-9-21(24)27(38-29)36-20-7-8-22-25(18-20)39(4)16-12-30(22,2)3/h5-8,13,18-19,26H,9-12,14-17H2,1-4H3,(H,36,37,38)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The assay was performed as described below, using HEK293 cells transfected with rat TRPV1 (rTRPV1/HEK293). These cells had a geneticin selection mark...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM244931
PNG
(US9422293, 159)
Show SMILES CC(C)(C)c1ccc(Nc2nc(nc3CCN(CCc23)c2ncccc2C(F)(F)F)N2CCCCC2)cc1[N+]([O-])=O
Show InChI InChI=1S/C29H34F3N7O2/c1-28(2,3)21-10-9-19(18-24(21)39(40)41)34-25-20-11-16-37(26-22(29(30,31)32)8-7-13-33-26)17-12-23(20)35-27(36-25)38-14-5-4-6-15-38/h7-10,13,18H,4-6,11-12,14-17H2,1-3H3,(H,34,35,36)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM244930
PNG
(US9422293, 157)
Show SMILES Fc1cc(Nc2nc(nc3CCN(CCc23)c2ncccc2C(F)(F)F)N2CCCCC2)ccc1C(F)(F)F
Show InChI InChI=1S/C26H25F7N6/c27-20-15-16(6-7-18(20)25(28,29)30)35-22-17-8-13-38(23-19(26(31,32)33)5-4-10-34-23)14-9-21(17)36-24(37-22)39-11-2-1-3-12-39/h4-7,10,15H,1-3,8-9,11-14H2,(H,35,36,37)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM245076
PNG
(US9422293, 320)
Show SMILES CC(Oc1nc2CCN(CCc2c(Nc2ccc(cc2)S(=O)(=O)N2CCCC2)n1)c1ncccc1C(F)(F)F)C1CCCCC1
Show InChI InChI=1S/C32H39F3N6O3S/c1-22(23-8-3-2-4-9-23)44-31-38-28-16-21-40(30-27(32(33,34)35)10-7-17-36-30)20-15-26(28)29(39-31)37-24-11-13-25(14-12-24)45(42,43)41-18-5-6-19-41/h7,10-14,17,22-23H,2-6,8-9,15-16,18-21H2,1H3,(H,37,38,39)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50331116
PNG
(2-morpholino-N-(4-(trifluoromethyl)phenyl)-7-(3-(t...)
Show SMILES FC(F)(F)c1ccc(Nc2nc(nc3CCN(CCc23)c2ncccc2C(F)(F)F)N2CCOCC2)cc1
Show InChI InChI=1S/C25H24F6N6O/c26-24(27,28)16-3-5-17(6-4-16)33-21-18-7-10-36(22-19(25(29,30)31)2-1-9-32-22)11-8-20(18)34-23(35-21)37-12-14-38-15-13-37/h1-6,9H,7-8,10-15H2,(H,33,34,35)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50331115
PNG
(2-(pyrrolidin-1-yl)-N-(4-(trifluoromethyl)phenyl)-...)
Show SMILES FC(F)(F)c1ccc(Nc2nc(nc3CCN(CCc23)c2ncccc2C(F)(F)F)N2CCCC2)cc1
Show InChI InChI=1S/C25H24F6N6/c26-24(27,28)16-5-7-17(8-6-16)33-21-18-9-14-36(22-19(25(29,30)31)4-3-11-32-22)15-10-20(18)34-23(35-21)37-12-1-2-13-37/h3-8,11H,1-2,9-10,12-15H2,(H,33,34,35)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM244803
PNG
(US9422293, 6)
Show SMILES CC(C)(C)c1ccc(Nc2nc(nc3CCN(CCc23)c2ncccc2C(F)(F)F)-c2ccccc2)cc1
Show InChI InChI=1S/C30H30F3N5/c1-29(2,3)21-11-13-22(14-12-21)35-27-23-15-18-38(28-24(30(31,32)33)10-7-17-34-28)19-16-25(23)36-26(37-27)20-8-5-4-6-9-20/h4-14,17H,15-16,18-19H2,1-3H3,(H,35,36,37)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM244829
PNG
(US9422293, 39 and 39A)
Show SMILES FC(F)(F)c1ccc(Nc2nc(nc3CCN(CCc23)c2ncccc2C(F)(F)F)N2CCCCC2)cc1
Show InChI InChI=1S/C26H26F6N6/c27-25(28,29)17-6-8-18(9-7-17)34-22-19-10-15-37(23-20(26(30,31)32)5-4-12-33-23)16-11-21(19)35-24(36-22)38-13-2-1-3-14-38/h4-9,12H,1-3,10-11,13-16H2,(H,34,35,36)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM244835
PNG
(US9422293, 47)
Show SMILES CC(C)(C)c1ccc(Nc2nc(nc3CCN(CCc23)c2ncccc2C(F)(F)F)N2CCOCC2)cc1
Show InChI InChI=1S/C28H33F3N6O/c1-27(2,3)19-6-8-20(9-7-19)33-24-21-10-13-36(25-22(28(29,30)31)5-4-12-32-25)14-11-23(21)34-26(35-24)37-15-17-38-18-16-37/h4-9,12H,10-11,13-18H2,1-3H3,(H,33,34,35)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM244876
PNG
(US9422293, 93B)
Show SMILES COCCN(C)c1nc2CCN(CCc2c(Nc2ccc(cc2)C(F)(F)F)n1)c1ncccc1C(F)(F)F
Show InChI InChI=1S/C25H26F6N6O/c1-36(14-15-38-2)23-34-20-10-13-37(22-19(25(29,30)31)4-3-11-32-22)12-9-18(20)21(35-23)33-17-7-5-16(6-8-17)24(26,27)28/h3-8,11H,9-10,12-15H2,1-2H3,(H,33,34,35)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM244829
PNG
(US9422293, 39 and 39A)
Show SMILES FC(F)(F)c1ccc(Nc2nc(nc3CCN(CCc23)c2ncccc2C(F)(F)F)N2CCCCC2)cc1
Show InChI InChI=1S/C26H26F6N6/c27-25(28,29)17-6-8-18(9-7-17)34-22-19-10-15-37(23-20(26(30,31)32)5-4-12-33-23)16-11-21(19)35-24(36-22)38-13-2-1-3-14-38/h4-9,12H,1-3,10-11,13-16H2,(H,34,35,36)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM244979
PNG
(US9422293, 214)
Show SMILES COC1CCCN(C1)c1nc2CCN(CCc2c(Nc2ccc(cc2)C(F)(F)F)n1)c1ncccc1C(F)(F)F
Show InChI InChI=1S/C27H28F6N6O/c1-40-19-4-3-13-39(16-19)25-36-22-11-15-38(24-21(27(31,32)33)5-2-12-34-24)14-10-20(22)23(37-25)35-18-8-6-17(7-9-18)26(28,29)30/h2,5-9,12,19H,3-4,10-11,13-16H2,1H3,(H,35,36,37)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...


Citation and Details
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM244979
PNG
(US9422293, 214)
Show SMILES COC1CCCN(C1)c1nc2CCN(CCc2c(Nc2ccc(cc2)C(F)(F)F)n1)c1ncccc1C(F)(F)F
Show InChI InChI=1S/C27H28F6N6O/c1-40-19-4-3-13-39(16-19)25-36-22-11-15-38(24-21(27(31,32)33)5-2-12-34-24)14-10-20(22)23(37-25)35-18-8-6-17(7-9-18)26(28,29)30/h2,5-9,12,19H,3-4,10-11,13-16H2,1H3,(H,35,36,37)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The assay was performed as described below, using HEK293 cells transfected with rat TRPV1 (rTRPV1/HEK293). These cells had a geneticin selection mark...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM245004
PNG
(US9422293, 241)
Show SMILES FC(F)(F)c1ccc(Nc2nc(nc3CCN(CCc23)c2ncccc2C(F)(F)F)N2CC(F)(F)C2)cc1
Show InChI InChI=1S/C24H20F8N6/c25-22(26)12-38(13-22)21-35-18-8-11-37(20-17(24(30,31)32)2-1-9-33-20)10-7-16(18)19(36-21)34-15-5-3-14(4-6-15)23(27,28)29/h1-6,9H,7-8,10-13H2,(H,34,35,36)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...


Citation and Details
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM244980
PNG
(US9422293, 215)
Show SMILES COC[C@@H]1CCCN1c1nc2CCN(CCc2c(Nc2ccc(cc2)C(F)(F)F)n1)c1ncccc1C(F)(F)F
Show InChI InChI=1S/C27H28F6N6O/c1-40-16-19-4-3-13-39(19)25-36-22-11-15-38(24-21(27(31,32)33)5-2-12-34-24)14-10-20(22)23(37-25)35-18-8-6-17(7-9-18)26(28,29)30/h2,5-9,12,19H,3-4,10-11,13-16H2,1H3,(H,35,36,37)/t19-/m0/s1
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Janssen Pharmaceutica NV

US Patent


Assay Description
The assay was performed as described below, using HEK293 cells transfected with rat TRPV1 (rTRPV1/HEK293). These cells had a geneticin selection mark...


Citation and Details
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM245014
PNG
(US9422293, 253)
Show SMILES CC(C)(C)c1ccc(Nc2nc(nc3CCN(CCc23)c2ncccc2C(F)(F)F)N2CCCCCC2)cc1
Show InChI InChI=1S/C30H37F3N6/c1-29(2,3)21-10-12-22(13-11-21)35-26-23-14-19-38(27-24(30(31,32)33)9-8-16-34-27)20-15-25(23)36-28(37-26)39-17-6-4-5-7-18-39/h8-13,16H,4-7,14-15,17-20H2,1-3H3,(H,35,36,37)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The assay was performed as described below, using HEK293 cells transfected with rat TRPV1 (rTRPV1/HEK293). These cells had a geneticin selection mark...


Citation and Details
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM245124
PNG
(US9422293, 368 | US9422293, 369)
Show SMILES CC1OCCC1Sc1nc2CCN(CCc2c(Nc2ccc(cc2C)C(F)(F)F)n1)c1ncccc1C(F)(F)F
Show InChI InChI=1S/C27H27F6N5OS/c1-15-14-17(26(28,29)30)5-6-20(15)35-23-18-7-11-38(24-19(27(31,32)33)4-3-10-34-24)12-8-21(18)36-25(37-23)40-22-9-13-39-16(22)2/h3-6,10,14,16,22H,7-9,11-13H2,1-2H3,(H,35,36,37)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The assay was performed as described below, using HEK293 cells transfected with rat TRPV1 (rTRPV1/HEK293). These cells had a geneticin selection mark...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM244986
PNG
(US9422293, 222)
Show SMILES FC(F)(F)c1ccc(Nc2nc(nc3CCN(CCc23)c2ncccc2C(F)(F)F)N2CCCCCC2)cc1
Show InChI InChI=1S/C27H28F6N6/c28-26(29,30)18-7-9-19(10-8-18)35-23-20-11-16-38(24-21(27(31,32)33)6-5-13-34-24)17-12-22(20)36-25(37-23)39-14-3-1-2-4-15-39/h5-10,13H,1-4,11-12,14-17H2,(H,35,36,37)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM245003
PNG
(US9422293, 240)
Show SMILES CC1CCCN(C1)c1nc2CCN(CCc2c(Nc2ccc(cc2)C(F)(F)F)n1)c1ncccc1C(F)(F)F
Show InChI InChI=1S/C27H28F6N6/c1-17-4-3-13-39(16-17)25-36-22-11-15-38(24-21(27(31,32)33)5-2-12-34-24)14-10-20(22)23(37-25)35-19-8-6-18(7-9-19)26(28,29)30/h2,5-9,12,17H,3-4,10-11,13-16H2,1H3,(H,35,36,37)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM245110
PNG
(US9422293, 354)
Show SMILES FC(F)(F)c1ccc(Nc2nc(SC3CCCCC3)nc3CCN(CCc23)c2ncccc2C(F)(F)F)cc1
Show InChI InChI=1S/C27H27F6N5S/c28-26(29,30)17-8-10-18(11-9-17)35-23-20-12-15-38(24-21(27(31,32)33)7-4-14-34-24)16-13-22(20)36-25(37-23)39-19-5-2-1-3-6-19/h4,7-11,14,19H,1-3,5-6,12-13,15-16H2,(H,35,36,37)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM244999
PNG
(US9422293, 236)
Show SMILES C[C@H]1CN(C[C@@H](C)O1)c1nc2CCN(CCc2c(Nc2ccc(cc2)C(F)(F)F)n1)c1ncccc1C(F)(F)F
Show InChI InChI=1S/C27H28F6N6O/c1-16-14-39(15-17(2)40-16)25-36-22-10-13-38(24-21(27(31,32)33)4-3-11-34-24)12-9-20(22)23(37-25)35-19-7-5-18(6-8-19)26(28,29)30/h3-8,11,16-17H,9-10,12-15H2,1-2H3,(H,35,36,37)/t16-,17+
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM245014
PNG
(US9422293, 253)
Show SMILES CC(C)(C)c1ccc(Nc2nc(nc3CCN(CCc23)c2ncccc2C(F)(F)F)N2CCCCCC2)cc1
Show InChI InChI=1S/C30H37F3N6/c1-29(2,3)21-10-12-22(13-11-21)35-26-23-14-19-38(27-24(30(31,32)33)9-8-16-34-27)20-15-25(23)36-28(37-26)39-17-6-4-5-7-18-39/h8-13,16H,4-7,14-15,17-20H2,1-3H3,(H,35,36,37)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM245063
PNG
(US9422293, 307 | US9422293, 330)
Show SMILES CC1(C)OCC(COc2nc3CCN(CCc3c(Nc3ccc(cc3)C(F)(F)F)n2)c2ncccc2C(F)(F)F)O1
Show InChI InChI=1S/C27H27F6N5O3/c1-25(2)40-15-18(41-25)14-39-24-36-21-10-13-38(23-20(27(31,32)33)4-3-11-34-23)12-9-19(21)22(37-24)35-17-7-5-16(6-8-17)26(28,29)30/h3-8,11,18H,9-10,12-15H2,1-2H3,(H,35,36,37)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...


Citation and Details
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM244999
PNG
(US9422293, 236)
Show SMILES C[C@H]1CN(C[C@@H](C)O1)c1nc2CCN(CCc2c(Nc2ccc(cc2)C(F)(F)F)n1)c1ncccc1C(F)(F)F
Show InChI InChI=1S/C27H28F6N6O/c1-16-14-39(15-17(2)40-16)25-36-22-10-13-38(24-21(27(31,32)33)4-3-11-34-24)12-9-20(22)23(37-25)35-19-7-5-18(6-8-19)26(28,29)30/h3-8,11,16-17H,9-10,12-15H2,1-2H3,(H,35,36,37)/t16-,17+
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Janssen Pharmaceutica NV

US Patent


Assay Description
The assay was performed as described below, using HEK293 cells transfected with rat TRPV1 (rTRPV1/HEK293). These cells had a geneticin selection mark...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM244987
PNG
(US9422293, 223)
Show SMILES FC(F)(F)c1ccc(Nc2nc(nc3CCN(CCc23)c2ncccc2C(F)(F)F)N2CCCCCC2)cn1
Show InChI InChI=1S/C26H27F6N7/c27-25(28,29)19-6-5-11-33-23(19)38-14-9-18-20(10-15-38)36-24(39-12-3-1-2-4-13-39)37-22(18)35-17-7-8-21(34-16-17)26(30,31)32/h5-8,11,16H,1-4,9-10,12-15H2,(H,35,36,37)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM245000
PNG
(US9422293, 237)
Show SMILES FC(F)(F)c1ccc(Nc2nc(nc3CCN(CCc23)c2ncccc2C(F)(F)F)N2CCCOCC2)cc1
Show InChI InChI=1S/C26H26F6N6O/c27-25(28,29)17-4-6-18(7-5-17)34-22-19-8-12-37(23-20(26(30,31)32)3-1-10-33-23)13-9-21(19)35-24(36-22)38-11-2-15-39-16-14-38/h1,3-7,10H,2,8-9,11-16H2,(H,34,35,36)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM245005
PNG
(US9422293, 242)
Show SMILES FC(F)(F)c1ccc(Nc2nc(nc3CCN(CCc23)c2ncccc2C(F)(F)F)N2CCC(F)(F)CC2)cc1
Show InChI InChI=1S/C26H24F8N6/c27-24(28)9-14-40(15-10-24)23-37-20-8-13-39(22-19(26(32,33)34)2-1-11-35-22)12-7-18(20)21(38-23)36-17-5-3-16(4-6-17)25(29,30)31/h1-6,11H,7-10,12-15H2,(H,36,37,38)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM245008
PNG
(US9422293, 245)
Show SMILES FC(F)(F)c1ccc(Nc2nc(nc3CCN(CCc23)c2ncccc2C(F)(F)F)N2CCCOCC2)cc1Cl
Show InChI InChI=1S/C26H25ClF6N6O/c27-20-15-16(4-5-18(20)25(28,29)30)35-22-17-6-10-38(23-19(26(31,32)33)3-1-8-34-23)11-7-21(17)36-24(37-22)39-9-2-13-40-14-12-39/h1,3-5,8,15H,2,6-7,9-14H2,(H,35,36,37)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM245088
PNG
(US9422293, 332)
Show SMILES CC(Oc1nc2CCN(CCc2c(Nc2ccc(cc2)C(F)(F)F)n1)c1ncccc1C(F)(F)F)C1CCCCC1
Show InChI InChI=1S/C29H31F6N5O/c1-18(19-6-3-2-4-7-19)41-27-38-24-14-17-40(26-23(29(33,34)35)8-5-15-36-26)16-13-22(24)25(39-27)37-21-11-9-20(10-12-21)28(30,31)32/h5,8-12,15,18-19H,2-4,6-7,13-14,16-17H2,1H3,(H,37,38,39)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM245109
PNG
(US9422293, 353)
Show SMILES FC(F)(F)c1ccc(Nc2nc(SCc3ccccc3)nc3CCN(CCc23)c2ncccc2C(F)(F)F)cc1
Show InChI InChI=1S/C28H23F6N5S/c29-27(30,31)19-8-10-20(11-9-19)36-24-21-12-15-39(25-22(28(32,33)34)7-4-14-35-25)16-13-23(21)37-26(38-24)40-17-18-5-2-1-3-6-18/h1-11,14H,12-13,15-17H2,(H,36,37,38)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM245119
PNG
(US9422293, 363)
Show SMILES CC1OCCC1Sc1nc2CCN(CCc2c(Nc2ccc(cc2)S(=O)(=O)C(F)(F)F)n1)c1ncccc1C(F)(F)F
Show InChI InChI=1S/C26H25F6N5O3S2/c1-15-21(10-14-40-15)41-24-35-20-9-13-37(23-19(25(27,28)29)3-2-11-33-23)12-8-18(20)22(36-24)34-16-4-6-17(7-5-16)42(38,39)26(30,31)32/h2-7,11,15,21H,8-10,12-14H2,1H3,(H,34,35,36)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM245136
PNG
(US9422293, 381)
Show SMILES FC(F)(F)c1ccc(Nc2nc(nc3CCN(CCc23)c2ncccc2C(F)(F)F)N2CCOCC2)cc1Cl
Show InChI InChI=1S/C25H23ClF6N6O/c26-19-14-15(3-4-17(19)24(27,28)29)34-21-16-5-8-37(22-18(25(30,31)32)2-1-7-33-22)9-6-20(16)35-23(36-21)38-10-12-39-13-11-38/h1-4,7,14H,5-6,8-13H2,(H,34,35,36)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM245141
PNG
(US9422293, 390)
Show SMILES FC(F)(F)c1ccc(Nc2nc(nc3CCN(CCc23)c2ncccc2C(F)(F)F)N2CCCCC2)nc1Cl
Show InChI InChI=1S/C25H24ClF6N7/c26-20-16(24(27,28)29)6-7-19(35-20)36-21-15-8-13-38(22-17(25(30,31)32)5-4-10-33-22)14-9-18(15)34-23(37-21)39-11-2-1-3-12-39/h4-7,10H,1-3,8-9,11-14H2,(H,34,35,36,37)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...


Citation and Details
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM245000
PNG
(US9422293, 237)
Show SMILES FC(F)(F)c1ccc(Nc2nc(nc3CCN(CCc23)c2ncccc2C(F)(F)F)N2CCCOCC2)cc1
Show InChI InChI=1S/C26H26F6N6O/c27-25(28,29)17-4-6-18(7-5-17)34-22-19-8-12-37(23-20(26(30,31)32)3-1-10-33-23)13-9-21(19)35-24(36-22)38-11-2-15-39-16-14-38/h1,3-7,10H,2,8-9,11-16H2,(H,34,35,36)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The assay was performed as described below, using HEK293 cells transfected with rat TRPV1 (rTRPV1/HEK293). These cells had a geneticin selection mark...


Citation and Details
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM245078
PNG
(US9422293, 322)
Show SMILES FC(F)(F)c1cccnc1N1CCc2nc(OC3CCOCC3)nc(Nc3ccc(cc3)S(=O)(=O)C(F)(F)F)c2CC1
Show InChI InChI=1S/C26H25F6N5O4S/c27-25(28,29)20-2-1-11-33-23(20)37-12-7-19-21(8-13-37)35-24(41-17-9-14-40-15-10-17)36-22(19)34-16-3-5-18(6-4-16)42(38,39)26(30,31)32/h1-6,11,17H,7-10,12-15H2,(H,34,35,36)
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Janssen Pharmaceutica NV

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Assay Description
The assay was performed as described below, using HEK293 cells transfected with rat TRPV1 (rTRPV1/HEK293). These cells had a geneticin selection mark...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM244809
PNG
(US9422293, 14)
Show SMILES CC(C)c1nc2CCN(CCc2c(NCc2ccc(Cl)c(Cl)c2)n1)c1ncccc1C(F)(F)F
Show InChI InChI=1S/C24H24Cl2F3N5/c1-14(2)21-32-20-8-11-34(23-17(24(27,28)29)4-3-9-30-23)10-7-16(20)22(33-21)31-13-15-5-6-18(25)19(26)12-15/h3-6,9,12,14H,7-8,10-11,13H2,1-2H3,(H,31,32,33)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM244998
PNG
(US9422293, 235)
Show SMILES CC1CN(CC(C)O1)c1nc2CCN(CCc2c(Nc2ccc(cc2)C(F)(F)F)n1)c1ncccc1C(F)(F)F
Show InChI InChI=1S/C27H28F6N6O/c1-16-14-39(15-17(2)40-16)25-36-22-10-13-38(24-21(27(31,32)33)4-3-11-34-24)12-9-20(22)23(37-25)35-19-7-5-18(6-8-19)26(28,29)30/h3-8,11,16-17H,9-10,12-15H2,1-2H3,(H,35,36,37)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...


Citation and Details
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM244998
PNG
(US9422293, 235)
Show SMILES CC1CN(CC(C)O1)c1nc2CCN(CCc2c(Nc2ccc(cc2)C(F)(F)F)n1)c1ncccc1C(F)(F)F
Show InChI InChI=1S/C27H28F6N6O/c1-16-14-39(15-17(2)40-16)25-36-22-10-13-38(24-21(27(31,32)33)4-3-11-34-24)12-9-20(22)23(37-25)35-19-7-5-18(6-8-19)26(28,29)30/h3-8,11,16-17H,9-10,12-15H2,1-2H3,(H,35,36,37)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The assay was performed as described below, using HEK293 cells transfected with rat TRPV1 (rTRPV1/HEK293). These cells had a geneticin selection mark...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM245009
PNG
(US9422293, 246 | US9422293, 276 | US9422293, 277)
Show SMILES CC1CCCCN1c1nc2CCN(CCc2c(Nc2ccc(cc2)C(F)(F)F)n1)c1ncccc1C(F)(F)F
Show InChI InChI=1S/C27H28F6N6/c1-17-5-2-3-14-39(17)25-36-22-12-16-38(24-21(27(31,32)33)6-4-13-34-24)15-11-20(22)23(37-25)35-19-9-7-18(8-10-19)26(28,29)30/h4,6-10,13,17H,2-3,5,11-12,14-16H2,1H3,(H,35,36,37)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...


Citation and Details
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM245007
PNG
(US9422293, 244)
Show SMILES CC1CCCN1c1nc2CCN(CCc2c(Nc2ccc(cc2)C(F)(F)F)n1)c1ncccc1C(F)(F)F
Show InChI InChI=1S/C26H26F6N6/c1-16-4-3-13-38(16)24-35-21-11-15-37(23-20(26(30,31)32)5-2-12-33-23)14-10-19(21)22(36-24)34-18-8-6-17(7-9-18)25(27,28)29/h2,5-9,12,16H,3-4,10-11,13-15H2,1H3,(H,34,35,36)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The assay was performed as described below, using HEK293 cells transfected with rat TRPV1 (rTRPV1/HEK293). These cells had a geneticin selection mark...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM245089
PNG
(US9422293, 333)
Show SMILES FC(F)(F)c1cccnc1N1CCc2nc(OC3CCCC3)nc(Nc3ccc(cc3)S(=O)(=O)N3CCCC3)c2CC1
Show InChI InChI=1S/C29H33F3N6O3S/c30-29(31,32)24-8-5-15-33-27(24)37-18-13-23-25(14-19-37)35-28(41-21-6-1-2-7-21)36-26(23)34-20-9-11-22(12-10-20)42(39,40)38-16-3-4-17-38/h5,8-12,15,21H,1-4,6-7,13-14,16-19H2,(H,34,35,36)
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Janssen Pharmaceutica NV

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Assay Description
HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM244988
PNG
(US9422293, 224)
Show SMILES FC(F)(F)c1ccc(Nc2nc(nc3CCN(CCc23)c2ncccc2C(F)(F)F)N2CCCCCC2)cc1Cl
Show InChI InChI=1S/C27H27ClF6N6/c28-21-16-17(7-8-19(21)26(29,30)31)36-23-18-9-14-39(24-20(27(32,33)34)6-5-11-35-24)15-10-22(18)37-25(38-23)40-12-3-1-2-4-13-40/h5-8,11,16H,1-4,9-10,12-15H2,(H,36,37,38)
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Janssen Pharmaceutica NV

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Assay Description
HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...


Citation and Details
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM244823
PNG
(US9422293, 32)
Show SMILES Cc1nc2ccccc2nc1N1CCc2ncnc(Nc3ccc(cc3)C(C)(C)C)c2CC1
Show InChI InChI=1S/C27H30N6/c1-18-26(32-24-8-6-5-7-23(24)30-18)33-15-13-21-22(14-16-33)28-17-29-25(21)31-20-11-9-19(10-12-20)27(2,3)4/h5-12,17H,13-16H2,1-4H3,(H,28,29,31)
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Janssen Pharmaceutica NV

US Patent


Assay Description
The assay was performed as described below, using HEK293 cells transfected with rat TRPV1 (rTRPV1/HEK293). These cells had a geneticin selection mark...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50331157
PNG
(CHEMBL1290704 | N-(4-tert-butylphenyl)-7-(3-(trifl...)
Show SMILES CC(C)(C)c1ccc(Nc2ncnc3CCN(CCc23)c2ncccc2C(F)(F)F)cc1
Show InChI InChI=1S/C24H26F3N5/c1-23(2,3)16-6-8-17(9-7-16)31-21-18-10-13-32(14-11-20(18)29-15-30-21)22-19(24(25,26)27)5-4-12-28-22/h4-9,12,15H,10-11,13-14H2,1-3H3,(H,29,30,31)
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Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...


Citation and Details
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM244836
PNG
(US9422293, 48)
Show SMILES CN(C)c1nc2CCN(CCc2c(Nc2ccc(cc2)C(C)(C)C)n1)c1ncccc1C(F)(F)F
Show InChI InChI=1S/C26H31F3N6/c1-25(2,3)17-8-10-18(11-9-17)31-22-19-12-15-35(16-13-21(19)32-24(33-22)34(4)5)23-20(26(27,28)29)7-6-14-30-23/h6-11,14H,12-13,15-16H2,1-5H3,(H,31,32,33)
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Assay Description
HEK293 cells were transfected with human TRPV1 cloned in pcDNA3.1zeo(+) using the Effectene non-liposomal lipid based transfection kit (Qiagen) (hTRP...


Citation and Details
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM244829
PNG
(US9422293, 39 and 39A)
Show SMILES FC(F)(F)c1ccc(Nc2nc(nc3CCN(CCc23)c2ncccc2C(F)(F)F)N2CCCCC2)cc1
Show InChI InChI=1S/C26H26F6N6/c27-25(28,29)17-6-8-18(9-7-17)34-22-19-10-15-37(23-20(26(30,31)32)5-4-12-33-23)16-11-21(19)35-24(36-22)38-13-2-1-3-14-38/h4-9,12H,1-3,10-11,13-16H2,(H,34,35,36)
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Assay Description
The assay was performed as described below, using HEK293 cells transfected with rat TRPV1 (rTRPV1/HEK293). These cells had a geneticin selection mark...


Citation and Details
More data for this
Ligand-Target Pair
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