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Patent code US9422307

Compile Data Set for Download or QSAR
Found 17 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM240752
PNG
(US9422307, 15)
Show SMILES COc1cc(Nc2nc(N)c3scc(-c4cccc(NC(=O)C5CC5)c4)c3n2)cc(OC)c1OC
Show InChI InChI=1S/C25H25N5O4S/c1-32-18-10-16(11-19(33-2)21(18)34-3)28-25-29-20-17(12-35-22(20)23(26)30-25)14-5-4-6-15(9-14)27-24(31)13-7-8-13/h4-6,9-13H,7-8H2,1-3H3,(H,27,31)(H3,26,28,29,30)
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n/an/a<1.00E+4n/an/an/an/an/an/a



KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

US Patent


Assay Description
Full sequence FAK was purchased from Cell Signaling (Catalog No.: 7796). ULight-poly GT (PerkinElmer #TRF0100-D), Eu-anti-phospho-Tyr (PT66) (PerkinE...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM240762
PNG
(US9422307, 46)
Show SMILES C=Cc1csc2c(NCc3ccccc3)nc(NCCN3CCOCC3)nc12
Show InChI InChI=1S/C21H25N5OS/c1-2-17-15-28-19-18(17)24-21(22-8-9-26-10-12-27-13-11-26)25-20(19)23-14-16-6-4-3-5-7-16/h2-7,15H,1,8-14H2,(H2,22,23,24,25)
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n/an/a<1.00E+4n/an/an/an/an/an/a



KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

US Patent


Assay Description
Full sequence FAK was purchased from Cell Signaling (Catalog No.: 7796). ULight-poly GT (PerkinElmer #TRF0100-D), Eu-anti-phospho-Tyr (PT66) (PerkinE...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM240749
PNG
(US9422307, 3)
Show SMILES CNC(=O)c1cccc(c1)-c1csc2c(N)nc(Nc3ccc(cc3)N3CCC(O)CC3)nc12
Show InChI InChI=1S/C25H26N6O2S/c1-27-24(33)16-4-2-3-15(13-16)20-14-34-22-21(20)29-25(30-23(22)26)28-17-5-7-18(8-6-17)31-11-9-19(32)10-12-31/h2-8,13-14,19,32H,9-12H2,1H3,(H,27,33)(H3,26,28,29,30)
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n/an/a<1.00E+4n/an/an/an/an/an/a



KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

US Patent


Assay Description
Full sequence FAK was purchased from Cell Signaling (Catalog No.: 7796). ULight-poly GT (PerkinElmer #TRF0100-D), Eu-anti-phospho-Tyr (PT66) (PerkinE...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM240750
PNG
(US9422307, 6)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2nc(N)c3scc(-c4cccc(c4)C(=O)NC)c3n2)cc1
Show InChI InChI=1S/C26H29N7OS/c1-3-32-11-13-33(14-12-32)20-9-7-19(8-10-20)29-26-30-22-21(16-35-23(22)24(27)31-26)17-5-4-6-18(15-17)25(34)28-2/h4-10,15-16H,3,11-14H2,1-2H3,(H,28,34)(H3,27,29,30,31)
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n/an/a<1.00E+4n/an/an/an/an/an/a



KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

US Patent


Assay Description
Full sequence FAK was purchased from Cell Signaling (Catalog No.: 7796). ULight-poly GT (PerkinElmer #TRF0100-D), Eu-anti-phospho-Tyr (PT66) (PerkinE...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM240763
PNG
(US9422307, 47)
Show SMILES C[C@@H](Nc1nc(NCCN2CCOCC2)nc2c(C=C)csc12)c1ccccc1
Show InChI InChI=1S/C22H27N5OS/c1-3-17-15-29-20-19(17)25-22(23-9-10-27-11-13-28-14-12-27)26-21(20)24-16(2)18-7-5-4-6-8-18/h3-8,15-16H,1,9-14H2,2H3,(H2,23,24,25,26)/t16-/m1/s1
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n/an/a<1.00E+4n/an/an/an/an/an/a



KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

US Patent


Assay Description
Full sequence FAK was purchased from Cell Signaling (Catalog No.: 7796). ULight-poly GT (PerkinElmer #TRF0100-D), Eu-anti-phospho-Tyr (PT66) (PerkinE...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM240755
PNG
(US9422307, 27)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2nc(N)c3scc(-c4cccc(NS(C)(=O)=O)c4)c3n2)cn1
Show InChI InChI=1S/C24H28N8O2S2/c1-3-31-9-11-32(12-10-31)20-8-7-18(14-26-20)27-24-28-21-19(15-35-22(21)23(25)29-24)16-5-4-6-17(13-16)30-36(2,33)34/h4-8,13-15,30H,3,9-12H2,1-2H3,(H3,25,27,28,29)
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n/an/a<1.00E+4n/an/an/an/an/an/a



KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

US Patent


Assay Description
Full sequence FAK was purchased from Cell Signaling (Catalog No.: 7796). ULight-poly GT (PerkinElmer #TRF0100-D), Eu-anti-phospho-Tyr (PT66) (PerkinE...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM240756
PNG
(US9422307, 39)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2nc(N)c3scc(-c4cnc5ccccc5c4)c3n2)cn1
Show InChI InChI=1S/C26H26N8S/c1-2-33-9-11-34(12-10-33)22-8-7-19(15-29-22)30-26-31-23-20(16-35-24(23)25(27)32-26)18-13-17-5-3-4-6-21(17)28-14-18/h3-8,13-16H,2,9-12H2,1H3,(H3,27,30,31,32)
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n/an/a<1.00E+4n/an/an/an/an/an/a



KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

US Patent


Assay Description
Full sequence FAK was purchased from Cell Signaling (Catalog No.: 7796). ULight-poly GT (PerkinElmer #TRF0100-D), Eu-anti-phospho-Tyr (PT66) (PerkinE...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM240764
PNG
(US9422307, 48)
Show SMILES CCc1csc2c(NCc3ccccc3)nc(NCCN3CCOCC3)nc12
Show InChI InChI=1S/C21H27N5OS/c1-2-17-15-28-19-18(17)24-21(22-8-9-26-10-12-27-13-11-26)25-20(19)23-14-16-6-4-3-5-7-16/h3-7,15H,2,8-14H2,1H3,(H2,22,23,24,25)
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n/an/a<1.00E+4n/an/an/an/an/an/a



KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

US Patent


Assay Description
Full sequence FAK was purchased from Cell Signaling (Catalog No.: 7796). ULight-poly GT (PerkinElmer #TRF0100-D), Eu-anti-phospho-Tyr (PT66) (PerkinE...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM240751
PNG
(US9422307, 7)
Show SMILES CNC(=O)c1cccc(c1)-c1csc2c(N)nc(Nc3ccc(cc3)N3CCC(CC3)N3CCCC3)nc12
Show InChI InChI=1S/C29H33N7OS/c1-31-28(37)20-6-4-5-19(17-20)24-18-38-26-25(24)33-29(34-27(26)30)32-21-7-9-22(10-8-21)36-15-11-23(12-16-36)35-13-2-3-14-35/h4-10,17-18,23H,2-3,11-16H2,1H3,(H,31,37)(H3,30,32,33,34)
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n/an/a<1.00E+4n/an/an/an/an/an/a



KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

US Patent


Assay Description
Full sequence FAK was purchased from Cell Signaling (Catalog No.: 7796). ULight-poly GT (PerkinElmer #TRF0100-D), Eu-anti-phospho-Tyr (PT66) (PerkinE...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM240761
PNG
(US9422307, 45)
Show SMILES C[C@H](O)CNc1nc(N[C@H](C)c2ccccc2)c2scc(C#C)c2n1
Show InChI InChI=1S/C19H20N4OS/c1-4-14-11-25-17-16(14)22-19(20-10-12(2)24)23-18(17)21-13(3)15-8-6-5-7-9-15/h1,5-9,11-13,24H,10H2,2-3H3,(H2,20,21,22,23)/t12-,13+/m0/s1
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n/an/a<1.00E+4n/an/an/an/an/an/a



KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

US Patent


Assay Description
Full sequence FAK was purchased from Cell Signaling (Catalog No.: 7796). ULight-poly GT (PerkinElmer #TRF0100-D), Eu-anti-phospho-Tyr (PT66) (PerkinE...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM240754
PNG
(US9422307, 26)
Show SMILES CNS(=O)(=O)c1cccc(c1)-c1csc2c(N)nc(Nc3cc(OC)c(OC)c(OC)c3)nc12
Show InChI InChI=1S/C22H23N5O5S2/c1-24-34(28,29)14-7-5-6-12(8-14)15-11-33-20-18(15)26-22(27-21(20)23)25-13-9-16(30-2)19(32-4)17(10-13)31-3/h5-11,24H,1-4H3,(H3,23,25,26,27)
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n/an/a<1.00E+4n/an/an/an/an/an/a



KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

US Patent


Assay Description
Full sequence FAK was purchased from Cell Signaling (Catalog No.: 7796). ULight-poly GT (PerkinElmer #TRF0100-D), Eu-anti-phospho-Tyr (PT66) (PerkinE...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM240758
PNG
(US9422307, 42)
Show SMILES Nc1nc(Nc2ccc(nc2)N2CCOCC2)nc2c(csc12)-c1cnc2ccccc2c1
Show InChI InChI=1S/C24H21N7OS/c25-23-22-21(18(14-33-22)16-11-15-3-1-2-4-19(15)26-12-16)29-24(30-23)28-17-5-6-20(27-13-17)31-7-9-32-10-8-31/h1-6,11-14H,7-10H2,(H3,25,28,29,30)
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n/an/a<1.00E+4n/an/an/an/an/an/a



KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

US Patent


Assay Description
Full sequence FAK was purchased from Cell Signaling (Catalog No.: 7796). ULight-poly GT (PerkinElmer #TRF0100-D), Eu-anti-phospho-Tyr (PT66) (PerkinE...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM240748
PNG
(US9422307, 2)
Show SMILES CNC(=O)c1cccc(c1)-c1csc2c(N)nc(Nc3ccc(nc3)N3CCOCC3)nc12
Show InChI InChI=1S/C23H23N7O2S/c1-25-22(31)15-4-2-3-14(11-15)17-13-33-20-19(17)28-23(29-21(20)24)27-16-5-6-18(26-12-16)30-7-9-32-10-8-30/h2-6,11-13H,7-10H2,1H3,(H,25,31)(H3,24,27,28,29)
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n/an/a<1.00E+4n/an/an/an/an/an/a



KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

US Patent


Assay Description
Full sequence FAK was purchased from Cell Signaling (Catalog No.: 7796). ULight-poly GT (PerkinElmer #TRF0100-D), Eu-anti-phospho-Tyr (PT66) (PerkinE...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM240753
PNG
(US9422307, 17)
Show SMILES CCS(=O)(=O)Nc1cccc(c1)-c1csc2c(N)nc(Nc3cc(OC)c(OC)c(OC)c3)nc12
Show InChI InChI=1S/C23H25N5O5S2/c1-5-35(29,30)28-14-8-6-7-13(9-14)16-12-34-21-19(16)26-23(27-22(21)24)25-15-10-17(31-2)20(33-4)18(11-15)32-3/h6-12,28H,5H2,1-4H3,(H3,24,25,26,27)
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n/an/a<1.00E+4n/an/an/an/an/an/a



KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

US Patent


Assay Description
Full sequence FAK was purchased from Cell Signaling (Catalog No.: 7796). ULight-poly GT (PerkinElmer #TRF0100-D), Eu-anti-phospho-Tyr (PT66) (PerkinE...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM240759
PNG
(US9422307, 43)
Show SMILES CCN1CCN(CC1)c1cccc(Nc2nc(N)c3scc(-c4cnc5ccccc5c4)c3n2)c1
Show InChI InChI=1S/C27H27N7S/c1-2-33-10-12-34(13-11-33)21-8-5-7-20(15-21)30-27-31-24-22(17-35-25(24)26(28)32-27)19-14-18-6-3-4-9-23(18)29-16-19/h3-9,14-17H,2,10-13H2,1H3,(H3,28,30,31,32)
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n/an/a<1.00E+4n/an/an/an/an/an/a



KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

US Patent


Assay Description
Full sequence FAK was purchased from Cell Signaling (Catalog No.: 7796). ULight-poly GT (PerkinElmer #TRF0100-D), Eu-anti-phospho-Tyr (PT66) (PerkinE...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM240760
PNG
(US9422307, 44)
Show SMILES C[C@H](O)CNc1nc(NCc2ccccc2)c2scc(C#C)c2n1
Show InChI InChI=1S/C18H18N4OS/c1-3-14-11-24-16-15(14)21-18(20-9-12(2)23)22-17(16)19-10-13-7-5-4-6-8-13/h1,4-8,11-12,23H,9-10H2,2H3,(H2,19,20,21,22)/t12-/m0/s1
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n/an/a<1.00E+4n/an/an/an/an/an/a



KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

US Patent


Assay Description
Full sequence FAK was purchased from Cell Signaling (Catalog No.: 7796). ULight-poly GT (PerkinElmer #TRF0100-D), Eu-anti-phospho-Tyr (PT66) (PerkinE...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM240757
PNG
(US9422307, 41)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2nc(N)c3scc(-c4cnc5ccccc5c4)c3n2)cc1
Show InChI InChI=1S/C27H27N7S/c1-2-33-11-13-34(14-12-33)21-9-7-20(8-10-21)30-27-31-24-22(17-35-25(24)26(28)32-27)19-15-18-5-3-4-6-23(18)29-16-19/h3-10,15-17H,2,11-14H2,1H3,(H3,28,30,31,32)
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n/an/a<1.00E+4n/an/an/an/an/an/a



KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

US Patent


Assay Description
Full sequence FAK was purchased from Cell Signaling (Catalog No.: 7796). ULight-poly GT (PerkinElmer #TRF0100-D), Eu-anti-phospho-Tyr (PT66) (PerkinE...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%