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Patent code US9422332

Compile Data Set for Download or QSAR
Found 92 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
XIAP protein BIR2


(Artificial Sequence)
BDBM242836
PNG
(US9422332, 21)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1cccc2ccccc12
Show InChI InChI=1S/C28H32N4O3/c1-17(2)24(31-26(33)18(3)29-4)28(35)32-16-20-11-6-8-14-22(20)25(32)27(34)30-23-15-9-12-19-10-5-7-13-21(19)23/h5-15,17-18,24-25,29H,16H2,1-4H3,(H,30,34)(H,31,33)/t18-,24-,25-/m0/s1
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n/an/a 5n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR2


(Artificial Sequence)
BDBM242850
PNG
(US9422332, 10)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C25H30F2N4O3/c1-5-14(2)20(29-23(32)15(3)28-4)25(34)31-13-16-9-6-7-10-17(16)22(31)24(33)30-21-18(26)11-8-12-19(21)27/h6-12,14-15,20,22,28H,5,13H2,1-4H3,(H,29,32)(H,30,33)/t14-,15-,20-,22-/m0/s1
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n/an/a 6n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR2


(Artificial Sequence)
BDBM242829
PNG
(US9422332, 4)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1CCc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1Cl
Show InChI InChI=1S/C25H30ClFN4O3/c1-14(2)20(29-23(32)15(3)28-4)25(34)31-13-12-16-8-5-6-9-17(16)22(31)24(33)30-21-18(26)10-7-11-19(21)27/h5-11,14-15,20,22,28H,12-13H2,1-4H3,(H,29,32)(H,30,33)/t15-,20-,22-/m0/s1
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n/an/a 6n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR2


(Artificial Sequence)
BDBM242832
PNG
(US9422332, 7)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1c(Cl)cccc1Cl
Show InChI InChI=1S/C24H28Cl2N4O3/c1-13(2)19(28-22(31)14(3)27-4)24(33)30-12-15-8-5-6-9-16(15)21(30)23(32)29-20-17(25)10-7-11-18(20)26/h5-11,13-14,19,21,27H,12H2,1-4H3,(H,28,31)(H,29,32)/t14-,19-,21-/m0/s1
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n/an/a 9n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR2


(Artificial Sequence)
BDBM242827
PNG
(US9422332, 2)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C1CCCCC1)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C27H32F2N4O3/c1-16(30-2)25(34)31-22(17-9-4-3-5-10-17)27(36)33-15-18-11-6-7-12-19(18)24(33)26(35)32-23-20(28)13-8-14-21(23)29/h6-8,11-14,16-17,22,24,30H,3-5,9-10,15H2,1-2H3,(H,31,34)(H,32,35)/t16-,22-,24-/m0/s1
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n/an/a 9n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR2


(Artificial Sequence)
BDBM242833
PNG
(US9422332, 8)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1Cl
Show InChI InChI=1S/C24H28ClFN4O3/c1-13(2)19(28-22(31)14(3)27-4)24(33)30-12-15-8-5-6-9-16(15)21(30)23(32)29-20-17(25)10-7-11-18(20)26/h5-11,13-14,19,21,27H,12H2,1-4H3,(H,28,31)(H,29,32)/t14-,19-,21-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR2


(Artificial Sequence)
BDBM242826
PNG
(US9422332, 1)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C24H28F2N4O3/c1-13(2)19(28-22(31)14(3)27-4)24(33)30-12-15-8-5-6-9-16(15)21(30)23(32)29-20-17(25)10-7-11-18(20)26/h5-11,13-14,19,21,27H,12H2,1-4H3,(H,28,31)(H,29,32)/t14-,19-,21-/m0/s1
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n/an/a 12n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR2


(Artificial Sequence)
BDBM242860
PNG
(US9422332, 15)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC)C(=O)N1CCc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C26H32F2N4O3/c1-5-15(2)21(30-24(33)16(3)29-4)26(35)32-14-13-17-9-6-7-10-18(17)23(32)25(34)31-22-19(27)11-8-12-20(22)28/h6-12,15-16,21,23,29H,5,13-14H2,1-4H3,(H,30,33)(H,31,34)/t15-,16-,21-,23-/m0/s1
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n/an/a 13n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR2


(Artificial Sequence)
BDBM242851
PNG
(US9422332, 11)
Show SMILES CN[C@@H](C)C(=O)N[C@H](C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F)C(C)(C)C
Show InChI InChI=1S/C25H30F2N4O3/c1-14(28-5)22(32)30-21(25(2,3)4)24(34)31-13-15-9-6-7-10-16(15)20(31)23(33)29-19-17(26)11-8-12-18(19)27/h6-12,14,20-21,28H,13H2,1-5H3,(H,29,33)(H,30,32)/t14-,20-,21+/m0/s1
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n/an/a 13n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR2


(Artificial Sequence)
BDBM242852
PNG
(US9422332, 12)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C1CCOCC1)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C26H30F2N4O4/c1-15(29-2)24(33)30-21(16-10-12-36-13-11-16)26(35)32-14-17-6-3-4-7-18(17)23(32)25(34)31-22-19(27)8-5-9-20(22)28/h3-9,15-16,21,23,29H,10-14H2,1-2H3,(H,30,33)(H,31,34)/t15-,21-,23-/m0/s1
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n/an/a 14n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR2


(Artificial Sequence)
BDBM242855
PNG
(US9422332, 33)
Show SMILES CN[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C23H26F2N4O4/c1-12(26-3)21(31)27-18(13(2)30)23(33)29-11-14-7-4-5-8-15(14)20(29)22(32)28-19-16(24)9-6-10-17(19)25/h4-10,12-13,18,20,26,30H,11H2,1-3H3,(H,27,31)(H,28,32)/t12-,13+,18-,20-/m0/s1
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n/an/a 16n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR2


(Artificial Sequence)
BDBM242859
PNG
(US9422332, 14)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C1CCOCC1)C(=O)N1CCc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C27H32F2N4O4/c1-16(30-2)25(34)31-22(18-11-14-37-15-12-18)27(36)33-13-10-17-6-3-4-7-19(17)24(33)26(35)32-23-20(28)8-5-9-21(23)29/h3-9,16,18,22,24,30H,10-15H2,1-2H3,(H,31,34)(H,32,35)/t16-,22-,24-/m0/s1
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n/an/a 16n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR2


(Artificial Sequence)
BDBM242844
PNG
(US9422332, 47)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1c(C)cccc1F
Show InChI InChI=1S/C25H31FN4O3/c1-14(2)20(28-23(31)16(4)27-5)25(33)30-13-17-10-6-7-11-18(17)22(30)24(32)29-21-15(3)9-8-12-19(21)26/h6-12,14,16,20,22,27H,13H2,1-5H3,(H,28,31)(H,29,32)/t16-,20-,22-/m0/s1
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n/an/a 19n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR2


(Artificial Sequence)
BDBM242830
PNG
(US9422332, 5)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1CCc2cc(Cl)ccc2[C@H]1C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C25H29ClF2N4O3/c1-13(2)20(30-23(33)14(3)29-4)25(35)32-11-10-15-12-16(26)8-9-17(15)22(32)24(34)31-21-18(27)6-5-7-19(21)28/h5-9,12-14,20,22,29H,10-11H2,1-4H3,(H,30,33)(H,31,34)/t14-,20-,22-/m0/s1
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n/an/a 21n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR2


(Artificial Sequence)
BDBM242840
PNG
(US9422332, 26)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1ccccc1Cl
Show InChI InChI=1S/C24H29ClN4O3/c1-14(2)20(28-22(30)15(3)26-4)24(32)29-13-16-9-5-6-10-17(16)21(29)23(31)27-19-12-8-7-11-18(19)25/h5-12,14-15,20-21,26H,13H2,1-4H3,(H,27,31)(H,28,30)/t15-,20-,21-/m0/s1
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n/an/a 21n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR2


(Artificial Sequence)
BDBM242839
PNG
(US9422332, 24)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1ccccc1F
Show InChI InChI=1S/C24H29FN4O3/c1-14(2)20(28-22(30)15(3)26-4)24(32)29-13-16-9-5-6-10-17(16)21(29)23(31)27-19-12-8-7-11-18(19)25/h5-12,14-15,20-21,26H,13H2,1-4H3,(H,27,31)(H,28,30)/t15-,20-,21-/m0/s1
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n/an/a 22n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR2


(Artificial Sequence)
BDBM242853
PNG
(US9422332, 13)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C1CCCC1)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C26H30F2N4O3/c1-15(29-2)24(33)30-21(16-8-3-4-9-16)26(35)32-14-17-10-5-6-11-18(17)23(32)25(34)31-22-19(27)12-7-13-20(22)28/h5-7,10-13,15-16,21,23,29H,3-4,8-9,14H2,1-2H3,(H,30,33)(H,31,34)/t15-,21-,23-/m0/s1
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n/an/a 23n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR2


(Artificial Sequence)
BDBM242854
PNG
(US9422332, 32)
Show SMILES CN[C@@H](C)C(=O)N[C@@H]([C@@H](C)OC)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C24H28F2N4O4/c1-13(27-3)22(31)28-19(14(2)34-4)24(33)30-12-15-8-5-6-9-16(15)21(30)23(32)29-20-17(25)10-7-11-18(20)26/h5-11,13-14,19,21,27H,12H2,1-4H3,(H,28,31)(H,29,32)/t13-,14+,19-,21-/m0/s1
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n/an/a 24n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR2


(Artificial Sequence)
BDBM242831
PNG
(US9422332, 6)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1CCc2cc(F)ccc2[C@H]1C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C25H29F3N4O3/c1-13(2)20(30-23(33)14(3)29-4)25(35)32-11-10-15-12-16(26)8-9-17(15)22(32)24(34)31-21-18(27)6-5-7-19(21)28/h5-9,12-14,20,22,29H,10-11H2,1-4H3,(H,30,33)(H,31,34)/t14-,20-,22-/m0/s1
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n/an/a 25n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR2


(Artificial Sequence)
BDBM242865
PNG
(US9422332, 36)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1CCc2ccccc2[C@H]1C(=O)Nc1c(Cl)cccc1Cl
Show InChI InChI=1S/C25H30Cl2N4O3/c1-14(2)20(29-23(32)15(3)28-4)25(34)31-13-12-16-8-5-6-9-17(16)22(31)24(33)30-21-18(26)10-7-11-19(21)27/h5-11,14-15,20,22,28H,12-13H2,1-4H3,(H,29,32)(H,30,33)/t15-,20-,22-/m0/s1
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n/an/a 25n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR2


(Artificial Sequence)
BDBM242828
PNG
(US9422332, 3)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C1CCCCC1)C(=O)N1CCc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C28H34F2N4O3/c1-17(31-2)26(35)32-23(19-10-4-3-5-11-19)28(37)34-16-15-18-9-6-7-12-20(18)25(34)27(36)33-24-21(29)13-8-14-22(24)30/h6-9,12-14,17,19,23,25,31H,3-5,10-11,15-16H2,1-2H3,(H,32,35)(H,33,36)/t17-,23-,25-/m0/s1
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n/an/a 26n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR2


(Artificial Sequence)
BDBM242857
PNG
(US9422332, 35)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C25H30F2N4O3/c1-14(2)12-20(29-23(32)15(3)28-4)25(34)31-13-16-8-5-6-9-17(16)22(31)24(33)30-21-18(26)10-7-11-19(21)27/h5-11,14-15,20,22,28H,12-13H2,1-4H3,(H,29,32)(H,30,33)/t15-,20-,22-/m0/s1
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n/an/a 27n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR2


(Artificial Sequence)
BDBM242870
PNG
(US9422332, 42)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1CCc2ccc(F)cc2[C@H]1C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C25H29F3N4O3/c1-13(2)20(30-23(33)14(3)29-4)25(35)32-11-10-15-8-9-16(26)12-17(15)22(32)24(34)31-21-18(27)6-5-7-19(21)28/h5-9,12-14,20,22,29H,10-11H2,1-4H3,(H,30,33)(H,31,34)/t14-,20-,22-/m0/s1
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n/an/a 27n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR2


(Artificial Sequence)
BDBM242861
PNG
(US9422332, 25)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1CCc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C25H30F2N4O3/c1-14(2)20(29-23(32)15(3)28-4)25(34)31-13-12-16-8-5-6-9-17(16)22(31)24(33)30-21-18(26)10-7-11-19(21)27/h5-11,14-15,20,22,28H,12-13H2,1-4H3,(H,29,32)(H,30,33)/t15-,20-,22-/m0/s1
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n/an/a 27n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR2


(Artificial Sequence)
BDBM242856
PNG
(US9422332, 34)
Show SMILES CN[C@@H](C)C(=O)N[C@H](C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F)c1ccccc1
Show InChI InChI=1S/C27H26F2N4O3/c1-16(30-2)25(34)31-22(17-9-4-3-5-10-17)27(36)33-15-18-11-6-7-12-19(18)24(33)26(35)32-23-20(28)13-8-14-21(23)29/h3-14,16,22,24,30H,15H2,1-2H3,(H,31,34)(H,32,35)/t16-,22-,24-/m0/s1
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n/an/a 32n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR2


(Artificial Sequence)
BDBM242862
PNG
(US9422332, 37)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C1CCCC1)C(=O)N1CCc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C27H32F2N4O3/c1-16(30-2)25(34)31-22(18-9-3-4-10-18)27(36)33-15-14-17-8-5-6-11-19(17)24(33)26(35)32-23-20(28)12-7-13-21(23)29/h5-8,11-13,16,18,22,24,30H,3-4,9-10,14-15H2,1-2H3,(H,31,34)(H,32,35)/t16-,22-,24-/m0/s1
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n/an/a 34n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR2


(Artificial Sequence)
BDBM242872
PNG
(US9422332, 31)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2C[C@H]1C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C25H30F2N4O3/c1-14(2)21(29-23(32)15(3)28-4)25(34)31-13-17-9-6-5-8-16(17)12-20(31)24(33)30-22-18(26)10-7-11-19(22)27/h5-11,14-15,20-21,28H,12-13H2,1-4H3,(H,29,32)(H,30,33)/t15-,20-,21-/m0/s1
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n/an/a 37n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR2


(Artificial Sequence)
BDBM242843
PNG
(US9422332, 30)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1cccc2n(C)ccc12
Show InChI InChI=1S/C27H33N5O3/c1-16(2)23(30-25(33)17(3)28-4)27(35)32-15-18-9-6-7-10-19(18)24(32)26(34)29-21-11-8-12-22-20(21)13-14-31(22)5/h6-14,16-17,23-24,28H,15H2,1-5H3,(H,29,34)(H,30,33)/t17-,23-,24-/m0/s1
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n/an/a 40n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR2


(Artificial Sequence)
BDBM242834
PNG
(US9422332, 9)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1cccc2sccc12
Show InChI InChI=1S/C26H30N4O3S/c1-15(2)22(29-24(31)16(3)27-4)26(33)30-14-17-8-5-6-9-18(17)23(30)25(32)28-20-10-7-11-21-19(20)12-13-34-21/h5-13,15-16,22-23,27H,14H2,1-4H3,(H,28,32)(H,29,31)/t16-,22-,23-/m0/s1
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n/an/a 43n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR2


(Artificial Sequence)
BDBM242867
PNG
(US9422332, 45)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1CCc2ccc(Cl)cc2[C@H]1C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C25H29ClF2N4O3/c1-13(2)20(30-23(33)14(3)29-4)25(35)32-11-10-15-8-9-16(26)12-17(15)22(32)24(34)31-21-18(27)6-5-7-19(21)28/h5-9,12-14,20,22,29H,10-11H2,1-4H3,(H,30,33)(H,31,34)/t14-,20-,22-/m0/s1
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n/an/a 47n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR2


(Artificial Sequence)
BDBM242863
PNG
(US9422332, 38)
Show SMILES CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F)C(C)(C)C
Show InChI InChI=1S/C26H32F2N4O3/c1-15(29-5)23(33)31-22(26(2,3)4)25(35)32-14-13-16-9-6-7-10-17(16)21(32)24(34)30-20-18(27)11-8-12-19(20)28/h6-12,15,21-22,29H,13-14H2,1-5H3,(H,30,34)(H,31,33)/t15-,21-,22+/m0/s1
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n/an/a 62n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR2


(Artificial Sequence)
BDBM242864
PNG
(US9422332, 39)
Show SMILES CN[C@@H](C)C(=O)N[C@@H]([C@@H](C)OC)C(=O)N1CCc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C25H30F2N4O4/c1-14(28-3)23(32)29-20(15(2)35-4)25(34)31-13-12-16-8-5-6-9-17(16)22(31)24(33)30-21-18(26)10-7-11-19(21)27/h5-11,14-15,20,22,28H,12-13H2,1-4H3,(H,29,32)(H,30,33)/t14-,15+,20-,22-/m0/s1
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n/an/a 93n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR2


(Artificial Sequence)
BDBM242841
PNG
(US9422332, 27)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1cccc2CCCCc12
Show InChI InChI=1S/C28H36N4O3/c1-17(2)24(31-26(33)18(3)29-4)28(35)32-16-20-11-6-8-14-22(20)25(32)27(34)30-23-15-9-12-19-10-5-7-13-21(19)23/h6,8-9,11-12,14-15,17-18,24-25,29H,5,7,10,13,16H2,1-4H3,(H,30,34)(H,31,33)/t18-,24-,25-/m0/s1
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n/an/a 106n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR2


(Artificial Sequence)
BDBM242838
PNG
(US9422332, 23)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1ccc2ccccc2c1
Show InChI InChI=1S/C28H32N4O3/c1-17(2)24(31-26(33)18(3)29-4)28(35)32-16-21-11-7-8-12-23(21)25(32)27(34)30-22-14-13-19-9-5-6-10-20(19)15-22/h5-15,17-18,24-25,29H,16H2,1-4H3,(H,30,34)(H,31,33)/t18-,24-,25-/m0/s1
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n/an/a 117n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR2


(Artificial Sequence)
BDBM242858
PNG
(US9422332, 40)
Show SMILES CN[C@@H](C)C(=O)N[C@@H]([C@@H](C)c1ccccc1)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C29H30F2N4O3/c1-17(19-10-5-4-6-11-19)24(33-27(36)18(2)32-3)29(38)35-16-20-12-7-8-13-21(20)26(35)28(37)34-25-22(30)14-9-15-23(25)31/h4-15,17-18,24,26,32H,16H2,1-3H3,(H,33,36)(H,34,37)/t17-,18-,24-,26-/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR2


(Artificial Sequence)
BDBM242835
PNG
(US9422332, 18)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2[C@@H]1C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C24H28F2N4O3/c1-13(2)19(28-22(31)14(3)27-4)24(33)30-12-15-8-5-6-9-16(15)21(30)23(32)29-20-17(25)10-7-11-18(20)26/h5-11,13-14,19,21,27H,12H2,1-4H3,(H,28,31)(H,29,32)/t14-,19-,21+/m0/s1
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n/an/a 139n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR2


(Artificial Sequence)
BDBM242846
PNG
(US9422332, 17)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2C1C(=O)Nc1ccccc1OC
Show InChI InChI=1S/C25H32N4O4/c1-15(2)21(28-23(30)16(3)26-4)25(32)29-14-17-10-6-7-11-18(17)22(29)24(31)27-19-12-8-9-13-20(19)33-5/h6-13,15-16,21-22,26H,14H2,1-5H3,(H,27,31)(H,28,30)/t16-,21-,22?/m0/s1
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n/an/a 177n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR2


(Artificial Sequence)
BDBM242847
PNG
(US9422332, 19)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2C1C(=O)NCc1ccccc1
Show InChI InChI=1S/C25H32N4O3/c1-16(2)21(28-23(30)17(3)26-4)25(32)29-15-19-12-8-9-13-20(19)22(29)24(31)27-14-18-10-6-5-7-11-18/h5-13,16-17,21-22,26H,14-15H2,1-4H3,(H,27,31)(H,28,30)/t17-,21-,22?/m0/s1
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n/an/a 210n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR2


(Artificial Sequence)
BDBM242845
PNG
(US9422332, 16)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2C1C(=O)Nc1ccccc1
Show InChI InChI=1S/C24H30N4O3/c1-15(2)20(27-22(29)16(3)25-4)24(31)28-14-17-10-8-9-13-19(17)21(28)23(30)26-18-11-6-5-7-12-18/h5-13,15-16,20-21,25H,14H2,1-4H3,(H,26,30)(H,27,29)/t16-,20-,21?/m0/s1
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n/an/a 233n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR2


(Artificial Sequence)
BDBM242849
PNG
(US9422332, 29)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2C1C(=O)Nc1nccc2ccccc12
Show InChI InChI=1S/C27H31N5O3/c1-16(2)22(30-25(33)17(3)28-4)27(35)32-15-19-10-6-7-11-20(19)23(32)26(34)31-24-21-12-8-5-9-18(21)13-14-29-24/h5-14,16-17,22-23,28H,15H2,1-4H3,(H,30,33)(H,29,31,34)/t17-,22-,23?/m0/s1
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n/an/a 345n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR3


(Artificial Sequence)
BDBM242847
PNG
(US9422332, 19)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2C1C(=O)NCc1ccccc1
Show InChI InChI=1S/C25H32N4O3/c1-16(2)21(28-23(30)17(3)26-4)25(32)29-15-19-12-8-9-13-20(19)22(29)24(31)27-14-18-10-6-5-7-11-18/h5-13,16-17,21-22,26H,14-15H2,1-4H3,(H,27,31)(H,28,30)/t17-,21-,22?/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR2


(Artificial Sequence)
BDBM242848
PNG
(US9422332, 20)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2C1C(=O)NCCc1ccccc1
Show InChI InChI=1S/C26H34N4O3/c1-17(2)22(29-24(31)18(3)27-4)26(33)30-16-20-12-8-9-13-21(20)23(30)25(32)28-15-14-19-10-6-5-7-11-19/h5-13,17-18,22-23,27H,14-16H2,1-4H3,(H,28,32)(H,29,31)/t18-,22-,23?/m0/s1
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n/an/a 810n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR3


(Artificial Sequence)
BDBM242848
PNG
(US9422332, 20)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2C1C(=O)NCCc1ccccc1
Show InChI InChI=1S/C26H34N4O3/c1-17(2)22(29-24(31)18(3)27-4)26(33)30-16-20-12-8-9-13-21(20)23(30)25(32)28-15-14-19-10-6-5-7-11-19/h5-13,17-18,22-23,27H,14-16H2,1-4H3,(H,28,32)(H,29,31)/t18-,22-,23?/m0/s1
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n/an/a 1.91E+3n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR2


(Artificial Sequence)
BDBM242869
PNG
(US9422332, 41)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1CCc2ccc(F)cc2[C@@H]1C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C25H29F3N4O3/c1-13(2)20(30-23(33)14(3)29-4)25(35)32-11-10-15-8-9-16(26)12-17(15)22(32)24(34)31-21-18(27)6-5-7-19(21)28/h5-9,12-14,20,22,29H,10-11H2,1-4H3,(H,30,33)(H,31,34)/t14-,20-,22+/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR3


(Artificial Sequence)
BDBM242836
PNG
(US9422332, 21)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1cccc2ccccc12
Show InChI InChI=1S/C28H32N4O3/c1-17(2)24(31-26(33)18(3)29-4)28(35)32-16-20-11-6-8-14-22(20)25(32)27(34)30-23-15-9-12-19-10-5-7-13-21(19)23/h5-15,17-18,24-25,29H,16H2,1-4H3,(H,30,34)(H,31,33)/t18-,24-,25-/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR2


(Artificial Sequence)
BDBM242837
PNG
(US9422332, 22)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2[C@@H]1C(=O)Nc1cccc2ccccc12
Show InChI InChI=1S/C28H32N4O3/c1-17(2)24(31-26(33)18(3)29-4)28(35)32-16-20-11-6-8-14-22(20)25(32)27(34)30-23-15-9-12-19-10-5-7-13-21(19)23/h5-15,17-18,24-25,29H,16H2,1-4H3,(H,30,34)(H,31,33)/t18-,24-,25+/m0/s1
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n/an/a 2.79E+3n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR3


(Artificial Sequence)
BDBM242846
PNG
(US9422332, 17)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2C1C(=O)Nc1ccccc1OC
Show InChI InChI=1S/C25H32N4O4/c1-15(2)21(28-23(30)16(3)26-4)25(32)29-14-17-10-6-7-11-18(17)22(29)24(31)27-19-12-8-9-13-20(19)33-5/h6-13,15-16,21-22,26H,14H2,1-5H3,(H,27,31)(H,28,30)/t16-,21-,22?/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR2


(Artificial Sequence)
BDBM242871
PNG
(US9422332, 43)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1CCc2cc(F)ccc2[C@@H]1C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C25H29F3N4O3/c1-13(2)20(30-23(33)14(3)29-4)25(35)32-11-10-15-12-16(26)8-9-17(15)22(32)24(34)31-21-18(27)6-5-7-19(21)28/h5-9,12-14,20,22,29H,10-11H2,1-4H3,(H,30,33)(H,31,34)/t14-,20-,22+/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR2


(Artificial Sequence)
BDBM242868
PNG
(US9422332, 46)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1CCc2cc(Cl)ccc2[C@@H]1C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C25H29ClF2N4O3/c1-13(2)20(30-23(33)14(3)29-4)25(35)32-11-10-15-12-16(26)8-9-17(15)22(32)24(34)31-21-18(27)6-5-7-19(21)28/h5-9,12-14,20,22,29H,10-11H2,1-4H3,(H,30,33)(H,31,34)/t14-,20-,22+/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR3


(Artificial Sequence)
BDBM242833
PNG
(US9422332, 8)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1Cl
Show InChI InChI=1S/C24H28ClFN4O3/c1-13(2)19(28-22(31)14(3)27-4)24(33)30-12-15-8-5-6-9-16(15)21(30)23(32)29-20-17(25)10-7-11-18(20)26/h5-11,13-14,19,21,27H,12H2,1-4H3,(H,28,31)(H,29,32)/t14-,19-,21-/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR2


(Artificial Sequence)
BDBM242866
PNG
(US9422332, 44)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1CCc2ccc(Cl)cc2[C@@H]1C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C25H29ClF2N4O3/c1-13(2)20(30-23(33)14(3)29-4)25(35)32-11-10-15-8-9-16(26)12-17(15)22(32)24(34)31-21-18(27)6-5-7-19(21)28/h5-9,12-14,20,22,29H,10-11H2,1-4H3,(H,30,33)(H,31,34)/t14-,20-,22+/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR3


(Artificial Sequence)
BDBM242840
PNG
(US9422332, 26)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1ccccc1Cl
Show InChI InChI=1S/C24H29ClN4O3/c1-14(2)20(28-22(30)15(3)26-4)24(32)29-13-16-9-5-6-10-17(16)21(29)23(31)27-19-12-8-7-11-18(19)25/h5-12,14-15,20-21,26H,13H2,1-4H3,(H,27,31)(H,28,30)/t15-,20-,21-/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR2


(Artificial Sequence)
BDBM242842
PNG
(US9422332, 28)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1cccc2cccnc12
Show InChI InChI=1S/C27H31N5O3/c1-16(2)22(31-25(33)17(3)28-4)27(35)32-15-19-9-5-6-12-20(19)24(32)26(34)30-21-13-7-10-18-11-8-14-29-23(18)21/h5-14,16-17,22,24,28H,15H2,1-4H3,(H,30,34)(H,31,33)/t17-,22-,24-/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR3


(Artificial Sequence)
BDBM242832
PNG
(US9422332, 7)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1c(Cl)cccc1Cl
Show InChI InChI=1S/C24H28Cl2N4O3/c1-13(2)19(28-22(31)14(3)27-4)24(33)30-12-15-8-5-6-9-16(15)21(30)23(32)29-20-17(25)10-7-11-18(20)26/h5-11,13-14,19,21,27H,12H2,1-4H3,(H,28,31)(H,29,32)/t14-,19-,21-/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR3


(Artificial Sequence)
BDBM242843
PNG
(US9422332, 30)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1cccc2n(C)ccc12
Show InChI InChI=1S/C27H33N5O3/c1-16(2)23(30-25(33)17(3)28-4)27(35)32-15-18-9-6-7-10-19(18)24(32)26(34)29-21-11-8-12-22-20(21)13-14-31(22)5/h6-14,16-17,23-24,28H,15H2,1-5H3,(H,29,34)(H,30,33)/t17-,23-,24-/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR3


(Artificial Sequence)
BDBM242829
PNG
(US9422332, 4)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1CCc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1Cl
Show InChI InChI=1S/C25H30ClFN4O3/c1-14(2)20(29-23(32)15(3)28-4)25(34)31-13-12-16-8-5-6-9-17(16)22(31)24(33)30-21-18(26)10-7-11-19(21)27/h5-11,14-15,20,22,28H,12-13H2,1-4H3,(H,29,32)(H,30,33)/t15-,20-,22-/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR3


(Artificial Sequence)
BDBM242872
PNG
(US9422332, 31)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2C[C@H]1C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C25H30F2N4O3/c1-14(2)21(29-23(32)15(3)28-4)25(34)31-13-17-9-6-5-8-16(17)12-20(31)24(33)30-22-18(26)10-7-11-19(22)27/h5-11,14-15,20-21,28H,12-13H2,1-4H3,(H,29,32)(H,30,33)/t15-,20-,21-/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR3


(Artificial Sequence)
BDBM242827
PNG
(US9422332, 2)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C1CCCCC1)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C27H32F2N4O3/c1-16(30-2)25(34)31-22(17-9-4-3-5-10-17)27(36)33-15-18-11-6-7-12-19(18)24(33)26(35)32-23-20(28)13-8-14-21(23)29/h6-8,11-14,16-17,22,24,30H,3-5,9-10,15H2,1-2H3,(H,31,34)(H,32,35)/t16-,22-,24-/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR3


(Artificial Sequence)
BDBM242834
PNG
(US9422332, 9)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1cccc2sccc12
Show InChI InChI=1S/C26H30N4O3S/c1-15(2)22(29-24(31)16(3)27-4)26(33)30-14-17-8-5-6-9-18(17)23(30)25(32)28-20-10-7-11-21-19(20)12-13-34-21/h5-13,15-16,22-23,27H,14H2,1-4H3,(H,28,32)(H,29,31)/t16-,22-,23-/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR3


(Artificial Sequence)
BDBM242841
PNG
(US9422332, 27)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1cccc2CCCCc12
Show InChI InChI=1S/C28H36N4O3/c1-17(2)24(31-26(33)18(3)29-4)28(35)32-16-20-11-6-8-14-22(20)25(32)27(34)30-23-15-9-12-19-10-5-7-13-21(19)23/h6,8-9,11-12,14-15,17-18,24-25,29H,5,7,10,13,16H2,1-4H3,(H,30,34)(H,31,33)/t18-,24-,25-/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR3


(Artificial Sequence)
BDBM242850
PNG
(US9422332, 10)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C25H30F2N4O3/c1-5-14(2)20(29-23(32)15(3)28-4)25(34)31-13-16-9-6-7-10-17(16)22(31)24(33)30-21-18(26)11-8-12-19(21)27/h6-12,14-15,20,22,28H,5,13H2,1-4H3,(H,29,32)(H,30,33)/t14-,15-,20-,22-/m0/s1
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n/an/a 1.52E+4n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR3


(Artificial Sequence)
BDBM242849
PNG
(US9422332, 29)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2C1C(=O)Nc1nccc2ccccc12
Show InChI InChI=1S/C27H31N5O3/c1-16(2)22(30-25(33)17(3)28-4)27(35)32-15-19-10-6-7-11-20(19)23(32)26(34)31-24-21-12-8-5-9-18(21)13-14-29-24/h5-14,16-17,22-23,28H,15H2,1-4H3,(H,30,33)(H,29,31,34)/t17-,22-,23?/m0/s1
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n/an/a 1.60E+4n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR3


(Artificial Sequence)
BDBM242839
PNG
(US9422332, 24)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1ccccc1F
Show InChI InChI=1S/C24H29FN4O3/c1-14(2)20(28-22(30)15(3)26-4)24(32)29-13-16-9-5-6-10-17(16)21(29)23(31)27-19-12-8-7-11-18(19)25/h5-12,14-15,20-21,26H,13H2,1-4H3,(H,27,31)(H,28,30)/t15-,20-,21-/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR3


(Artificial Sequence)
BDBM242838
PNG
(US9422332, 23)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1ccc2ccccc2c1
Show InChI InChI=1S/C28H32N4O3/c1-17(2)24(31-26(33)18(3)29-4)28(35)32-16-21-11-7-8-12-23(21)25(32)27(34)30-22-14-13-19-9-5-6-10-20(19)15-22/h5-15,17-18,24-25,29H,16H2,1-4H3,(H,30,34)(H,31,33)/t18-,24-,25-/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR3


(Artificial Sequence)
BDBM242853
PNG
(US9422332, 13)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C1CCCC1)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C26H30F2N4O3/c1-15(29-2)24(33)30-21(16-8-3-4-9-16)26(35)32-14-17-10-5-6-11-18(17)23(32)25(34)31-22-19(27)12-7-13-20(22)28/h5-7,10-13,15-16,21,23,29H,3-4,8-9,14H2,1-2H3,(H,30,33)(H,31,34)/t15-,21-,23-/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR3


(Artificial Sequence)
BDBM242826
PNG
(US9422332, 1)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C24H28F2N4O3/c1-13(2)19(28-22(31)14(3)27-4)24(33)30-12-15-8-5-6-9-16(15)21(30)23(32)29-20-17(25)10-7-11-18(20)26/h5-11,13-14,19,21,27H,12H2,1-4H3,(H,28,31)(H,29,32)/t14-,19-,21-/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR3


(Artificial Sequence)
BDBM242842
PNG
(US9422332, 28)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1cccc2cccnc12
Show InChI InChI=1S/C27H31N5O3/c1-16(2)22(31-25(33)17(3)28-4)27(35)32-15-19-9-5-6-12-20(19)24(32)26(34)30-21-13-7-10-18-11-8-14-29-23(18)21/h5-14,16-17,22,24,28H,15H2,1-4H3,(H,30,34)(H,31,33)/t17-,22-,24-/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR3


(Artificial Sequence)
BDBM242857
PNG
(US9422332, 35)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C25H30F2N4O3/c1-14(2)12-20(29-23(32)15(3)28-4)25(34)31-13-16-8-5-6-9-17(16)22(31)24(33)30-21-18(26)10-7-11-19(21)27/h5-11,14-15,20,22,28H,12-13H2,1-4H3,(H,29,32)(H,30,33)/t15-,20-,22-/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR3


(Artificial Sequence)
BDBM242830
PNG
(US9422332, 5)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1CCc2cc(Cl)ccc2[C@H]1C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C25H29ClF2N4O3/c1-13(2)20(30-23(33)14(3)29-4)25(35)32-11-10-15-12-16(26)8-9-17(15)22(32)24(34)31-21-18(27)6-5-7-19(21)28/h5-9,12-14,20,22,29H,10-11H2,1-4H3,(H,30,33)(H,31,34)/t14-,20-,22-/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR3


(Artificial Sequence)
BDBM242859
PNG
(US9422332, 14)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C1CCOCC1)C(=O)N1CCc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C27H32F2N4O4/c1-16(30-2)25(34)31-22(18-11-14-37-15-12-18)27(36)33-13-10-17-6-3-4-7-19(17)24(33)26(35)32-23-20(28)8-5-9-21(23)29/h3-9,16,18,22,24,30H,10-15H2,1-2H3,(H,31,34)(H,32,35)/t16-,22-,24-/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR3


(Artificial Sequence)
BDBM242828
PNG
(US9422332, 3)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C1CCCCC1)C(=O)N1CCc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C28H34F2N4O3/c1-17(31-2)26(35)32-23(19-10-4-3-5-11-19)28(37)34-16-15-18-9-6-7-12-20(18)25(34)27(36)33-24-21(29)13-8-14-22(24)30/h6-9,12-14,17,19,23,25,31H,3-5,10-11,15-16H2,1-2H3,(H,32,35)(H,33,36)/t17-,23-,25-/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR3


(Artificial Sequence)
BDBM242854
PNG
(US9422332, 32)
Show SMILES CN[C@@H](C)C(=O)N[C@@H]([C@@H](C)OC)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C24H28F2N4O4/c1-13(27-3)22(31)28-19(14(2)34-4)24(33)30-12-15-8-5-6-9-16(15)21(30)23(32)29-20-17(25)10-7-11-18(20)26/h5-11,13-14,19,21,27H,12H2,1-4H3,(H,28,31)(H,29,32)/t13-,14+,19-,21-/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR3


(Artificial Sequence)
BDBM242855
PNG
(US9422332, 33)
Show SMILES CN[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C23H26F2N4O4/c1-12(26-3)21(31)27-18(13(2)30)23(33)29-11-14-7-4-5-8-15(14)20(29)22(32)28-19-16(24)9-6-10-17(19)25/h4-10,12-13,18,20,26,30H,11H2,1-3H3,(H,27,31)(H,28,32)/t12-,13+,18-,20-/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR3


(Artificial Sequence)
BDBM242871
PNG
(US9422332, 43)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1CCc2cc(F)ccc2[C@@H]1C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C25H29F3N4O3/c1-13(2)20(30-23(33)14(3)29-4)25(35)32-11-10-15-12-16(26)8-9-17(15)22(32)24(34)31-21-18(27)6-5-7-19(21)28/h5-9,12-14,20,22,29H,10-11H2,1-4H3,(H,30,33)(H,31,34)/t14-,20-,22+/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR3


(Artificial Sequence)
BDBM242864
PNG
(US9422332, 39)
Show SMILES CN[C@@H](C)C(=O)N[C@@H]([C@@H](C)OC)C(=O)N1CCc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C25H30F2N4O4/c1-14(28-3)23(32)29-20(15(2)35-4)25(34)31-13-12-16-8-5-6-9-17(16)22(31)24(33)30-21-18(26)10-7-11-19(21)27/h5-11,14-15,20,22,28H,12-13H2,1-4H3,(H,29,32)(H,30,33)/t14-,15+,20-,22-/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR3


(Artificial Sequence)
BDBM242861
PNG
(US9422332, 25)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1CCc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C25H30F2N4O3/c1-14(2)20(29-23(32)15(3)28-4)25(34)31-13-12-16-8-5-6-9-17(16)22(31)24(33)30-21-18(26)10-7-11-19(21)27/h5-11,14-15,20,22,28H,12-13H2,1-4H3,(H,29,32)(H,30,33)/t15-,20-,22-/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR3


(Artificial Sequence)
BDBM242844
PNG
(US9422332, 47)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1c(C)cccc1F
Show InChI InChI=1S/C25H31FN4O3/c1-14(2)20(28-23(31)16(4)27-5)25(33)30-13-17-10-6-7-11-18(17)22(30)24(32)29-21-15(3)9-8-12-19(21)26/h6-12,14,16,20,22,27H,13H2,1-5H3,(H,28,31)(H,29,32)/t16-,20-,22-/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR3


(Artificial Sequence)
BDBM242835
PNG
(US9422332, 18)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2[C@@H]1C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C24H28F2N4O3/c1-13(2)19(28-22(31)14(3)27-4)24(33)30-12-15-8-5-6-9-16(15)21(30)23(32)29-20-17(25)10-7-11-18(20)26/h5-11,13-14,19,21,27H,12H2,1-4H3,(H,28,31)(H,29,32)/t14-,19-,21+/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR3


(Artificial Sequence)
BDBM242837
PNG
(US9422332, 22)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2[C@@H]1C(=O)Nc1cccc2ccccc12
Show InChI InChI=1S/C28H32N4O3/c1-17(2)24(31-26(33)18(3)29-4)28(35)32-16-20-11-6-8-14-22(20)25(32)27(34)30-23-15-9-12-19-10-5-7-13-21(19)23/h5-15,17-18,24-25,29H,16H2,1-4H3,(H,30,34)(H,31,33)/t18-,24-,25+/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR3


(Artificial Sequence)
BDBM242867
PNG
(US9422332, 45)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1CCc2ccc(Cl)cc2[C@H]1C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C25H29ClF2N4O3/c1-13(2)20(30-23(33)14(3)29-4)25(35)32-11-10-15-8-9-16(26)12-17(15)22(32)24(34)31-21-18(27)6-5-7-19(21)28/h5-9,12-14,20,22,29H,10-11H2,1-4H3,(H,30,33)(H,31,34)/t14-,20-,22-/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR3


(Artificial Sequence)
BDBM242860
PNG
(US9422332, 15)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC)C(=O)N1CCc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C26H32F2N4O3/c1-5-15(2)21(30-24(33)16(3)29-4)26(35)32-14-13-17-9-6-7-10-18(17)23(32)25(34)31-22-19(27)11-8-12-20(22)28/h6-12,15-16,21,23,29H,5,13-14H2,1-4H3,(H,30,33)(H,31,34)/t15-,16-,21-,23-/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR3


(Artificial Sequence)
BDBM242868
PNG
(US9422332, 46)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1CCc2cc(Cl)ccc2[C@@H]1C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C25H29ClF2N4O3/c1-13(2)20(30-23(33)14(3)29-4)25(35)32-11-10-15-12-16(26)8-9-17(15)22(32)24(34)31-21-18(27)6-5-7-19(21)28/h5-9,12-14,20,22,29H,10-11H2,1-4H3,(H,30,33)(H,31,34)/t14-,20-,22+/m0/s1
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n/an/a>5.48E+4n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR3


(Artificial Sequence)
BDBM242866
PNG
(US9422332, 44)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1CCc2ccc(Cl)cc2[C@@H]1C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C25H29ClF2N4O3/c1-13(2)20(30-23(33)14(3)29-4)25(35)32-11-10-15-8-9-16(26)12-17(15)22(32)24(34)31-21-18(27)6-5-7-19(21)28/h5-9,12-14,20,22,29H,10-11H2,1-4H3,(H,30,33)(H,31,34)/t14-,20-,22+/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR3


(Artificial Sequence)
BDBM242851
PNG
(US9422332, 11)
Show SMILES CN[C@@H](C)C(=O)N[C@H](C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F)C(C)(C)C
Show InChI InChI=1S/C25H30F2N4O3/c1-14(28-5)22(32)30-21(25(2,3)4)24(34)31-13-15-9-6-7-10-16(15)20(31)23(33)29-19-17(26)11-8-12-18(19)27/h6-12,14,20-21,28H,13H2,1-5H3,(H,29,33)(H,30,32)/t14-,20-,21+/m0/s1
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n/an/a>5.48E+4n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR3


(Artificial Sequence)
BDBM242858
PNG
(US9422332, 40)
Show SMILES CN[C@@H](C)C(=O)N[C@@H]([C@@H](C)c1ccccc1)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C29H30F2N4O3/c1-17(19-10-5-4-6-11-19)24(33-27(36)18(2)32-3)29(38)35-16-20-12-7-8-13-21(20)26(35)28(37)34-25-22(30)14-9-15-23(25)31/h4-15,17-18,24,26,32H,16H2,1-3H3,(H,33,36)(H,34,37)/t17-,18-,24-,26-/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR3


(Artificial Sequence)
BDBM242845
PNG
(US9422332, 16)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2C1C(=O)Nc1ccccc1
Show InChI InChI=1S/C24H30N4O3/c1-15(2)20(27-22(29)16(3)25-4)24(31)28-14-17-10-8-9-13-19(17)21(28)23(30)26-18-11-6-5-7-12-18/h5-13,15-16,20-21,25H,14H2,1-4H3,(H,26,30)(H,27,29)/t16-,20-,21?/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR3


(Artificial Sequence)
BDBM242863
PNG
(US9422332, 38)
Show SMILES CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F)C(C)(C)C
Show InChI InChI=1S/C26H32F2N4O3/c1-15(29-5)23(33)31-22(26(2,3)4)25(35)32-14-13-16-9-6-7-10-17(16)21(32)24(34)30-20-18(27)11-8-12-19(20)28/h6-12,15,21-22,29H,13-14H2,1-5H3,(H,30,34)(H,31,33)/t15-,21-,22+/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR3


(Artificial Sequence)
BDBM242870
PNG
(US9422332, 42)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1CCc2ccc(F)cc2[C@H]1C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C25H29F3N4O3/c1-13(2)20(30-23(33)14(3)29-4)25(35)32-11-10-15-8-9-16(26)12-17(15)22(32)24(34)31-21-18(27)6-5-7-19(21)28/h5-9,12-14,20,22,29H,10-11H2,1-4H3,(H,30,33)(H,31,34)/t14-,20-,22-/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR3


(Artificial Sequence)
BDBM242831
PNG
(US9422332, 6)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1CCc2cc(F)ccc2[C@H]1C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C25H29F3N4O3/c1-13(2)20(30-23(33)14(3)29-4)25(35)32-11-10-15-12-16(26)8-9-17(15)22(32)24(34)31-21-18(27)6-5-7-19(21)28/h5-9,12-14,20,22,29H,10-11H2,1-4H3,(H,30,33)(H,31,34)/t14-,20-,22-/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR3


(Artificial Sequence)
BDBM242865
PNG
(US9422332, 36)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1CCc2ccccc2[C@H]1C(=O)Nc1c(Cl)cccc1Cl
Show InChI InChI=1S/C25H30Cl2N4O3/c1-14(2)20(29-23(32)15(3)28-4)25(34)31-13-12-16-8-5-6-9-17(16)22(31)24(33)30-21-18(26)10-7-11-19(21)27/h5-11,14-15,20,22,28H,12-13H2,1-4H3,(H,29,32)(H,30,33)/t15-,20-,22-/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR3


(Artificial Sequence)
BDBM242862
PNG
(US9422332, 37)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C1CCCC1)C(=O)N1CCc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C27H32F2N4O3/c1-16(30-2)25(34)31-22(18-9-3-4-10-18)27(36)33-15-14-17-8-5-6-11-19(17)24(33)26(35)32-23-20(28)12-7-13-21(23)29/h5-8,11-13,16,18,22,24,30H,3-4,9-10,14-15H2,1-2H3,(H,31,34)(H,32,35)/t16-,22-,24-/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
XIAP protein BIR3


(Artificial Sequence)
BDBM242869
PNG
(US9422332, 41)
Show SMILES CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1CCc2ccc(F)cc2[C@@H]1C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C25H29F3N4O3/c1-13(2)20(30-23(33)14(3)29-4)25(35)32-11-10-15-8-9-16(26)12-17(15)22(32)24(34)31-21-18(27)6-5-7-19(21)28/h5-9,12-14,20,22,29H,10-11H2,1-4H3,(H,30,33)(H,31,34)/t14-,20-,22+/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
The peptide AVPIAQKSEK-(ε-biotin)-OH 1:2 TFA ("Peptide A") was identified as a substrate for the TR-FRET assay by screening the 6× Hist...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%