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Patent code US9428500

Compile Data Set for Download or QSAR
Found 117 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245258
PNG
(US9428500, 52)
Show SMILES COc1cc(c(OC)cc1Cc1ccccc1)-c1ccnc2[nH]c3ccc(cc3c12)-c1ccc(cc1)N1CCN(C)CC1
Show InChI InChI=1S/C37H36N4O2/c1-40-17-19-41(20-18-40)29-12-9-26(10-13-29)27-11-14-33-32(22-27)36-30(15-16-38-37(36)39-33)31-24-34(42-2)28(23-35(31)43-3)21-25-7-5-4-6-8-25/h4-16,22-24H,17-21H2,1-3H3,(H,38,39)
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n/an/a 22n/an/an/an/an/an/a



UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245264
PNG
(US9428500, 58)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(N4CCC(Cc5ccccc5)CC4)c3c2c1
Show InChI InChI=1S/C34H37N5/c1-37-19-21-38(22-20-37)29-10-7-27(8-11-29)28-9-12-31-30(24-28)33-32(13-16-35-34(33)36-31)39-17-14-26(15-18-39)23-25-5-3-2-4-6-25/h2-13,16,24,26H,14-15,17-23H2,1H3,(H,35,36)
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n/an/a 32n/an/an/an/an/an/a



UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245222
PNG
(US9428500, 16)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(-c4ccc(Cc5ccccc5)cc4)c3c2c1
Show InChI InChI=1S/C35H32N4/c1-38-19-21-39(22-20-38)30-14-11-27(12-15-30)29-13-16-33-32(24-29)34-31(17-18-36-35(34)37-33)28-9-7-26(8-10-28)23-25-5-3-2-4-6-25/h2-18,24H,19-23H2,1H3,(H,36,37)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245230
PNG
(US9428500, 24)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(-c4ccc(cc4)-c4cccc5ccccc45)c3c2c1
Show InChI InChI=1S/C38H32N4/c1-41-21-23-42(24-22-41)31-16-13-26(14-17-31)30-15-18-36-35(25-30)37-34(19-20-39-38(37)40-36)29-11-9-28(10-12-29)33-8-4-6-27-5-2-3-7-32(27)33/h2-20,25H,21-24H2,1H3,(H,39,40)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245218
PNG
(US9428500, 12)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(-c4ccc(COc5ccc(Cl)c(C)c5)cc4)c3c2c1
Show InChI InChI=1S/C36H33ClN4O/c1-24-21-30(12-13-33(24)37)42-23-25-3-5-27(6-4-25)31-15-16-38-36-35(31)32-22-28(9-14-34(32)39-36)26-7-10-29(11-8-26)41-19-17-40(2)18-20-41/h3-16,21-22H,17-20,23H2,1-2H3,(H,38,39)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245230
PNG
(US9428500, 24)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(-c4ccc(cc4)-c4cccc5ccccc45)c3c2c1
Show InChI InChI=1S/C38H32N4/c1-41-21-23-42(24-22-41)31-16-13-26(14-17-31)30-15-18-36-35(25-30)37-34(19-20-39-38(37)40-36)29-11-9-28(10-12-29)33-8-4-6-27-5-2-3-7-32(27)33/h2-20,25H,21-24H2,1H3,(H,39,40)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245219
PNG
(US9428500, 13)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(\C=C\c4ccc(F)cc4)c3c2c1
Show InChI InChI=1S/C30H27FN4/c1-34-16-18-35(19-17-34)26-11-6-22(7-12-26)24-8-13-28-27(20-24)29-23(14-15-32-30(29)33-28)5-2-21-3-9-25(31)10-4-21/h2-15,20H,16-19H2,1H3,(H,32,33)/b5-2+
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245216
PNG
(US9428500, 10)
Show SMILES COc1ccccc1\C=C\c1ccnc2[nH]c3ccc(cc3c12)-c1ccc(cc1)N1CCN(C)CC1
Show InChI InChI=1S/C31H30N4O/c1-34-17-19-35(20-18-34)26-12-9-22(10-13-26)25-11-14-28-27(21-25)30-24(15-16-32-31(30)33-28)8-7-23-5-3-4-6-29(23)36-2/h3-16,21H,17-20H2,1-2H3,(H,32,33)/b8-7+
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245218
PNG
(US9428500, 12)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(-c4ccc(COc5ccc(Cl)c(C)c5)cc4)c3c2c1
Show InChI InChI=1S/C36H33ClN4O/c1-24-21-30(12-13-33(24)37)42-23-25-3-5-27(6-4-25)31-15-16-38-36-35(31)32-22-28(9-14-34(32)39-36)26-7-10-29(11-8-26)41-19-17-40(2)18-20-41/h3-16,21-22H,17-20,23H2,1-2H3,(H,38,39)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245220
PNG
(US9428500, 14)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(\C=C\c4ccc(cc4)C(F)(F)F)c3c2c1
Show InChI InChI=1S/C31H27F3N4/c1-37-16-18-38(19-17-37)26-11-6-22(7-12-26)24-8-13-28-27(20-24)29-23(14-15-35-30(29)36-28)5-2-21-3-9-25(10-4-21)31(32,33)34/h2-15,20H,16-19H2,1H3,(H,35,36)/b5-2+
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245246
PNG
(US9428500, 40)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(C#Cc4ccc(F)cc4)c3c2c1
Show InChI InChI=1S/C30H25FN4/c1-34-16-18-35(19-17-34)26-11-6-22(7-12-26)24-8-13-28-27(20-24)29-23(14-15-32-30(29)33-28)5-2-21-3-9-25(31)10-4-21/h3-4,6-15,20H,16-19H2,1H3,(H,32,33)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245243
PNG
(US9428500, 37)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(C#Cc4ccccc4)c3c2c1
Show InChI InChI=1S/C30H26N4/c1-33-17-19-34(20-18-33)26-12-9-23(10-13-26)25-11-14-28-27(21-25)29-24(15-16-31-30(29)32-28)8-7-22-5-3-2-4-6-22/h2-6,9-16,21H,17-20H2,1H3,(H,31,32)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245247
PNG
(US9428500, 41)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(C#Cc4ccccc4F)c3c2c1
Show InChI InChI=1S/C30H25FN4/c1-34-16-18-35(19-17-34)25-11-8-21(9-12-25)24-10-13-28-26(20-24)29-23(14-15-32-30(29)33-28)7-6-22-4-2-3-5-27(22)31/h2-5,8-15,20H,16-19H2,1H3,(H,32,33)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245223
PNG
(US9428500, 17)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(-c4cccc(c4)-c4ccccc4)c3c2c1
Show InChI InChI=1S/C34H30N4/c1-37-18-20-38(21-19-37)29-13-10-25(11-14-29)27-12-15-32-31(23-27)33-30(16-17-35-34(33)36-32)28-9-5-8-26(22-28)24-6-3-2-4-7-24/h2-17,22-23H,18-21H2,1H3,(H,35,36)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245229
PNG
(US9428500, 23)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(-c4ccc(cc4)C(=O)c4ccccc4)c3c2c1
Show InChI InChI=1S/C35H30N4O/c1-38-19-21-39(22-20-38)29-14-11-24(12-15-29)28-13-16-32-31(23-28)33-30(17-18-36-35(33)37-32)25-7-9-27(10-8-25)34(40)26-5-3-2-4-6-26/h2-18,23H,19-22H2,1H3,(H,36,37)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245224
PNG
(US9428500, 18)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(\C=C\c4ccccc4F)c3c2c1
Show InChI InChI=1S/C30H27FN4/c1-34-16-18-35(19-17-34)25-11-8-21(9-12-25)24-10-13-28-26(20-24)29-23(14-15-32-30(29)33-28)7-6-22-4-2-3-5-27(22)31/h2-15,20H,16-19H2,1H3,(H,32,33)/b7-6+
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245234
PNG
(US9428500, 28)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(\C(C)=C\c4ccccc4)c3c2c1
Show InChI InChI=1S/C31H30N4/c1-22(20-23-6-4-3-5-7-23)27-14-15-32-31-30(27)28-21-25(10-13-29(28)33-31)24-8-11-26(12-9-24)35-18-16-34(2)17-19-35/h3-15,20-21H,16-19H2,1-2H3,(H,32,33)/b22-20+
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245235
PNG
(US9428500, 29)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(\C=C\c4ccccc4NS(C)(=O)=O)c3c2c1
Show InChI InChI=1S/C31H31N5O2S/c1-35-17-19-36(20-18-35)26-12-9-22(10-13-26)25-11-14-29-27(21-25)30-24(15-16-32-31(30)33-29)8-7-23-5-3-4-6-28(23)34-39(2,37)38/h3-16,21,34H,17-20H2,1-2H3,(H,32,33)/b8-7+
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245217
PNG
(US9428500, 11)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(\C=C\c4ccccc4C(F)(F)F)c3c2c1
Show InChI InChI=1S/C31H27F3N4/c1-37-16-18-38(19-17-37)25-11-8-21(9-12-25)24-10-13-28-26(20-24)29-23(14-15-35-30(29)36-28)7-6-22-4-2-3-5-27(22)31(32,33)34/h2-15,20H,16-19H2,1H3,(H,35,36)/b7-6+
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245213
PNG
(US9428500, 7)
Show SMILES COc1ccc(\C=C\c2ccnc3[nH]c4ccc(cc4c23)-c2ccc(cc2)N2CCN(C)CC2)cc1
Show InChI InChI=1S/C31H30N4O/c1-34-17-19-35(20-18-34)26-10-7-23(8-11-26)25-9-14-29-28(21-25)30-24(15-16-32-31(30)33-29)6-3-22-4-12-27(36-2)13-5-22/h3-16,21H,17-20H2,1-2H3,(H,32,33)/b6-3+
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n/an/a 170n/an/an/an/an/an/a



UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245243
PNG
(US9428500, 37)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(C#Cc4ccccc4)c3c2c1
Show InChI InChI=1S/C30H26N4/c1-33-17-19-34(20-18-33)26-12-9-23(10-13-26)25-11-14-28-27(21-25)29-24(15-16-31-30(29)32-28)8-7-22-5-3-2-4-6-22/h2-6,9-16,21H,17-20H2,1H3,(H,31,32)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245240
PNG
(US9428500, 34 | US9428500, 35)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(Nc4ccccc4[N+]([O-])=O)c3c2c1
Show InChI InChI=1S/C28H26N6O2/c1-32-14-16-33(17-15-32)21-9-6-19(7-10-21)20-8-11-23-22(18-20)27-25(12-13-29-28(27)31-23)30-24-4-2-3-5-26(24)34(35)36/h2-13,18H,14-17H2,1H3,(H2,29,30,31)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245222
PNG
(US9428500, 16)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(-c4ccc(Cc5ccccc5)cc4)c3c2c1
Show InChI InChI=1S/C35H32N4/c1-38-19-21-39(22-20-38)30-14-11-27(12-15-30)29-13-16-33-32(24-29)34-31(17-18-36-35(34)37-33)28-9-7-26(8-10-28)23-25-5-3-2-4-6-25/h2-18,24H,19-23H2,1H3,(H,36,37)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245264
PNG
(US9428500, 58)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(N4CCC(Cc5ccccc5)CC4)c3c2c1
Show InChI InChI=1S/C34H37N5/c1-37-19-21-38(22-20-37)29-10-7-27(8-11-29)28-9-12-31-30(24-28)33-32(13-16-35-34(33)36-31)39-17-14-26(15-18-39)23-25-5-3-2-4-6-25/h2-13,16,24,26H,14-15,17-23H2,1H3,(H,35,36)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245223
PNG
(US9428500, 17)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(-c4cccc(c4)-c4ccccc4)c3c2c1
Show InChI InChI=1S/C34H30N4/c1-37-18-20-38(21-19-37)29-13-10-25(11-14-29)27-12-15-32-31(23-27)33-30(16-17-35-34(33)36-32)28-9-5-8-26(22-28)24-6-3-2-4-7-24/h2-17,22-23H,18-21H2,1H3,(H,35,36)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245239
PNG
(US9428500, 33)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(-c4ccc(cc4)C(O)c4ccccc4)c3c2c1
Show InChI InChI=1S/C35H32N4O/c1-38-19-21-39(22-20-38)29-14-11-24(12-15-29)28-13-16-32-31(23-28)33-30(17-18-36-35(33)37-32)25-7-9-27(10-8-25)34(40)26-5-3-2-4-6-26/h2-18,23,34,40H,19-22H2,1H3,(H,36,37)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245212
PNG
(US9428500, 6)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(\C=C\c4cccc(F)c4)c3c2c1
Show InChI InChI=1S/C30H27FN4/c1-34-15-17-35(18-16-34)26-10-7-22(8-11-26)24-9-12-28-27(20-24)29-23(13-14-32-30(29)33-28)6-5-21-3-2-4-25(31)19-21/h2-14,19-20H,15-18H2,1H3,(H,32,33)/b6-5+
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245217
PNG
(US9428500, 11)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(\C=C\c4ccccc4C(F)(F)F)c3c2c1
Show InChI InChI=1S/C31H27F3N4/c1-37-16-18-38(19-17-37)25-11-8-21(9-12-25)24-10-13-28-26(20-24)29-23(14-15-35-30(29)36-28)7-6-22-4-2-3-5-27(22)31(32,33)34/h2-15,20H,16-19H2,1H3,(H,35,36)/b7-6+
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245234
PNG
(US9428500, 28)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(\C(C)=C\c4ccccc4)c3c2c1
Show InChI InChI=1S/C31H30N4/c1-22(20-23-6-4-3-5-7-23)27-14-15-32-31-30(27)28-21-25(10-13-29(28)33-31)24-8-11-26(12-9-24)35-18-16-34(2)17-19-35/h3-15,20-21H,16-19H2,1-2H3,(H,32,33)/b22-20+
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245245
PNG
(US9428500, 39)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(C#Cc4ccccc4C(F)(F)F)c3c2c1
Show InChI InChI=1S/C31H25F3N4/c1-37-16-18-38(19-17-37)25-11-8-21(9-12-25)24-10-13-28-26(20-24)29-23(14-15-35-30(29)36-28)7-6-22-4-2-3-5-27(22)31(32,33)34/h2-5,8-15,20H,16-19H2,1H3,(H,35,36)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245220
PNG
(US9428500, 14)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(\C=C\c4ccc(cc4)C(F)(F)F)c3c2c1
Show InChI InChI=1S/C31H27F3N4/c1-37-16-18-38(19-17-37)26-11-6-22(7-12-26)24-8-13-28-27(20-24)29-23(14-15-35-30(29)36-28)5-2-21-3-9-25(10-4-21)31(32,33)34/h2-15,20H,16-19H2,1H3,(H,35,36)/b5-2+
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245235
PNG
(US9428500, 29)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(\C=C\c4ccccc4NS(C)(=O)=O)c3c2c1
Show InChI InChI=1S/C31H31N5O2S/c1-35-17-19-36(20-18-35)26-12-9-22(10-13-26)25-11-14-29-27(21-25)30-24(15-16-32-31(30)33-29)8-7-23-5-3-4-6-28(23)34-39(2,37)38/h3-16,21,34H,17-20H2,1-2H3,(H,32,33)/b8-7+
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245244
PNG
(US9428500, 38)
Show SMILES COc1ccccc1C#Cc1ccnc2[nH]c3ccc(cc3c12)-c1ccc(cc1)N1CCN(C)CC1
Show InChI InChI=1S/C31H28N4O/c1-34-17-19-35(20-18-34)26-12-9-22(10-13-26)25-11-14-28-27(21-25)30-24(15-16-32-31(30)33-28)8-7-23-5-3-4-6-29(23)36-2/h3-6,9-16,21H,17-20H2,1-2H3,(H,32,33)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245248
PNG
(US9428500, 42)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(C#Cc4ccccc4Cl)c3c2c1
Show InChI InChI=1S/C30H25ClN4/c1-34-16-18-35(19-17-34)25-11-8-21(9-12-25)24-10-13-28-26(20-24)29-23(14-15-32-30(29)33-28)7-6-22-4-2-3-5-27(22)31/h2-5,8-15,20H,16-19H2,1H3,(H,32,33)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245258
PNG
(US9428500, 52)
Show SMILES COc1cc(c(OC)cc1Cc1ccccc1)-c1ccnc2[nH]c3ccc(cc3c12)-c1ccc(cc1)N1CCN(C)CC1
Show InChI InChI=1S/C37H36N4O2/c1-40-17-19-41(20-18-40)29-12-9-26(10-13-29)27-11-14-33-32(22-27)36-30(15-16-38-37(36)39-33)31-24-34(42-2)28(23-35(31)43-3)21-25-7-5-4-6-8-25/h4-16,22-24H,17-21H2,1-3H3,(H,38,39)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245225
PNG
(US9428500, 19)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(\C=C\c4ccccc4Cl)c3c2c1
Show InChI InChI=1S/C30H27ClN4/c1-34-16-18-35(19-17-34)25-11-8-21(9-12-25)24-10-13-28-26(20-24)29-23(14-15-32-30(29)33-28)7-6-22-4-2-3-5-27(22)31/h2-15,20H,16-19H2,1H3,(H,32,33)/b7-6+
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245212
PNG
(US9428500, 6)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(\C=C\c4cccc(F)c4)c3c2c1
Show InChI InChI=1S/C30H27FN4/c1-34-15-17-35(18-16-34)26-10-7-22(8-11-26)24-9-12-28-27(20-24)29-23(13-14-32-30(29)33-28)6-5-21-3-2-4-25(31)19-21/h2-14,19-20H,15-18H2,1H3,(H,32,33)/b6-5+
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245216
PNG
(US9428500, 10)
Show SMILES COc1ccccc1\C=C\c1ccnc2[nH]c3ccc(cc3c12)-c1ccc(cc1)N1CCN(C)CC1
Show InChI InChI=1S/C31H30N4O/c1-34-17-19-35(20-18-34)26-12-9-22(10-13-26)25-11-14-28-27(21-25)30-24(15-16-32-31(30)33-28)8-7-23-5-3-4-6-29(23)36-2/h3-16,21H,17-20H2,1-2H3,(H,32,33)/b8-7+
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245210
PNG
(US9428500, 4)
Show SMILES CN1CCN(CC1)c1ccc(cn1)-c1ccc2[nH]c3nccc(\C=C\c4ccccc4)c3c2c1
Show InChI InChI=1S/C29H27N5/c1-33-15-17-34(18-16-33)27-12-10-24(20-31-27)23-9-11-26-25(19-23)28-22(13-14-30-29(28)32-26)8-7-21-5-3-2-4-6-21/h2-14,19-20H,15-18H2,1H3,(H,30,32)/b8-7+
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n/an/a 350n/an/an/an/an/an/a



UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245215
PNG
(US9428500, 9)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(-c4ccc(COc5cccc(c5)C(F)(F)F)cc4)c3c2c1
Show InChI InChI=1S/C36H31F3N4O/c1-42-17-19-43(20-18-42)29-12-9-25(10-13-29)27-11-14-33-32(21-27)34-31(15-16-40-35(34)41-33)26-7-5-24(6-8-26)23-44-30-4-2-3-28(22-30)36(37,38)39/h2-16,21-22H,17-20,23H2,1H3,(H,40,41)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245210
PNG
(US9428500, 4)
Show SMILES CN1CCN(CC1)c1ccc(cn1)-c1ccc2[nH]c3nccc(\C=C\c4ccccc4)c3c2c1
Show InChI InChI=1S/C29H27N5/c1-33-15-17-34(18-16-33)27-12-10-24(20-31-27)23-9-11-26-25(19-23)28-22(13-14-30-29(28)32-26)8-7-21-5-3-2-4-6-21/h2-14,19-20H,15-18H2,1H3,(H,30,32)/b8-7+
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245219
PNG
(US9428500, 13)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(\C=C\c4ccc(F)cc4)c3c2c1
Show InChI InChI=1S/C30H27FN4/c1-34-16-18-35(19-17-34)26-11-6-22(7-12-26)24-8-13-28-27(20-24)29-23(14-15-32-30(29)33-28)5-2-21-3-9-25(31)10-4-21/h2-15,20H,16-19H2,1H3,(H,32,33)/b5-2+
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245221
PNG
(US9428500, 15)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(-c4ccc(cc4F)-c4ccccc4)c3c2c1
Show InChI InChI=1S/C34H29FN4/c1-38-17-19-39(20-18-38)27-11-7-24(8-12-27)25-10-14-32-30(21-25)33-29(15-16-36-34(33)37-32)28-13-9-26(22-31(28)35)23-5-3-2-4-6-23/h2-16,21-22H,17-20H2,1H3,(H,36,37)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245224
PNG
(US9428500, 18)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(\C=C\c4ccccc4F)c3c2c1
Show InChI InChI=1S/C30H27FN4/c1-34-16-18-35(19-17-34)25-11-8-21(9-12-25)24-10-13-28-26(20-24)29-23(14-15-32-30(29)33-28)7-6-22-4-2-3-5-27(22)31/h2-15,20H,16-19H2,1H3,(H,32,33)/b7-6+
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245208
PNG
(US9428500, 2)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(\C=C\c4ccccc4)c3c2c1
Show InChI InChI=1S/C30H28N4/c1-33-17-19-34(20-18-33)26-12-9-23(10-13-26)25-11-14-28-27(21-25)29-24(15-16-31-30(29)32-28)8-7-22-5-3-2-4-6-22/h2-16,21H,17-20H2,1H3,(H,31,32)/b8-7+
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245232
PNG
(US9428500, 26)
Show SMILES COc1ccc(Cc2ccc(cc2)-c2ccnc3[nH]c4ccc(cc4c23)-c2ccc(cc2)N2CCN(C)CC2)c(OC)c1
Show InChI InChI=1S/C37H36N4O2/c1-40-18-20-41(21-19-40)30-12-8-26(9-13-30)28-11-15-34-33(23-28)36-32(16-17-38-37(36)39-34)27-6-4-25(5-7-27)22-29-10-14-31(42-2)24-35(29)43-3/h4-17,23-24H,18-22H2,1-3H3,(H,38,39)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245240
PNG
(US9428500, 34 | US9428500, 35)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(Nc4ccccc4[N+]([O-])=O)c3c2c1
Show InChI InChI=1S/C28H26N6O2/c1-32-14-16-33(17-15-32)21-9-6-19(7-10-21)20-8-11-23-22(18-20)27-25(12-13-29-28(27)31-23)30-24-4-2-3-5-26(24)34(35)36/h2-13,18H,14-17H2,1H3,(H2,29,30,31)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245232
PNG
(US9428500, 26)
Show SMILES COc1ccc(Cc2ccc(cc2)-c2ccnc3[nH]c4ccc(cc4c23)-c2ccc(cc2)N2CCN(C)CC2)c(OC)c1
Show InChI InChI=1S/C37H36N4O2/c1-40-18-20-41(21-19-40)30-12-8-26(9-13-30)28-11-15-34-33(23-28)36-32(16-17-38-37(36)39-34)27-6-4-25(5-7-27)22-29-10-14-31(42-2)24-35(29)43-3/h4-17,23-24H,18-22H2,1-3H3,(H,38,39)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245229
PNG
(US9428500, 23)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(-c4ccc(cc4)C(=O)c4ccccc4)c3c2c1
Show InChI InChI=1S/C35H30N4O/c1-38-19-21-39(22-20-38)29-14-11-24(12-15-29)28-13-16-32-31(23-28)33-30(17-18-36-35(33)37-32)25-7-9-27(10-8-25)34(40)26-5-3-2-4-6-26/h2-18,23H,19-22H2,1H3,(H,36,37)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245211
PNG
(US9428500, 5)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(-c4ccc(cc4)-c4ccccc4)c3c2c1
Show InChI InChI=1S/C34H30N4/c1-37-19-21-38(22-20-37)29-14-11-26(12-15-29)28-13-16-32-31(23-28)33-30(17-18-35-34(33)36-32)27-9-7-25(8-10-27)24-5-3-2-4-6-24/h2-18,23H,19-22H2,1H3,(H,35,36)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245211
PNG
(US9428500, 5)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(-c4ccc(cc4)-c4ccccc4)c3c2c1
Show InChI InChI=1S/C34H30N4/c1-37-19-21-38(22-20-37)29-14-11-26(12-15-29)28-13-16-32-31(23-28)33-30(17-18-35-34(33)36-32)27-9-7-25(8-10-27)24-5-3-2-4-6-24/h2-18,23H,19-22H2,1H3,(H,35,36)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245265
PNG
(US9428500, 59)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(N4CCN(Cc5ccccc5)CC4)c3c2c1
Show InChI InChI=1S/C33H36N6/c1-36-15-19-38(20-16-36)28-10-7-26(8-11-28)27-9-12-30-29(23-27)32-31(13-14-34-33(32)35-30)39-21-17-37(18-22-39)24-25-5-3-2-4-6-25/h2-14,23H,15-22,24H2,1H3,(H,34,35)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245227
PNG
(US9428500, 21)
Show SMILES CN1CCC(CC1)N1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(-c4ccc(Cc5ccccc5)cc4)c3c2c1
Show InChI InChI=1S/C40H41N5/c1-43-21-18-35(19-22-43)45-25-23-44(24-26-45)34-14-11-31(12-15-34)33-13-16-38-37(28-33)39-36(17-20-41-40(39)42-38)32-9-7-30(8-10-32)27-29-5-3-2-4-6-29/h2-17,20,28,35H,18-19,21-27H2,1H3,(H,41,42)
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n/an/a 700n/an/an/an/an/an/a



UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245244
PNG
(US9428500, 38)
Show SMILES COc1ccccc1C#Cc1ccnc2[nH]c3ccc(cc3c12)-c1ccc(cc1)N1CCN(C)CC1
Show InChI InChI=1S/C31H28N4O/c1-34-17-19-35(20-18-34)26-12-9-22(10-13-26)25-11-14-28-27(21-25)30-24(15-16-32-31(30)33-28)8-7-23-5-3-4-6-29(23)36-2/h3-6,9-16,21H,17-20H2,1-2H3,(H,32,33)
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n/an/a 750n/an/an/an/an/an/a



UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245257
PNG
(US9428500, 51)
Show SMILES COc1cc(C(=O)c2ccccc2)c(O)cc1-c1ccnc2[nH]c3ccc(cc3c12)-c1ccc(cc1)N1CCN(C)CC1
Show InChI InChI=1S/C36H32N4O3/c1-39-16-18-40(19-17-39)26-11-8-23(9-12-26)25-10-13-31-29(20-25)34-27(14-15-37-36(34)38-31)28-21-32(41)30(22-33(28)43-2)35(42)24-6-4-3-5-7-24/h3-15,20-22,41H,16-19H2,1-2H3,(H,37,38)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245254
PNG
(US9428500, 48)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(-c4ccc(Oc5ccccc5)cc4)c3c2c1
Show InChI InChI=1S/C34H30N4O/c1-37-19-21-38(22-20-37)27-12-7-24(8-13-27)26-11-16-32-31(23-26)33-30(17-18-35-34(33)36-32)25-9-14-29(15-10-25)39-28-5-3-2-4-6-28/h2-18,23H,19-22H2,1H3,(H,35,36)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245225
PNG
(US9428500, 19)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(\C=C\c4ccccc4Cl)c3c2c1
Show InChI InChI=1S/C30H27ClN4/c1-34-16-18-35(19-17-34)25-11-8-21(9-12-25)24-10-13-28-26(20-24)29-23(14-15-32-30(29)33-28)7-6-22-4-2-3-5-27(22)31/h2-15,20H,16-19H2,1H3,(H,32,33)/b7-6+
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n/an/a 880n/an/an/an/an/an/a



UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245228
PNG
(US9428500, 22)
Show SMILES CN1CCC(CC1)N1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(\C=C\c4ccccc4C(F)(F)F)c3c2c1
Show InChI InChI=1S/C36H36F3N5/c1-42-18-15-30(16-19-42)44-22-20-43(21-23-44)29-11-8-25(9-12-29)28-10-13-33-31(24-28)34-27(14-17-40-35(34)41-33)7-6-26-4-2-3-5-32(26)36(37,38)39/h2-14,17,24,30H,15-16,18-23H2,1H3,(H,40,41)/b7-6+
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245246
PNG
(US9428500, 40)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(C#Cc4ccc(F)cc4)c3c2c1
Show InChI InChI=1S/C30H25FN4/c1-34-16-18-35(19-17-34)26-11-6-22(7-12-26)24-8-13-28-27(20-24)29-23(14-15-32-30(29)33-28)5-2-21-3-9-25(31)10-4-21/h3-4,6-15,20H,16-19H2,1H3,(H,32,33)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245242
PNG
(US9428500, 36)
Show SMILES CN1CCC(CC1)N1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(Nc4ccccc4[N+]([O-])=O)c3c2c1
Show InChI InChI=1S/C33H35N7O2/c1-37-16-13-26(14-17-37)39-20-18-38(19-21-39)25-9-6-23(7-10-25)24-8-11-28-27(22-24)32-30(12-15-34-33(32)36-28)35-29-4-2-3-5-31(29)40(41)42/h2-12,15,22,26H,13-14,16-21H2,1H3,(H2,34,35,36)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245214
PNG
(US9428500, 8)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(-c4ccc(OCc5ccccc5)cc4)c3c2c1
Show InChI InChI=1S/C35H32N4O/c1-38-19-21-39(22-20-38)29-12-7-26(8-13-29)28-11-16-33-32(23-28)34-31(17-18-36-35(34)37-33)27-9-14-30(15-10-27)40-24-25-5-3-2-4-6-25/h2-18,23H,19-22,24H2,1H3,(H,36,37)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245226
PNG
(US9428500, 20)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(-c4ccc(cc4)N4CCN(C)CC4)c3c2c1
Show InChI InChI=1S/C33H36N6/c1-36-15-19-38(20-16-36)27-8-3-24(4-9-27)26-7-12-31-30(23-26)32-29(13-14-34-33(32)35-31)25-5-10-28(11-6-25)39-21-17-37(2)18-22-39/h3-14,23H,15-22H2,1-2H3,(H,34,35)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245251
PNG
(US9428500, 45)
Show SMILES COc1ccccc1C#Cc1ccnc2n(C)c3ccc(cc3c12)-c1ccc(cc1)N1CCN(C)CC1
Show InChI InChI=1S/C32H30N4O/c1-34-18-20-36(21-19-34)27-13-10-23(11-14-27)26-12-15-29-28(22-26)31-25(16-17-33-32(31)35(29)2)9-8-24-6-4-5-7-30(24)37-3/h4-7,10-17,22H,18-21H2,1-3H3
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245255
PNG
(US9428500, 49)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(-c4ccc(nc4)-c4ccc(F)cc4)c3c2c1
Show InChI InChI=1S/C33H28FN5/c1-38-16-18-39(19-17-38)27-10-4-22(5-11-27)24-6-13-31-29(20-24)32-28(14-15-35-33(32)37-31)25-7-12-30(36-21-25)23-2-8-26(34)9-3-23/h2-15,20-21H,16-19H2,1H3,(H,35,37)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245221
PNG
(US9428500, 15)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(-c4ccc(cc4F)-c4ccccc4)c3c2c1
Show InChI InChI=1S/C34H29FN4/c1-38-17-19-39(20-18-38)27-11-7-24(8-12-27)25-10-14-32-30(21-25)33-29(15-16-36-34(33)37-32)28-13-9-26(22-31(28)35)23-5-3-2-4-6-23/h2-16,21-22H,17-20H2,1H3,(H,36,37)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245236
PNG
(US9428500, 30 | US9428500, 31)
Show SMILES CC\C=C(/c1ccccc1)c1ccnc2[nH]c3ccc(cc3c12)-c1ccc(cc1)N1CCN(C)CC1
Show InChI InChI=1S/C32H32N4/c1-3-7-27(24-8-5-4-6-9-24)28-16-17-33-32-31(28)29-22-25(12-15-30(29)34-32)23-10-13-26(14-11-23)36-20-18-35(2)19-21-36/h4-17,22H,3,18-21H2,1-2H3,(H,33,34)/b27-7+
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245265
PNG
(US9428500, 59)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(N4CCN(Cc5ccccc5)CC4)c3c2c1
Show InChI InChI=1S/C33H36N6/c1-36-15-19-38(20-16-36)28-10-7-26(8-11-28)27-9-12-30-29(23-27)32-31(13-14-34-33(32)35-30)39-21-17-37(18-22-39)24-25-5-3-2-4-6-25/h2-14,23H,15-22,24H2,1H3,(H,34,35)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245207
PNG
(US9428500, 1)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(Cl)c3c2c1
Show InChI InChI=1S/C22H21ClN4/c1-26-10-12-27(13-11-26)17-5-2-15(3-6-17)16-4-7-20-18(14-16)21-19(23)8-9-24-22(21)25-20/h2-9,14H,10-13H2,1H3,(H,24,25)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245245
PNG
(US9428500, 39)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(C#Cc4ccccc4C(F)(F)F)c3c2c1
Show InChI InChI=1S/C31H25F3N4/c1-37-16-18-38(19-17-37)25-11-8-21(9-12-25)24-10-13-28-26(20-24)29-23(14-15-35-30(29)36-28)7-6-22-4-2-3-5-27(22)31(32,33)34/h2-5,8-15,20H,16-19H2,1H3,(H,35,36)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245247
PNG
(US9428500, 41)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(C#Cc4ccccc4F)c3c2c1
Show InChI InChI=1S/C30H25FN4/c1-34-16-18-35(19-17-34)25-11-8-21(9-12-25)24-10-13-28-26(20-24)29-23(14-15-32-30(29)33-28)7-6-22-4-2-3-5-27(22)31/h2-5,8-15,20H,16-19H2,1H3,(H,32,33)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245248
PNG
(US9428500, 42)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(C#Cc4ccccc4Cl)c3c2c1
Show InChI InChI=1S/C30H25ClN4/c1-34-16-18-35(19-17-34)25-11-8-21(9-12-25)24-10-13-28-26(20-24)29-23(14-15-32-30(29)33-28)7-6-22-4-2-3-5-27(22)31/h2-5,8-15,20H,16-19H2,1H3,(H,32,33)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245213
PNG
(US9428500, 7)
Show SMILES COc1ccc(\C=C\c2ccnc3[nH]c4ccc(cc4c23)-c2ccc(cc2)N2CCN(C)CC2)cc1
Show InChI InChI=1S/C31H30N4O/c1-34-17-19-35(20-18-34)26-10-7-23(8-11-26)25-9-14-29-28(21-25)30-24(15-16-32-31(30)33-29)6-3-22-4-12-27(36-2)13-5-22/h3-16,21H,17-20H2,1-2H3,(H,32,33)/b6-3+
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245231
PNG
(US9428500, 25)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(\C(=C\c4ccccc4)c4ccccc4)c3c2c1
Show InChI InChI=1S/C36H32N4/c1-39-20-22-40(23-21-39)30-15-12-27(13-16-30)29-14-17-34-33(25-29)35-31(18-19-37-36(35)38-34)32(28-10-6-3-7-11-28)24-26-8-4-2-5-9-26/h2-19,24-25H,20-23H2,1H3,(H,37,38)/b32-24+
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245259
PNG
(US9428500, 53)
Show SMILES COc1cc(Cc2ccccc2)c(O)cc1-c1ccnc2[nH]c3ccc(cc3c12)-c1ccc(cc1)N1CCN(C)CC1
Show InChI InChI=1S/C36H34N4O2/c1-39-16-18-40(19-17-39)28-11-8-25(9-12-28)26-10-13-32-31(21-26)35-29(14-15-37-36(35)38-32)30-23-33(41)27(22-34(30)42-2)20-24-6-4-3-5-7-24/h3-15,21-23,41H,16-20H2,1-2H3,(H,37,38)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245239
PNG
(US9428500, 33)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(-c4ccc(cc4)C(O)c4ccccc4)c3c2c1
Show InChI InChI=1S/C35H32N4O/c1-38-19-21-39(22-20-38)29-14-11-24(12-15-29)28-13-16-32-31(23-28)33-30(17-18-36-35(33)37-32)25-7-9-27(10-8-25)34(40)26-5-3-2-4-6-26/h2-18,23,34,40H,19-22H2,1H3,(H,36,37)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245236
PNG
(US9428500, 30 | US9428500, 31)
Show SMILES CC\C=C(/c1ccccc1)c1ccnc2[nH]c3ccc(cc3c12)-c1ccc(cc1)N1CCN(C)CC1
Show InChI InChI=1S/C32H32N4/c1-3-7-27(24-8-5-4-6-9-24)28-16-17-33-32-31(28)29-22-25(12-15-30(29)34-32)23-10-13-26(14-11-23)36-20-18-35(2)19-21-36/h4-17,22H,3,18-21H2,1-2H3,(H,33,34)/b27-7+
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245236
PNG
(US9428500, 30 | US9428500, 31)
Show SMILES CC\C=C(/c1ccccc1)c1ccnc2[nH]c3ccc(cc3c12)-c1ccc(cc1)N1CCN(C)CC1
Show InChI InChI=1S/C32H32N4/c1-3-7-27(24-8-5-4-6-9-24)28-16-17-33-32-31(28)29-22-25(12-15-30(29)34-32)23-10-13-26(14-11-23)36-20-18-35(2)19-21-36/h4-17,22H,3,18-21H2,1-2H3,(H,33,34)/b27-7+
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245233
PNG
(US9428500, 27)
Show SMILES COc1ccccc1\C=C(/C)c1ccnc2[nH]c3ccc(cc3c12)-c1ccc(cc1)N1CCN(C)CC1
Show InChI InChI=1S/C32H32N4O/c1-22(20-25-6-4-5-7-30(25)37-3)27-14-15-33-32-31(27)28-21-24(10-13-29(28)34-32)23-8-11-26(12-9-23)36-18-16-35(2)17-19-36/h4-15,20-21H,16-19H2,1-3H3,(H,33,34)/b22-20+
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245227
PNG
(US9428500, 21)
Show SMILES CN1CCC(CC1)N1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(-c4ccc(Cc5ccccc5)cc4)c3c2c1
Show InChI InChI=1S/C40H41N5/c1-43-21-18-35(19-22-43)45-25-23-44(24-26-45)34-14-11-31(12-15-34)33-13-16-38-37(28-33)39-36(17-20-41-40(39)42-38)32-9-7-30(8-10-32)27-29-5-3-2-4-6-29/h2-17,20,28,35H,18-19,21-27H2,1H3,(H,41,42)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245231
PNG
(US9428500, 25)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(\C(=C\c4ccccc4)c4ccccc4)c3c2c1
Show InChI InChI=1S/C36H32N4/c1-39-20-22-40(23-21-39)30-15-12-27(13-16-30)29-14-17-34-33(25-29)35-31(18-19-37-36(35)38-34)32(28-10-6-3-7-11-28)24-26-8-4-2-5-9-26/h2-19,24-25H,20-23H2,1H3,(H,37,38)/b32-24+
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245215
PNG
(US9428500, 9)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(-c4ccc(COc5cccc(c5)C(F)(F)F)cc4)c3c2c1
Show InChI InChI=1S/C36H31F3N4O/c1-42-17-19-43(20-18-42)29-12-9-25(10-13-29)27-11-14-33-32(21-27)34-31(15-16-40-35(34)41-33)26-7-5-24(6-8-26)23-44-30-4-2-3-28(22-30)36(37,38)39/h2-16,21-22H,17-20,23H2,1H3,(H,40,41)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245255
PNG
(US9428500, 49)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(-c4ccc(nc4)-c4ccc(F)cc4)c3c2c1
Show InChI InChI=1S/C33H28FN5/c1-38-16-18-39(19-17-38)27-10-4-22(5-11-27)24-6-13-31-29(20-24)32-28(14-15-35-33(32)37-31)25-7-12-30(36-21-25)23-2-8-26(34)9-3-23/h2-15,20-21H,16-19H2,1H3,(H,35,37)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245233
PNG
(US9428500, 27)
Show SMILES COc1ccccc1\C=C(/C)c1ccnc2[nH]c3ccc(cc3c12)-c1ccc(cc1)N1CCN(C)CC1
Show InChI InChI=1S/C32H32N4O/c1-22(20-25-6-4-5-7-30(25)37-3)27-14-15-33-32-31(27)28-21-24(10-13-29(28)34-32)23-8-11-26(12-9-23)36-18-16-35(2)17-19-36/h4-15,20-21H,16-19H2,1-3H3,(H,33,34)/b22-20+
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245240
PNG
(US9428500, 34 | US9428500, 35)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(Nc4ccccc4[N+]([O-])=O)c3c2c1
Show InChI InChI=1S/C28H26N6O2/c1-32-14-16-33(17-15-32)21-9-6-19(7-10-21)20-8-11-23-22(18-20)27-25(12-13-29-28(27)31-23)30-24-4-2-3-5-26(24)34(35)36/h2-13,18H,14-17H2,1H3,(H2,29,30,31)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245260
PNG
(US9428500, 54)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(-c4ccc(Cc5ccccc5)c(c4)C(F)(F)F)c3c2c1
Show InChI InChI=1S/C36H31F3N4/c1-42-17-19-43(20-18-42)29-12-9-25(10-13-29)26-11-14-33-31(22-26)34-30(15-16-40-35(34)41-33)27-7-8-28(32(23-27)36(37,38)39)21-24-5-3-2-4-6-24/h2-16,22-23H,17-21H2,1H3,(H,40,41)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245207
PNG
(US9428500, 1)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(Cl)c3c2c1
Show InChI InChI=1S/C22H21ClN4/c1-26-10-12-27(13-11-26)17-5-2-15(3-6-17)16-4-7-20-18(14-16)21-19(23)8-9-24-22(21)25-20/h2-9,14H,10-13H2,1H3,(H,24,25)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245260
PNG
(US9428500, 54)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(-c4ccc(Cc5ccccc5)c(c4)C(F)(F)F)c3c2c1
Show InChI InChI=1S/C36H31F3N4/c1-42-17-19-43(20-18-42)29-12-9-25(10-13-29)26-11-14-33-31(22-26)34-30(15-16-40-35(34)41-33)27-7-8-28(32(23-27)36(37,38)39)21-24-5-3-2-4-6-24/h2-16,22-23H,17-21H2,1H3,(H,40,41)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245214
PNG
(US9428500, 8)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(-c4ccc(OCc5ccccc5)cc4)c3c2c1
Show InChI InChI=1S/C35H32N4O/c1-38-19-21-39(22-20-38)29-12-7-26(8-13-29)28-11-16-33-32(23-28)34-31(17-18-36-35(34)37-33)27-9-14-30(15-10-27)40-24-25-5-3-2-4-6-25/h2-18,23H,19-22,24H2,1H3,(H,36,37)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245253
PNG
(US9428500, 47)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(-c4cn(Cc5ccc(C)cc5)nn4)c3c2c1
Show InChI InChI=1S/C32H31N7/c1-22-3-5-23(6-4-22)20-39-21-30(35-36-39)27-13-14-33-32-31(27)28-19-25(9-12-29(28)34-32)24-7-10-26(11-8-24)38-17-15-37(2)16-18-38/h3-14,19,21H,15-18,20H2,1-2H3,(H,33,34)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245236
PNG
(US9428500, 30 | US9428500, 31)
Show SMILES CC\C=C(/c1ccccc1)c1ccnc2[nH]c3ccc(cc3c12)-c1ccc(cc1)N1CCN(C)CC1
Show InChI InChI=1S/C32H32N4/c1-3-7-27(24-8-5-4-6-9-24)28-16-17-33-32-31(28)29-22-25(12-15-30(29)34-32)23-10-13-26(14-11-23)36-20-18-35(2)19-21-36/h4-17,22H,3,18-21H2,1-2H3,(H,33,34)/b27-7+
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245256
PNG
(US9428500, 50)
Show SMILES COc1cc(c(OC)cc1C(=O)c1ccccc1)-c1ccnc2[nH]c3ccc(cc3c12)-c1ccc(cc1)N1CCN(C)CC1
Show InChI InChI=1S/C37H34N4O3/c1-40-17-19-41(20-18-40)27-12-9-24(10-13-27)26-11-14-32-30(21-26)35-28(15-16-38-37(35)39-32)29-22-34(44-3)31(23-33(29)43-2)36(42)25-7-5-4-6-8-25/h4-16,21-23H,17-20H2,1-3H3,(H,38,39)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245257
PNG
(US9428500, 51)
Show SMILES COc1cc(C(=O)c2ccccc2)c(O)cc1-c1ccnc2[nH]c3ccc(cc3c12)-c1ccc(cc1)N1CCN(C)CC1
Show InChI InChI=1S/C36H32N4O3/c1-39-16-18-40(19-17-39)26-11-8-23(9-12-26)25-10-13-31-29(20-25)34-27(14-15-37-36(34)38-31)28-21-32(41)30(22-33(28)43-2)35(42)24-6-4-3-5-7-24/h3-15,20-22,41H,16-19H2,1-2H3,(H,37,38)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245228
PNG
(US9428500, 22)
Show SMILES CN1CCC(CC1)N1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(\C=C\c4ccccc4C(F)(F)F)c3c2c1
Show InChI InChI=1S/C36H36F3N5/c1-42-18-15-30(16-19-42)44-22-20-43(21-23-44)29-11-8-25(9-12-29)28-10-13-33-31(24-28)34-27(14-17-40-35(34)41-33)7-6-26-4-2-3-5-32(26)36(37,38)39/h2-14,17,24,30H,15-16,18-23H2,1H3,(H,40,41)/b7-6+
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245238
PNG
(US9428500, 32)
Show SMILES CC(C)[Si](C=Cc1ccnc2[nH]c3ccc(cc3c12)-c1ccc(cc1)N1CCN(C)CC1)(C(C)C)C(C)C
Show InChI InChI=1S/C33H44N4Si/c1-23(2)38(24(3)4,25(5)6)21-15-27-14-16-34-33-32(27)30-22-28(10-13-31(30)35-33)26-8-11-29(12-9-26)37-19-17-36(7)18-20-37/h8-16,21-25H,17-20H2,1-7H3,(H,34,35)/b21-15+
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245261
PNG
(US9428500, 55)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(-c4ccc(Cc5ccccc5)cc4C(F)(F)F)c3c2c1
Show InChI InChI=1S/C36H31F3N4/c1-42-17-19-43(20-18-42)28-11-8-26(9-12-28)27-10-14-33-31(23-27)34-30(15-16-40-35(34)41-33)29-13-7-25(22-32(29)36(37,38)39)21-24-5-3-2-4-6-24/h2-16,22-23H,17-21H2,1H3,(H,40,41)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245240
PNG
(US9428500, 34 | US9428500, 35)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(Nc4ccccc4[N+]([O-])=O)c3c2c1
Show InChI InChI=1S/C28H26N6O2/c1-32-14-16-33(17-15-32)21-9-6-19(7-10-21)20-8-11-23-22(18-20)27-25(12-13-29-28(27)31-23)30-24-4-2-3-5-26(24)34(35)36/h2-13,18H,14-17H2,1H3,(H2,29,30,31)
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n/an/a 3.30E+3n/an/an/an/an/an/a



UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245251
PNG
(US9428500, 45)
Show SMILES COc1ccccc1C#Cc1ccnc2n(C)c3ccc(cc3c12)-c1ccc(cc1)N1CCN(C)CC1
Show InChI InChI=1S/C32H30N4O/c1-34-18-20-36(21-19-34)27-13-10-23(11-14-27)26-12-15-29-28(22-26)31-25(16-17-33-32(31)35(29)2)9-8-24-6-4-5-7-30(24)37-3/h4-7,10-17,22H,18-21H2,1-3H3
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n/an/a 3.80E+3n/an/an/an/an/an/a



UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245259
PNG
(US9428500, 53)
Show SMILES COc1cc(Cc2ccccc2)c(O)cc1-c1ccnc2[nH]c3ccc(cc3c12)-c1ccc(cc1)N1CCN(C)CC1
Show InChI InChI=1S/C36H34N4O2/c1-39-16-18-40(19-17-39)28-11-8-25(9-12-28)26-10-13-32-31(21-26)35-29(14-15-37-36(35)38-32)30-23-33(41)27(22-34(30)42-2)20-24-6-4-3-5-7-24/h3-15,21-23,41H,16-20H2,1-2H3,(H,37,38)
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n/an/a 4.30E+3n/an/an/an/an/an/a



UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245249
PNG
(US9428500, 43)
Show SMILES CC(C)[Si](C#Cc1ccnc2[nH]c3ccc(cc3c12)-c1ccc(cc1)N1CCN(C)CC1)(C(C)C)C(C)C
Show InChI InChI=1S/C33H42N4Si/c1-23(2)38(24(3)4,25(5)6)21-15-27-14-16-34-33-32(27)30-22-28(10-13-31(30)35-33)26-8-11-29(12-9-26)37-19-17-36(7)18-20-37/h8-14,16,22-25H,17-20H2,1-7H3,(H,34,35)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245252
PNG
(US9428500, 46)
Show SMILES COc1ccc(Sc2ccnc3[nH]c4ccc(cc4c23)-c2ccc(cc2)N2CCN(C)CC2)cc1
Show InChI InChI=1S/C29H28N4OS/c1-32-15-17-33(18-16-32)22-6-3-20(4-7-22)21-5-12-26-25(19-21)28-27(13-14-30-29(28)31-26)35-24-10-8-23(34-2)9-11-24/h3-14,19H,15-18H2,1-2H3,(H,30,31)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245249
PNG
(US9428500, 43)
Show SMILES CC(C)[Si](C#Cc1ccnc2[nH]c3ccc(cc3c12)-c1ccc(cc1)N1CCN(C)CC1)(C(C)C)C(C)C
Show InChI InChI=1S/C33H42N4Si/c1-23(2)38(24(3)4,25(5)6)21-15-27-14-16-34-33-32(27)30-22-28(10-13-31(30)35-33)26-8-11-29(12-9-26)37-19-17-36(7)18-20-37/h8-14,16,22-25H,17-20H2,1-7H3,(H,34,35)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245209
PNG
(US9428500, 3)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(\C(C)=C\c4ccccc4C(F)(F)F)c3c2c1
Show InChI InChI=1S/C32H29F3N4/c1-21(19-24-5-3-4-6-28(24)32(33,34)35)26-13-14-36-31-30(26)27-20-23(9-12-29(27)37-31)22-7-10-25(11-8-22)39-17-15-38(2)16-18-39/h3-14,19-20H,15-18H2,1-2H3,(H,36,37)/b21-19+
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245253
PNG
(US9428500, 47)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(-c4cn(Cc5ccc(C)cc5)nn4)c3c2c1
Show InChI InChI=1S/C32H31N7/c1-22-3-5-23(6-4-22)20-39-21-30(35-36-39)27-13-14-33-32-31(27)28-19-25(9-12-29(28)34-32)24-7-10-26(11-8-24)38-17-15-37(2)16-18-38/h3-14,19,21H,15-18,20H2,1-2H3,(H,33,34)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245238
PNG
(US9428500, 32)
Show SMILES CC(C)[Si](C=Cc1ccnc2[nH]c3ccc(cc3c12)-c1ccc(cc1)N1CCN(C)CC1)(C(C)C)C(C)C
Show InChI InChI=1S/C33H44N4Si/c1-23(2)38(24(3)4,25(5)6)21-15-27-14-16-34-33-32(27)30-22-28(10-13-31(30)35-33)26-8-11-29(12-9-26)37-19-17-36(7)18-20-37/h8-16,21-25H,17-20H2,1-7H3,(H,34,35)/b21-15+
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245254
PNG
(US9428500, 48)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(-c4ccc(Oc5ccccc5)cc4)c3c2c1
Show InChI InChI=1S/C34H30N4O/c1-37-19-21-38(22-20-37)27-12-7-24(8-13-27)26-11-16-32-31(23-26)33-30(17-18-35-34(33)36-32)25-9-14-29(15-10-25)39-28-5-3-2-4-6-28/h2-18,23H,19-22H2,1H3,(H,35,36)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245209
PNG
(US9428500, 3)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(\C(C)=C\c4ccccc4C(F)(F)F)c3c2c1
Show InChI InChI=1S/C32H29F3N4/c1-21(19-24-5-3-4-6-28(24)32(33,34)35)26-13-14-36-31-30(26)27-20-23(9-12-29(27)37-31)22-7-10-25(11-8-22)39-17-15-38(2)16-18-39/h3-14,19-20H,15-18H2,1-2H3,(H,36,37)/b21-19+
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245261
PNG
(US9428500, 55)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(-c4ccc(Cc5ccccc5)cc4C(F)(F)F)c3c2c1
Show InChI InChI=1S/C36H31F3N4/c1-42-17-19-43(20-18-42)28-11-8-26(9-12-28)27-10-14-33-31(23-27)34-30(15-16-40-35(34)41-33)29-13-7-25(22-32(29)36(37,38)39)21-24-5-3-2-4-6-24/h2-16,22-23H,17-21H2,1H3,(H,40,41)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245262
PNG
(US9428500, 56)
Show SMILES COc1cc(cc(OC)c1Cc1ccccc1)-c1ccnc2[nH]c3ccc(cc3c12)-c1ccc(cc1)N1CCN(C)CC1
Show InChI InChI=1S/C37H36N4O2/c1-40-17-19-41(20-18-40)29-12-9-26(10-13-29)27-11-14-33-31(22-27)36-30(15-16-38-37(36)39-33)28-23-34(42-2)32(35(24-28)43-3)21-25-7-5-4-6-8-25/h4-16,22-24H,17-21H2,1-3H3,(H,38,39)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245256
PNG
(US9428500, 50)
Show SMILES COc1cc(c(OC)cc1C(=O)c1ccccc1)-c1ccnc2[nH]c3ccc(cc3c12)-c1ccc(cc1)N1CCN(C)CC1
Show InChI InChI=1S/C37H34N4O3/c1-40-17-19-41(20-18-40)27-12-9-24(10-13-27)26-11-14-32-30(21-26)35-28(15-16-38-37(35)39-32)29-22-34(44-3)31(23-33(29)43-2)36(42)25-7-5-4-6-8-25/h4-16,21-23H,17-20H2,1-3H3,(H,38,39)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245242
PNG
(US9428500, 36)
Show SMILES CN1CCC(CC1)N1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(Nc4ccccc4[N+]([O-])=O)c3c2c1
Show InChI InChI=1S/C33H35N7O2/c1-37-16-13-26(14-17-37)39-20-18-38(19-21-39)25-9-6-23(7-10-25)24-8-11-28-27(22-24)32-30(12-15-34-33(32)36-28)35-29-4-2-3-5-31(29)40(41)42/h2-12,15,22,26H,13-14,16-21H2,1H3,(H2,34,35,36)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245263
PNG
(US9428500, 57)
Show SMILES COc1cc(c(OC)cc1C(O)c1ccccc1)-c1ccnc2[nH]c3ccc(cc3c12)-c1ccc(cc1)N1CCN(C)CC1
Show InChI InChI=1S/C37H36N4O3/c1-40-17-19-41(20-18-40)27-12-9-24(10-13-27)26-11-14-32-30(21-26)35-28(15-16-38-37(35)39-32)29-22-34(44-3)31(23-33(29)43-2)36(42)25-7-5-4-6-8-25/h4-16,21-23,36,42H,17-20H2,1-3H3,(H,38,39)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245252
PNG
(US9428500, 46)
Show SMILES COc1ccc(Sc2ccnc3[nH]c4ccc(cc4c23)-c2ccc(cc2)N2CCN(C)CC2)cc1
Show InChI InChI=1S/C29H28N4OS/c1-32-15-17-33(18-16-32)22-6-3-20(4-7-22)21-5-12-26-25(19-21)28-27(13-14-30-29(28)31-26)35-24-10-8-23(34-2)9-11-24/h3-14,19H,15-18H2,1-2H3,(H,30,31)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245226
PNG
(US9428500, 20)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(-c4ccc(cc4)N4CCN(C)CC4)c3c2c1
Show InChI InChI=1S/C33H36N6/c1-36-15-19-38(20-16-36)27-8-3-24(4-9-27)26-7-12-31-30(23-26)32-29(13-14-34-33(32)35-31)25-5-10-28(11-6-25)39-21-17-37(2)18-22-39/h3-14,23H,15-22H2,1-2H3,(H,34,35)
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UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245263
PNG
(US9428500, 57)
Show SMILES COc1cc(c(OC)cc1C(O)c1ccccc1)-c1ccnc2[nH]c3ccc(cc3c12)-c1ccc(cc1)N1CCN(C)CC1
Show InChI InChI=1S/C37H36N4O3/c1-40-17-19-41(20-18-40)27-12-9-24(10-13-27)26-11-14-32-30(21-26)35-28(15-16-38-37(35)39-32)29-22-34(44-3)31(23-33(29)43-2)36(42)25-7-5-4-6-8-25/h4-16,21-23,36,42H,17-20H2,1-3H3,(H,38,39)
PDB

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UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 1.80E+4n/an/an/an/an/an/a



UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245262
PNG
(US9428500, 56)
Show SMILES COc1cc(cc(OC)c1Cc1ccccc1)-c1ccnc2[nH]c3ccc(cc3c12)-c1ccc(cc1)N1CCN(C)CC1
Show InChI InChI=1S/C37H36N4O2/c1-40-17-19-41(20-18-40)29-12-9-26(10-13-29)27-11-14-33-31(22-27)36-30(15-16-38-37(36)39-33)28-23-34(42-2)32(35(24-28)43-3)21-25-7-5-4-6-8-25/h4-16,22-24H,17-21H2,1-3H3,(H,38,39)
PDB
MMDB

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UniChem
US Patent
n/an/a 1.90E+4n/an/an/an/an/an/a



UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM245250
PNG
(US9428500, 44)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(C#C)c3c2c1
Show InChI InChI=1S/C24H22N4/c1-3-17-10-11-25-24-23(17)21-16-19(6-9-22(21)26-24)18-4-7-20(8-5-18)28-14-12-27(2)13-15-28/h1,4-11,16H,12-15H2,2H3,(H,25,26)
PDB

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UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 2.90E+4n/an/an/an/an/an/a



UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor (L1196M)


(Homo sapiens (Human))
BDBM245250
PNG
(US9428500, 44)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2[nH]c3nccc(C#C)c3c2c1
Show InChI InChI=1S/C24H22N4/c1-3-17-10-11-25-24-23(17)21-16-19(6-9-22(21)26-24)18-4-7-20(8-5-18)28-14-12-27(2)13-15-28/h1,4-11,16H,12-15H2,2H3,(H,25,26)
PDB
MMDB

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.30E+4n/an/an/an/an/an/a



UNIVERSITA DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITE DE GENEVE; UNIVERSITE CLAUDE BERNARD—LYON

US Patent


Assay Description
GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%