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Patent code US9428508

Compile Data Set for Download or QSAR

Found 324 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
PTK2B protein tyrosine kinase 2 beta (PTK2B)


(Homo sapiens (Human))
BDBM245693
PNG
(US9428508, 148)
Show SMILES CCCNS(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(cc2OC)N2CCOCC2)nc2NCC3(CC3)c12
Show InChI InChI=1S/C28H35N7O4S/c1-3-12-30-40(36,37)23-7-5-4-6-21(23)31-26-24-25(29-18-28(24)10-11-28)33-27(34-26)32-20-9-8-19(17-22(20)38-2)35-13-15-39-16-14-35/h4-9,17,30H,3,10-16,18H2,1-2H3,(H3,29,31,32,33,34)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
To measure inhibitory activity of FAK/PYK2 inhibitors, compounds were first prepare as a 1 mM stock in 100% DMSO and 3-fold serial dilution was perfo...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM245589
PNG
(US9428508, 44)
Show SMILES CCC(C)NS(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(cc2OC)N2CCOCC2)nc2NCCc12
Show InChI InChI=1S/C27H35N7O4S/c1-4-18(2)33-39(35,36)24-8-6-5-7-22(24)29-26-20-11-12-28-25(20)31-27(32-26)30-21-10-9-19(17-23(21)37-3)34-13-15-38-16-14-34/h5-10,17-18,33H,4,11-16H2,1-3H3,(H3,28,29,30,31,32)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
To measure inhibitory activity of FAK/PYK2 inhibitors, compounds were first prepare as a 1 mM stock in 100% DMSO and 3-fold serial dilution was perfo...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM245585
PNG
(US9428508, 40 | US9428508, 46)
Show SMILES COc1cc(ccc1Nc1nc2NCCc2c(Nc2ccccc2S(=O)(=O)NC(C)C)n1)N1CCOCC1
Show InChI InChI=1S/C26H33N7O4S/c1-17(2)32-38(34,35)23-7-5-4-6-21(23)28-25-19-10-11-27-24(19)30-26(31-25)29-20-9-8-18(16-22(20)36-3)33-12-14-37-15-13-33/h4-9,16-17,32H,10-15H2,1-3H3,(H3,27,28,29,30,31)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
To measure inhibitory activity of FAK/PYK2 inhibitors, compounds were first prepare as a 1 mM stock in 100% DMSO and 3-fold serial dilution was perfo...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM245620
PNG
(US9428508, 75)
Show SMILES CC(C)NS(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(C)=O)c2)nc2NCCc12
Show InChI InChI=1S/C23H27N7O3S/c1-14(2)30-34(32,33)20-10-5-4-9-19(20)27-22-18-11-12-24-21(18)28-23(29-22)26-17-8-6-7-16(13-17)25-15(3)31/h4-10,13-14,30H,11-12H2,1-3H3,(H,25,31)(H3,24,26,27,28,29)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
To measure inhibitory activity of FAK/PYK2 inhibitors, compounds were first prepare as a 1 mM stock in 100% DMSO and 3-fold serial dilution was perfo...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM245621
PNG
(US9428508, 76)
Show SMILES COc1cc(ccc1Nc1nc2NCCc2c(Nc2ccccc2S(=O)(=O)NC(C)C)n1)N1CCC(CC1)N(C)C
Show InChI InChI=1S/C29H40N8O3S/c1-19(2)35-41(38,39)26-9-7-6-8-24(26)31-28-22-12-15-30-27(22)33-29(34-28)32-23-11-10-21(18-25(23)40-5)37-16-13-20(14-17-37)36(3)4/h6-11,18-20,35H,12-17H2,1-5H3,(H3,30,31,32,33,34)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
To measure inhibitory activity of FAK/PYK2 inhibitors, compounds were first prepare as a 1 mM stock in 100% DMSO and 3-fold serial dilution was perfo...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM245631
PNG
(US9428508, 86)
Show SMILES COc1cc(ccc1Nc1nc2NCCc2c(Nc2ccccc2S(=O)(=O)NC(C)C)n1)N1CCC(O)CC1
Show InChI InChI=1S/C27H35N7O4S/c1-17(2)33-39(36,37)24-7-5-4-6-22(24)29-26-20-10-13-28-25(20)31-27(32-26)30-21-9-8-18(16-23(21)38-3)34-14-11-19(35)12-15-34/h4-9,16-17,19,33,35H,10-15H2,1-3H3,(H3,28,29,30,31,32)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
To measure inhibitory activity of FAK/PYK2 inhibitors, compounds were first prepare as a 1 mM stock in 100% DMSO and 3-fold serial dilution was perfo...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM245634
PNG
(US9428508, 89)
Show SMILES COc1cc(ccc1Nc1nc2NCCc2c(Nc2ccccc2S(=O)(=O)NC(C)C)n1)N1CCC(C1)N(C)C
Show InChI InChI=1S/C28H38N8O3S/c1-18(2)34-40(37,38)25-9-7-6-8-23(25)30-27-21-12-14-29-26(21)32-28(33-27)31-22-11-10-19(16-24(22)39-5)36-15-13-20(17-36)35(3)4/h6-11,16,18,20,34H,12-15,17H2,1-5H3,(H3,29,30,31,32,33)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
To measure inhibitory activity of FAK/PYK2 inhibitors, compounds were first prepare as a 1 mM stock in 100% DMSO and 3-fold serial dilution was perfo...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM245643
PNG
(US9428508, 98)
Show SMILES COc1cc(ccc1Nc1nc2NCCc2c(Nc2ccccc2S(=O)(=O)NC(C)C)n1)N1CCCCC1=O
Show InChI InChI=1S/C27H33N7O4S/c1-17(2)33-39(36,37)23-9-5-4-8-21(23)29-26-19-13-14-28-25(19)31-27(32-26)30-20-12-11-18(16-22(20)38-3)34-15-7-6-10-24(34)35/h4-5,8-9,11-12,16-17,33H,6-7,10,13-15H2,1-3H3,(H3,28,29,30,31,32)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
To measure inhibitory activity of FAK/PYK2 inhibitors, compounds were first prepare as a 1 mM stock in 100% DMSO and 3-fold serial dilution was perfo...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM245648
PNG
(US9428508, 103)
Show SMILES CNS(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(cc2OC)N2CCOCC2)nc2NCC(C)(C)c12
Show InChI InChI=1S/C26H33N7O4S/c1-26(2)16-28-23-22(26)24(29-19-7-5-6-8-21(19)38(34,35)27-3)32-25(31-23)30-18-10-9-17(15-20(18)36-4)33-11-13-37-14-12-33/h5-10,15,27H,11-14,16H2,1-4H3,(H3,28,29,30,31,32)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
To measure inhibitory activity of FAK/PYK2 inhibitors, compounds were first prepare as a 1 mM stock in 100% DMSO and 3-fold serial dilution was perfo...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM245651
PNG
(US9428508, 106)
Show SMILES CCCNS(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(cc2OC)N2CCOCC2)nc2NCC(C)(C)c12
Show InChI InChI=1S/C28H37N7O4S/c1-5-12-30-40(36,37)23-9-7-6-8-21(23)31-26-24-25(29-18-28(24,2)3)33-27(34-26)32-20-11-10-19(17-22(20)38-4)35-13-15-39-16-14-35/h6-11,17,30H,5,12-16,18H2,1-4H3,(H3,29,31,32,33,34)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
To measure inhibitory activity of FAK/PYK2 inhibitors, compounds were first prepare as a 1 mM stock in 100% DMSO and 3-fold serial dilution was perfo...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM245676
PNG
(US9428508, 131)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2cccc3ccoc23)nc2NCC(C)(C)c12
Show InChI InChI=1S/C24H24N6O2/c1-24(2)13-26-20-18(24)21(27-16-9-5-4-8-15(16)22(31)25-3)30-23(29-20)28-17-10-6-7-14-11-12-32-19(14)17/h4-12H,13H2,1-3H3,(H,25,31)(H3,26,27,28,29,30)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
To measure inhibitory activity of FAK/PYK2 inhibitors, compounds were first prepare as a 1 mM stock in 100% DMSO and 3-fold serial dilution was perfo...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM245685
PNG
(US9428508, 140)
Show SMILES COc1cc(ccc1Nc1nc2NCC3(CC3)c2c(Nc2ccccc2S(=O)(=O)NCC2CC2)n1)N1CCOCC1
Show InChI InChI=1S/C29H35N7O4S/c1-39-23-16-20(36-12-14-40-15-13-36)8-9-21(23)33-28-34-26-25(29(10-11-29)18-30-26)27(35-28)32-22-4-2-3-5-24(22)41(37,38)31-17-19-6-7-19/h2-5,8-9,16,19,31H,6-7,10-15,17-18H2,1H3,(H3,30,32,33,34,35)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
To measure inhibitory activity of FAK/PYK2 inhibitors, compounds were first prepare as a 1 mM stock in 100% DMSO and 3-fold serial dilution was perfo...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM245695
PNG
(US9428508, 150)
Show SMILES COc1cc(ccc1Nc1nc2NCC3(CC3)c2c(Nc2ccccc2S(=O)(=O)NC2CCC2)n1)N1CCOCC1
Show InChI InChI=1S/C29H35N7O4S/c1-39-23-17-20(36-13-15-40-16-14-36)9-10-21(23)32-28-33-26-25(29(11-12-29)18-30-26)27(34-28)31-22-7-2-3-8-24(22)41(37,38)35-19-5-4-6-19/h2-3,7-10,17,19,35H,4-6,11-16,18H2,1H3,(H3,30,31,32,33,34)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
To measure inhibitory activity of FAK/PYK2 inhibitors, compounds were first prepare as a 1 mM stock in 100% DMSO and 3-fold serial dilution was perfo...


Citation and Details
More data for this
Ligand-Target Pair
PTK2B protein tyrosine kinase 2 beta (PTK2B)


(Homo sapiens (Human))
BDBM245570
PNG
(US9428508, 25)
Show SMILES CNS(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(cc2OC)N2CCOCC2)nc2NCC(C)c12
Show InChI InChI=1S/C25H31N7O4S/c1-16-15-27-23-22(16)24(28-19-6-4-5-7-21(19)37(33,34)26-2)31-25(30-23)29-18-9-8-17(14-20(18)35-3)32-10-12-36-13-11-32/h4-9,14,16,26H,10-13,15H2,1-3H3,(H3,27,28,29,30,31)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
To measure inhibitory activity of FAK/PYK2 inhibitors, compounds were first prepare as a 1 mM stock in 100% DMSO and 3-fold serial dilution was perfo...


Citation and Details
More data for this
Ligand-Target Pair
PTK2B protein tyrosine kinase 2 beta (PTK2B)


(Homo sapiens (Human))
BDBM245580
PNG
(US9428508, 35)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc(cc2OC)N2CCOCC2)nc2NC[C@@H](C)c12
Show InChI InChI=1S/C26H31N7O3/c1-16-15-28-23-22(16)24(29-19-7-5-4-6-18(19)25(34)27-2)32-26(31-23)30-20-9-8-17(14-21(20)35-3)33-10-12-36-13-11-33/h4-9,14,16H,10-13,15H2,1-3H3,(H,27,34)(H3,28,29,30,31,32)/t16-/m1/s1
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
To measure inhibitory activity of FAK/PYK2 inhibitors, compounds were first prepare as a 1 mM stock in 100% DMSO and 3-fold serial dilution was perfo...


Citation and Details
More data for this
Ligand-Target Pair
PTK2B protein tyrosine kinase 2 beta (PTK2B)


(Homo sapiens (Human))
BDBM245620
PNG
(US9428508, 75)
Show SMILES CC(C)NS(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(C)=O)c2)nc2NCCc12
Show InChI InChI=1S/C23H27N7O3S/c1-14(2)30-34(32,33)20-10-5-4-9-19(20)27-22-18-11-12-24-21(18)28-23(29-22)26-17-8-6-7-16(13-17)25-15(3)31/h4-10,13-14,30H,11-12H2,1-3H3,(H,25,31)(H3,24,26,27,28,29)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
To measure inhibitory activity of FAK/PYK2 inhibitors, compounds were first prepare as a 1 mM stock in 100% DMSO and 3-fold serial dilution was perfo...


Citation and Details
More data for this
Ligand-Target Pair
PTK2B protein tyrosine kinase 2 beta (PTK2B)


(Homo sapiens (Human))
BDBM245627
PNG
(US9428508, 82)
Show SMILES CC(C)NS(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(cc2)C(C)N2CCCCC2)nc2NCCc12
Show InChI InChI=1S/C28H37N7O2S/c1-19(2)34-38(36,37)25-10-6-5-9-24(25)31-27-23-15-16-29-26(23)32-28(33-27)30-22-13-11-21(12-14-22)20(3)35-17-7-4-8-18-35/h5-6,9-14,19-20,34H,4,7-8,15-18H2,1-3H3,(H3,29,30,31,32,33)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
To measure inhibitory activity of FAK/PYK2 inhibitors, compounds were first prepare as a 1 mM stock in 100% DMSO and 3-fold serial dilution was perfo...


Citation and Details
More data for this
Ligand-Target Pair
PTK2B protein tyrosine kinase 2 beta (PTK2B)


(Homo sapiens (Human))
BDBM245635
PNG
(US9428508, 90)
Show SMILES COc1cc(ccc1Nc1nc2NCCc2c(Nc2ccccc2S(=O)(=O)NC(C)C)n1)-n1cc(C)nc1C
Show InChI InChI=1S/C27H32N8O3S/c1-16(2)34-39(36,37)24-9-7-6-8-22(24)30-26-20-12-13-28-25(20)32-27(33-26)31-21-11-10-19(14-23(21)38-5)35-15-17(3)29-18(35)4/h6-11,14-16,34H,12-13H2,1-5H3,(H3,28,30,31,32,33)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
To measure inhibitory activity of FAK/PYK2 inhibitors, compounds were first prepare as a 1 mM stock in 100% DMSO and 3-fold serial dilution was perfo...


Citation and Details
More data for this
Ligand-Target Pair
PTK2B protein tyrosine kinase 2 beta (PTK2B)


(Homo sapiens (Human))
BDBM245637
PNG
(US9428508, 92)
Show SMILES COc1cc(ccc1Nc1nc2NCCc2c(Nc2ccccc2S(=O)(=O)NC(C)C)n1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C32H44N8O3S/c1-22(2)38-44(41,42)29-10-6-5-9-27(29)34-31-25-13-16-33-30(25)36-32(37-31)35-26-12-11-24(21-28(26)43-3)40-19-14-23(15-20-40)39-17-7-4-8-18-39/h5-6,9-12,21-23,38H,4,7-8,13-20H2,1-3H3,(H3,33,34,35,36,37)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
To measure inhibitory activity of FAK/PYK2 inhibitors, compounds were first prepare as a 1 mM stock in 100% DMSO and 3-fold serial dilution was perfo...


Citation and Details
More data for this
Ligand-Target Pair
PTK2B protein tyrosine kinase 2 beta (PTK2B)


(Homo sapiens (Human))
BDBM245646
PNG
(US9428508, 101)
Show SMILES COc1cc(ccc1Nc1nc2NCC(C)c2c(Nc2ccccc2S(=O)(=O)NC(C)C)n1)N1CCOCC1
Show InChI InChI=1S/C27H35N7O4S/c1-17(2)33-39(35,36)23-8-6-5-7-21(23)29-26-24-18(3)16-28-25(24)31-27(32-26)30-20-10-9-19(15-22(20)37-4)34-11-13-38-14-12-34/h5-10,15,17-18,33H,11-14,16H2,1-4H3,(H3,28,29,30,31,32)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
To measure inhibitory activity of FAK/PYK2 inhibitors, compounds were first prepare as a 1 mM stock in 100% DMSO and 3-fold serial dilution was perfo...


Citation and Details
More data for this
Ligand-Target Pair
PTK2B protein tyrosine kinase 2 beta (PTK2B)


(Homo sapiens (Human))
BDBM245659
PNG
(US9428508, 114)
Show SMILES COCCCNS(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(cc2OC)N2CCOCC2)nc2NCC(C)(C)c12
Show InChI InChI=1S/C29H39N7O5S/c1-29(2)19-30-26-25(29)27(32-22-8-5-6-9-24(22)42(37,38)31-12-7-15-39-3)35-28(34-26)33-21-11-10-20(18-23(21)40-4)36-13-16-41-17-14-36/h5-6,8-11,18,31H,7,12-17,19H2,1-4H3,(H3,30,32,33,34,35)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
To measure inhibitory activity of FAK/PYK2 inhibitors, compounds were first prepare as a 1 mM stock in 100% DMSO and 3-fold serial dilution was perfo...


Citation and Details
More data for this
Ligand-Target Pair
PTK2B protein tyrosine kinase 2 beta (PTK2B)


(Homo sapiens (Human))
BDBM245662
PNG
(US9428508, 117)
Show SMILES COc1cc(ccc1Nc1nc2NCC(C)(C)c2c(Nc2ccccc2S(=O)(=O)NC(C)(C)C)n1)N1CCOCC1
Show InChI InChI=1S/C29H39N7O4S/c1-28(2,3)35-41(37,38)23-10-8-7-9-21(23)31-26-24-25(30-18-29(24,4)5)33-27(34-26)32-20-12-11-19(17-22(20)39-6)36-13-15-40-16-14-36/h7-12,17,35H,13-16,18H2,1-6H3,(H3,30,31,32,33,34)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
To measure inhibitory activity of FAK/PYK2 inhibitors, compounds were first prepare as a 1 mM stock in 100% DMSO and 3-fold serial dilution was perfo...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM245551
PNG
(US9428508, 5)
Show SMILES CCCNS(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(cc2OC)N2CCOCC2)nc2NCCc12
Show InChI InChI=1S/C26H33N7O4S/c1-3-11-28-38(34,35)23-7-5-4-6-21(23)29-25-19-10-12-27-24(19)31-26(32-25)30-20-9-8-18(17-22(20)36-2)33-13-15-37-16-14-33/h4-9,17,28H,3,10-16H2,1-2H3,(H3,27,29,30,31,32)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
To measure inhibitory activity of FAK/PYK2 inhibitors, compounds were first prepare as a 1 mM stock in 100% DMSO and 3-fold serial dilution was perfo...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM245577
PNG
(US9428508, 32)
Show SMILES COc1cc(ccc1Nc1nc2NCC(C)c2c(NCc2ccccc2N(C)S(C)(=O)=O)n1)N1CCOCC1
Show InChI InChI=1S/C27H35N7O4S/c1-18-16-28-25-24(18)26(29-17-19-7-5-6-8-22(19)33(2)39(4,35)36)32-27(31-25)30-21-10-9-20(15-23(21)37-3)34-11-13-38-14-12-34/h5-10,15,18H,11-14,16-17H2,1-4H3,(H3,28,29,30,31,32)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
To measure inhibitory activity of FAK/PYK2 inhibitors, compounds were first prepare as a 1 mM stock in 100% DMSO and 3-fold serial dilution was perfo...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM245609
PNG
(US9428508, 64)
Show SMILES CNS(=O)(=O)c1ccc(Nc2nc3NCCc3c(Nc3ccccc3S(=O)(=O)NC(C)C)n2)cc1
Show InChI InChI=1S/C22H27N7O4S2/c1-14(2)29-35(32,33)19-7-5-4-6-18(19)26-21-17-12-13-24-20(17)27-22(28-21)25-15-8-10-16(11-9-15)34(30,31)23-3/h4-11,14,23,29H,12-13H2,1-3H3,(H3,24,25,26,27,28)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
To measure inhibitory activity of FAK/PYK2 inhibitors, compounds were first prepare as a 1 mM stock in 100% DMSO and 3-fold serial dilution was perfo...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM245615
PNG
(US9428508, 70)
Show SMILES COc1cc(OCCN2CCOCC2)ccc1Nc1nc2NCCc2c(Nc2ccccc2S(=O)(=O)NC(C)C)n1
Show InChI InChI=1S/C28H37N7O5S/c1-19(2)34-41(36,37)25-7-5-4-6-23(25)30-27-21-10-11-29-26(21)32-28(33-27)31-22-9-8-20(18-24(22)38-3)40-17-14-35-12-15-39-16-13-35/h4-9,18-19,34H,10-17H2,1-3H3,(H3,29,30,31,32,33)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
To measure inhibitory activity of FAK/PYK2 inhibitors, compounds were first prepare as a 1 mM stock in 100% DMSO and 3-fold serial dilution was perfo...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM245628
PNG
(US9428508, 83)
Show SMILES COc1cc(ccc1Nc1nc2NCCc2c(Nc2ccccc2S(=O)(=O)NC(C)C)n1)-n1ccccc1=O
Show InChI InChI=1S/C27H29N7O4S/c1-17(2)33-39(36,37)23-9-5-4-8-21(23)29-26-19-13-14-28-25(19)31-27(32-26)30-20-12-11-18(16-22(20)38-3)34-15-7-6-10-24(34)35/h4-12,15-17,33H,13-14H2,1-3H3,(H3,28,29,30,31,32)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
To measure inhibitory activity of FAK/PYK2 inhibitors, compounds were first prepare as a 1 mM stock in 100% DMSO and 3-fold serial dilution was perfo...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM245632
PNG
(US9428508, 87)
Show SMILES COc1cc(ccc1Nc1nc2NCCc2c(Nc2ccccc2S(=O)(=O)NC(C)C)n1)N1CCS(=O)(=O)CC1
Show InChI InChI=1S/C26H33N7O5S2/c1-17(2)32-40(36,37)23-7-5-4-6-21(23)28-25-19-10-11-27-24(19)30-26(31-25)29-20-9-8-18(16-22(20)38-3)33-12-14-39(34,35)15-13-33/h4-9,16-17,32H,10-15H2,1-3H3,(H3,27,28,29,30,31)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
To measure inhibitory activity of FAK/PYK2 inhibitors, compounds were first prepare as a 1 mM stock in 100% DMSO and 3-fold serial dilution was perfo...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM245677
PNG
(US9428508, 132)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2cc(C)nn2C)nc2NCC(C)(C)c12
Show InChI InChI=1S/C21H26N8O/c1-12-10-15(29(5)28-12)25-20-26-17-16(21(2,3)11-23-17)18(27-20)24-14-9-7-6-8-13(14)19(30)22-4/h6-10H,11H2,1-5H3,(H,22,30)(H3,23,24,25,26,27)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
To measure inhibitory activity of FAK/PYK2 inhibitors, compounds were first prepare as a 1 mM stock in 100% DMSO and 3-fold serial dilution was perfo...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM245683
PNG
(US9428508, 138)
Show SMILES COc1cc(ccc1Nc1nc2NCC3(CC3)c2c(Nc2ccccc2S(=O)(=O)NC(C)C)n1)N1CCOCC1
Show InChI InChI=1S/C28H35N7O4S/c1-18(2)34-40(36,37)23-7-5-4-6-21(23)30-26-24-25(29-17-28(24)10-11-28)32-27(33-26)31-20-9-8-19(16-22(20)38-3)35-12-14-39-15-13-35/h4-9,16,18,34H,10-15,17H2,1-3H3,(H3,29,30,31,32,33)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
To measure inhibitory activity of FAK/PYK2 inhibitors, compounds were first prepare as a 1 mM stock in 100% DMSO and 3-fold serial dilution was perfo...


Citation and Details
More data for this
Ligand-Target Pair
PTK2B protein tyrosine kinase 2 beta (PTK2B)


(Homo sapiens (Human))
BDBM245572
PNG
(US9428508, 27)
Show SMILES COc1cc(ccc1Nc1nc2NCC(C)c2c(Nc2ccccc2S(=O)(=O)NC2CCC2)n1)N1CCOCC1
Show InChI InChI=1S/C28H35N7O4S/c1-18-17-29-26-25(18)27(30-22-8-3-4-9-24(22)40(36,37)34-19-6-5-7-19)33-28(32-26)31-21-11-10-20(16-23(21)38-2)35-12-14-39-15-13-35/h3-4,8-11,16,18-19,34H,5-7,12-15,17H2,1-2H3,(H3,29,30,31,32,33)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
To measure inhibitory activity of FAK/PYK2 inhibitors, compounds were first prepare as a 1 mM stock in 100% DMSO and 3-fold serial dilution was perfo...


Citation and Details
More data for this
Ligand-Target Pair
PTK2B protein tyrosine kinase 2 beta (PTK2B)


(Homo sapiens (Human))
BDBM245680
PNG
(US9428508, 135)
Show SMILES CNS(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(cc2OC)N2CCOCC2)nc2NCC3(CC3)c12
Show InChI InChI=1S/C26H31N7O4S/c1-27-38(34,35)21-6-4-3-5-19(21)29-24-22-23(28-16-26(22)9-10-26)31-25(32-24)30-18-8-7-17(15-20(18)36-2)33-11-13-37-14-12-33/h3-8,15,27H,9-14,16H2,1-2H3,(H3,28,29,30,31,32)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
To measure inhibitory activity of FAK/PYK2 inhibitors, compounds were first prepare as a 1 mM stock in 100% DMSO and 3-fold serial dilution was perfo...


Citation and Details
More data for this
Ligand-Target Pair
PTK2B protein tyrosine kinase 2 beta (PTK2B)


(Homo sapiens (Human))
BDBM245682
PNG
(US9428508, 137)
Show SMILES COc1cc(ccc1Nc1nc2NCC3(CC3)c2c(Nc2ccccc2S(=O)(=O)NCC(C)C)n1)N1CCOCC1
Show InChI InChI=1S/C29H37N7O4S/c1-19(2)17-31-41(37,38)24-7-5-4-6-22(24)32-27-25-26(30-18-29(25)10-11-29)34-28(35-27)33-21-9-8-20(16-23(21)39-3)36-12-14-40-15-13-36/h4-9,16,19,31H,10-15,17-18H2,1-3H3,(H3,30,32,33,34,35)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
To measure inhibitory activity of FAK/PYK2 inhibitors, compounds were first prepare as a 1 mM stock in 100% DMSO and 3-fold serial dilution was perfo...


Citation and Details
More data for this
Ligand-Target Pair
PTK2B protein tyrosine kinase 2 beta (PTK2B)


(Homo sapiens (Human))
BDBM245686
PNG
(US9428508, 141)
Show SMILES COCCNS(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(cc2OC)N2CCOCC2)nc2NCC3(CC3)c12
Show InChI InChI=1S/C28H35N7O5S/c1-38-14-11-30-41(36,37)23-6-4-3-5-21(23)31-26-24-25(29-18-28(24)9-10-28)33-27(34-26)32-20-8-7-19(17-22(20)39-2)35-12-15-40-16-13-35/h3-8,17,30H,9-16,18H2,1-2H3,(H3,29,31,32,33,34)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
To measure inhibitory activity of FAK/PYK2 inhibitors, compounds were first prepare as a 1 mM stock in 100% DMSO and 3-fold serial dilution was perfo...


Citation and Details
More data for this
Ligand-Target Pair
PTK2B protein tyrosine kinase 2 beta (PTK2B)


(Homo sapiens (Human))
BDBM245689
PNG
(US9428508, 144)
Show SMILES COc1cc(ccc1Nc1nc2NCC3(CC3)c2c(Nc2ccccc2S(=O)(=O)NCC=C)n1)N1CCOCC1
Show InChI InChI=1S/C28H33N7O4S/c1-3-12-30-40(36,37)23-7-5-4-6-21(23)31-26-24-25(29-18-28(24)10-11-28)33-27(34-26)32-20-9-8-19(17-22(20)38-2)35-13-15-39-16-14-35/h3-9,17,30H,1,10-16,18H2,2H3,(H3,29,31,32,33,34)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
To measure inhibitory activity of FAK/PYK2 inhibitors, compounds were first prepare as a 1 mM stock in 100% DMSO and 3-fold serial dilution was perfo...


Citation and Details
More data for this
Ligand-Target Pair
PTK2B protein tyrosine kinase 2 beta (PTK2B)


(Homo sapiens (Human))
BDBM245702
PNG
(US9428508, 157)
Show SMILES CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(OC)c(OC)c(OC)c2)nc2NCC3(CC3)c12
Show InChI InChI=1S/C24H28N6O5S/c1-25-36(31,32)18-8-6-5-7-15(18)28-22-19-21(26-13-24(19)9-10-24)29-23(30-22)27-14-11-16(33-2)20(35-4)17(12-14)34-3/h5-8,11-12,25H,9-10,13H2,1-4H3,(H3,26,27,28,29,30)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
To measure inhibitory activity of FAK/PYK2 inhibitors, compounds were first prepare as a 1 mM stock in 100% DMSO and 3-fold serial dilution was perfo...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM245587
PNG
(US9428508, 42)
Show SMILES COc1cc(ccc1Nc1nc2NCCc2c(Nc2ccccc2S(=O)(=O)NC2CC2)n1)N1CCOCC1
Show InChI InChI=1S/C26H31N7O4S/c1-36-22-16-18(33-12-14-37-15-13-33)8-9-20(22)29-26-30-24-19(10-11-27-24)25(31-26)28-21-4-2-3-5-23(21)38(34,35)32-17-6-7-17/h2-5,8-9,16-17,32H,6-7,10-15H2,1H3,(H3,27,28,29,30,31)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
To measure inhibitory activity of FAK/PYK2 inhibitors, compounds were first prepare as a 1 mM stock in 100% DMSO and 3-fold serial dilution was perfo...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM245607
PNG
(US9428508, 62)
Show SMILES CC(C)NS(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(cc2)C(=O)N(C)C)nc2NCCc12
Show InChI InChI=1S/C24H29N7O3S/c1-15(2)30-35(33,34)20-8-6-5-7-19(20)27-22-18-13-14-25-21(18)28-24(29-22)26-17-11-9-16(10-12-17)23(32)31(3)4/h5-12,15,30H,13-14H2,1-4H3,(H3,25,26,27,28,29)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
To measure inhibitory activity of FAK/PYK2 inhibitors, compounds were first prepare as a 1 mM stock in 100% DMSO and 3-fold serial dilution was perfo...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM245610
PNG
(US9428508, 65)
Show SMILES CC(C)NS(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(cc2)C(=O)N2CCOCC2)nc2NCCc12
Show InChI InChI=1S/C26H31N7O4S/c1-17(2)32-38(35,36)22-6-4-3-5-21(22)29-24-20-11-12-27-23(20)30-26(31-24)28-19-9-7-18(8-10-19)25(34)33-13-15-37-16-14-33/h3-10,17,32H,11-16H2,1-2H3,(H3,27,28,29,30,31)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
To measure inhibitory activity of FAK/PYK2 inhibitors, compounds were first prepare as a 1 mM stock in 100% DMSO and 3-fold serial dilution was perfo...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM245614
PNG
(US9428508, 69)
Show SMILES CC(C)NS(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(cc2)C(C)O)nc2NCCc12
Show InChI InChI=1S/C23H28N6O3S/c1-14(2)29-33(31,32)20-7-5-4-6-19(20)26-22-18-12-13-24-21(18)27-23(28-22)25-17-10-8-16(9-11-17)15(3)30/h4-11,14-15,29-30H,12-13H2,1-3H3,(H3,24,25,26,27,28)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
To measure inhibitory activity of FAK/PYK2 inhibitors, compounds were first prepare as a 1 mM stock in 100% DMSO and 3-fold serial dilution was perfo...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM245619
PNG
(US9428508, 74)
Show SMILES CNC(=O)c1cccc(Nc2nc3NCCc3c(Nc3ccccc3S(=O)(=O)NC(C)C)n2)c1
Show InChI InChI=1S/C23H27N7O3S/c1-14(2)30-34(32,33)19-10-5-4-9-18(19)27-21-17-11-12-25-20(17)28-23(29-21)26-16-8-6-7-15(13-16)22(31)24-3/h4-10,13-14,30H,11-12H2,1-3H3,(H,24,31)(H3,25,26,27,28,29)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
To measure inhibitory activity of FAK/PYK2 inhibitors, compounds were first prepare as a 1 mM stock in 100% DMSO and 3-fold serial dilution was perfo...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM245647
PNG
(US9428508, 102)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc(cc2OC)N2CCOCC2)nc2NC[C@H](C)c12
Show InChI InChI=1S/C26H31N7O3/c1-16-15-28-23-22(16)24(29-19-7-5-4-6-18(19)25(34)27-2)32-26(31-23)30-20-9-8-17(14-21(20)35-3)33-10-12-36-13-11-33/h4-9,14,16H,10-13,15H2,1-3H3,(H,27,34)(H3,28,29,30,31,32)/t16-/m0/s1
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
To measure inhibitory activity of FAK/PYK2 inhibitors, compounds were first prepare as a 1 mM stock in 100% DMSO and 3-fold serial dilution was perfo...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM245660
PNG
(US9428508, 115)
Show SMILES COCCNS(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(cc2OC)N2CCOCC2)nc2NCC(C)(C)c12
Show InChI InChI=1S/C28H37N7O5S/c1-28(2)18-29-25-24(28)26(31-21-7-5-6-8-23(21)41(36,37)30-11-14-38-3)34-27(33-25)32-20-10-9-19(17-22(20)39-4)35-12-15-40-16-13-35/h5-10,17,30H,11-16,18H2,1-4H3,(H3,29,31,32,33,34)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
To measure inhibitory activity of FAK/PYK2 inhibitors, compounds were first prepare as a 1 mM stock in 100% DMSO and 3-fold serial dilution was perfo...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM245665
PNG
(US9428508, 120)
Show SMILES COc1cc(ccc1Nc1nc2NCC(C)(C)c2c(Nc2ccccc2S(=O)(=O)NCCN(C)C)n1)N1CCOCC1
Show InChI InChI=1S/C29H40N8O4S/c1-29(2)19-30-26-25(29)27(32-22-8-6-7-9-24(22)42(38,39)31-12-13-36(3)4)35-28(34-26)33-21-11-10-20(18-23(21)40-5)37-14-16-41-17-15-37/h6-11,18,31H,12-17,19H2,1-5H3,(H3,30,32,33,34,35)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
To measure inhibitory activity of FAK/PYK2 inhibitors, compounds were first prepare as a 1 mM stock in 100% DMSO and 3-fold serial dilution was perfo...


Citation and Details
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM245678
PNG
(US9428508, 133)
Show SMILES CCN1c2ccc(Nc3nc4NCC(C)(C)c4c(Nc4ccccc4C(=O)NC)n3)c(OC)c2CCCC1=O
Show InChI InChI=1S/C29H35N7O3/c1-6-36-21-15-14-20(24(39-5)18(21)11-9-13-22(36)37)33-28-34-25-23(29(2,3)16-31-25)26(35-28)32-19-12-8-7-10-17(19)27(38)30-4/h7-8,10,12,14-15H,6,9,11,13,16H2,1-5H3,(H,30,38)(H3,31,32,33,34,35)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
To measure inhibitory activity of FAK/PYK2 inhibitors, compounds were first prepare as a 1 mM stock in 100% DMSO and 3-fold serial dilution was perfo...


Citation and Details
More data for this
Ligand-Target Pair
PTK2B protein tyrosine kinase 2 beta (PTK2B)


(Homo sapiens (Human))
BDBM245614
PNG
(US9428508, 69)
Show SMILES CC(C)NS(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(cc2)C(C)O)nc2NCCc12
Show InChI InChI=1S/C23H28N6O3S/c1-14(2)29-33(31,32)20-7-5-4-6-19(20)26-22-18-12-13-24-21(18)27-23(28-22)25-17-10-8-16(9-11-17)15(3)30/h4-11,14-15,29-30H,12-13H2,1-3H3,(H3,24,25,26,27,28)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
To measure inhibitory activity of FAK/PYK2 inhibitors, compounds were first prepare as a 1 mM stock in 100% DMSO and 3-fold serial dilution was perfo...


Citation and Details
More data for this
Ligand-Target Pair
PTK2B protein tyrosine kinase 2 beta (PTK2B)


(Homo sapiens (Human))
BDBM245623
PNG
(US9428508, 78)
Show SMILES CC(C)NS(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(cc2)C(=O)N2CCCC2)nc2NCCc12
Show InChI InChI=1S/C26H31N7O3S/c1-17(2)32-37(35,36)22-8-4-3-7-21(22)29-24-20-13-14-27-23(20)30-26(31-24)28-19-11-9-18(10-12-19)25(34)33-15-5-6-16-33/h3-4,7-12,17,32H,5-6,13-16H2,1-2H3,(H3,27,28,29,30,31)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
To measure inhibitory activity of FAK/PYK2 inhibitors, compounds were first prepare as a 1 mM stock in 100% DMSO and 3-fold serial dilution was perfo...


Citation and Details
More data for this
Ligand-Target Pair
PTK2B protein tyrosine kinase 2 beta (PTK2B)


(Homo sapiens (Human))
BDBM245650
PNG
(US9428508, 105)
Show SMILES COc1cc(ccc1Nc1nc2NCC(C)(C)c2c(Nc2ccccc2S(=O)(=O)NC(C)C)n1)N1CCOCC1
Show InChI InChI=1S/C28H37N7O4S/c1-18(2)34-40(36,37)23-9-7-6-8-21(23)30-26-24-25(29-17-28(24,3)4)32-27(33-26)31-20-11-10-19(16-22(20)38-5)35-12-14-39-15-13-35/h6-11,16,18,34H,12-15,17H2,1-5H3,(H3,29,30,31,32,33)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
To measure inhibitory activity of FAK/PYK2 inhibitors, compounds were first prepare as a 1 mM stock in 100% DMSO and 3-fold serial dilution was perfo...


Citation and Details
More data for this
Ligand-Target Pair
PTK2B protein tyrosine kinase 2 beta (PTK2B)


(Homo sapiens (Human))
BDBM245657
PNG
(US9428508, 112)
Show SMILES CCC(C)NS(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(cc2OC)N2CCOCC2)nc2NCC(C)(C)c12
Show InChI InChI=1S/C29H39N7O4S/c1-6-19(2)35-41(37,38)24-10-8-7-9-22(24)31-27-25-26(30-18-29(25,3)4)33-28(34-27)32-21-12-11-20(17-23(21)39-5)36-13-15-40-16-14-36/h7-12,17,19,35H,6,13-16,18H2,1-5H3,(H3,30,31,32,33,34)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
To measure inhibitory activity of FAK/PYK2 inhibitors, compounds were first prepare as a 1 mM stock in 100% DMSO and 3-fold serial dilution was perfo...


Citation and Details
More data for this
Ligand-Target Pair
PTK2B protein tyrosine kinase 2 beta (PTK2B)


(Homo sapiens (Human))
BDBM245673
PNG
(US9428508, 128)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2cccc3OCCOc23)nc2NCC(C)(C)c12
Show InChI InChI=1S/C24H26N6O3/c1-24(2)13-26-20-18(24)21(27-15-8-5-4-7-14(15)22(31)25-3)30-23(29-20)28-16-9-6-10-17-19(16)33-12-11-32-17/h4-10H,11-13H2,1-3H3,(H,25,31)(H3,26,27,28,29,30)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
To measure inhibitory activity of FAK/PYK2 inhibitors, compounds were first prepare as a 1 mM stock in 100% DMSO and 3-fold serial dilution was perfo...


Citation and Details
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%