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Patent code US9434693

Compile Data Set for Download or QSAR
Found 45 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
N-type calcium channel subunits alpha 1B (Cav2.2), Beta 3, and Alpha 2 Delta


(Homo sapiens (Human))
BDBM246344
PNG
(US9434693, 39)
Show SMILES COc1ccccc1-n1nc(OC2CC(C)(C)[S@+]([O-])C(C)(C)C2)cc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C25H29ClN2O3S/c1-24(2)15-19(16-25(3,4)32(24)29)31-23-14-21(17-10-12-18(26)13-11-17)28(27-23)20-8-6-7-9-22(20)30-5/h6-14,19H,15-16H2,1-5H3/t19?,32-
PDB

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UniChem
US Patent
n/an/a 1.5n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence...


Citation and Details
More data for this
Ligand-Target Pair
N-type calcium channel subunits alpha 1B (Cav2.2), Beta 3, and Alpha 2 Delta


(Homo sapiens (Human))
BDBM246342
PNG
(US9434693, 37)
Show SMILES COc1ccccc1-n1nc(OC2CC(C)(C)S(=O)(=O)C(C)(C)C2)cc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C25H29ClN2O4S/c1-24(2)15-19(16-25(3,4)33(24,29)30)32-23-14-21(17-10-12-18(26)13-11-17)28(27-23)20-8-6-7-9-22(20)31-5/h6-14,19H,15-16H2,1-5H3
PDB

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US Patent
n/an/a 1.90n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence...


Citation and Details
More data for this
Ligand-Target Pair
N-type calcium channel subunits alpha 1B (Cav2.2), Beta 3, and Alpha 2 Delta


(Homo sapiens (Human))
BDBM246350
PNG
(US9434693, 45)
Show SMILES COc1ccccc1-n1nc(OC2CC(C)(C)S(=O)(=O)C(C)(C)C2)cc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C26H29N3O4S/c1-25(2)15-20(16-26(3,4)34(25,30)31)33-24-14-22(19-12-10-18(17-27)11-13-19)29(28-24)21-8-6-7-9-23(21)32-5/h6-14,20H,15-16H2,1-5H3
PDB

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UniChem
US Patent
n/an/a 2.40n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence...


Citation and Details
More data for this
Ligand-Target Pair
N-type calcium channel subunits alpha 1B (Cav2.2), Beta 3, and Alpha 2 Delta


(Homo sapiens (Human))
BDBM246343
PNG
(US9434693, 38)
Show SMILES COc1ccccc1-n1nc(OC2CC(C)(C)[S@+]([O-])C(C)(C)C2)cc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C25H29ClN2O3S/c1-24(2)15-19(16-25(3,4)32(24)29)31-23-14-21(17-10-12-18(26)13-11-17)28(27-23)20-8-6-7-9-22(20)30-5/h6-14,19H,15-16H2,1-5H3/t19?,32-
PDB

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US Patent
n/an/a 2.70n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence...


Citation and Details
More data for this
Ligand-Target Pair
N-type calcium channel subunits alpha 1B (Cav2.2), Beta 3, and Alpha 2 Delta


(Homo sapiens (Human))
BDBM246338
PNG
(US9434693, 33)
Show SMILES COc1ccc(cc1)-c1cc(OC2CC(C)(C)S(=O)(=O)C(C)(C)C2)nn1-c1ccccc1OC
Show InChI InChI=1S/C26H32N2O5S/c1-25(2)16-20(17-26(3,4)34(25,29)30)33-24-15-22(18-11-13-19(31-5)14-12-18)28(27-24)21-9-7-8-10-23(21)32-6/h7-15,20H,16-17H2,1-6H3
PDB

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US Patent
n/an/a 3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence...


Citation and Details
More data for this
Ligand-Target Pair
N-type calcium channel subunits alpha 1B (Cav2.2), Beta 3, and Alpha 2 Delta


(Homo sapiens (Human))
BDBM246345
PNG
(US9434693, 40)
Show SMILES COc1ccccc1-n1nc(OCC2C(C)(C)OC2(C)C)cc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C24H27ClN2O3/c1-23(2)21(24(3,4)30-23)15-29-22-14-19(16-10-12-17(25)13-11-16)27(26-22)18-8-6-7-9-20(18)28-5/h6-14,21H,15H2,1-5H3
PDB

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US Patent
n/an/a 3.10n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence...


Citation and Details
More data for this
Ligand-Target Pair
N-type calcium channel subunits alpha 1B (Cav2.2), Beta 3, and Alpha 2 Delta


(Homo sapiens (Human))
BDBM246339
PNG
(US9434693, 34)
Show SMILES COc1ccc(cc1)-c1cc(OC2CC(C)(C)[S@+]([O-])C(C)(C)C2)nn1-c1ccccc1OC
Show InChI InChI=1S/C26H32N2O4S/c1-25(2)16-20(17-26(3,4)33(25)29)32-24-15-22(18-11-13-19(30-5)14-12-18)28(27-24)21-9-7-8-10-23(21)31-6/h7-15,20H,16-17H2,1-6H3/t20?,33-
PDB

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US Patent
n/an/a 4.5n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence...


Citation and Details
More data for this
Ligand-Target Pair
N-type calcium channel subunits alpha 1B (Cav2.2), Beta 3, and Alpha 2 Delta


(Homo sapiens (Human))
BDBM246341
PNG
(US9434693, 36)
Show SMILES COc1ccccc1-n1nc(OC2CC(C)(C)SC(C)(C)C2)cc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C25H29ClN2O2S/c1-24(2)15-19(16-25(3,4)31-24)30-23-14-21(17-10-12-18(26)13-11-17)28(27-23)20-8-6-7-9-22(20)29-5/h6-14,19H,15-16H2,1-5H3
PDB

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US Patent
n/an/a 5.90n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence...


Citation and Details
More data for this
Ligand-Target Pair
N-type calcium channel subunits alpha 1B (Cav2.2), Beta 3, and Alpha 2 Delta


(Homo sapiens (Human))
BDBM246337
PNG
(US9434693, 32)
Show SMILES COc1ccc(cc1)-c1cc(OC2CC(C)(C)SC(C)(C)C2)nn1-c1ccccc1OC
Show InChI InChI=1S/C26H32N2O3S/c1-25(2)16-20(17-26(3,4)32-25)31-24-15-22(18-11-13-19(29-5)14-12-18)28(27-24)21-9-7-8-10-23(21)30-6/h7-15,20H,16-17H2,1-6H3
PDB

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US Patent
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Janssen Pharmaceutica NV

US Patent


Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence...


Citation and Details
More data for this
Ligand-Target Pair
N-type calcium channel subunits alpha 1B (Cav2.2), Beta 3, and Alpha 2 Delta


(Homo sapiens (Human))
BDBM246333
PNG
(US9434693, 28)
Show SMILES CC(C)Oc1ccccc1-n1nc(OC2CCN(CC2)S(=O)(=O)C(C)C)cc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C26H32ClN3O4S/c1-18(2)33-25-8-6-5-7-23(25)30-24(20-9-11-21(27)12-10-20)17-26(28-30)34-22-13-15-29(16-14-22)35(31,32)19(3)4/h5-12,17-19,22H,13-16H2,1-4H3
PDB

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US Patent
n/an/a 7n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence...


Citation and Details
More data for this
Ligand-Target Pair
N-type calcium channel subunits alpha 1B (Cav2.2), Beta 3, and Alpha 2 Delta


(Homo sapiens (Human))
BDBM246348
PNG
(US9434693, 43)
Show SMILES COc1ccccc1-n1nc(OC2CC(C)(C)OC(C)(C)C2)cc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C26H29N3O3/c1-25(2)15-20(16-26(3,4)32-25)31-24-14-22(19-12-10-18(17-27)11-13-19)29(28-24)21-8-6-7-9-23(21)30-5/h6-14,20H,15-16H2,1-5H3
PDB

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UniChem
US Patent
n/an/a 7.20n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence...


Citation and Details
More data for this
Ligand-Target Pair
N-type calcium channel subunits alpha 1B (Cav2.2), Beta 3, and Alpha 2 Delta


(Homo sapiens (Human))
BDBM246340
PNG
(US9434693, 35)
Show SMILES COc1ccc(cc1)-c1cc(OC2CC(C)(C)[S@+]([O-])C(C)(C)C2)nn1-c1ccccc1OC
Show InChI InChI=1S/C26H32N2O4S/c1-25(2)16-20(17-26(3,4)33(25)29)32-24-15-22(18-11-13-19(30-5)14-12-18)28(27-24)21-9-7-8-10-23(21)31-6/h7-15,20H,16-17H2,1-6H3/t20?,33-
PDB

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US Patent
n/an/a 7.60n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence...


Citation and Details
More data for this
Ligand-Target Pair
N-type calcium channel subunits alpha 1B (Cav2.2), Beta 3, and Alpha 2 Delta


(Homo sapiens (Human))
BDBM246329
PNG
(US9434693, 23)
Show SMILES COc1ccccc1-n1nc(OC2CC(C)(C)OC(C)(C)C2)cc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C25H29ClN2O3/c1-24(2)15-19(16-25(3,4)31-24)30-23-14-21(17-10-12-18(26)13-11-17)28(27-23)20-8-6-7-9-22(20)29-5/h6-14,19H,15-16H2,1-5H3
PDB

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US Patent
n/an/a 7.60n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence...


Citation and Details
More data for this
Ligand-Target Pair
N-type calcium channel subunits alpha 1B (Cav2.2), Beta 3, and Alpha 2 Delta


(Homo sapiens (Human))
BDBM246335
PNG
(US9434693, 30)
Show SMILES COc1ccccc1-n1nc(OC2CN(C2)S(=O)(=O)c2c(C)noc2C)cc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C24H23ClN4O5S/c1-15-24(16(2)34-27-15)35(30,31)28-13-19(14-28)33-23-12-21(17-8-10-18(25)11-9-17)29(26-23)20-6-4-5-7-22(20)32-3/h4-12,19H,13-14H2,1-3H3
PDB

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US Patent
n/an/a 8n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence...


Citation and Details
More data for this
Ligand-Target Pair
N-type calcium channel subunits alpha 1B (Cav2.2), Beta 3, and Alpha 2 Delta


(Homo sapiens (Human))
BDBM246321
PNG
(US9434693, 15)
Show SMILES COc1ccccc1-n1nc(OC2CCN(CC2)S(=O)(=O)C2CC2)cc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C24H26ClN3O4S/c1-31-23-5-3-2-4-21(23)28-22(17-6-8-18(25)9-7-17)16-24(26-28)32-19-12-14-27(15-13-19)33(29,30)20-10-11-20/h2-9,16,19-20H,10-15H2,1H3
PDB

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US Patent
n/an/a 9n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence...


Citation and Details
More data for this
Ligand-Target Pair
N-type calcium channel subunits alpha 1B (Cav2.2), Beta 3, and Alpha 2 Delta


(Homo sapiens (Human))
BDBM246336
PNG
(US9434693, 31)
Show SMILES COc1ccc(cc1)-c1cc(OC2CC(C)(C)OC(C)(C)C2)nn1-c1ccccc1OC
Show InChI InChI=1S/C26H32N2O4/c1-25(2)16-20(17-26(3,4)32-25)31-24-15-22(18-11-13-19(29-5)14-12-18)28(27-24)21-9-7-8-10-23(21)30-6/h7-15,20H,16-17H2,1-6H3
PDB

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US Patent
n/an/a 9.40n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence...


Citation and Details
More data for this
Ligand-Target Pair
N-type calcium channel subunits alpha 1B (Cav2.2), Beta 3, and Alpha 2 Delta


(Homo sapiens (Human))
BDBM246346
PNG
(US9434693, 41)
Show SMILES COc1ccccc1-n1nc(OC2CC(C)(C)C(=O)C(C)(C)C2)cc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C26H29ClN2O3/c1-25(2)15-19(16-26(3,4)24(25)30)32-23-14-21(17-10-12-18(27)13-11-17)29(28-23)20-8-6-7-9-22(20)31-5/h6-14,19H,15-16H2,1-5H3
PDB

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US Patent
n/an/a 9.70n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence...


Citation and Details
More data for this
Ligand-Target Pair
N-type calcium channel subunits alpha 1B (Cav2.2), Beta 3, and Alpha 2 Delta


(Homo sapiens (Human))
BDBM246319
PNG
(US9434693, 13)
Show SMILES COc1ccccc1-n1nc(O[C@@H]2CC[C@@H](CC2)NC(=O)C(F)(F)F)cc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C24H23ClF3N3O3/c1-33-21-5-3-2-4-19(21)31-20(15-6-8-16(25)9-7-15)14-22(30-31)34-18-12-10-17(11-13-18)29-23(32)24(26,27)28/h2-9,14,17-18H,10-13H2,1H3,(H,29,32)/t17-,18+
PDB

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n/an/a 11n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence...


Citation and Details
More data for this
Ligand-Target Pair
N-type calcium channel subunits alpha 1B (Cav2.2), Beta 3, and Alpha 2 Delta


(Homo sapiens (Human))
BDBM246349
PNG
(US9434693, 44)
Show SMILES COc1ccccc1-n1nc(OC2CC(C)(C)SC(C)(C)C2)cc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C26H29N3O2S/c1-25(2)15-20(16-26(3,4)32-25)31-24-14-22(19-12-10-18(17-27)11-13-19)29(28-24)21-8-6-7-9-23(21)30-5/h6-14,20H,15-16H2,1-5H3
PDB

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n/an/a 12n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence...


Citation and Details
More data for this
Ligand-Target Pair
N-type calcium channel subunits alpha 1B (Cav2.2), Beta 3, and Alpha 2 Delta


(Homo sapiens (Human))
BDBM246310
PNG
(US9434693, 4)
Show SMILES COc1ccccc1-n1nc(OC2CCN(CC2)C(=O)N(C)C)cc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C24H27ClN4O3/c1-27(2)24(30)28-14-12-19(13-15-28)32-23-16-21(17-8-10-18(25)11-9-17)29(26-23)20-6-4-5-7-22(20)31-3/h4-11,16,19H,12-15H2,1-3H3
PDB

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UniChem
US Patent
n/an/a 14n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence...


Citation and Details
More data for this
Ligand-Target Pair
N-type calcium channel subunits alpha 1B (Cav2.2), Beta 3, and Alpha 2 Delta


(Homo sapiens (Human))
BDBM246351
PNG
(US9434693, 46)
Show SMILES COc1ccccc1-n1nc(OC2CC(C)(C)[S@+]([O-])C(C)(C)C2)cc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C26H29N3O3S/c1-25(2)15-20(16-26(3,4)33(25)30)32-24-14-22(19-12-10-18(17-27)11-13-19)29(28-24)21-8-6-7-9-23(21)31-5/h6-14,20H,15-16H2,1-5H3/t20?,33-
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 14n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence...


Citation and Details
More data for this
Ligand-Target Pair
N-type calcium channel subunits alpha 1B (Cav2.2), Beta 3, and Alpha 2 Delta


(Homo sapiens (Human))
BDBM246334
PNG
(US9434693, 29)
Show SMILES CON(C)C(=O)N1CC(C1)Oc1cc(-c2ccc(Cl)cc2)n(n1)-c1ccccc1OC
Show InChI InChI=1S/C22H23ClN4O4/c1-25(30-3)22(28)26-13-17(14-26)31-21-12-19(15-8-10-16(23)11-9-15)27(24-21)18-6-4-5-7-20(18)29-2/h4-12,17H,13-14H2,1-3H3
PDB

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PC sid
UniChem
US Patent
n/an/a 14n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence...


Citation and Details
More data for this
Ligand-Target Pair
N-type calcium channel subunits alpha 1B (Cav2.2), Beta 3, and Alpha 2 Delta


(Homo sapiens (Human))
BDBM246311
PNG
(US9434693, 5)
Show SMILES COc1ccccc1-n1nc(OC2CCN(CC2)S(C)(=O)=O)cc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C22H24ClN3O4S/c1-29-21-6-4-3-5-19(21)26-20(16-7-9-17(23)10-8-16)15-22(24-26)30-18-11-13-25(14-12-18)31(2,27)28/h3-10,15,18H,11-14H2,1-2H3
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Janssen Pharmaceutica NV

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Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence...


Citation and Details
More data for this
Ligand-Target Pair
N-type calcium channel subunits alpha 1B (Cav2.2), Beta 3, and Alpha 2 Delta


(Homo sapiens (Human))
BDBM246312
PNG
(US9434693, 6)
Show SMILES COc1ccccc1-n1nc(OC2CCOCC2)cc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H21ClN2O3/c1-25-20-5-3-2-4-18(20)24-19(15-6-8-16(22)9-7-15)14-21(23-24)27-17-10-12-26-13-11-17/h2-9,14,17H,10-13H2,1H3
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Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence...


Citation and Details
More data for this
Ligand-Target Pair
N-type calcium channel subunits alpha 1B (Cav2.2), Beta 3, and Alpha 2 Delta


(Homo sapiens (Human))
BDBM246326
PNG
(US9434693, 20)
Show SMILES CC(C)Oc1ccccc1-n1nc(OC2CCN(CC2)S(C)(=O)=O)cc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C24H28ClN3O4S/c1-17(2)31-23-7-5-4-6-21(23)28-22(18-8-10-19(25)11-9-18)16-24(26-28)32-20-12-14-27(15-13-20)33(3,29)30/h4-11,16-17,20H,12-15H2,1-3H3
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Janssen Pharmaceutica NV

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Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence...


Citation and Details
More data for this
Ligand-Target Pair
N-type calcium channel subunits alpha 1B (Cav2.2), Beta 3, and Alpha 2 Delta


(Homo sapiens (Human))
BDBM246320
PNG
(US9434693, 14)
Show SMILES COc1ccccc1-n1nc(OC2CCN(CC2)S(=O)(=O)C(F)(F)F)cc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C22H21ClF3N3O4S/c1-32-20-5-3-2-4-18(20)29-19(15-6-8-16(23)9-7-15)14-21(27-29)33-17-10-12-28(13-11-17)34(30,31)22(24,25)26/h2-9,14,17H,10-13H2,1H3
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Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence...


Citation and Details
More data for this
Ligand-Target Pair
N-type calcium channel subunits alpha 1B (Cav2.2), Beta 3, and Alpha 2 Delta


(Homo sapiens (Human))
BDBM246309
PNG
(US9434693, 3)
Show SMILES COc1ccccc1-n1nc(OC2CCN(CC2)C(C)=O)cc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H24ClN3O3/c1-16(28)26-13-11-19(12-14-26)30-23-15-21(17-7-9-18(24)10-8-17)27(25-23)20-5-3-4-6-22(20)29-2/h3-10,15,19H,11-14H2,1-2H3
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Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence...


Citation and Details
More data for this
Ligand-Target Pair
N-type calcium channel subunits alpha 1B (Cav2.2), Beta 3, and Alpha 2 Delta


(Homo sapiens (Human))
BDBM246313
PNG
(US9434693, 7)
Show SMILES COc1ccccc1-n1nc(OC2CCSCC2)cc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H21ClN2O2S/c1-25-20-5-3-2-4-18(20)24-19(15-6-8-16(22)9-7-15)14-21(23-24)26-17-10-12-27-13-11-17/h2-9,14,17H,10-13H2,1H3
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Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence...


Citation and Details
More data for this
Ligand-Target Pair
N-type calcium channel subunits alpha 1B (Cav2.2), Beta 3, and Alpha 2 Delta


(Homo sapiens (Human))
BDBM246308
PNG
(US9434693, 2)
Show SMILES COc1ccccc1-n1nc(OC2CCC(=O)CC2)cc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C22H21ClN2O3/c1-27-21-5-3-2-4-19(21)25-20(15-6-8-16(23)9-7-15)14-22(24-25)28-18-12-10-17(26)11-13-18/h2-9,14,18H,10-13H2,1H3
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Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence...


Citation and Details
More data for this
Ligand-Target Pair
N-type calcium channel subunits alpha 1B (Cav2.2), Beta 3, and Alpha 2 Delta


(Homo sapiens (Human))
BDBM246316
PNG
(US9434693, 10)
Show SMILES COc1ccccc1-n1nc(OC2CCS(=O)(=O)CC2)cc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H21ClN2O4S/c1-27-20-5-3-2-4-18(20)24-19(15-6-8-16(22)9-7-15)14-21(23-24)28-17-10-12-29(25,26)13-11-17/h2-9,14,17H,10-13H2,1H3
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Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence...


Citation and Details
More data for this
Ligand-Target Pair
N-type calcium channel subunits alpha 1B (Cav2.2), Beta 3, and Alpha 2 Delta


(Homo sapiens (Human))
BDBM246307
PNG
(US9434693, 1)
Show SMILES COc1ccccc1-n1nc(OC2CCN(CC2)C(=O)OC(C)(C)C)cc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C26H30ClN3O4/c1-26(2,3)34-25(31)29-15-13-20(14-16-29)33-24-17-22(18-9-11-19(27)12-10-18)30(28-24)21-7-5-6-8-23(21)32-4/h5-12,17,20H,13-16H2,1-4H3
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Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence...


Citation and Details
More data for this
Ligand-Target Pair
N-type calcium channel subunits alpha 1B (Cav2.2), Beta 3, and Alpha 2 Delta


(Homo sapiens (Human))
BDBM246314
PNG
(US9434693, 8)
Show SMILES COc1ccccc1-n1nc(OC2CCN(CC(F)(F)F)CC2)cc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H23ClF3N3O2/c1-31-21-5-3-2-4-19(21)30-20(16-6-8-17(24)9-7-16)14-22(28-30)32-18-10-12-29(13-11-18)15-23(25,26)27/h2-9,14,18H,10-13,15H2,1H3
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Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence...


Citation and Details
More data for this
Ligand-Target Pair
N-type calcium channel subunits alpha 1B (Cav2.2), Beta 3, and Alpha 2 Delta


(Homo sapiens (Human))
BDBM246331
PNG
(US9434693, 26)
Show SMILES COc1ccccc1-n1nc(OC2CN(C2)S(C)(=O)=O)cc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C20H20ClN3O4S/c1-27-19-6-4-3-5-17(19)24-18(14-7-9-15(21)10-8-14)11-20(22-24)28-16-12-23(13-16)29(2,25)26/h3-11,16H,12-13H2,1-2H3
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Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence...


Citation and Details
More data for this
Ligand-Target Pair
N-type calcium channel subunits alpha 1B (Cav2.2), Beta 3, and Alpha 2 Delta


(Homo sapiens (Human))
BDBM246315
PNG
(US9434693, 9)
Show SMILES COc1ccccc1-n1nc(OC2CCN(CC2)C(=O)C(F)(F)F)cc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H21ClF3N3O3/c1-32-20-5-3-2-4-18(20)30-19(15-6-8-16(24)9-7-15)14-21(28-30)33-17-10-12-29(13-11-17)22(31)23(25,26)27/h2-9,14,17H,10-13H2,1H3
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Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence...


Citation and Details
More data for this
Ligand-Target Pair
N-type calcium channel subunits alpha 1B (Cav2.2), Beta 3, and Alpha 2 Delta


(Homo sapiens (Human))
BDBM246330
PNG
(US9434693, 25)
Show SMILES COc1ccccc1-n1nc(OC2CN(C2)S(=O)(=O)C(C)C)cc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C22H24ClN3O4S/c1-15(2)31(27,28)25-13-18(14-25)30-22-12-20(16-8-10-17(23)11-9-16)26(24-22)19-6-4-5-7-21(19)29-3/h4-12,15,18H,13-14H2,1-3H3
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Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence...


Citation and Details
More data for this
Ligand-Target Pair
N-type calcium channel subunits alpha 1B (Cav2.2), Beta 3, and Alpha 2 Delta


(Homo sapiens (Human))
BDBM246327
PNG
(US9434693, 21)
Show SMILES COc1ccccc1-n1nc(OC2CCN(CC2)S(=O)(=O)C(C)C)cc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C24H28ClN3O4S/c1-17(2)33(29,30)27-14-12-20(13-15-27)32-24-16-22(18-8-10-19(25)11-9-18)28(26-24)21-6-4-5-7-23(21)31-3/h4-11,16-17,20H,12-15H2,1-3H3
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Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence...


Citation and Details
More data for this
Ligand-Target Pair
N-type calcium channel subunits alpha 1B (Cav2.2), Beta 3, and Alpha 2 Delta


(Homo sapiens (Human))
BDBM246347
PNG
(US9434693, 42)
Show SMILES COc1ccccc1-n1nc(OC2CC(C)(C)C(O)C(C)(C)C2)cc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C26H31ClN2O3/c1-25(2)15-19(16-26(3,4)24(25)30)32-23-14-21(17-10-12-18(27)13-11-17)29(28-23)20-8-6-7-9-22(20)31-5/h6-14,19,24,30H,15-16H2,1-5H3
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Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence...


Citation and Details
More data for this
Ligand-Target Pair
N-type calcium channel subunits alpha 1B (Cav2.2), Beta 3, and Alpha 2 Delta


(Homo sapiens (Human))
BDBM246322
PNG
(US9434693, 16)
Show SMILES COc1ccccc1-n1nc(OC2CCC(F)(F)CC2)cc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C22H21ClF2N2O2/c1-28-20-5-3-2-4-18(20)27-19(15-6-8-16(23)9-7-15)14-21(26-27)29-17-10-12-22(24,25)13-11-17/h2-9,14,17H,10-13H2,1H3
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Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence...


Citation and Details
More data for this
Ligand-Target Pair
N-type calcium channel subunits alpha 1B (Cav2.2), Beta 3, and Alpha 2 Delta


(Homo sapiens (Human))
BDBM246324
PNG
(US9434693, 18)
Show SMILES CCc1ccccc1-n1nc(OC2CCN(CC2)C(=O)OC(C)(C)C)cc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C27H32ClN3O3/c1-5-19-8-6-7-9-23(19)31-24(20-10-12-21(28)13-11-20)18-25(29-31)33-22-14-16-30(17-15-22)26(32)34-27(2,3)4/h6-13,18,22H,5,14-17H2,1-4H3
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Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence...


Citation and Details
More data for this
Ligand-Target Pair
N-type calcium channel subunits alpha 1B (Cav2.2), Beta 3, and Alpha 2 Delta


(Homo sapiens (Human))
BDBM246317
PNG
(US9434693, 11)
Show SMILES COc1ccccc1-n1nc(O[C@@H]2CC[C@@H](CC2)NC(=O)OC(C)(C)C)cc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C27H32ClN3O4/c1-27(2,3)35-26(32)29-20-13-15-21(16-14-20)34-25-17-23(18-9-11-19(28)12-10-18)31(30-25)22-7-5-6-8-24(22)33-4/h5-12,17,20-21H,13-16H2,1-4H3,(H,29,32)/t20-,21+
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Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence...


Citation and Details
More data for this
Ligand-Target Pair
N-type calcium channel subunits alpha 1B (Cav2.2), Beta 3, and Alpha 2 Delta


(Homo sapiens (Human))
BDBM246328
PNG
(US9434693, 22)
Show SMILES COc1ccccc1-n1nc(OC2CN(C2)C(=O)OC(C)(C)C)cc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C24H26ClN3O4/c1-24(2,3)32-23(29)27-14-18(15-27)31-22-13-20(16-9-11-17(25)12-10-16)28(26-22)19-7-5-6-8-21(19)30-4/h5-13,18H,14-15H2,1-4H3
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Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence...


Citation and Details
More data for this
Ligand-Target Pair
N-type calcium channel subunits alpha 1B (Cav2.2), Beta 3, and Alpha 2 Delta


(Homo sapiens (Human))
BDBM246323
PNG
(US9434693, 17)
Show SMILES CCc1ccccc1-n1nc(OC2CCC3(CC2)OCCO3)cc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C25H27ClN2O3/c1-2-18-5-3-4-6-22(18)28-23(19-7-9-20(26)10-8-19)17-24(27-28)31-21-11-13-25(14-12-21)29-15-16-30-25/h3-10,17,21H,2,11-16H2,1H3
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Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence...


Citation and Details
More data for this
Ligand-Target Pair
N-type calcium channel subunits alpha 1B (Cav2.2), Beta 3, and Alpha 2 Delta


(Homo sapiens (Human))
BDBM246332
PNG
(US9434693, 27)
Show SMILES COc1ccccc1-n1nc(OC2CN(C2)C(=O)c2ccccc2)cc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C26H22ClN3O3/c1-32-24-10-6-5-9-22(24)30-23(18-11-13-20(27)14-12-18)15-25(28-30)33-21-16-29(17-21)26(31)19-7-3-2-4-8-19/h2-15,21H,16-17H2,1H3
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Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence...


Citation and Details
More data for this
Ligand-Target Pair
N-type calcium channel subunits alpha 1B (Cav2.2), Beta 3, and Alpha 2 Delta


(Homo sapiens (Human))
BDBM246325
PNG
(US9434693, 19)
Show SMILES CCc1ccccc1-n1nc(OC2CCN(CC2)S(C)(=O)=O)cc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H26ClN3O3S/c1-3-17-6-4-5-7-21(17)27-22(18-8-10-19(24)11-9-18)16-23(25-27)30-20-12-14-26(15-13-20)31(2,28)29/h4-11,16,20H,3,12-15H2,1-2H3
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Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence...


Citation and Details
More data for this
Ligand-Target Pair
N-type calcium channel subunits alpha 1B (Cav2.2), Beta 3, and Alpha 2 Delta


(Homo sapiens (Human))
BDBM246318
PNG
(US9434693, 12)
Show SMILES COc1ccccc1-n1nc(O[C@@H]2CC[C@H](N)CC2)cc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C22H24ClN3O2/c1-27-21-5-3-2-4-19(21)26-20(15-6-8-16(23)9-7-15)14-22(25-26)28-18-12-10-17(24)11-13-18/h2-9,14,17-18H,10-13,24H2,1H3/t17-,18+
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US Patent


Assay Description
Calcium mobilization responses to KCl depolarization were evaluated by measuring the intensity of calcium-mediated fluorescent signal in the presence...


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