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Patent code US9434697

Compile Data Set for Download or QSAR
Found 144 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249396
PNG
(US9434697, 108)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H34Cl2N8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)
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n/an/a<0.200n/an/an/an/an/an/a



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), or FGFR4 (12 nM) was prepared as a mixture with substrate KKKSPGEYVNIEFG (SEQ ID NO:1) (20 μM, FGFR1 substrate); Pol...


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More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249427
PNG
(US9434697, 147)
Show SMILES COCc1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C25H26Cl2N6O5/c1-6-21(34)31-16-9-14(12-36-3)7-8-15(16)30-19-11-20(29-13-28-19)33(2)25(35)32-24-22(26)17(37-4)10-18(38-5)23(24)27/h6-11,13H,1,12H2,2-5H3,(H,31,34)(H,32,35)(H,28,29,30)
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n/an/a<1n/an/an/an/an/an/a



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249442
PNG
(US9434697, 163)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(CCN(C)C)cc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C27H31Cl2N7O4/c1-7-23(37)33-18-12-16(10-11-35(2)3)8-9-17(18)32-21-14-22(31-15-30-21)36(4)27(38)34-26-24(28)19(39-5)13-20(40-6)25(26)29/h7-9,12-15H,1,10-11H2,2-6H3,(H,33,37)(H,34,38)(H,30,31,32)
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n/an/a<1n/an/an/an/an/an/a



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249399
PNG
(US9434697, 112)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)C3CCN(C)CC3)ncn2)c1Cl
Show InChI InChI=1S/C29H33Cl2N7O4/c1-6-25(39)35-20-13-18(17-9-11-37(2)12-10-17)7-8-19(20)34-23-15-24(33-16-32-23)38(3)29(40)36-28-26(30)21(41-4)14-22(42-5)27(28)31/h6-8,13-17H,1,9-12H2,2-5H3,(H,35,39)(H,36,40)(H,32,33,34)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249407
PNG
(US9434697, 124)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3C[C@H](C)N[C@H](C)C3)ncn2)c1Cl
Show InChI InChI=1S/C29H34Cl2N8O4/c1-7-25(40)36-20-10-18(39-13-16(2)34-17(3)14-39)8-9-19(20)35-23-12-24(33-15-32-23)38(4)29(41)37-28-26(30)21(42-5)11-22(43-6)27(28)31/h7-12,15-17,34H,1,13-14H2,2-6H3,(H,36,40)(H,37,41)(H,32,33,35)/t16-,17+
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249414
PNG
(US9434697, 131)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(Cc2ccccn2)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C28H25Cl2N7O4/c1-4-24(38)35-19-11-6-5-10-18(19)34-22-14-23(33-16-32-22)37(15-17-9-7-8-12-31-17)28(39)36-27-25(29)20(40-2)13-21(41-3)26(27)30/h4-14,16H,1,15H2,2-3H3,(H,35,38)(H,36,39)(H,32,33,34)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249436
PNG
(US9434697, 157)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCNCC3)ncn2)c1Cl
Show InChI InChI=1S/C27H30Cl2N8O4/c1-5-23(38)34-18-12-16(37-10-8-30-9-11-37)6-7-17(18)33-21-14-22(32-15-31-21)36(2)27(39)35-26-24(28)19(40-3)13-20(41-4)25(26)29/h5-7,12-15,30H,1,8-11H2,2-4H3,(H,34,38)(H,35,39)(H,31,32,33)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249398
PNG
(US9434697, 111)
Show SMILES CCN1CCC(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C30H35Cl2N7O4/c1-6-26(40)36-21-14-19(18-10-12-39(7-2)13-11-18)8-9-20(21)35-24-16-25(34-17-33-24)38(3)30(41)37-29-27(31)22(42-4)15-23(43-5)28(29)32/h6,8-9,14-18H,1,7,10-13H2,2-5H3,(H,36,40)(H,37,41)(H,33,34,35)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249405
PNG
(US9434697, 122)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)C3CCNCC3)ncn2)c1Cl
Show InChI InChI=1S/C28H31Cl2N7O4/c1-5-24(38)35-19-12-17(16-8-10-31-11-9-16)6-7-18(19)34-22-14-23(33-15-32-22)37(2)28(39)36-27-25(29)20(40-3)13-21(41-4)26(27)30/h5-7,12-16,31H,1,8-11H2,2-4H3,(H,35,38)(H,36,39)(H,32,33,34)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249419
PNG
(US9434697, 137)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3cc(CCN(C)C)ccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C27H31Cl2N7O4/c1-7-23(37)33-17-9-8-16(10-11-35(2)3)12-18(17)32-21-14-22(31-15-30-21)36(4)27(38)34-26-24(28)19(39-5)13-20(40-6)25(26)29/h7-9,12-15H,1,10-11H2,2-6H3,(H,33,37)(H,34,38)(H,30,31,32)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249431
PNG
(US9434697, 151)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCN(CC3)C(C)C)ncn2)c1Cl
Show InChI InChI=1S/C30H36Cl2N8O4/c1-7-26(41)36-21-14-19(40-12-10-39(11-13-40)18(2)3)8-9-20(21)35-24-16-25(34-17-33-24)38(4)30(42)37-29-27(31)22(43-5)15-23(44-6)28(29)32/h7-9,14-18H,1,10-13H2,2-6H3,(H,36,41)(H,37,42)(H,33,34,35)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249433
PNG
(US9434697, 154)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCN(CC3)C(C)=O)ncn2)c1Cl
Show InChI InChI=1S/C29H32Cl2N8O5/c1-6-25(41)35-20-13-18(39-11-9-38(10-12-39)17(2)40)7-8-19(20)34-23-15-24(33-16-32-23)37(3)29(42)36-28-26(30)21(43-4)14-22(44-5)27(28)31/h6-8,13-16H,1,9-12H2,2-5H3,(H,35,41)(H,36,42)(H,32,33,34)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249440
PNG
(US9434697, 161)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCN(CCN)CC3)ncn2)c1Cl
Show InChI InChI=1S/C29H35Cl2N9O4/c1-5-25(41)36-20-14-18(40-12-10-39(9-8-32)11-13-40)6-7-19(20)35-23-16-24(34-17-33-23)38(2)29(42)37-28-26(30)21(43-3)15-22(44-4)27(28)31/h5-7,14-17H,1,8-13,32H2,2-4H3,(H,36,41)(H,37,42)(H,33,34,35)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249445
PNG
(US9434697, 166)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3c(NC(=O)C=C)cccc3OC)ncn2)c1Cl
Show InChI InChI=1S/C24H24Cl2N6O5/c1-6-19(33)29-13-8-7-9-14(35-3)22(13)30-17-11-18(28-12-27-17)32(2)24(34)31-23-20(25)15(36-4)10-16(37-5)21(23)26/h6-12H,1H2,2-5H3,(H,29,33)(H,31,34)(H,27,28,30)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249396
PNG
(US9434697, 108)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H34Cl2N8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249400
PNG
(US9434697, 113)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(CN(C)C)cc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C26H29Cl2N7O4/c1-7-22(36)32-17-10-15(13-34(2)3)8-9-16(17)31-20-12-21(30-14-29-20)35(4)26(37)33-25-23(27)18(38-5)11-19(39-6)24(25)28/h7-12,14H,1,13H2,2-6H3,(H,32,36)(H,33,37)(H,29,30,31)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249415
PNG
(US9434697, 132)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(Cc2ccncc2)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C28H25Cl2N7O4/c1-4-24(38)35-19-8-6-5-7-18(19)34-22-14-23(33-16-32-22)37(15-17-9-11-31-12-10-17)28(39)36-27-25(29)20(40-2)13-21(41-3)26(27)30/h4-14,16H,1,15H2,2-3H3,(H,35,38)(H,36,39)(H,32,33,34)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249434
PNG
(US9434697, 155)
Show SMILES COC(C)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C26H28Cl2N6O5/c1-7-22(35)32-17-10-15(14(2)37-4)8-9-16(17)31-20-12-21(30-13-29-20)34(3)26(36)33-25-23(27)18(38-5)11-19(39-6)24(25)28/h7-14H,1H2,2-6H3,(H,32,35)(H,33,36)(H,29,30,31)
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n/an/a<1n/an/an/an/an/an/a



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249444
PNG
(US9434697, 165)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3c(C)cccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C24H24Cl2N6O4/c1-6-19(33)29-14-9-7-8-13(2)22(14)30-17-11-18(28-12-27-17)32(3)24(34)31-23-20(25)15(35-4)10-16(36-5)21(23)26/h6-12H,1H2,2-5H3,(H,29,33)(H,31,34)(H,27,28,30)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249447
PNG
(US9434697, 168)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCN(CCO)CC3)ncn2)c1Cl
Show InChI InChI=1S/C29H34Cl2N8O5/c1-5-25(41)35-20-14-18(39-10-8-38(9-11-39)12-13-40)6-7-19(20)34-23-16-24(33-17-32-23)37(2)29(42)36-28-26(30)21(43-3)15-22(44-4)27(28)31/h5-7,14-17,40H,1,8-13H2,2-4H3,(H,35,41)(H,36,42)(H,32,33,34)
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249395
PNG
(US9434697, 107)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(Cc2cccnc2)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C28H25Cl2N7O4/c1-4-24(38)35-19-10-6-5-9-18(19)34-22-13-23(33-16-32-22)37(15-17-8-7-11-31-14-17)28(39)36-27-25(29)20(40-2)12-21(41-3)26(27)30/h4-14,16H,1,15H2,2-3H3,(H,35,38)(H,36,39)(H,32,33,34)
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249403
PNG
(US9434697, 120)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(CCCN(C)C)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C27H31Cl2N7O4/c1-6-23(37)33-18-11-8-7-10-17(18)32-21-15-22(31-16-30-21)36(13-9-12-35(2)3)27(38)34-26-24(28)19(39-4)14-20(40-5)25(26)29/h6-8,10-11,14-16H,1,9,12-13H2,2-5H3,(H,33,37)(H,34,38)(H,30,31,32)
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249429
PNG
(US9434697, 149)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)C(=O)N(C)C)ncn2)c1Cl
Show InChI InChI=1S/C26H27Cl2N7O5/c1-7-21(36)32-16-10-14(25(37)34(2)3)8-9-15(16)31-19-12-20(30-13-29-19)35(4)26(38)33-24-22(27)17(39-5)11-18(40-6)23(24)28/h7-13H,1H2,2-6H3,(H,32,36)(H,33,38)(H,29,30,31)
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249437
PNG
(US9434697, 158)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N(C)CCO)ncn2)c1Cl
Show InChI InChI=1S/C26H29Cl2N7O5/c1-6-22(37)32-17-11-15(34(2)9-10-36)7-8-16(17)31-20-13-21(30-14-29-20)35(3)26(38)33-25-23(27)18(39-4)12-19(40-5)24(25)28/h6-8,11-14,36H,1,9-10H2,2-5H3,(H,32,37)(H,33,38)(H,29,30,31)
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249404
PNG
(US9434697, 121)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(CCCN2CCN(C)CC2)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C30H36Cl2N8O4/c1-5-26(41)36-21-10-7-6-9-20(21)35-24-18-25(34-19-33-24)40(12-8-11-39-15-13-38(2)14-16-39)30(42)37-29-27(31)22(43-3)17-23(44-4)28(29)32/h5-7,9-10,17-19H,1,8,11-16H2,2-4H3,(H,36,41)(H,37,42)(H,33,34,35)
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249406
PNG
(US9434697, 123)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCOCC3)ncn2)c1Cl
Show InChI InChI=1S/C27H29Cl2N7O5/c1-5-23(37)33-18-12-16(36-8-10-41-11-9-36)6-7-17(18)32-21-14-22(31-15-30-21)35(2)27(38)34-26-24(28)19(39-3)13-20(40-4)25(26)29/h5-7,12-15H,1,8-11H2,2-4H3,(H,33,37)(H,34,38)(H,30,31,32)
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249408
PNG
(US9434697, 125)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCN(CC3)S(C)(=O)=O)ncn2)c1Cl
Show InChI InChI=1S/C28H32Cl2N8O6S/c1-6-24(39)34-19-13-17(37-9-11-38(12-10-37)45(5,41)42)7-8-18(19)33-22-15-23(32-16-31-22)36(2)28(40)35-27-25(29)20(43-3)14-21(44-4)26(27)30/h6-8,13-16H,1,9-12H2,2-5H3,(H,34,39)(H,35,40)(H,31,32,33)
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249423
PNG
(US9434697, 142)
Show SMILES COCCOc1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C26H28Cl2N6O6/c1-6-22(35)32-17-11-15(40-10-9-37-3)7-8-16(17)31-20-13-21(30-14-29-20)34(2)26(36)33-25-23(27)18(38-4)12-19(39-5)24(25)28/h6-8,11-14H,1,9-10H2,2-5H3,(H,32,35)(H,33,36)(H,29,30,31)
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249425
PNG
(US9434697, 144)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(F)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H34ClFN8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249439
PNG
(US9434697, 160)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)C(C)N)ncn2)c1Cl
Show InChI InChI=1S/C25H27Cl2N7O4/c1-6-21(35)32-16-9-14(13(2)28)7-8-15(16)31-19-11-20(30-12-29-19)34(3)25(36)33-24-22(26)17(37-4)10-18(38-5)23(24)27/h6-13H,1,28H2,2-5H3,(H,32,35)(H,33,36)(H,29,30,31)
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249446
PNG
(US9434697, 167)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3c(Cl)cccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C23H21Cl3N6O4/c1-5-18(33)29-13-8-6-7-12(24)21(13)30-16-10-17(28-11-27-16)32(2)23(34)31-22-19(25)14(35-3)9-15(36-4)20(22)26/h5-11H,1H2,2-4H3,(H,29,33)(H,31,34)(H,27,28,30)
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249391
PNG
(US9434697, 100)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C23H22Cl2N6O4/c1-5-19(32)29-14-9-7-6-8-13(14)28-17-11-18(27-12-26-17)31(2)23(33)30-22-20(24)15(34-3)10-16(35-4)21(22)25/h5-12H,1H2,2-4H3,(H,29,32)(H,30,33)(H,26,27,28)
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249396
PNG
(US9434697, 108)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H34Cl2N8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249409
PNG
(US9434697, 126)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(CCCN(C)C)cc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C28H33Cl2N7O4/c1-7-24(38)34-19-13-17(9-8-12-36(2)3)10-11-18(19)33-22-15-23(32-16-31-22)37(4)28(39)35-27-25(29)20(40-5)14-21(41-6)26(27)30/h7,10-11,13-16H,1,8-9,12H2,2-6H3,(H,34,38)(H,35,39)(H,31,32,33)
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249428
PNG
(US9434697, 148)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)C(=O)N3CCN(C)CC3)ncn2)c1Cl
Show InChI InChI=1S/C29H32Cl2N8O5/c1-6-24(40)35-19-13-17(28(41)39-11-9-37(2)10-12-39)7-8-18(19)34-22-15-23(33-16-32-22)38(3)29(42)36-27-25(30)20(43-4)14-21(44-5)26(27)31/h6-8,13-16H,1,9-12H2,2-5H3,(H,35,40)(H,36,42)(H,32,33,34)
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249430
PNG
(US9434697, 150)
Show SMILES CCN1CCN(CC1)C(=O)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C30H34Cl2N8O5/c1-6-25(41)36-20-14-18(29(42)40-12-10-39(7-2)11-13-40)8-9-19(20)35-23-16-24(34-17-33-23)38(3)30(43)37-28-26(31)21(44-4)15-22(45-5)27(28)32/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,36,41)(H,37,43)(H,33,34,35)
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249435
PNG
(US9434697, 156)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)C(C)O)ncn2)c1Cl
Show InChI InChI=1S/C25H26Cl2N6O5/c1-6-21(35)31-16-9-14(13(2)34)7-8-15(16)30-19-11-20(29-12-28-19)33(3)25(36)32-24-22(26)17(37-4)10-18(38-5)23(24)27/h6-13,34H,1H2,2-5H3,(H,31,35)(H,32,36)(H,28,29,30)
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249438
PNG
(US9434697, 159)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCN(C)CC3)ncn2)c1Cl
Show InChI InChI=1S/C28H32Cl2N8O4/c1-6-24(39)34-19-13-17(38-11-9-36(2)10-12-38)7-8-18(19)33-22-15-23(32-16-31-22)37(3)28(40)35-27-25(29)20(41-4)14-21(42-5)26(27)30/h6-8,13-16H,1,9-12H2,2-5H3,(H,34,39)(H,35,40)(H,31,32,33)
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249391
PNG
(US9434697, 100)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C23H22Cl2N6O4/c1-5-19(32)29-14-9-7-6-8-13(14)28-17-11-18(27-12-26-17)31(2)23(33)30-22-20(24)15(34-3)10-16(35-4)21(22)25/h5-12H,1H2,2-4H3,(H,29,32)(H,30,33)(H,26,27,28)
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249441
PNG
(US9434697, 162)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3c(F)cccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C23H21Cl2FN6O4/c1-5-18(33)29-13-8-6-7-12(26)21(13)30-16-10-17(28-11-27-16)32(2)23(34)31-22-19(24)14(35-3)9-15(36-4)20(22)25/h5-11H,1H2,2-4H3,(H,29,33)(H,31,34)(H,27,28,30)
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249443
PNG
(US9434697, 164)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(OCCO)cc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C25H26Cl2N6O6/c1-5-21(35)31-16-10-14(39-9-8-34)6-7-15(16)30-19-12-20(29-13-28-19)33(2)25(36)32-24-22(26)17(37-3)11-18(38-4)23(24)27/h5-7,10-13,34H,1,8-9H2,2-4H3,(H,31,35)(H,32,36)(H,28,29,30)
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249452
PNG
(US9434697, 181)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)\C=C/Cl)c1
Show InChI InChI=1S/C29H33Cl3N8O4/c1-5-39-10-12-40(13-11-39)18-6-7-19(20(14-18)36-25(41)8-9-30)35-23-16-24(34-17-33-23)38(2)29(42)37-28-26(31)21(43-3)15-22(44-4)27(28)32/h6-9,14-17H,5,10-13H2,1-4H3,(H,36,41)(H,37,42)(H,33,34,35)/b9-8-
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50355393
PNG
(CHEMBL1834657 | US9434697, BGJ398)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)cc1
Show InChI InChI=1S/C26H31Cl2N7O3/c1-5-34-10-12-35(13-11-34)18-8-6-17(7-9-18)31-21-15-22(30-16-29-21)33(2)26(36)32-25-23(27)19(37-3)14-20(38-4)24(25)28/h6-9,14-16H,5,10-13H2,1-4H3,(H,32,36)(H,29,30,31)
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Assay Description
Recombinant FGFR1 (2.5 nM), or FGFR4 (12 nM) was prepared as a mixture with substrate KKKSPGEYVNIEFG (SEQ ID NO:1) (20 μM, FGFR1 substrate); Pol...


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More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249401
PNG
(US9434697, 114)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C#C)ncn2)c1Cl
Show InChI InChI=1S/C23H20Cl2N6O4/c1-5-19(32)29-14-9-7-6-8-13(14)28-17-11-18(27-12-26-17)31(2)23(33)30-22-20(24)15(34-3)10-16(35-4)21(22)25/h1,6-12H,2-4H3,(H,29,32)(H,30,33)(H,26,27,28)
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249410
PNG
(US9434697, 127)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(OCCN(C)C)cc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C27H31Cl2N7O5/c1-7-23(37)33-18-12-16(41-11-10-35(2)3)8-9-17(18)32-21-14-22(31-15-30-21)36(4)27(38)34-26-24(28)19(39-5)13-20(40-6)25(26)29/h7-9,12-15H,1,10-11H2,2-6H3,(H,33,37)(H,34,38)(H,30,31,32)
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249417
PNG
(US9434697, 135)
Show SMILES CCN1CCN(Cc2ccc(Nc3cc(ncn3)N(C)C(=O)Nc3c(Cl)c(OC)cc(OC)c3Cl)c(NC(=O)C=C)c2)CC1
Show InChI InChI=1S/C30H36Cl2N8O4/c1-6-26(41)36-21-14-19(17-40-12-10-39(7-2)11-13-40)8-9-20(21)35-24-16-25(34-18-33-24)38(3)30(42)37-29-27(31)22(43-4)15-23(44-5)28(29)32/h6,8-9,14-16,18H,1,7,10-13,17H2,2-5H3,(H,36,41)(H,37,42)(H,33,34,35)
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249418
PNG
(US9434697, 136)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(Cc2cc(C)no2)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C27H25Cl2N7O5/c1-5-23(37)33-18-9-7-6-8-17(18)32-21-12-22(31-14-30-21)36(13-16-10-15(2)35-41-16)27(38)34-26-24(28)19(39-3)11-20(40-4)25(26)29/h5-12,14H,1,13H2,2-4H3,(H,33,37)(H,34,38)(H,30,31,32)
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249421
PNG
(US9434697, 140)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)cccc2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C27H30Cl2N8O2/c1-4-25(38)33-22-15-18(37-13-11-36(5-2)12-14-37)9-10-21(22)32-23-16-24(31-17-30-23)35(3)27(39)34-26-19(28)7-6-8-20(26)29/h4,6-10,15-17H,1,5,11-14H2,2-3H3,(H,33,38)(H,34,39)(H,30,31,32)
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249426
PNG
(US9434697, 145)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(CO)cc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C24H24Cl2N6O5/c1-5-20(34)30-15-8-13(11-33)6-7-14(15)29-18-10-19(28-12-27-18)32(2)24(35)31-23-21(25)16(36-3)9-17(37-4)22(23)26/h5-10,12,33H,1,11H2,2-4H3,(H,30,34)(H,31,35)(H,27,28,29)
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249413
PNG
(US9434697, 130)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(Cc2ccccc2)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C29H26Cl2N6O4/c1-4-25(38)35-20-13-9-8-12-19(20)34-23-15-24(33-17-32-23)37(16-18-10-6-5-7-11-18)29(39)36-28-26(30)21(40-2)14-22(41-3)27(28)31/h4-15,17H,1,16H2,2-3H3,(H,35,38)(H,36,39)(H,32,33,34)
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249422
PNG
(US9434697, 141)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2cc(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H35ClN8O4/c1-6-27(39)34-22-14-19(38-12-10-37(7-2)11-13-38)8-9-21(22)33-25-17-26(32-18-31-25)36(3)29(40)35-23-15-20(41-4)16-24(42-5)28(23)30/h6,8-9,14-18H,1,7,10-13H2,2-5H3,(H,34,39)(H,35,40)(H,31,32,33)
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249448
PNG
(US9434697, 170 | US9434697, 171)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)\C=C\Cl)ncn2)c1Cl
Show InChI InChI=1S/C23H21Cl3N6O4/c1-32(23(34)31-22-20(25)15(35-2)10-16(36-3)21(22)26)18-11-17(27-12-28-18)29-13-6-4-5-7-14(13)30-19(33)8-9-24/h4-12H,1-3H3,(H,30,33)(H,31,34)(H,27,28,29)/b9-8+
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249416
PNG
(US9434697, 133)
Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)C=C)c(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c1
Show InChI InChI=1S/C29H34Cl2N8O4/c1-6-25(40)35-19-9-8-18(39-12-10-38(7-2)11-13-39)14-20(19)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249402
PNG
(US9434697, 116)
Show SMILES COCCN(C(=O)Nc1c(Cl)c(OC)cc(OC)c1Cl)c1cc(Nc2ccccc2NC(=O)C=C)ncn1
Show InChI InChI=1S/C25H26Cl2N6O5/c1-5-21(34)31-16-9-7-6-8-15(16)30-19-13-20(29-14-28-19)33(10-11-36-2)25(35)32-24-22(26)17(37-3)12-18(38-4)23(24)27/h5-9,12-14H,1,10-11H2,2-4H3,(H,31,34)(H,32,35)(H,28,29,30)
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249420
PNG
(US9434697, 139)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2cc(OC)cc(OC)c2)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H36N8O4/c1-6-28(38)34-25-16-21(37-12-10-36(7-2)11-13-37)8-9-24(25)33-26-18-27(31-19-30-26)35(3)29(39)32-20-14-22(40-4)17-23(15-20)41-5/h6,8-9,14-19H,1,7,10-13H2,2-5H3,(H,32,39)(H,34,38)(H,30,31,33)
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249448
PNG
(US9434697, 170 | US9434697, 171)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)\C=C\Cl)ncn2)c1Cl
Show InChI InChI=1S/C23H21Cl3N6O4/c1-32(23(34)31-22-20(25)15(35-2)10-16(36-3)21(22)26)18-11-17(27-12-28-18)29-13-6-4-5-7-14(13)30-19(33)8-9-24/h4-12H,1-3H3,(H,30,33)(H,31,34)(H,27,28,29)/b9-8+
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249424
PNG
(US9434697, 143)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(F)c(OC)cc(OC)c2F)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H34F2N8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249450
PNG
(US9434697, 172)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)\C=C/C)ncn2)c1Cl
Show InChI InChI=1S/C24H24Cl2N6O4/c1-5-8-20(33)30-15-10-7-6-9-14(15)29-18-12-19(28-13-27-18)32(2)24(34)31-23-21(25)16(35-3)11-17(36-4)22(23)26/h5-13H,1-4H3,(H,30,33)(H,31,34)(H,27,28,29)/b8-5-
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM50355393
PNG
(CHEMBL1834657 | US9434697, BGJ398)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)cc1
Show InChI InChI=1S/C26H31Cl2N7O3/c1-5-34-10-12-35(13-11-34)18-8-6-17(7-9-18)31-21-15-22(30-16-29-21)33(2)26(36)32-25-23(27)19(37-3)14-20(38-4)24(25)28/h6-9,14-16H,5,10-13H2,1-4H3,(H,32,36)(H,29,30,31)
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n/an/a 13n/an/an/an/an/an/a



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), or FGFR4 (12 nM) was prepared as a mixture with substrate KKKSPGEYVNIEFG (SEQ ID NO:1) (20 μM, FGFR1 substrate); Pol...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249455
PNG
(US9434697, 185)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3cccc(F)c3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C23H21Cl2FN6O4/c1-5-18(33)30-21-12(26)7-6-8-13(21)29-16-10-17(28-11-27-16)32(2)23(34)31-22-19(24)14(35-3)9-15(36-4)20(22)25/h5-11H,1H2,2-4H3,(H,30,33)(H,31,34)(H,27,28,29)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249432
PNG
(US9434697, 152)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(c1)N(C)C(=O)C=C
Show InChI InChI=1S/C30H36Cl2N8O4/c1-7-26(41)37(3)21-15-19(40-13-11-39(8-2)12-14-40)9-10-20(21)35-24-17-25(34-18-33-24)38(4)30(42)36-29-27(31)22(43-5)16-23(44-6)28(29)32/h7,9-10,15-18H,1,8,11-14H2,2-6H3,(H,36,42)(H,33,34,35)
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US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249451
PNG
(US9434697, 175)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C(C)=C)ncn2)c1Cl
Show InChI InChI=1S/C24H24Cl2N6O4/c1-13(2)23(33)30-15-9-7-6-8-14(15)29-18-11-19(28-12-27-18)32(3)24(34)31-22-20(25)16(35-4)10-17(36-5)21(22)26/h6-12H,1H2,2-5H3,(H,30,33)(H,31,34)(H,27,28,29)
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249397
PNG
(US9434697, 110)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C(F)=C)ncn2)c1Cl
Show InChI InChI=1S/C23H21Cl2FN6O4/c1-12(26)22(33)30-14-8-6-5-7-13(14)29-17-10-18(28-11-27-17)32(2)23(34)31-21-19(24)15(35-3)9-16(36-4)20(21)25/h5-11H,1H2,2-4H3,(H,30,33)(H,31,34)(H,27,28,29)
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US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249411
PNG
(US9434697, 128)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C#CC)ncn2)c1Cl
Show InChI InChI=1S/C24H22Cl2N6O4/c1-5-8-20(33)30-15-10-7-6-9-14(15)29-18-12-19(28-13-27-18)32(2)24(34)31-23-21(25)16(35-3)11-17(36-4)22(23)26/h6-7,9-13H,1-4H3,(H,30,33)(H,31,34)(H,27,28,29)
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249401
PNG
(US9434697, 114)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C#C)ncn2)c1Cl
Show InChI InChI=1S/C23H20Cl2N6O4/c1-5-19(32)29-14-9-7-6-8-13(14)28-17-11-18(27-12-26-17)31(2)23(33)30-22-20(24)15(34-3)10-16(35-4)21(22)25/h1,6-12H,2-4H3,(H,29,32)(H,30,33)(H,26,27,28)
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249412
PNG
(US9434697, 129)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)\C=C\C)ncn2)c1Cl
Show InChI InChI=1S/C24H24Cl2N6O4/c1-5-8-20(33)30-15-10-7-6-9-14(15)29-18-12-19(28-13-27-18)32(2)24(34)31-23-21(25)16(35-3)11-17(36-4)22(23)26/h5-13H,1-4H3,(H,30,33)(H,31,34)(H,27,28,29)/b8-5+
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249454
PNG
(US9434697, 184)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3cccc(C)c3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C24H24Cl2N6O4/c1-6-19(33)30-22-13(2)8-7-9-14(22)29-17-11-18(28-12-27-17)32(3)24(34)31-23-20(25)15(35-4)10-16(36-5)21(23)26/h6-12H,1H2,2-5H3,(H,30,33)(H,31,34)(H,27,28,29)
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249425
PNG
(US9434697, 144)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(F)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H34ClFN8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249418
PNG
(US9434697, 136)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(Cc2cc(C)no2)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C27H25Cl2N7O5/c1-5-23(37)33-18-9-7-6-8-17(18)32-21-12-22(31-14-30-21)36(13-16-10-15(2)35-41-16)27(38)34-26-24(28)19(39-3)11-20(40-4)25(26)29/h5-12,14H,1,13H2,2-4H3,(H,33,37)(H,34,38)(H,30,31,32)
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US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249438
PNG
(US9434697, 159)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCN(C)CC3)ncn2)c1Cl
Show InChI InChI=1S/C28H32Cl2N8O4/c1-6-24(39)34-19-13-17(38-11-9-36(2)10-12-38)7-8-18(19)33-22-15-23(32-16-31-22)37(3)28(40)35-27-25(29)20(41-4)14-21(42-5)26(27)30/h6-8,13-16H,1,9-12H2,2-5H3,(H,34,39)(H,35,40)(H,31,32,33)
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US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249436
PNG
(US9434697, 157)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCNCC3)ncn2)c1Cl
Show InChI InChI=1S/C27H30Cl2N8O4/c1-5-23(38)34-18-12-16(37-10-8-30-9-11-37)6-7-17(18)33-21-14-22(32-15-31-21)36(2)27(39)35-26-24(28)19(40-3)13-20(41-4)25(26)29/h5-7,12-15,30H,1,8-11H2,2-4H3,(H,34,38)(H,35,39)(H,31,32,33)
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US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249424
PNG
(US9434697, 143)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(F)c(OC)cc(OC)c2F)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H34F2N8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)
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US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249407
PNG
(US9434697, 124)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3C[C@H](C)N[C@H](C)C3)ncn2)c1Cl
Show InChI InChI=1S/C29H34Cl2N8O4/c1-7-25(40)36-20-10-18(39-13-16(2)34-17(3)14-39)8-9-19(20)35-23-12-24(33-15-32-23)38(4)29(41)37-28-26(30)21(42-5)11-22(43-6)27(28)31/h7-12,15-17,34H,1,13-14H2,2-6H3,(H,36,40)(H,37,41)(H,32,33,35)/t16-,17+
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249396
PNG
(US9434697, 108)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H34Cl2N8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)
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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249396
PNG
(US9434697, 108)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H34Cl2N8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)
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US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249453
PNG
(US9434697, 183)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(CCNC(C)C)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C27H31Cl2N7O4/c1-6-23(37)34-18-10-8-7-9-17(18)33-21-14-22(32-15-31-21)36(12-11-30-16(2)3)27(38)35-26-24(28)19(39-4)13-20(40-5)25(26)29/h6-10,13-16,30H,1,11-12H2,2-5H3,(H,34,37)(H,35,38)(H,31,32,33)
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US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249431
PNG
(US9434697, 151)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCN(CC3)C(C)C)ncn2)c1Cl
Show InChI InChI=1S/C30H36Cl2N8O4/c1-7-26(41)36-21-14-19(40-12-10-39(11-13-40)18(2)3)8-9-20(21)35-24-16-25(34-17-33-24)38(4)30(42)37-29-27(31)22(43-5)15-23(44-6)28(29)32/h7-9,14-18H,1,10-13H2,2-6H3,(H,36,41)(H,37,42)(H,33,34,35)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249394
PNG
(US9434697, 105)
Show SMILES COc1cc(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c(Cl)c(OC)c1
Show InChI InChI=1S/C23H23ClN6O4/c1-5-21(31)28-16-9-7-6-8-15(16)27-19-12-20(26-13-25-19)30(2)23(32)29-17-10-14(33-3)11-18(34-4)22(17)24/h5-13H,1H2,2-4H3,(H,28,31)(H,29,32)(H,25,26,27)
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n/an/a 201n/an/an/an/an/an/a



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249452
PNG
(US9434697, 181)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)\C=C/Cl)c1
Show InChI InChI=1S/C29H33Cl3N8O4/c1-5-39-10-12-40(13-11-39)18-6-7-19(20(14-18)36-25(41)8-9-30)35-23-16-24(34-17-33-23)38(2)29(42)37-28-26(31)21(43-3)15-22(44-4)27(28)32/h6-9,14-17H,5,10-13H2,1-4H3,(H,36,41)(H,37,42)(H,33,34,35)/b9-8-
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249432
PNG
(US9434697, 152)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(c1)N(C)C(=O)C=C
Show InChI InChI=1S/C30H36Cl2N8O4/c1-7-26(41)37(3)21-15-19(40-13-11-39(8-2)12-14-40)9-10-20(21)35-24-17-25(34-18-33-24)38(4)30(42)36-29-27(31)22(43-5)16-23(44-6)28(29)32/h7,9-10,15-18H,1,8,11-14H2,2-6H3,(H,36,42)(H,33,34,35)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249405
PNG
(US9434697, 122)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)C3CCNCC3)ncn2)c1Cl
Show InChI InChI=1S/C28H31Cl2N7O4/c1-5-24(38)35-19-12-17(16-8-10-31-11-9-16)6-7-18(19)34-22-14-23(33-15-32-22)37(2)28(39)36-27-25(29)20(40-3)13-21(41-4)26(27)30/h5-7,12-16,31H,1,8-11H2,2-4H3,(H,35,38)(H,36,39)(H,32,33,34)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249456
PNG
(US9434697, 186)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3cccc(OC)c3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C24H24Cl2N6O5/c1-6-19(33)30-22-13(8-7-9-14(22)35-3)29-17-11-18(28-12-27-17)32(2)24(34)31-23-20(25)15(36-4)10-16(37-5)21(23)26/h6-12H,1H2,2-5H3,(H,30,33)(H,31,34)(H,27,28,29)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249415
PNG
(US9434697, 132)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(Cc2ccncc2)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C28H25Cl2N7O4/c1-4-24(38)35-19-8-6-5-7-18(19)34-22-14-23(33-16-32-22)37(15-17-9-11-31-12-10-17)28(39)36-27-25(29)20(40-2)13-21(41-3)26(27)30/h4-14,16H,1,15H2,2-3H3,(H,35,38)(H,36,39)(H,32,33,34)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249396
PNG
(US9434697, 108)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H34Cl2N8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), or FGFR4 (12 nM) was prepared as a mixture with substrate KKKSPGEYVNIEFG (SEQ ID NO:1) (20 μM, FGFR1 substrate); Pol...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249442
PNG
(US9434697, 163)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(CCN(C)C)cc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C27H31Cl2N7O4/c1-7-23(37)33-18-12-16(10-11-35(2)3)8-9-17(18)32-21-14-22(31-15-30-21)36(4)27(38)34-26-24(28)19(39-5)13-20(40-6)25(26)29/h7-9,12-15H,1,10-11H2,2-6H3,(H,33,37)(H,34,38)(H,30,31,32)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249409
PNG
(US9434697, 126)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(CCCN(C)C)cc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C28H33Cl2N7O4/c1-7-24(38)34-19-13-17(9-8-12-36(2)3)10-11-18(19)33-22-15-23(32-16-31-22)37(4)28(39)35-27-25(29)20(40-5)14-21(41-6)26(27)30/h7,10-11,13-16H,1,8-9,12H2,2-6H3,(H,34,38)(H,35,39)(H,31,32,33)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249400
PNG
(US9434697, 113)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(CN(C)C)cc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C26H29Cl2N7O4/c1-7-22(36)32-17-10-15(13-34(2)3)8-9-16(17)31-20-12-21(30-14-29-20)35(4)26(37)33-25-23(27)18(38-5)11-19(39-6)24(25)28/h7-12,14H,1,13H2,2-6H3,(H,32,36)(H,33,37)(H,29,30,31)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249439
PNG
(US9434697, 160)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)C(C)N)ncn2)c1Cl
Show InChI InChI=1S/C25H27Cl2N7O4/c1-6-21(35)32-16-9-14(13(2)28)7-8-15(16)31-19-11-20(30-12-29-19)34(3)25(36)33-24-22(26)17(37-4)10-18(38-5)23(24)27/h6-13H,1,28H2,2-5H3,(H,32,35)(H,33,36)(H,29,30,31)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249393
PNG
(US9434697, 103)
Show SMILES COc1cccc(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C22H21ClN6O3/c1-4-20(30)27-15-9-6-5-8-14(15)26-18-12-19(25-13-24-18)29(2)22(31)28-16-10-7-11-17(32-3)21(16)23/h4-13H,1H2,2-3H3,(H,27,30)(H,28,31)(H,24,25,26)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249395
PNG
(US9434697, 107)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(Cc2cccnc2)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C28H25Cl2N7O4/c1-4-24(38)35-19-10-6-5-9-18(19)34-22-13-23(33-16-32-22)37(15-17-8-7-11-31-14-17)28(39)36-27-25(29)20(40-2)12-21(41-3)26(27)30/h4-14,16H,1,15H2,2-3H3,(H,35,38)(H,36,39)(H,32,33,34)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249433
PNG
(US9434697, 154)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCN(CC3)C(C)=O)ncn2)c1Cl
Show InChI InChI=1S/C29H32Cl2N8O5/c1-6-25(41)35-20-13-18(39-11-9-38(10-12-39)17(2)40)7-8-19(20)34-23-15-24(33-16-32-23)37(3)29(42)36-28-26(30)21(43-4)14-22(44-5)27(28)31/h6-8,13-16H,1,9-12H2,2-5H3,(H,35,41)(H,36,42)(H,32,33,34)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249392
PNG
(US9434697, 102)
Show SMILES COc1cc(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)cc(OC)c1
Show InChI InChI=1S/C23H24N6O4/c1-5-22(30)28-19-9-7-6-8-18(19)27-20-13-21(25-14-24-20)29(2)23(31)26-15-10-16(32-3)12-17(11-15)33-4/h5-14H,1H2,2-4H3,(H,26,31)(H,28,30)(H,24,25,27)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249404
PNG
(US9434697, 121)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(CCCN2CCN(C)CC2)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C30H36Cl2N8O4/c1-5-26(41)36-21-10-7-6-9-20(21)35-24-18-25(34-19-33-24)40(12-8-11-39-15-13-38(2)14-16-39)30(42)37-29-27(31)22(43-3)17-23(44-4)28(29)32/h5-7,9-10,17-19H,1,8,11-16H2,2-4H3,(H,36,41)(H,37,42)(H,33,34,35)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249447
PNG
(US9434697, 168)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCN(CCO)CC3)ncn2)c1Cl
Show InChI InChI=1S/C29H34Cl2N8O5/c1-5-25(41)35-20-14-18(39-10-8-38(9-11-39)12-13-40)6-7-19(20)34-23-16-24(33-17-32-23)37(2)29(42)36-28-26(30)21(43-3)15-22(44-4)27(28)31/h5-7,14-17,40H,1,8-13H2,2-4H3,(H,35,41)(H,36,42)(H,32,33,34)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249414
PNG
(US9434697, 131)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(Cc2ccccn2)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C28H25Cl2N7O4/c1-4-24(38)35-19-11-6-5-10-18(19)34-22-14-23(33-16-32-22)37(15-17-9-7-8-12-31-17)28(39)36-27-25(29)20(40-2)13-21(41-3)26(27)30/h4-14,16H,1,15H2,2-3H3,(H,35,38)(H,36,39)(H,32,33,34)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249403
PNG
(US9434697, 120)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(CCCN(C)C)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C27H31Cl2N7O4/c1-6-23(37)33-18-11-8-7-10-17(18)32-21-15-22(31-16-30-21)36(13-9-12-35(2)3)27(38)34-26-24(28)19(39-4)14-20(40-5)25(26)29/h6-8,10-11,14-16H,1,9,12-13H2,2-5H3,(H,33,37)(H,34,38)(H,30,31,32)
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n/an/a 1.19E+3n/an/an/an/an/an/a



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249398
PNG
(US9434697, 111)
Show SMILES CCN1CCC(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C30H35Cl2N7O4/c1-6-26(40)36-21-14-19(18-10-12-39(7-2)13-11-18)8-9-20(21)35-24-16-25(34-17-33-24)38(3)30(41)37-29-27(31)22(42-4)15-23(43-5)28(29)32/h6,8-9,14-18H,1,7,10-13H2,2-5H3,(H,36,40)(H,37,41)(H,33,34,35)
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n/an/a 1.28E+3n/an/an/an/an/an/a



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249411
PNG
(US9434697, 128)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C#CC)ncn2)c1Cl
Show InChI InChI=1S/C24H22Cl2N6O4/c1-5-8-20(33)30-15-10-7-6-9-14(15)29-18-12-19(28-13-27-18)32(2)24(34)31-23-21(25)16(35-3)11-17(36-4)22(23)26/h6-7,9-13H,1-4H3,(H,30,33)(H,31,34)(H,27,28,29)
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n/an/a 1.68E+3n/an/an/an/an/an/a



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249435
PNG
(US9434697, 156)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)C(C)O)ncn2)c1Cl
Show InChI InChI=1S/C25H26Cl2N6O5/c1-6-21(35)31-16-9-14(13(2)34)7-8-15(16)30-19-11-20(29-12-28-19)33(3)25(36)32-24-22(26)17(37-4)10-18(38-5)23(24)27/h6-13,34H,1H2,2-5H3,(H,31,35)(H,32,36)(H,28,29,30)
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n/an/a 1.95E+3n/an/an/an/an/an/a



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM249391
PNG
(US9434697, 100)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C23H22Cl2N6O4/c1-5-19(32)29-14-9-7-6-8-13(14)28-17-11-18(27-12-26-17)31(2)23(33)30-22-20(24)15(34-3)10-16(35-4)21(22)25/h5-12H,1H2,2-4H3,(H,29,32)(H,30,33)(H,26,27,28)
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n/an/a 1.98E+3n/an/an/an/an/an/a



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US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM249396
PNG
(US9434697, 108)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H34Cl2N8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM249396
PNG
(US9434697, 108)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H34Cl2N8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249417
PNG
(US9434697, 135)
Show SMILES CCN1CCN(Cc2ccc(Nc3cc(ncn3)N(C)C(=O)Nc3c(Cl)c(OC)cc(OC)c3Cl)c(NC(=O)C=C)c2)CC1
Show InChI InChI=1S/C30H36Cl2N8O4/c1-6-26(41)36-21-14-19(17-40-12-10-39(7-2)11-13-40)8-9-20(21)35-24-16-25(34-18-33-24)38(3)30(42)37-29-27(31)22(43-4)15-23(44-5)28(29)32/h6,8-9,14-16,18H,1,7,10-13,17H2,2-5H3,(H,36,41)(H,37,42)(H,33,34,35)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249437
PNG
(US9434697, 158)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N(C)CCO)ncn2)c1Cl
Show InChI InChI=1S/C26H29Cl2N7O5/c1-6-22(37)32-17-11-15(34(2)9-10-36)7-8-16(17)31-20-13-21(30-14-29-20)35(3)26(38)33-25-23(27)18(39-4)12-19(40-5)24(25)28/h6-8,11-14,36H,1,9-10H2,2-5H3,(H,32,37)(H,33,38)(H,29,30,31)
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n/an/a 2.15E+3n/an/an/an/an/an/a



EISAI R&D MANAGEMENT CO., LTD.

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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249426
PNG
(US9434697, 145)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(CO)cc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C24H24Cl2N6O5/c1-5-20(34)30-15-8-13(11-33)6-7-14(15)29-18-10-19(28-12-27-18)32(2)24(35)31-23-21(25)16(36-3)9-17(37-4)22(23)26/h5-10,12,33H,1,11H2,2-4H3,(H,30,34)(H,31,35)(H,27,28,29)
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US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249430
PNG
(US9434697, 150)
Show SMILES CCN1CCN(CC1)C(=O)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C30H34Cl2N8O5/c1-6-25(41)36-20-14-18(29(42)40-12-10-39(7-2)11-13-40)8-9-19(20)35-23-16-24(34-17-33-23)38(3)30(43)37-28-26(31)21(44-4)15-22(45-5)27(28)32/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,36,41)(H,37,43)(H,33,34,35)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249399
PNG
(US9434697, 112)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)C3CCN(C)CC3)ncn2)c1Cl
Show InChI InChI=1S/C29H33Cl2N7O4/c1-6-25(39)35-20-13-18(17-9-11-37(2)12-10-17)7-8-19(20)34-23-15-24(33-16-32-23)38(3)29(40)36-28-26(30)21(41-4)14-22(42-5)27(28)31/h6-8,13-17H,1,9-12H2,2-5H3,(H,35,39)(H,36,40)(H,32,33,34)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249440
PNG
(US9434697, 161)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCN(CCN)CC3)ncn2)c1Cl
Show InChI InChI=1S/C29H35Cl2N9O4/c1-5-25(41)36-20-14-18(40-12-10-39(9-8-32)11-13-40)6-7-19(20)35-23-16-24(34-17-33-23)38(2)29(42)37-28-26(30)21(43-3)15-22(44-4)27(28)31/h5-7,14-17H,1,8-13,32H2,2-4H3,(H,36,41)(H,37,42)(H,33,34,35)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249408
PNG
(US9434697, 125)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCN(CC3)S(C)(=O)=O)ncn2)c1Cl
Show InChI InChI=1S/C28H32Cl2N8O6S/c1-6-24(39)34-19-13-17(37-9-11-38(12-10-37)45(5,41)42)7-8-18(19)33-22-15-23(32-16-31-22)36(2)28(40)35-27-25(29)20(43-3)14-21(44-4)26(27)30/h6-8,13-16H,1,9-12H2,2-5H3,(H,34,39)(H,35,40)(H,31,32,33)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249410
PNG
(US9434697, 127)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(OCCN(C)C)cc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C27H31Cl2N7O5/c1-7-23(37)33-18-12-16(41-11-10-35(2)3)8-9-17(18)32-21-14-22(31-15-30-21)36(4)27(38)34-26-24(28)19(39-5)13-20(40-6)25(26)29/h7-9,12-15H,1,10-11H2,2-6H3,(H,33,37)(H,34,38)(H,30,31,32)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249443
PNG
(US9434697, 164)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(OCCO)cc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C25H26Cl2N6O6/c1-5-21(35)31-16-10-14(39-9-8-34)6-7-15(16)30-19-12-20(29-13-28-19)33(2)25(36)32-24-22(26)17(37-3)11-18(38-4)23(24)27/h5-7,10-13,34H,1,8-9H2,2-4H3,(H,31,35)(H,32,36)(H,28,29,30)
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n/an/a 3.51E+3n/an/an/an/an/an/a



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249406
PNG
(US9434697, 123)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCOCC3)ncn2)c1Cl
Show InChI InChI=1S/C27H29Cl2N7O5/c1-5-23(37)33-18-12-16(36-8-10-41-11-9-36)6-7-17(18)32-21-14-22(31-15-30-21)35(2)27(38)34-26-24(28)19(39-3)13-20(40-4)25(26)29/h5-7,12-15H,1,8-11H2,2-4H3,(H,33,37)(H,34,38)(H,30,31,32)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249448
PNG
(US9434697, 170 | US9434697, 171)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)\C=C\Cl)ncn2)c1Cl
Show InChI InChI=1S/C23H21Cl3N6O4/c1-32(23(34)31-22-20(25)15(35-2)10-16(36-3)21(22)26)18-11-17(27-12-28-18)29-13-6-4-5-7-14(13)30-19(33)8-9-24/h4-12H,1-3H3,(H,30,33)(H,31,34)(H,27,28,29)/b9-8+
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM249391
PNG
(US9434697, 100)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C23H22Cl2N6O4/c1-5-19(32)29-14-9-7-6-8-13(14)28-17-11-18(27-12-26-17)31(2)23(33)30-22-20(24)15(34-3)10-16(35-4)21(22)25/h5-12H,1H2,2-4H3,(H,29,32)(H,30,33)(H,26,27,28)
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n/an/a 4.18E+3n/an/an/an/an/an/a



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249445
PNG
(US9434697, 166)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3c(NC(=O)C=C)cccc3OC)ncn2)c1Cl
Show InChI InChI=1S/C24H24Cl2N6O5/c1-6-19(33)29-13-8-7-9-14(35-3)22(13)30-17-11-18(28-12-27-17)32(2)24(34)31-23-20(25)15(36-4)10-16(37-5)21(23)26/h6-12H,1H2,2-5H3,(H,29,33)(H,31,34)(H,27,28,30)
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n/an/a 4.92E+3n/an/an/an/an/an/a



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249427
PNG
(US9434697, 147)
Show SMILES COCc1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C25H26Cl2N6O5/c1-6-21(34)31-16-9-14(12-36-3)7-8-15(16)30-19-11-20(29-13-28-19)33(2)25(35)32-24-22(26)17(37-4)10-18(38-5)23(24)27/h6-11,13H,1,12H2,2-5H3,(H,31,34)(H,32,35)(H,28,29,30)
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n/an/a 5.94E+3n/an/an/an/an/an/a



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249453
PNG
(US9434697, 183)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(CCNC(C)C)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C27H31Cl2N7O4/c1-6-23(37)34-18-10-8-7-9-17(18)33-21-14-22(32-15-31-21)36(12-11-30-16(2)3)27(38)35-26-24(28)19(39-4)13-20(40-5)25(26)29/h6-10,13-16,30H,1,11-12H2,2-5H3,(H,34,37)(H,35,38)(H,31,32,33)
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n/an/a 6.21E+3n/an/an/an/an/an/a



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249428
PNG
(US9434697, 148)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)C(=O)N3CCN(C)CC3)ncn2)c1Cl
Show InChI InChI=1S/C29H32Cl2N8O5/c1-6-24(40)35-19-13-17(28(41)39-11-9-37(2)10-12-39)7-8-18(19)34-22-15-23(33-16-32-22)38(3)29(42)36-27-25(30)20(43-4)14-21(44-5)26(27)31/h6-8,13-16H,1,9-12H2,2-5H3,(H,35,40)(H,36,42)(H,32,33,34)
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n/an/a 6.44E+3n/an/an/an/an/an/a



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249454
PNG
(US9434697, 184)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3cccc(C)c3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C24H24Cl2N6O4/c1-6-19(33)30-22-13(2)8-7-9-14(22)29-17-11-18(28-12-27-17)32(3)24(34)31-23-20(25)15(35-4)10-16(36-5)21(23)26/h6-12H,1H2,2-5H3,(H,30,33)(H,31,34)(H,27,28,29)
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n/an/a 6.48E+3n/an/an/an/an/an/a



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249450
PNG
(US9434697, 172)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)\C=C/C)ncn2)c1Cl
Show InChI InChI=1S/C24H24Cl2N6O4/c1-5-8-20(33)30-15-10-7-6-9-14(15)29-18-12-19(28-13-27-18)32(2)24(34)31-23-21(25)16(35-3)11-17(36-4)22(23)26/h5-13H,1-4H3,(H,30,33)(H,31,34)(H,27,28,29)/b8-5-
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n/an/a 7.37E+3n/an/an/an/an/an/a



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249444
PNG
(US9434697, 165)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3c(C)cccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C24H24Cl2N6O4/c1-6-19(33)29-14-9-7-8-13(2)22(14)30-17-11-18(28-12-27-17)32(3)24(34)31-23-20(25)15(35-4)10-16(36-5)21(23)26/h6-12H,1H2,2-5H3,(H,29,33)(H,31,34)(H,27,28,30)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249429
PNG
(US9434697, 149)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)C(=O)N(C)C)ncn2)c1Cl
Show InChI InChI=1S/C26H27Cl2N7O5/c1-7-21(36)32-16-10-14(25(37)34(2)3)8-9-15(16)31-19-12-20(30-13-29-19)35(4)26(38)33-24-22(27)17(39-5)11-18(40-6)23(24)28/h7-13H,1H2,2-6H3,(H,32,36)(H,33,38)(H,29,30,31)
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n/an/a 7.70E+3n/an/an/an/an/an/a



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249434
PNG
(US9434697, 155)
Show SMILES COC(C)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C26H28Cl2N6O5/c1-7-22(35)32-17-10-15(14(2)37-4)8-9-16(17)31-20-12-21(30-13-29-20)34(3)26(36)33-25-23(27)18(38-5)11-19(39-6)24(25)28/h7-14H,1H2,2-6H3,(H,32,35)(H,33,36)(H,29,30,31)
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n/an/a 8.03E+3n/an/an/an/an/an/a



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249416
PNG
(US9434697, 133)
Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)C=C)c(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c1
Show InChI InChI=1S/C29H34Cl2N8O4/c1-6-25(40)35-19-9-8-18(39-12-10-38(7-2)11-13-39)14-20(19)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249412
PNG
(US9434697, 129)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)\C=C\C)ncn2)c1Cl
Show InChI InChI=1S/C24H24Cl2N6O4/c1-5-8-20(33)30-15-10-7-6-9-14(15)29-18-12-19(28-13-27-18)32(2)24(34)31-23-21(25)16(35-3)11-17(36-4)22(23)26/h5-13H,1-4H3,(H,30,33)(H,31,34)(H,27,28,29)/b8-5+
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249393
PNG
(US9434697, 103)
Show SMILES COc1cccc(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C22H21ClN6O3/c1-4-20(30)27-15-9-6-5-8-14(15)26-18-12-19(25-13-24-18)29(2)22(31)28-16-10-7-11-17(32-3)21(16)23/h4-13H,1H2,2-3H3,(H,27,30)(H,28,31)(H,24,25,26)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249392
PNG
(US9434697, 102)
Show SMILES COc1cc(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)cc(OC)c1
Show InChI InChI=1S/C23H24N6O4/c1-5-22(30)28-19-9-7-6-8-18(19)27-20-13-21(25-14-24-20)29(2)23(31)26-15-10-16(32-3)12-17(11-15)33-4/h5-14H,1H2,2-4H3,(H,26,31)(H,28,30)(H,24,25,27)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249455
PNG
(US9434697, 185)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3cccc(F)c3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C23H21Cl2FN6O4/c1-5-18(33)30-21-12(26)7-6-8-13(21)29-16-10-17(28-11-27-16)32(2)23(34)31-22-19(24)14(35-3)9-15(36-4)20(22)25/h5-11H,1H2,2-4H3,(H,30,33)(H,31,34)(H,27,28,29)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249394
PNG
(US9434697, 105)
Show SMILES COc1cc(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c(Cl)c(OC)c1
Show InChI InChI=1S/C23H23ClN6O4/c1-5-21(31)28-16-9-7-6-8-15(16)27-19-12-20(26-13-25-19)30(2)23(32)29-17-10-14(33-3)11-18(34-4)22(17)24/h5-13H,1H2,2-4H3,(H,28,31)(H,29,32)(H,25,26,27)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249441
PNG
(US9434697, 162)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3c(F)cccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C23H21Cl2FN6O4/c1-5-18(33)29-13-8-6-7-12(26)21(13)30-16-10-17(28-11-27-16)32(2)23(34)31-22-19(24)14(35-3)9-15(36-4)20(22)25/h5-11H,1H2,2-4H3,(H,29,33)(H,31,34)(H,27,28,30)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249456
PNG
(US9434697, 186)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3cccc(OC)c3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C24H24Cl2N6O5/c1-6-19(33)30-22-13(8-7-9-14(22)35-3)29-17-11-18(28-12-27-17)32(2)24(34)31-23-20(25)15(36-4)10-16(37-5)21(23)26/h6-12H,1H2,2-5H3,(H,30,33)(H,31,34)(H,27,28,29)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249446
PNG
(US9434697, 167)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3c(Cl)cccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C23H21Cl3N6O4/c1-5-18(33)29-13-8-6-7-12(24)21(13)30-16-10-17(28-11-27-16)32(2)23(34)31-22-19(25)14(35-3)9-15(36-4)20(22)26/h5-11H,1H2,2-4H3,(H,29,33)(H,31,34)(H,27,28,30)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249423
PNG
(US9434697, 142)
Show SMILES COCCOc1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C26H28Cl2N6O6/c1-6-22(35)32-17-11-15(40-10-9-37-3)7-8-16(17)31-20-13-21(30-14-29-20)34(2)26(36)33-25-23(27)18(38-4)12-19(39-5)24(25)28/h6-8,11-14H,1,9-10H2,2-5H3,(H,32,35)(H,33,36)(H,29,30,31)
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n/an/a>1.00E+4n/an/an/an/an/an/a



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249451
PNG
(US9434697, 175)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C(C)=C)ncn2)c1Cl
Show InChI InChI=1S/C24H24Cl2N6O4/c1-13(2)23(33)30-15-9-7-6-8-14(15)29-18-11-19(28-12-27-18)32(3)24(34)31-22-20(25)16(35-4)10-17(36-5)21(22)26/h6-12H,1H2,2-5H3,(H,30,33)(H,31,34)(H,27,28,29)
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n/an/a>1.00E+4n/an/an/an/an/an/a



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249419
PNG
(US9434697, 137)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3cc(CCN(C)C)ccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C27H31Cl2N7O4/c1-7-23(37)33-17-9-8-16(10-11-35(2)3)12-18(17)32-21-14-22(31-15-30-21)36(4)27(38)34-26-24(28)19(39-5)13-20(40-6)25(26)29/h7-9,12-15H,1,10-11H2,2-6H3,(H,33,37)(H,34,38)(H,30,31,32)
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n/an/a>1.00E+4n/an/an/an/an/an/a



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249413
PNG
(US9434697, 130)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(Cc2ccccc2)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C29H26Cl2N6O4/c1-4-25(38)35-20-13-9-8-12-19(20)34-23-15-24(33-17-32-23)37(16-18-10-6-5-7-11-18)29(39)36-28-26(30)21(40-2)14-22(41-3)27(28)31/h4-15,17H,1,16H2,2-3H3,(H,35,38)(H,36,39)(H,32,33,34)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249391
PNG
(US9434697, 100)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C23H22Cl2N6O4/c1-5-19(32)29-14-9-7-6-8-13(14)28-17-11-18(27-12-26-17)31(2)23(33)30-22-20(24)15(34-3)10-16(35-4)21(22)25/h5-12H,1H2,2-4H3,(H,29,32)(H,30,33)(H,26,27,28)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249448
PNG
(US9434697, 170 | US9434697, 171)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)\C=C\Cl)ncn2)c1Cl
Show InChI InChI=1S/C23H21Cl3N6O4/c1-32(23(34)31-22-20(25)15(35-2)10-16(36-3)21(22)26)18-11-17(27-12-28-18)29-13-6-4-5-7-14(13)30-19(33)8-9-24/h4-12H,1-3H3,(H,30,33)(H,31,34)(H,27,28,29)/b9-8+
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n/an/a>1.00E+4n/an/an/an/an/an/a



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249391
PNG
(US9434697, 100)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C23H22Cl2N6O4/c1-5-19(32)29-14-9-7-6-8-13(14)28-17-11-18(27-12-26-17)31(2)23(33)30-22-20(24)15(34-3)10-16(35-4)21(22)25/h5-12H,1H2,2-4H3,(H,29,32)(H,30,33)(H,26,27,28)
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n/an/a>1.01E+4n/an/an/an/an/an/a



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249402
PNG
(US9434697, 116)
Show SMILES COCCN(C(=O)Nc1c(Cl)c(OC)cc(OC)c1Cl)c1cc(Nc2ccccc2NC(=O)C=C)ncn1
Show InChI InChI=1S/C25H26Cl2N6O5/c1-5-21(34)31-16-9-7-6-8-15(16)30-19-13-20(29-14-28-19)33(10-11-36-2)25(35)32-24-22(26)17(37-3)12-18(38-4)23(24)27/h5-9,12-14H,1,10-11H2,2-4H3,(H,31,34)(H,32,35)(H,28,29,30)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249420
PNG
(US9434697, 139)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2cc(OC)cc(OC)c2)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H36N8O4/c1-6-28(38)34-25-16-21(37-12-10-36(7-2)11-13-37)8-9-24(25)33-26-18-27(31-19-30-26)35(3)29(39)32-20-14-22(40-4)17-23(15-20)41-5/h6,8-9,14-19H,1,7,10-13H2,2-5H3,(H,32,39)(H,34,38)(H,30,31,33)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249421
PNG
(US9434697, 140)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)cccc2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C27H30Cl2N8O2/c1-4-25(38)33-22-15-18(37-13-11-36(5-2)12-14-37)9-10-21(22)32-23-16-24(31-17-30-23)35(3)27(39)34-26-19(28)7-6-8-20(26)29/h4,6-10,15-17H,1,5,11-14H2,2-3H3,(H,33,38)(H,34,39)(H,30,31,32)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249422
PNG
(US9434697, 141)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2cc(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H35ClN8O4/c1-6-27(39)34-22-14-19(38-12-10-37(7-2)11-13-38)8-9-21(22)33-25-17-26(32-18-31-25)36(3)29(40)35-23-15-20(41-4)16-24(42-5)28(23)30/h6,8-9,14-18H,1,7,10-13H2,2-5H3,(H,34,39)(H,35,40)(H,31,32,33)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM249397
PNG
(US9434697, 110)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C(F)=C)ncn2)c1Cl
Show InChI InChI=1S/C23H21Cl2FN6O4/c1-12(26)22(33)30-14-8-6-5-7-13(14)29-17-10-18(28-11-27-17)32(2)23(34)31-21-19(24)15(35-3)9-16(36-4)20(21)25/h5-11H,1H2,2-4H3,(H,30,33)(H,31,34)(H,27,28,29)
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n/an/a>5.00E+4n/an/an/an/an/an/a



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%