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Patent code US9434725

Compile Data Set for Download or QSAR

Found 762 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM248989
PNG
(US9434725, 220)
Show SMILES Cc1cncc(n1)-c1cc2n(ncc2cn1)-c1ccc(c(n1)N1CCC[C@H](N)C1)C(F)(F)F
Show InChI InChI=1S/C22H21F3N8/c1-13-8-27-11-18(30-13)17-7-19-14(9-28-17)10-29-33(19)20-5-4-16(22(23,24)25)21(31-20)32-6-2-3-15(26)12-32/h4-5,7-11,15H,2-3,6,12,26H2,1H3/t15-/m0/s1
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0.00900n/an/an/an/an/an/an/an/a



F. HOFFMANN-LA ROCHE AG

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM248978
PNG
(US9434725, 209)
Show SMILES Cc1nc(cnc1N)-c1cc2n(ncc2cn1)-c1cccc(n1)N1CCC[C@H](N)C1
Show InChI InChI=1S/C21H23N9/c1-13-21(23)25-11-17(27-13)16-8-18-14(9-24-16)10-26-30(18)20-6-2-5-19(28-20)29-7-3-4-15(22)12-29/h2,5-6,8-11,15H,3-4,7,12,22H2,1H3,(H2,23,25)/t15-/m0/s1
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F. HOFFMANN-LA ROCHE AG

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM248984
PNG
(US9434725, 215)
Show SMILES Cc1cncc(n1)-c1cc2n(ncc2cn1)-c1ccc(F)c(n1)N1CCC[C@H](N)C1
Show InChI InChI=1S/C21H21FN8/c1-13-8-24-11-18(27-13)17-7-19-14(9-25-17)10-26-30(19)20-5-4-16(22)21(28-20)29-6-2-3-15(23)12-29/h4-5,7-11,15H,2-3,6,12,23H2,1H3/t15-/m0/s1
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F. HOFFMANN-LA ROCHE AG

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM248977
PNG
(US9434725, 208)
Show SMILES Cc1nc(cnc1N)-c1cc2n(ncc2cn1)-c1cccc(n1)N1CCCNCC1
Show InChI InChI=1S/C21H23N9/c1-14-21(22)25-13-17(27-14)16-10-18-15(11-24-16)12-26-30(18)20-5-2-4-19(28-20)29-8-3-6-23-7-9-29/h2,4-5,10-13,23H,3,6-9H2,1H3,(H2,22,25)
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F. HOFFMANN-LA ROCHE AG

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM248955
PNG
(US9434725, 186)
Show SMILES COc1ccc(nc1N1CCC[C@H](N)C1)-n1ncc2cnc(cc12)-c1cncc(C)n1
Show InChI InChI=1S/C22H24N8O/c1-14-9-24-12-18(27-14)17-8-19-15(10-25-17)11-26-30(19)21-6-5-20(31-2)22(28-21)29-7-3-4-16(23)13-29/h5-6,8-12,16H,3-4,7,13,23H2,1-2H3/t16-/m0/s1
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0.0130n/an/an/an/an/an/an/an/a



F. HOFFMANN-LA ROCHE AG

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM248977
PNG
(US9434725, 208)
Show SMILES Cc1nc(cnc1N)-c1cc2n(ncc2cn1)-c1cccc(n1)N1CCCNCC1
Show InChI InChI=1S/C21H23N9/c1-14-21(22)25-13-17(27-14)16-10-18-15(11-24-16)12-26-30(18)20-5-2-4-19(28-20)29-8-3-6-23-7-9-29/h2,4-5,10-13,23H,3,6-9H2,1H3,(H2,22,25)
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F. HOFFMANN-LA ROCHE AG

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM248950
PNG
(US9434725, 181)
Show SMILES Cc1cncc(n1)-c1cc2n(ncc2cn1)-c1ccc(C2CC2)c(n1)N1CCC[C@H](N)C1
Show InChI InChI=1S/C24H26N8/c1-15-10-26-13-21(29-15)20-9-22-17(11-27-20)12-28-32(22)23-7-6-19(16-4-5-16)24(30-23)31-8-2-3-18(25)14-31/h6-7,9-13,16,18H,2-5,8,14,25H2,1H3/t18-/m0/s1
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F. HOFFMANN-LA ROCHE AG

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM248974
PNG
(US9434725, 205)
Show SMILES Cc1cncc(n1)-c1cc2n(ncc2cn1)-c1ccc(C)c(n1)N1CCC[C@H](N)C1
Show InChI InChI=1S/C22H24N8/c1-14-5-6-21(28-22(14)29-7-3-4-17(23)13-29)30-20-8-18(25-10-16(20)11-26-30)19-12-24-9-15(2)27-19/h5-6,8-12,17H,3-4,7,13,23H2,1-2H3/t17-/m0/s1
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F. HOFFMANN-LA ROCHE AG

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Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM248925
PNG
(US9434725, 156)
Show SMILES CCc1cncc(n1)-c1cc2n(ncc2cn1)-c1cccc(n1)N1CCC[C@H](N)C1
Show InChI InChI=1S/C22H24N8/c1-2-17-12-24-13-19(27-17)18-9-20-15(10-25-18)11-26-30(20)22-7-3-6-21(28-22)29-8-4-5-16(23)14-29/h3,6-7,9-13,16H,2,4-5,8,14,23H2,1H3/t16-/m0/s1
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F. HOFFMANN-LA ROCHE AG

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM248940
PNG
(US9434725, 171 | US9434725, 182 | US9434725, 183)
Show SMILES CC1CCC(N)CN1c1cccc(n1)-n1ncc2cnc(cc12)-c1cncc(C)n1
Show InChI InChI=1S/C22H24N8/c1-14-9-24-12-19(27-14)18-8-20-16(10-25-18)11-26-30(20)22-5-3-4-21(28-22)29-13-17(23)7-6-15(29)2/h3-5,8-12,15,17H,6-7,13,23H2,1-2H3
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F. HOFFMANN-LA ROCHE AG

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM249070
PNG
(US9434725, 301)
Show SMILES OCCCc1cncc(n1)-c1cc2n(ncc2cn1)-c1cccc(n1)N1CCNCC1
Show InChI InChI=1S/C22H24N8O/c31-10-2-3-17-14-24-15-19(27-17)18-11-20-16(12-25-18)13-26-30(20)22-5-1-4-21(28-22)29-8-6-23-7-9-29/h1,4-5,11-15,23,31H,2-3,6-10H2
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F. HOFFMANN-LA ROCHE AG

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM248974
PNG
(US9434725, 205)
Show SMILES Cc1cncc(n1)-c1cc2n(ncc2cn1)-c1ccc(C)c(n1)N1CCC[C@H](N)C1
Show InChI InChI=1S/C22H24N8/c1-14-5-6-21(28-22(14)29-7-3-4-17(23)13-29)30-20-8-18(25-10-16(20)11-26-30)19-12-24-9-15(2)27-19/h5-6,8-12,17H,3-4,7,13,23H2,1-2H3/t17-/m0/s1
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F. HOFFMANN-LA ROCHE AG

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM248996
PNG
(US9434725, 227)
Show SMILES Cc1cncc(n1)-c1cc2n(ncc2cn1)-c1ccc(C(F)F)c(n1)N1CCC[C@H](N)C1
Show InChI InChI=1S/C22H22F2N8/c1-13-8-26-11-18(29-13)17-7-19-14(9-27-17)10-28-32(19)20-5-4-16(21(23)24)22(30-20)31-6-2-3-15(25)12-31/h4-5,7-11,15,21H,2-3,6,12,25H2,1H3/t15-/m0/s1
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F. HOFFMANN-LA ROCHE AG

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM248950
PNG
(US9434725, 181)
Show SMILES Cc1cncc(n1)-c1cc2n(ncc2cn1)-c1ccc(C2CC2)c(n1)N1CCC[C@H](N)C1
Show InChI InChI=1S/C24H26N8/c1-15-10-26-13-21(29-15)20-9-22-17(11-27-20)12-28-32(22)23-7-6-19(16-4-5-16)24(30-23)31-8-2-3-18(25)14-31/h6-7,9-13,16,18H,2-5,8,14,25H2,1H3/t18-/m0/s1
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F. HOFFMANN-LA ROCHE AG

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM248919
PNG
(US9434725, 150)
Show SMILES CCc1cncc(n1)-c1cc2n(ncc2cn1)-c1cccc(n1)N1CCCNCC1
Show InChI InChI=1S/C22H24N8/c1-2-17-14-24-15-19(27-17)18-11-20-16(12-25-18)13-26-30(20)22-6-3-5-21(28-22)29-9-4-7-23-8-10-29/h3,5-6,11-15,23H,2,4,7-10H2,1H3
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F. HOFFMANN-LA ROCHE AG

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM248907
PNG
(US9434725, 138)
Show SMILES Cc1cncc(n1)-c1cc2n(ncc2cn1)-c1cccc(n1)N1CCCNCC1
Show InChI InChI=1S/C21H22N8/c1-15-11-23-14-18(26-15)17-10-19-16(12-24-17)13-25-29(19)21-5-2-4-20(27-21)28-8-3-6-22-7-9-28/h2,4-5,10-14,22H,3,6-9H2,1H3
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F. HOFFMANN-LA ROCHE AG

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM249053
PNG
(US9434725, 284)
Show SMILES C1CN(C1)c1cncc(n1)-c1cc2n(ncc2cn1)-c1cccc(n1)N1CCNCC1
Show InChI InChI=1S/C22H23N9/c1-3-20(30-9-5-23-6-10-30)28-21(4-1)31-19-11-17(25-12-16(19)13-26-31)18-14-24-15-22(27-18)29-7-2-8-29/h1,3-4,11-15,23H,2,5-10H2
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F. HOFFMANN-LA ROCHE AG

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM248970
PNG
(US9434725, 201)
Show SMILES Cc1cncc(n1)-c1cc2n(ncc2cn1)-c1ccc(C#N)c(n1)N1CCC[C@H](N)C1
Show InChI InChI=1S/C22H21N9/c1-14-9-25-12-19(28-14)18-7-20-16(10-26-18)11-27-31(20)21-5-4-15(8-23)22(29-21)30-6-2-3-17(24)13-30/h4-5,7,9-12,17H,2-3,6,13,24H2,1H3/t17-/m0/s1
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F. HOFFMANN-LA ROCHE AG

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM248907
PNG
(US9434725, 138)
Show SMILES Cc1cncc(n1)-c1cc2n(ncc2cn1)-c1cccc(n1)N1CCCNCC1
Show InChI InChI=1S/C21H22N8/c1-15-11-23-14-18(26-15)17-10-19-16(12-24-17)13-25-29(19)21-5-2-4-20(27-21)28-8-3-6-22-7-9-28/h2,4-5,10-14,22H,3,6-9H2,1H3
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F. HOFFMANN-LA ROCHE AG

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM248919
PNG
(US9434725, 150)
Show SMILES CCc1cncc(n1)-c1cc2n(ncc2cn1)-c1cccc(n1)N1CCCNCC1
Show InChI InChI=1S/C22H24N8/c1-2-17-14-24-15-19(27-17)18-11-20-16(12-25-18)13-26-30(20)22-6-3-5-21(28-22)29-9-4-7-23-8-10-29/h3,5-6,11-15,23H,2,4,7-10H2,1H3
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F. HOFFMANN-LA ROCHE AG

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM249051
PNG
(US9434725, 282)
Show SMILES OCCNc1cncc(n1)-c1cc2n(ncc2cn1)-c1cccc(n1)N1CCNCC1
Show InChI InChI=1S/C21H23N9O/c31-9-6-24-19-14-23-13-17(27-19)16-10-18-15(11-25-16)12-26-30(18)21-3-1-2-20(28-21)29-7-4-22-5-8-29/h1-3,10-14,22,31H,4-9H2,(H,24,27)
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F. HOFFMANN-LA ROCHE AG

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM248955
PNG
(US9434725, 186)
Show SMILES COc1ccc(nc1N1CCC[C@H](N)C1)-n1ncc2cnc(cc12)-c1cncc(C)n1
Show InChI InChI=1S/C22H24N8O/c1-14-9-24-12-18(27-14)17-8-19-15(10-25-17)11-26-30(19)21-6-5-20(31-2)22(28-21)29-7-3-4-16(23)13-29/h5-6,8-12,16H,3-4,7,13,23H2,1-2H3/t16-/m0/s1
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0.0212n/an/an/an/an/an/an/an/a



F. HOFFMANN-LA ROCHE AG

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM248938
PNG
(US9434725, 169 | US9434725, 185 | US9434725, 193)
Show SMILES CC1CN(CCN1)c1cccc(n1)-n1ncc2cnc(cc12)-c1cncc(C)n1
Show InChI InChI=1S/C21H22N8/c1-14-9-22-12-18(26-14)17-8-19-16(10-24-17)11-25-29(19)21-5-3-4-20(27-21)28-7-6-23-15(2)13-28/h3-5,8-12,15,23H,6-7,13H2,1-2H3
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F. HOFFMANN-LA ROCHE AG

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM249016
PNG
(US9434725, 247)
Show SMILES Nc1cncc(n1)-c1cc2n(ncc2cn1)-c1cccc(n1)N1CCCNCC1
Show InChI InChI=1S/C20H21N9/c21-18-13-23-12-16(26-18)15-9-17-14(10-24-15)11-25-29(17)20-4-1-3-19(27-20)28-7-2-5-22-6-8-28/h1,3-4,9-13,22H,2,5-8H2,(H2,21,26)
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F. HOFFMANN-LA ROCHE AG

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM248959
PNG
(US9434725, 190)
Show SMILES Cc1cncc(n1)-c1cc2n(ncc2cn1)-c1cccc(NC2CCNCC2)n1
Show InChI InChI=1S/C21H22N8/c1-14-10-23-13-18(26-14)17-9-19-15(11-24-17)12-25-29(19)21-4-2-3-20(28-21)27-16-5-7-22-8-6-16/h2-4,9-13,16,22H,5-8H2,1H3,(H,27,28)
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F. HOFFMANN-LA ROCHE AG

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM249028
PNG
(US9434725, 259 | US9434725, 271 | US9434725, 272)
Show SMILES Cc1cncc(n1)-c1cc2n(ncc2cn1)-c1cccc(n1)C1CNCCC1(F)F
Show InChI InChI=1S/C21H19F2N7/c1-13-8-25-12-18(28-13)17-7-19-14(9-26-17)10-27-30(19)20-4-2-3-16(29-20)15-11-24-6-5-21(15,22)23/h2-4,7-10,12,15,24H,5-6,11H2,1H3
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0.0235n/an/an/an/an/an/an/an/a



F. HOFFMANN-LA ROCHE AG

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM249053
PNG
(US9434725, 284)
Show SMILES C1CN(C1)c1cncc(n1)-c1cc2n(ncc2cn1)-c1cccc(n1)N1CCNCC1
Show InChI InChI=1S/C22H23N9/c1-3-20(30-9-5-23-6-10-30)28-21(4-1)31-19-11-17(25-12-16(19)13-26-31)18-14-24-15-22(27-18)29-7-2-8-29/h1,3-4,11-15,23H,2,5-10H2
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0.0250n/an/an/an/an/an/an/an/a



F. HOFFMANN-LA ROCHE AG

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM248964
PNG
(US9434725, 195 | US9434725, 203 | US9434725, 204)
Show SMILES CC1C(N)CCCN1c1cccc(n1)-n1ncc2cnc(cc12)-c1cncc(C)n1
Show InChI InChI=1S/C22H24N8/c1-14-10-24-13-19(27-14)18-9-20-16(11-25-18)12-26-30(20)22-7-3-6-21(28-22)29-8-4-5-17(23)15(29)2/h3,6-7,9-13,15,17H,4-5,8,23H2,1-2H3
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F. HOFFMANN-LA ROCHE AG

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM249028
PNG
(US9434725, 259 | US9434725, 271 | US9434725, 272)
Show SMILES Cc1cncc(n1)-c1cc2n(ncc2cn1)-c1cccc(n1)C1CNCCC1(F)F
Show InChI InChI=1S/C21H19F2N7/c1-13-8-25-12-18(28-13)17-7-19-14(9-26-17)10-27-30(19)20-4-2-3-16(29-20)15-11-24-6-5-21(15,22)23/h2-4,7-10,12,15,24H,5-6,11H2,1H3
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F. HOFFMANN-LA ROCHE AG

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM249007
PNG
(US9434725, 238)
Show SMILES Cc1cncc(n1)-c1cc2n(ncc2cn1)-c1cnc(C2CC2)c(n1)N1CCC[C@H](N)C1
Show InChI InChI=1S/C23H25N9/c1-14-8-25-11-19(29-14)18-7-20-16(9-26-18)10-28-32(20)21-12-27-22(15-4-5-15)23(30-21)31-6-2-3-17(24)13-31/h7-12,15,17H,2-6,13,24H2,1H3/t17-/m0/s1
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F. HOFFMANN-LA ROCHE AG

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM249086
PNG
(US9434725, 317)
Show SMILES CC#Cc1cncc(n1)-c1cc2n(ncc2cn1)-c1cccc(n1)N1CCNCC1
Show InChI InChI=1S/C22H20N8/c1-2-4-17-14-24-15-19(27-17)18-11-20-16(12-25-18)13-26-30(20)22-6-3-5-21(28-22)29-9-7-23-8-10-29/h3,5-6,11-15,23H,7-10H2,1H3
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F. HOFFMANN-LA ROCHE AG

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM249051
PNG
(US9434725, 282)
Show SMILES OCCNc1cncc(n1)-c1cc2n(ncc2cn1)-c1cccc(n1)N1CCNCC1
Show InChI InChI=1S/C21H23N9O/c31-9-6-24-19-14-23-13-17(27-19)16-10-18-15(11-25-16)12-26-30(18)21-3-1-2-20(28-21)29-7-4-22-5-8-29/h1-3,10-14,22,31H,4-9H2,(H,24,27)
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F. HOFFMANN-LA ROCHE AG

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM249016
PNG
(US9434725, 247)
Show SMILES Nc1cncc(n1)-c1cc2n(ncc2cn1)-c1cccc(n1)N1CCCNCC1
Show InChI InChI=1S/C20H21N9/c21-18-13-23-12-16(26-18)15-9-17-14(10-24-15)11-25-29(17)20-4-1-3-19(27-20)28-7-2-5-22-6-8-28/h1,3-4,9-13,22H,2,5-8H2,(H2,21,26)
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F. HOFFMANN-LA ROCHE AG

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM248940
PNG
(US9434725, 171 | US9434725, 182 | US9434725, 183)
Show SMILES CC1CCC(N)CN1c1cccc(n1)-n1ncc2cnc(cc12)-c1cncc(C)n1
Show InChI InChI=1S/C22H24N8/c1-14-9-24-12-19(27-14)18-8-20-16(10-25-18)11-26-30(20)22-5-3-4-21(28-22)29-13-17(23)7-6-15(29)2/h3-5,8-12,15,17H,6-7,13,23H2,1-2H3
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0.0280n/an/an/an/an/an/an/an/a



F. HOFFMANN-LA ROCHE AG

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM248940
PNG
(US9434725, 171 | US9434725, 182 | US9434725, 183)
Show SMILES CC1CCC(N)CN1c1cccc(n1)-n1ncc2cnc(cc12)-c1cncc(C)n1
Show InChI InChI=1S/C22H24N8/c1-14-9-24-12-19(27-14)18-8-20-16(10-25-18)11-26-30(20)22-5-3-4-21(28-22)29-13-17(23)7-6-15(29)2/h3-5,8-12,15,17H,6-7,13,23H2,1-2H3
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F. HOFFMANN-LA ROCHE AG

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM248940
PNG
(US9434725, 171 | US9434725, 182 | US9434725, 183)
Show SMILES CC1CCC(N)CN1c1cccc(n1)-n1ncc2cnc(cc12)-c1cncc(C)n1
Show InChI InChI=1S/C22H24N8/c1-14-9-24-12-19(27-14)18-8-20-16(10-25-18)11-26-30(20)22-5-3-4-21(28-22)29-13-17(23)7-6-15(29)2/h3-5,8-12,15,17H,6-7,13,23H2,1-2H3
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F. HOFFMANN-LA ROCHE AG

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM248998
PNG
(US9434725, 229 | US9434725, 231)
Show SMILES Cn1cc(cn1)-c1cc2n(ncc2cn1)-c1cccc(n1)N1CCNCC(O)C1
Show InChI InChI=1S/C20H22N8O/c1-26-12-15(10-23-26)17-7-18-14(8-22-17)9-24-28(18)20-4-2-3-19(25-20)27-6-5-21-11-16(29)13-27/h2-4,7-10,12,16,21,29H,5-6,11,13H2,1H3
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F. HOFFMANN-LA ROCHE AG

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM248940
PNG
(US9434725, 171 | US9434725, 182 | US9434725, 183)
Show SMILES CC1CCC(N)CN1c1cccc(n1)-n1ncc2cnc(cc12)-c1cncc(C)n1
Show InChI InChI=1S/C22H24N8/c1-14-9-24-12-19(27-14)18-8-20-16(10-25-18)11-26-30(20)22-5-3-4-21(28-22)29-13-17(23)7-6-15(29)2/h3-5,8-12,15,17H,6-7,13,23H2,1-2H3
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F. HOFFMANN-LA ROCHE AG

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM249069
PNG
(US9434725, 300)
Show SMILES OCC#Cc1cncc(n1)-c1cc2n(ncc2cn1)-c1cccc(n1)N1CCNCC1
Show InChI InChI=1S/C22H20N8O/c31-10-2-3-17-14-24-15-19(27-17)18-11-20-16(12-25-18)13-26-30(20)22-5-1-4-21(28-22)29-8-6-23-7-9-29/h1,4-5,11-15,23,31H,6-10H2
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F. HOFFMANN-LA ROCHE AG

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM248872
PNG
(US9434725, 103)
Show SMILES CC(C)c1cncc(c1)-c1cc2n(ncc2cn1)-c1cccc(n1)N1CCCNCC1
Show InChI InChI=1S/C24H27N7/c1-17(2)18-11-19(14-26-13-18)21-12-22-20(15-27-21)16-28-31(22)24-6-3-5-23(29-24)30-9-4-7-25-8-10-30/h3,5-6,11-17,25H,4,7-10H2,1-2H3
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F. HOFFMANN-LA ROCHE AG

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM249007
PNG
(US9434725, 238)
Show SMILES Cc1cncc(n1)-c1cc2n(ncc2cn1)-c1cnc(C2CC2)c(n1)N1CCC[C@H](N)C1
Show InChI InChI=1S/C23H25N9/c1-14-8-25-11-19(29-14)18-7-20-16(9-26-18)10-28-32(20)21-12-27-22(15-4-5-15)23(30-21)31-6-2-3-17(24)13-31/h7-12,15,17H,2-6,13,24H2,1H3/t17-/m0/s1
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F. HOFFMANN-LA ROCHE AG

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM248960
PNG
(US9434725, 191)
Show SMILES C[C@@H]1CNCCN1c1cccc(n1)-n1ncc2cnc(cc12)-c1cncc(C)n1
Show InChI InChI=1S/C21H22N8/c1-14-9-23-13-18(26-14)17-8-19-16(11-24-17)12-25-29(19)21-5-3-4-20(27-21)28-7-6-22-10-15(28)2/h3-5,8-9,11-13,15,22H,6-7,10H2,1-2H3/t15-/m1/s1
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F. HOFFMANN-LA ROCHE AG

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM248908
PNG
(US9434725, 139)
Show SMILES CCc1cncc(c1)-c1cc2n(ncc2cn1)-c1ccc(C2CC2)c(n1)N1CCC[C@H](N)C1
Show InChI InChI=1S/C26H29N7/c1-2-17-10-19(13-28-12-17)23-11-24-20(14-29-23)15-30-33(24)25-8-7-22(18-5-6-18)26(31-25)32-9-3-4-21(27)16-32/h7-8,10-15,18,21H,2-6,9,16,27H2,1H3/t21-/m0/s1
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F. HOFFMANN-LA ROCHE AG

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM249070
PNG
(US9434725, 301)
Show SMILES OCCCc1cncc(n1)-c1cc2n(ncc2cn1)-c1cccc(n1)N1CCNCC1
Show InChI InChI=1S/C22H24N8O/c31-10-2-3-17-14-24-15-19(27-17)18-11-20-16(12-25-18)13-26-30(20)22-5-1-4-21(28-22)29-8-6-23-7-9-29/h1,4-5,11-15,23,31H,2-3,6-10H2
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F. HOFFMANN-LA ROCHE AG

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM248941
PNG
(US9434725, 172)
Show SMILES CCc1cncc(n1)-c1cc2n(ncc2cn1)-c1cccc(n1)N1CCNCC(O)C1
Show InChI InChI=1S/C22H24N8O/c1-2-16-11-24-13-19(27-16)18-8-20-15(9-25-18)10-26-30(20)22-5-3-4-21(28-22)29-7-6-23-12-17(31)14-29/h3-5,8-11,13,17,23,31H,2,6-7,12,14H2,1H3
PDB

UniProtKB/SwissProt

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PC sid
UniChem
US Patent
0.0340n/an/an/an/an/an/an/an/a



F. HOFFMANN-LA ROCHE AG

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM248989
PNG
(US9434725, 220)
Show SMILES Cc1cncc(n1)-c1cc2n(ncc2cn1)-c1ccc(c(n1)N1CCC[C@H](N)C1)C(F)(F)F
Show InChI InChI=1S/C22H21F3N8/c1-13-8-27-11-18(30-13)17-7-19-14(9-28-17)10-29-33(19)20-5-4-16(22(23,24)25)21(31-20)32-6-2-3-15(26)12-32/h4-5,7-11,15H,2-3,6,12,26H2,1H3/t15-/m0/s1
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UniChem
US Patent
0.0340n/an/an/an/an/an/an/an/a



F. HOFFMANN-LA ROCHE AG

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM248964
PNG
(US9434725, 195 | US9434725, 203 | US9434725, 204)
Show SMILES CC1C(N)CCCN1c1cccc(n1)-n1ncc2cnc(cc12)-c1cncc(C)n1
Show InChI InChI=1S/C22H24N8/c1-14-10-24-13-19(27-14)18-9-20-16(11-25-18)12-26-30(20)22-7-3-6-21(28-22)29-8-4-5-17(23)15(29)2/h3,6-7,9-13,15,17H,4-5,8,23H2,1-2H3
PDB

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PC cid
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US Patent
0.0340n/an/an/an/an/an/an/an/a



F. HOFFMANN-LA ROCHE AG

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM248938
PNG
(US9434725, 169 | US9434725, 185 | US9434725, 193)
Show SMILES CC1CN(CCN1)c1cccc(n1)-n1ncc2cnc(cc12)-c1cncc(C)n1
Show InChI InChI=1S/C21H22N8/c1-14-9-22-12-18(26-14)17-8-19-16(10-24-17)11-25-29(19)21-5-3-4-20(27-21)28-7-6-23-15(2)13-28/h3-5,8-12,15,23H,6-7,13H2,1-2H3
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0.0350n/an/an/an/an/an/an/an/a



F. HOFFMANN-LA ROCHE AG

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM248979
PNG
(US9434725, 210 | US9434725, 211 | US9434725, 212 |...)
Show SMILES Cc1cncc(n1)-c1cc2n(ncc2cn1)-c1cccc(n1)C1CCCC(N)C1
Show InChI InChI=1S/C22H23N7/c1-14-10-24-13-20(27-14)19-9-21-16(11-25-19)12-26-29(21)22-7-3-6-18(28-22)15-4-2-5-17(23)8-15/h3,6-7,9-13,15,17H,2,4-5,8,23H2,1H3
KEGG

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PC sid
UniChem
US Patent
0.0350n/an/an/an/an/an/an/an/a



F. HOFFMANN-LA ROCHE AG

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM248940
PNG
(US9434725, 171 | US9434725, 182 | US9434725, 183)
Show SMILES CC1CCC(N)CN1c1cccc(n1)-n1ncc2cnc(cc12)-c1cncc(C)n1
Show InChI InChI=1S/C22H24N8/c1-14-9-24-12-19(27-14)18-8-20-16(10-25-18)11-26-30(20)22-5-3-4-21(28-22)29-13-17(23)7-6-15(29)2/h3-5,8-12,15,17H,6-7,13,23H2,1-2H3
KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
0.0350n/an/an/an/an/an/an/an/a



F. HOFFMANN-LA ROCHE AG

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


Citation and Details
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%