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Patent code US9446044

Compile Data Set for Download or QSAR
Found 107 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM50434358
PNG
(CHEMBL2386770 | US9446044, 68)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc(F)cc4Br)c3c2s1
Show InChI InChI=1S/C17H11BrFN5OS/c1-25-15(20)17-24-12-5-4-11-13(14(12)26-17)16(22-7-21-11)23-10-3-2-8(19)6-9(10)18/h2-7,20H,1H3,(H,21,22,23)
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n/an/a 0.160n/an/an/an/an/an/a



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US Patent


Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM50434353
PNG
(CHEMBL2386747 | US9446044, 72)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc(Cl)cc4Cl)c3c2s1
Show InChI InChI=1S/C17H11Cl2N5OS/c1-25-15(20)17-24-12-5-4-11-13(14(12)26-17)16(22-7-21-11)23-10-3-2-8(18)6-9(10)19/h2-7,20H,1H3,(H,21,22,23)
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US Patent


Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-regulated kinases 1B


(Homo sapiens (Human))
BDBM50434358
PNG
(CHEMBL2386770 | US9446044, 68)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc(F)cc4Br)c3c2s1
Show InChI InChI=1S/C17H11BrFN5OS/c1-25-15(20)17-24-12-5-4-11-13(14(12)26-17)16(22-7-21-11)23-10-3-2-8(19)6-9(10)18/h2-7,20H,1H3,(H,21,22,23)
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Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-regulated kinases 1B


(Homo sapiens (Human))
BDBM50434353
PNG
(CHEMBL2386747 | US9446044, 72)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc(Cl)cc4Cl)c3c2s1
Show InChI InChI=1S/C17H11Cl2N5OS/c1-25-15(20)17-24-12-5-4-11-13(14(12)26-17)16(22-7-21-11)23-10-3-2-8(18)6-9(10)19/h2-7,20H,1H3,(H,21,22,23)
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US Patent


Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM246383
PNG
(US9446044, 69)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc(OC)cc4F)c3c2s1
Show InChI InChI=1S/C18H14FN5O2S/c1-25-9-3-4-11(10(19)7-9)23-17-14-12(21-8-22-17)5-6-13-15(14)27-18(24-13)16(20)26-2/h3-8,20H,1-2H3,(H,21,22,23)
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US Patent


Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-regulated kinases 1B


(Homo sapiens (Human))
BDBM246383
PNG
(US9446044, 69)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc(OC)cc4F)c3c2s1
Show InChI InChI=1S/C18H14FN5O2S/c1-25-9-3-4-11(10(19)7-9)23-17-14-12(21-8-22-17)5-6-13-15(14)27-18(24-13)16(20)26-2/h3-8,20H,1-2H3,(H,21,22,23)
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Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM50434352
PNG
(CHEMBL2386748 | US9446044, 78)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc(F)cc4F)c3c2s1
Show InChI InChI=1S/C17H11F2N5OS/c1-25-15(20)17-24-12-5-4-11-13(14(12)26-17)16(22-7-21-11)23-10-3-2-8(18)6-9(10)19/h2-7,20H,1H3,(H,21,22,23)
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Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM50434364
PNG
(CHEMBL2386764 | US9446044, 65)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc(C)cc4)c3c2s1
Show InChI InChI=1S/C18H15N5OS/c1-10-3-5-11(6-4-10)22-17-14-12(20-9-21-17)7-8-13-15(14)25-18(23-13)16(19)24-2/h3-9,19H,1-2H3,(H,20,21,22)
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Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM246384
PNG
(US9446044, 71)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc(Cl)cc4F)c3c2s1
Show InChI InChI=1S/C17H11ClFN5OS/c1-25-15(20)17-24-12-5-4-11-13(14(12)26-17)16(22-7-21-11)23-10-3-2-8(18)6-9(10)19/h2-7,20H,1H3,(H,21,22,23)
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Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-regulated kinases 1B


(Homo sapiens (Human))
BDBM50434352
PNG
(CHEMBL2386748 | US9446044, 78)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc(F)cc4F)c3c2s1
Show InChI InChI=1S/C17H11F2N5OS/c1-25-15(20)17-24-12-5-4-11-13(14(12)26-17)16(22-7-21-11)23-10-3-2-8(18)6-9(10)19/h2-7,20H,1H3,(H,21,22,23)
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US Patent


Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM50434338
PNG
(CHEMBL2386762 | US9446044, 56)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc(Cl)cc4)c3c2s1
Show InChI InChI=1S/C17H12ClN5OS/c1-24-15(19)17-23-12-7-6-11-13(14(12)25-17)16(21-8-20-11)22-10-4-2-9(18)3-5-10/h2-8,19H,1H3,(H,20,21,22)
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US Patent


Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-regulated kinases 1B


(Homo sapiens (Human))
BDBM246384
PNG
(US9446044, 71)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc(Cl)cc4F)c3c2s1
Show InChI InChI=1S/C17H11ClFN5OS/c1-25-15(20)17-24-12-5-4-11-13(14(12)26-17)16(22-7-21-11)23-10-3-2-8(18)6-9(10)19/h2-7,20H,1H3,(H,21,22,23)
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US Patent


Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM50434347
PNG
(CHEMBL2386753 | US9446044, 48)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc5OCOc5c4)c3c2s1
Show InChI InChI=1S/C18H13N5O3S/c1-24-16(19)18-23-11-4-3-10-14(15(11)27-18)17(21-7-20-10)22-9-2-5-12-13(6-9)26-8-25-12/h2-7,19H,8H2,1H3,(H,20,21,22)
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Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM50434365
PNG
(CHEMBL2386763 | US9446044, 64)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccccc4)c3c2s1
Show InChI InChI=1S/C17H13N5OS/c1-23-15(18)17-22-12-8-7-11-13(14(12)24-17)16(20-9-19-11)21-10-5-3-2-4-6-10/h2-9,18H,1H3,(H,19,20,21)
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Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM246372
PNG
(US9446044, 47)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4cc5OCOc5c(Br)c4)c3c2s1
Show InChI InChI=1S/C18H12BrN5O3S/c1-25-16(20)18-24-11-3-2-10-13(15(11)28-18)17(22-6-21-10)23-8-4-9(19)14-12(5-8)26-7-27-14/h2-6,20H,7H2,1H3,(H,21,22,23)
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US Patent


Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-regulated kinases 1B


(Homo sapiens (Human))
BDBM50434364
PNG
(CHEMBL2386764 | US9446044, 65)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc(C)cc4)c3c2s1
Show InChI InChI=1S/C18H15N5OS/c1-10-3-5-11(6-4-10)22-17-14-12(20-9-21-17)7-8-13-15(14)25-18(23-13)16(19)24-2/h3-9,19H,1-2H3,(H,20,21,22)
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n/an/a 2.83n/an/an/an/an/an/a



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US Patent


Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-regulated kinases 1B


(Homo sapiens (Human))
BDBM50434365
PNG
(CHEMBL2386763 | US9446044, 64)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccccc4)c3c2s1
Show InChI InChI=1S/C17H13N5OS/c1-23-15(18)17-22-12-8-7-11-13(14(12)24-17)16(20-9-19-11)21-10-5-3-2-4-6-10/h2-9,18H,1H3,(H,19,20,21)
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n/an/a 3.48n/an/an/an/an/an/a



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US Patent


Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM50434356
PNG
(CHEMBL2386744 | US9446044, 44)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc(Br)cc4F)c3c2s1
Show InChI InChI=1S/C17H11BrFN5OS/c1-25-15(20)17-24-12-5-4-11-13(14(12)26-17)16(22-7-21-11)23-10-3-2-8(18)6-9(10)19/h2-7,20H,1H3,(H,21,22,23)
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US Patent


Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-regulated kinases 1B


(Homo sapiens (Human))
BDBM246372
PNG
(US9446044, 47)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4cc5OCOc5c(Br)c4)c3c2s1
Show InChI InChI=1S/C18H12BrN5O3S/c1-25-16(20)18-24-11-3-2-10-13(15(11)28-18)17(22-6-21-10)23-8-4-9(19)14-12(5-8)26-7-27-14/h2-6,20H,7H2,1H3,(H,21,22,23)
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US Patent


Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM50434362
PNG
(CHEMBL2386766 | US9446044, 70)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc(cc4)C#N)c3c2s1
Show InChI InChI=1S/C18H12N6OS/c1-25-16(20)18-24-13-7-6-12-14(15(13)26-18)17(22-9-21-12)23-11-4-2-10(8-19)3-5-11/h2-7,9,20H,1H3,(H,21,22,23)
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DIAXONHIT

US Patent


Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-regulated kinases 1B


(Homo sapiens (Human))
BDBM50434347
PNG
(CHEMBL2386753 | US9446044, 48)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc5OCOc5c4)c3c2s1
Show InChI InChI=1S/C18H13N5O3S/c1-24-16(19)18-23-11-4-3-10-14(15(11)27-18)17(21-7-20-10)22-9-2-5-12-13(6-9)26-8-25-12/h2-7,19H,8H2,1H3,(H,20,21,22)
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n/an/a 4.20n/an/an/an/an/an/a



DIAXONHIT

US Patent


Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM246377
PNG
(US9446044, 54)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc(OC)c(O)c4)c3c2s1
Show InChI InChI=1S/C18H15N5O3S/c1-25-13-6-3-9(7-12(13)24)22-17-14-10(20-8-21-17)4-5-11-15(14)27-18(23-11)16(19)26-2/h3-8,19,24H,1-2H3,(H,20,21,22)
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US Patent


Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM246381
PNG
(US9446044, 59)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc5nc[nH]c5c4)c3c2s1
Show InChI InChI=1S/C18H13N7OS/c1-26-16(19)18-25-12-5-4-11-14(15(12)27-18)17(23-8-21-11)24-9-2-3-10-13(6-9)22-7-20-10/h2-8,19H,1H3,(H,20,22)(H,21,23,24)
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The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


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More data for this
Ligand-Target Pair
Dual-specificity tyrosine-regulated kinases 1B


(Homo sapiens (Human))
BDBM246381
PNG
(US9446044, 59)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc5nc[nH]c5c4)c3c2s1
Show InChI InChI=1S/C18H13N7OS/c1-26-16(19)18-25-12-5-4-11-14(15(12)27-18)17(23-8-21-11)24-9-2-3-10-13(6-9)22-7-20-10/h2-8,19H,1H3,(H,20,22)(H,21,23,24)
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The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


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More data for this
Ligand-Target Pair
Dual-specificity tyrosine-regulated kinases 1B


(Homo sapiens (Human))
BDBM50434338
PNG
(CHEMBL2386762 | US9446044, 56)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc(Cl)cc4)c3c2s1
Show InChI InChI=1S/C17H12ClN5OS/c1-24-15(19)17-23-12-7-6-11-13(14(12)25-17)16(21-8-20-11)22-10-4-2-9(18)3-5-10/h2-8,19H,1H3,(H,20,21,22)
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The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


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More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM50434351
PNG
(CHEMBL2386749 | US9446044, 60)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc(O)c(c4)[N+]([O-])=O)c3c2s1
Show InChI InChI=1S/C17H12N6O4S/c1-27-15(18)17-22-10-4-3-9-13(14(10)28-17)16(20-7-19-9)21-8-2-5-12(24)11(6-8)23(25)26/h2-7,18,24H,1H3,(H,19,20,21)
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The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


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More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM50434340
PNG
(CHEMBL2386760 | US9446044, 89)
Show SMILES COC(=O)c1nc2ccc3ncnc(Nc4ccc(Cl)cc4Cl)c3c2s1
Show InChI InChI=1S/C17H10Cl2N4O2S/c1-25-17(24)16-23-12-5-4-11-13(14(12)26-16)15(21-7-20-11)22-10-3-2-8(18)6-9(10)19/h2-7H,1H3,(H,20,21,22)
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The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


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More data for this
Ligand-Target Pair
Dual-specificity tyrosine-regulated kinases 1B


(Homo sapiens (Human))
BDBM50434351
PNG
(CHEMBL2386749 | US9446044, 60)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc(O)c(c4)[N+]([O-])=O)c3c2s1
Show InChI InChI=1S/C17H12N6O4S/c1-27-15(18)17-22-10-4-3-9-13(14(10)28-17)16(20-7-19-9)21-8-2-5-12(24)11(6-8)23(25)26/h2-7,18,24H,1H3,(H,19,20,21)
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The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


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More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM50434346
PNG
(CHEMBL2386754 | US9446044, 82)
Show SMILES CCOC(=N)c1nc2ccc3ncnc(Nc4ccc5OCOc5c4)c3c2s1
Show InChI InChI=1S/C19H15N5O3S/c1-2-25-17(20)19-24-12-5-4-11-15(16(12)28-19)18(22-8-21-11)23-10-3-6-13-14(7-10)27-9-26-13/h3-8,20H,2,9H2,1H3,(H,21,22,23)
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The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


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More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM50434363
PNG
(CHEMBL2386765 | US9446044, 66)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc(F)cc4)c3c2s1
Show InChI InChI=1S/C17H12FN5OS/c1-24-15(19)17-23-12-7-6-11-13(14(12)25-17)16(21-8-20-11)22-10-4-2-9(18)3-5-10/h2-8,19H,1H3,(H,20,21,22)
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The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


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More data for this
Ligand-Target Pair
Dual-specificity tyrosine-regulated kinases 1B


(Homo sapiens (Human))
BDBM50434356
PNG
(CHEMBL2386744 | US9446044, 44)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc(Br)cc4F)c3c2s1
Show InChI InChI=1S/C17H11BrFN5OS/c1-25-15(20)17-24-12-5-4-11-13(14(12)26-17)16(22-7-21-11)23-10-3-2-8(18)6-9(10)19/h2-7,20H,1H3,(H,21,22,23)
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The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


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More data for this
Ligand-Target Pair
Dual-specificity tyrosine-regulated kinases 1B


(Homo sapiens (Human))
BDBM50434362
PNG
(CHEMBL2386766 | US9446044, 70)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc(cc4)C#N)c3c2s1
Show InChI InChI=1S/C18H12N6OS/c1-25-16(20)18-24-13-7-6-12-14(15(13)26-18)17(22-9-21-12)23-11-4-2-10(8-19)3-5-11/h2-7,9,20H,1H3,(H,21,22,23)
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The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


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Ligand-Target Pair
Dual-specificity tyrosine-regulated kinases 1B


(Homo sapiens (Human))
BDBM50434340
PNG
(CHEMBL2386760 | US9446044, 89)
Show SMILES COC(=O)c1nc2ccc3ncnc(Nc4ccc(Cl)cc4Cl)c3c2s1
Show InChI InChI=1S/C17H10Cl2N4O2S/c1-25-17(24)16-23-12-5-4-11-13(14(12)26-16)15(21-7-20-11)22-10-3-2-8(18)6-9(10)19/h2-7H,1H3,(H,20,21,22)
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The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


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More data for this
Ligand-Target Pair
Dual-specificity tyrosine-regulated kinases 1B


(Homo sapiens (Human))
BDBM50434346
PNG
(CHEMBL2386754 | US9446044, 82)
Show SMILES CCOC(=N)c1nc2ccc3ncnc(Nc4ccc5OCOc5c4)c3c2s1
Show InChI InChI=1S/C19H15N5O3S/c1-2-25-17(20)19-24-12-5-4-11-15(16(12)28-19)18(22-8-21-11)23-10-3-6-13-14(7-10)27-9-26-13/h3-8,20H,2,9H2,1H3,(H,21,22,23)
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The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


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More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM246373
PNG
(US9446044, 49)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc5OCCOc5c4)c3c2s1
Show InChI InChI=1S/C19H15N5O3S/c1-25-17(20)19-24-12-4-3-11-15(16(12)28-19)18(22-9-21-11)23-10-2-5-13-14(8-10)27-7-6-26-13/h2-5,8-9,20H,6-7H2,1H3,(H,21,22,23)
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The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


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Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM50434348
PNG
(CHEMBL2386752 | US9446044, 79)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc(O)c(F)c4)c3c2s1
Show InChI InChI=1S/C17H12FN5O2S/c1-25-15(19)17-23-11-4-3-10-13(14(11)26-17)16(21-7-20-10)22-8-2-5-12(24)9(18)6-8/h2-7,19,24H,1H3,(H,20,21,22)
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The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


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More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM50434357
PNG
(CHEMBL2386743 | US9446044, 62)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc(OC)cc4OC)c3c2s1
Show InChI InChI=1S/C19H17N5O3S/c1-25-10-4-5-11(14(8-10)26-2)23-18-15-12(21-9-22-18)6-7-13-16(15)28-19(24-13)17(20)27-3/h4-9,20H,1-3H3,(H,21,22,23)
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The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


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Ligand-Target Pair
Dual-specificity tyrosine-regulated kinases 1B


(Homo sapiens (Human))
BDBM50434363
PNG
(CHEMBL2386765 | US9446044, 66)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc(F)cc4)c3c2s1
Show InChI InChI=1S/C17H12FN5OS/c1-24-15(19)17-23-12-7-6-11-13(14(12)25-17)16(21-8-20-11)22-10-4-2-9(18)3-5-10/h2-8,19H,1H3,(H,20,21,22)
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The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


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More data for this
Ligand-Target Pair
Dual-specificity tyrosine-regulated kinases 1B


(Homo sapiens (Human))
BDBM50434348
PNG
(CHEMBL2386752 | US9446044, 79)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc(O)c(F)c4)c3c2s1
Show InChI InChI=1S/C17H12FN5O2S/c1-25-15(19)17-23-11-4-3-10-13(14(11)26-17)16(21-7-20-10)22-8-2-5-12(24)9(18)6-8/h2-7,19,24H,1H3,(H,20,21,22)
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The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


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Ligand-Target Pair
Dual-specificity tyrosine-regulated kinases 1B


(Homo sapiens (Human))
BDBM50434357
PNG
(CHEMBL2386743 | US9446044, 62)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc(OC)cc4OC)c3c2s1
Show InChI InChI=1S/C19H17N5O3S/c1-25-10-4-5-11(14(8-10)26-2)23-18-15-12(21-9-22-18)6-7-13-16(15)28-19(24-13)17(20)27-3/h4-9,20H,1-3H3,(H,21,22,23)
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The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


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More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM50434339
PNG
(CHEMBL2386761 | US9446044, 45)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc(OC)cc4)c3c2s1
Show InChI InChI=1S/C18H15N5O2S/c1-24-11-5-3-10(4-6-11)22-17-14-12(20-9-21-17)7-8-13-15(14)26-18(23-13)16(19)25-2/h3-9,19H,1-2H3,(H,20,21,22)
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The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


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Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM50434349
PNG
(CHEMBL2386751 | US9446044, 75)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4cccc(Cl)c4)c3c2s1
Show InChI InChI=1S/C17H12ClN5OS/c1-24-15(19)17-23-12-6-5-11-13(14(12)25-17)16(21-8-20-11)22-10-4-2-3-9(18)7-10/h2-8,19H,1H3,(H,20,21,22)
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The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


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Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM246378
PNG
(US9446044, 55)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc5OCCc5c4)c3c2s1
Show InChI InChI=1S/C19H15N5O2S/c1-25-17(20)19-24-13-4-3-12-15(16(13)27-19)18(22-9-21-12)23-11-2-5-14-10(8-11)6-7-26-14/h2-5,8-9,20H,6-7H2,1H3,(H,21,22,23)
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The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


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More data for this
Ligand-Target Pair
Dual-specificity tyrosine-regulated kinases 1B


(Homo sapiens (Human))
BDBM246373
PNG
(US9446044, 49)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc5OCCOc5c4)c3c2s1
Show InChI InChI=1S/C19H15N5O3S/c1-25-17(20)19-24-12-4-3-11-15(16(12)28-19)18(22-9-21-11)23-10-2-5-13-14(8-10)27-7-6-26-13/h2-5,8-9,20H,6-7H2,1H3,(H,21,22,23)
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The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


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Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM50434359
PNG
(CHEMBL2386769 | US9446044, 80)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc(cc4)C(F)(F)F)c3c2s1
Show InChI InChI=1S/C18H12F3N5OS/c1-27-15(22)17-26-12-7-6-11-13(14(12)28-17)16(24-8-23-11)25-10-4-2-9(3-5-10)18(19,20)21/h2-8,22H,1H3,(H,23,24,25)
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Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


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More data for this
Ligand-Target Pair
Dual-specificity tyrosine-regulated kinases 1B


(Homo sapiens (Human))
BDBM50434349
PNG
(CHEMBL2386751 | US9446044, 75)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4cccc(Cl)c4)c3c2s1
Show InChI InChI=1S/C17H12ClN5OS/c1-24-15(19)17-23-12-6-5-11-13(14(12)25-17)16(21-8-20-11)22-10-4-2-3-9(18)7-10/h2-8,19H,1H3,(H,20,21,22)
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DIAXONHIT

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Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-regulated kinases 1B


(Homo sapiens (Human))
BDBM50434339
PNG
(CHEMBL2386761 | US9446044, 45)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc(OC)cc4)c3c2s1
Show InChI InChI=1S/C18H15N5O2S/c1-24-11-5-3-10(4-6-11)22-17-14-12(20-9-21-17)7-8-13-15(14)26-18(23-13)16(19)25-2/h3-9,19H,1-2H3,(H,20,21,22)
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Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-regulated kinases 1B


(Homo sapiens (Human))
BDBM50434359
PNG
(CHEMBL2386769 | US9446044, 80)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc(cc4)C(F)(F)F)c3c2s1
Show InChI InChI=1S/C18H12F3N5OS/c1-27-15(22)17-26-12-7-6-11-13(14(12)28-17)16(24-8-23-11)25-10-4-2-9(3-5-10)18(19,20)21/h2-8,22H,1H3,(H,23,24,25)
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Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM50434341
PNG
(CHEMBL2386759 | US9446044, 86)
Show SMILES NC(=O)c1nc2ccc3ncnc(Nc4ccc(F)cc4Br)c3c2s1
Show InChI InChI=1S/C16H9BrFN5OS/c17-8-5-7(18)1-2-9(8)22-15-12-10(20-6-21-15)3-4-11-13(12)25-16(23-11)14(19)24/h1-6H,(H2,19,24)(H,20,21,22)
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Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-regulated kinases 1B


(Homo sapiens (Human))
BDBM50434341
PNG
(CHEMBL2386759 | US9446044, 86)
Show SMILES NC(=O)c1nc2ccc3ncnc(Nc4ccc(F)cc4Br)c3c2s1
Show InChI InChI=1S/C16H9BrFN5OS/c17-8-5-7(18)1-2-9(8)22-15-12-10(20-6-21-15)3-4-11-13(12)25-16(23-11)14(19)24/h1-6H,(H2,19,24)(H,20,21,22)
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Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


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More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM246387
PNG
(US9446044, 81)
Show SMILES CCOC(=N)c1nc2ccc3ncnc(Nc4ccc(Br)cc4F)c3c2s1
Show InChI InChI=1S/C18H13BrFN5OS/c1-2-26-16(21)18-25-13-6-5-12-14(15(13)27-18)17(23-8-22-12)24-11-4-3-9(19)7-10(11)20/h3-8,21H,2H2,1H3,(H,22,23,24)
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Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM50434345
PNG
(CHEMBL2386755 | US9446044, 83)
Show SMILES N=C(OCc1ccccc1)c1nc2ccc3ncnc(Nc4ccc5OCOc5c4)c3c2s1
Show InChI InChI=1S/C24H17N5O3S/c25-22(30-11-14-4-2-1-3-5-14)24-29-17-8-7-16-20(21(17)33-24)23(27-12-26-16)28-15-6-9-18-19(10-15)32-13-31-18/h1-10,12,25H,11,13H2,(H,26,27,28)
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Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-regulated kinases 1B


(Homo sapiens (Human))
BDBM246387
PNG
(US9446044, 81)
Show SMILES CCOC(=N)c1nc2ccc3ncnc(Nc4ccc(Br)cc4F)c3c2s1
Show InChI InChI=1S/C18H13BrFN5OS/c1-2-26-16(21)18-25-13-6-5-12-14(15(13)27-18)17(23-8-22-12)24-11-4-3-9(19)7-10(11)20/h3-8,21H,2H2,1H3,(H,22,23,24)
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Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM246390
PNG
(US9446044, 87)
Show SMILES NC(=O)c1nc2ccc3ncnc(Nc4ccc(Cl)cc4Cl)c3c2s1
Show InChI InChI=1S/C16H9Cl2N5OS/c17-7-1-2-9(8(18)5-7)22-15-12-10(20-6-21-15)3-4-11-13(12)25-16(23-11)14(19)24/h1-6H,(H2,19,24)(H,20,21,22)
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Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


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More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM50434360
PNG
(CHEMBL2386768 | US9446044, 76)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc(cc4)N(C)C)c3c2s1
Show InChI InChI=1S/C19H18N6OS/c1-25(2)12-6-4-11(5-7-12)23-18-15-13(21-10-22-18)8-9-14-16(15)27-19(24-14)17(20)26-3/h4-10,20H,1-3H3,(H,21,22,23)
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Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-regulated kinases 1B


(Homo sapiens (Human))
BDBM50434345
PNG
(CHEMBL2386755 | US9446044, 83)
Show SMILES N=C(OCc1ccccc1)c1nc2ccc3ncnc(Nc4ccc5OCOc5c4)c3c2s1
Show InChI InChI=1S/C24H17N5O3S/c25-22(30-11-14-4-2-1-3-5-14)24-29-17-8-7-16-20(21(17)33-24)23(27-12-26-16)28-15-6-9-18-19(10-15)32-13-31-18/h1-10,12,25H,11,13H2,(H,26,27,28)
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Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM50434361
PNG
(CHEMBL2386767 | US9446044, 74)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc(cc4)C(C)(C)C)c3c2s1
Show InChI InChI=1S/C21H21N5OS/c1-21(2,3)12-5-7-13(8-6-12)25-19-16-14(23-11-24-19)9-10-15-17(16)28-20(26-15)18(22)27-4/h5-11,22H,1-4H3,(H,23,24,25)
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Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM246380
PNG
(US9446044, 58)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4cccc(c4)C#C)c3c2s1
Show InChI InChI=1S/C19H13N5OS/c1-3-11-5-4-6-12(9-11)23-18-15-13(21-10-22-18)7-8-14-16(15)26-19(24-14)17(20)25-2/h1,4-10,20H,2H3,(H,21,22,23)
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Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM50434350
PNG
(CHEMBL2386750 | US9446044, 67)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4cccc(c4)C#N)c3c2s1
Show InChI InChI=1S/C18H12N6OS/c1-25-16(20)18-24-13-6-5-12-14(15(13)26-18)17(22-9-21-12)23-11-4-2-3-10(7-11)8-19/h2-7,9,20H,1H3,(H,21,22,23)
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Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


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More data for this
Ligand-Target Pair
Dual-specificity tyrosine-regulated kinases 1B


(Homo sapiens (Human))
BDBM246390
PNG
(US9446044, 87)
Show SMILES NC(=O)c1nc2ccc3ncnc(Nc4ccc(Cl)cc4Cl)c3c2s1
Show InChI InChI=1S/C16H9Cl2N5OS/c17-7-1-2-9(8(18)5-7)22-15-12-10(20-6-21-15)3-4-11-13(12)25-16(23-11)14(19)24/h1-6H,(H2,19,24)(H,20,21,22)
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Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-regulated kinases 1B


(Homo sapiens (Human))
BDBM246380
PNG
(US9446044, 58)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4cccc(c4)C#C)c3c2s1
Show InChI InChI=1S/C19H13N5OS/c1-3-11-5-4-6-12(9-11)23-18-15-13(21-10-22-18)7-8-14-16(15)26-19(24-14)17(20)25-2/h1,4-10,20H,2H3,(H,21,22,23)
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Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM246391
PNG
(US9446044, 88)
Show SMILES CCCCOC(=N)c1nc2ccc3ncnc(Nc4ccc(Cl)cc4Cl)c3c2s1
Show InChI InChI=1S/C20H17Cl2N5OS/c1-2-3-8-28-18(23)20-27-15-7-6-14-16(17(15)29-20)19(25-10-24-14)26-13-5-4-11(21)9-12(13)22/h4-7,9-10,23H,2-3,8H2,1H3,(H,24,25,26)
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Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM246386
PNG
(US9446044, 77)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc(cc4)N4CCCC4)c3c2s1
Show InChI InChI=1S/C21H20N6OS/c1-28-19(22)21-26-16-9-8-15-17(18(16)29-21)20(24-12-23-15)25-13-4-6-14(7-5-13)27-10-2-3-11-27/h4-9,12,22H,2-3,10-11H2,1H3,(H,23,24,25)
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The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


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More data for this
Ligand-Target Pair
Dual-specificity tyrosine-regulated kinases 1B


(Homo sapiens (Human))
BDBM50434360
PNG
(CHEMBL2386768 | US9446044, 76)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc(cc4)N(C)C)c3c2s1
Show InChI InChI=1S/C19H18N6OS/c1-25(2)12-6-4-11(5-7-12)23-18-15-13(21-10-22-18)8-9-14-16(15)27-19(24-14)17(20)26-3/h4-10,20H,1-3H3,(H,21,22,23)
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The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


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More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM246379
PNG
(US9446044, 57)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc(Cl)c(Cl)c4)c3c2s1
Show InChI InChI=1S/C17H11Cl2N5OS/c1-25-15(20)17-24-12-5-4-11-13(14(12)26-17)16(22-7-21-11)23-8-2-3-9(18)10(19)6-8/h2-7,20H,1H3,(H,21,22,23)
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The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


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More data for this
Ligand-Target Pair
Dual-specificity tyrosine-regulated kinases 1B


(Homo sapiens (Human))
BDBM246391
PNG
(US9446044, 88)
Show SMILES CCCCOC(=N)c1nc2ccc3ncnc(Nc4ccc(Cl)cc4Cl)c3c2s1
Show InChI InChI=1S/C20H17Cl2N5OS/c1-2-3-8-28-18(23)20-27-15-7-6-14-16(17(15)29-20)19(25-10-24-14)26-13-5-4-11(21)9-12(13)22/h4-7,9-10,23H,2-3,8H2,1H3,(H,24,25,26)
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The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


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More data for this
Ligand-Target Pair
Dual-specificity tyrosine-regulated kinases 1B


(Homo sapiens (Human))
BDBM50434350
PNG
(CHEMBL2386750 | US9446044, 67)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4cccc(c4)C#N)c3c2s1
Show InChI InChI=1S/C18H12N6OS/c1-25-16(20)18-24-13-6-5-12-14(15(13)26-18)17(22-9-21-12)23-11-4-2-3-10(7-11)8-19/h2-7,9,20H,1H3,(H,21,22,23)
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The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


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More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM246371
PNG
(US9446044, 46)
Show SMILES COC(=N)c1nc2ccc3ncnc(N(C)c4ccc(OC)cc4)c3c2s1
Show InChI InChI=1S/C19H17N5O2S/c1-24(11-4-6-12(25-2)7-5-11)18-15-13(21-10-22-18)8-9-14-16(15)27-19(23-14)17(20)26-3/h4-10,20H,1-3H3
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Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


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More data for this
Ligand-Target Pair
Dual-specificity tyrosine-regulated kinases 1B


(Homo sapiens (Human))
BDBM246371
PNG
(US9446044, 46)
Show SMILES COC(=N)c1nc2ccc3ncnc(N(C)c4ccc(OC)cc4)c3c2s1
Show InChI InChI=1S/C19H17N5O2S/c1-24(11-4-6-12(25-2)7-5-11)18-15-13(21-10-22-18)8-9-14-16(15)27-19(23-14)17(20)26-3/h4-10,20H,1-3H3
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DIAXONHIT

US Patent


Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-regulated kinases 1B


(Homo sapiens (Human))
BDBM50434361
PNG
(CHEMBL2386767 | US9446044, 74)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc(cc4)C(C)(C)C)c3c2s1
Show InChI InChI=1S/C21H21N5OS/c1-21(2,3)12-5-7-13(8-6-12)25-19-16-14(23-11-24-19)9-10-15-17(16)28-20(26-15)18(22)27-4/h5-11,22H,1-4H3,(H,23,24,25)
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DIAXONHIT

US Patent


Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-regulated kinases 1B


(Homo sapiens (Human))
BDBM246379
PNG
(US9446044, 57)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc(Cl)c(Cl)c4)c3c2s1
Show InChI InChI=1S/C17H11Cl2N5OS/c1-25-15(20)17-24-12-5-4-11-13(14(12)26-17)16(22-7-21-11)23-8-2-3-9(18)10(19)6-8/h2-7,20H,1H3,(H,21,22,23)
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DIAXONHIT

US Patent


Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM246385
PNG
(US9446044, 73)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc(OC)c(c4)[N+]([O-])=O)c3c2s1
Show InChI InChI=1S/C18H14N6O4S/c1-27-13-6-3-9(7-12(13)24(25)26)22-17-14-10(20-8-21-17)4-5-11-15(14)29-18(23-11)16(19)28-2/h3-8,19H,1-2H3,(H,20,21,22)
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DIAXONHIT

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Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM246389
PNG
(US9446044, 85)
Show SMILES CC(C)OC(=O)c1nc2ccc3ncnc(Nc4ccc5OCOc5c4)c3c2s1
Show InChI InChI=1S/C20H16N4O4S/c1-10(2)28-20(25)19-24-13-5-4-12-16(17(13)29-19)18(22-8-21-12)23-11-3-6-14-15(7-11)27-9-26-14/h3-8,10H,9H2,1-2H3,(H,21,22,23)
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Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM246374
PNG
(US9446044, 51)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc(OC)c(OC)c4)c3c2s1
Show InChI InChI=1S/C19H17N5O3S/c1-25-13-7-4-10(8-14(13)26-2)23-18-15-11(21-9-22-18)5-6-12-16(15)28-19(24-12)17(20)27-3/h4-9,20H,1-3H3,(H,21,22,23)
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Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM246365
PNG
(US9446044, 37)
Show SMILES COc1ccc(Nc2ncnc3ccc4nc(sc4c23)C(N)=O)cc1
Show InChI InChI=1S/C17H13N5O2S/c1-24-10-4-2-9(3-5-10)21-16-13-11(19-8-20-16)6-7-12-14(13)25-17(22-12)15(18)23/h2-8H,1H3,(H2,18,23)(H,19,20,21)
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DIAXONHIT

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Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM246353
PNG
(US9446044, 14)
Show SMILES CN(C)C(=N)c1nc2ccc3ncnc(Nc4ccc(Br)cc4F)c3c2s1
Show InChI InChI=1S/C18H14BrFN6S/c1-26(2)16(21)18-25-13-6-5-12-14(15(13)27-18)17(23-8-22-12)24-11-4-3-9(19)7-10(11)20/h3-8,21H,1-2H3,(H,22,23,24)
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Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-regulated kinases 1B


(Homo sapiens (Human))
BDBM246374
PNG
(US9446044, 51)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc(OC)c(OC)c4)c3c2s1
Show InChI InChI=1S/C19H17N5O3S/c1-25-13-7-4-10(8-14(13)26-2)23-18-15-11(21-9-22-18)5-6-12-16(15)28-19(24-12)17(20)27-3/h4-9,20H,1-3H3,(H,21,22,23)
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The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


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More data for this
Ligand-Target Pair
Dual-specificity tyrosine-regulated kinases 1B


(Homo sapiens (Human))
BDBM246386
PNG
(US9446044, 77)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc(cc4)N4CCCC4)c3c2s1
Show InChI InChI=1S/C21H20N6OS/c1-28-19(22)21-26-16-9-8-15-17(18(16)29-21)20(24-12-23-15)25-13-4-6-14(7-5-13)27-10-2-3-11-27/h4-9,12,22H,2-3,10-11H2,1H3,(H,23,24,25)
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Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


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More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM50434343
PNG
(CHEMBL2386757 | US9446044, 36)
Show SMILES NC(=O)c1nc2ccc3ncnc(Nc4ccc(Br)cc4F)c3c2s1
Show InChI InChI=1S/C16H9BrFN5OS/c17-7-1-2-9(8(18)5-7)22-15-12-10(20-6-21-15)3-4-11-13(12)25-16(23-11)14(19)24/h1-6H,(H2,19,24)(H,20,21,22)
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DIAXONHIT

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Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-regulated kinases 1B


(Homo sapiens (Human))
BDBM246389
PNG
(US9446044, 85)
Show SMILES CC(C)OC(=O)c1nc2ccc3ncnc(Nc4ccc5OCOc5c4)c3c2s1
Show InChI InChI=1S/C20H16N4O4S/c1-10(2)28-20(25)19-24-13-5-4-12-16(17(13)29-19)18(22-8-21-12)23-11-3-6-14-15(7-11)27-9-26-14/h3-8,10H,9H2,1-2H3,(H,21,22,23)
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Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM246382
PNG
(US9446044, 63)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4cc(OC)cc(OC)c4)c3c2s1
Show InChI InChI=1S/C19H17N5O3S/c1-25-11-6-10(7-12(8-11)26-2)23-18-15-13(21-9-22-18)4-5-14-16(15)28-19(24-14)17(20)27-3/h4-9,20H,1-3H3,(H,21,22,23)
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Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM246362
PNG
(US9446044, 33)
Show SMILES CN(C)CCNC(=N)c1nc2ccc3ncnc(Nc4ccc5OCOc5c4)c3c2s1
Show InChI InChI=1S/C21H21N7O2S/c1-28(2)8-7-23-19(22)21-27-14-5-4-13-17(18(14)31-21)20(25-10-24-13)26-12-3-6-15-16(9-12)30-11-29-15/h3-6,9-10H,7-8,11H2,1-2H3,(H2,22,23)(H,24,25,26)
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The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


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More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM50434342
PNG
(CHEMBL2386758 | US9446044, 61)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4cc(OC)c(OC)c(OC)c4)c3c2s1
Show InChI InChI=1S/C20H19N5O4S/c1-26-13-7-10(8-14(27-2)16(13)28-3)24-19-15-11(22-9-23-19)5-6-12-17(15)30-20(25-12)18(21)29-4/h5-9,21H,1-4H3,(H,22,23,24)
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Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-regulated kinases 1B


(Homo sapiens (Human))
BDBM50434342
PNG
(CHEMBL2386758 | US9446044, 61)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4cc(OC)c(OC)c(OC)c4)c3c2s1
Show InChI InChI=1S/C20H19N5O4S/c1-26-13-7-10(8-14(27-2)16(13)28-3)24-19-15-11(22-9-23-19)5-6-12-17(15)30-20(25-12)18(21)29-4/h5-9,21H,1-4H3,(H,22,23,24)
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Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM246358
PNG
(US9446044, 28)
Show SMILES COc1ccc(Nc2ncnc3ccc4nc(sc4c23)C(=N)N(C)C)cc1
Show InChI InChI=1S/C19H18N6OS/c1-25(2)17(20)19-24-14-9-8-13-15(16(14)27-19)18(22-10-21-13)23-11-4-6-12(26-3)7-5-11/h4-10,20H,1-3H3,(H,21,22,23)
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Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM246367
PNG
(US9446044, 39)
Show SMILES NC(=O)c1nc2ccc3ncnc(Nc4ccc5OCOc5c4)c3c2s1
Show InChI InChI=1S/C17H11N5O3S/c18-15(23)17-22-10-3-2-9-13(14(10)26-17)16(20-6-19-9)21-8-1-4-11-12(5-8)25-7-24-11/h1-6H,7H2,(H2,18,23)(H,19,20,21)
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The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


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More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM246376
PNG
(US9446044, 53)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc(O)cc4)c3c2s1
Show InChI InChI=1S/C17H13N5O2S/c1-24-15(18)17-22-12-7-6-11-13(14(12)25-17)16(20-8-19-11)21-9-2-4-10(23)5-3-9/h2-8,18,23H,1H3,(H,19,20,21)
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The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


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More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM246370
PNG
(US9446044, 43)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc(F)c(Cl)c4)c3c2s1
Show InChI InChI=1S/C17H11ClFN5OS/c1-25-15(20)17-24-12-5-4-11-13(14(12)26-17)16(22-7-21-11)23-8-2-3-10(19)9(18)6-8/h2-7,20H,1H3,(H,21,22,23)
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The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


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More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM246388
PNG
(US9446044, 84)
Show SMILES COC(=O)c1nc2ccc3ncnc(Nc4ccc5OCOc5c4)c3c2s1
Show InChI InChI=1S/C18H12N4O4S/c1-24-18(23)17-22-11-4-3-10-14(15(11)27-17)16(20-7-19-10)21-9-2-5-12-13(6-9)26-8-25-12/h2-7H,8H2,1H3,(H,19,20,21)
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The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


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More data for this
Ligand-Target Pair
Dual-specificity tyrosine-regulated kinases 1B


(Homo sapiens (Human))
BDBM246382
PNG
(US9446044, 63)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4cc(OC)cc(OC)c4)c3c2s1
Show InChI InChI=1S/C19H17N5O3S/c1-25-11-6-10(7-12(8-11)26-2)23-18-15-13(21-9-22-18)4-5-14-16(15)28-19(24-14)17(20)27-3/h4-9,20H,1-3H3,(H,21,22,23)
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The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


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More data for this
Ligand-Target Pair
Dual-specificity tyrosine-regulated kinases 1B


(Homo sapiens (Human))
BDBM246385
PNG
(US9446044, 73)
Show SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc(OC)c(c4)[N+]([O-])=O)c3c2s1
Show InChI InChI=1S/C18H14N6O4S/c1-27-13-6-3-9(7-12(13)24(25)26)22-17-14-10(20-8-21-17)4-5-11-15(14)29-18(23-11)16(19)28-2/h3-8,19H,1-2H3,(H,20,21,22)
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The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


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Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM246375
PNG
(US9446044, 52)
Show SMILES COC(=N)c1nc2ccc3ncnc(N(C)c4ccc(OC)c(OC)c4)c3c2s1
Show InChI InChI=1S/C20H19N5O3S/c1-25(11-5-8-14(26-2)15(9-11)27-3)19-16-12(22-10-23-19)6-7-13-17(16)29-20(24-13)18(21)28-4/h5-10,21H,1-4H3
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The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


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More data for this
Ligand-Target Pair
Dual-specificity tyrosine-regulated kinases 1B


(Homo sapiens (Human))
BDBM246375
PNG
(US9446044, 52)
Show SMILES COC(=N)c1nc2ccc3ncnc(N(C)c4ccc(OC)c(OC)c4)c3c2s1
Show InChI InChI=1S/C20H19N5O3S/c1-25(11-5-8-14(26-2)15(9-11)27-3)19-16-12(22-10-23-19)6-7-13-17(16)29-20(24-13)18(21)28-4/h5-10,21H,1-4H3
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The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


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More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM246357
PNG
(US9446044, 25)
Show SMILES COc1ccc(Nc2ncnc3ccc4nc(sc4c23)C(=N)NCc2ccccc2)cc1
Show InChI InChI=1S/C24H20N6OS/c1-31-17-9-7-16(8-10-17)29-23-20-18(27-14-28-23)11-12-19-21(20)32-24(30-19)22(25)26-13-15-5-3-2-4-6-15/h2-12,14H,13H2,1H3,(H2,25,26)(H,27,28,29)
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The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


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More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM246359
PNG
(US9446044, 29)
Show SMILES N=C(NCCN1CCOCC1)c1nc2ccc3ncnc(Nc4ccc5OCOc5c4)c3c2s1
Show InChI InChI=1S/C23H23N7O3S/c24-21(25-5-6-30-7-9-31-10-8-30)23-29-16-3-2-15-19(20(16)34-23)22(27-12-26-15)28-14-1-4-17-18(11-14)33-13-32-17/h1-4,11-12H,5-10,13H2,(H2,24,25)(H,26,27,28)
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The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


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More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM246363
PNG
(US9446044, 34)
Show SMILES CCN(CC)CCNC(=N)c1nc2ccc3ncnc(Nc4ccc5OCOc5c4)c3c2s1
Show InChI InChI=1S/C23H25N7O2S/c1-3-30(4-2)10-9-25-21(24)23-29-16-7-6-15-19(20(16)33-23)22(27-12-26-15)28-14-5-8-17-18(11-14)32-13-31-17/h5-8,11-12H,3-4,9-10,13H2,1-2H3,(H2,24,25)(H,26,27,28)
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Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


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More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM246366
PNG
(US9446044, 38)
Show SMILES COc1cc(Nc2ncnc3ccc4nc(sc4c23)C(N)=O)cc(OC)c1OC
Show InChI InChI=1S/C19H17N5O4S/c1-26-12-6-9(7-13(27-2)15(12)28-3)23-18-14-10(21-8-22-18)4-5-11-16(14)29-19(24-11)17(20)25/h4-8H,1-3H3,(H2,20,25)(H,21,22,23)
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The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


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More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM246368
PNG
(US9446044, 40)
Show SMILES COc1ccc(Nc2ncnc3ccc4nc(sc4c23)C(N)=O)cc1OC
Show InChI InChI=1S/C18H15N5O3S/c1-25-12-6-3-9(7-13(12)26-2)22-17-14-10(20-8-21-17)4-5-11-15(14)27-18(23-11)16(19)24/h3-8H,1-2H3,(H2,19,24)(H,20,21,22)
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Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM246355
PNG
(US9446044, 19)
Show SMILES Fc1cc(Br)ccc1Nc1ncnc2ccc3nc(sc3c12)C(=N)NCc1ccncc1
Show InChI InChI=1S/C22H15BrFN7S/c23-13-1-2-15(14(24)9-13)30-21-18-16(28-11-29-21)3-4-17-19(18)32-22(31-17)20(25)27-10-12-5-7-26-8-6-12/h1-9,11H,10H2,(H2,25,27)(H,28,29,30)
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The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


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More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM246354
PNG
(US9446044, 16)
Show SMILES Fc1ccc(CNC(=N)c2nc3ccc4ncnc(Nc5ccc(Br)cc5F)c4c3s2)cc1
Show InChI InChI=1S/C23H15BrF2N6S/c24-13-3-6-16(15(26)9-13)31-22-19-17(29-11-30-22)7-8-18-20(19)33-23(32-18)21(27)28-10-12-1-4-14(25)5-2-12/h1-9,11H,10H2,(H2,27,28)(H,29,30,31)
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The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


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More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM246364
PNG
(US9446044, 35)
Show SMILES NC(=O)c1nc2ccc3ncnc(Nc4ccc(F)c(Cl)c4)c3c2s1
Show InChI InChI=1S/C16H9ClFN5OS/c17-8-5-7(1-2-9(8)18)22-15-12-10(20-6-21-15)3-4-11-13(12)25-16(23-11)14(19)24/h1-6H,(H2,19,24)(H,20,21,22)
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Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM246360
PNG
(US9446044, 30)
Show SMILES N=C(NCCN1CCCCC1)c1nc2ccc3ncnc(Nc4ccc5OCOc5c4)c3c2s1
Show InChI InChI=1S/C24H25N7O2S/c25-22(26-8-11-31-9-2-1-3-10-31)24-30-17-6-5-16-20(21(17)34-24)23(28-13-27-16)29-15-4-7-18-19(12-15)33-14-32-18/h4-7,12-13H,1-3,8-11,14H2,(H2,25,26)(H,27,28,29)
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Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


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More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM246356
PNG
(US9446044, 23)
Show SMILES CCN(CC)CCNC(=N)c1nc2ccc3ncnc(Nc4ccc(OC)cc4)c3c2s1
Show InChI InChI=1S/C23H27N7OS/c1-4-30(5-2)13-12-25-21(24)23-29-18-11-10-17-19(20(18)32-23)22(27-14-26-17)28-15-6-8-16(31-3)9-7-15/h6-11,14H,4-5,12-13H2,1-3H3,(H2,24,25)(H,26,27,28)
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The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


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More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM246352
PNG
(US9446044, 7)
Show SMILES CN(C)C(=N)c1nc2ccc3ncnc(Nc4ccc(F)c(Cl)c4)c3c2s1
Show InChI InChI=1S/C18H14ClFN6S/c1-26(2)16(21)18-25-13-6-5-12-14(15(13)27-18)17(23-8-22-12)24-9-3-4-11(20)10(19)7-9/h3-8,21H,1-2H3,(H,22,23,24)
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The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


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More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM246361
PNG
(US9446044, 31)
Show SMILES N=C(NCCN1CCCC1)c1nc2ccc3ncnc(Nc4ccc5OCOc5c4)c3c2s1
Show InChI InChI=1S/C23H23N7O2S/c24-21(25-7-10-30-8-1-2-9-30)23-29-16-5-4-15-19(20(16)33-23)22(27-12-26-15)28-14-3-6-17-18(11-14)32-13-31-17/h3-6,11-12H,1-2,7-10,13H2,(H2,24,25)(H,26,27,28)
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Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM246369
PNG
(US9446044, 42)
Show SMILES COc1ccc(Nc2ncnc3ccc4nc(sc4c23)C2=NCCO2)cc1
Show InChI InChI=1S/C19H15N5O2S/c1-25-12-4-2-11(3-5-12)23-17-15-13(21-10-22-17)6-7-14-16(15)27-19(24-14)18-20-8-9-26-18/h2-7,10H,8-9H2,1H3,(H,21,22,23)
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Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-regulated kinases 1B


(Homo sapiens (Human))
BDBM246369
PNG
(US9446044, 42)
Show SMILES COc1ccc(Nc2ncnc3ccc4nc(sc4c23)C2=NCCO2)cc1
Show InChI InChI=1S/C19H15N5O2S/c1-25-12-4-2-11(3-5-12)23-17-15-13(21-10-22-17)6-7-14-16(15)27-19(24-14)18-20-8-9-26-18/h2-7,10H,8-9H2,1H3,(H,21,22,23)
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Assay Description
The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%