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Patent code US9447090

Compile Data Set for Download or QSAR
Found 34 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM247295
PNG
(US9447090, 119)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)N[C@@H](CO)c1ccccc1
Show InChI InChI=1S/C24H21F2N3O3/c1-15-22(24(31)28-20(13-30)16-7-3-2-4-8-16)29-12-6-11-21(23(29)27-15)32-14-17-18(25)9-5-10-19(17)26/h2-12,20,30H,13-14H2,1H3,(H,28,31)/t20-/m0/s1
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US Patent
n/an/an/an/a 2.90E+3n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
The activity of sGC was evaluated by measuring the amount of a cyclic guanosine monophosphate (cGMP) which is produced by human purified sGC. A test ...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM247323
PNG
(US9447090, 822)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)N[C@H]1CCCNC1
Show InChI InChI=1S/C21H22F2N4O2/c1-13-19(21(28)26-14-5-3-9-24-11-14)27-10-4-8-18(20(27)25-13)29-12-15-16(22)6-2-7-17(15)23/h2,4,6-8,10,14,24H,3,5,9,11-12H2,1H3,(H,26,28)/t14-/m0/s1
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n/an/an/an/a 5.60E+3n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
The activity of sGC was evaluated by measuring the amount of a cyclic guanosine monophosphate (cGMP) which is produced by human purified sGC. A test ...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM247312
PNG
(US9447090, 705)
Show SMILES Cc1nc2c(OCC3CCCCC3)cccn2c1C(=O)N[C@@H]1[C@H](Cc2cccc(F)c12)C(O)=O
Show InChI InChI=1S/C26H28FN3O4/c1-15-23(25(31)29-22-18(26(32)33)13-17-9-5-10-19(27)21(17)22)30-12-6-11-20(24(30)28-15)34-14-16-7-3-2-4-8-16/h5-6,9-12,16,18,22H,2-4,7-8,13-14H2,1H3,(H,29,31)(H,32,33)/t18-,22+/m0/s1
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n/an/an/an/a 1.10E+4n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
The activity of sGC was evaluated by measuring the amount of a cyclic guanosine monophosphate (cGMP) which is produced by human purified sGC. A test ...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM247319
PNG
(US9447090, 776)
Show SMILES C[C@H](CO)NC(=O)c1c(C)nc2c(OCc3c(F)cccc3F)cccn12
Show InChI InChI=1S/C19H19F2N3O3/c1-11(9-25)22-19(26)17-12(2)23-18-16(7-4-8-24(17)18)27-10-13-14(20)5-3-6-15(13)21/h3-8,11,25H,9-10H2,1-2H3,(H,22,26)/t11-/m1/s1
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n/an/an/an/a 1.50E+4n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
The activity of sGC was evaluated by measuring the amount of a cyclic guanosine monophosphate (cGMP) which is produced by human purified sGC. A test ...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM247310
PNG
(US9447090, 702)
Show SMILES Cc1nc2c(OCc3c(F)ccc(F)c3F)cccn2c1C(=O)N[C@H]1[C@@H](Cc2ccccc12)C(O)=O
Show InChI InChI=1S/C26H20F3N3O4/c1-13-23(25(33)31-22-15-6-3-2-5-14(15)11-16(22)26(34)35)32-10-4-7-20(24(32)30-13)36-12-17-18(27)8-9-19(28)21(17)29/h2-10,16,22H,11-12H2,1H3,(H,31,33)(H,34,35)/t16-,22-/m1/s1
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n/an/an/an/a 6.20E+3n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
The activity of sGC was evaluated by measuring the amount of a cyclic guanosine monophosphate (cGMP) which is produced by human purified sGC. A test ...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM247315
PNG
(US9447090, 760)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)N[C@@H]([C@H](O)CO)c1ccccc1
Show InChI InChI=1S/C25H23F2N3O4/c1-15-23(25(33)29-22(20(32)13-31)16-7-3-2-4-8-16)30-12-6-11-21(24(30)28-15)34-14-17-18(26)9-5-10-19(17)27/h2-12,20,22,31-32H,13-14H2,1H3,(H,29,33)/t20-,22-/m1/s1
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n/an/an/an/a 5.90E+3n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
The activity of sGC was evaluated by measuring the amount of a cyclic guanosine monophosphate (cGMP) which is produced by human purified sGC. A test ...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM247317
PNG
(US9447090, 767)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)N[C@]1(C[C@H](O)[C@H](O)C1)c1ccccc1
Show InChI InChI=1S/C27H25F2N3O4/c1-16-24(26(35)31-27(13-21(33)22(34)14-27)17-7-3-2-4-8-17)32-12-6-11-23(25(32)30-16)36-15-18-19(28)9-5-10-20(18)29/h2-12,21-22,33-34H,13-15H2,1H3,(H,31,35)/t21-,22+,27-
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n/an/an/an/a 3.00E+3n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
The activity of sGC was evaluated by measuring the amount of a cyclic guanosine monophosphate (cGMP) which is produced by human purified sGC. A test ...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM247320
PNG
(US9447090, 778)
Show SMILES CC(C)[C@H](CO)NC(=O)c1c(C)nc2c(OCc3c(F)cccc3F)cccn12
Show InChI InChI=1S/C21H23F2N3O3/c1-12(2)17(10-27)25-21(28)19-13(3)24-20-18(8-5-9-26(19)20)29-11-14-15(22)6-4-7-16(14)23/h4-9,12,17,27H,10-11H2,1-3H3,(H,25,28)/t17-/m0/s1
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n/an/an/an/a 6.30E+3n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
The activity of sGC was evaluated by measuring the amount of a cyclic guanosine monophosphate (cGMP) which is produced by human purified sGC. A test ...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM247325
PNG
(US9447090, 829)
Show SMILES Cc1nc2c(OCc3cccc(F)c3F)cccn2c1C(=O)NC(CO)(CO)c1ccccc1
Show InChI InChI=1S/C25H23F2N3O4/c1-16-22(24(33)29-25(14-31,15-32)18-8-3-2-4-9-18)30-12-6-11-20(23(30)28-16)34-13-17-7-5-10-19(26)21(17)27/h2-12,31-32H,13-15H2,1H3,(H,29,33)
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n/an/an/an/a 2.70E+3n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
The activity of sGC was evaluated by measuring the amount of a cyclic guanosine monophosphate (cGMP) which is produced by human purified sGC. A test ...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM247297
PNG
(US9447090, 179)
Show SMILES Cc1nc2c(OCC3CCCCC3)cccn2c1C(=O)N[C@H](CC1CCC1)CC(O)=O
Show InChI InChI=1S/C24H33N3O4/c1-16-22(24(30)26-19(14-21(28)29)13-17-9-5-10-17)27-12-6-11-20(23(27)25-16)31-15-18-7-3-2-4-8-18/h6,11-12,17-19H,2-5,7-10,13-15H2,1H3,(H,26,30)(H,28,29)/t19-/m1/s1
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n/an/an/an/a 2.70E+3n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
The activity of sGC was evaluated by measuring the amount of a cyclic guanosine monophosphate (cGMP) which is produced by human purified sGC. A test ...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM247298
PNG
(US9447090, 226)
Show SMILES CN1CCC[C@@H](C1)NC(=O)c1c(C)nc2c(OCC3CCCCC3)cccn12
Show InChI InChI=1S/C22H32N4O2/c1-16-20(22(27)24-18-10-6-12-25(2)14-18)26-13-7-11-19(21(26)23-16)28-15-17-8-4-3-5-9-17/h7,11,13,17-18H,3-6,8-10,12,14-15H2,1-2H3,(H,24,27)/t18-/m0/s1
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n/an/an/an/a 6.70E+3n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
The activity of sGC was evaluated by measuring the amount of a cyclic guanosine monophosphate (cGMP) which is produced by human purified sGC. A test ...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM247305
PNG
(US9447090, 430)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)N[C@H]1[C@H](O)Cc2ccccc12
Show InChI InChI=1S/C25H21F2N3O3/c1-14-23(25(32)29-22-16-7-3-2-6-15(16)12-20(22)31)30-11-5-10-21(24(30)28-14)33-13-17-18(26)8-4-9-19(17)27/h2-11,20,22,31H,12-13H2,1H3,(H,29,32)/t20-,22-/m1/s1
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n/an/an/an/a 2.60E+3n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
The activity of sGC was evaluated by measuring the amount of a cyclic guanosine monophosphate (cGMP) which is produced by human purified sGC. A test ...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM247309
PNG
(US9447090, 699)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)N[C@H]1[C@@H](Cc2cccc(F)c12)C(O)=O
Show InChI InChI=1S/C26H20F3N3O4/c1-13-23(25(33)31-22-15(26(34)35)11-14-5-2-8-19(29)21(14)22)32-10-4-9-20(24(32)30-13)36-12-16-17(27)6-3-7-18(16)28/h2-10,15,22H,11-12H2,1H3,(H,31,33)(H,34,35)/t15-,22+/m1/s1
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n/an/an/an/a 1.50E+4n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
The activity of sGC was evaluated by measuring the amount of a cyclic guanosine monophosphate (cGMP) which is produced by human purified sGC. A test ...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM247314
PNG
(US9447090, 759)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)N[C@H]1[C@H](O)[C@H](O)c2ccccc12
Show InChI InChI=1S/C25H21F2N3O4/c1-13-21(25(33)29-20-14-6-2-3-7-15(14)22(31)23(20)32)30-11-5-10-19(24(30)28-13)34-12-16-17(26)8-4-9-18(16)27/h2-11,20,22-23,31-32H,12H2,1H3,(H,29,33)/t20-,22-,23+/m1/s1
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n/an/an/an/a 2.20E+3n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
The activity of sGC was evaluated by measuring the amount of a cyclic guanosine monophosphate (cGMP) which is produced by human purified sGC. A test ...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM247318
PNG
(US9447090, 772)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)NC(C)(C)CO
Show InChI InChI=1S/C20H21F2N3O3/c1-12-17(19(27)24-20(2,3)11-26)25-9-5-8-16(18(25)23-12)28-10-13-14(21)6-4-7-15(13)22/h4-9,26H,10-11H2,1-3H3,(H,24,27)
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n/an/an/an/a 5.40E+3n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
The activity of sGC was evaluated by measuring the amount of a cyclic guanosine monophosphate (cGMP) which is produced by human purified sGC. A test ...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM247324
PNG
(US9447090, 828)
Show SMILES Cc1nc2c(OCc3ccccc3F)cccn2c1C(=O)NC(CO)(CO)c1ccccc1
Show InChI InChI=1S/C25H24FN3O4/c1-17-22(24(32)28-25(15-30,16-31)19-9-3-2-4-10-19)29-13-7-12-21(23(29)27-17)33-14-18-8-5-6-11-20(18)26/h2-13,30-31H,14-16H2,1H3,(H,28,32)
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n/an/an/an/a 7.60E+3n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
The activity of sGC was evaluated by measuring the amount of a cyclic guanosine monophosphate (cGMP) which is produced by human purified sGC. A test ...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM247300
PNG
(US9447090, 251)
Show SMILES Cc1nc2c(OCC3CCCCC3)cccn2c1C(=O)N[C@@H](CC(O)=O)c1ccccc1
Show InChI InChI=1S/C25H29N3O4/c1-17-23(25(31)27-20(15-22(29)30)19-11-6-3-7-12-19)28-14-8-13-21(24(28)26-17)32-16-18-9-4-2-5-10-18/h3,6-8,11-14,18,20H,2,4-5,9-10,15-16H2,1H3,(H,27,31)(H,29,30)/t20-/m0/s1
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n/an/an/an/a 6.10E+3n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
The activity of sGC was evaluated by measuring the amount of a cyclic guanosine monophosphate (cGMP) which is produced by human purified sGC. A test ...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM247304
PNG
(US9447090, 424)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)NC(CO)(CO)c1ccccc1
Show InChI InChI=1S/C25H23F2N3O4/c1-16-22(24(33)29-25(14-31,15-32)17-7-3-2-4-8-17)30-12-6-11-21(23(30)28-16)34-13-18-19(26)9-5-10-20(18)27/h2-12,31-32H,13-15H2,1H3,(H,29,33)
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n/an/an/an/a 2.40E+3n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
The activity of sGC was evaluated by measuring the amount of a cyclic guanosine monophosphate (cGMP) which is produced by human purified sGC. A test ...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM247313
PNG
(US9447090, 706)
Show SMILES Cc1nc2c(OCC3CCCCC3)cccn2c1C(=O)N[C@H]1[C@@H](Cc2cc(F)ccc12)C(O)=O
Show InChI InChI=1S/C26H28FN3O4/c1-15-23(25(31)29-22-19-10-9-18(27)12-17(19)13-20(22)26(32)33)30-11-5-8-21(24(30)28-15)34-14-16-6-3-2-4-7-16/h5,8-12,16,20,22H,2-4,6-7,13-14H2,1H3,(H,29,31)(H,32,33)/t20-,22-/m1/s1
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n/an/an/an/a 4.70E+3n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
The activity of sGC was evaluated by measuring the amount of a cyclic guanosine monophosphate (cGMP) which is produced by human purified sGC. A test ...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM247302
PNG
(US9447090, 323)
Show SMILES C[C@H](NC(=O)c1c(C)nc2c(OCC3CCCCC3)cccn12)c1cccc(c1)C(O)=O
Show InChI InChI=1S/C25H29N3O4/c1-16(19-10-6-11-20(14-19)25(30)31)27-24(29)22-17(2)26-23-21(12-7-13-28(22)23)32-15-18-8-4-3-5-9-18/h6-7,10-14,16,18H,3-5,8-9,15H2,1-2H3,(H,27,29)(H,30,31)/t16-/m0/s1
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n/an/an/an/a 1.30E+4n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
The activity of sGC was evaluated by measuring the amount of a cyclic guanosine monophosphate (cGMP) which is produced by human purified sGC. A test ...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM247306
PNG
(US9447090, 434)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)N[C@H]1[C@@H](Cc2ccccc12)C(O)=O
Show InChI InChI=1S/C26H21F2N3O4/c1-14-23(25(32)30-22-16-7-3-2-6-15(16)12-17(22)26(33)34)31-11-5-10-21(24(31)29-14)35-13-18-19(27)8-4-9-20(18)28/h2-11,17,22H,12-13H2,1H3,(H,30,32)(H,33,34)/t17-,22-/m1/s1
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n/an/an/an/a 7.30E+3n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
The activity of sGC was evaluated by measuring the amount of a cyclic guanosine monophosphate (cGMP) which is produced by human purified sGC. A test ...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM247321
PNG
(US9447090, 797)
Show SMILES Cc1nc2c(OCc3cccc(F)c3F)cccn2c1C(=O)N[C@H]1[C@H](O)[C@@H](O)c2ccccc12
Show InChI InChI=1S/C25H21F2N3O4/c1-13-21(25(33)29-20-15-7-2-3-8-16(15)22(31)23(20)32)30-11-5-10-18(24(30)28-13)34-12-14-6-4-9-17(26)19(14)27/h2-11,20,22-23,31-32H,12H2,1H3,(H,29,33)/t20-,22+,23+/m1/s1
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n/an/an/an/a 8.90E+3n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
The activity of sGC was evaluated by measuring the amount of a cyclic guanosine monophosphate (cGMP) which is produced by human purified sGC. A test ...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM247294
PNG
(US9447090, 102)
Show SMILES Cc1nc2c(OCC3CCCCC3)cccn2c1C(=O)N[C@@H](CO)c1ccccc1
Show InChI InChI=1S/C24H29N3O3/c1-17-22(24(29)26-20(15-28)19-11-6-3-7-12-19)27-14-8-13-21(23(27)25-17)30-16-18-9-4-2-5-10-18/h3,6-8,11-14,18,20,28H,2,4-5,9-10,15-16H2,1H3,(H,26,29)/t20-/m0/s1
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n/an/an/an/a 2.80E+3n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
The activity of sGC was evaluated by measuring the amount of a cyclic guanosine monophosphate (cGMP) which is produced by human purified sGC. A test ...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM247299
PNG
(US9447090, 247)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)N[C@H]1CCCN(C1)S(N)(=O)=O
Show InChI InChI=1S/C21H23F2N5O4S/c1-13-19(21(29)26-14-5-3-9-27(11-14)33(24,30)31)28-10-4-8-18(20(28)25-13)32-12-15-16(22)6-2-7-17(15)23/h2,4,6-8,10,14H,3,5,9,11-12H2,1H3,(H,26,29)(H2,24,30,31)/t14-/m0/s1
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n/an/an/an/a 2.40E+3n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
The activity of sGC was evaluated by measuring the amount of a cyclic guanosine monophosphate (cGMP) which is produced by human purified sGC. A test ...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM247307
PNG
(US9447090, 693)
Show SMILES Cc1nc2c(OCC3CCCCC3)cccn2c1C(=O)N[C@H]1[C@@H](Cc2c1cccc2C)C(O)=O
Show InChI InChI=1S/C27H31N3O4/c1-16-8-6-11-19-20(16)14-21(27(32)33)23(19)29-26(31)24-17(2)28-25-22(12-7-13-30(24)25)34-15-18-9-4-3-5-10-18/h6-8,11-13,18,21,23H,3-5,9-10,14-15H2,1-2H3,(H,29,31)(H,32,33)/t21-,23-/m1/s1
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n/an/an/an/a 1.70E+4n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
The activity of sGC was evaluated by measuring the amount of a cyclic guanosine monophosphate (cGMP) which is produced by human purified sGC. A test ...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM247311
PNG
(US9447090, 704)
Show SMILES Cc1nc2c(OCC3CCCCC3)cccn2c1C(=O)N[C@H]1[C@@H](Cc2cccc(F)c12)C(O)=O
Show InChI InChI=1S/C26H28FN3O4/c1-15-23(25(31)29-22-18(26(32)33)13-17-9-5-10-19(27)21(17)22)30-12-6-11-20(24(30)28-15)34-14-16-7-3-2-4-8-16/h5-6,9-12,16,18,22H,2-4,7-8,13-14H2,1H3,(H,29,31)(H,32,33)/t18-,22+/m1/s1
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n/an/an/an/a 1.10E+4n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
The activity of sGC was evaluated by measuring the amount of a cyclic guanosine monophosphate (cGMP) which is produced by human purified sGC. A test ...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM247316
PNG
(US9447090, 766)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)N[C@@]1(C[C@H](O)[C@H](O)C1)c1ccccc1
Show InChI InChI=1S/C27H25F2N3O4/c1-16-24(26(35)31-27(13-21(33)22(34)14-27)17-7-3-2-4-8-17)32-12-6-11-23(25(32)30-16)36-15-18-19(28)9-5-10-20(18)29/h2-12,21-22,33-34H,13-15H2,1H3,(H,31,35)/t21-,22+,27+
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n/an/an/an/a 1.70E+4n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
The activity of sGC was evaluated by measuring the amount of a cyclic guanosine monophosphate (cGMP) which is produced by human purified sGC. A test ...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM247322
PNG
(US9447090, 798)
Show SMILES Cc1nc2c(OCc3ccccc3F)cccn2c1C(=O)N[C@H]1[C@H](O)[C@@H](O)c2ccccc12
Show InChI InChI=1S/C25H22FN3O4/c1-14-21(25(32)28-20-16-8-3-4-9-17(16)22(30)23(20)31)29-12-6-11-19(24(29)27-14)33-13-15-7-2-5-10-18(15)26/h2-12,20,22-23,30-31H,13H2,1H3,(H,28,32)/t20-,22+,23+/m1/s1
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n/an/an/an/a 8.60E+3n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
The activity of sGC was evaluated by measuring the amount of a cyclic guanosine monophosphate (cGMP) which is produced by human purified sGC. A test ...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM247326
PNG
(US9447090, 834)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)NC(CO)(CO)c1ccccn1
Show InChI InChI=1S/C24H22F2N4O4/c1-15-21(23(33)29-24(13-31,14-32)20-9-2-3-10-27-20)30-11-5-8-19(22(30)28-15)34-12-16-17(25)6-4-7-18(16)26/h2-11,31-32H,12-14H2,1H3,(H,29,33)
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n/an/an/an/a 4.10E+3n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
The activity of sGC was evaluated by measuring the amount of a cyclic guanosine monophosphate (cGMP) which is produced by human purified sGC. A test ...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM247293
PNG
(US9447090, 12)
Show SMILES CC(C)C[C@H](CC(O)=O)NC(=O)c1c(C)nc2c(OCC3CCCCC3)cccn12
Show InChI InChI=1S/C23H33N3O4/c1-15(2)12-18(13-20(27)28)25-23(29)21-16(3)24-22-19(10-7-11-26(21)22)30-14-17-8-5-4-6-9-17/h7,10-11,15,17-18H,4-6,8-9,12-14H2,1-3H3,(H,25,29)(H,27,28)/t18-/m1/s1
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n/an/an/an/a 3.00E+3n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
The activity of sGC was evaluated by measuring the amount of a cyclic guanosine monophosphate (cGMP) which is produced by human purified sGC. A test ...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM247296
PNG
(US9447090, 126)
Show SMILES Cc1nc2c(OCC3CCCCC3)cccn2c1C(=O)NC(CO)CO
Show InChI InChI=1S/C19H27N3O4/c1-13-17(19(25)21-15(10-23)11-24)22-9-5-8-16(18(22)20-13)26-12-14-6-3-2-4-7-14/h5,8-9,14-15,23-24H,2-4,6-7,10-12H2,1H3,(H,21,25)
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n/an/an/an/a 1.10E+4n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
The activity of sGC was evaluated by measuring the amount of a cyclic guanosine monophosphate (cGMP) which is produced by human purified sGC. A test ...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM247308
PNG
(US9447090, 698)
Show SMILES Cc1nc2c(OCc3c(F)cccc3F)cccn2c1C(=O)N[C@H]1[C@@H](Cc2c1cccc2C)C(O)=O
Show InChI InChI=1S/C27H23F2N3O4/c1-14-6-3-7-16-17(14)12-18(27(34)35)23(16)31-26(33)24-15(2)30-25-22(10-5-11-32(24)25)36-13-19-20(28)8-4-9-21(19)29/h3-11,18,23H,12-13H2,1-2H3,(H,31,33)(H,34,35)/t18-,23-/m1/s1
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n/an/an/an/a 1.90E+4n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
The activity of sGC was evaluated by measuring the amount of a cyclic guanosine monophosphate (cGMP) which is produced by human purified sGC. A test ...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM247303
PNG
(US9447090, 341)
Show SMILES CN1CC[C@@H](C1)NC(=O)c1c(C)nc2c(OCC3CCCCC3)cccn12
Show InChI InChI=1S/C21H30N4O2/c1-15-19(21(26)23-17-10-12-24(2)13-17)25-11-6-9-18(20(25)22-15)27-14-16-7-4-3-5-8-16/h6,9,11,16-17H,3-5,7-8,10,12-14H2,1-2H3,(H,23,26)/t17-/m0/s1
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n/an/an/an/a 6.90E+3n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
The activity of sGC was evaluated by measuring the amount of a cyclic guanosine monophosphate (cGMP) which is produced by human purified sGC. A test ...


Citation and Details
More data for this
Ligand-Target Pair
Soluble guanylate cyclase (sGC)


(Homo sapiens (Human))
BDBM247301
PNG
(US9447090, 321)
Show SMILES Cc1nc2c(OCC3CCCCC3)cccn2c1C(=O)N[C@H]1[C@@H](Cc2ccccc12)C(O)=O
Show InChI InChI=1S/C26H29N3O4/c1-16-23(25(30)28-22-19-11-6-5-10-18(19)14-20(22)26(31)32)29-13-7-12-21(24(29)27-16)33-15-17-8-3-2-4-9-17/h5-7,10-13,17,20,22H,2-4,8-9,14-15H2,1H3,(H,28,30)(H,31,32)/t20-,22-/m1/s1
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n/an/an/an/a 4.50E+3n/an/an/an/a



Astellas Pharma Inc.

US Patent


Assay Description
The activity of sGC was evaluated by measuring the amount of a cyclic guanosine monophosphate (cGMP) which is produced by human purified sGC. A test ...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%