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Patent code US9452990

Compile Data Set for Download or QSAR
Found 131 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251408
PNG
(US9452990, 90)
Show SMILES CCN[C@H](CC(=O)N1CCN(CC1)c1nc(N)c2cc(OC)c(OC)c(F)c2n1)c1ccc(cc1)C#N
Show InChI InChI=1S/C26H30FN7O3/c1-4-30-19(17-7-5-16(15-28)6-8-17)14-21(35)33-9-11-34(12-10-33)26-31-23-18(25(29)32-26)13-20(36-2)24(37-3)22(23)27/h5-8,13,19,30H,4,9-12,14H2,1-3H3,(H2,29,31,32)/t19-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251420
PNG
(US9452990, 102)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](NCC1(C)COC1)c1ccc(cc1)C#N
Show InChI InChI=1S/C29H34FN7O4/c1-29(16-41-17-29)15-33-21(19-6-4-18(14-31)5-7-19)13-23(38)36-8-10-37(11-9-36)28-34-25-20(27(32)35-28)12-22(39-2)26(40-3)24(25)30/h4-7,12,21,33H,8-11,13,15-17H2,1-3H3,(H2,32,34,35)/t21-/m1/s1
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251449
PNG
(US9452990, 131)
Show SMILES CCNC(=O)[C@H](CC(=O)N1CCN(CC1)c1nc(N)c2cc(OC)c(OC)c(F)c2n1)c1ccc(F)cc1
Show InChI InChI=1S/C26H30F2N6O4/c1-4-30-25(36)17(15-5-7-16(27)8-6-15)14-20(35)33-9-11-34(12-10-33)26-31-22-18(24(29)32-26)13-19(37-2)23(38-3)21(22)28/h5-8,13,17H,4,9-12,14H2,1-3H3,(H,30,36)(H2,29,31,32)/t17-/m1/s1
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251413
PNG
(US9452990, 95)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](NC(C)C)c1ccc(cc1)C#N
Show InChI InChI=1S/C27H32FN7O3/c1-16(2)31-20(18-7-5-17(15-29)6-8-18)14-22(36)34-9-11-35(12-10-34)27-32-24-19(26(30)33-27)13-21(37-3)25(38-4)23(24)28/h5-8,13,16,20,31H,9-12,14H2,1-4H3,(H2,30,32,33)/t20-/m1/s1
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251411
PNG
(US9452990, 93)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](NCC1CC1)c1ccsc1
Show InChI InChI=1S/C25H31FN6O3S/c1-34-19-11-17-22(21(26)23(19)35-2)29-25(30-24(17)27)32-8-6-31(7-9-32)20(33)12-18(16-5-10-36-14-16)28-13-15-3-4-15/h5,10-11,14-15,18,28H,3-4,6-9,12-13H2,1-2H3,(H2,27,29,30)/t18-/m1/s1
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251397
PNG
(US9452990, 77)
Show SMILES CN[C@H](CC(=O)N1CCN(CC1)c1nc(N)c2cc(OC)c(OC)c(F)c2n1)c1ccc(cc1)C#N
Show InChI InChI=1S/C25H28FN7O3/c1-29-18(16-6-4-15(14-27)5-7-16)13-20(34)32-8-10-33(11-9-32)25-30-22-17(24(28)31-25)12-19(35-2)23(36-3)21(22)26/h4-7,12,18,29H,8-11,13H2,1-3H3,(H2,28,30,31)/t18-/m1/s1
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251348
PNG
(US9452990, 28)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(C[C@@H]1c1ccccc1)C(=O)c1cc2cc(ccc2[nH]1)C#N
Show InChI InChI=1S/C30H26FN7O3/c1-40-24-14-20-26(25(31)27(24)41-2)35-30(36-28(20)33)38-11-10-37(16-23(38)18-6-4-3-5-7-18)29(39)22-13-19-12-17(15-32)8-9-21(19)34-22/h3-9,12-14,23,34H,10-11,16H2,1-2H3,(H2,33,35,36)/t23-/m1/s1
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251330
PNG
(US9452990, 10)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(C[C@@H]1c1ccccc1)C(=O)\C=C\c1ccc(cc1)C#N
Show InChI InChI=1S/C30H27FN6O3/c1-39-24-16-22-27(26(31)28(24)40-2)34-30(35-29(22)33)37-15-14-36(18-23(37)21-6-4-3-5-7-21)25(38)13-12-19-8-10-20(17-32)11-9-19/h3-13,16,23H,14-15,18H2,1-2H3,(H2,33,34,35)/b13-12+/t23-/m1/s1
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251412
PNG
(US9452990, 94)
Show SMILES COCCCN[C@H](CC(=O)N1CCN(CC1)c1nc(N)c2cc(OC)c(OC)c(F)c2n1)c1ccc(F)cc1
Show InChI InChI=1S/C27H34F2N6O4/c1-37-14-4-9-31-20(17-5-7-18(28)8-6-17)16-22(36)34-10-12-35(13-11-34)27-32-24-19(26(30)33-27)15-21(38-2)25(39-3)23(24)29/h5-8,15,20,31H,4,9-14,16H2,1-3H3,(H2,30,32,33)/t20-/m1/s1
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251345
PNG
(US9452990, 25)
Show SMILES CC[C@H]1CN(CCN1c1nc(N)c2cc(OC)c(OC)c(F)c2n1)C(=O)c1cc2cc(ccc2[nH]1)C#N
Show InChI InChI=1S/C26H26FN7O3/c1-4-16-13-33(25(35)19-10-15-9-14(12-28)5-6-18(15)30-19)7-8-34(16)26-31-22-17(24(29)32-26)11-20(36-2)23(37-3)21(22)27/h5-6,9-11,16,30H,4,7-8,13H2,1-3H3,(H2,29,31,32)/t16-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251451
PNG
(US9452990, 80)
Show SMILES CN[C@H](CC(=O)N1CCN(CC1)c1nc(N)c2cc(OC)c(OC)c(F)c2n1)c1ccc(F)cc1
Show InChI InChI=1S/C24H28F2N6O3/c1-28-17(14-4-6-15(25)7-5-14)13-19(33)31-8-10-32(11-9-31)24-29-21-16(23(27)30-24)12-18(34-2)22(35-3)20(21)26/h4-7,12,17,28H,8-11,13H2,1-3H3,(H2,27,29,30)/t17-/m1/s1
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251402
PNG
(US9452990, 84)
Show SMILES CCN[C@H](CC(=O)N1CCN(CC1)c1nc(N)c2cc(OC)c(OC)c(F)c2n1)c1ccc(F)cc1
Show InChI InChI=1S/C25H30F2N6O3/c1-4-29-18(15-5-7-16(26)8-6-15)14-20(34)32-9-11-33(12-10-32)25-30-22-17(24(28)31-25)13-19(35-2)23(36-3)21(22)27/h5-8,13,18,29H,4,9-12,14H2,1-3H3,(H2,28,30,31)/t18-/m1/s1
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251416
PNG
(US9452990, 98)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](NCCF)c1ccc(F)cc1
Show InChI InChI=1S/C25H29F3N6O3/c1-36-19-13-17-22(21(28)23(19)37-2)31-25(32-24(17)29)34-11-9-33(10-12-34)20(35)14-18(30-8-7-26)15-3-5-16(27)6-4-15/h3-6,13,18,30H,7-12,14H2,1-2H3,(H2,29,31,32)/t18-/m1/s1
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251417
PNG
(US9452990, 99)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](N1CCCCC1)c1ccc(F)cc1
Show InChI InChI=1S/C28H34F2N6O3/c1-38-22-16-20-25(24(30)26(22)39-2)32-28(33-27(20)31)36-14-12-35(13-15-36)23(37)17-21(34-10-4-3-5-11-34)18-6-8-19(29)9-7-18/h6-9,16,21H,3-5,10-15,17H2,1-2H3,(H2,31,32,33)/t21-/m1/s1
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251389
PNG
(US9452990, 69)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(C[C@@H]1c1ccccc1)C(=O)C[C@@H](N)c1ccc(F)cc1
Show InChI InChI=1S/C29H30F2N6O3/c1-39-23-14-20-26(25(31)27(23)40-2)34-29(35-28(20)33)37-13-12-36(16-22(37)18-6-4-3-5-7-18)24(38)15-21(32)17-8-10-19(30)11-9-17/h3-11,14,21-22H,12-13,15-16,32H2,1-2H3,(H2,33,34,35)/t21-,22-/m1/s1
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251384
PNG
(US9452990, 64)
Show SMILES CC[C@H]1CN(CCN1c1nc(N)c2cc(OC)c(OC)c(F)c2n1)C(=O)C[C@@H](N)c1ccc(cc1)C#N
Show InChI InChI=1S/C26H30FN7O3/c1-4-17-14-33(21(35)12-19(29)16-7-5-15(13-28)6-8-16)9-10-34(17)26-31-23-18(25(30)32-26)11-20(36-2)24(37-3)22(23)27/h5-8,11,17,19H,4,9-10,12,14,29H2,1-3H3,(H2,30,31,32)/t17-,19+/m0/s1
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251410
PNG
(US9452990, 92)
Show SMILES CCCN[C@H](CC(=O)N1CCN(CC1)c1nc(N)c2cc(OC)c(OC)c(F)c2n1)c1ccc(Cl)s1
Show InChI InChI=1S/C24H30ClFN6O3S/c1-4-7-28-15(17-5-6-18(25)36-17)13-19(33)31-8-10-32(11-9-31)24-29-21-14(23(27)30-24)12-16(34-2)22(35-3)20(21)26/h5-6,12,15,28H,4,7-11,13H2,1-3H3,(H2,27,29,30)/t15-/m1/s1
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251378
PNG
(US9452990, 58)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(C[C@@H]1C)C(=O)C[C@@H](N)c1ccc(cc1)C#N
Show InChI InChI=1S/C25H28FN7O3/c1-14-13-32(20(34)11-18(28)16-6-4-15(12-27)5-7-16)8-9-33(14)25-30-22-17(24(29)31-25)10-19(35-2)23(36-3)21(22)26/h4-7,10,14,18H,8-9,11,13,28H2,1-3H3,(H2,29,30,31)/t14-,18+/m0/s1
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251448
PNG
(US9452990, 130)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](C(N)=O)c1ccc(F)cc1
Show InChI InChI=1S/C24H26F2N6O4/c1-35-17-11-16-20(19(26)21(17)36-2)29-24(30-22(16)27)32-9-7-31(8-10-32)18(33)12-15(23(28)34)13-3-5-14(25)6-4-13/h3-6,11,15H,7-10,12H2,1-2H3,(H2,28,34)(H2,27,29,30)/t15-/m1/s1
PDB

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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251364
PNG
(US9452990, 44)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](N)c1ccc(cc1)C#N
Show InChI InChI=1S/C24H26FN7O3/c1-34-18-11-16-21(20(25)22(18)35-2)29-24(30-23(16)28)32-9-7-31(8-10-32)19(33)12-17(27)15-5-3-14(13-26)4-6-15/h3-6,11,17H,7-10,12,27H2,1-2H3,(H2,28,29,30)/t17-/m1/s1
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251414
PNG
(US9452990, 96)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](N1CCC1)c1ccc(F)cc1
Show InChI InChI=1S/C26H30F2N6O3/c1-36-20-14-18-23(22(28)24(20)37-2)30-26(31-25(18)29)34-12-10-33(11-13-34)21(35)15-19(32-8-3-9-32)16-4-6-17(27)7-5-16/h4-7,14,19H,3,8-13,15H2,1-2H3,(H2,29,30,31)/t19-/m1/s1
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251387
PNG
(US9452990, 67)
Show SMILES CCC[C@H]1CN(CCN1c1nc(N)c2cc(OC)c(OC)c(F)c2n1)C(=O)C[C@@H](N)c1ccc(cc1)C#N
Show InChI InChI=1S/C27H32FN7O3/c1-4-5-18-15-34(22(36)13-20(30)17-8-6-16(14-29)7-9-17)10-11-35(18)27-32-24-19(26(31)33-27)12-21(37-2)25(38-3)23(24)28/h6-9,12,18,20H,4-5,10-11,13,15,30H2,1-3H3,(H2,31,32,33)/t18-,20+/m0/s1
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251328
PNG
(US9452990, 8)
Show SMILES CC[C@H]1CN(CCN1c1nc(N)c2cc(OC)c(OC)c(F)c2n1)C(=O)\C=C\c1ccc(cc1)C#N
Show InChI InChI=1S/C26H27FN6O3/c1-4-18-15-32(21(34)10-9-16-5-7-17(14-28)8-6-16)11-12-33(18)26-30-23-19(25(29)31-26)13-20(35-2)24(36-3)22(23)27/h5-10,13,18H,4,11-12,15H2,1-3H3,(H2,29,30,31)/b10-9+/t18-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251415
PNG
(US9452990, 97)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1[C@@H](C)CN(C[C@H]1C)C(=O)C[C@@H](NC(C)C)c1ccc(cc1)C#N
Show InChI InChI=1S/C29H36FN7O3/c1-16(2)33-22(20-9-7-19(13-31)8-10-20)12-24(38)36-14-17(3)37(18(4)15-36)29-34-26-21(28(32)35-29)11-23(39-5)27(40-6)25(26)30/h7-11,16-18,22,33H,12,14-15H2,1-6H3,(H2,32,34,35)/t17-,18+,22-/m1/s1
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251346
PNG
(US9452990, 26)
Show SMILES CCC[C@H]1CN(CCN1c1nc(N)c2cc(OC)c(OC)c(F)c2n1)C(=O)c1cc2cc(ccc2[nH]1)C#N
Show InChI InChI=1S/C27H28FN7O3/c1-4-5-17-14-34(26(36)20-11-16-10-15(13-29)6-7-19(16)31-20)8-9-35(17)27-32-23-18(25(30)33-27)12-21(37-2)24(38-3)22(23)28/h6-7,10-12,17,31H,4-5,8-9,14H2,1-3H3,(H2,30,32,33)/t17-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251409
PNG
(US9452990, 91)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](NC(C)C)c1ccc(F)c(c1)C#N
Show InChI InChI=1S/C27H31F2N7O3/c1-15(2)32-20(16-5-6-19(28)17(11-16)14-30)13-22(37)35-7-9-36(10-8-35)27-33-24-18(26(31)34-27)12-21(38-3)25(39-4)23(24)29/h5-6,11-12,15,20,32H,7-10,13H2,1-4H3,(H2,31,33,34)/t20-/m1/s1
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251419
PNG
(US9452990, 101)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](NC(C)C)c1ccc(F)cn1
Show InChI InChI=1S/C25H31F2N7O3/c1-14(2)30-18(17-6-5-15(26)13-29-17)12-20(35)33-7-9-34(10-8-33)25-31-22-16(24(28)32-25)11-19(36-3)23(37-4)21(22)27/h5-6,11,13-14,18,30H,7-10,12H2,1-4H3,(H2,28,31,32)/t18-/m1/s1
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251349
PNG
(US9452990, 29)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(C[C@@H]1c1ccccc1)C(=O)c1cc2cc(F)ccc2[nH]1
Show InChI InChI=1S/C29H26F2N6O3/c1-39-23-14-19-25(24(31)26(23)40-2)34-29(35-27(19)32)37-11-10-36(15-22(37)16-6-4-3-5-7-16)28(38)21-13-17-12-18(30)8-9-20(17)33-21/h3-9,12-14,22,33H,10-11,15H2,1-2H3,(H2,32,34,35)/t22-/m1/s1
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251421
PNG
(US9452990, 103)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](N1CCCC1)c1ccc(F)cc1
Show InChI InChI=1S/C27H32F2N6O3/c1-37-21-15-19-24(23(29)25(21)38-2)31-27(32-26(19)30)35-13-11-34(12-14-35)22(36)16-20(33-9-3-4-10-33)17-5-7-18(28)8-6-17/h5-8,15,20H,3-4,9-14,16H2,1-2H3,(H2,30,31,32)/t20-/m1/s1
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251343
PNG
(US9452990, 23)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(C[C@@H]1C)C(=O)c1cc2cc(ccc2[nH]1)C#N
Show InChI InChI=1S/C25H24FN7O3/c1-13-12-32(24(34)18-9-15-8-14(11-27)4-5-17(15)29-18)6-7-33(13)25-30-21-16(23(28)31-25)10-19(35-2)22(36-3)20(21)26/h4-5,8-10,13,29H,6-7,12H2,1-3H3,(H2,28,30,31)/t13-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251322
PNG
(US9452990, 2)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)\C=C\c1ccc(cc1)C#N
Show InChI InChI=1S/C24H23FN6O3/c1-33-18-13-17-21(20(25)22(18)34-2)28-24(29-23(17)27)31-11-9-30(10-12-31)19(32)8-7-15-3-5-16(14-26)6-4-15/h3-8,13H,9-12H2,1-2H3,(H2,27,28,29)/b8-7+
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251342
PNG
(US9452990, 22)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)c1cc2cc(F)cc(F)c2[nH]1
Show InChI InChI=1S/C23H21F3N6O3/c1-34-16-10-13-19(17(26)20(16)35-2)29-23(30-21(13)27)32-5-3-31(4-6-32)22(33)15-8-11-7-12(24)9-14(25)18(11)28-15/h7-10,28H,3-6H2,1-2H3,(H2,27,29,30)
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251327
PNG
(US9452990, 7)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(C[C@@H]1C)C(=O)\C=C\c1ccc(cc1)C#N
Show InChI InChI=1S/C25H25FN6O3/c1-15-14-31(20(33)9-8-16-4-6-17(13-27)7-5-16)10-11-32(15)25-29-22-18(24(28)30-25)12-19(34-2)23(35-3)21(22)26/h4-9,12,15H,10-11,14H2,1-3H3,(H2,28,29,30)/b9-8+/t15-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251338
PNG
(US9452990, 18)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)c1cc2cc(ccc2[nH]1)C#N
Show InChI InChI=1S/C24H22FN7O3/c1-34-18-11-15-20(19(25)21(18)35-2)29-24(30-22(15)27)32-7-5-31(6-8-32)23(33)17-10-14-9-13(12-26)3-4-16(14)28-17/h3-4,9-11,28H,5-8H2,1-2H3,(H2,27,29,30)
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251439
PNG
(US9452990, 121)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(C[C@@H]1c1ccccc1)C(=O)C[C@@H]1CCCCN1
Show InChI InChI=1S/C27H33FN6O3/c1-36-21-15-19-24(23(28)25(21)37-2)31-27(32-26(19)29)34-13-12-33(16-20(34)17-8-4-3-5-9-17)22(35)14-18-10-6-7-11-30-18/h3-5,8-9,15,18,20,30H,6-7,10-14,16H2,1-2H3,(H2,29,31,32)/t18-,20+/m0/s1
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251418
PNG
(US9452990, 100)
Show SMILES COCCN[C@H](CC(=O)N1CCN(CC1)c1nc(N)c2cc(OC)c(OC)c(F)c2n1)c1ccc(F)cc1
Show InChI InChI=1S/C26H32F2N6O4/c1-36-13-8-30-19(16-4-6-17(27)7-5-16)15-21(35)33-9-11-34(12-10-33)26-31-23-18(25(29)32-26)14-20(37-2)24(38-3)22(23)28/h4-7,14,19,30H,8-13,15H2,1-3H3,(H2,29,31,32)/t19-/m1/s1
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251329
PNG
(US9452990, 9)
Show SMILES CCC[C@H]1CN(CCN1c1nc(N)c2cc(OC)c(OC)c(F)c2n1)C(=O)\C=C\c1ccc(cc1)C#N
Show InChI InChI=1S/C27H29FN6O3/c1-4-5-19-16-33(22(35)11-10-17-6-8-18(15-29)9-7-17)12-13-34(19)27-31-24-20(26(30)32-27)14-21(36-2)25(37-3)23(24)28/h6-11,14,19H,4-5,12-13,16H2,1-3H3,(H2,30,31,32)/b11-10+/t19-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251380
PNG
(US9452990, 60)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(C[C@@H]1C)C(=O)C[C@@H](N)c1ccc(F)cc1
Show InChI InChI=1S/C24H28F2N6O3/c1-13-12-31(19(33)11-17(27)14-4-6-15(25)7-5-14)8-9-32(13)24-29-21-16(23(28)30-24)10-18(34-2)22(35-3)20(21)26/h4-7,10,13,17H,8-9,11-12,27H2,1-3H3,(H2,28,29,30)/t13-,17+/m0/s1
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251401
PNG
(US9452990, 83)
Show SMILES COc1cc2nc(nc(N)c2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](N)c1ccc(F)cc1
Show InChI InChI=1S/C23H26F2N6O3/c1-33-17-12-16-19(20(25)21(17)34-2)22(27)29-23(28-16)31-9-7-30(8-10-31)18(32)11-15(26)13-3-5-14(24)6-4-13/h3-6,12,15H,7-11,26H2,1-2H3,(H2,27,28,29)/t15-/m1/s1
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251407
PNG
(US9452990, 89)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](NC(C)C)c1ccc(F)cc1
Show InChI InChI=1S/C26H32F2N6O3/c1-15(2)30-19(16-5-7-17(27)8-6-16)14-21(35)33-9-11-34(12-10-33)26-31-23-18(25(29)32-26)13-20(36-3)24(37-4)22(23)28/h5-8,13,15,19,30H,9-12,14H2,1-4H3,(H2,29,31,32)/t19-/m1/s1
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NOVARTIS AG

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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251406
PNG
(US9452990, 88)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](NCC(F)(F)F)c1ccc(F)cc1
Show InChI InChI=1S/C25H27F5N6O3/c1-38-18-11-16-21(20(27)22(18)39-2)33-24(34-23(16)31)36-9-7-35(8-10-36)19(37)12-17(32-13-25(28,29)30)14-3-5-15(26)6-4-14/h3-6,11,17,32H,7-10,12-13H2,1-2H3,(H2,31,33,34)/t17-/m1/s1
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NOVARTIS AG

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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251385
PNG
(US9452990, 65)
Show SMILES CC[C@H]1CN(CCN1c1nc(N)c2cc(OC)c(OC)c(F)c2n1)C(=O)C[C@@H](N)c1ccc(F)cc1
Show InChI InChI=1S/C25H30F2N6O3/c1-4-16-13-32(20(34)12-18(28)14-5-7-15(26)8-6-14)9-10-33(16)25-30-22-17(24(29)31-25)11-19(35-2)23(36-3)21(22)27/h5-8,11,16,18H,4,9-10,12-13,28H2,1-3H3,(H2,29,30,31)/t16-,18+/m0/s1
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NOVARTIS AG

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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251405
PNG
(US9452990, 87)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](NC(CF)CF)c1ccc(F)cc1
Show InChI InChI=1S/C26H30F4N6O3/c1-38-20-11-18-23(22(30)24(20)39-2)33-26(34-25(18)31)36-9-7-35(8-10-36)21(37)12-19(32-17(13-27)14-28)15-3-5-16(29)6-4-15/h3-6,11,17,19,32H,7-10,12-14H2,1-2H3,(H2,31,33,34)/t19-/m1/s1
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NOVARTIS AG

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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251363
PNG
(US9452990, 43)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](N)c1cccc(c1)C#N
Show InChI InChI=1S/C24H26FN7O3/c1-34-18-11-16-21(20(25)22(18)35-2)29-24(30-23(16)28)32-8-6-31(7-9-32)19(33)12-17(27)15-5-3-4-14(10-15)13-26/h3-5,10-11,17H,6-9,12,27H2,1-2H3,(H2,28,29,30)/t17-/m1/s1
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NOVARTIS AG

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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251357
PNG
(US9452990, 37)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](N)c1ccsc1
Show InChI InChI=1S/C21H25FN6O3S/c1-30-15-9-13-18(17(22)19(15)31-2)25-21(26-20(13)24)28-6-4-27(5-7-28)16(29)10-14(23)12-3-8-32-11-12/h3,8-9,11,14H,4-7,10,23H2,1-2H3,(H2,24,25,26)/t14-/m1/s1
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NOVARTIS AG

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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251404
PNG
(US9452990, 86)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](N(C)C)c1ccc(F)cc1
Show InChI InChI=1S/C25H30F2N6O3/c1-31(2)18(15-5-7-16(26)8-6-15)14-20(34)32-9-11-33(12-10-32)25-29-22-17(24(28)30-25)13-19(35-3)23(36-4)21(22)27/h5-8,13,18H,9-12,14H2,1-4H3,(H2,28,29,30)/t18-/m1/s1
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NOVARTIS AG

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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251381
PNG
(US9452990, 61)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(C[C@@H]1C)C(=O)C[C@@H](N)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C25H28F4N6O3/c1-13-12-34(19(36)11-17(30)14-4-6-15(7-5-14)25(27,28)29)8-9-35(13)24-32-21-16(23(31)33-24)10-18(37-2)22(38-3)20(21)26/h4-7,10,13,17H,8-9,11-12,30H2,1-3H3,(H2,31,32,33)/t13-,17+/m0/s1
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NOVARTIS AG

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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251366
PNG
(US9452990, 46)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](N)c1ccc(F)cc1
Show InChI InChI=1S/C23H26F2N6O3/c1-33-17-11-15-20(19(25)21(17)34-2)28-23(29-22(15)27)31-9-7-30(8-10-31)18(32)12-16(26)13-3-5-14(24)6-4-13/h3-6,11,16H,7-10,12,26H2,1-2H3,(H2,27,28,29)/t16-/m1/s1
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NOVARTIS AG

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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251365
PNG
(US9452990, 45)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](N)c1cccc(F)c1
Show InChI InChI=1S/C23H26F2N6O3/c1-33-17-11-15-20(19(25)21(17)34-2)28-23(29-22(15)27)31-8-6-30(7-9-31)18(32)12-16(26)13-4-3-5-14(24)10-13/h3-5,10-11,16H,6-9,12,26H2,1-2H3,(H2,27,28,29)/t16-/m1/s1
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NOVARTIS AG

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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251394
PNG
(US9452990, 74)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1C[C@@H](C)N(C[C@@H]1C)C(=O)C[C@@H](N)c1ccc(F)cc1
Show InChI InChI=1S/C25H30F2N6O3/c1-13-12-33(14(2)11-32(13)20(34)10-18(28)15-5-7-16(26)8-6-15)25-30-22-17(24(29)31-25)9-19(35-3)23(36-4)21(22)27/h5-9,13-14,18H,10-12,28H2,1-4H3,(H2,29,30,31)/t13-,14+,18-/m1/s1
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NOVARTIS AG

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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251373
PNG
(US9452990, 53)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](N)c1ccc(cc1)C(F)F
Show InChI InChI=1S/C24H27F3N6O3/c1-35-17-11-15-20(19(25)21(17)36-2)30-24(31-23(15)29)33-9-7-32(8-10-33)18(34)12-16(28)13-3-5-14(6-4-13)22(26)27/h3-6,11,16,22H,7-10,12,28H2,1-2H3,(H2,29,30,31)/t16-/m1/s1
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NOVARTIS AG

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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251392
PNG
(US9452990, 72 | US9452990, 79)
Show SMILES CN[C@H](CC(=O)N1CCN(CC1)c1nc(N)c2cc(OC)c(OC)c(F)c2n1)c1ccccc1
Show InChI InChI=1S/C24H29FN6O3/c1-27-17(15-7-5-4-6-8-15)14-19(32)30-9-11-31(12-10-30)24-28-21-16(23(26)29-24)13-18(33-2)22(34-3)20(21)25/h4-8,13,17,27H,9-12,14H2,1-3H3,(H2,26,28,29)/t17-/m1/s1
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NOVARTIS AG

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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251369
PNG
(US9452990, 49)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](N)c1ccc(Br)cc1
Show InChI InChI=1S/C23H26BrFN6O3/c1-33-17-11-15-20(19(25)21(17)34-2)28-23(29-22(15)27)31-9-7-30(8-10-31)18(32)12-16(26)13-3-5-14(24)6-4-13/h3-6,11,16H,7-10,12,26H2,1-2H3,(H2,27,28,29)/t16-/m1/s1
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NOVARTIS AG

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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251393
PNG
(US9452990, 73)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1C[C@@H](C)N(C[C@@H]1C)C(=O)C[C@@H](N)c1ccccc1
Show InChI InChI=1S/C25H31FN6O3/c1-14-13-32(15(2)12-31(14)20(33)11-18(27)16-8-6-5-7-9-16)25-29-22-17(24(28)30-25)10-19(34-3)23(35-4)21(22)26/h5-10,14-15,18H,11-13,27H2,1-4H3,(H2,28,29,30)/t14-,15+,18-/m1/s1
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NOVARTIS AG

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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251388
PNG
(US9452990, 68)
Show SMILES CCC[C@H]1CN(CCN1c1nc(N)c2cc(OC)c(OC)c(F)c2n1)C(=O)C[C@@H](N)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C27H32F4N6O3/c1-4-5-17-14-36(21(38)13-19(32)15-6-8-16(9-7-15)27(29,30)31)10-11-37(17)26-34-23-18(25(33)35-26)12-20(39-2)24(40-3)22(23)28/h6-9,12,17,19H,4-5,10-11,13-14,32H2,1-3H3,(H2,33,34,35)/t17-,19+/m0/s1
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NOVARTIS AG

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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251341
PNG
(US9452990, 21)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)c1cc2cc(F)ccc2[nH]1
Show InChI InChI=1S/C23H22F2N6O3/c1-33-17-11-14-19(18(25)20(17)34-2)28-23(29-21(14)26)31-7-5-30(6-8-31)22(32)16-10-12-9-13(24)3-4-15(12)27-16/h3-4,9-11,27H,5-8H2,1-2H3,(H2,26,28,29)
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NOVARTIS AG

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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251350
PNG
(US9452990, 30)
Show SMILES COCCOc1c(OC)cc2c(N)nc(nc2c1F)N1CCN(C[C@@H]1C)C(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C26H28ClFN6O4/c1-14-13-33(25(35)19-11-15-10-16(27)4-5-18(15)30-19)6-7-34(14)26-31-22-17(24(29)32-26)12-20(37-3)23(21(22)28)38-9-8-36-2/h4-5,10-12,14,30H,6-9,13H2,1-3H3,(H2,29,31,32)/t14-/m0/s1
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NOVARTIS AG

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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251391
PNG
(US9452990, 71)
Show SMILES COCCOc1c(OC)cc2c(N)nc(nc2c1F)N1CCN(C[C@@H]1C)C(=O)C[C@@H](N)c1ccc(cc1)C#N
Show InChI InChI=1S/C27H32FN7O4/c1-16-15-34(22(36)13-20(30)18-6-4-17(14-29)5-7-18)8-9-35(16)27-32-24-19(26(31)33-27)12-21(38-3)25(23(24)28)39-11-10-37-2/h4-7,12,16,20H,8-11,13,15,30H2,1-3H3,(H2,31,32,33)/t16-,20+/m0/s1
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NOVARTIS AG

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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251361
PNG
(US9452990, 41)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](N)c1ccc(C)cc1
Show InChI InChI=1S/C24H29FN6O3/c1-14-4-6-15(7-5-14)17(26)13-19(32)30-8-10-31(11-9-30)24-28-21-16(23(27)29-24)12-18(33-2)22(34-3)20(21)25/h4-7,12,17H,8-11,13,26H2,1-3H3,(H2,27,28,29)/t17-/m1/s1
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NOVARTIS AG

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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


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More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251398
PNG
(US9452990, 78)
Show SMILES CN[C@H](CC(=O)N1CCN(CC1)c1nc(N)c2cc(OC)c(OC)c(F)c2n1)C1CCCCC1
Show InChI InChI=1S/C24H35FN6O3/c1-27-17(15-7-5-4-6-8-15)14-19(32)30-9-11-31(12-10-30)24-28-21-16(23(26)29-24)13-18(33-2)22(34-3)20(21)25/h13,15,17,27H,4-12,14H2,1-3H3,(H2,26,28,29)/t17-/m1/s1
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NOVARTIS AG

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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251403
PNG
(US9452990, 85)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](N(C)C)c1ccccc1
Show InChI InChI=1S/C25H31FN6O3/c1-30(2)18(16-8-6-5-7-9-16)15-20(33)31-10-12-32(13-11-31)25-28-22-17(24(27)29-25)14-19(34-3)23(35-4)21(22)26/h5-9,14,18H,10-13,15H2,1-4H3,(H2,27,28,29)/t18-/m1/s1
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NOVARTIS AG

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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251438
PNG
(US9452990, 120)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(C[C@@H]1c1ccccc1)C(=O)C[C@@H]1CCCN1
Show InChI InChI=1S/C26H31FN6O3/c1-35-20-14-18-23(22(27)24(20)36-2)30-26(31-25(18)28)33-12-11-32(21(34)13-17-9-6-10-29-17)15-19(33)16-7-4-3-5-8-16/h3-5,7-8,14,17,19,29H,6,9-13,15H2,1-2H3,(H2,28,30,31)/t17-,19+/m0/s1
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NOVARTIS AG

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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251339
PNG
(US9452990, 19)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)c1cc2cc(O)ccc2[nH]1
Show InChI InChI=1S/C23H23FN6O4/c1-33-17-11-14-19(18(24)20(17)34-2)27-23(28-21(14)25)30-7-5-29(6-8-30)22(32)16-10-12-9-13(31)3-4-15(12)26-16/h3-4,9-11,26,31H,5-8H2,1-2H3,(H2,25,27,28)
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NOVARTIS AG

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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251368
PNG
(US9452990, 48)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](N)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H26ClFN6O3/c1-33-17-11-15-20(19(25)21(17)34-2)28-23(29-22(15)27)31-9-7-30(8-10-31)18(32)12-16(26)13-3-5-14(24)6-4-13/h3-6,11,16H,7-10,12,26H2,1-2H3,(H2,27,28,29)/t16-/m1/s1
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NOVARTIS AG

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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251354
PNG
(US9452990, 34)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](N)c1ccco1
Show InChI InChI=1S/C21H25FN6O4/c1-30-15-10-12-18(17(22)19(15)31-2)25-21(26-20(12)24)28-7-5-27(6-8-28)16(29)11-13(23)14-4-3-9-32-14/h3-4,9-10,13H,5-8,11,23H2,1-2H3,(H2,24,25,26)/t13-/m1/s1
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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251344
PNG
(US9452990, 24)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(C[C@@H]1C)C(=O)c1cc2cc(F)ccc2[nH]1
Show InChI InChI=1S/C24H24F2N6O3/c1-12-11-31(23(33)17-9-13-8-14(25)4-5-16(13)28-17)6-7-32(12)24-29-20-15(22(27)30-24)10-18(34-2)21(35-3)19(20)26/h4-5,8-10,12,28H,6-7,11H2,1-3H3,(H2,27,29,30)/t12-/m0/s1
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NOVARTIS AG

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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251386
PNG
(US9452990, 66)
Show SMILES CC[C@H]1CN(CCN1c1nc(N)c2cc(OC)c(OC)c(F)c2n1)C(=O)C[C@@H](N)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C26H30F4N6O3/c1-4-16-13-35(20(37)12-18(31)14-5-7-15(8-6-14)26(28,29)30)9-10-36(16)25-33-22-17(24(32)34-25)11-19(38-2)23(39-3)21(22)27/h5-8,11,16,18H,4,9-10,12-13,31H2,1-3H3,(H2,32,33,34)/t16-,18+/m0/s1
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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251396
PNG
(US9452990, 76)
Show SMILES COc1cc2c(N)nc(nc2c(C#N)c1OC)N1CCN(CC1)C(=O)C[C@@H](N)c1ccc(F)cc1
Show InChI InChI=1S/C24H26FN7O3/c1-34-19-11-16-21(17(13-26)22(19)35-2)29-24(30-23(16)28)32-9-7-31(8-10-32)20(33)12-18(27)14-3-5-15(25)6-4-14/h3-6,11,18H,7-10,12,27H2,1-2H3,(H2,28,29,30)/t18-/m1/s1
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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251352
PNG
(US9452990, 32)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](N)C1CCCC1
Show InChI InChI=1S/C22H31FN6O3/c1-31-16-11-14-19(18(23)20(16)32-2)26-22(27-21(14)25)29-9-7-28(8-10-29)17(30)12-15(24)13-5-3-4-6-13/h11,13,15H,3-10,12,24H2,1-2H3,(H2,25,26,27)/t15-/m1/s1
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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251367
PNG
(US9452990, 47)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](N)c1cccc(Cl)c1
Show InChI InChI=1S/C23H26ClFN6O3/c1-33-17-11-15-20(19(25)21(17)34-2)28-23(29-22(15)27)31-8-6-30(7-9-31)18(32)12-16(26)13-4-3-5-14(24)10-13/h3-5,10-11,16H,6-9,12,26H2,1-2H3,(H2,27,28,29)/t16-/m1/s1
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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251372
PNG
(US9452990, 52)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](N)c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C23H25ClF2N6O3/c1-34-17-10-13-20(19(26)21(17)35-2)29-23(30-22(13)28)32-7-5-31(6-8-32)18(33)11-16(27)12-3-4-15(25)14(24)9-12/h3-4,9-10,16H,5-8,11,27H2,1-2H3,(H2,28,29,30)/t16-/m1/s1
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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251390
PNG
(US9452990, 70)
Show SMILES COCCOc1c(OC)cc2c(N)nc(nc2c1F)N1CCN(CC1)C(=O)C[C@@H](N)c1ccc(cc1)C#N
Show InChI InChI=1S/C26H30FN7O4/c1-36-11-12-38-24-20(37-2)13-18-23(22(24)27)31-26(32-25(18)30)34-9-7-33(8-10-34)21(35)14-19(29)17-5-3-16(15-28)4-6-17/h3-6,13,19H,7-12,14,29H2,1-2H3,(H2,30,31,32)/t19-/m1/s1
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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251446
PNG
(US9452990, 128)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)CC1NCCc2cc(F)ccc12
Show InChI InChI=1S/C25H28F2N6O3/c1-35-19-12-17-22(21(27)23(19)36-2)30-25(31-24(17)28)33-9-7-32(8-10-33)20(34)13-18-16-4-3-15(26)11-14(16)5-6-29-18/h3-4,11-12,18,29H,5-10,13H2,1-2H3,(H2,28,30,31)
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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251332
PNG
(US9452990, 12)
Show SMILES COc1cc2nc(nc(N)c2c(F)c1OC)N1CCN(CC1)C(=O)\C=C\C1CC1
Show InChI InChI=1S/C20H24FN5O3/c1-28-14-11-13-16(17(21)18(14)29-2)19(22)24-20(23-13)26-9-7-25(8-10-26)15(27)6-5-12-3-4-12/h5-6,11-12H,3-4,7-10H2,1-2H3,(H2,22,23,24)/b6-5+
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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251428
PNG
(US9452990, 110)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H]1CCCN1
Show InChI InChI=1S/C20H27FN6O3/c1-29-14-11-13-17(16(21)18(14)30-2)24-20(25-19(13)22)27-8-6-26(7-9-27)15(28)10-12-4-3-5-23-12/h11-12,23H,3-10H2,1-2H3,(H2,22,24,25)/t12-/m0/s1
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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251375
PNG
(US9452990, 55)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](N)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C24H26F4N6O3/c1-36-17-11-15-20(19(25)21(17)37-2)31-23(32-22(15)30)34-9-7-33(8-10-34)18(35)12-16(29)13-3-5-14(6-4-13)24(26,27)28/h3-6,11,16H,7-10,12,29H2,1-2H3,(H2,30,31,32)/t16-/m1/s1
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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251379
PNG
(US9452990, 59)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(C[C@@H]1C)C(=O)C[C@@H](N)c1ccccc1F
Show InChI InChI=1S/C24H28F2N6O3/c1-13-12-31(19(33)11-17(27)14-6-4-5-7-16(14)25)8-9-32(13)24-29-21-15(23(28)30-24)10-18(34-2)22(35-3)20(21)26/h4-7,10,13,17H,8-9,11-12,27H2,1-3H3,(H2,28,29,30)/t13-,17+/m0/s1
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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251426
PNG
(US9452990, 108)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H]1CCCN1CC(C)C
Show InChI InChI=1S/C24H35FN6O3/c1-15(2)14-31-7-5-6-16(31)12-19(32)29-8-10-30(11-9-29)24-27-21-17(23(26)28-24)13-18(33-3)22(34-4)20(21)25/h13,15-16H,5-12,14H2,1-4H3,(H2,26,27,28)/t16-/m0/s1
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NOVARTIS AG

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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251371
PNG
(US9452990, 51)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](N)c1ccc(F)c(F)c1
Show InChI InChI=1S/C23H25F3N6O3/c1-34-17-10-13-20(19(26)21(17)35-2)29-23(30-22(13)28)32-7-5-31(6-8-32)18(33)11-16(27)12-3-4-14(24)15(25)9-12/h3-4,9-10,16H,5-8,11,27H2,1-2H3,(H2,28,29,30)/t16-/m1/s1
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NOVARTIS AG

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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251358
PNG
(US9452990, 38)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](N)c1ccc(C)s1
Show InChI InChI=1S/C22H27FN6O3S/c1-12-4-5-16(33-12)14(24)11-17(30)28-6-8-29(9-7-28)22-26-19-13(21(25)27-22)10-15(31-2)20(32-3)18(19)23/h4-5,10,14H,6-9,11,24H2,1-3H3,(H2,25,26,27)/t14-/m1/s1
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NOVARTIS AG

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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251326
PNG
(US9452990, 6)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(C[C@@H]1C)C(=O)\C=C\C1CCC1
Show InChI InChI=1S/C22H28FN5O3/c1-13-12-27(17(29)8-7-14-5-4-6-14)9-10-28(13)22-25-19-15(21(24)26-22)11-16(30-2)20(31-3)18(19)23/h7-8,11,13-14H,4-6,9-10,12H2,1-3H3,(H2,24,25,26)/b8-7+/t13-/m0/s1
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NOVARTIS AG

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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251356
PNG
(US9452990, 36)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](N)c1cccs1
Show InChI InChI=1S/C21H25FN6O3S/c1-30-14-10-12-18(17(22)19(14)31-2)25-21(26-20(12)24)28-7-5-27(6-8-28)16(29)11-13(23)15-4-3-9-32-15/h3-4,9-10,13H,5-8,11,23H2,1-2H3,(H2,24,25,26)/t13-/m1/s1
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NOVARTIS AG

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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251440
PNG
(US9452990, 122)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(C[C@@H]1c1ccccc1)C(=O)C[C@@H]1CCCNC1
Show InChI InChI=1S/C27H33FN6O3/c1-36-21-14-19-24(23(28)25(21)37-2)31-27(32-26(19)29)34-12-11-33(16-20(34)18-8-4-3-5-9-18)22(35)13-17-7-6-10-30-15-17/h3-5,8-9,14,17,20,30H,6-7,10-13,15-16H2,1-2H3,(H2,29,31,32)/t17-,20+/m0/s1
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NOVARTIS AG

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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251445
PNG
(US9452990, 127)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)CC1NCCc2ccccc12
Show InChI InChI=1S/C25H29FN6O3/c1-34-19-13-17-22(21(26)23(19)35-2)29-25(30-24(17)27)32-11-9-31(10-12-32)20(33)14-18-16-6-4-3-5-15(16)7-8-28-18/h3-6,13,18,28H,7-12,14H2,1-2H3,(H2,27,29,30)
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NOVARTIS AG

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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251377
PNG
(US9452990, 57)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(C[C@@H]1C)C(=O)C[C@@H](N)c1ccccc1
Show InChI InChI=1S/C24H29FN6O3/c1-14-13-30(19(32)12-17(26)15-7-5-4-6-8-15)9-10-31(14)24-28-21-16(23(27)29-24)11-18(33-2)22(34-3)20(21)25/h4-8,11,14,17H,9-10,12-13,26H2,1-3H3,(H2,27,28,29)/t14-,17+/m0/s1
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NOVARTIS AG

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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251360
PNG
(US9452990, 40)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](N)c1cccc(C)c1
Show InChI InChI=1S/C24H29FN6O3/c1-14-5-4-6-15(11-14)17(26)13-19(32)30-7-9-31(10-8-30)24-28-21-16(23(27)29-24)12-18(33-2)22(34-3)20(21)25/h4-6,11-12,17H,7-10,13,26H2,1-3H3,(H2,27,28,29)/t17-/m1/s1
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NOVARTIS AG

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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251392
PNG
(US9452990, 72 | US9452990, 79)
Show SMILES CN[C@H](CC(=O)N1CCN(CC1)c1nc(N)c2cc(OC)c(OC)c(F)c2n1)c1ccccc1
Show InChI InChI=1S/C24H29FN6O3/c1-27-17(15-7-5-4-6-8-15)14-19(32)30-9-11-31(12-10-30)24-28-21-16(23(26)29-24)13-18(33-2)22(34-3)20(21)25/h4-8,13,17,27H,9-12,14H2,1-3H3,(H2,26,28,29)/t17-/m1/s1
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NOVARTIS AG

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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251431
PNG
(US9452990, 113)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H]1CCCCN1
Show InChI InChI=1S/C21H29FN6O3/c1-30-15-12-14-18(17(22)19(15)31-2)25-21(26-20(14)23)28-9-7-27(8-10-28)16(29)11-13-5-3-4-6-24-13/h12-13,24H,3-11H2,1-2H3,(H2,23,25,26)/t13-/m0/s1
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NOVARTIS AG

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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251359
PNG
(US9452990, 39)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](N)c1ccccc1
Show InChI InChI=1S/C23H27FN6O3/c1-32-17-12-15-20(19(24)21(17)33-2)27-23(28-22(15)26)30-10-8-29(9-11-30)18(31)13-16(25)14-6-4-3-5-7-14/h3-7,12,16H,8-11,13,25H2,1-2H3,(H2,26,27,28)/t16-/m1/s1
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NOVARTIS AG

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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251331
PNG
(US9452990, 11)
Show SMILES COCCOc1c(F)c2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)\C=C\c1ccc(cc1)C#N
Show InChI InChI=1S/C26H27FN6O4/c1-35-13-14-37-24-20(36-2)15-19-23(22(24)27)30-26(31-25(19)29)33-11-9-32(10-12-33)21(34)8-7-17-3-5-18(16-28)6-4-17/h3-8,15H,9-14H2,1-2H3,(H2,29,30,31)/b8-7+
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NOVARTIS AG

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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251376
PNG
(US9452990, 56)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(C[C@@H]1C)C(=O)C[C@@H](N)CC(C)C
Show InChI InChI=1S/C22H33FN6O3/c1-12(2)8-14(24)9-17(30)28-6-7-29(13(3)11-28)22-26-19-15(21(25)27-22)10-16(31-4)20(32-5)18(19)23/h10,12-14H,6-9,11,24H2,1-5H3,(H2,25,26,27)/t13-,14-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251425
PNG
(US9452990, 107)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(C[C@@H]1c1ccccc1)C(=O)[C@@H]1CCc2ccccc2[C@@H]1N
Show InChI InChI=1S/C31H33FN6O3/c1-40-24-16-22-27(25(32)28(24)41-2)35-31(36-29(22)34)38-15-14-37(17-23(38)19-9-4-3-5-10-19)30(39)21-13-12-18-8-6-7-11-20(18)26(21)33/h3-11,16,21,23,26H,12-15,17,33H2,1-2H3,(H2,34,35,36)/t21-,23-,26+/m1/s1
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NOVARTIS AG

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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251374
PNG
(US9452990, 54)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](N)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H26F4N6O3/c1-36-17-11-15-20(19(25)21(17)37-2)31-23(32-22(15)30)34-8-6-33(7-9-34)18(35)12-16(29)13-4-3-5-14(10-13)24(26,27)28/h3-5,10-11,16H,6-9,12,29H2,1-2H3,(H2,30,31,32)/t16-/m1/s1
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251436
PNG
(US9452990, 118)
Show SMILES CCC[C@H]1CN(CCN1c1nc(N)c2cc(OC)c(OC)c(F)c2n1)C(=O)C[C@@H]1CCCN1
Show InChI InChI=1S/C23H33FN6O3/c1-4-6-15-13-29(18(31)11-14-7-5-8-26-14)9-10-30(15)23-27-20-16(22(25)28-23)12-17(32-2)21(33-3)19(20)24/h12,14-15,26H,4-11,13H2,1-3H3,(H2,25,27,28)/t14-,15-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251347
PNG
(US9452990, 27)
Show SMILES CCC[C@H]1CN(CCN1c1nc(N)c2cc(OC)c(OC)c(F)c2n1)C(=O)c1cc2cc(F)ccc2[nH]1
Show InChI InChI=1S/C26H28F2N6O3/c1-4-5-16-13-33(25(35)19-11-14-10-15(27)6-7-18(14)30-19)8-9-34(16)26-31-22-17(24(29)32-26)12-20(36-2)23(37-3)21(22)28/h6-7,10-12,16,30H,4-5,8-9,13H2,1-3H3,(H2,29,31,32)/t16-/m0/s1
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NOVARTIS AG

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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251355
PNG
(US9452990, 35)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](N)c1ccoc1
Show InChI InChI=1S/C21H25FN6O4/c1-30-15-9-13-18(17(22)19(15)31-2)25-21(26-20(13)24)28-6-4-27(5-7-28)16(29)10-14(23)12-3-8-32-11-12/h3,8-9,11,14H,4-7,10,23H2,1-2H3,(H2,24,25,26)/t14-/m1/s1
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251433
PNG
(US9452990, 115)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(C[C@@H]1C)C(=O)C[C@@H]1CCCN1
Show InChI InChI=1S/C21H29FN6O3/c1-12-11-27(16(29)9-13-5-4-6-24-13)7-8-28(12)21-25-18-14(20(23)26-21)10-15(30-2)19(31-3)17(18)22/h10,12-13,24H,4-9,11H2,1-3H3,(H2,23,25,26)/t12-,13-/m0/s1
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NOVARTIS AG

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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251337
PNG
(US9452990, 17)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C23H23FN6O3/c1-32-17-12-14-19(18(24)20(17)33-2)27-23(28-21(14)25)30-9-7-29(8-10-30)22(31)16-11-13-5-3-4-6-15(13)26-16/h3-6,11-12,26H,7-10H2,1-2H3,(H2,25,27,28)
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NOVARTIS AG

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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251430
PNG
(US9452990, 112)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)CC1NCc2ccccc12
Show InChI InChI=1S/C24H27FN6O3/c1-33-18-11-16-21(20(25)22(18)34-2)28-24(29-23(16)26)31-9-7-30(8-10-31)19(32)12-17-15-6-4-3-5-14(15)13-27-17/h3-6,11,17,27H,7-10,12-13H2,1-2H3,(H2,26,28,29)
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251429
PNG
(US9452990, 111)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H]1CC[C@@H](N1)c1ccccc1
Show InChI InChI=1S/C26H31FN6O3/c1-35-20-15-18-23(22(27)24(20)36-2)30-26(31-25(18)28)33-12-10-32(11-13-33)21(34)14-17-8-9-19(29-17)16-6-4-3-5-7-16/h3-7,15,17,19,29H,8-14H2,1-2H3,(H2,28,30,31)/t17-,19+/m0/s1
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251325
PNG
(US9452990, 5)
Show SMILES COc1cc2c(N)nc(nc2c(C#N)c1OC)N1CCN(CC1)C(=O)\C=C\C1CC1
Show InChI InChI=1S/C21H24N6O3/c1-29-16-11-14-18(15(12-22)19(16)30-2)24-21(25-20(14)23)27-9-7-26(8-10-27)17(28)6-5-13-3-4-13/h5-6,11,13H,3-4,7-10H2,1-2H3,(H2,23,24,25)/b6-5+
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n/an/a 440n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251370
PNG
(US9452990, 50)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](N)c1ccc(F)cc1F
Show InChI InChI=1S/C23H25F3N6O3/c1-34-17-10-14-20(19(26)21(17)35-2)29-23(30-22(14)28)32-7-5-31(6-8-32)18(33)11-16(27)13-4-3-12(24)9-15(13)25/h3-4,9-10,16H,5-8,11,27H2,1-2H3,(H2,28,29,30)/t16-/m1/s1
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251321
PNG
(US9452990, 1)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)\C=C\C1CC1
Show InChI InChI=1S/C20H24FN5O3/c1-28-14-11-13-17(16(21)18(14)29-2)23-20(24-19(13)22)26-9-7-25(8-10-26)15(27)6-5-12-3-4-12/h5-6,11-12H,3-4,7-10H2,1-2H3,(H2,22,23,24)/b6-5+
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251362
PNG
(US9452990, 42)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](N)c1ccc(cc1)C#C
Show InChI InChI=1S/C25H27FN6O3/c1-4-15-5-7-16(8-6-15)18(27)14-20(33)31-9-11-32(12-10-31)25-29-22-17(24(28)30-25)13-19(34-2)23(35-3)21(22)26/h1,5-8,13,18H,9-12,14,27H2,2-3H3,(H2,28,29,30)/t18-/m1/s1
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251399
PNG
(US9452990, 81)
Show SMILES COc1cc2c(N)nc(nc2c(Br)c1OC)N1CCN(CC1)C(=O)C[C@@H](N)c1ccccc1
Show InChI InChI=1S/C23H27BrN6O3/c1-32-17-12-15-20(19(24)21(17)33-2)27-23(28-22(15)26)30-10-8-29(9-11-30)18(31)13-16(25)14-6-4-3-5-7-14/h3-7,12,16H,8-11,13,25H2,1-2H3,(H2,26,27,28)/t16-/m1/s1
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NOVARTIS AG

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Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251434
PNG
(US9452990, 116)
Show SMILES CC[C@H]1CN(CCN1c1nc(N)c2cc(OC)c(OC)c(F)c2n1)C(=O)C[C@@H]1CCCN1
Show InChI InChI=1S/C22H31FN6O3/c1-4-14-12-28(17(30)10-13-6-5-7-25-13)8-9-29(14)22-26-19-15(21(24)27-22)11-16(31-2)20(32-3)18(19)23/h11,13-14,25H,4-10,12H2,1-3H3,(H2,24,26,27)/t13-,14-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251437
PNG
(US9452990, 119)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(C[C@@H]1c1ccccc1)C(=O)C[C@@H]1CCN1
Show InChI InChI=1S/C25H29FN6O3/c1-34-19-13-17-22(21(26)23(19)35-2)29-25(30-24(17)27)32-11-10-31(20(33)12-16-8-9-28-16)14-18(32)15-6-4-3-5-7-15/h3-7,13,16,18,28H,8-12,14H2,1-2H3,(H2,27,29,30)/t16-,18+/m0/s1
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251353
PNG
(US9452990, 33)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](N)CC(C)C
Show InChI InChI=1S/C21H31FN6O3/c1-12(2)9-13(23)10-16(29)27-5-7-28(8-6-27)21-25-18-14(20(24)26-21)11-15(30-3)19(31-4)17(18)22/h11-13H,5-10,23H2,1-4H3,(H2,24,25,26)/t13-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251447
PNG
(US9452990, 129)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](CN)c1ccccc1
Show InChI InChI=1S/C24H29FN6O3/c1-33-18-13-17-21(20(25)22(18)34-2)28-24(29-23(17)27)31-10-8-30(9-11-31)19(32)12-16(14-26)15-6-4-3-5-7-15/h3-7,13,16H,8-12,14,26H2,1-2H3,(H2,27,28,29)/t16-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251395
PNG
(US9452990, 75)
Show SMILES COc1cc2c(N)nc(nc2c(C#N)c1OC)N1CCN(CC1)C(=O)C[C@@H](N)c1ccccc1
Show InChI InChI=1S/C24H27N7O3/c1-33-19-12-16-21(17(14-25)22(19)34-2)28-24(29-23(16)27)31-10-8-30(9-11-31)20(32)13-18(26)15-6-4-3-5-7-15/h3-7,12,18H,8-11,13,26H2,1-2H3,(H2,27,28,29)/t18-/m1/s1
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251422
PNG
(US9452990, 104)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)[C@@H]1CCc2ccccc2[C@@H]1N
Show InChI InChI=1S/C25H29FN6O3/c1-34-18-13-17-21(19(26)22(18)35-2)29-25(30-23(17)28)32-11-9-31(10-12-32)24(33)16-8-7-14-5-3-4-6-15(14)20(16)27/h3-6,13,16,20H,7-12,27H2,1-2H3,(H2,28,29,30)/t16-,20+/m1/s1
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251435
PNG
(US9452990, 117)
Show SMILES CC[C@H]1CN(CCN1c1nc(N)c2cc(OC)c(OC)c(F)c2n1)C(=O)C[C@@H]1CCCCN1
Show InChI InChI=1S/C23H33FN6O3/c1-4-15-13-29(18(31)11-14-7-5-6-8-26-14)9-10-30(15)23-27-20-16(22(25)28-23)12-17(32-2)21(33-3)19(20)24/h12,14-15,26H,4-11,13H2,1-3H3,(H2,25,27,28)/t14-,15-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251441
PNG
(US9452990, 123)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(C[C@@H]1c1ccccc1)C(=O)CC1CNCCO1
Show InChI InChI=1S/C26H31FN6O4/c1-35-20-13-18-23(22(27)24(20)36-2)30-26(31-25(18)28)33-10-9-32(15-19(33)16-6-4-3-5-7-16)21(34)12-17-14-29-8-11-37-17/h3-7,13,17,19,29H,8-12,14-15H2,1-2H3,(H2,28,30,31)/t17?,19-/m1/s1
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251400
PNG
(US9452990, 82)
Show SMILES COc1cc2c(N)nc(nc2c(Cl)c1OC)N1CCN(CC1)C(=O)C[C@@H](N)c1ccc(F)cc1
Show InChI InChI=1S/C23H26ClFN6O3/c1-33-17-11-15-20(19(24)21(17)34-2)28-23(29-22(15)27)31-9-7-30(8-10-31)18(32)12-16(26)13-3-5-14(25)6-4-13/h3-6,11,16H,7-10,12,26H2,1-2H3,(H2,27,28,29)/t16-/m1/s1
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n/an/a 1.02E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251351
PNG
(US9452990, 31)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H](N)CC#C
Show InChI InChI=1S/C20H25FN6O3/c1-4-5-12(22)10-15(28)26-6-8-27(9-7-26)20-24-17-13(19(23)25-20)11-14(29-2)18(30-3)16(17)21/h1,11-12H,5-10,22H2,2-3H3,(H2,23,24,25)/t12-/m0/s1
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n/an/a 1.04E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251333
PNG
(US9452990, 13)
Show SMILES COc1cc2c(N)nc(nc2c(Cl)c1OC)N1CCN(CC1)C(=O)\C=C\C1CC1
Show InChI InChI=1S/C20H24ClN5O3/c1-28-14-11-13-17(16(21)18(14)29-2)23-20(24-19(13)22)26-9-7-25(8-10-26)15(27)6-5-12-3-4-12/h5-6,11-12H,3-4,7-10H2,1-2H3,(H2,22,23,24)/b6-5+
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n/an/a 1.05E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251423
PNG
(US9452990, 105)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(C[C@@H]1C)C(=O)[C@@H]1CCc2ccccc2[C@@H]1N
Show InChI InChI=1S/C26H31FN6O3/c1-14-13-32(25(34)17-9-8-15-6-4-5-7-16(15)21(17)28)10-11-33(14)26-30-22-18(24(29)31-26)12-19(35-2)23(36-3)20(22)27/h4-7,12,14,17,21H,8-11,13,28H2,1-3H3,(H2,29,30,31)/t14-,17+,21-/m0/s1
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n/an/a 1.07E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251335
PNG
(US9452990, 15)
Show SMILES COc1cc2c(N)nc(nc2c(Br)c1OC)N1CCN(CC1)C(=O)\C=C\C1CC1
Show InChI InChI=1S/C20H24BrN5O3/c1-28-14-11-13-17(16(21)18(14)29-2)23-20(24-19(13)22)26-9-7-25(8-10-26)15(27)6-5-12-3-4-12/h5-6,11-12H,3-4,7-10H2,1-2H3,(H2,22,23,24)/b6-5+
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n/an/a 1.28E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251336
PNG
(US9452990, 16)
Show SMILES COc1cc2c(N)nc(nc2c(Cl)c1OC)N1CCN(CC1)C(=O)\C=C\c1ccc(F)cc1
Show InChI InChI=1S/C23H23ClFN5O3/c1-32-17-13-16-20(19(24)21(17)33-2)27-23(28-22(16)26)30-11-9-29(10-12-30)18(31)8-5-14-3-6-15(25)7-4-14/h3-8,13H,9-12H2,1-2H3,(H2,26,27,28)/b8-5+
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NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251323
PNG
(US9452990, 3)
Show SMILES COC[C@H]1CN(CCN1c1nc(N)c2cc(OC)c(OC)c(F)c2n1)C(=O)\C=C\C1CC1
Show InChI InChI=1S/C22H28FN5O4/c1-30-12-14-11-27(17(29)7-6-13-4-5-13)8-9-28(14)22-25-19-15(21(24)26-22)10-16(31-2)20(32-3)18(19)23/h6-7,10,13-14H,4-5,8-9,11-12H2,1-3H3,(H2,24,25,26)/b7-6+/t14-/m1/s1
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n/an/a 2.06E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


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More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251382
PNG
(US9452990, 62)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(C[C@@H]1C)C(=O)C[C@@H](N)Cc1ccccc1
Show InChI InChI=1S/C25H31FN6O3/c1-15-14-31(20(33)12-17(27)11-16-7-5-4-6-8-16)9-10-32(15)25-29-22-18(24(28)30-25)13-19(34-2)23(35-3)21(22)26/h4-8,13,15,17H,9-12,14,27H2,1-3H3,(H2,28,29,30)/t15-,17-/m0/s1
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US Patent
n/an/a 2.25E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251424
PNG
(US9452990, 106)
Show SMILES CC[C@H]1CN(CCN1c1nc(N)c2cc(OC)c(OC)c(F)c2n1)C(=O)[C@@H]1CCc2ccccc2[C@@H]1N
Show InChI InChI=1S/C27H33FN6O3/c1-4-16-14-33(26(35)18-10-9-15-7-5-6-8-17(15)22(18)29)11-12-34(16)27-31-23-19(25(30)32-27)13-20(36-2)24(37-3)21(23)28/h5-8,13,16,18,22H,4,9-12,14,29H2,1-3H3,(H2,30,31,32)/t16-,18+,22-/m0/s1
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US Patent
n/an/a 2.66E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251444
PNG
(US9452990, 126)
Show SMILES COc1cc2c(N)nc(nc2c(C#N)c1OC)N1CCN(CC1)C(=O)C[C@@H]1CCCCN1
Show InChI InChI=1S/C22H29N7O3/c1-31-17-12-15-19(16(13-23)20(17)32-2)26-22(27-21(15)24)29-9-7-28(8-10-29)18(30)11-14-5-3-4-6-25-14/h12,14,25H,3-11H2,1-2H3,(H2,24,26,27)/t14-/m0/s1
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US Patent
n/an/a 2.90E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251334
PNG
(US9452990, 14)
Show SMILES COc1cc2nc(nc(N)c2c(Cl)c1OC)N1CCN(CC1)C(=O)\C=C\C1CC1
Show InChI InChI=1S/C20H24ClN5O3/c1-28-14-11-13-16(17(21)18(14)29-2)19(22)24-20(23-13)26-9-7-25(8-10-26)15(27)6-5-12-3-4-12/h5-6,11-12H,3-4,7-10H2,1-2H3,(H2,22,23,24)/b6-5+
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US Patent
n/an/a 3.29E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251432
PNG
(US9452990, 114)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H]1CCCNC1
Show InChI InChI=1S/C21H29FN6O3/c1-30-15-11-14-18(17(22)19(15)31-2)25-21(26-20(14)23)28-8-6-27(7-9-28)16(29)10-13-4-3-5-24-12-13/h11,13,24H,3-10,12H2,1-2H3,(H2,23,25,26)/t13-/m0/s1
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US Patent
n/an/a 3.87E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251427
PNG
(US9452990, 109)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H]1CCN1
Show InChI InChI=1S/C19H25FN6O3/c1-28-13-10-12-16(15(20)17(13)29-2)23-19(24-18(12)21)26-7-5-25(6-8-26)14(27)9-11-3-4-22-11/h10-11,22H,3-9H2,1-2H3,(H2,21,23,24)/t11-/m0/s1
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n/an/a 4.27E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251442
PNG
(US9452990, 124)
Show SMILES COCCOc1c(F)c2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)C[C@@H]1CCCN1
Show InChI InChI=1S/C22H31FN6O4/c1-31-10-11-33-20-16(32-2)13-15-19(18(20)23)26-22(27-21(15)24)29-8-6-28(7-9-29)17(30)12-14-4-3-5-25-14/h13-14,25H,3-12H2,1-2H3,(H2,24,26,27)/t14-/m0/s1
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US Patent
n/an/a 5.95E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251383
PNG
(US9452990, 63)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(C[C@@H]1C)C(=O)C[C@@H](N)Cc1ccncc1
Show InChI InChI=1S/C24H30FN7O3/c1-14-13-31(19(33)11-16(26)10-15-4-6-28-7-5-15)8-9-32(14)24-29-21-17(23(27)30-24)12-18(34-2)22(35-3)20(21)25/h4-7,12,14,16H,8-11,13,26H2,1-3H3,(H2,27,29,30)/t14-,16-/m0/s1
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US Patent
n/an/a 7.32E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251340
PNG
(US9452990, 20)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)c1cc2c(OC)cccc2[nH]1
Show InChI InChI=1S/C24H25FN6O4/c1-33-17-6-4-5-15-13(17)11-16(27-15)23(32)30-7-9-31(10-8-30)24-28-20-14(22(26)29-24)12-18(34-2)21(35-3)19(20)25/h4-6,11-12,27H,7-10H2,1-3H3,(H2,26,28,29)
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US Patent
n/an/a 9.63E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251443
PNG
(US9452990, 125)
Show SMILES COCCOc1c(F)c2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)C[C@@H]1CCCCN1
Show InChI InChI=1S/C23H33FN6O4/c1-32-11-12-34-21-17(33-2)14-16-20(19(21)24)27-23(28-22(16)25)30-9-7-29(8-10-30)18(31)13-15-5-3-4-6-26-15/h14-15,26H,3-13H2,1-2H3,(H2,25,27,28)/t15-/m0/s1
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US Patent
n/an/a 9.95E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251324
PNG
(US9452990, 4)
Show SMILES COCCC1CN(CCN1c1nc(N)c2cc(OC)c(OC)c(F)c2n1)C(=O)\C=C\C1CC1
Show InChI InChI=1S/C23H30FN5O4/c1-31-11-8-15-13-28(18(30)7-6-14-4-5-14)9-10-29(15)23-26-20-16(22(25)27-23)12-17(32-2)21(33-3)19(20)24/h6-7,12,14-15H,4-5,8-11,13H2,1-3H3,(H2,25,26,27)/b7-6+
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US Patent
n/an/a 1.65E+4n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%