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Patent code US9453023

Compile Data Set for Download or QSAR
Found 39 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM247467
PNG
(US9453023, 26)
Show SMILES C[C@H]1CCCN1C1CC[C@@H](C1)c1ccc(NC(=O)c2c(C)noc2C)cc1
Show InChI InChI=1S/C22H29N3O2/c1-14-5-4-12-25(14)20-11-8-18(13-20)17-6-9-19(10-7-17)23-22(26)21-15(2)24-27-16(21)3/h6-7,9-10,14,18,20H,4-5,8,11-13H2,1-3H3,(H,23,26)/t14-,18-,20?/m0/s1
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6.01n/an/an/an/an/an/an/an/a



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Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


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More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM247449
PNG
(US9453023, 8)
Show SMILES CC1CCCN1C1CC[C@@H](C1)c1ccc(cc1)N1CCCC2(CCNCC2)C1=O
Show InChI InChI=1S/C25H37N3O/c1-19-4-2-16-27(19)23-10-7-21(18-23)20-5-8-22(9-6-20)28-17-3-11-25(24(28)29)12-14-26-15-13-25/h5-6,8-9,19,21,23,26H,2-4,7,10-18H2,1H3/t19?,21-,23?/m0/s1
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Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


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More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM247453
PNG
(US9453023, 12)
Show SMILES C[C@H]1CCCN1[C@H]1CC[C@@H](CC1)c1ccc(cc1)N1CCC2(CCOCC2)C1=O
Show InChI InChI=1S/C25H36N2O2/c1-19-3-2-15-26(19)22-8-4-20(5-9-22)21-6-10-23(11-7-21)27-16-12-25(24(27)28)13-17-29-18-14-25/h6-7,10-11,19-20,22H,2-5,8-9,12-18H2,1H3/t19-,20-,22-/m0/s1
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Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


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More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM247455
PNG
(US9453023, 14)
Show SMILES C[C@@H]1CCCN1[C@H]1CC[C@@H](CC1)c1ccc(N2CCC3(CCN(CC3)C(=O)OC(C)(C)C)C2=O)c(F)c1
Show InChI InChI=1S/C30H44FN3O3/c1-21-6-5-16-33(21)24-10-7-22(8-11-24)23-9-12-26(25(31)20-23)34-19-15-30(27(34)35)13-17-32(18-14-30)28(36)37-29(2,3)4/h9,12,20-22,24H,5-8,10-11,13-19H2,1-4H3/t21-,22-,24-/m1/s1
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Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


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More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM247462
PNG
(US9453023, 21)
Show SMILES C[C@H]1CCCN1C1CCC(=CC1)c1ccc(NC(=O)OCc2ccccc2)c(F)c1
Show InChI InChI=1S/C25H29FN2O2/c1-18-6-5-15-28(18)22-12-9-20(10-13-22)21-11-14-24(23(26)16-21)27-25(29)30-17-19-7-3-2-4-8-19/h2-4,7-9,11,14,16,18,22H,5-6,10,12-13,15,17H2,1H3,(H,27,29)/t18-,22?/m0/s1
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Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


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More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM247459
PNG
(US9453023, 18)
Show SMILES C[C@@H]1CCCN1[C@H]1CC[C@@H](CC1)c1ccc(N2CCC3(CCNCC3)C2=O)c(F)c1
Show InChI InChI=1S/C25H36FN3O/c1-18-3-2-15-28(18)21-7-4-19(5-8-21)20-6-9-23(22(26)17-20)29-16-12-25(24(29)30)10-13-27-14-11-25/h6,9,17-19,21,27H,2-5,7-8,10-16H2,1H3/t18-,19-,21-/m1/s1
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Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


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More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM247442
PNG
(US9453023, 1)
Show SMILES C[C@H]1CCCN1C1CC[C@@H](C1)c1ccc(cc1)N1CCC2(CCOCC2)C1=O
Show InChI InChI=1S/C24H34N2O2/c1-18-3-2-13-25(18)22-9-6-20(17-22)19-4-7-21(8-5-19)26-14-10-24(23(26)27)11-15-28-16-12-24/h4-5,7-8,18,20,22H,2-3,6,9-17H2,1H3/t18-,20-,22?/m0/s1
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Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


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More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM247465
PNG
(US9453023, 24)
Show SMILES C[C@H]1CCCN1C1CC[C@@H](C1)c1ccc(NS(=O)(=O)c2ccc(F)cc2)cc1
Show InChI InChI=1S/C22H27FN2O2S/c1-16-3-2-14-25(16)21-11-6-18(15-21)17-4-9-20(10-5-17)24-28(26,27)22-12-7-19(23)8-13-22/h4-5,7-10,12-13,16,18,21,24H,2-3,6,11,14-15H2,1H3/t16-,18-,21?/m0/s1
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Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


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More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM247443
PNG
(US9453023, 2)
Show SMILES C[C@H]1CCCN1C1CC[C@@H](C1)c1ccc(cc1)N1CCC2(CCCCC2)C1=O
Show InChI InChI=1S/C25H36N2O/c1-19-6-5-16-26(19)23-12-9-21(18-23)20-7-10-22(11-8-20)27-17-15-25(24(27)28)13-3-2-4-14-25/h7-8,10-11,19,21,23H,2-6,9,12-18H2,1H3/t19-,21-,23?/m0/s1
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Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


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More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM247444
PNG
(US9453023, 3)
Show SMILES CC1CCCN1C1CC[C@@H](C1)c1ccc(cc1)N1CCCC2(CCN(CC2)C(=O)OC(C)(C)C)C1=O
Show InChI InChI=1S/C30H45N3O3/c1-22-7-5-17-32(22)26-13-10-24(21-26)23-8-11-25(12-9-23)33-18-6-14-30(27(33)34)15-19-31(20-16-30)28(35)36-29(2,3)4/h8-9,11-12,22,24,26H,5-7,10,13-21H2,1-4H3/t22?,24-,26?/m0/s1
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Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


Citation and Details
More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM247447
PNG
(US9453023, 6)
Show SMILES CC1CCCN1C1CC[C@@H](C1)c1ccc(cc1)N1CCC2(CCN(CC2)C(=O)OC(C)(C)C)C1=O
Show InChI InChI=1S/C29H43N3O3/c1-21-6-5-16-31(21)25-12-9-23(20-25)22-7-10-24(11-8-22)32-19-15-29(26(32)33)13-17-30(18-14-29)27(34)35-28(2,3)4/h7-8,10-11,21,23,25H,5-6,9,12-20H2,1-4H3/t21?,23-,25?/m0/s1
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Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


Citation and Details
More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM247471
PNG
(US9453023, 30)
Show SMILES C[C@H]1CCCN1C1CC[C@@H](C1)c1ccc(NS(=O)(=O)c2ccc(F)c(F)c2)cc1
Show InChI InChI=1S/C22H26F2N2O2S/c1-15-3-2-12-26(15)19-9-6-17(13-19)16-4-7-18(8-5-16)25-29(27,28)20-10-11-21(23)22(24)14-20/h4-5,7-8,10-11,14-15,17,19,25H,2-3,6,9,12-13H2,1H3/t15-,17-,19?/m0/s1
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Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


Citation and Details
More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM247448
PNG
(US9453023, 7)
Show SMILES CC1CCCN1C1CC[C@@H](C1)c1ccc(cc1)N1CCCC2(CCCC2)C1=O
Show InChI InChI=1S/C25H36N2O/c1-19-6-4-16-26(19)23-12-9-21(18-23)20-7-10-22(11-8-20)27-17-5-15-25(24(27)28)13-2-3-14-25/h7-8,10-11,19,21,23H,2-6,9,12-18H2,1H3/t19?,21-,23?/m0/s1
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Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


Citation and Details
More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM247474
PNG
(US9453023, 33)
Show SMILES C[C@H]1CCCN1C1CC[C@@H](C1)c1ccc(NC(=O)c2ccccc2C)cc1
Show InChI InChI=1S/C24H30N2O/c1-17-6-3-4-8-23(17)24(27)25-21-12-9-19(10-13-21)20-11-14-22(16-20)26-15-5-7-18(26)2/h3-4,6,8-10,12-13,18,20,22H,5,7,11,14-16H2,1-2H3,(H,25,27)/t18-,20-,22?/m0/s1
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Sanofi

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Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


Citation and Details
More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM247469
PNG
(US9453023, 28)
Show SMILES C[C@H]1CCCN1C1CC[C@@H](C1)c1ccc(NC(=O)C2CCOCC2)cc1
Show InChI InChI=1S/C22H32N2O2/c1-16-3-2-12-24(16)21-9-6-19(15-21)17-4-7-20(8-5-17)23-22(25)18-10-13-26-14-11-18/h4-5,7-8,16,18-19,21H,2-3,6,9-15H2,1H3,(H,23,25)/t16-,19-,21?/m0/s1
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Sanofi

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Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


Citation and Details
More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM247468
PNG
(US9453023, 27)
Show SMILES C[C@H]1CCCN1C1CC[C@@H](C1)c1ccc(NS(=O)(=O)C2CC2)cc1
Show InChI InChI=1S/C19H28N2O2S/c1-14-3-2-12-21(14)18-9-6-16(13-18)15-4-7-17(8-5-15)20-24(22,23)19-10-11-19/h4-5,7-8,14,16,18-20H,2-3,6,9-13H2,1H3/t14-,16-,18?/m0/s1
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Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


Citation and Details
More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM247472
PNG
(US9453023, 31)
Show SMILES C[C@H]1CCCN1C1CC[C@@H](C1)c1ccc(NC(=O)c2ccc(F)cc2)cc1
Show InChI InChI=1S/C23H27FN2O/c1-16-3-2-14-26(16)22-13-8-19(15-22)17-6-11-21(12-7-17)25-23(27)18-4-9-20(24)10-5-18/h4-7,9-12,16,19,22H,2-3,8,13-15H2,1H3,(H,25,27)/t16-,19-,22?/m0/s1
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Sanofi

US Patent


Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


Citation and Details
More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM247451
PNG
(US9453023, 10)
Show SMILES C[C@@H]1CCCN1[C@H]1CC[C@@H](CC1)c1ccc(cc1)N1CCC2(CCOCC2)C1=O
Show InChI InChI=1S/C25H36N2O2/c1-19-3-2-15-26(19)22-8-4-20(5-9-22)21-6-10-23(11-7-21)27-16-12-25(24(27)28)13-17-29-18-14-25/h6-7,10-11,19-20,22H,2-5,8-9,12-18H2,1H3/t19-,20-,22-/m1/s1
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Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


Citation and Details
More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM247441
PNG
(US9453023, Intermediate (13))
Show SMILES C[C@@H]1CCCN1C1CC[C@H](C1)c1ccc(NC(=O)OCc2ccccc2)cc1
Show InChI InChI=1S/C24H30N2O2/c1-18-6-5-15-26(18)23-14-11-21(16-23)20-9-12-22(13-10-20)25-24(27)28-17-19-7-3-2-4-8-19/h2-4,7-10,12-13,18,21,23H,5-6,11,14-17H2,1H3,(H,25,27)/t18-,21-,23?/m1/s1
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Sanofi

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Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


Citation and Details
More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM247452
PNG
(US9453023, 11)
Show SMILES C[C@H]1CCCCN1[C@H]1CC[C@@H](CC1)c1ccc(cc1)N1CCC2(CCOCC2)C1=O
Show InChI InChI=1S/C26H38N2O2/c1-20-4-2-3-16-27(20)23-9-5-21(6-10-23)22-7-11-24(12-8-22)28-17-13-26(25(28)29)14-18-30-19-15-26/h7-8,11-12,20-21,23H,2-6,9-10,13-19H2,1H3/t20-,21-,23-/m0/s1
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Sanofi

US Patent


Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


Citation and Details
More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM247446
PNG
(US9453023, 5)
Show InChI InChI=1S/C27H38N2O3/c1-19-4-3-16-28(19)24-10-7-22(18-24)20-5-8-23(9-6-20)29-17-15-27(26(29)31)13-11-21(12-14-27)25(30)32-2/h5-6,8-9,19,21-22,24H,3-4,7,10-18H2,1-2H3/t19?,21?,22-,24?,27?/m0/s1
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Sanofi

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Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


Citation and Details
More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM247457
PNG
(US9453023, 16)
Show SMILES C[C@H]1CCCN1[C@H]1CC[C@@H](CC1)c1ccc(N2CCC3(CCN(CC3)C(=O)OC(C)(C)C)C2=O)c(F)c1
Show InChI InChI=1S/C30H44FN3O3/c1-21-6-5-16-33(21)24-10-7-22(8-11-24)23-9-12-26(25(31)20-23)34-19-15-30(27(34)35)13-17-32(18-14-30)28(36)37-29(2,3)4/h9,12,20-22,24H,5-8,10-11,13-19H2,1-4H3/t21-,22-,24-/m0/s1
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44.2n/an/an/an/an/an/an/an/a



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Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


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More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM247466
PNG
(US9453023, 25)
Show SMILES C[C@H]1CCCN1C1CC[C@@H](C1)c1ccc(NOc2cc(F)ccc2C)cc1
Show InChI InChI=1S/C23H29FN2O/c1-16-5-9-20(24)15-23(16)27-25-21-10-6-18(7-11-21)19-8-12-22(14-19)26-13-3-4-17(26)2/h5-7,9-11,15,17,19,22,25H,3-4,8,12-14H2,1-2H3/t17-,19-,22?/m0/s1
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45.7n/an/an/an/an/an/an/an/a



Sanofi

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Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


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More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM247464
PNG
(US9453023, 23)
Show SMILES C[C@H]1CCCN1C1CC[C@@H](C1)c1ccc(NC(=O)c2cccs2)cc1
Show InChI InChI=1S/C21H26N2OS/c1-15-4-2-12-23(15)19-11-8-17(14-19)16-6-9-18(10-7-16)22-21(24)20-5-3-13-25-20/h3,5-7,9-10,13,15,17,19H,2,4,8,11-12,14H2,1H3,(H,22,24)/t15-,17-,19?/m0/s1
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46.5n/an/an/an/an/an/an/an/a



Sanofi

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Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


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More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM247477
PNG
(US9453023, 36)
Show SMILES C[C@H]1CCCN1C1CC[C@@H](C1)c1ccc(NC(=O)c2ccc(OC(F)(F)F)cc2)cc1
Show InChI InChI=1S/C24H27F3N2O2/c1-16-3-2-14-29(16)21-11-6-19(15-21)17-4-9-20(10-5-17)28-23(30)18-7-12-22(13-8-18)31-24(25,26)27/h4-5,7-10,12-13,16,19,21H,2-3,6,11,14-15H2,1H3,(H,28,30)/t16-,19-,21?/m0/s1
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48.5n/an/an/an/an/an/an/an/a



Sanofi

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Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


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More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM247440
PNG
(US9453023, Intermediate (10))
Show SMILES CC1CCCN1C1CC[C@@H](C1)c1ccc(NC(=O)OCc2ccccc2)cc1
Show InChI InChI=1S/C24H30N2O2/c1-18-6-5-15-26(18)23-14-11-21(16-23)20-9-12-22(13-10-20)25-24(27)28-17-19-7-3-2-4-8-19/h2-4,7-10,12-13,18,21,23H,5-6,11,14-17H2,1H3,(H,25,27)/t18?,21-,23?/m0/s1
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65.4n/an/an/an/an/an/an/an/a



Sanofi

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Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


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More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM247473
PNG
(US9453023, 32)
Show SMILES C[C@H]1CCCN1C1CC[C@@H](C1)c1ccc(NC(=O)c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C23H27ClN2O/c1-16-3-2-14-26(16)22-13-8-19(15-22)17-6-11-21(12-7-17)25-23(27)18-4-9-20(24)10-5-18/h4-7,9-12,16,19,22H,2-3,8,13-15H2,1H3,(H,25,27)/t16-,19-,22?/m0/s1
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Sanofi

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Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


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More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM247478
PNG
(US9453023, 37)
Show SMILES C[C@H]1CCCN1C1CC[C@@H](C1)c1ccc(NC(=O)Cc2ccccc2)cc1
Show InChI InChI=1S/C24H30N2O/c1-18-6-5-15-26(18)23-14-11-21(17-23)20-9-12-22(13-10-20)25-24(27)16-19-7-3-2-4-8-19/h2-4,7-10,12-13,18,21,23H,5-6,11,14-17H2,1H3,(H,25,27)/t18-,21-,23?/m0/s1
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71.4n/an/an/an/an/an/an/an/a



Sanofi

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Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


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More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM247445
PNG
(US9453023, 4)
Show SMILES CC1CCCN1C1CC[C@@H](C1)c1ccc(cc1)N1CCC2(CCC(O)CC2)C1=O
Show InChI InChI=1S/C25H36N2O2/c1-18-3-2-15-26(18)22-9-6-20(17-22)19-4-7-21(8-5-19)27-16-14-25(24(27)29)12-10-23(28)11-13-25/h4-5,7-8,18,20,22-23,28H,2-3,6,9-17H2,1H3/t18?,20-,22?,23?,25?/m0/s1
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75.2n/an/an/an/an/an/an/an/a



Sanofi

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Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


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More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM247470
PNG
(US9453023, 29)
Show SMILES C[C@H]1CCCN1C1CC[C@@H](C1)c1ccc(NC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C23H28N2O/c1-17-6-5-15-25(17)22-14-11-20(16-22)18-9-12-21(13-10-18)24-23(26)19-7-3-2-4-8-19/h2-4,7-10,12-13,17,20,22H,5-6,11,14-16H2,1H3,(H,24,26)/t17-,20-,22?/m0/s1
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Sanofi

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Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


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More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM247460
PNG
(US9453023, 19)
Show SMILES Fc1cc(ccc1N1CCC2(CCNCC2)C1=O)[C@H]1CC[C@@H](CC1)N1CCC1
Show InChI InChI=1S/C23H32FN3O/c24-20-16-18(17-2-5-19(6-3-17)26-13-1-14-26)4-7-21(20)27-15-10-23(22(27)28)8-11-25-12-9-23/h4,7,16-17,19,25H,1-3,5-6,8-15H2/t17-,19-
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Sanofi

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Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


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More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM247458
PNG
(US9453023, 17)
Show SMILES C[C@H]1CCCN1[C@H]1CC[C@@H](CC1)c1ccc(N2CCC3(CCNCC3)C2=O)c(F)c1
Show InChI InChI=1S/C25H36FN3O/c1-18-3-2-15-28(18)21-7-4-19(5-8-21)20-6-9-23(22(26)17-20)29-16-12-25(24(29)30)10-13-27-14-11-25/h6,9,17-19,21,27H,2-5,7-8,10-16H2,1H3/t18-,19-,21-/m0/s1
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Sanofi

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Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


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More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM247475
PNG
(US9453023, 34)
Show SMILES C[C@H]1CCCN1C1CC[C@@H](C1)c1ccc(NC(=O)c2ccc(C)cc2)cc1
Show InChI InChI=1S/C24H30N2O/c1-17-5-7-20(8-6-17)24(27)25-22-12-9-19(10-13-22)21-11-14-23(16-21)26-15-3-4-18(26)2/h5-10,12-13,18,21,23H,3-4,11,14-16H2,1-2H3,(H,25,27)/t18-,21-,23?/m0/s1
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Sanofi

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Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


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More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM247450
PNG
(US9453023, 9)
Show SMILES O=C1N(CCC11CCOCC1)c1ccc(cc1)[C@H]1CC[C@@H](CC1)N1CCCC1
Show InChI InChI=1S/C24H34N2O2/c27-23-24(12-17-28-18-13-24)11-16-26(23)22-9-5-20(6-10-22)19-3-7-21(8-4-19)25-14-1-2-15-25/h5-6,9-10,19,21H,1-4,7-8,11-18H2/t19-,21-
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Sanofi

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Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


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More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM247463
PNG
(US9453023, 22)
Show SMILES C[C@H]1CCCN1C1CC[C@@H](C1)c1ccc(NC(=O)C2CCN(CC2)C(C)=O)cc1
Show InChI InChI=1S/C24H35N3O2/c1-17-4-3-13-27(17)23-10-7-21(16-23)19-5-8-22(9-6-19)25-24(29)20-11-14-26(15-12-20)18(2)28/h5-6,8-9,17,20-21,23H,3-4,7,10-16H2,1-2H3,(H,25,29)/t17-,21-,23?/m0/s1
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Sanofi

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Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


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More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM247476
PNG
(US9453023, 35)
Show SMILES C[C@H]1CCCN1C1CC[C@@H](C1)c1ccc(NC(=O)c2ccccc2OC(F)(F)F)cc1
Show InChI InChI=1S/C24H27F3N2O2/c1-16-5-4-14-29(16)20-13-10-18(15-20)17-8-11-19(12-9-17)28-23(30)21-6-2-3-7-22(21)31-24(25,26)27/h2-3,6-9,11-12,16,18,20H,4-5,10,13-15H2,1H3,(H,28,30)/t16-,18-,20?/m0/s1
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Sanofi

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Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


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More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM247461
PNG
(US9453023, 20)
Show SMILES Fc1cc(ccc1N1CCC2(CCNCC2)C1=O)[C@H]1CC[C@@H](CC1)N1CCCC1
Show InChI InChI=1S/C24H34FN3O/c25-21-17-19(18-3-6-20(7-4-18)27-14-1-2-15-27)5-8-22(21)28-16-11-24(23(28)29)9-12-26-13-10-24/h5,8,17-18,20,26H,1-4,6-7,9-16H2/t18-,20-
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137n/an/an/an/an/an/an/an/a



Sanofi

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Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


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More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM247456
PNG
(US9453023, 15)
Show SMILES CC(C)(C)OC(=O)N1CCC2(CCN(C2=O)c2ccc(cc2F)[C@H]2CC[C@@H](CC2)N2CCC2)CC1
Show InChI InChI=1S/C28H40FN3O3/c1-27(2,3)35-26(34)31-16-11-28(12-17-31)13-18-32(25(28)33)24-10-7-21(19-23(24)29)20-5-8-22(9-6-20)30-14-4-15-30/h7,10,19-20,22H,4-6,8-9,11-18H2,1-3H3/t20-,22-
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Sanofi

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Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


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More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM247454
PNG
(US9453023, 13)
Show SMILES CC(C)(C)OC(=O)N1CCC2(CCN(C2=O)c2ccc(cc2F)[C@H]2CC[C@@H](CC2)N2CCCC2)CC1
Show InChI InChI=1S/C29H42FN3O3/c1-28(2,3)36-27(35)32-17-12-29(13-18-32)14-19-33(26(29)34)25-11-8-22(20-24(25)30)21-6-9-23(10-7-21)31-15-4-5-16-31/h8,11,20-21,23H,4-7,9-10,12-19H2,1-3H3/t21-,23-
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Sanofi

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Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


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Ligand-Target Pair
* indicates data uncertainty>20%