BindingDB logo
myBDB logout

Patent code US9453031

Compile Data Set for Download or QSAR

Found 272 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM251623
PNG
(US9453031, 46)
Show SMILES COc1cc(-c2nc3N4CCOC[C@H]4COc3c(n2)C(C)(C)O)c2cc[nH]c2c1
Show InChI InChI=1S/C21H24N4O4/c1-21(2,26)18-17-20(25-6-7-28-10-12(25)11-29-17)24-19(23-18)15-8-13(27-3)9-16-14(15)4-5-22-16/h4-5,8-9,12,22,26H,6-7,10-11H2,1-3H3/t12-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 38n/an/an/an/an/an/a



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM251621
PNG
(US9453031, 44)
Show SMILES CC(C)(O)c1nc(nc2N3CCOC[C@H]3COc12)-c1cccc2[nH]ccc12
Show InChI InChI=1S/C20H22N4O3/c1-20(2,25)17-16-19(24-8-9-26-10-12(24)11-27-16)23-18(22-17)14-4-3-5-15-13(14)6-7-21-15/h3-7,12,21,25H,8-11H2,1-2H3/t12-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 44n/an/an/an/an/an/a



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM251635
PNG
(US9453031, 72)
Show SMILES COc1cc(-c2nc3N4CCOC[C@H]4COc3c(n2)C(C)(C)S(C)(=O)=O)c2cc[nH]c2c1
Show InChI InChI=1S/C22H26N4O5S/c1-22(2,32(4,27)28)19-18-21(26-7-8-30-11-13(26)12-31-18)25-20(24-19)16-9-14(29-3)10-17-15(16)5-6-23-17/h5-6,9-10,13,23H,7-8,11-12H2,1-4H3/t13-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 45.3n/an/an/an/an/an/a



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM251641
PNG
(US9453031, 78)
Show SMILES COc1cc(-c2nc3N4CCOC[C@H]4COc3c(n2)C2(CCC2)S(C)(=O)=O)c2cc[nH]c2c1
Show InChI InChI=1S/C23H26N4O5S/c1-30-15-10-17(16-4-7-24-18(16)11-15)21-25-20(23(5-3-6-23)33(2,28)29)19-22(26-21)27-8-9-31-12-14(27)13-32-19/h4,7,10-11,14,24H,3,5-6,8-9,12-13H2,1-2H3/t14-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 47n/an/an/an/an/an/a



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM251622
PNG
(US9453031, 45)
Show SMILES CC(C)(O)c1nc(nc2N3CCOC[C@H]3COc12)-c1cc(F)cc2[nH]ccc12
Show InChI InChI=1S/C20H21FN4O3/c1-20(2,26)17-16-19(25-5-6-27-9-12(25)10-28-16)24-18(23-17)14-7-11(21)8-15-13(14)3-4-22-15/h3-4,7-8,12,22,26H,5-6,9-10H2,1-2H3/t12-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 53n/an/an/an/an/an/a



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM251652
PNG
(US9453031, 103)
Show SMILES Cc1cc2c(cccc2[nH]1)-c1nc2N3CCOC[C@H]3COc2c(n1)C(C)(C)S(C)(=O)=O
Show InChI InChI=1S/C22H26N4O4S/c1-13-10-16-15(6-5-7-17(16)23-13)20-24-19(22(2,3)31(4,27)28)18-21(25-20)26-8-9-29-11-14(26)12-30-18/h5-7,10,14,23H,8-9,11-12H2,1-4H3/t14-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 58n/an/an/an/an/an/a



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM251638
PNG
(US9453031, 75)
Show SMILES COc1cc(-c2nc3N4CCOC[C@H]4COc3c(n2)C2(CC2)S(C)(=O)=O)c2cc[nH]c2c1
Show InChI InChI=1S/C22H24N4O5S/c1-29-14-9-16(15-3-6-23-17(15)10-14)20-24-19(22(4-5-22)32(2,27)28)18-21(25-20)26-7-8-30-11-13(26)12-31-18/h3,6,9-10,13,23H,4-5,7-8,11-12H2,1-2H3/t13-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 93n/an/an/an/an/an/a



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM251634
PNG
(US9453031, 71)
Show SMILES CC(C)(c1nc(nc2N3CCOC[C@H]3COc12)-c1cc(F)cc2[nH]ccc12)S(C)(=O)=O
Show InChI InChI=1S/C21H23FN4O4S/c1-21(2,31(3,27)28)18-17-20(26-6-7-29-10-13(26)11-30-17)25-19(24-18)15-8-12(22)9-16-14(15)4-5-23-16/h4-5,8-9,13,23H,6-7,10-11H2,1-3H3/t13-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 99.3n/an/an/an/an/an/a



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ...


Citation and Details
More data for this
Ligand-Target Pair
DNA-dependent protein kinase


(Homo sapiens (Human))
BDBM251651
PNG
(US9453031, 102)
Show SMILES CC(C)(c1nc(nc2N3CCOC[C@H]3COc12)-c1ccc(F)c2[nH]ccc12)S(C)(=O)=O
Show InChI InChI=1S/C21H23FN4O4S/c1-21(2,31(3,27)28)18-17-20(26-8-9-29-10-12(26)11-30-17)25-19(24-18)14-4-5-15(22)16-13(14)6-7-23-16/h4-7,12,23H,8-11H2,1-3H3/t12-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 100n/an/an/an/an/an/a



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The kinase activity was measured by using the commercial ADP Hunter Plus assay available from DiscoveRx (#90-0083), which is a homogeneous assay to m...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM251647
PNG
(US9453031, 93)
Show SMILES Cc1cc2c(cccc2[nH]1)-c1nc2N3CCOC[C@H]3COc2c(n1)C1(CCC1)S(C)(=O)=O
Show InChI InChI=1S/C23H26N4O4S/c1-14-11-17-16(5-3-6-18(17)24-14)21-25-20(23(7-4-8-23)32(2,28)29)19-22(26-21)27-9-10-30-12-15(27)13-31-19/h3,5-6,11,15,24H,4,7-10,12-13H2,1-2H3/t15-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 117n/an/an/an/an/an/a



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM251578
PNG
(US9453031, 1)
Show SMILES CC(C)(c1nc(nc2N3CCOCC3COc12)-c1cccc2[nH]ccc12)S(C)(=O)=O
Show InChI InChI=1S/C21H24N4O4S/c1-21(2,30(3,26)27)18-17-20(25-9-10-28-11-13(25)12-29-17)24-19(23-18)15-5-4-6-16-14(15)7-8-22-16/h4-8,13,22H,9-12H2,1-3H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 146n/an/an/an/an/an/a



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM251630
PNG
(US9453031, 67)
Show SMILES CS(=O)(=O)C1(CCC1)c1nc(nc2N3CCOC[C@H]3COc12)-c1cccc2[nH]ccc12
Show InChI InChI=1S/C22H24N4O4S/c1-31(27,28)22(7-3-8-22)19-18-21(26-10-11-29-12-14(26)13-30-18)25-20(24-19)16-4-2-5-17-15(16)6-9-23-17/h2,4-6,9,14,23H,3,7-8,10-13H2,1H3/t14-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 151n/an/an/an/an/an/a



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM251637
PNG
(US9453031, 74)
Show SMILES CS(=O)(=O)C1(CC1)c1nc(nc2N3CCOC[C@H]3COc12)-c1cc(F)cc2[nH]ccc12
Show InChI InChI=1S/C21H21FN4O4S/c1-31(27,28)21(3-4-21)18-17-20(26-6-7-29-10-13(26)11-30-17)25-19(24-18)15-8-12(22)9-16-14(15)2-5-23-16/h2,5,8-9,13,23H,3-4,6-7,10-11H2,1H3/t13-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 152n/an/an/an/an/an/a



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM251582
PNG
(US9453031, 5)
Show SMILES FC(F)(F)S(=O)(=O)Cc1nc(nc2N3CCOCC3COc12)-c1cccc2[nH]ccc12
Show InChI InChI=1S/C19H17F3N4O4S/c20-19(21,22)31(27,28)10-15-16-18(26-6-7-29-8-11(26)9-30-16)25-17(24-15)13-2-1-3-14-12(13)4-5-23-14/h1-5,11,23H,6-10H2
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 194n/an/an/an/an/an/a



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ...


Citation and Details
More data for this
Ligand-Target Pair
DNA-dependent protein kinase


(Homo sapiens (Human))
BDBM251627
PNG
(US9453031, 64)
Show SMILES CCNc1nc2ccccc2n1-c1nc2N3CCOC[C@H]3COc2c(n1)C(C)(C)S(C)(=O)=O
Show InChI InChI=1S/C22H28N6O4S/c1-5-23-20-24-15-8-6-7-9-16(15)28(20)21-25-18(22(2,3)33(4,29)30)17-19(26-21)27-10-11-31-12-14(27)13-32-17/h6-9,14H,5,10-13H2,1-4H3,(H,23,24)/t14-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 196n/an/an/an/an/an/a



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The kinase activity was measured by using the commercial ADP Hunter Plus assay available from DiscoveRx (#90-0083), which is a homogeneous assay to m...


Citation and Details
More data for this
Ligand-Target Pair
DNA-dependent protein kinase


(Homo sapiens (Human))
BDBM251662
PNG
(US9453031, 87)
Show SMILES CNc1nc2ccc(Cl)cc2n1-c1nc2N3CCOC[C@H]3COc2c(n1)C1(CC1)S(C)(=O)=O
Show InChI InChI=1S/C21H23ClN6O4S/c1-23-19-24-14-4-3-12(22)9-15(14)28(19)20-25-17(21(5-6-21)33(2,29)30)16-18(26-20)27-7-8-31-10-13(27)11-32-16/h3-4,9,13H,5-8,10-11H2,1-2H3,(H,23,24)/t13-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 210n/an/an/an/an/an/a



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The kinase activity was measured by using the commercial ADP Hunter Plus assay available from DiscoveRx (#90-0083), which is a homogeneous assay to m...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM251656
PNG
(US9453031, 109)
Show SMILES Cc1cc2c(cccc2[nH]1)-c1nc2N3CCOC[C@H]3COc2c(n1)C1(CC1)S(C)(=O)=O
Show InChI InChI=1S/C22H24N4O4S/c1-13-10-16-15(4-3-5-17(16)23-13)20-24-19(22(6-7-22)31(2,27)28)18-21(25-20)26-8-9-29-11-14(26)12-30-18/h3-5,10,14,23H,6-9,11-12H2,1-2H3/t14-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 224n/an/an/an/an/an/a



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM251633
PNG
(US9453031, 70)
Show SMILES CC(C)(c1nc(nc2N3CCOC[C@H]3COc12)[N]1=C(N)Nc2ccccc12)S(C)(=O)=O
Show InChI InChI=1S/C20H25N6O4S/c1-20(2,31(3,27)28)16-15-17(25-8-9-29-10-12(25)11-30-15)24-19(23-16)26-14-7-5-4-6-13(14)22-18(26)21/h4-7,12,22H,8-11,21H2,1-3H3/t12-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 226n/an/an/an/an/an/a



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM251650
PNG
(US9453031, 101)
Show SMILES CC(C)(c1nc(nc2N3CCOC[C@H]3COc12)-c1cc(cc2[nH]ccc12)C(F)(F)F)S(C)(=O)=O
Show InChI InChI=1S/C22H23F3N4O4S/c1-21(2,34(3,30)31)18-17-20(29-6-7-32-10-13(29)11-33-17)28-19(27-18)15-8-12(22(23,24)25)9-16-14(15)4-5-26-16/h4-5,8-9,13,26H,6-7,10-11H2,1-3H3/t13-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 227n/an/an/an/an/an/a



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM251624
PNG
(US9453031, 61)
Show SMILES CC(C)(c1nc(nc2N3CCOC[C@H]3COc12)-c1cccc2[nH]ccc12)S(=O)(=O)C1CC1
Show InChI InChI=1S/C23H26N4O4S/c1-23(2,32(28,29)15-6-7-15)20-19-22(27-10-11-30-12-14(27)13-31-19)26-21(25-20)17-4-3-5-18-16(17)8-9-24-18/h3-5,8-9,14-15,24H,6-7,10-13H2,1-2H3/t14-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 228n/an/an/an/an/an/a



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM251658
PNG
(US9453031, 112)
Show SMILES CS(=O)(=O)C1(CCC1)c1nc(nc2N3CCOC[C@H]3COc12)-c1cc(cc2[nH]ccc12)C(F)(F)F
Show InChI InChI=1S/C23H23F3N4O4S/c1-35(31,32)22(4-2-5-22)19-18-21(30-7-8-33-11-14(30)12-34-18)29-20(28-19)16-9-13(23(24,25)26)10-17-15(16)3-6-27-17/h3,6,9-10,14,27H,2,4-5,7-8,11-12H2,1H3/t14-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 235n/an/an/an/an/an/a



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM251626
PNG
(US9453031, 63)
Show SMILES CC(C)Nc1nc2ccccc2n1-c1nc2N3CCOC[C@H]3COc2c(n1)C(C)(C)S(C)(=O)=O
Show InChI InChI=1S/C23H30N6O4S/c1-14(2)24-21-25-16-8-6-7-9-17(16)29(21)22-26-19(23(3,4)34(5,30)31)18-20(27-22)28-10-11-32-12-15(28)13-33-18/h6-9,14-15H,10-13H2,1-5H3,(H,24,25)/t15-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 252n/an/an/an/an/an/a



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM251581
PNG
(US9453031, 4)
Show SMILES CC(C)(c1nc(nc2N3CCOCC3COc12)-c1cccc2[nH]ccc12)S(=O)(=O)C1CC1
Show InChI InChI=1S/C23H26N4O4S/c1-23(2,32(28,29)15-6-7-15)20-19-22(27-10-11-30-12-14(27)13-31-19)26-21(25-20)17-4-3-5-18-16(17)8-9-24-18/h3-5,8-9,14-15,24H,6-7,10-13H2,1-2H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 274n/an/an/an/an/an/a



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM251615
PNG
(US9453031, 38)
Show SMILES CC(C)(O)c1nc(nc2N3CCOCC3COc12)-c1cccc2[nH]ccc12
Show InChI InChI=1S/C20H22N4O3/c1-20(2,25)17-16-19(24-8-9-26-10-12(24)11-27-16)23-18(22-17)14-4-3-5-15-13(14)6-7-21-15/h3-7,12,21,25H,8-11H2,1-2H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 275n/an/an/an/an/an/a



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM251617
PNG
(US9453031, 40)
Show SMILES CC(C)(C#N)c1nc(nc2N3CCOCC3COc12)-c1cccc2[nH]ccc12
Show InChI InChI=1S/C21H21N5O2/c1-21(2,12-22)18-17-20(26-8-9-27-10-13(26)11-28-17)25-19(24-18)15-4-3-5-16-14(15)6-7-23-16/h3-7,13,23H,8-11H2,1-2H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 279n/an/an/an/an/an/a



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM251632
PNG
(US9453031, 69)
Show SMILES CS(=O)(=O)C1(CCNCC1)c1nc(nc2N3CCOC[C@H]3COc12)-c1cccc2[nH]ccc12
Show InChI InChI=1S/C23H27N5O4S/c1-33(29,30)23(6-9-24-10-7-23)20-19-22(28-11-12-31-13-15(28)14-32-19)27-21(26-20)17-3-2-4-18-16(17)5-8-25-18/h2-5,8,15,24-25H,6-7,9-14H2,1H3/t15-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 336n/an/an/an/an/an/a



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM251618
PNG
(US9453031, 41)
Show SMILES CC1(CCCS1(=O)=O)c1nc(nc2N3CCOCC3COc12)-c1cccc2[nH]ccc12
Show InChI InChI=1S/C22H24N4O4S/c1-22(7-3-11-31(22,27)28)19-18-21(26-9-10-29-12-14(26)13-30-18)25-20(24-19)16-4-2-5-17-15(16)6-8-23-17/h2,4-6,8,14,23H,3,7,9-13H2,1H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 381n/an/an/an/an/an/a



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM251598
PNG
(US9453031, 21)
Show SMILES CC(C)(c1nc(nc2N3CCOC[C@@H]3COc12)-c1cccc2[nH]ncc12)S(C)(=O)=O
Show InChI InChI=1S/C20H23N5O4S/c1-20(2,30(3,26)27)17-16-19(25-7-8-28-10-12(25)11-29-16)23-18(22-17)13-5-4-6-15-14(13)9-21-24-15/h4-6,9,12H,7-8,10-11H2,1-3H3,(H,21,24)/t12-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 400n/an/an/an/an/an/a



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The kinase activity was measured by using the commercial ADP Hunter Plus assay available from DiscoveRx (#33-016), which is a homogeneous assay to me...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM251619
PNG
(US9453031, 42)
Show SMILES C1CN2C(CO1)COc1c2nc(nc1-c1cccc2[nH]ccc12)-c1cccc2[nH]ccc12
Show InChI InChI=1S/C25H21N5O2/c1-3-18(16-7-9-26-20(16)5-1)22-23-25(30-11-12-31-13-15(30)14-32-23)29-24(28-22)19-4-2-6-21-17(19)8-10-27-21/h1-10,15,26-27H,11-14H2
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 412n/an/an/an/an/an/a



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM251606
PNG
(US9453031, 29)
Show SMILES COc1cc(-c2nc3N4CCOC[C@H]4COc3c(n2)C2(CCOCC2)S(C)(=O)=O)c2cc[nH]c2c1
Show InChI InChI=1S/C24H28N4O6S/c1-31-16-11-18(17-3-6-25-19(17)12-16)22-26-21(24(35(2,29)30)4-8-32-9-5-24)20-23(27-22)28-7-10-33-13-15(28)14-34-20/h3,6,11-12,15,25H,4-5,7-10,13-14H2,1-2H3/t15-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 435n/an/an/an/an/an/a



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM251623
PNG
(US9453031, 46)
Show SMILES COc1cc(-c2nc3N4CCOC[C@H]4COc3c(n2)C(C)(C)O)c2cc[nH]c2c1
Show InChI InChI=1S/C21H24N4O4/c1-21(2,26)18-17-20(25-6-7-28-10-12(25)11-29-17)24-19(23-18)15-8-13(27-3)9-16-14(15)4-5-22-16/h4-5,8-9,12,22,26H,6-7,10-11H2,1-3H3/t12-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 480n/an/an/an/an/an/a



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The kinase activity was measured by using the commercial ADP Hunter Plus assay available from DiscoveRx (#33-016), which is a homogeneous assay to me...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM251643
PNG
(US9453031, 80)
Show SMILES CNc1nc2cc(Cl)ccc2n1-c1nc2N3CCOC[C@H]3COc2c(n1)C(C)(C)S(C)(=O)=O
Show InChI InChI=1S/C21H25ClN6O4S/c1-21(2,33(4,29)30)17-16-18(27-7-8-31-10-13(27)11-32-16)26-20(25-17)28-15-6-5-12(22)9-14(15)24-19(28)23-3/h5-6,9,13H,7-8,10-11H2,1-4H3,(H,23,24)/t13-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 501n/an/an/an/an/an/a



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM251627
PNG
(US9453031, 64)
Show SMILES CCNc1nc2ccccc2n1-c1nc2N3CCOC[C@H]3COc2c(n1)C(C)(C)S(C)(=O)=O
Show InChI InChI=1S/C22H28N6O4S/c1-5-23-20-24-15-8-6-7-9-16(15)28(20)21-25-18(22(2,3)33(4,29)30)17-19(26-21)27-10-11-31-12-14(27)13-32-17/h6-9,14H,5,10-13H2,1-4H3,(H,23,24)/t14-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 505n/an/an/an/an/an/a



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM251604
PNG
(US9453031, 27)
Show SMILES CS(=O)(=O)C1(CC1)c1nc(nc2N3CCOCC3COc12)-c1cccc2[nH]ccc12
Show InChI InChI=1S/C21H22N4O4S/c1-30(26,27)21(6-7-21)18-17-20(25-9-10-28-11-13(25)12-29-17)24-19(23-18)15-3-2-4-16-14(15)5-8-22-16/h2-5,8,13,22H,6-7,9-12H2,1H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM251583
PNG
(US9453031, 6)
Show SMILES CS(=O)(=O)C1(CC1)c1nc(nc2N3CCOC[C@H]3COc12)-c1cccc2[nH]ccc12
Show InChI InChI=1S/C21H22N4O4S/c1-30(26,27)21(6-7-21)18-17-20(25-9-10-28-11-13(25)12-29-17)24-19(23-18)15-3-2-4-16-14(15)5-8-22-16/h2-5,8,13,22H,6-7,9-12H2,1H3/t13-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 558n/an/an/an/an/an/a



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM251655
PNG
(US9453031, 108)
Show SMILES CS(=O)(=O)C1(CC1)c1nc(nc2N3CCOC[C@H]3COc12)-c1cc(cc2[nH]ccc12)C(F)(F)F
Show InChI InChI=1S/C22H21F3N4O4S/c1-34(30,31)21(3-4-21)18-17-20(29-6-7-32-10-13(29)11-33-17)28-19(27-18)15-8-12(22(23,24)25)9-16-14(15)2-5-26-16/h2,5,8-9,13,26H,3-4,6-7,10-11H2,1H3/t13-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 579n/an/an/an/an/an/a



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM251602
PNG
(US9453031, 25)
Show SMILES CC(C)(c1nc(nc2N3CCOC[C@H]3CCOc12)-c1cccc2[nH]ccc12)S(C)(=O)=O
Show InChI InChI=1S/C22H26N4O4S/c1-22(2,31(3,27)28)19-18-21(26-10-12-29-13-14(26)8-11-30-18)25-20(24-19)16-5-4-6-17-15(16)7-9-23-17/h4-7,9,14,23H,8,10-13H2,1-3H3/t14-/m1/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 582n/an/an/an/an/an/a



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM251608
PNG
(US9453031, 31)
Show SMILES CNc1nc2ccccc2n1-c1nc2N3CCOCC3CCOc2c(n1)C(C)(C)S(C)(=O)=O
Show InChI InChI=1S/C22H28N6O4S/c1-22(2,33(4,29)30)18-17-19(27-10-12-31-13-14(27)9-11-32-17)26-21(25-18)28-16-8-6-5-7-15(16)24-20(28)23-3/h5-8,14H,9-13H2,1-4H3,(H,23,24)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 586n/an/an/an/an/an/a



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM251585
PNG
(US9453031, 8)
Show SMILES CNc1nc2ccccc2n1-c1nc2N3CCOCC3COc2c(n1)C(C)(C)S(C)(=O)=O
Show InChI InChI=1S/C21H26N6O4S/c1-21(2,32(4,28)29)17-16-18(26-9-10-30-11-13(26)12-31-16)25-20(24-17)27-15-8-6-5-7-14(15)23-19(27)22-3/h5-8,13H,9-12H2,1-4H3,(H,22,23)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 588n/an/an/an/an/an/a



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM251588
PNG
(US9453031, 11)
Show SMILES CNc1nc2ccccc2n1-c1nc2N3CCOC[C@H]3COc2c(n1)C(C)(C)S(C)(=O)=O
Show InChI InChI=1S/C21H26N6O4S/c1-21(2,32(4,28)29)17-16-18(26-9-10-30-11-13(26)12-31-16)25-20(24-17)27-15-8-6-5-7-14(15)23-19(27)22-3/h5-8,13H,9-12H2,1-4H3,(H,22,23)/t13-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 604n/an/an/an/an/an/a



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM251593
PNG
(US9453031, 16)
Show SMILES CC(C)(c1nc(nc2N3CCOCC3COc12)-c1ccnc2[nH]ccc12)S(C)(=O)=O
Show InChI InChI=1S/C20H23N5O4S/c1-20(2,30(3,26)27)16-15-19(25-8-9-28-10-12(25)11-29-15)24-18(23-16)14-5-7-22-17-13(14)4-6-21-17/h4-7,12H,8-11H2,1-3H3,(H,21,22)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 670n/an/an/an/an/an/a



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The kinase activity was measured by using the commercial ADP Hunter Plus assay available from DiscoveRx (#33-016), which is a homogeneous assay to me...


Citation and Details
More data for this
Ligand-Target Pair
DNA-dependent protein kinase


(Homo sapiens (Human))
BDBM251633
PNG
(US9453031, 70)
Show SMILES CC(C)(c1nc(nc2N3CCOC[C@H]3COc12)[N]1=C(N)Nc2ccccc12)S(C)(=O)=O
Show InChI InChI=1S/C20H25N6O4S/c1-20(2,31(3,27)28)16-15-17(25-8-9-29-10-12(25)11-30-15)24-19(23-16)26-14-7-5-4-6-13(14)22-18(26)21/h4-7,12,22H,8-11,21H2,1-3H3/t12-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 741n/an/an/an/an/an/a



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The kinase activity was measured by using the commercial ADP Hunter Plus assay available from DiscoveRx (#90-0083), which is a homogeneous assay to m...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM251605
PNG
(US9453031, 28)
Show SMILES CS(=O)(=O)C1(CCOCC1)c1nc(nc2N3CCOC[C@H]3COc12)-c1cc(F)cc2[nH]ccc12
Show InChI InChI=1S/C23H25FN4O5S/c1-34(29,30)23(3-7-31-8-4-23)20-19-22(28-6-9-32-12-15(28)13-33-19)27-21(26-20)17-10-14(24)11-18-16(17)2-5-25-18/h2,5,10-11,15,25H,3-4,6-9,12-13H2,1H3/t15-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 785n/an/an/an/an/an/a



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM251611
PNG
(US9453031, 34)
Show SMILES COc1cc(-c2nc3N4CCOCC4CCOc3c(n2)C2(CCOCC2)S(C)(=O)=O)c2cc[nH]c2c1
Show InChI InChI=1S/C25H30N4O6S/c1-32-17-13-19(18-3-7-26-20(18)14-17)23-27-22(25(36(2,30)31)5-10-33-11-6-25)21-24(28-23)29-8-12-34-15-16(29)4-9-35-21/h3,7,13-14,16,26H,4-6,8-12,15H2,1-2H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 808n/an/an/an/an/an/a



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM251635
PNG
(US9453031, 72)
Show SMILES COc1cc(-c2nc3N4CCOC[C@H]4COc3c(n2)C(C)(C)S(C)(=O)=O)c2cc[nH]c2c1
Show InChI InChI=1S/C22H26N4O5S/c1-22(2,32(4,27)28)19-18-21(26-7-8-30-11-13(26)12-31-18)25-20(24-19)16-9-14(29-3)10-17-15(16)5-6-23-17/h5-6,9-10,13,23H,7-8,11-12H2,1-4H3/t13-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 820n/an/an/an/an/an/a



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The kinase activity was measured by using the commercial ADP Hunter Plus assay available from DiscoveRx (#33-016), which is a homogeneous assay to me...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM251592
PNG
(US9453031, 15)
Show SMILES CC(C)(c1nc(nc2N3CCOC[C@@H]3COc12)-c1cccc2[nH]ccc12)S(C)(=O)=O
Show InChI InChI=1S/C21H24N4O4S/c1-21(2,30(3,26)27)18-17-20(25-9-10-28-11-13(25)12-29-17)24-19(23-18)15-5-4-6-16-14(15)7-8-22-16/h4-8,13,22H,9-12H2,1-3H3/t13-/m1/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 851n/an/an/an/an/an/a



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM251593
PNG
(US9453031, 16)
Show SMILES CC(C)(c1nc(nc2N3CCOCC3COc12)-c1ccnc2[nH]ccc12)S(C)(=O)=O
Show InChI InChI=1S/C20H23N5O4S/c1-20(2,30(3,26)27)16-15-19(25-8-9-28-10-12(25)11-29-15)24-18(23-16)14-5-7-22-17-13(14)4-6-21-17/h4-7,12H,8-11H2,1-3H3,(H,21,22)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 852n/an/an/an/an/an/a



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM251629
PNG
(US9453031, 66)
Show SMILES CNc1nc2ccccc2n1-c1nc2N3CCOC[C@H]3COc2c(n1)C1(CC1)S(C)(=O)=O
Show InChI InChI=1S/C21H24N6O4S/c1-22-19-23-14-5-3-4-6-15(14)27(19)20-24-17(21(7-8-21)32(2,28)29)16-18(25-20)26-9-10-30-11-13(26)12-31-16/h3-6,13H,7-12H2,1-2H3,(H,22,23)/t13-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 854n/an/an/an/an/an/a



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ...


Citation and Details
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM251633
PNG
(US9453031, 70)
Show SMILES CC(C)(c1nc(nc2N3CCOC[C@H]3COc12)[N]1=C(N)Nc2ccccc12)S(C)(=O)=O
Show InChI InChI=1S/C20H25N6O4S/c1-20(2,31(3,27)28)16-15-17(25-8-9-29-10-12(25)11-30-15)24-19(23-16)26-14-7-5-4-6-13(14)22-18(26)21/h4-7,12,22H,8-11,21H2,1-3H3/t12-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 870n/an/an/an/an/an/a



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The kinase activity was measured by using the commercial ADP Hunter Plus assay available from DiscoveRx (#33-016), which is a homogeneous assay to me...


Citation and Details
More data for this
Ligand-Target Pair
DNA-dependent protein kinase


(Homo sapiens (Human))
BDBM251622
PNG
(US9453031, 45)
Show SMILES CC(C)(O)c1nc(nc2N3CCOC[C@H]3COc12)-c1cc(F)cc2[nH]ccc12
Show InChI InChI=1S/C20H21FN4O3/c1-20(2,26)17-16-19(25-5-6-27-9-12(25)10-28-16)24-18(23-17)14-7-11(21)8-15-13(14)3-4-22-15/h3-4,7-8,12,22,26H,5-6,9-10H2,1-2H3/t12-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 886n/an/an/an/an/an/a



Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

US Patent


Assay Description
The kinase activity was measured by using the commercial ADP Hunter Plus assay available from DiscoveRx (#90-0083), which is a homogeneous assay to m...


Citation and Details
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 272 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%