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Patent code US9458140

Compile Data Set for Download or QSAR
Found 29 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
B-RAF V600E


(Homo sapiens (Human))
BDBM249254
PNG
(US9458140, 12)
Show SMILES CC1(C)OC(=C(C1=O)c1cc(Cl)cc(NS(=O)(=O)c2cc(F)ccc2F)c1F)c1ccnc(N)n1
Show InChI InChI=1S/C22H16ClF3N4O4S/c1-22(2)20(31)17(19(34-22)14-5-6-28-21(27)29-14)12-7-10(23)8-15(18(12)26)30-35(32,33)16-9-11(24)3-4-13(16)25/h3-9,30H,1-2H3,(H2,27,28,29)
PDB

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UniChem
US Patent
n/an/a 0.600n/an/an/an/an/an/a



Eternity Bioscience Inc.

US Patent


Assay Description
The BRAFV600E enzymatic assay was performed using a LanthaScreen kinase assay kit purchased from Life Technologies (Grand Island, N.Y.). The assay wa...


Citation and Details
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM249256
PNG
(US9458140, 14)
Show SMILES CC1(C)OC(=C(C1=O)c1cc(Cl)cc(NS(=O)(=O)c2cccc(F)c2)c1F)c1ccnc(N)n1
Show InChI InChI=1S/C22H17ClF2N4O4S/c1-22(2)20(30)17(19(33-22)15-6-7-27-21(26)28-15)14-8-11(23)9-16(18(14)25)29-34(31,32)13-5-3-4-12(24)10-13/h3-10,29H,1-2H3,(H2,26,27,28)
PDB

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UniChem
US Patent
n/an/a 1.20n/an/an/an/an/an/a



Eternity Bioscience Inc.

US Patent


Assay Description
The BRAFV600E enzymatic assay was performed using a LanthaScreen kinase assay kit purchased from Life Technologies (Grand Island, N.Y.). The assay wa...


Citation and Details
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM249270
PNG
(US9458140, 29)
Show SMILES Nc1nccc(n1)C1=C(C(=O)C2(CCCC2)O1)c1cc(Cl)cc(NS(=O)(=O)c2c(F)cccc2F)c1F
Show InChI InChI=1S/C24H18ClF3N4O4S/c25-12-10-13(19(28)17(11-12)32-37(34,35)21-14(26)4-3-5-15(21)27)18-20(16-6-9-30-23(29)31-16)36-24(22(18)33)7-1-2-8-24/h3-6,9-11,32H,1-2,7-8H2,(H2,29,30,31)
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US Patent
n/an/a 1.30n/an/an/an/an/an/a



Eternity Bioscience Inc.

US Patent


Assay Description
The BRAFV600E enzymatic assay was performed using a LanthaScreen kinase assay kit purchased from Life Technologies (Grand Island, N.Y.). The assay wa...


Citation and Details
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM249260
PNG
(US9458140, 18)
Show SMILES Nc1nccc(n1)C1=C(C(=O)C2(CCCC2)O1)c1cc(Cl)cc(NS(=O)(=O)c2c(F)cccc2F)c1Cl
Show InChI InChI=1S/C24H18Cl2F2N4O4S/c25-12-10-13(19(26)17(11-12)32-37(34,35)21-14(27)4-3-5-15(21)28)18-20(16-6-9-30-23(29)31-16)36-24(22(18)33)7-1-2-8-24/h3-6,9-11,32H,1-2,7-8H2,(H2,29,30,31)
PDB

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US Patent
n/an/a 2.40n/an/an/an/an/an/a



Eternity Bioscience Inc.

US Patent


Assay Description
The BRAFV600E enzymatic assay was performed using a LanthaScreen kinase assay kit purchased from Life Technologies (Grand Island, N.Y.). The assay wa...


Citation and Details
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM249262
PNG
(US9458140, 21)
Show SMILES CC1(C)OC(=C(C1=O)c1cc(Cl)cc(NS(=O)(=O)c2c(F)cccc2F)c1F)c1ccnc(NCCC#N)n1
Show InChI InChI=1S/C25H19ClF3N5O4S/c1-25(2)23(35)19(21(38-25)17-7-10-32-24(33-17)31-9-4-8-30)14-11-13(26)12-18(20(14)29)34-39(36,37)22-15(27)5-3-6-16(22)28/h3,5-7,10-12,34H,4,9H2,1-2H3,(H,31,32,33)
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US Patent
n/an/a 2.5n/an/an/an/an/an/a



Eternity Bioscience Inc.

US Patent


Assay Description
The BRAFV600E enzymatic assay was performed using a LanthaScreen kinase assay kit purchased from Life Technologies (Grand Island, N.Y.). The assay wa...


Citation and Details
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM249257
PNG
(US9458140, 15)
Show SMILES CC1(C)OC(=C(C1=O)c1cc(Cl)cc(NS(=O)(=O)c2ccccc2F)c1F)c1ccnc(N)n1
Show InChI InChI=1S/C22H17ClF2N4O4S/c1-22(2)20(30)17(19(33-22)14-7-8-27-21(26)28-14)12-9-11(23)10-15(18(12)25)29-34(31,32)16-6-4-3-5-13(16)24/h3-10,29H,1-2H3,(H2,26,27,28)
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Eternity Bioscience Inc.

US Patent


Assay Description
The BRAFV600E enzymatic assay was performed using a LanthaScreen kinase assay kit purchased from Life Technologies (Grand Island, N.Y.). The assay wa...


Citation and Details
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM249269
PNG
(US9458140, 28)
Show SMILES Nc1nccc(n1)C1=C(C(=O)C2(CCCC2)O1)c1cc(Cl)cc(NS(=O)(=O)c2cc(F)ccc2F)c1F
Show InChI InChI=1S/C24H18ClF3N4O4S/c25-12-9-14(20(28)17(10-12)32-37(34,35)18-11-13(26)3-4-15(18)27)19-21(16-5-8-30-23(29)31-16)36-24(22(19)33)6-1-2-7-24/h3-5,8-11,32H,1-2,6-7H2,(H2,29,30,31)
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US Patent
n/an/a 2.60n/an/an/an/an/an/a



Eternity Bioscience Inc.

US Patent


Assay Description
The BRAFV600E enzymatic assay was performed using a LanthaScreen kinase assay kit purchased from Life Technologies (Grand Island, N.Y.). The assay wa...


Citation and Details
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM249268
PNG
(US9458140, 27)
Show SMILES CCNc1nccc(n1)C1=C(C(=O)C(C)(C)O1)c1cc(Cl)cc(NS(=O)(=O)c2cc(F)ccc2F)c1F
Show InChI InChI=1S/C24H20ClF3N4O4S/c1-4-29-23-30-8-7-16(31-23)21-19(22(33)24(2,3)36-21)14-9-12(25)10-17(20(14)28)32-37(34,35)18-11-13(26)5-6-15(18)27/h5-11,32H,4H2,1-3H3,(H,29,30,31)
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US Patent
n/an/a 2.80n/an/an/an/an/an/a



Eternity Bioscience Inc.

US Patent


Assay Description
The BRAFV600E enzymatic assay was performed using a LanthaScreen kinase assay kit purchased from Life Technologies (Grand Island, N.Y.). The assay wa...


Citation and Details
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM249259
PNG
(US9458140, 17)
Show SMILES Nc1nccc(n1)C1=C(C(=O)C2(CCCC2)O1)c1cccc(NS(=O)(=O)c2c(F)cccc2F)c1Cl
Show InChI InChI=1S/C24H19ClF2N4O4S/c25-19-13(5-3-8-16(19)31-36(33,34)21-14(26)6-4-7-15(21)27)18-20(17-9-12-29-23(28)30-17)35-24(22(18)32)10-1-2-11-24/h3-9,12,31H,1-2,10-11H2,(H2,28,29,30)
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n/an/a 3.70n/an/an/an/an/an/a



Eternity Bioscience Inc.

US Patent


Assay Description
The BRAFV600E enzymatic assay was performed using a LanthaScreen kinase assay kit purchased from Life Technologies (Grand Island, N.Y.). The assay wa...


Citation and Details
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM249253
PNG
(US9458140, 11)
Show SMILES CC1(C)OC(=C(C1=O)c1cc(Cl)cc(NS(=O)(=O)c2c(F)cccc2F)c1F)c1ccnc(N)n1
Show InChI InChI=1S/C22H16ClF3N4O4S/c1-22(2)20(31)16(18(34-22)14-6-7-28-21(27)29-14)11-8-10(23)9-15(17(11)26)30-35(32,33)19-12(24)4-3-5-13(19)25/h3-9,30H,1-2H3,(H2,27,28,29)
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US Patent
n/an/a 5.5n/an/an/an/an/an/a



Eternity Bioscience Inc.

US Patent


Assay Description
The BRAFV600E enzymatic assay was performed using a LanthaScreen kinase assay kit purchased from Life Technologies (Grand Island, N.Y.). The assay wa...


Citation and Details
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM249248
PNG
(US9458140, 6)
Show SMILES CC(C)CC1(C)OC(=C(C1=O)c1cccc(NS(=O)(=O)c2c(F)cccc2F)c1F)c1ccnc(NCCC#N)n1
Show InChI InChI=1S/C28H26F3N5O4S/c1-16(2)15-28(3)26(37)22(24(40-28)21-11-14-34-27(35-21)33-13-6-12-32)17-7-4-10-20(23(17)31)36-41(38,39)25-18(29)8-5-9-19(25)30/h4-5,7-11,14,16,36H,6,13,15H2,1-3H3,(H,33,34,35)
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US Patent
n/an/a 9.60n/an/an/an/an/an/a



Eternity Bioscience Inc.

US Patent


Assay Description
The BRAFV600E enzymatic assay was performed using a LanthaScreen kinase assay kit purchased from Life Technologies (Grand Island, N.Y.). The assay wa...


Citation and Details
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM249255
PNG
(US9458140, 13)
Show SMILES CC1(C)OC(=C(C1=O)c1cc(Cl)cc(NS(=O)(=O)c2ccc(F)cc2F)c1F)c1ccnc(N)n1
Show InChI InChI=1S/C22H16ClF3N4O4S/c1-22(2)20(31)17(19(34-22)14-5-6-28-21(27)29-14)12-7-10(23)8-15(18(12)26)30-35(32,33)16-4-3-11(24)9-13(16)25/h3-9,30H,1-2H3,(H2,27,28,29)
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Eternity Bioscience Inc.

US Patent


Assay Description
The BRAFV600E enzymatic assay was performed using a LanthaScreen kinase assay kit purchased from Life Technologies (Grand Island, N.Y.). The assay wa...


Citation and Details
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM249266
PNG
(US9458140, 25)
Show SMILES CC1(C)OC(=C(C1=O)c1cc(Cl)cc(NS(=O)(=O)c2cc(F)ccc2F)c1F)c1ccnc(NCCO)n1
Show InChI InChI=1S/C24H20ClF3N4O5S/c1-24(2)22(34)19(21(37-24)16-5-6-29-23(31-16)30-7-8-33)14-9-12(25)10-17(20(14)28)32-38(35,36)18-11-13(26)3-4-15(18)27/h3-6,9-11,32-33H,7-8H2,1-2H3,(H,29,30,31)
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Eternity Bioscience Inc.

US Patent


Assay Description
The BRAFV600E enzymatic assay was performed using a LanthaScreen kinase assay kit purchased from Life Technologies (Grand Island, N.Y.). The assay wa...


Citation and Details
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM249246
PNG
(US9458140, 3)
Show SMILES CC1(C)OC(=C(C1=O)c1cccc(NS(=O)(=O)c2c(F)cccc2F)c1F)c1ccnc(NCCC#N)n1
Show InChI InChI=1S/C25H20F3N5O4S/c1-25(2)23(34)19(21(37-25)18-10-13-31-24(32-18)30-12-5-11-29)14-6-3-9-17(20(14)28)33-38(35,36)22-15(26)7-4-8-16(22)27/h3-4,6-10,13,33H,5,12H2,1-2H3,(H,30,31,32)
PDB

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Eternity Bioscience Inc.

US Patent


Assay Description
The BRAFV600E enzymatic assay was performed using a LanthaScreen kinase assay kit purchased from Life Technologies (Grand Island, N.Y.). The assay wa...


Citation and Details
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM249264
PNG
(US9458140, 23)
Show SMILES CC1(C)OC(=C(C1=O)c1cc(Cl)cc(NS(=O)(=O)c2cc(F)ccc2F)c1F)c1ccnc(NCCC#N)n1
Show InChI InChI=1S/C25H19ClF3N5O4S/c1-25(2)23(35)20(22(38-25)17-6-9-32-24(33-17)31-8-3-7-30)15-10-13(26)11-18(21(15)29)34-39(36,37)19-12-14(27)4-5-16(19)28/h4-6,9-12,34H,3,8H2,1-2H3,(H,31,32,33)
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n/an/a 13n/an/an/an/an/an/a



Eternity Bioscience Inc.

US Patent


Assay Description
The BRAFV600E enzymatic assay was performed using a LanthaScreen kinase assay kit purchased from Life Technologies (Grand Island, N.Y.). The assay wa...


Citation and Details
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM249265
PNG
(US9458140, 24)
Show SMILES C[C@H](O)CNc1nccc(n1)C1=C(C(=O)C(C)(C)O1)c1cc(Cl)cc(NS(=O)(=O)c2cc(F)ccc2F)c1F
Show InChI InChI=1S/C25H22ClF3N4O5S/c1-12(34)11-31-24-30-7-6-17(32-24)22-20(23(35)25(2,3)38-22)15-8-13(26)9-18(21(15)29)33-39(36,37)19-10-14(27)4-5-16(19)28/h4-10,12,33-34H,11H2,1-3H3,(H,30,31,32)/t12-/m0/s1
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n/an/a 24n/an/an/an/an/an/a



Eternity Bioscience Inc.

US Patent


Assay Description
The BRAFV600E enzymatic assay was performed using a LanthaScreen kinase assay kit purchased from Life Technologies (Grand Island, N.Y.). The assay wa...


Citation and Details
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM249249
PNG
(US9458140, 7)
Show SMILES COC(=O)N[C@@H](C)CNc1nccc(n1)C1=C(C(=O)C(C)(CC(C)C)O1)c1cccc(NS(=O)(=O)c2c(F)cccc2F)c1F
Show InChI InChI=1S/C30H32F3N5O6S/c1-16(2)14-30(4)27(39)23(25(44-30)22-12-13-34-28(37-22)35-15-17(3)36-29(40)43-5)18-8-6-11-21(24(18)33)38-45(41,42)26-19(31)9-7-10-20(26)32/h6-13,16-17,38H,14-15H2,1-5H3,(H,36,40)(H,34,35,37)/t17-,30?/m0/s1
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Eternity Bioscience Inc.

US Patent


Assay Description
The BRAFV600E enzymatic assay was performed using a LanthaScreen kinase assay kit purchased from Life Technologies (Grand Island, N.Y.). The assay wa...


Citation and Details
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM249272
PNG
(US9458140, 19)
Show SMILES CC(C)CC1(C)OC(=C(C1=O)c1cc(Cl)cc(NS(=O)(=O)c2c(F)cccc2F)c1F)c1ccnc(N)n1
Show InChI InChI=1S/C25H22ClF3N4O4S/c1-12(2)11-25(3)23(34)19(21(37-25)17-7-8-31-24(30)32-17)14-9-13(26)10-18(20(14)29)33-38(35,36)22-15(27)5-4-6-16(22)28/h4-10,12,33H,11H2,1-3H3,(H2,30,31,32)
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n/an/a 27n/an/an/an/an/an/a



Eternity Bioscience Inc.

US Patent


Assay Description
The BRAFV600E enzymatic assay was performed using a LanthaScreen kinase assay kit purchased from Life Technologies (Grand Island, N.Y.). The assay wa...


Citation and Details
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM249261
PNG
(US9458140, 20)
Show SMILES CC(C)CC1(C)OC(=C(C1=O)c1cc(Cl)cc(NS(=O)(=O)c2c(F)cccc2F)c1F)c1ccnc(NCCC#N)n1
Show InChI InChI=1S/C28H25ClF3N5O4S/c1-15(2)14-28(3)26(38)22(24(41-28)20-8-11-35-27(36-20)34-10-5-9-33)17-12-16(29)13-21(23(17)32)37-42(39,40)25-18(30)6-4-7-19(25)31/h4,6-8,11-13,15,37H,5,10,14H2,1-3H3,(H,34,35,36)
PDB

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n/an/a 29n/an/an/an/an/an/a



Eternity Bioscience Inc.

US Patent


Assay Description
The BRAFV600E enzymatic assay was performed using a LanthaScreen kinase assay kit purchased from Life Technologies (Grand Island, N.Y.). The assay wa...


Citation and Details
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM249247
PNG
(US9458140, 4)
Show SMILES Nc1nccc(n1)C1=C(C(=O)C2(CCCC2)O1)c1cccc(NS(=O)(=O)c2c(F)cccc2F)c1F
Show InChI InChI=1S/C24H19F3N4O4S/c25-14-6-4-7-15(26)21(14)36(33,34)31-16-8-3-5-13(19(16)27)18-20(17-9-12-29-23(28)30-17)35-24(22(18)32)10-1-2-11-24/h3-9,12,31H,1-2,10-11H2,(H2,28,29,30)
PDB

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n/an/a 29n/an/an/an/an/an/a



Eternity Bioscience Inc.

US Patent


Assay Description
The BRAFV600E enzymatic assay was performed using a LanthaScreen kinase assay kit purchased from Life Technologies (Grand Island, N.Y.). The assay wa...


Citation and Details
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM249263
PNG
(US9458140, 22)
Show SMILES COC(=O)N[C@@H](C)CNc1nccc(n1)C1=C(C(=O)C(C)(C)O1)c1cc(Cl)cc(NS(=O)(=O)c2cc(F)ccc2F)c1F
Show InChI InChI=1S/C27H25ClF3N5O6S/c1-13(34-26(38)41-4)12-33-25-32-8-7-18(35-25)23-21(24(37)27(2,3)42-23)16-9-14(28)10-19(22(16)31)36-43(39,40)20-11-15(29)5-6-17(20)30/h5-11,13,36H,12H2,1-4H3,(H,34,38)(H,32,33,35)/t13-/m0/s1
PDB

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Eternity Bioscience Inc.

US Patent


Assay Description
The BRAFV600E enzymatic assay was performed using a LanthaScreen kinase assay kit purchased from Life Technologies (Grand Island, N.Y.). The assay wa...


Citation and Details
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM249267
PNG
(US9458140, 26)
Show SMILES COCCNc1nccc(n1)C1=C(C(=O)C(C)(C)O1)c1cc(Cl)cc(NS(=O)(=O)c2cc(F)ccc2F)c1F
Show InChI InChI=1S/C25H22ClF3N4O5S/c1-25(2)23(34)20(22(38-25)17-6-7-30-24(32-17)31-8-9-37-3)15-10-13(26)11-18(21(15)29)33-39(35,36)19-12-14(27)4-5-16(19)28/h4-7,10-12,33H,8-9H2,1-3H3,(H,30,31,32)
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Eternity Bioscience Inc.

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Assay Description
The BRAFV600E enzymatic assay was performed using a LanthaScreen kinase assay kit purchased from Life Technologies (Grand Island, N.Y.). The assay wa...


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More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM249258
PNG
(US9458140, 16)
Show SMILES CCCS(=O)(=O)Nc1cc(Cl)cc(C2=C(OC(C)(CC(C)C)C2=O)c2ccnc(N)n2)c1F
Show InChI InChI=1S/C22H26ClFN4O4S/c1-5-8-33(30,31)28-16-10-13(23)9-14(18(16)24)17-19(15-6-7-26-21(25)27-15)32-22(4,20(17)29)11-12(2)3/h6-7,9-10,12,28H,5,8,11H2,1-4H3,(H2,25,26,27)
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Eternity Bioscience Inc.

US Patent


Assay Description
The BRAFV600E enzymatic assay was performed using a LanthaScreen kinase assay kit purchased from Life Technologies (Grand Island, N.Y.). The assay wa...


Citation and Details
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM249271
PNG
(US9458140, 5)
Show SMILES CC(C)CC1(C)OC(=C(C1=O)c1cccc(NS(=O)(=O)c2c(F)cccc2F)c1F)c1ccnc(N)n1
Show InChI InChI=1S/C25H23F3N4O4S/c1-13(2)12-25(3)23(33)19(21(36-25)18-10-11-30-24(29)31-18)14-6-4-9-17(20(14)28)32-37(34,35)22-15(26)7-5-8-16(22)27/h4-11,13,32H,12H2,1-3H3,(H2,29,30,31)
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Eternity Bioscience Inc.

US Patent


Assay Description
The BRAFV600E enzymatic assay was performed using a LanthaScreen kinase assay kit purchased from Life Technologies (Grand Island, N.Y.). The assay wa...


Citation and Details
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM249245
PNG
(US9458140, 2)
Show SMILES COC(=O)N[C@@H](C)CNc1nccc(n1)C1=C(C(=O)C(C)(C)O1)c1cccc(NS(=O)(=O)c2c(F)cccc2F)c1F
Show InChI InChI=1S/C27H26F3N5O6S/c1-14(33-26(37)40-4)13-32-25-31-12-11-19(34-25)22-20(24(36)27(2,3)41-22)15-7-5-10-18(21(15)30)35-42(38,39)23-16(28)8-6-9-17(23)29/h5-12,14,35H,13H2,1-4H3,(H,33,37)(H,31,32,34)/t14-/m0/s1
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Eternity Bioscience Inc.

US Patent


Assay Description
The BRAFV600E enzymatic assay was performed using a LanthaScreen kinase assay kit purchased from Life Technologies (Grand Island, N.Y.). The assay wa...


Citation and Details
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM249244
PNG
(US9458140, 1)
Show SMILES CC1(C)OC(=C(C1=O)c1cccc(NS(=O)(=O)c2c(F)cccc2F)c1F)c1ccnc(S)n1
Show InChI InChI=1S/C22H16F3N3O4S2/c1-22(2)20(29)16(18(32-22)15-9-10-26-21(33)27-15)11-5-3-8-14(17(11)25)28-34(30,31)19-12(23)6-4-7-13(19)24/h3-10,28H,1-2H3,(H,26,27,33)
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Eternity Bioscience Inc.

US Patent


Assay Description
The BRAFV600E enzymatic assay was performed using a LanthaScreen kinase assay kit purchased from Life Technologies (Grand Island, N.Y.). The assay wa...


Citation and Details
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM249250
PNG
(US9458140, 8)
Show SMILES CC(C)CC1(C)OC(=C(C1=O)c1cccc(NS(=O)(=O)c2c(F)cccc2F)c1F)c1ccnc(NCc2nccs2)n1
Show InChI InChI=1S/C29H26F3N5O4S2/c1-16(2)14-29(3)27(38)23(25(41-29)21-10-11-34-28(36-21)35-15-22-33-12-13-42-22)17-6-4-9-20(24(17)32)37-43(39,40)26-18(30)7-5-8-19(26)31/h4-13,16,37H,14-15H2,1-3H3,(H,34,35,36)
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Eternity Bioscience Inc.

US Patent


Assay Description
The BRAFV600E enzymatic assay was performed using a LanthaScreen kinase assay kit purchased from Life Technologies (Grand Island, N.Y.). The assay wa...


Citation and Details
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM249252
PNG
(US9458140, 10)
Show SMILES CC(C)CC1(C)OC(=C(C1=O)c1cccc(NS(=O)(=O)c2c(F)cccc2F)c1F)c1ccnc(NCC2CCCO2)n1
Show InChI InChI=1S/C30H31F3N4O5S/c1-17(2)15-30(3)28(38)24(26(42-30)23-12-13-34-29(36-23)35-16-18-7-6-14-41-18)19-8-4-11-22(25(19)33)37-43(39,40)27-20(31)9-5-10-21(27)32/h4-5,8-13,17-18,37H,6-7,14-16H2,1-3H3,(H,34,35,36)
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Eternity Bioscience Inc.

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Assay Description
The BRAFV600E enzymatic assay was performed using a LanthaScreen kinase assay kit purchased from Life Technologies (Grand Island, N.Y.). The assay wa...


Citation and Details
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM249251
PNG
(US9458140, 9)
Show SMILES CC(C)CC1(C)OC(=C(C1=O)c1cccc(NS(=O)(=O)c2c(F)cccc2F)c1F)c1ccnc(NC[C@H]2CCCN2)n1
Show InChI InChI=1S/C30H32F3N5O4S/c1-17(2)15-30(3)28(39)24(26(42-30)23-12-14-35-29(37-23)36-16-18-7-6-13-34-18)19-8-4-11-22(25(19)33)38-43(40,41)27-20(31)9-5-10-21(27)32/h4-5,8-12,14,17-18,34,38H,6-7,13,15-16H2,1-3H3,(H,35,36,37)/t18-,30?/m1/s1
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Eternity Bioscience Inc.

US Patent


Assay Description
The BRAFV600E enzymatic assay was performed using a LanthaScreen kinase assay kit purchased from Life Technologies (Grand Island, N.Y.). The assay wa...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%