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Patent code US9458172

Compile Data Set for Download or QSAR
Found 180 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252532
PNG
(US9458172, 113 | US9458172, 135)
Show SMILES CN1CCN(CC1)c1ccc(cn1)S(=O)(=O)c1ccc(CNC(=O)c2cc3ccncc3o2)nc1
Show InChI InChI=1S/C24H24N6O4S/c1-29-8-10-30(11-9-29)23-5-4-20(15-27-23)35(32,33)19-3-2-18(26-14-19)13-28-24(31)21-12-17-6-7-25-16-22(17)34-21/h2-7,12,14-16H,8-11,13H2,1H3,(H,28,31)
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US Patent


Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252531
PNG
(US9458172, 112 | US9458172, 133)
Show SMILES COc1cc(OC)cc(c1)S(=O)(=O)c1ccc(CNC(=O)c2cc3ccncc3o2)nc1
Show InChI InChI=1S/C22H19N3O6S/c1-29-16-8-17(30-2)10-19(9-16)32(27,28)18-4-3-15(24-12-18)11-25-22(26)20-7-14-5-6-23-13-21(14)31-20/h3-10,12-13H,11H2,1-2H3,(H,25,26)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252531
PNG
(US9458172, 112 | US9458172, 133)
Show SMILES COc1cc(OC)cc(c1)S(=O)(=O)c1ccc(CNC(=O)c2cc3ccncc3o2)nc1
Show InChI InChI=1S/C22H19N3O6S/c1-29-16-8-17(30-2)10-19(9-16)32(27,28)18-4-3-15(24-12-18)11-25-22(26)20-7-14-5-6-23-13-21(14)31-20/h3-10,12-13H,11H2,1-2H3,(H,25,26)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252482
PNG
(US9458172, 54)
Show SMILES O=C(NCc1ccc(cn1)S(=O)(=O)c1ccc(nc1)N1CCOCC1)c1cc2ccncc2s1
Show InChI InChI=1S/C23H21N5O4S2/c29-23(20-11-16-5-6-24-15-21(16)33-20)27-12-17-1-2-18(13-25-17)34(30,31)19-3-4-22(26-14-19)28-7-9-32-10-8-28/h1-6,11,13-15H,7-10,12H2,(H,27,29)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252480
PNG
(US9458172, 52)
Show SMILES O=C(NCc1ccc(cn1)S(=O)(=O)c1ccc(nc1)N1CCOCC1)c1cc2ccncc2o1
Show InChI InChI=1S/C23H21N5O5S/c29-23(20-11-16-5-6-24-15-21(16)33-20)27-12-17-1-2-18(13-25-17)34(30,31)19-3-4-22(26-14-19)28-7-9-32-10-8-28/h1-6,11,13-15H,7-10,12H2,(H,27,29)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252467
PNG
(US9458172, 38)
Show SMILES O=C(NCc1ccc(cn1)S(=O)(=O)c1ccc(cc1)N1CCOCC1)c1cnc2nccn2c1
Show InChI InChI=1S/C23H22N6O4S/c30-22(17-13-27-23-24-7-8-29(23)16-17)26-14-18-1-4-21(15-25-18)34(31,32)20-5-2-19(3-6-20)28-9-11-33-12-10-28/h1-8,13,15-16H,9-12,14H2,(H,26,30)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252533
PNG
(US9458172, 114 | US9458172, 136)
Show SMILES CCS(=O)(=O)c1cccc(c1)S(=O)(=O)c1ccc(CNC(=O)N2Cc3ccncc3C2)nc1
Show InChI InChI=1S/C22H22N4O5S2/c1-2-32(28,29)19-4-3-5-20(10-19)33(30,31)21-7-6-18(24-13-21)12-25-22(27)26-14-16-8-9-23-11-17(16)15-26/h3-11,13H,2,12,14-15H2,1H3,(H,25,27)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252533
PNG
(US9458172, 114 | US9458172, 136)
Show SMILES CCS(=O)(=O)c1cccc(c1)S(=O)(=O)c1ccc(CNC(=O)N2Cc3ccncc3C2)nc1
Show InChI InChI=1S/C22H22N4O5S2/c1-2-32(28,29)19-4-3-5-20(10-19)33(30,31)21-7-6-18(24-13-21)12-25-22(27)26-14-16-8-9-23-11-17(16)15-26/h3-11,13H,2,12,14-15H2,1H3,(H,25,27)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252475
PNG
(US9458172, 47)
Show SMILES CN1CCN(CC1)c1ccc(cn1)S(=O)(=O)c1ccc(CNC(=O)c2cnc3nccn3c2)nc1
Show InChI InChI=1S/C23H24N8O3S/c1-29-8-10-30(11-9-29)21-5-4-20(15-26-21)35(33,34)19-3-2-18(25-14-19)13-27-22(32)17-12-28-23-24-6-7-31(23)16-17/h2-7,12,14-16H,8-11,13H2,1H3,(H,27,32)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252495
PNG
(US9458172, 75)
Show SMILES CN(C)c1ncc(s1)S(=O)(=O)c1ccc(CNC(=O)c2cc3ccncc3s2)nc1
Show InChI InChI=1S/C19H17N5O3S3/c1-24(2)19-23-11-17(29-19)30(26,27)14-4-3-13(21-9-14)8-22-18(25)15-7-12-5-6-20-10-16(12)28-15/h3-7,9-11H,8H2,1-2H3,(H,22,25)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252476
PNG
(US9458172, 48)
Show SMILES CN1CCN(CC1)c1ccc(cc1)S(=O)(=O)c1ccc(CNC(=O)c2cnc3nccn3c2)nc1
Show InChI InChI=1S/C24H25N7O3S/c1-29-10-12-30(13-11-29)20-3-6-21(7-4-20)35(33,34)22-5-2-19(26-16-22)15-27-23(32)18-14-28-24-25-8-9-31(24)17-18/h2-9,14,16-17H,10-13,15H2,1H3,(H,27,32)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252490
PNG
(US9458172, 67)
Show SMILES CN(C)c1ccc(cn1)S(=O)(=O)c1ccc(CNC(=O)c2cc3ccncc3o2)nc1
Show InChI InChI=1S/C21H19N5O4S/c1-26(2)20-6-5-17(12-24-20)31(28,29)16-4-3-15(23-11-16)10-25-21(27)18-9-14-7-8-22-13-19(14)30-18/h3-9,11-13H,10H2,1-2H3,(H,25,27)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252489
PNG
(US9458172, 66)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)c1ccc(CNC(=O)c2cc3ccncc3o2)nc1
Show InChI InChI=1S/C22H19N3O6S/c1-29-18-6-5-16(10-19(18)30-2)32(27,28)17-4-3-15(24-12-17)11-25-22(26)20-9-14-7-8-23-13-21(14)31-20/h3-10,12-13H,11H2,1-2H3,(H,25,26)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252468
PNG
(US9458172, 39)
Show SMILES O=C(NCc1ccc(cn1)S(=O)(=O)c1ccc(cc1)N1CCOCC1)c1cc2ccncc2s1
Show InChI InChI=1S/C24H22N4O4S2/c29-24(22-13-17-7-8-25-16-23(17)33-22)27-14-18-1-4-21(15-26-18)34(30,31)20-5-2-19(3-6-20)28-9-11-32-12-10-28/h1-8,13,15-16H,9-12,14H2,(H,27,29)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252530
PNG
(US9458172, 111 | US9458172, 132)
Show SMILES FC(F)(F)CN1CCC(CC1)S(=O)(=O)c1ccc(CNC(=O)c2cnc3nccn3c2)nc1
Show InChI InChI=1S/C20H21F3N6O3S/c21-20(22,23)13-28-6-3-16(4-7-28)33(31,32)17-2-1-15(25-11-17)10-26-18(30)14-9-27-19-24-5-8-29(19)12-14/h1-2,5,8-9,11-12,16H,3-4,6-7,10,13H2,(H,26,30)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252530
PNG
(US9458172, 111 | US9458172, 132)
Show SMILES FC(F)(F)CN1CCC(CC1)S(=O)(=O)c1ccc(CNC(=O)c2cnc3nccn3c2)nc1
Show InChI InChI=1S/C20H21F3N6O3S/c21-20(22,23)13-28-6-3-16(4-7-28)33(31,32)17-2-1-15(25-11-17)10-26-18(30)14-9-27-19-24-5-8-29(19)12-14/h1-2,5,8-9,11-12,16H,3-4,6-7,10,13H2,(H,26,30)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252496
PNG
(US9458172, 76)
Show SMILES CCCn1cc(cn1)S(=O)(=O)c1ccc(CNC(=O)c2cc3ccncc3s2)nc1
Show InChI InChI=1S/C20H19N5O3S2/c1-2-7-25-13-17(11-24-25)30(27,28)16-4-3-15(22-10-16)9-23-20(26)18-8-14-5-6-21-12-19(14)29-18/h3-6,8,10-13H,2,7,9H2,1H3,(H,23,26)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252450
PNG
(US9458172, 20)
Show SMILES FC(F)(F)Oc1cccc(c1)S(=O)(=O)c1ccc(CNC(=O)c2cnc3nccn3c2)nc1
Show InChI InChI=1S/C20H14F3N5O4S/c21-20(22,23)32-15-2-1-3-16(8-15)33(30,31)17-5-4-14(25-11-17)10-26-18(29)13-9-27-19-24-6-7-28(19)12-13/h1-9,11-12H,10H2,(H,26,29)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252478
PNG
(US9458172, 50)
Show SMILES FC(F)(F)Oc1cccc(c1)S(=O)(=O)c1ccc(CNC(=O)N2Cc3ccncc3C2)nc1
Show InChI InChI=1S/C21H17F3N4O4S/c22-21(23,24)32-17-2-1-3-18(8-17)33(30,31)19-5-4-16(26-11-19)10-27-20(29)28-12-14-6-7-25-9-15(14)13-28/h1-9,11H,10,12-13H2,(H,27,29)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252466
PNG
(US9458172, 37)
Show SMILES O=C(NCc1ccc(cn1)S(=O)(=O)c1ccc(cc1)N1CCOCC1)c1cc2ccncc2o1
Show InChI InChI=1S/C24H22N4O5S/c29-24(22-13-17-7-8-25-16-23(17)33-22)27-14-18-1-4-21(15-26-18)34(30,31)20-5-2-19(3-6-20)28-9-11-32-12-10-28/h1-8,13,15-16H,9-12,14H2,(H,27,29)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252477
PNG
(US9458172, 49)
Show SMILES FC(F)(F)c1cccc(c1)S(=O)(=O)c1ccc(CNC(=O)N2Cc3ccncc3C2)nc1
Show InChI InChI=1S/C21H17F3N4O3S/c22-21(23,24)16-2-1-3-18(8-16)32(30,31)19-5-4-17(26-11-19)10-27-20(29)28-12-14-6-7-25-9-15(14)13-28/h1-9,11H,10,12-13H2,(H,27,29)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252462
PNG
(US9458172, 33)
Show SMILES COc1cccc(c1)S(=O)(=O)c1ccc(CNC(=O)c2cnc3nccn3c2)nc1
Show InChI InChI=1S/C20H17N5O4S/c1-29-16-3-2-4-17(9-16)30(27,28)18-6-5-15(22-12-18)11-23-19(26)14-10-24-20-21-7-8-25(20)13-14/h2-10,12-13H,11H2,1H3,(H,23,26)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252448
PNG
(US9458172, 18)
Show SMILES FC(F)(F)c1cccc(c1)S(=O)(=O)c1ccc(CNC(=O)c2cnc3nccn3c2)nc1
Show InChI InChI=1S/C20H14F3N5O3S/c21-20(22,23)14-2-1-3-16(8-14)32(30,31)17-5-4-15(25-11-17)10-26-18(29)13-9-27-19-24-6-7-28(19)12-13/h1-9,11-12H,10H2,(H,26,29)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252454
PNG
(US9458172, 25 | US9458172, 28 | US9458172, 29)
Show SMILES Fc1cc(F)cc(c1)S(=O)c1ccc(CNC(=O)c2cc3ccncc3o2)nc1
Show InChI InChI=1S/C20H13F2N3O3S/c21-13-6-14(22)8-17(7-13)29(27)16-2-1-15(24-10-16)9-25-20(26)18-5-12-3-4-23-11-19(12)28-18/h1-8,10-11H,9H2,(H,25,26)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252513
PNG
(US9458172, 93)
Show SMILES CN(C)c1ncc(s1)S(=O)(=O)c1ccc(CNC(=O)c2cc3ccncc3o2)nc1
Show InChI InChI=1S/C19H17N5O4S2/c1-24(2)19-23-11-17(29-19)30(26,27)14-4-3-13(21-9-14)8-22-18(25)15-7-12-5-6-20-10-16(12)28-15/h3-7,9-11H,8H2,1-2H3,(H,22,25)
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The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252550
PNG
(US9458172, 131)
Show SMILES FC(F)(F)CN1CCC(CC1)S(=O)(=O)c1ccc(CNC(=O)c2cc3ccncc3o2)nc1
Show InChI InChI=1S/C21H21F3N4O4S/c22-21(23,24)13-28-7-4-16(5-8-28)33(30,31)17-2-1-15(26-11-17)10-27-20(29)18-9-14-3-6-25-12-19(14)32-18/h1-3,6,9,11-12,16H,4-5,7-8,10,13H2,(H,27,29)
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The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252491
PNG
(US9458172, 69)
Show SMILES CN(C)c1ccc(cn1)S(=O)(=O)c1ccc(CNC(=O)c2cnc3nccn3c2)nc1
Show InChI InChI=1S/C20H19N7O3S/c1-26(2)18-6-5-17(12-23-18)31(29,30)16-4-3-15(22-11-16)10-24-19(28)14-9-25-20-21-7-8-27(20)13-14/h3-9,11-13H,10H2,1-2H3,(H,24,28)
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The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


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More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50060813
PNG
(CHEMBL3394734 | US9458172, 5)
Show SMILES Fc1cc(F)cc(c1)S(=O)(=O)c1ccc(CNC(=O)c2cc3ccncc3o2)nc1
Show InChI InChI=1S/C20H13F2N3O4S/c21-13-6-14(22)8-17(7-13)30(27,28)16-2-1-15(24-10-16)9-25-20(26)18-5-12-3-4-23-11-19(12)29-18/h1-8,10-11H,9H2,(H,25,26)
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The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


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More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252565
PNG
(US9458172, 146)
Show SMILES CCN(C)c1ncc(s1)S(=O)(=O)c1ccc(CNC(=O)c2cc3ccncc3o2)nc1
Show InChI InChI=1S/C21H19N5O4S/c1-3-26(2)20-25-12-18(31-20)21(28,29)14-4-5-15(23-9-14)10-24-19(27)16-8-13-6-7-22-11-17(13)30-16/h4-9,11-12H,3,10H2,1-2H3,(H,24,27)
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The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


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More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252508
PNG
(US9458172, 88)
Show SMILES Fc1cc(cc(c1)S(=O)(=O)c1ccc(CNC(=O)c2cc3ccncc3o2)nc1)N1CCOCC1
Show InChI InChI=1S/C24H21FN4O5S/c25-17-10-19(29-5-7-33-8-6-29)12-21(11-17)35(31,32)20-2-1-18(27-14-20)13-28-24(30)22-9-16-3-4-26-15-23(16)34-22/h1-4,9-12,14-15H,5-8,13H2,(H,28,30)
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The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


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More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252516
PNG
(US9458172, 97)
Show SMILES O=C(NCc1ccc(cn1)S(=O)(=O)c1ccc(cc1)N1CCOCC1)N1Cc2ccncc2C1
Show InChI InChI=1S/C24H25N5O4S/c30-24(29-16-18-7-8-25-13-19(18)17-29)27-14-20-1-4-23(15-26-20)34(31,32)22-5-2-21(3-6-22)28-9-11-33-12-10-28/h1-8,13,15H,9-12,14,16-17H2,(H,27,30)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


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More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252461
PNG
(US9458172, 32)
Show SMILES COc1cccc(c1)S(=O)(=O)c1ccc(CNC(=O)c2cc3ccncc3o2)nc1
Show InChI InChI=1S/C21H17N3O5S/c1-28-16-3-2-4-17(10-16)30(26,27)18-6-5-15(23-12-18)11-24-21(25)19-9-14-7-8-22-13-20(14)29-19/h2-10,12-13H,11H2,1H3,(H,24,25)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252452
PNG
(US9458172, 23)
Show SMILES FC(F)(F)Oc1cccc(c1)S(=O)(=O)c1ccc(CNC(=O)c2cc3ccncc3o2)nc1
Show InChI InChI=1S/C21H14F3N3O5S/c22-21(23,24)32-15-2-1-3-16(9-15)33(29,30)17-5-4-14(26-11-17)10-27-20(28)18-8-13-6-7-25-12-19(13)31-18/h1-9,11-12H,10H2,(H,27,28)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50060763
PNG
(CHEMBL3394741 | US9458172, 61)
Show SMILES CCCn1cc(cn1)S(=O)(=O)c1ccc(CNC(=O)c2cc3ccncc3o2)nc1
Show InChI InChI=1S/C20H19N5O4S/c1-2-7-25-13-17(11-24-25)30(27,28)16-4-3-15(22-10-16)9-23-20(26)18-8-14-5-6-21-12-19(14)29-18/h3-6,8,10-13H,2,7,9H2,1H3,(H,23,26)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252435
PNG
(US9458172, 2)
Show SMILES Fc1cc(F)cc(c1)S(=O)(=O)c1ccc(CNC(=O)c2cnc3nccn3c2)nc1
Show InChI InChI=1S/C19H13F2N5O3S/c20-13-5-14(21)7-17(6-13)30(28,29)16-2-1-15(23-10-16)9-24-18(27)12-8-25-19-22-3-4-26(19)11-12/h1-8,10-11H,9H2,(H,24,27)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50060814
PNG
(CHEMBL3394733 | US9458172, 22)
Show SMILES FC(F)(F)c1cccc(c1)S(=O)(=O)c1ccc(CNC(=O)c2cc3ccncc3o2)nc1
Show InChI InChI=1S/C21H14F3N3O4S/c22-21(23,24)14-2-1-3-16(9-14)32(29,30)17-5-4-15(26-11-17)10-27-20(28)18-8-13-6-7-25-12-19(13)31-18/h1-9,11-12H,10H2,(H,27,28)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252517
PNG
(US9458172, 98)
Show SMILES CN(C)c1ncc(s1)S(=O)(=O)c1ccc(CNC(=O)N2Cc3ccncc3C2)nc1
Show InChI InChI=1S/C19H20N6O3S2/c1-24(2)19-23-10-17(29-19)30(27,28)16-4-3-15(21-9-16)8-22-18(26)25-11-13-5-6-20-7-14(13)12-25/h3-7,9-10H,8,11-12H2,1-2H3,(H,22,26)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252528
PNG
(US9458172, 109 | US9458172, 115)
Show SMILES CCS(=O)(=O)c1cccc(c1)S(=O)(=O)c1ccc(CNC(=O)c2cc3ccncc3o2)nc1
Show InChI InChI=1S/C22H19N3O6S2/c1-2-32(27,28)17-4-3-5-18(11-17)33(29,30)19-7-6-16(24-13-19)12-25-22(26)20-10-15-8-9-23-14-21(15)31-20/h3-11,13-14H,2,12H2,1H3,(H,25,26)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


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More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252528
PNG
(US9458172, 109 | US9458172, 115)
Show SMILES CCS(=O)(=O)c1cccc(c1)S(=O)(=O)c1ccc(CNC(=O)c2cc3ccncc3o2)nc1
Show InChI InChI=1S/C22H19N3O6S2/c1-2-32(27,28)17-4-3-5-18(11-17)33(29,30)19-7-6-16(24-13-19)12-25-22(26)20-10-15-8-9-23-14-21(15)31-20/h3-11,13-14H,2,12H2,1H3,(H,25,26)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252566
PNG
(US9458172, 147)
Show SMILES CCN(C)c1ncc(s1)S(=O)(=O)c1ccc(CNC(=O)N2Cc3ccncc3C2)nc1
Show InChI InChI=1S/C20H22N6O3S2/c1-3-25(2)20-24-11-18(30-20)31(28,29)17-5-4-16(22-10-17)9-23-19(27)26-12-14-6-7-21-8-15(14)13-26/h4-8,10-11H,3,9,12-13H2,1-2H3,(H,23,27)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


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More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252474
PNG
(US9458172, 46)
Show SMILES CN1CCN(CC1)c1ccc(cn1)S(=O)(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)nc1
Show InChI InChI=1S/C24H25N7O3S/c1-29-10-12-30(13-11-29)23-7-5-21(16-27-23)35(33,34)20-4-3-19(26-15-20)14-28-24(32)18-2-6-22-25-8-9-31(22)17-18/h2-9,15-17H,10-14H2,1H3,(H,28,32)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


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More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252436
PNG
(US9458172, 4)
Show SMILES Fc1cc(F)cc(c1)S(=O)(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)nc1
Show InChI InChI=1S/C20H14F2N4O3S/c21-14-7-15(22)9-18(8-14)30(28,29)17-3-2-16(24-11-17)10-25-20(27)13-1-4-19-23-5-6-26(19)12-13/h1-9,11-12H,10H2,(H,25,27)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252459
PNG
(US9458172, 30)
Show SMILES O=C(NCc1ccc(cn1)S(=O)(=O)c1ccc(cc1)N1CCOCC1)c1ccc2nccn2c1
Show InChI InChI=1S/C24H23N5O4S/c30-24(18-1-8-23-25-9-10-29(23)17-18)27-15-19-2-5-22(16-26-19)34(31,32)21-6-3-20(4-7-21)28-11-13-33-14-12-28/h1-10,16-17H,11-15H2,(H,27,30)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50060764
PNG
(CHEMBL3394740 | US9458172, 45)
Show SMILES CC(C)n1cc(cn1)S(=O)(=O)c1ccc(CNC(=O)c2cc3ccncc3s2)nc1
Show InChI InChI=1S/C20H19N5O3S2/c1-13(2)25-12-17(10-24-25)30(27,28)16-4-3-15(22-9-16)8-23-20(26)18-7-14-5-6-21-11-19(14)29-18/h3-7,9-13H,8H2,1-2H3,(H,23,26)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252494
PNG
(US9458172, 74)
Show SMILES CN(C)c1ncc(s1)S(=O)(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)nc1
Show InChI InChI=1S/C19H18N6O3S2/c1-24(2)19-23-11-17(29-19)30(27,28)15-5-4-14(21-10-15)9-22-18(26)13-3-6-16-20-7-8-25(16)12-13/h3-8,10-12H,9H2,1-2H3,(H,22,26)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252509
PNG
(US9458172, 89)
Show SMILES FC(F)(F)Oc1cccc(c1)S(=O)c1ccc(CNC(=O)N2Cc3ccncc3C2)nc1
Show InChI InChI=1S/C21H17F3N4O3S/c22-21(23,24)31-17-2-1-3-18(8-17)32(30)19-5-4-16(26-11-19)10-27-20(29)28-12-14-6-7-25-9-15(14)13-28/h1-9,11H,10,12-13H2,(H,27,29)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252443
PNG
(US9458172, 13)
Show SMILES FC(F)(F)Oc1cccc(c1)S(=O)(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)nc1
Show InChI InChI=1S/C21H15F3N4O4S/c22-21(23,24)32-16-2-1-3-17(10-16)33(30,31)18-6-5-15(26-12-18)11-27-20(29)14-4-7-19-25-8-9-28(19)13-14/h1-10,12-13H,11H2,(H,27,29)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252464
PNG
(US9458172, 35)
Show SMILES O=C(NCc1ccc(cn1)S(=O)(=O)c1ccc(nc1)N1CCOCC1)c1ccc2nccn2c1
Show InChI InChI=1S/C23H22N6O4S/c30-23(17-1-5-21-24-7-8-29(21)16-17)27-13-18-2-3-19(14-25-18)34(31,32)20-4-6-22(26-15-20)28-9-11-33-12-10-28/h1-8,14-16H,9-13H2,(H,27,30)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252503
PNG
(US9458172, 83)
Show SMILES CN(C)c1ccc(cn1)S(=O)(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)nc1
Show InChI InChI=1S/C21H20N6O3S/c1-26(2)19-8-6-18(13-24-19)31(29,30)17-5-4-16(23-12-17)11-25-21(28)15-3-7-20-22-9-10-27(20)14-15/h3-10,12-14H,11H2,1-2H3,(H,25,28)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252557
PNG
(US9458172, 138)
Show SMILES O=C(NCc1ccc(cn1)S(=O)(=O)c1cnc(s1)N1CCCC1)c1cc2ccncc2o1
Show InChI InChI=1S/C21H19N5O4S2/c27-20(17-9-14-5-6-22-12-18(14)30-17)24-10-15-3-4-16(11-23-15)32(28,29)19-13-25-21(31-19)26-7-1-2-8-26/h3-6,9,11-13H,1-2,7-8,10H2,(H,24,27)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


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More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252564
PNG
(US9458172, 145)
Show SMILES CCN(C)c1ncc(s1)S(=O)(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)nc1
Show InChI InChI=1S/C20H20N6O3S2/c1-3-25(2)20-24-12-18(30-20)31(28,29)16-6-5-15(22-11-16)10-23-19(27)14-4-7-17-21-8-9-26(17)13-14/h4-9,11-13H,3,10H2,1-2H3,(H,23,27)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


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More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252519
PNG
(US9458172, 100)
Show SMILES Fc1cccc(c1)S(=O)(=O)c1ccc(CNC(=O)N2Cc3ccncc3C2)nc1
Show InChI InChI=1S/C20H17FN4O3S/c21-16-2-1-3-18(8-16)29(27,28)19-5-4-17(23-11-19)10-24-20(26)25-12-14-6-7-22-9-15(14)13-25/h1-9,11H,10,12-13H2,(H,24,26)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50060767
PNG
(CHEMBL3394737 | US9458172, 94)
Show SMILES Cc1ccc(cn1)S(=O)(=O)c1ccc(CNC(=O)c2cc3ccncc3o2)nc1
Show InChI InChI=1S/C20H16N4O4S/c1-13-2-4-16(10-22-13)29(26,27)17-5-3-15(23-11-17)9-24-20(25)18-8-14-6-7-21-12-19(14)28-18/h2-8,10-12H,9H2,1H3,(H,24,25)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252539
PNG
(US9458172, 120)
Show SMILES FC(F)(F)c1cccc(c1)S(=O)c1ccc(CNC(=O)N2Cc3ccncc3C2)nc1
Show InChI InChI=1S/C21H17F3N4O2S/c22-21(23,24)16-2-1-3-18(8-16)31(30)19-5-4-17(26-11-19)10-27-20(29)28-12-14-6-7-25-9-15(14)13-28/h1-9,11H,10,12-13H2,(H,27,29)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252559
PNG
(US9458172, 140)
Show SMILES CCCn1cc(cn1)S(=O)(=O)c1ccc(CNC(=O)N2Cc3ccncc3C2)nc1
Show InChI InChI=1S/C20H22N6O3S/c1-2-7-26-14-19(11-24-26)30(28,29)18-4-3-17(22-10-18)9-23-20(27)25-12-15-5-6-21-8-16(15)13-25/h3-6,8,10-11,14H,2,7,9,12-13H2,1H3,(H,23,27)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252451
PNG
(US9458172, 21)
Show SMILES FC(F)(F)Oc1cccc(c1)S(=O)(=O)c1ccc(CNC(=O)c2cc3cnccc3[nH]2)nc1
Show InChI InChI=1S/C21H15F3N4O4S/c22-21(23,24)32-15-2-1-3-16(9-15)33(30,31)17-5-4-14(26-12-17)11-27-20(29)19-8-13-10-25-7-6-18(13)28-19/h1-10,12,28H,11H2,(H,27,29)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252501
PNG
(US9458172, 81)
Show SMILES FC(F)(F)c1cccc(c1)S(=O)(=O)c1cnc(CNC(=O)c2cc3ccncc3o2)nc1
Show InChI InChI=1S/C20H13F3N4O4S/c21-20(22,23)13-2-1-3-14(7-13)32(29,30)15-8-25-18(26-9-15)11-27-19(28)16-6-12-4-5-24-10-17(12)31-16/h1-10H,11H2,(H,27,28)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252441
PNG
(US9458172, 10)
Show SMILES FC(F)(F)c1cccc(c1)S(=O)(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)nc1
Show InChI InChI=1S/C21H15F3N4O3S/c22-21(23,24)15-2-1-3-17(10-15)32(30,31)18-6-5-16(26-12-18)11-27-20(29)14-4-7-19-25-8-9-28(19)13-14/h1-10,12-13H,11H2,(H,27,29)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


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More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252543
PNG
(US9458172, 124)
Show SMILES CS(=O)(=O)c1cccc(c1)S(=O)(=O)c1ccc(CNC(=O)c2cc3ccncc3o2)nc1
Show InChI InChI=1S/C21H17N3O6S2/c1-31(26,27)16-3-2-4-17(10-16)32(28,29)18-6-5-15(23-12-18)11-24-21(25)19-9-14-7-8-22-13-20(14)30-19/h2-10,12-13H,11H2,1H3,(H,24,25)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252529
PNG
(US9458172, 110 | US9458172, 117)
Show SMILES Nc1ccc(cn1)S(=O)(=O)c1ccc(CNC(=O)c2cc3ccncc3o2)nc1
Show InChI InChI=1S/C19H15N5O4S/c20-18-4-3-15(10-23-18)29(26,27)14-2-1-13(22-9-14)8-24-19(25)16-7-12-5-6-21-11-17(12)28-16/h1-7,9-11H,8H2,(H2,20,23)(H,24,25)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252529
PNG
(US9458172, 110 | US9458172, 117)
Show SMILES Nc1ccc(cn1)S(=O)(=O)c1ccc(CNC(=O)c2cc3ccncc3o2)nc1
Show InChI InChI=1S/C19H15N5O4S/c20-18-4-3-15(10-23-18)29(26,27)14-2-1-13(22-9-14)8-24-19(25)16-7-12-5-6-21-11-17(12)28-16/h1-7,9-11H,8H2,(H2,20,23)(H,24,25)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


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More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252544
PNG
(US9458172, 125)
Show SMILES O=C(NCc1ccc(cn1)S(=O)(=O)c1ccc(nc1)N1CCOCC1)N1Cc2ccncc2C1
Show InChI InChI=1S/C23H24N6O4S/c30-23(29-15-17-5-6-24-11-18(17)16-29)27-12-19-1-2-20(13-25-19)34(31,32)21-3-4-22(26-14-21)28-7-9-33-10-8-28/h1-6,11,13-14H,7-10,12,15-16H2,(H,27,30)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252558
PNG
(US9458172, 139)
Show SMILES COc1cc(OC)cc(c1)S(=O)(=O)c1ccc(CNC(=O)C2CN=c3[nH]ncc3=C2)nc1
Show InChI InChI=1S/C21H21N5O5S/c1-30-16-6-17(31-2)8-19(7-16)32(28,29)18-4-3-15(22-12-18)11-24-21(27)14-5-13-10-25-26-20(13)23-9-14/h3-8,10,12,14H,9,11H2,1-2H3,(H,23,26)(H,24,27)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252535
PNG
(US9458172, 116 | US9458172, 159 | US9458172, 160)
Show SMILES Fc1cc(F)cc(c1)S(=O)c1ccc(CNC(=O)N2Cc3ccncc3C2)nc1
Show InChI InChI=1S/C20H16F2N4O2S/c21-15-5-16(22)7-19(6-15)29(28)18-2-1-17(24-10-18)9-25-20(27)26-11-13-3-4-23-8-14(13)12-26/h1-8,10H,9,11-12H2,(H,25,27)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252444
PNG
(US9458172, 14 | US9458172, 55 | US9458172, 58)
Show SMILES Fc1cc(F)cc(c1)S(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)nc1
Show InChI InChI=1S/C20H14F2N4O2S/c21-14-7-15(22)9-18(8-14)29(28)17-3-2-16(24-11-17)10-25-20(27)13-1-4-19-23-5-6-26(19)12-13/h1-9,11-12H,10H2,(H,25,27)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252510
PNG
(US9458172, 90)
Show SMILES FC(F)(F)Oc1cccc(c1)S(=O)c1ccc(CNC(=O)c2cc3ccncc3o2)nc1
Show InChI InChI=1S/C21H14F3N3O4S/c22-21(23,24)31-15-2-1-3-16(9-15)32(29)17-5-4-14(26-11-17)10-27-20(28)18-8-13-6-7-25-12-19(13)30-18/h1-9,11-12H,10H2,(H,27,28)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252453
PNG
(US9458172, 24)
Show SMILES Fc1cc(F)cc(c1)S(=O)c1ccc(CNC(=O)c2cnc3nccn3c2)nc1
Show InChI InChI=1S/C19H13F2N5O2S/c20-13-5-14(21)7-17(6-13)29(28)16-2-1-15(23-10-16)9-24-18(27)12-8-25-19-22-3-4-26(19)11-12/h1-8,10-11H,9H2,(H,24,27)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252553
PNG
(US9458172, 134)
Show SMILES CS(=O)(=O)c1cccc(c1)S(=O)(=O)c1ccc(CNC(=O)c2cnc3[nH]ncc3c2)nc1
Show InChI InChI=1S/C20H17N5O5S2/c1-31(27,28)16-3-2-4-17(8-16)32(29,30)18-6-5-15(21-12-18)11-23-20(26)14-7-13-10-24-25-19(13)22-9-14/h2-10,12H,11H2,1H3,(H,23,26)(H,22,24,25)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252493
PNG
(US9458172, 73)
Show SMILES Fc1cc(F)cc(c1)S(=O)(=O)c1ccc(CNC(=O)N2Cc3ccncc3C2)nc1
Show InChI InChI=1S/C20H16F2N4O3S/c21-15-5-16(22)7-19(6-15)30(28,29)18-2-1-17(24-10-18)9-25-20(27)26-11-13-3-4-23-8-14(13)12-26/h1-8,10H,9,11-12H2,(H,25,27)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252497
PNG
(US9458172, 77)
Show SMILES FC(F)(F)c1cccc(c1)S(=O)(=O)c1cnc(CNC(=O)c2ccc3nccn3c2)nc1
Show InChI InChI=1S/C20H14F3N5O3S/c21-20(22,23)14-2-1-3-15(8-14)32(30,31)16-9-25-17(26-10-16)11-27-19(29)13-4-5-18-24-6-7-28(18)12-13/h1-10,12H,11H2,(H,27,29)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252507
PNG
(US9458172, 87)
Show SMILES FC(F)(F)c1cccc(c1)S(=O)c1ccc(CNC(=O)c2cc3ccncc3o2)nc1
Show InChI InChI=1S/C21H14F3N3O3S/c22-21(23,24)14-2-1-3-16(9-14)31(29)17-5-4-15(26-11-17)10-27-20(28)18-8-13-6-7-25-12-19(13)30-18/h1-9,11-12H,10H2,(H,27,28)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252532
PNG
(US9458172, 113 | US9458172, 135)
Show SMILES CN1CCN(CC1)c1ccc(cn1)S(=O)(=O)c1ccc(CNC(=O)c2cc3ccncc3o2)nc1
Show InChI InChI=1S/C24H24N6O4S/c1-29-8-10-30(11-9-29)23-5-4-20(15-27-23)35(32,33)19-3-2-18(26-14-19)13-28-24(31)21-12-17-6-7-25-16-22(17)34-21/h2-7,12,14-16H,8-11,13H2,1H3,(H,28,31)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252470
PNG
(US9458172, 41)
Show SMILES O=C(NCc1ccc(cn1)S(=O)(=O)c1ccc(nc1)N1CCOCC1)c1cnc2[nH]ncc2c1
Show InChI InChI=1S/C22H21N7O4S/c30-22(16-9-15-11-27-28-21(15)25-10-16)26-12-17-1-2-18(13-23-17)34(31,32)19-3-4-20(24-14-19)29-5-7-33-8-6-29/h1-4,9-11,13-14H,5-8,12H2,(H,26,30)(H,25,27,28)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252442
PNG
(US9458172, 12)
Show SMILES O=C(NCc1ncc(cn1)S(=O)(=O)c1ccccc1)c1cnc2nccn2c1
Show InChI InChI=1S/C18H14N6O3S/c25-17(13-8-23-18-19-6-7-24(18)12-13)22-11-16-20-9-15(10-21-16)28(26,27)14-4-2-1-3-5-14/h1-10,12H,11H2,(H,22,25)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252447
PNG
(US9458172, 17)
Show SMILES FC(F)(F)c1cccc(c1)S(=O)(=O)c1ccc(CNC(=O)c2cc3cnccc3[nH]2)nc1
Show InChI InChI=1S/C21H15F3N4O3S/c22-21(23,24)14-2-1-3-16(9-14)32(30,31)17-5-4-15(26-12-17)11-27-20(29)19-8-13-10-25-7-6-18(13)28-19/h1-10,12,28H,11H2,(H,27,29)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252460
PNG
(US9458172, 31)
Show SMILES O=C(NCc1ccc(cn1)S(=O)(=O)c1ccc(cc1)N1CCOCC1)c1cnc2[nH]ncc2c1
Show InChI InChI=1S/C23H22N6O4S/c30-23(17-11-16-13-27-28-22(16)25-12-17)26-14-18-1-4-21(15-24-18)34(31,32)20-5-2-19(3-6-20)29-7-9-33-10-8-29/h1-6,11-13,15H,7-10,14H2,(H,26,30)(H,25,27,28)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252515
PNG
(US9458172, 96)
Show SMILES CCS(=O)(=O)c1cccc(c1)S(=O)(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)nc1
Show InChI InChI=1S/C22H20N4O5S2/c1-2-32(28,29)18-4-3-5-19(12-18)33(30,31)20-8-7-17(24-14-20)13-25-22(27)16-6-9-21-23-10-11-26(21)15-16/h3-12,14-15H,2,13H2,1H3,(H,25,27)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50060812
PNG
(CHEMBL3394735 | US9458172, 3)
Show SMILES Fc1cc(F)cc(c1)S(=O)(=O)c1ccc(CNC(=O)c2cc3cnccc3[nH]2)nc1
Show InChI InChI=1S/C20H14F2N4O3S/c21-13-6-14(22)8-17(7-13)30(28,29)16-2-1-15(24-11-16)10-25-20(27)19-5-12-9-23-4-3-18(12)26-19/h1-9,11,26H,10H2,(H,25,27)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252535
PNG
(US9458172, 116 | US9458172, 159 | US9458172, 160)
Show SMILES Fc1cc(F)cc(c1)S(=O)c1ccc(CNC(=O)N2Cc3ccncc3C2)nc1
Show InChI InChI=1S/C20H16F2N4O2S/c21-15-5-16(22)7-19(6-15)29(28)18-2-1-17(24-10-18)9-25-20(27)26-11-13-3-4-23-8-14(13)12-26/h1-8,10H,9,11-12H2,(H,25,27)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252601
PNG
(US9458172, 185)
Show SMILES O=C(NCc1ccc(cn1)S(=O)(=O)c1ccccc1)c1cnc2nccn2c1
Show InChI InChI=1S/C19H15N5O3S/c25-18(14-10-23-19-20-8-9-24(19)13-14)22-11-15-6-7-17(12-21-15)28(26,27)16-4-2-1-3-5-16/h1-10,12-13H,11H2,(H,22,25)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252499
PNG
(US9458172, 79)
Show SMILES FC(F)(F)c1ccc(cn1)S(=O)(=O)c1ccc(CNC(=O)c2cc3ccncc3o2)nc1
Show InChI InChI=1S/C20H13F3N4O4S/c21-20(22,23)18-4-3-15(10-26-18)32(29,30)14-2-1-13(25-9-14)8-27-19(28)16-7-12-5-6-24-11-17(12)31-16/h1-7,9-11H,8H2,(H,27,28)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252454
PNG
(US9458172, 25 | US9458172, 28 | US9458172, 29)
Show SMILES Fc1cc(F)cc(c1)S(=O)c1ccc(CNC(=O)c2cc3ccncc3o2)nc1
Show InChI InChI=1S/C20H13F2N3O3S/c21-13-6-14(22)8-17(7-13)29(27)16-2-1-15(24-10-16)9-25-20(26)18-5-12-3-4-23-11-19(12)28-18/h1-8,10-11H,9H2,(H,25,26)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252542
PNG
(US9458172, 123)
Show SMILES O=C(NCc1ccc(cn1)S(=O)(=O)c1cccc(c1)N1CCOCC1)c1cc2ccncc2o1
Show InChI InChI=1S/C24H22N4O5S/c29-24(22-12-17-6-7-25-16-23(17)33-22)27-14-18-4-5-21(15-26-18)34(30,31)20-3-1-2-19(13-20)28-8-10-32-11-9-28/h1-7,12-13,15-16H,8-11,14H2,(H,27,29)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


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More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252500
PNG
(US9458172, 80)
Show SMILES CC(C)n1cc(cn1)S(=O)(=O)c1ccc(CNC(=O)N2Cc3ccncc3C2)nc1
Show InChI InChI=1S/C20H22N6O3S/c1-14(2)26-13-19(10-24-26)30(28,29)18-4-3-17(22-9-18)8-23-20(27)25-11-15-5-6-21-7-16(15)12-25/h3-7,9-10,13-14H,8,11-12H2,1-2H3,(H,23,27)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252586
PNG
(US9458172, 167)
Show SMILES O=C(NCc1ccc(cn1)S(=O)(=O)c1cnc(nc1)N1CCOCC1)c1ccc2nccn2c1
Show InChI InChI=1S/C22H21N7O4S/c30-21(16-1-4-20-23-5-6-29(20)15-16)25-11-17-2-3-18(12-24-17)34(31,32)19-13-26-22(27-14-19)28-7-9-33-10-8-28/h1-6,12-15H,7-11H2,(H,25,30)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252599
PNG
(US9458172, 182)
Show SMILES Fc1cc(F)cc(c1)S(=O)(=O)c1cnc(CNC(=O)c2cc3ccncc3o2)nc1
Show InChI InChI=1S/C19H12F2N4O4S/c20-12-4-13(21)6-14(5-12)30(27,28)15-7-23-18(24-8-15)10-25-19(26)16-3-11-1-2-22-9-17(11)29-16/h1-9H,10H2,(H,25,26)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252484
PNG
(US9458172, 56)
Show SMILES O=C(NCc1ccc(cn1)S(=O)(=O)C1CCN(CC1)C1COC1)c1cc2ccncc2s1
Show InChI InChI=1S/C22H24N4O4S2/c27-22(20-9-15-3-6-23-12-21(15)31-20)25-10-16-1-2-19(11-24-16)32(28,29)18-4-7-26(8-5-18)17-13-30-14-17/h1-3,6,9,11-12,17-18H,4-5,7-8,10,13-14H2,(H,25,27)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252563
PNG
(US9458172, 144)
Show SMILES COc1cc(F)cc(c1)S(=O)(=O)c1ccc(CNC(=O)c2cnc3[nH]ncc3c2)nc1
Show InChI InChI=1S/C20H16FN5O4S/c1-30-16-5-14(21)6-18(7-16)31(28,29)17-3-2-15(22-11-17)10-24-20(27)13-4-12-9-25-26-19(12)23-8-13/h2-9,11H,10H2,1H3,(H,24,27)(H,23,25,26)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252472
PNG
(US9458172, 43)
Show SMILES CCCn1cc(cn1)S(=O)(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)nc1
Show InChI InChI=1S/C20H20N6O3S/c1-2-8-26-14-18(12-24-26)30(28,29)17-5-4-16(22-11-17)10-23-20(27)15-3-6-19-21-7-9-25(19)13-15/h3-7,9,11-14H,2,8,10H2,1H3,(H,23,27)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252486
PNG
(US9458172, 59)
Show SMILES O=C(NCc1ccc(cn1)S(=O)(=O)C1CCCCC1)N1Cc2ccncc2C1
Show InChI InChI=1S/C20H24N4O3S/c25-20(24-13-15-8-9-21-10-16(15)14-24)23-11-17-6-7-19(12-22-17)28(26,27)18-4-2-1-3-5-18/h6-10,12,18H,1-5,11,13-14H2,(H,23,25)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252527
PNG
(US9458172, 108)
Show SMILES CCCC(=O)N1CCC(CC1)S(=O)(=O)c1ccc(CNC(=O)N2Cc3ccncc3C2)nc1
Show InChI InChI=1S/C23H29N5O4S/c1-2-3-22(29)27-10-7-20(8-11-27)33(31,32)21-5-4-19(25-14-21)13-26-23(30)28-15-17-6-9-24-12-18(17)16-28/h4-6,9,12,14,20H,2-3,7-8,10-11,13,15-16H2,1H3,(H,26,30)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252504
PNG
(US9458172, 84)
Show SMILES CN(C)c1ccc(cn1)S(=O)(=O)c1ccc(CNC(=O)c2cnc3[nH]ncc3c2)nc1
Show InChI InChI=1S/C20H19N7O3S/c1-27(2)18-6-5-17(12-22-18)31(29,30)16-4-3-15(21-11-16)10-24-20(28)14-7-13-9-25-26-19(13)23-8-14/h3-9,11-12H,10H2,1-2H3,(H,24,28)(H,23,25,26)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252473
PNG
(US9458172, 44)
Show SMILES CC(C)n1cc(cn1)S(=O)(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)nc1
Show InChI InChI=1S/C20H20N6O3S/c1-14(2)26-13-18(11-24-26)30(28,29)17-5-4-16(22-10-17)9-23-20(27)15-3-6-19-21-7-8-25(19)12-15/h3-8,10-14H,9H2,1-2H3,(H,23,27)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252488
PNG
(US9458172, 65)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)nc1
Show InChI InChI=1S/C22H20N4O5S/c1-30-19-7-6-17(11-20(19)31-2)32(28,29)18-5-4-16(24-13-18)12-25-22(27)15-3-8-21-23-9-10-26(21)14-15/h3-11,13-14H,12H2,1-2H3,(H,25,27)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252520
PNG
(US9458172, 101)
Show SMILES FC(F)(F)Oc1cccc(c1)S(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)nc1
Show InChI InChI=1S/C21H15F3N4O3S/c22-21(23,24)31-16-2-1-3-17(10-16)32(30)18-6-5-15(26-12-18)11-27-20(29)14-4-7-19-25-8-9-28(19)13-14/h1-10,12-13H,11H2,(H,27,29)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252595
PNG
(US9458172, 177)
Show SMILES CCn1cc(cn1)S(=O)(=O)c1ccc(CNC(=O)N2Cc3ccncc3C2)nc1
Show InChI InChI=1S/C19H20N6O3S/c1-2-25-13-18(10-23-25)29(27,28)17-4-3-16(21-9-17)8-22-19(26)24-11-14-5-6-20-7-15(14)12-24/h3-7,9-10,13H,2,8,11-12H2,1H3,(H,22,26)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252548
PNG
(US9458172, 129)
Show SMILES O=C(NCc1ccc(cn1)S(=O)(=O)C1CCN(CC1)C1CCOC1)N1Cc2ccncc2C1
Show InChI InChI=1S/C23H29N5O4S/c29-23(28-14-17-3-7-24-11-18(17)15-28)26-12-19-1-2-22(13-25-19)33(30,31)21-4-8-27(9-5-21)20-6-10-32-16-20/h1-3,7,11,13,20-21H,4-6,8-10,12,14-16H2,(H,26,29)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252505
PNG
(US9458172, 85)
Show SMILES Fc1cc(cc(c1)S(=O)(=O)c1ccc(CNC(=O)c2cnc3[nH]ncc3c2)nc1)N1CCOCC1
Show InChI InChI=1S/C23H21FN6O4S/c24-17-8-19(30-3-5-34-6-4-30)10-21(9-17)35(32,33)20-2-1-18(25-14-20)13-27-23(31)16-7-15-12-28-29-22(15)26-11-16/h1-2,7-12,14H,3-6,13H2,(H,27,31)(H,26,28,29)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252512
PNG
(US9458172, 92)
Show SMILES Cc1ccc(cn1)S(=O)(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)nc1
Show InChI InChI=1S/C20H17N5O3S/c1-14-2-5-17(11-22-14)29(27,28)18-6-4-16(23-12-18)10-24-20(26)15-3-7-19-21-8-9-25(19)13-15/h2-9,11-13H,10H2,1H3,(H,24,26)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252444
PNG
(US9458172, 14 | US9458172, 55 | US9458172, 58)
Show SMILES Fc1cc(F)cc(c1)S(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)nc1
Show InChI InChI=1S/C20H14F2N4O2S/c21-14-7-15(22)9-18(8-14)29(28)17-3-2-16(24-11-17)10-25-20(27)13-1-4-19-23-5-6-26(19)12-13/h1-9,11-12H,10H2,(H,25,27)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


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More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252538
PNG
(US9458172, 119)
Show SMILES O=C(NCc1ccc(cn1)S(=O)(=O)C1CCN(CC1)C1CCOCC1)N1Cc2ccncc2C1
Show InChI InChI=1S/C24H31N5O4S/c30-24(29-16-18-3-8-25-13-19(18)17-29)27-14-20-1-2-23(15-26-20)34(31,32)22-4-9-28(10-5-22)21-6-11-33-12-7-21/h1-3,8,13,15,21-22H,4-7,9-12,14,16-17H2,(H,27,30)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


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More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252514
PNG
(US9458172, 95)
Show SMILES Cc1ccc(cn1)S(=O)(=O)c1ccc(CNC(=O)c2cc3ccncc3s2)nc1
Show InChI InChI=1S/C20H16N4O3S2/c1-13-2-4-16(10-22-13)29(26,27)17-5-3-15(23-11-17)9-24-20(25)18-8-14-6-7-21-12-19(14)28-18/h2-8,10-12H,9H2,1H3,(H,24,25)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


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More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50060815
PNG
(CHEMBL3394732 | US9458172, 183)
Show SMILES O=C(NCc1ccc(cn1)S(=O)(=O)c1ccccc1)c1cc2ccncc2o1
Show InChI InChI=1S/C20H15N3O4S/c24-20(18-10-14-8-9-21-13-19(14)27-18)23-11-15-6-7-17(12-22-15)28(25,26)16-4-2-1-3-5-16/h1-10,12-13H,11H2,(H,23,24)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


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More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252446
PNG
(US9458172, 16)
Show SMILES FC(F)(F)c1cccc(c1)S(=O)(=O)c1ccc(CNC(=O)c2cnc3[nH]ncc3c2)nc1
Show InChI InChI=1S/C20H14F3N5O3S/c21-20(22,23)14-2-1-3-16(7-14)32(30,31)17-5-4-15(24-11-17)10-26-19(29)13-6-12-9-27-28-18(12)25-8-13/h1-9,11H,10H2,(H,26,29)(H,25,27,28)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


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More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252573
PNG
(US9458172, 154)
Show SMILES O=C(NCc1ccc(cn1)S(=O)(=O)c1cccc(c1)N1CCOCC1)c1ccc2nccn2c1
Show InChI InChI=1S/C24H23N5O4S/c30-24(18-4-7-23-25-8-9-29(23)17-18)27-15-19-5-6-22(16-26-19)34(31,32)21-3-1-2-20(14-21)28-10-12-33-13-11-28/h1-9,14,16-17H,10-13,15H2,(H,27,30)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252549
PNG
(US9458172, 130)
Show SMILES CCCC(=O)N1CCC(CC1)S(=O)(=O)c1ccc(CNC(=O)c2cc3ccncc3o2)nc1
Show InChI InChI=1S/C23H26N4O5S/c1-2-3-22(28)27-10-7-18(8-11-27)33(30,31)19-5-4-17(25-14-19)13-26-23(29)20-12-16-6-9-24-15-21(16)32-20/h4-6,9,12,14-15,18H,2-3,7-8,10-11,13H2,1H3,(H,26,29)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50060816
PNG
(CHEMBL3394731 | US9458172, 11)
Show SMILES O=C(NCc1ncc(cn1)S(=O)(=O)c1ccccc1)c1cc2ccncc2o1
Show InChI InChI=1S/C19H14N4O4S/c24-19(16-8-13-6-7-20-11-17(13)27-16)23-12-18-21-9-15(10-22-18)28(25,26)14-4-2-1-3-5-14/h1-11H,12H2,(H,23,24)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252511
PNG
(US9458172, 91)
Show SMILES O=C(NCc1ccc(cn1)S(=O)(=O)N1CCC(CC1)N1CCCC1)c1cc2ccncc2o1
Show InChI InChI=1S/C23H27N5O4S/c29-23(21-13-17-5-8-24-16-22(17)32-21)26-14-18-3-4-20(15-25-18)33(30,31)28-11-6-19(7-12-28)27-9-1-2-10-27/h3-5,8,13,15-16,19H,1-2,6-7,9-12,14H2,(H,26,29)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


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More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252492
PNG
(US9458172, 70)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)c1ccc(CNC(=O)c2cnc3[nH]ncc3c2)nc1
Show InChI InChI=1S/C21H19N5O5S/c1-30-18-6-5-16(8-19(18)31-2)32(28,29)17-4-3-15(22-12-17)11-24-21(27)14-7-13-10-25-26-20(13)23-9-14/h3-10,12H,11H2,1-2H3,(H,24,27)(H,23,25,26)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252589
PNG
(US9458172, 170)
Show SMILES FC(F)(F)c1cncc(c1)S(=O)(=O)c1ccc(CNC(=O)N2Cc3ccncc3C2)nc1
Show InChI InChI=1S/C20H16F3N5O3S/c21-20(22,23)15-5-18(9-25-7-15)32(30,31)17-2-1-16(26-10-17)8-27-19(29)28-11-13-3-4-24-6-14(13)12-28/h1-7,9-10H,8,11-12H2,(H,27,29)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252546
PNG
(US9458172, 127)
Show SMILES O=C(NCc1ccc(cn1)S(=O)(=O)N1CCN(CC1)C1CCOCC1)c1cc2ccncc2o1
Show InChI InChI=1S/C23H27N5O5S/c29-23(21-13-17-3-6-24-16-22(17)33-21)26-14-18-1-2-20(15-25-18)34(30,31)28-9-7-27(8-10-28)19-4-11-32-12-5-19/h1-3,6,13,15-16,19H,4-5,7-12,14H2,(H,26,29)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


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More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252582
PNG
(US9458172, 163)
Show SMILES FC(F)(F)c1cncc(c1)S(=O)(=O)c1ccc(CNC(=O)c2cc3ccncc3o2)nc1
Show InChI InChI=1S/C20H13F3N4O4S/c21-20(22,23)13-6-16(9-25-7-13)32(29,30)15-2-1-14(26-10-15)8-27-19(28)17-5-12-3-4-24-11-18(12)31-17/h1-7,9-11H,8H2,(H,27,28)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


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More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252449
PNG
(US9458172, 19)
Show SMILES FC(F)(F)Oc1cccc(c1)S(=O)(=O)c1ccc(CNC(=O)c2cnc3[nH]ncc3c2)nc1
Show InChI InChI=1S/C20H14F3N5O4S/c21-20(22,23)32-15-2-1-3-16(7-15)33(30,31)17-5-4-14(24-11-17)10-26-19(29)13-6-12-9-27-28-18(12)25-8-13/h1-9,11H,10H2,(H,26,29)(H,25,27,28)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


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More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252594
PNG
(US9458172, 176)
Show SMILES CCn1cc(cn1)S(=O)(=O)c1ccc(CNC(=O)c2cc3ccncc3o2)nc1
Show InChI InChI=1S/C19H17N5O4S/c1-2-24-12-16(10-23-24)29(26,27)15-4-3-14(21-9-15)8-22-19(25)17-7-13-5-6-20-11-18(13)28-17/h3-7,9-12H,2,8H2,1H3,(H,22,25)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252524
PNG
(US9458172, 105)
Show SMILES O=C(NCc1ccc(cn1)S(=O)(=O)C1CCN(CC1)C1CCOCC1)c1cc2ccncc2o1
Show InChI InChI=1S/C24H28N4O5S/c29-24(22-13-17-3-8-25-16-23(17)33-22)27-14-18-1-2-21(15-26-18)34(30,31)20-4-9-28(10-5-20)19-6-11-32-12-7-19/h1-3,8,13,15-16,19-20H,4-7,9-12,14H2,(H,27,29)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252518
PNG
(US9458172, 99)
Show SMILES Cn1cc(cn1)S(=O)(=O)c1ccc(CNC(=O)N2Cc3ccncc3C2)nc1
Show InChI InChI=1S/C18H18N6O3S/c1-23-12-17(9-22-23)28(26,27)16-3-2-15(20-8-16)7-21-18(25)24-10-13-4-5-19-6-14(13)11-24/h2-6,8-9,12H,7,10-11H2,1H3,(H,21,25)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


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More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252570
PNG
(US9458172, 151)
Show SMILES O=C(NCc1ccc(cn1)S(=O)(=O)c1cccc(c1)C#N)c1cc2ccncc2o1
Show InChI InChI=1S/C21H14N4O4S/c22-10-14-2-1-3-17(8-14)30(27,28)18-5-4-16(24-12-18)11-25-21(26)19-9-15-6-7-23-13-20(15)29-19/h1-9,12-13H,11H2,(H,25,26)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252522
PNG
(US9458172, 103)
Show SMILES O=C(NCc1ccc(cn1)S(=O)(=O)C1CCN(CC1)C1COC1)c1cc2ccncc2o1
Show InChI InChI=1S/C22H24N4O5S/c27-22(20-9-15-3-6-23-12-21(15)31-20)25-10-16-1-2-19(11-24-16)32(28,29)18-4-7-26(8-5-18)17-13-30-14-17/h1-3,6,9,11-12,17-18H,4-5,7-8,10,13-14H2,(H,25,27)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252440
PNG
(US9458172, 9)
Show SMILES Fc1cc(F)cc(c1)S(=O)c1ccc(CNC(=O)c2cc3cnccc3[nH]2)nc1
Show InChI InChI=1S/C20H14F2N4O2S/c21-13-6-14(22)8-17(7-13)29(28)16-2-1-15(24-11-16)10-25-20(27)19-5-12-9-23-4-3-18(12)26-19/h1-9,11,26H,10H2,(H,25,27)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50060766
PNG
(CHEMBL3394738 | US9458172, 62)
Show SMILES CC(C)n1cc(cn1)S(=O)(=O)c1ccc(CNC(=O)c2cc3ccncc3o2)nc1
Show InChI InChI=1S/C20H19N5O4S/c1-13(2)25-12-17(10-24-25)30(27,28)16-4-3-15(22-9-16)8-23-20(26)18-7-14-5-6-21-11-19(14)29-18/h3-7,9-13H,8H2,1-2H3,(H,23,26)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252434
PNG
(US9458172, 1)
Show SMILES Fc1cc(F)cc(c1)S(=O)(=O)c1ccc(CNC(=O)c2cnc3[nH]ncc3c2)nc1
Show InChI InChI=1S/C19H13F2N5O3S/c20-13-4-14(21)6-17(5-13)30(28,29)16-2-1-15(22-10-16)9-24-19(27)12-3-11-8-25-26-18(11)23-7-12/h1-8,10H,9H2,(H,24,27)(H,23,25,26)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252556
PNG
(US9458172, 137)
Show SMILES CS(=O)(=O)c1cccc(c1)S(=O)(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)nc1
Show InChI InChI=1S/C21H18N4O5S2/c1-31(27,28)17-3-2-4-18(11-17)32(29,30)19-7-6-16(23-13-19)12-24-21(26)15-5-8-20-22-9-10-25(20)14-15/h2-11,13-14H,12H2,1H3,(H,24,26)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252498
PNG
(US9458172, 78)
Show SMILES FC(F)(F)c1ccc(cn1)S(=O)(=O)c1ccc(CNC(=O)c2cc3ccncc3s2)nc1
Show InChI InChI=1S/C20H13F3N4O3S2/c21-20(22,23)18-4-3-15(10-26-18)32(29,30)14-2-1-13(25-9-14)8-27-19(28)16-7-12-5-6-24-11-17(12)31-16/h1-7,9-11H,8H2,(H,27,28)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


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More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252463
PNG
(US9458172, 34)
Show SMILES COc1cccc(c1)S(=O)(=O)c1ccc(CNC(=O)c2cnc3[nH]ncc3c2)nc1
Show InChI InChI=1S/C20H17N5O4S/c1-29-16-3-2-4-17(8-16)30(27,28)18-6-5-15(21-12-18)11-23-20(26)14-7-13-10-24-25-19(13)22-9-14/h2-10,12H,11H2,1H3,(H,23,26)(H,22,24,25)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252587
PNG
(US9458172, 168)
Show SMILES FC(F)(F)c1cncc(c1)S(=O)(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)nc1
Show InChI InChI=1S/C20H14F3N5O3S/c21-20(22,23)14-7-17(10-24-8-14)32(30,31)16-3-2-15(26-11-16)9-27-19(29)13-1-4-18-25-5-6-28(18)12-13/h1-8,10-12H,9H2,(H,27,29)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


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More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252590
PNG
(US9458172, 171)
Show SMILES CCCn1cc(cn1)S(=O)(=O)c1ccc(CNC(=O)c2cc3cnccc3[nH]2)nc1
Show InChI InChI=1S/C20H20N6O3S/c1-2-7-26-13-17(12-24-26)30(28,29)16-4-3-15(22-11-16)10-23-20(27)19-8-14-9-21-6-5-18(14)25-19/h3-6,8-9,11-13,25H,2,7,10H2,1H3,(H,23,27)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252588
PNG
(US9458172, 169)
Show SMILES Clc1cncc(c1)S(=O)(=O)c1ccc(CNC(=O)c2cc3ccncc3o2)nc1
Show InChI InChI=1S/C19H13ClN4O4S/c20-13-6-16(9-22-7-13)29(26,27)15-2-1-14(23-10-15)8-24-19(25)17-5-12-3-4-21-11-18(12)28-17/h1-7,9-11H,8H2,(H,24,25)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


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More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252523
PNG
(US9458172, 104)
Show SMILES O=C(NCc1ccc(cn1)S(=O)(=O)C1CCN(CC1)C1COC1)N1Cc2ccncc2C1
Show InChI InChI=1S/C22H27N5O4S/c28-22(27-12-16-3-6-23-9-17(16)13-27)25-10-18-1-2-21(11-24-18)32(29,30)20-4-7-26(8-5-20)19-14-31-15-19/h1-3,6,9,11,19-20H,4-5,7-8,10,12-15H2,(H,25,28)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252540
PNG
(US9458172, 121)
Show SMILES COCC(=O)N1CCC(CC1)S(=O)(=O)c1ccc(CNC(=O)N2Cc3ccncc3C2)nc1
Show InChI InChI=1S/C22H27N5O5S/c1-32-15-21(28)26-8-5-19(6-9-26)33(30,31)20-3-2-18(24-12-20)11-25-22(29)27-13-16-4-7-23-10-17(16)14-27/h2-4,7,10,12,19H,5-6,8-9,11,13-15H2,1H3,(H,25,29)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252545
PNG
(US9458172, 126)
Show SMILES O=C(NCc1ccc(cn1)S(=O)(=O)N1CCN(CC1)C1CCOCC1)N1Cc2ccncc2C1
Show InChI InChI=1S/C23H30N6O4S/c30-23(28-16-18-3-6-24-13-19(18)17-28)26-14-20-1-2-22(15-25-20)34(31,32)29-9-7-27(8-10-29)21-4-11-33-12-5-21/h1-3,6,13,15,21H,4-5,7-12,14,16-17H2,(H,26,30)
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The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252521
PNG
(US9458172, 102)
Show SMILES CC(C)CN1CCC(CC1)S(=O)c1ccc(CNC(=O)c2cc3ccncc3o2)nc1
Show InChI InChI=1S/C23H28N4O3S/c1-16(2)15-27-9-6-19(7-10-27)31(29)20-4-3-18(25-13-20)12-26-23(28)21-11-17-5-8-24-14-22(17)30-21/h3-5,8,11,13-14,16,19H,6-7,9-10,12,15H2,1-2H3,(H,26,28)
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The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


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More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252502
PNG
(US9458172, 82)
Show SMILES FC(F)(F)c1ccc(cn1)S(=O)(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)nc1
Show InChI InChI=1S/C20H14F3N5O3S/c21-20(22,23)17-5-4-16(11-26-17)32(30,31)15-3-2-14(25-10-15)9-27-19(29)13-1-6-18-24-7-8-28(18)12-13/h1-8,10-12H,9H2,(H,27,29)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


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More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252547
PNG
(US9458172, 128)
Show SMILES O=C(NCc1ccc(cn1)S(=O)(=O)C1CCN(CC1)C1CCOC1)c1cc2ccncc2o1
Show InChI InChI=1S/C23H26N4O5S/c28-23(21-11-16-3-7-24-14-22(16)32-21)26-12-17-1-2-20(13-25-17)33(29,30)19-4-8-27(9-5-19)18-6-10-31-15-18/h1-3,7,11,13-14,18-19H,4-6,8-10,12,15H2,(H,26,28)
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The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


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More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252574
PNG
(US9458172, 155)
Show SMILES O=C(NCc1ccc(cn1)S(=O)(=O)c1cccc(c1)C#N)c1ccc2nccn2c1
Show InChI InChI=1S/C21H15N5O3S/c22-11-15-2-1-3-18(10-15)30(28,29)19-6-5-17(24-13-19)12-25-21(27)16-4-7-20-23-8-9-26(20)14-16/h1-10,13-14H,12H2,(H,25,27)
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The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


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More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252567
PNG
(US9458172, 148)
Show SMILES O=C(NCc1ccc(cn1)S(=O)(=O)N1CCC(CC1)N1CCCC1)N1Cc2ccncc2C1
Show InChI InChI=1S/C23H30N6O3S/c30-23(28-16-18-5-8-24-13-19(18)17-28)26-14-20-3-4-22(15-25-20)33(31,32)29-11-6-21(7-12-29)27-9-1-2-10-27/h3-5,8,13,15,21H,1-2,6-7,9-12,14,16-17H2,(H,26,30)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252537
PNG
(US9458172, 118)
Show SMILES FC(F)(F)CN1CCC(CC1)S(=O)c1ccc(CNC(=O)[N]2=Cc3ccncc3O2)nc1
Show InChI InChI=1S/C20H21F3N5O3S/c21-20(22,23)13-27-7-4-16(5-8-27)32(30)17-2-1-15(25-10-17)9-26-19(29)28-12-14-3-6-24-11-18(14)31-28/h1-3,6,10-12,16H,4-5,7-9,13H2,(H,26,29)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252481
PNG
(US9458172, 53)
Show SMILES O=C(NCc1ccc(cn1)S(=O)(=O)C1CCOCC1)c1cc2ccncc2s1
Show InChI InChI=1S/C19H19N3O4S2/c23-19(17-9-13-3-6-20-12-18(13)27-17)22-10-14-1-2-16(11-21-14)28(24,25)15-4-7-26-8-5-15/h1-3,6,9,11-12,15H,4-5,7-8,10H2,(H,22,23)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252600
PNG
(US9458172, 184)
Show SMILES O=C(NCc1ccc(cn1)S(=O)(=O)c1ccccc1)c1ccc2nccn2c1
Show InChI InChI=1S/C20H16N4O3S/c25-20(15-6-9-19-21-10-11-24(19)14-15)23-12-16-7-8-18(13-22-16)28(26,27)17-4-2-1-3-5-17/h1-11,13-14H,12H2,(H,23,25)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252569
PNG
(US9458172, 150)
Show SMILES Nc1ccc(cn1)S(=O)(=O)c1ccc(CNC(=O)N2Cc3ccncc3C2)nc1
Show InChI InChI=1S/C19H18N6O3S/c20-18-4-3-17(10-23-18)29(27,28)16-2-1-15(22-9-16)8-24-19(26)25-11-13-5-6-21-7-14(13)12-25/h1-7,9-10H,8,11-12H2,(H2,20,23)(H,24,26)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252465
PNG
(US9458172, 36)
Show SMILES Cn1cc(cn1)S(=O)(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)nc1
Show InChI InChI=1S/C18H16N6O3S/c1-23-12-16(10-22-23)28(26,27)15-4-3-14(20-9-15)8-21-18(25)13-2-5-17-19-6-7-24(17)11-13/h2-7,9-12H,8H2,1H3,(H,21,25)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252541
PNG
(US9458172, 122)
Show SMILES COCC(=O)N1CCC(CC1)S(=O)(=O)c1ccc(CNC(=O)c2cc3ccncc3o2)nc1
Show InChI InChI=1S/C22H24N4O6S/c1-31-14-21(27)26-8-5-17(6-9-26)33(29,30)18-3-2-16(24-12-18)11-25-22(28)19-10-15-4-7-23-13-20(15)32-19/h2-4,7,10,12-13,17H,5-6,8-9,11,14H2,1H3,(H,25,28)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252437
PNG
(US9458172, 6)
Show SMILES O=C(NCc1ncc(cn1)S(=O)(=O)c1ccccc1)c1cnc2[nH]ncc2c1
Show InChI InChI=1S/C18H14N6O3S/c25-18(13-6-12-8-23-24-17(12)21-7-13)22-11-16-19-9-15(10-20-16)28(26,27)14-4-2-1-3-5-14/h1-10H,11H2,(H,22,25)(H,21,23,24)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252562
PNG
(US9458172, 143)
Show SMILES FC(F)(F)CN1CCC(CC1)S(=O)(=O)c1ccc(CNC(=O)N2Cc3ccncc3C2)nc1
Show InChI InChI=1S/C21H24F3N5O3S/c22-21(23,24)14-28-7-4-18(5-8-28)33(31,32)19-2-1-17(26-11-19)10-27-20(30)29-12-15-3-6-25-9-16(15)13-29/h1-3,6,9,11,18H,4-5,7-8,10,12-14H2,(H,27,30)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50060765
PNG
(CHEMBL3394739 | US9458172, 175)
Show SMILES CC(C)n1cc(cn1)S(=O)(=O)c1ccc(CNC(=O)c2cc3cnccc3[nH]2)nc1
Show InChI InChI=1S/C20H20N6O3S/c1-13(2)26-12-17(11-24-26)30(28,29)16-4-3-15(22-10-16)9-23-20(27)19-7-14-8-21-6-5-18(14)25-19/h3-8,10-13,25H,9H2,1-2H3,(H,23,27)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252602
PNG
(US9458172, 186)
Show SMILES O=C(NCc1ccc(cn1)S(=O)(=O)c1ccccc1)c1cc2ccncc2s1
Show InChI InChI=1S/C20H15N3O3S2/c24-20(18-10-14-8-9-21-13-19(14)27-18)23-11-15-6-7-17(12-22-15)28(25,26)16-4-2-1-3-5-16/h1-10,12-13H,11H2,(H,23,24)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252469
PNG
(US9458172, 40)
Show SMILES Cn1cc(cn1)S(=O)(=O)c1ccc(CNC(=O)c2cc3ccncc3s2)nc1
Show InChI InChI=1S/C18H15N5O3S2/c1-23-11-15(9-22-23)28(25,26)14-3-2-13(20-8-14)7-21-18(24)16-6-12-4-5-19-10-17(12)27-16/h2-6,8-11H,7H2,1H3,(H,21,24)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252525
PNG
(US9458172, 106)
Show SMILES CCS(=O)(=O)c1cccc(c1)S(=O)(=O)c1ccc(CNC(=O)c2cnc3[nH]ncc3c2)nc1
Show InChI InChI=1S/C21H19N5O5S2/c1-2-32(28,29)17-4-3-5-18(9-17)33(30,31)19-7-6-16(22-13-19)12-24-21(27)15-8-14-11-25-26-20(14)23-10-15/h3-11,13H,2,12H2,1H3,(H,24,27)(H,23,25,26)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252583
PNG
(US9458172, 164)
Show SMILES Clc1cncc(c1)S(=O)(=O)c1ccc(CNC(=O)c2cnc3[nH]ncc3c2)nc1
Show InChI InChI=1S/C18H13ClN6O3S/c19-13-4-16(9-20-7-13)29(27,28)15-2-1-14(21-10-15)8-23-18(26)12-3-11-6-24-25-17(11)22-5-12/h1-7,9-10H,8H2,(H,23,26)(H,22,24,25)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252438
PNG
(US9458172, 7)
Show SMILES O=C(NCc1ncc(cn1)S(=O)(=O)c1ccccc1)c1cc2cnccc2[nH]1
Show InChI InChI=1S/C19H15N5O3S/c25-19(17-8-13-9-20-7-6-16(13)24-17)23-12-18-21-10-15(11-22-18)28(26,27)14-4-2-1-3-5-14/h1-11,24H,12H2,(H,23,25)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252577
PNG
(US9458172, 158)
Show SMILES O=C(NCc1ccc(cn1)S(=O)(=O)c1cccc(c1)C#N)N1Cc2ccncc2C1
Show InChI InChI=1S/C21H17N5O3S/c22-9-15-2-1-3-19(8-15)30(28,29)20-5-4-18(24-12-20)11-25-21(27)26-13-16-6-7-23-10-17(16)14-26/h1-8,10,12H,11,13-14H2,(H,25,27)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252479
PNG
(US9458172, 51)
Show SMILES O=C(NCc1ccc(cn1)S(=O)(=O)C1CCOCC1)c1cc2ccncc2o1
Show InChI InChI=1S/C19H19N3O5S/c23-19(17-9-13-3-6-20-12-18(13)27-17)22-10-14-1-2-16(11-21-14)28(24,25)15-4-7-26-8-5-15/h1-3,6,9,11-12,15H,4-5,7-8,10H2,(H,22,23)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252592
PNG
(US9458172, 173)
Show SMILES FC(F)(F)CN1CCC(CC1)S(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)nc1
Show InChI InChI=1S/C21H22F3N5O2S/c22-21(23,24)14-28-8-5-17(6-9-28)32(31)18-3-2-16(26-12-18)11-27-20(30)15-1-4-19-25-7-10-29(19)13-15/h1-4,7,10,12-13,17H,5-6,8-9,11,14H2,(H,27,30)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252455
PNG
(US9458172, 26)
Show SMILES O=C(NCc1ccc(cn1)S(=O)(=O)C1CCNCC1)c1cc2ccncc2o1
Show InChI InChI=1S/C19H20N4O4S/c24-19(17-9-13-3-6-21-12-18(13)27-17)23-10-14-1-2-16(11-22-14)28(25,26)15-4-7-20-8-5-15/h1-3,6,9,11-12,15,20H,4-5,7-8,10H2,(H,23,24)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252560
PNG
(US9458172, 141)
Show SMILES O=C(NCc1ccc(cn1)S(=O)(=O)N1CCN(CC1)C1COC1)c1cc2ccncc2o1
Show InChI InChI=1S/C21H23N5O5S/c27-21(19-9-15-3-4-22-12-20(15)31-19)24-10-16-1-2-18(11-23-16)32(28,29)26-7-5-25(6-8-26)17-13-30-14-17/h1-4,9,11-12,17H,5-8,10,13-14H2,(H,24,27)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252593
PNG
(US9458172, 174)
Show SMILES O=C(NCc1ccc(cn1)S(=O)(=O)c1cncc(c1)C#N)c1cc2ccncc2o1
Show InChI InChI=1S/C20H13N5O4S/c21-7-13-5-17(10-23-8-13)30(27,28)16-2-1-15(24-11-16)9-25-20(26)18-6-14-3-4-22-12-19(14)29-18/h1-6,8,10-12H,9H2,(H,25,26)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252584
PNG
(US9458172, 165)
Show SMILES FC(F)(F)c1cncc(c1)S(=O)(=O)c1ccc(CNC(=O)c2cnc3[nH]ncc3c2)nc1
Show InChI InChI=1S/C19H13F3N6O3S/c20-19(21,22)13-4-16(9-23-7-13)32(30,31)15-2-1-14(24-10-15)8-26-18(29)12-3-11-6-27-28-17(11)25-5-12/h1-7,9-10H,8H2,(H,26,29)(H,25,27,28)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252561
PNG
(US9458172, 142)
Show SMILES O=C(NCc1ccc(cn1)S(=O)(=O)N1CCN(CC1)C1COC1)N1Cc2ccncc2C1
Show InChI InChI=1S/C21H26N6O4S/c28-21(26-12-16-3-4-22-9-17(16)13-26)24-10-18-1-2-20(11-23-18)32(29,30)27-7-5-25(6-8-27)19-14-31-15-19/h1-4,9,11,19H,5-8,10,12-15H2,(H,24,28)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252585
PNG
(US9458172, 166)
Show SMILES FC(F)(F)CN1CCC(CC1)S(=O)(=O)c1ccc(CNC(=O)c2cc3cnccc3[nH]2)nc1
Show InChI InChI=1S/C21H22F3N5O3S/c22-21(23,24)13-29-7-4-16(5-8-29)33(31,32)17-2-1-15(26-12-17)11-27-20(30)19-9-14-10-25-6-3-18(14)28-19/h1-3,6,9-10,12,16,28H,4-5,7-8,11,13H2,(H,27,30)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252571
PNG
(US9458172, 152)
Show SMILES FC(F)(F)CN1CCC(CC1)S(=O)(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)nc1
Show InChI InChI=1S/C21H22F3N5O3S/c22-21(23,24)14-28-8-5-17(6-9-28)33(31,32)18-3-2-16(26-12-18)11-27-20(30)15-1-4-19-25-7-10-29(19)13-15/h1-4,7,10,12-13,17H,5-6,8-9,11,14H2,(H,27,30)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252471
PNG
(US9458172, 42)
Show SMILES O=C(NCc1ccc(cn1)S(=O)(=O)C1CCN(CC1)C1CCOCC1)c1cc2cnccc2[nH]1
Show InChI InChI=1S/C24H29N5O4S/c30-24(23-13-17-14-25-8-3-22(17)28-23)27-15-18-1-2-21(16-26-18)34(31,32)20-4-9-29(10-5-20)19-6-11-33-12-7-19/h1-3,8,13-14,16,19-20,28H,4-7,9-12,15H2,(H,27,30)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252591
PNG
(US9458172, 172)
Show SMILES CC(C)CN1CCC(CC1)S(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)nc1
Show InChI InChI=1S/C23H29N5O2S/c1-17(2)15-27-10-7-20(8-11-27)31(30)21-5-4-19(25-14-21)13-26-23(29)18-3-6-22-24-9-12-28(22)16-18/h3-6,9,12,14,16-17,20H,7-8,10-11,13,15H2,1-2H3,(H,26,29)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252580
PNG
(US9458172, 161)
Show SMILES O=C(NCc1ccc(cn1)S(=O)(=O)C1CCN(CC1)C1CCOCC1)c1ccc2nccn2c1
Show InChI InChI=1S/C24H29N5O4S/c30-24(18-1-4-23-25-9-12-29(23)17-18)27-15-19-2-3-22(16-26-19)34(31,32)21-5-10-28(11-6-21)20-7-13-33-14-8-20/h1-4,9,12,16-17,20-21H,5-8,10-11,13-15H2,(H,27,30)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252576
PNG
(US9458172, 157)
Show SMILES O=C(NCc1ccc(cn1)S(=O)(=O)c1cccc(c1)N1CCOCC1)c1cnc2[nH]ncc2c1
Show InChI InChI=1S/C23H22N6O4S/c30-23(17-10-16-13-27-28-22(16)25-12-17)26-14-18-4-5-21(15-24-18)34(31,32)20-3-1-2-19(11-20)29-6-8-33-9-7-29/h1-5,10-13,15H,6-9,14H2,(H,26,30)(H,25,27,28)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252454
PNG
(US9458172, 25 | US9458172, 28 | US9458172, 29)
Show SMILES Fc1cc(F)cc(c1)S(=O)c1ccc(CNC(=O)c2cc3ccncc3o2)nc1
Show InChI InChI=1S/C20H13F2N3O3S/c21-13-6-14(22)8-17(7-13)29(27)16-2-1-15(24-10-16)9-25-20(26)18-5-12-3-4-23-11-19(12)28-18/h1-8,10-11H,9H2,(H,25,26)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252439
PNG
(US9458172, 8)
Show SMILES O=C(NCc1ncc(cn1)S(=O)(=O)c1ccccc1)c1ccc2nccn2c1
Show InChI InChI=1S/C19H15N5O3S/c25-19(14-6-7-18-20-8-9-24(18)13-14)23-12-17-21-10-16(11-22-17)28(26,27)15-4-2-1-3-5-15/h1-11,13H,12H2,(H,23,25)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252506
PNG
(US9458172, 86)
Show SMILES Nc1ncc2CN(Cc2n1)C(=O)NCc1ccc(cn1)S(=O)(=O)c1cc(F)cc(F)c1
Show InChI InChI=1S/C19H16F2N6O3S/c20-12-3-13(21)5-16(4-12)31(29,30)15-2-1-14(23-8-15)7-25-19(28)27-9-11-6-24-18(22)26-17(11)10-27/h1-6,8H,7,9-10H2,(H,25,28)(H2,22,24,26)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


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More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252445
PNG
(US9458172, 15)
Show SMILES Fc1cc(F)cc(c1)S(=O)c1ccc(CNC(=O)c2cnc3[nH]ncc3c2)nc1
Show InChI InChI=1S/C19H13F2N5O2S/c20-13-4-14(21)6-17(5-13)29(28)16-2-1-15(22-10-16)9-24-19(27)12-3-11-8-25-26-18(11)23-7-12/h1-8,10H,9H2,(H,24,27)(H,23,25,26)
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US Patent


Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252444
PNG
(US9458172, 14 | US9458172, 55 | US9458172, 58)
Show SMILES Fc1cc(F)cc(c1)S(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)nc1
Show InChI InChI=1S/C20H14F2N4O2S/c21-14-7-15(22)9-18(8-14)29(28)17-3-2-16(24-11-17)10-25-20(27)13-1-4-19-23-5-6-26(19)12-13/h1-9,11-12H,10H2,(H,25,27)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252603
PNG
(US9458172, 187)
Show SMILES O=C(NCc1ncc(cn1)S(=O)(=O)c1ccccc1)c1cc2ccncc2s1
Show InChI InChI=1S/C19H14N4O3S2/c24-19(16-8-13-6-7-20-11-17(13)27-16)23-12-18-21-9-15(10-22-18)28(25,26)14-4-2-1-3-5-14/h1-11H,12H2,(H,23,24)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252575
PNG
(US9458172, 156)
Show SMILES O=C(NCc1ccc(cn1)S(=O)(=O)c1cccc(c1)C#N)c1cnc2[nH]ncc2c1
Show InChI InChI=1S/C20H14N6O3S/c21-8-13-2-1-3-17(6-13)30(28,29)18-5-4-16(22-12-18)11-24-20(27)15-7-14-10-25-26-19(14)23-9-15/h1-7,9-10,12H,11H2,(H,24,27)(H,23,25,26)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252598
PNG
(US9458172, 180)
Show SMILES O=C(NCc1ccc(cn1)S(=O)(=O)N1CCCCC1)N1Cc2cn[nH]c2C1
Show InChI InChI=1S/C17H22N6O3S/c24-17(22-11-13-8-20-21-16(13)12-22)19-9-14-4-5-15(10-18-14)27(25,26)23-6-2-1-3-7-23/h4-5,8,10H,1-3,6-7,9,11-12H2,(H,19,24)(H,20,21)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252456
PNG
(US9458172, 27)
Show SMILES O=C(NCc1ccc(cn1)S(=O)(=O)C1CCNCC1)c1ccc2nccn2c1
Show InChI InChI=1S/C19H21N5O3S/c25-19(14-1-4-18-21-9-10-24(18)13-14)23-11-15-2-3-17(12-22-15)28(26,27)16-5-7-20-8-6-16/h1-4,9-10,12-13,16,20H,5-8,11H2,(H,23,25)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252568
PNG
(US9458172, 149)
Show SMILES O=C(NCc1ccc(cn1)S(=O)(=O)N1CCC(CC1)N1CCCC1)c1cnc2[nH]ncc2c1
Show InChI InChI=1S/C22H27N7O3S/c30-22(17-11-16-13-26-27-21(16)24-12-17)25-14-18-3-4-20(15-23-18)33(31,32)29-9-5-19(6-10-29)28-7-1-2-8-28/h3-4,11-13,15,19H,1-2,5-10,14H2,(H,25,30)(H,24,26,27)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252535
PNG
(US9458172, 116 | US9458172, 159 | US9458172, 160)
Show SMILES Fc1cc(F)cc(c1)S(=O)c1ccc(CNC(=O)N2Cc3ccncc3C2)nc1
Show InChI InChI=1S/C20H16F2N4O2S/c21-15-5-16(22)7-19(6-15)29(28)18-2-1-17(24-10-18)9-25-20(27)26-11-13-3-4-23-8-14(13)12-26/h1-8,10H,9,11-12H2,(H,25,27)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252487
PNG
(US9458172, 60)
Show SMILES O=C(NCc1ccc(cn1)S(=O)(=O)C1CCOCC1)c1ccc2nccn2c1
Show InChI InChI=1S/C19H20N4O4S/c24-19(14-1-4-18-20-7-8-23(18)13-14)22-11-15-2-3-17(12-21-15)28(25,26)16-5-9-27-10-6-16/h1-4,7-8,12-13,16H,5-6,9-11H2,(H,22,24)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252526
PNG
(US9458172, 107)
Show SMILES FC(F)(F)c1ccc(cn1)S(=O)(=O)c1ccc(CNC(=O)c2cnc3[nH]ncc3c2)nc1
Show InChI InChI=1S/C19H13F3N6O3S/c20-19(21,22)16-4-3-15(10-24-16)32(30,31)14-2-1-13(23-9-14)8-26-18(29)12-5-11-7-27-28-17(11)25-6-12/h1-7,9-10H,8H2,(H,26,29)(H,25,27,28)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252597
PNG
(US9458172, 179)
Show SMILES Cn1ncc2CN(Cc12)C(=O)NCc1ccc(cn1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C19H19N5O3S/c1-23-18-13-24(12-14(18)9-22-23)19(25)21-10-15-7-8-17(11-20-15)28(26,27)16-5-3-2-4-6-16/h2-9,11H,10,12-13H2,1H3,(H,21,25)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252572
PNG
(US9458172, 153)
Show SMILES FC(F)(F)CN1CCC(CC1)S(=O)(=O)c1ccc(CNC(=O)c2cnc3[nH]ncc3c2)nc1
Show InChI InChI=1S/C20H21F3N6O3S/c21-20(22,23)12-29-5-3-16(4-6-29)33(31,32)17-2-1-15(24-11-17)10-26-19(30)14-7-13-9-27-28-18(13)25-8-14/h1-2,7-9,11,16H,3-6,10,12H2,(H,26,30)(H,25,27,28)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252581
PNG
(US9458172, 162)
Show SMILES O=C(NCc1ccc(cn1)S(=O)(=O)C1CCN(CC1)C1CCOCC1)c1cnc2[nH]ncc2c1
Show InChI InChI=1S/C23H28N6O4S/c30-23(17-11-16-13-27-28-22(16)25-12-17)26-14-18-1-2-21(15-24-18)34(31,32)20-3-7-29(8-4-20)19-5-9-33-10-6-19/h1-2,11-13,15,19-20H,3-10,14H2,(H,26,30)(H,25,27,28)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM252596
PNG
(US9458172, 178)
Show SMILES O=C(NCC1CC=C(C=N1)S(=O)(=O)c1ccccc1)N1Cc2cn[nH]c2C1
Show InChI InChI=1S/C18H19N5O3S/c24-18(23-11-13-8-21-22-17(13)12-23)20-9-14-6-7-16(10-19-14)27(25,26)15-4-2-1-3-5-15/h1-5,7-8,10,14H,6,9,11-12H2,(H,20,24)(H,21,22)
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Assay Description
The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%