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Patent code US9458201

Compile Data Set for Download or QSAR
Found 162 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135752
PNG
(US8846601, 137 | US9458201, 137)
Show SMILES NCC[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)C1CCCCC1
Show InChI InChI=1S/C53H79N17O9/c54-23-22-39-48(76)68-40(27-31-13-3-1-4-14-31)49(77)66-38(21-12-26-62-53(58)59)47(75)69-41(28-33-30-63-35-18-8-7-17-34(33)35)50(78)64-36(44(55)72)19-9-10-24-60-43(71)29-42(51(79)67-39)70-46(74)37(20-11-25-61-52(56)57)65-45(73)32-15-5-2-6-16-32/h1,3-4,7-8,13-14,17-18,30,32,36-42,63H,2,5-6,9-12,15-16,19-29,54H2,(H2,55,72)(H,60,71)(H,64,78)(H,65,73)(H,66,77)(H,67,79)(H,68,76)(H,69,75)(H,70,74)(H4,56,57,61)(H4,58,59,62)/t36-,37-,38-,39-,40+,41-,42-/m0/s1
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US Patent
0.400n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135736
PNG
(US8846601, 121 | US9458201, 121)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCN)NC1=O)C(N)=O
Show InChI InChI=1S/C48H71N17O9/c1-27(66)59-32(16-9-21-56-47(51)52)41(69)60-33-15-7-8-20-55-39(67)25-36(40(50)68)63-46(74)38(24-29-26-58-31-14-6-5-13-30(29)31)65-43(71)34(17-10-22-57-48(53)54)61-45(73)37(23-28-11-3-2-4-12-28)64-44(72)35(18-19-49)62-42(33)70/h2-6,11-14,26,32-38,58H,7-10,15-25,49H2,1H3,(H2,50,68)(H,55,67)(H,59,66)(H,60,69)(H,61,73)(H,62,70)(H,63,74)(H,64,72)(H,65,71)(H4,51,52,56)(H4,53,54,57)/t32-,33-,34-,35-,36-,37+,38-/m0/s1
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0.400n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135690
PNG
(US8846601, 75 | US9458201, 75)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O
Show InChI InChI=1S/C50H70N18O9/c1-28(69)62-35(14-8-20-58-49(52)53)43(72)64-36-15-7-19-57-41(70)18-17-34(42(51)71)63-47(76)39(23-30-25-60-33-13-6-5-12-32(30)33)67-44(73)37(16-9-21-59-50(54)55)65-46(75)38(22-29-10-3-2-4-11-29)66-48(77)40(68-45(36)74)24-31-26-56-27-61-31/h2-6,10-13,25-27,34-40,60H,7-9,14-24H2,1H3,(H2,51,71)(H,56,61)(H,57,70)(H,62,69)(H,63,76)(H,64,72)(H,65,75)(H,66,77)(H,67,73)(H,68,74)(H4,52,53,58)(H4,54,55,59)/t34-,35-,36-,37-,38+,39-,40-/m0/s1
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0.600n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135630
PNG
(US8846601, 15 | US9458201, 15)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@H](CN2C1=O)OCc1ccccc1)C(N)=O
Show InChI InChI=1S/C56H76N16O10/c1-33(73)66-41(21-12-24-63-55(58)59)49(76)71-45-29-47(74)62-23-11-10-20-40(48(57)75)67-52(79)44(27-36-30-65-39-19-9-8-18-38(36)39)69-50(77)42(22-13-25-64-56(60)61)68-51(78)43(26-34-14-4-2-5-15-34)70-53(80)46-28-37(31-72(46)54(45)81)82-32-35-16-6-3-7-17-35/h2-9,14-19,30,37,40-46,65H,10-13,20-29,31-32H2,1H3,(H2,57,75)(H,62,74)(H,66,73)(H,67,79)(H,68,78)(H,69,77)(H,70,80)(H,71,76)(H4,58,59,63)(H4,60,61,64)/t37-,40+,41+,42+,43-,44+,45+,46+/m1/s1
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0.700n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135717
PNG
(US8846601, 102 | US9458201, 102)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC1=O)C(N)=O
Show InChI InChI=1S/C50H75N19O9/c1-28(70)63-34(16-8-22-59-48(52)53)42(73)67-37-19-20-40(71)58-21-7-15-33(41(51)72)64-47(78)39(26-30-27-62-32-14-6-5-13-31(30)32)69-44(75)36(18-10-24-61-50(56)57)66-46(77)38(25-29-11-3-2-4-12-29)68-43(74)35(65-45(37)76)17-9-23-60-49(54)55/h2-6,11-14,27,33-39,62H,7-10,15-26H2,1H3,(H2,51,72)(H,58,71)(H,63,70)(H,64,78)(H,65,76)(H,66,77)(H,67,73)(H,68,74)(H,69,75)(H4,52,53,59)(H4,54,55,60)(H4,56,57,61)/t33-,34-,35-,36-,37-,38+,39-/m0/s1
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0.700n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135753
PNG
(US8846601, 138 | US9458201, 138)
Show SMILES NCC[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CC1CCCC1
Show InChI InChI=1S/C53H79N17O9/c54-22-21-39-48(76)68-40(26-31-12-2-1-3-13-31)49(77)66-38(20-11-25-62-53(58)59)47(75)69-41(28-33-30-63-35-17-7-6-16-34(33)35)50(78)65-36(45(55)73)18-8-9-23-60-43(71)29-42(51(79)67-39)70-46(74)37(19-10-24-61-52(56)57)64-44(72)27-32-14-4-5-15-32/h1-3,6-7,12-13,16-17,30,32,36-42,63H,4-5,8-11,14-15,18-29,54H2,(H2,55,73)(H,60,71)(H,64,72)(H,65,78)(H,66,77)(H,67,79)(H,68,76)(H,69,75)(H,70,74)(H4,56,57,61)(H4,58,59,62)/t36-,37-,38-,39-,40+,41-,42-/m0/s1
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0.800n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135725
PNG
(US8846601, 110 | US9458201, 110)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(=O)NC1CC1
Show InChI InChI=1S/C53H74N18O9/c1-30(72)64-37(14-8-22-60-52(54)55)46(75)68-40-19-20-44(73)59-21-7-15-38(45(74)65-33-17-18-33)66-50(79)42(25-32-27-62-36-13-6-5-12-35(32)36)70-47(76)39(16-9-23-61-53(56)57)67-49(78)41(24-31-10-3-2-4-11-31)69-51(80)43(71-48(40)77)26-34-28-58-29-63-34/h2-6,10-13,27-29,33,37-43,62H,7-9,14-26H2,1H3,(H,58,63)(H,59,73)(H,64,72)(H,65,74)(H,66,79)(H,67,78)(H,68,75)(H,69,80)(H,70,76)(H,71,77)(H4,54,55,60)(H4,56,57,61)/t37-,38-,39-,40-,41+,42-,43-/m0/s1
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1n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135679
PNG
(US8846601, 64 | US9458201, 64)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O
Show InChI InChI=1S/C50H70N18O9/c1-28(69)62-35(15-8-20-58-49(52)53)43(72)65-37-17-18-41(70)57-19-7-14-34(42(51)71)63-47(76)39(23-30-25-60-33-13-6-5-12-32(30)33)67-44(73)36(16-9-21-59-50(54)55)64-46(75)38(22-29-10-3-2-4-11-29)66-48(77)40(68-45(37)74)24-31-26-56-27-61-31/h2-6,10-13,25-27,34-40,60H,7-9,14-24H2,1H3,(H2,51,71)(H,56,61)(H,57,70)(H,62,69)(H,63,76)(H,64,75)(H,65,72)(H,66,77)(H,67,73)(H,68,74)(H4,52,53,58)(H4,54,55,59)/t34-,35-,36-,37-,38+,39-,40-/m0/s1
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Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM253650
PNG
(US9458201, 96)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O
Show InChI InChI=1S/C50H70N18O9/c1-28(69)62-34(16-9-19-58-49(52)53)43(72)63-35-15-7-8-18-57-41(70)24-37(42(51)71)65-47(76)39(22-30-25-60-33-14-6-5-13-32(30)33)67-45(74)36(17-10-20-59-50(54)55)64-46(75)38(21-29-11-3-2-4-12-29)66-48(77)40(68-44(35)73)23-31-26-56-27-61-31/h2-6,11-14,25-27,34-40,60H,7-10,15-24H2,1H3,(H2,51,71)(H,56,61)(H,57,70)(H,62,69)(H,63,72)(H,64,75)(H,65,76)(H,66,77)(H,67,74)(H,68,73)(H4,52,53,58)(H4,54,55,59)/t34-,35-,36-,37-,38+,39-,40-/m0/s1
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Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135629
PNG
(US8846601, 14 | US9458201, 14)
Show SMILES C[C@@H](OCc1ccccc1)[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O
Show InChI InChI=1S/C55H76N16O10/c1-32(81-31-35-17-7-4-8-18-35)46-53(80)70-42(27-34-15-5-3-6-16-34)50(77)67-41(23-14-26-63-55(59)60)49(76)68-43(28-36-30-64-38-20-10-9-19-37(36)38)51(78)66-39(47(56)74)21-11-12-24-61-45(73)29-44(52(79)71-46)69-48(75)40(65-33(2)72)22-13-25-62-54(57)58/h3-10,15-20,30,32,39-44,46,64H,11-14,21-29,31H2,1-2H3,(H2,56,74)(H,61,73)(H,65,72)(H,66,78)(H,67,77)(H,68,76)(H,69,75)(H,70,80)(H,71,79)(H4,57,58,62)(H4,59,60,63)/t32-,39+,40+,41+,42-,43+,44+,46+/m1/s1
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1n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135741
PNG
(US8846601, 126 | US9458201, 126)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCC(=O)NCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O
Show InChI InChI=1S/C50H70N18O9/c1-28(69)62-35(15-8-19-58-49(52)53)43(72)64-36-14-7-17-41(70)57-21-18-34(42(51)71)63-47(76)39(23-30-25-60-33-13-6-5-12-32(30)33)67-45(74)37(16-9-20-59-50(54)55)65-46(75)38(22-29-10-3-2-4-11-29)66-48(77)40(68-44(36)73)24-31-26-56-27-61-31/h2-6,10-13,25-27,34-40,60H,7-9,14-24H2,1H3,(H2,51,71)(H,56,61)(H,57,70)(H,62,69)(H,63,76)(H,64,72)(H,65,75)(H,66,77)(H,67,74)(H,68,73)(H4,52,53,58)(H4,54,55,59)/t34-,35-,36-,37-,38+,39-,40-/m0/s1
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1n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135754
PNG
(US8846601, 139 | US9458201, 139)
Show SMILES NCC[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CC1CCCCC1
Show InChI InChI=1S/C54H81N17O9/c55-23-22-40-49(77)69-41(27-32-13-3-1-4-14-32)50(78)67-39(21-12-26-63-54(59)60)48(76)70-42(29-34-31-64-36-18-8-7-17-35(34)36)51(79)66-37(46(56)74)19-9-10-24-61-44(72)30-43(52(80)68-40)71-47(75)38(20-11-25-62-53(57)58)65-45(73)28-33-15-5-2-6-16-33/h1,3-4,7-8,13-14,17-18,31,33,37-43,64H,2,5-6,9-12,15-16,19-30,55H2,(H2,56,74)(H,61,72)(H,65,73)(H,66,79)(H,67,78)(H,68,80)(H,69,77)(H,70,76)(H,71,75)(H4,57,58,62)(H4,59,60,63)/t37-,38-,39-,40-,41+,42-,43-/m0/s1
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1n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135687
PNG
(US8846601, 72 | US9458201, 72)
Show SMILES CC(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](Cc3ccccc3)CN2C1=O)C(N)=O
Show InChI InChI=1S/C56H76N16O9/c1-33(73)66-41(21-12-24-63-55(58)59)49(76)71-45-30-47(74)62-23-11-10-20-40(48(57)75)67-52(79)44(29-37-31-65-39-19-9-8-18-38(37)39)69-50(77)42(22-13-25-64-56(60)61)68-51(78)43(27-35-16-6-3-7-17-35)70-53(80)46-28-36(32-72(46)54(45)81)26-34-14-4-2-5-15-34/h2-9,14-19,31,36,40-46,65H,10-13,20-30,32H2,1H3,(H2,57,75)(H,62,74)(H,66,73)(H,67,79)(H,68,78)(H,69,77)(H,70,80)(H,71,76)(H4,58,59,63)(H4,60,61,64)/t36-,40+,41-,42+,43-,44+,45+,46+/m1/s1
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Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


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More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135755
PNG
(US8846601, 140 | US9458201, 140)
Show SMILES NCC[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)Cc1ccccc1
Show InChI InChI=1S/C54H75N17O9/c55-23-22-40-49(77)69-41(27-32-13-3-1-4-14-32)50(78)67-39(21-12-26-63-54(59)60)48(76)70-42(29-34-31-64-36-18-8-7-17-35(34)36)51(79)66-37(46(56)74)19-9-10-24-61-44(72)30-43(52(80)68-40)71-47(75)38(20-11-25-62-53(57)58)65-45(73)28-33-15-5-2-6-16-33/h1-8,13-18,31,37-43,64H,9-12,19-30,55H2,(H2,56,74)(H,61,72)(H,65,73)(H,66,79)(H,67,78)(H,68,80)(H,69,77)(H,70,76)(H,71,75)(H4,57,58,62)(H4,59,60,63)/t37-,38-,39-,40-,41+,42-,43-/m0/s1
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Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


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More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135743
PNG
(US8846601, 128 | US9458201, 128)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCNC(=O)CCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O
Show InChI InChI=1S/C50H70N18O9/c1-28(69)62-35(15-8-19-58-49(52)53)43(72)65-37-18-21-57-41(70)17-7-14-34(42(51)71)63-47(76)39(23-30-25-60-33-13-6-5-12-32(30)33)67-44(73)36(16-9-20-59-50(54)55)64-46(75)38(22-29-10-3-2-4-11-29)66-48(77)40(68-45(37)74)24-31-26-56-27-61-31/h2-6,10-13,25-27,34-40,60H,7-9,14-24H2,1H3,(H2,51,71)(H,56,61)(H,57,70)(H,62,69)(H,63,76)(H,64,75)(H,65,72)(H,66,77)(H,67,73)(H,68,74)(H4,52,53,58)(H4,54,55,59)/t34-,35-,36-,37-,38+,39-,40-/m0/s1
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Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135742
PNG
(US8846601, 127 | US9458201, 127)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCC(=O)NCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCN)NC1=O)C(N)=O
Show InChI InChI=1S/C48H71N17O9/c1-27(66)59-33(15-8-21-56-47(51)52)41(69)61-34-14-7-17-39(67)55-23-19-32(40(50)68)60-46(74)38(25-29-26-58-31-13-6-5-12-30(29)31)65-43(71)35(16-9-22-57-48(53)54)62-45(73)37(24-28-10-3-2-4-11-28)64-44(72)36(18-20-49)63-42(34)70/h2-6,10-13,26,32-38,58H,7-9,14-25,49H2,1H3,(H2,50,68)(H,55,67)(H,59,66)(H,60,74)(H,61,69)(H,62,73)(H,63,70)(H,64,72)(H,65,71)(H4,51,52,56)(H4,53,54,57)/t32-,33-,34-,35-,36-,37+,38-/m0/s1
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Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


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More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135689
PNG
(US8846601, 74 | US9458201, 74)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C49H71N17O10/c1-27(67)60-33(15-8-22-57-48(52)53)42(71)64-36-18-20-40(69)56-21-7-14-32(41(51)70)61-47(76)38(25-29-26-59-31-13-6-5-12-30(29)31)66-43(72)34(16-9-23-58-49(54)55)62-46(75)37(24-28-10-3-2-4-11-28)65-45(74)35(63-44(36)73)17-19-39(50)68/h2-6,10-13,26,32-38,59H,7-9,14-25H2,1H3,(H2,50,68)(H2,51,70)(H,56,69)(H,60,67)(H,61,76)(H,62,75)(H,63,73)(H,64,71)(H,65,74)(H,66,72)(H4,52,53,57)(H4,54,55,58)/t32-,33-,34-,35-,36-,37+,38-/m0/s1
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Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


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More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135633
PNG
(US8846601, 18 | US9458201, 55)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](Cc3ccccc3)CN2C1=O)C(N)=O
Show InChI InChI=1S/C56H76N16O9/c1-33(73)66-41(21-12-24-63-55(58)59)49(76)71-45-30-47(74)62-23-11-10-20-40(48(57)75)67-52(79)44(29-37-31-65-39-19-9-8-18-38(37)39)69-50(77)42(22-13-25-64-56(60)61)68-51(78)43(27-35-16-6-3-7-17-35)70-53(80)46-28-36(32-72(46)54(45)81)26-34-14-4-2-5-15-34/h2-9,14-19,31,36,40-46,65H,10-13,20-30,32H2,1H3,(H2,57,75)(H,62,74)(H,66,73)(H,67,79)(H,68,78)(H,69,77)(H,70,80)(H,71,76)(H4,58,59,63)(H4,60,61,64)/t36-,40+,41+,42+,43-,44+,45+,46+/m1/s1
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Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135669
PNG
(US8846601, 54 | US9458201, 54)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@H](CN2C1=O)OCc1ccccc1)C(O)=O
Show InChI InChI=1S/C56H75N15O11/c1-33(72)65-40(21-12-24-62-55(57)58)48(74)70-45-29-47(73)61-23-11-10-20-42(54(80)81)67-51(77)44(27-36-30-64-39-19-9-8-18-38(36)39)68-49(75)41(22-13-25-63-56(59)60)66-50(76)43(26-34-14-4-2-5-15-34)69-52(78)46-28-37(31-71(46)53(45)79)82-32-35-16-6-3-7-17-35/h2-9,14-19,30,37,40-46,64H,10-13,20-29,31-32H2,1H3,(H,61,73)(H,65,72)(H,66,76)(H,67,77)(H,68,75)(H,69,78)(H,70,74)(H,80,81)(H4,57,58,62)(H4,59,60,63)/t37-,40+,41+,42+,43-,44+,45+,46+/m1/s1
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Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135634
PNG
(US8846601, 19 | US9458201, 19)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2cccc3ccccc23)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O
Show InChI InChI=1S/C54H72N18O9/c1-30(73)66-39(18-9-21-62-53(56)57)47(76)72-44-26-45(74)61-20-7-6-17-38(46(55)75)67-49(78)42(24-33-27-64-37-16-5-4-15-36(33)37)69-48(77)40(19-10-22-63-54(58)59)68-50(79)41(23-32-13-8-12-31-11-2-3-14-35(31)32)70-51(80)43(71-52(44)81)25-34-28-60-29-65-34/h2-5,8,11-16,27-29,38-44,64H,6-7,9-10,17-26H2,1H3,(H2,55,75)(H,60,65)(H,61,74)(H,66,73)(H,67,78)(H,68,79)(H,69,77)(H,70,80)(H,71,81)(H,72,76)(H4,56,57,62)(H4,58,59,63)/t38-,39-,40-,41+,42-,43-,44-/m0/s1
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Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM253653
PNG
(US9458201, 132)
Show SMILES CC(=O)N[C@@H](CCCCN)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O
Show InChI InChI=1S/C50H70N16O9/c1-29(67)60-36(15-7-8-20-51)44(70)62-37-16-9-21-56-42(68)19-18-35(43(52)69)61-48(74)40(24-31-26-58-34-14-6-5-13-33(31)34)65-45(71)38(17-10-22-57-50(53)54)63-47(73)39(23-30-11-3-2-4-12-30)64-49(75)41(66-46(37)72)25-32-27-55-28-59-32/h2-6,11-14,26-28,35-41,58H,7-10,15-25,51H2,1H3,(H2,52,69)(H,55,59)(H,56,68)(H,60,67)(H,61,74)(H,62,70)(H,63,73)(H,64,75)(H,65,71)(H,66,72)(H4,53,54,57)/t35-,36-,37-,38-,39+,40-,41-/m0/s1
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Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135716
PNG
(US8846601, 101 | US9458201, 101)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O)C(N)=O
Show InChI InChI=1S/C49H70N16O10/c1-27(66)59-34(15-8-20-56-48(51)52)42(70)62-36-17-18-40(68)55-19-7-14-33(41(50)69)60-45(73)38(23-29-25-58-32-13-6-5-12-31(29)32)63-43(71)35(16-9-21-57-49(53)54)61-44(72)37(22-28-10-3-2-4-11-28)64-46(74)39-24-30(67)26-65(39)47(36)75/h2-6,10-13,25,30,33-39,58,67H,7-9,14-24,26H2,1H3,(H2,50,69)(H,55,68)(H,59,66)(H,60,73)(H,61,72)(H,62,70)(H,63,71)(H,64,74)(H4,51,52,56)(H4,53,54,57)/t30-,33+,34+,35+,36+,37-,38+,39+/m1/s1
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Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135734
PNG
(US8846601, 119 | US9458201, 119)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCN)NC1=O)C(N)=O
Show InChI InChI=1S/C48H71N17O9/c1-27(66)59-33(14-8-22-56-47(51)52)41(69)61-34-15-7-21-55-39(67)18-17-32(40(50)68)60-46(74)38(25-29-26-58-31-13-6-5-12-30(29)31)65-43(71)35(16-9-23-57-48(53)54)62-45(73)37(24-28-10-3-2-4-11-28)64-44(72)36(19-20-49)63-42(34)70/h2-6,10-13,26,32-38,58H,7-9,14-25,49H2,1H3,(H2,50,68)(H,55,67)(H,59,66)(H,60,74)(H,61,69)(H,62,73)(H,63,70)(H,64,72)(H,65,71)(H4,51,52,56)(H4,53,54,57)/t32-,33-,34-,35-,36-,37+,38-/m0/s1
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3n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM253656
PNG
(US9458201, 146)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCC(=O)NCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O)C(O)=O
Show InChI InChI=1S/C49H69N15O11/c1-27(65)58-33(15-8-19-55-48(50)51)41(68)60-35-14-7-17-40(67)54-21-18-36(47(74)75)61-44(71)38(23-29-25-57-32-13-6-5-12-31(29)32)62-42(69)34(16-9-20-56-49(52)53)59-43(70)37(22-28-10-3-2-4-11-28)63-45(72)39-24-30(66)26-64(39)46(35)73/h2-6,10-13,25,30,33-39,57,66H,7-9,14-24,26H2,1H3,(H,54,67)(H,58,65)(H,59,70)(H,60,68)(H,61,71)(H,62,69)(H,63,72)(H,74,75)(H4,50,51,55)(H4,52,53,56)/t30-,33+,34+,35+,36+,37-,38+,39+/m1/s1
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Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135737
PNG
(US8846601, 122 | US9458201, 122)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCN)NC1=O)C(=O)NC1CC1
Show InChI InChI=1S/C51H75N17O9/c1-29(69)61-35(16-9-23-58-50(53)54)44(72)68-41-27-42(70)57-22-8-7-15-36(43(71)62-32-18-19-32)63-48(76)40(26-31-28-60-34-14-6-5-13-33(31)34)67-45(73)37(17-10-24-59-51(55)56)64-47(75)39(25-30-11-3-2-4-12-30)66-46(74)38(20-21-52)65-49(41)77/h2-6,11-14,28,32,35-41,60H,7-10,15-27,52H2,1H3,(H,57,70)(H,61,69)(H,62,71)(H,63,76)(H,64,75)(H,65,77)(H,66,74)(H,67,73)(H,68,72)(H4,53,54,58)(H4,55,56,59)/t35-,36-,37-,38-,39+,40-,41-/m0/s1
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Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135774
PNG
(US8846601, 159 | US9458201, 159)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCNC(=O)CCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C49H71N17O10/c1-27(67)60-33(15-8-21-57-48(52)53)42(71)64-36-20-23-56-40(69)17-7-14-32(41(51)70)61-47(76)38(25-29-26-59-31-13-6-5-12-30(29)31)66-43(72)34(16-9-22-58-49(54)55)62-46(75)37(24-28-10-3-2-4-11-28)65-44(73)35(63-45(36)74)18-19-39(50)68/h2-6,10-13,26,32-38,59H,7-9,14-25H2,1H3,(H2,50,68)(H2,51,70)(H,56,69)(H,60,67)(H,61,76)(H,62,75)(H,63,74)(H,64,71)(H,65,73)(H,66,72)(H4,52,53,57)(H4,54,55,58)/t32-,33-,34-,35-,36-,37+,38-/m0/s1
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4n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135760
PNG
(US8846601, 145 | US9458201, 145)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCC(=O)NCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCS(C)(=O)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C49H72N16O11S/c1-28(66)59-34(16-9-21-56-48(51)52)42(69)61-35-15-8-18-40(67)55-23-19-33(41(50)68)60-47(74)39(26-30-27-58-32-14-7-6-13-31(30)32)65-44(71)36(17-10-22-57-49(53)54)62-46(73)38(25-29-11-4-3-5-12-29)64-45(72)37(63-43(35)70)20-24-77(2,75)76/h3-7,11-14,27,33-39,58H,8-10,15-26H2,1-2H3,(H2,50,68)(H,55,67)(H,59,66)(H,60,74)(H,61,69)(H,62,73)(H,63,70)(H,64,72)(H,65,71)(H4,51,52,56)(H4,53,54,57)/t33-,34-,35-,36-,37-,38+,39-/m0/s1
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Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135766
PNG
(US8846601, 151 | US9458201, 151)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C49H71N17O10/c1-27(67)60-32(16-9-21-57-48(52)53)42(71)61-33-15-7-8-20-56-40(69)25-36(41(51)70)64-47(76)38(24-29-26-59-31-14-6-5-13-30(29)31)66-44(73)34(17-10-22-58-49(54)55)62-46(75)37(23-28-11-3-2-4-12-28)65-45(74)35(63-43(33)72)18-19-39(50)68/h2-6,11-14,26,32-38,59H,7-10,15-25H2,1H3,(H2,50,68)(H2,51,70)(H,56,69)(H,60,67)(H,61,71)(H,62,75)(H,63,72)(H,64,76)(H,65,74)(H,66,73)(H4,52,53,57)(H4,54,55,58)/t32-,33-,34-,35-,36-,37+,38-/m0/s1
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Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135643
PNG
(US8846601, 28 | US9458201, 28)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC1=O)C(N)=O
Show InChI InChI=1S/C50H75N19O9/c1-28(70)63-34(17-9-21-59-48(52)53)42(73)69-39-26-40(71)58-20-8-7-16-33(41(51)72)64-46(77)38(25-30-27-62-32-15-6-5-14-31(30)32)68-44(75)36(19-11-23-61-50(56)57)65-45(76)37(24-29-12-3-2-4-13-29)67-43(74)35(66-47(39)78)18-10-22-60-49(54)55/h2-6,12-15,27,33-39,62H,7-11,16-26H2,1H3,(H2,51,72)(H,58,71)(H,63,70)(H,64,77)(H,65,76)(H,66,78)(H,67,74)(H,68,75)(H,69,73)(H4,52,53,59)(H4,54,55,60)(H4,56,57,61)/t33-,34-,35-,36-,37+,38-,39-/m0/s1
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Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM253651
PNG
(US9458201, 98)
Show SMILES CC(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O
Show InChI InChI=1S/C50H70N18O9/c1-28(69)62-35(14-8-20-58-49(52)53)43(72)64-36-15-7-19-57-41(70)18-17-34(42(51)71)63-47(76)39(23-30-25-60-33-13-6-5-12-32(30)33)67-44(73)37(16-9-21-59-50(54)55)65-46(75)38(22-29-10-3-2-4-11-29)66-48(77)40(68-45(36)74)24-31-26-56-27-61-31/h2-6,10-13,25-27,34-40,60H,7-9,14-24H2,1H3,(H2,51,71)(H,56,61)(H,57,70)(H,62,69)(H,63,76)(H,64,72)(H,65,75)(H,66,77)(H,67,73)(H,68,74)(H4,52,53,58)(H4,54,55,59)/t34-,35+,36-,37-,38+,39-,40-/m0/s1
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Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135744
PNG
(US8846601, 129 | US9458201, 136)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCNC(=O)CCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCN)NC1=O)C(N)=O
Show InChI InChI=1S/C48H71N17O9/c1-27(66)59-33(15-8-21-56-47(51)52)41(69)63-36-19-23-55-39(67)17-7-14-32(40(50)68)60-46(74)38(25-29-26-58-31-13-6-5-12-30(29)31)65-42(70)34(16-9-22-57-48(53)54)61-45(73)37(24-28-10-3-2-4-11-28)64-43(71)35(18-20-49)62-44(36)72/h2-6,10-13,26,32-38,58H,7-9,14-25,49H2,1H3,(H2,50,68)(H,55,67)(H,59,66)(H,60,74)(H,61,73)(H,62,72)(H,63,69)(H,64,71)(H,65,70)(H4,51,52,56)(H4,53,54,57)/t32-,33-,34-,35-,36-,37+,38-/m0/s1
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Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135694
PNG
(US8846601, 79 | US9458201, 79)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](O)CN2C1=O)C(N)=O
Show InChI InChI=1S/C49H70N16O10/c1-27(66)59-34(16-9-19-56-48(51)52)42(70)64-38-24-40(68)55-18-8-7-15-33(41(50)69)60-45(73)37(22-29-25-58-32-14-6-5-13-31(29)32)62-43(71)35(17-10-20-57-49(53)54)61-44(72)36(21-28-11-3-2-4-12-28)63-46(74)39-23-30(67)26-65(39)47(38)75/h2-6,11-14,25,30,33-39,58,67H,7-10,15-24,26H2,1H3,(H2,50,69)(H,55,68)(H,59,66)(H,60,73)(H,61,72)(H,62,71)(H,63,74)(H,64,70)(H4,51,52,56)(H4,53,54,57)/t30-,33+,34+,35+,36-,37+,38+,39+/m1/s1
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Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135697
PNG
(US8846601, 82 | US9458201, 82)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(O)=O
Show InChI InChI=1S/C50H69N17O10/c1-28(68)61-34(14-7-20-57-49(51)52)42(70)63-36-17-18-41(69)56-19-9-16-37(48(76)77)64-46(74)39(23-30-25-59-33-13-6-5-12-32(30)33)66-43(71)35(15-8-21-58-50(53)54)62-45(73)38(22-29-10-3-2-4-11-29)65-47(75)40(67-44(36)72)24-31-26-55-27-60-31/h2-6,10-13,25-27,34-40,59H,7-9,14-24H2,1H3,(H,55,60)(H,56,69)(H,61,68)(H,62,73)(H,63,70)(H,64,74)(H,65,75)(H,66,71)(H,67,72)(H,76,77)(H4,51,52,57)(H4,53,54,58)/t34-,35-,36-,37-,38+,39-,40-/m0/s1
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Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135616
PNG
(US8846601, 1 | US8846601, 115 | US8846601, 51 | US...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O
Show InChI InChI=1S/C50H70N18O9/c1-28(69)62-35(16-9-19-58-49(52)53)43(72)68-40-24-41(70)57-18-8-7-15-34(42(51)71)63-46(75)38(22-30-25-60-33-14-6-5-13-32(30)33)66-44(73)36(17-10-20-59-50(54)55)64-45(74)37(21-29-11-3-2-4-12-29)65-47(76)39(67-48(40)77)23-31-26-56-27-61-31/h2-6,11-14,25-27,34-40,60H,7-10,15-24H2,1H3,(H2,51,71)(H,56,61)(H,57,70)(H,62,69)(H,63,75)(H,64,74)(H,65,76)(H,66,73)(H,67,77)(H,68,72)(H4,52,53,58)(H4,54,55,59)/t34-,35-,36-,37+,38-,39-,40-/m0/s1
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Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135770
PNG
(US8846601, 155 | US9458201, 155)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C48H69N17O10/c1-26(66)59-31(16-9-19-56-47(51)52)41(70)60-32-15-7-8-18-55-39(68)24-34(40(50)69)62-45(74)36(22-28-25-58-30-14-6-5-13-29(28)30)64-43(72)33(17-10-20-57-48(53)54)61-44(73)35(21-27-11-3-2-4-12-27)63-46(75)37(23-38(49)67)65-42(32)71/h2-6,11-14,25,31-37,58H,7-10,15-24H2,1H3,(H2,49,67)(H2,50,69)(H,55,68)(H,59,66)(H,60,70)(H,61,73)(H,62,74)(H,63,75)(H,64,72)(H,65,71)(H4,51,52,56)(H4,53,54,57)/t31-,32-,33-,34-,35+,36-,37-/m0/s1
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Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135695
PNG
(US8846601, 80 | US9458201, 80)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](N)CN2C1=O)C(N)=O
Show InChI InChI=1S/C49H71N17O9/c1-27(67)60-34(16-9-19-57-48(52)53)42(70)65-38-24-40(68)56-18-8-7-15-33(41(51)69)61-45(73)37(22-29-25-59-32-14-6-5-13-31(29)32)63-43(71)35(17-10-20-58-49(54)55)62-44(72)36(21-28-11-3-2-4-12-28)64-46(74)39-23-30(50)26-66(39)47(38)75/h2-6,11-14,25,30,33-39,59H,7-10,15-24,26,50H2,1H3,(H2,51,69)(H,56,68)(H,60,67)(H,61,73)(H,62,72)(H,63,71)(H,64,74)(H,65,70)(H4,52,53,57)(H4,54,55,58)/t30-,33+,34+,35+,36-,37+,38+,39+/m1/s1
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Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135777
PNG
(US8846601, 162 | US9458201, 162)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C50H70N16O10/c1-28(67)60-33(16-9-21-58-49(53)54)43(71)61-34-15-7-8-20-57-41(69)27-36(42(52)70)63-47(75)38(25-30-18-19-31-13-5-6-14-32(31)23-30)64-45(73)35(17-10-22-59-50(55)56)62-46(74)37(24-29-11-3-2-4-12-29)65-48(76)39(26-40(51)68)66-44(34)72/h2-6,11-14,18-19,23,33-39H,7-10,15-17,20-22,24-27H2,1H3,(H2,51,68)(H2,52,70)(H,57,69)(H,60,67)(H,61,71)(H,62,74)(H,63,75)(H,64,73)(H,65,76)(H,66,72)(H4,53,54,58)(H4,55,56,59)/t33-,34-,35-,36-,37+,38-,39-/m0/s1
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5n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135765
PNG
(US8846601, 150 | US9458201, 150)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C49H71N17O10/c1-27(67)60-33(14-8-22-57-48(52)53)42(71)62-34-15-7-21-56-40(69)20-18-32(41(51)70)61-47(76)38(25-29-26-59-31-13-6-5-12-30(29)31)66-44(73)35(16-9-23-58-49(54)55)63-46(75)37(24-28-10-3-2-4-11-28)65-45(74)36(64-43(34)72)17-19-39(50)68/h2-6,10-13,26,32-38,59H,7-9,14-25H2,1H3,(H2,50,68)(H2,51,70)(H,56,69)(H,60,67)(H,61,76)(H,62,71)(H,63,75)(H,64,72)(H,65,74)(H,66,73)(H4,52,53,57)(H4,54,55,58)/t32-,33-,34-,35-,36-,37+,38-/m0/s1
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5n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


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More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135776
PNG
(US8846601, 161 | US9458201, 161)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C48H69N17O10/c1-26(66)59-32(15-8-20-56-47(51)52)41(70)62-34-17-18-39(68)55-19-7-14-31(40(50)69)60-45(74)36(23-28-25-58-30-13-6-5-12-29(28)30)64-42(71)33(16-9-21-57-48(53)54)61-44(73)35(22-27-10-3-2-4-11-27)63-46(75)37(24-38(49)67)65-43(34)72/h2-6,10-13,25,31-37,58H,7-9,14-24H2,1H3,(H2,49,67)(H2,50,69)(H,55,68)(H,59,66)(H,60,74)(H,61,73)(H,62,70)(H,63,75)(H,64,71)(H,65,72)(H4,51,52,56)(H4,53,54,57)/t31-,32-,33-,34-,35+,36-,37-/m0/s1
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6n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135727
PNG
(US8846601, 112 | US9458201, 112)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](N)CN2C1=O)C(N)=O
Show InChI InChI=1S/C49H71N17O9/c1-27(67)60-34(15-8-20-57-48(52)53)42(70)63-36-17-18-40(68)56-19-7-14-33(41(51)69)61-45(73)38(23-29-25-59-32-13-6-5-12-31(29)32)64-43(71)35(16-9-21-58-49(54)55)62-44(72)37(22-28-10-3-2-4-11-28)65-46(74)39-24-30(50)26-66(39)47(36)75/h2-6,10-13,25,30,33-39,59H,7-9,14-24,26,50H2,1H3,(H2,51,69)(H,56,68)(H,60,67)(H,61,73)(H,62,72)(H,63,70)(H,64,71)(H,65,74)(H4,52,53,57)(H4,54,55,58)/t30-,33+,34+,35+,36+,37-,38+,39+/m1/s1
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6n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135767
PNG
(US8846601, 152 | US9458201, 152)
Show SMILES CC(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C49H71N17O10/c1-27(67)60-33(14-8-22-57-48(52)53)42(71)62-34-15-7-21-56-40(69)20-18-32(41(51)70)61-47(76)38(25-29-26-59-31-13-6-5-12-30(29)31)66-44(73)35(16-9-23-58-49(54)55)63-46(75)37(24-28-10-3-2-4-11-28)65-45(74)36(64-43(34)72)17-19-39(50)68/h2-6,10-13,26,32-38,59H,7-9,14-25H2,1H3,(H2,50,68)(H2,51,70)(H,56,69)(H,60,67)(H,61,76)(H,62,71)(H,63,75)(H,64,72)(H,65,74)(H,66,73)(H4,52,53,57)(H4,54,55,58)/t32-,33+,34-,35-,36-,37+,38-/m0/s1
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6n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135720
PNG
(US8846601, 105 | US9458201, 105)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C50H74N18O10/c1-28(69)62-34(16-8-22-58-48(52)53)42(72)66-37-19-20-40(70)57-21-7-15-33(41(51)71)63-47(77)39(26-30-27-61-32-14-6-5-13-31(30)32)68-44(74)36(17-9-23-59-49(54)55)65-46(76)38(25-29-11-3-2-4-12-29)67-43(73)35(64-45(37)75)18-10-24-60-50(56)78/h2-6,11-14,27,33-39,61H,7-10,15-26H2,1H3,(H2,51,71)(H,57,70)(H,62,69)(H,63,77)(H,64,75)(H,65,76)(H,66,72)(H,67,73)(H,68,74)(H4,52,53,58)(H4,54,55,59)(H3,56,60,78)/t33-,34-,35-,36-,37-,38+,39-/m0/s1
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6n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135724
PNG
(US8846601, 109 | US9458201, 109)
Show SMILES CCNC(=O)[C@@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1
Show InChI InChI=1S/C52H74N18O9/c1-3-58-44(73)36-16-9-21-59-43(72)20-19-39(67-45(74)37(64-30(2)71)17-10-22-60-51(53)54)47(76)70-42(26-33-28-57-29-63-33)50(79)68-40(24-31-12-5-4-6-13-31)48(77)66-38(18-11-23-61-52(55)56)46(75)69-41(49(78)65-36)25-32-27-62-35-15-8-7-14-34(32)35/h4-8,12-15,27-29,36-42,62H,3,9-11,16-26H2,1-2H3,(H,57,63)(H,58,73)(H,59,72)(H,64,71)(H,65,78)(H,66,77)(H,67,74)(H,68,79)(H,69,75)(H,70,76)(H4,53,54,60)(H4,55,56,61)/t36-,37-,38-,39-,40+,41-,42-/m0/s1
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6n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135714
PNG
(US8846601, 99 | US9458201, 99)
Show SMILES N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O
Show InChI InChI=1S/C48H68N18O8/c49-31(12-6-19-57-47(51)52)41(69)62-34-14-7-18-56-39(67)17-16-33(40(50)68)61-45(73)37(22-28-24-59-32-13-5-4-11-30(28)32)65-43(71)35(15-8-20-58-48(53)54)63-44(72)36(21-27-9-2-1-3-10-27)64-46(74)38(66-42(34)70)23-29-25-55-26-60-29/h1-5,9-11,13,24-26,31,33-38,59H,6-8,12,14-23,49H2,(H2,50,68)(H,55,60)(H,56,67)(H,61,73)(H,62,69)(H,63,72)(H,64,74)(H,65,71)(H,66,70)(H4,51,52,57)(H4,53,54,58)/t31-,33-,34-,35-,36+,37-,38-/m0/s1
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6n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135692
PNG
(US8846601, 77 | US9458201, 77)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCS(C)(=O)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C49H72N16O11S/c1-28(66)59-34(17-10-21-56-48(51)52)42(69)65-39-26-40(67)55-20-9-8-16-33(41(50)68)60-46(73)38(25-30-27-58-32-15-7-6-14-31(30)32)64-43(70)35(18-11-22-57-49(53)54)61-45(72)37(24-29-12-4-3-5-13-29)63-44(71)36(62-47(39)74)19-23-77(2,75)76/h3-7,12-15,27,33-39,58H,8-11,16-26H2,1-2H3,(H2,50,68)(H,55,67)(H,59,66)(H,60,73)(H,61,72)(H,62,74)(H,63,71)(H,64,70)(H,65,69)(H4,51,52,56)(H4,53,54,57)/t33-,34-,35-,36-,37+,38-,39-/m0/s1
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7n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135764
PNG
(US8846601, 149 | US9458201, 149)
Show SMILES CC(=O)NCCC[C@@H]1NC(=O)[C@H](CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O
Show InChI InChI=1S/C51H75N17O10/c1-29(69)57-22-9-18-37-45(74)67-40(26-31-12-4-3-5-13-31)48(77)65-38(19-11-25-60-51(55)56)46(75)68-41(27-32-28-61-34-15-7-6-14-33(32)34)49(78)63-35(43(52)72)16-8-23-58-42(71)21-20-39(47(76)64-37)66-44(73)36(62-30(2)70)17-10-24-59-50(53)54/h3-7,12-15,28,35-41,61H,8-11,16-27H2,1-2H3,(H2,52,72)(H,57,69)(H,58,71)(H,62,70)(H,63,78)(H,64,76)(H,65,77)(H,66,73)(H,67,74)(H,68,75)(H4,53,54,59)(H4,55,56,60)/t35-,36-,37-,38-,39-,40+,41-/m0/s1
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7n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135682
PNG
(US8846601, 67 | US9458201, 67)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCN)NC1=O)C(N)=O
Show InChI InChI=1S/C49H73N17O9/c1-28(67)60-34(18-10-22-57-48(52)53)42(70)66-39-26-40(68)56-21-8-7-16-33(41(51)69)61-46(74)38(25-30-27-59-32-15-6-5-14-31(30)32)65-44(72)36(19-11-23-58-49(54)55)63-45(73)37(24-29-12-3-2-4-13-29)64-43(71)35(17-9-20-50)62-47(39)75/h2-6,12-15,27,33-39,59H,7-11,16-26,50H2,1H3,(H2,51,69)(H,56,68)(H,60,67)(H,61,74)(H,62,75)(H,63,73)(H,64,71)(H,65,72)(H,66,70)(H4,52,53,57)(H4,54,55,58)/t33-,34-,35-,36-,37+,38-,39-/m0/s1
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7n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135684
PNG
(US8846601, 69 | US9458201, 69)
Show SMILES CC(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O
Show InChI InChI=1S/C50H70N18O9/c1-28(69)62-35(16-9-19-58-49(52)53)43(72)68-40-24-41(70)57-18-8-7-15-34(42(51)71)63-46(75)38(22-30-25-60-33-14-6-5-13-32(30)33)66-44(73)36(17-10-20-59-50(54)55)64-45(74)37(21-29-11-3-2-4-12-29)65-47(76)39(67-48(40)77)23-31-26-56-27-61-31/h2-6,11-14,25-27,34-40,60H,7-10,15-24H2,1H3,(H2,51,71)(H,56,61)(H,57,70)(H,62,69)(H,63,75)(H,64,74)(H,65,76)(H,66,73)(H,67,77)(H,68,72)(H4,52,53,58)(H4,54,55,59)/t34-,35+,36-,37+,38-,39-,40-/m0/s1
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8n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135738
PNG
(US8846601, 123 | US9458201, 123)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](Cc3ccccc3Cl)CN2C1=O)C(N)=O
Show InChI InChI=1S/C56H75ClN16O9/c1-32(74)67-41(20-11-23-64-55(59)60)49(77)72-45-29-47(75)63-22-10-9-19-40(48(58)76)68-52(80)44(28-36-30-66-39-18-8-6-16-37(36)39)70-50(78)42(21-12-24-65-56(61)62)69-51(79)43(26-33-13-3-2-4-14-33)71-53(81)46-27-34(31-73(46)54(45)82)25-35-15-5-7-17-38(35)57/h2-8,13-18,30,34,40-46,66H,9-12,19-29,31H2,1H3,(H2,58,76)(H,63,75)(H,67,74)(H,68,80)(H,69,79)(H,70,78)(H,71,81)(H,72,77)(H4,59,60,64)(H4,61,62,65)/t34-,40+,41+,42+,43-,44+,45+,46+/m1/s1
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8n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135748
PNG
(US8846601, 133 | US9458201, 133)
Show SMILES CC(=O)N[C@H](CCCCN)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O
Show InChI InChI=1S/C50H70N16O9/c1-29(67)60-36(15-7-8-20-51)44(70)62-37-16-9-21-56-42(68)19-18-35(43(52)69)61-48(74)40(24-31-26-58-34-14-6-5-13-33(31)34)65-45(71)38(17-10-22-57-50(53)54)63-47(73)39(23-30-11-3-2-4-12-30)64-49(75)41(66-46(37)72)25-32-27-55-28-59-32/h2-6,11-14,26-28,35-41,58H,7-10,15-25,51H2,1H3,(H2,52,69)(H,55,59)(H,56,68)(H,60,67)(H,61,74)(H,62,70)(H,63,73)(H,64,75)(H,65,71)(H,66,72)(H4,53,54,57)/t35-,36+,37-,38-,39+,40-,41-/m0/s1
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8n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135775
PNG
(US8846601, 160 | US9458201, 160)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCC(=O)NCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C48H69N17O10/c1-26(66)59-32(15-8-19-56-47(51)52)41(70)61-33-14-7-17-39(68)55-21-18-31(40(50)69)60-45(74)36(23-28-25-58-30-13-6-5-12-29(28)30)64-43(72)34(16-9-20-57-48(53)54)62-44(73)35(22-27-10-3-2-4-11-27)63-46(75)37(24-38(49)67)65-42(33)71/h2-6,10-13,25,31-37,58H,7-9,14-24H2,1H3,(H2,49,67)(H2,50,69)(H,55,68)(H,59,66)(H,60,74)(H,61,70)(H,62,73)(H,63,75)(H,64,72)(H,65,71)(H4,51,52,56)(H4,53,54,57)/t31-,32-,33-,34-,35+,36-,37-/m0/s1
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8n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


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More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135715
PNG
(US8846601, 100 | US9458201, 100)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCS(C)(=O)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C49H72N16O11S/c1-28(66)59-34(16-9-22-56-48(51)52)42(69)62-36-18-19-40(67)55-21-8-15-33(41(50)68)60-47(74)39(26-30-27-58-32-14-7-6-13-31(30)32)65-43(70)35(17-10-23-57-49(53)54)61-46(73)38(25-29-11-4-3-5-12-29)64-45(72)37(63-44(36)71)20-24-77(2,75)76/h3-7,11-14,27,33-39,58H,8-10,15-26H2,1-2H3,(H2,50,68)(H,55,67)(H,59,66)(H,60,74)(H,61,73)(H,62,69)(H,63,71)(H,64,72)(H,65,70)(H4,51,52,56)(H4,53,54,57)/t33-,34-,35-,36-,37-,38+,39-/m0/s1
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8n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM253655
PNG
(US9458201, 141)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCN)NC1=O)C(N)=O
Show InChI InChI=1S/C48H71N17O9/c1-27(66)59-33(16-9-21-56-47(51)52)41(69)65-38-25-39(67)55-20-8-7-15-32(40(50)68)60-45(73)37(24-29-26-58-31-14-6-5-13-30(29)31)64-42(70)34(17-10-22-57-48(53)54)61-44(72)36(23-28-11-3-2-4-12-28)63-43(71)35(18-19-49)62-46(38)74/h2-6,11-14,26,32-38,58H,7-10,15-25,49H2,1H3,(H2,50,68)(H,55,67)(H,59,66)(H,60,73)(H,61,72)(H,62,74)(H,63,71)(H,64,70)(H,65,69)(H4,51,52,56)(H4,53,54,57)/t32-,33-,34-,35-,36+,37-,38-/m0/s1
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9n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135719
PNG
(US8846601, 104 | US9458201, 104)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCN)NC1=O)C(N)=O
Show InChI InChI=1S/C49H73N17O9/c1-28(67)60-34(17-9-23-57-48(52)53)42(70)64-37-19-20-40(68)56-22-8-16-33(41(51)69)61-47(75)39(26-30-27-59-32-14-6-5-13-31(30)32)66-44(72)36(18-10-24-58-49(54)55)63-46(74)38(25-29-11-3-2-4-12-29)65-43(71)35(15-7-21-50)62-45(37)73/h2-6,11-14,27,33-39,59H,7-10,15-26,50H2,1H3,(H2,51,69)(H,56,68)(H,60,67)(H,61,75)(H,62,73)(H,63,74)(H,64,70)(H,65,71)(H,66,72)(H4,52,53,57)(H4,54,55,58)/t33-,34-,35-,36-,37-,38+,39-/m0/s1
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9n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


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More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135750
PNG
(US8846601, 135 | US9458201, 135)
Show SMILES CC(=O)N[C@@H](CCCCN)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O
Show InChI InChI=1S/C50H70N16O9/c1-29(67)60-36(17-7-9-19-51)44(70)66-41-25-42(68)56-20-10-8-16-35(43(52)69)61-47(73)39(23-31-26-58-34-15-6-5-14-33(31)34)64-45(71)37(18-11-21-57-50(53)54)62-46(72)38(22-30-12-3-2-4-13-30)63-48(74)40(65-49(41)75)24-32-27-55-28-59-32/h2-6,12-15,26-28,35-41,58H,7-11,16-25,51H2,1H3,(H2,52,69)(H,55,59)(H,56,68)(H,60,67)(H,61,73)(H,62,72)(H,63,74)(H,64,71)(H,65,75)(H,66,70)(H4,53,54,57)/t35-,36-,37-,38+,39-,40-,41-/m0/s1
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9n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135726
PNG
(US8846601, 111 | US9458201, 111)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCS(C)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C49H72N16O10S/c1-28(66)59-34(16-9-22-56-48(51)52)42(69)62-36-18-19-40(67)55-21-8-15-33(41(50)68)60-47(74)39(26-30-27-58-32-14-7-6-13-31(30)32)65-43(70)35(17-10-23-57-49(53)54)61-46(73)38(25-29-11-4-3-5-12-29)64-45(72)37(63-44(36)71)20-24-76(2)75/h3-7,11-14,27,33-39,58H,8-10,15-26H2,1-2H3,(H2,50,68)(H,55,67)(H,59,66)(H,60,74)(H,61,73)(H,62,69)(H,63,71)(H,64,72)(H,65,70)(H4,51,52,56)(H4,53,54,57)/t33-,34-,35-,36-,37-,38+,39-,76?/m0/s1
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9n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135705
PNG
(US8846601, 90 | US9458201, 90)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCN)NC1=O)C(O)=O
Show InChI InChI=1S/C49H72N16O10/c1-28(66)59-33(16-8-23-56-48(51)52)41(68)62-36-19-20-40(67)55-22-10-18-37(47(74)75)63-46(73)39(26-30-27-58-32-14-6-5-13-31(30)32)65-43(70)35(17-9-24-57-49(53)54)61-45(72)38(25-29-11-3-2-4-12-29)64-42(69)34(15-7-21-50)60-44(36)71/h2-6,11-14,27,33-39,58H,7-10,15-26,50H2,1H3,(H,55,67)(H,59,66)(H,60,71)(H,61,72)(H,62,68)(H,63,73)(H,64,69)(H,65,70)(H,74,75)(H4,51,52,56)(H4,53,54,57)/t33-,34-,35-,36-,37-,38+,39-/m0/s1
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9n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135699
PNG
(US8846601, 84 | US9458201, 84)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(O)=O
Show InChI InChI=1S/C50H69N17O10/c1-28(68)61-34(14-8-20-57-49(51)52)42(70)62-35-15-7-19-56-41(69)18-17-37(48(76)77)64-46(74)39(23-30-25-59-33-13-6-5-12-32(30)33)66-43(71)36(16-9-21-58-50(53)54)63-45(73)38(22-29-10-3-2-4-11-29)65-47(75)40(67-44(35)72)24-31-26-55-27-60-31/h2-6,10-13,25-27,34-40,59H,7-9,14-24H2,1H3,(H,55,60)(H,56,69)(H,61,68)(H,62,70)(H,63,73)(H,64,74)(H,65,75)(H,66,71)(H,67,72)(H,76,77)(H4,51,52,57)(H4,53,54,58)/t34-,35-,36-,37-,38+,39-,40-/m0/s1
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12n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135633
PNG
(US8846601, 18 | US9458201, 55)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](Cc3ccccc3)CN2C1=O)C(N)=O
Show InChI InChI=1S/C56H76N16O9/c1-33(73)66-41(21-12-24-63-55(58)59)49(76)71-45-30-47(74)62-23-11-10-20-40(48(57)75)67-52(79)44(29-37-31-65-39-19-9-8-18-38(37)39)69-50(77)42(22-13-25-64-56(60)61)68-51(78)43(27-35-16-6-3-7-17-35)70-53(80)46-28-36(32-72(46)54(45)81)26-34-14-4-2-5-15-34/h2-9,14-19,31,36,40-46,65H,10-13,20-30,32H2,1H3,(H2,57,75)(H,62,74)(H,66,73)(H,67,79)(H,68,78)(H,69,77)(H,70,80)(H,71,76)(H4,58,59,63)(H4,60,61,64)/t36-,40+,41+,42+,43-,44+,45+,46+/m1/s1
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12n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135769
PNG
(US8846601, 154 | US8846601, 202 | US9458201, 154)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C48H69N17O10/c1-26(66)59-32(14-8-20-56-47(51)52)41(70)61-33-15-7-19-55-39(68)18-17-31(40(50)69)60-45(74)36(23-28-25-58-30-13-6-5-12-29(28)30)64-42(71)34(16-9-21-57-48(53)54)62-44(73)35(22-27-10-3-2-4-11-27)63-46(75)37(24-38(49)67)65-43(33)72/h2-6,10-13,25,31-37,58H,7-9,14-24H2,1H3,(H2,49,67)(H2,50,69)(H,55,68)(H,59,66)(H,60,74)(H,61,70)(H,62,73)(H,63,75)(H,64,71)(H,65,72)(H4,51,52,56)(H4,53,54,57)/t31-,32-,33-,34-,35+,36-,37-/m0/s1
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13n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135758
PNG
(US8846601, 143 | US9458201, 143)
Show SMILES CC(=O)NCC[C@@H]1NC(=O)[C@H](CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O
Show InChI InChI=1S/C50H73N17O10/c1-28(68)56-24-20-38-46(75)66-39(25-30-11-4-3-5-12-30)47(76)63-36(17-10-23-59-50(54)55)44(73)67-40(26-31-27-60-33-14-7-6-13-32(31)33)48(77)62-34(42(51)71)15-8-21-57-41(70)19-18-37(45(74)65-38)64-43(72)35(61-29(2)69)16-9-22-58-49(52)53/h3-7,11-14,27,34-40,60H,8-10,15-26H2,1-2H3,(H2,51,71)(H,56,68)(H,57,70)(H,61,69)(H,62,77)(H,63,76)(H,64,72)(H,65,74)(H,66,75)(H,67,73)(H4,52,53,58)(H4,54,55,59)/t34-,35-,36-,37-,38-,39+,40-/m0/s1
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13n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135647
PNG
(US8846601, 32 | US8846601, 57 | US9458201, 32)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C49H71N17O10/c1-27(67)60-33(16-9-21-57-48(52)53)42(71)66-38-25-40(69)56-20-8-7-15-32(41(51)70)61-46(75)37(24-29-26-59-31-14-6-5-13-30(29)31)65-43(72)34(17-10-22-58-49(54)55)62-45(74)36(23-28-11-3-2-4-12-28)64-44(73)35(63-47(38)76)18-19-39(50)68/h2-6,11-14,26,32-38,59H,7-10,15-25H2,1H3,(H2,50,68)(H2,51,70)(H,56,69)(H,60,67)(H,61,75)(H,62,74)(H,63,76)(H,64,73)(H,65,72)(H,66,71)(H4,52,53,57)(H4,54,55,58)/t32-,33-,34-,35-,36+,37-,38-/m0/s1
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13n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135691
PNG
(US8846601, 76 | US9458201, 76)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C50H74N18O10/c1-28(69)62-34(17-9-21-58-48(52)53)42(72)68-39-26-40(70)57-20-8-7-16-33(41(51)71)63-46(76)38(25-30-27-61-32-15-6-5-14-31(30)32)67-44(74)35(18-10-22-59-49(54)55)64-45(75)37(24-29-12-3-2-4-13-29)66-43(73)36(65-47(39)77)19-11-23-60-50(56)78/h2-6,12-15,27,33-39,61H,7-11,16-26H2,1H3,(H2,51,71)(H,57,70)(H,62,69)(H,63,76)(H,64,75)(H,65,77)(H,66,73)(H,67,74)(H,68,72)(H4,52,53,58)(H4,54,55,59)(H3,56,60,78)/t33-,34-,35-,36-,37+,38-,39-/m0/s1
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14n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


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Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135757
PNG
(US8846601, 142 | US9458201, 142)
Show SMILES CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCN)NC1=O)C(N)=O
Show InChI InChI=1S/C47H67N15O10/c1-26(63)56-33(16-17-38(49)64)42(68)62-37-24-39(65)53-20-8-7-14-31(40(50)66)57-45(71)36(23-28-25-55-30-13-6-5-12-29(28)30)61-41(67)32(15-9-21-54-47(51)52)58-44(70)35(22-27-10-3-2-4-11-27)60-43(69)34(18-19-48)59-46(37)72/h2-6,10-13,25,31-37,55H,7-9,14-24,48H2,1H3,(H2,49,64)(H2,50,66)(H,53,65)(H,56,63)(H,57,71)(H,58,70)(H,59,72)(H,60,69)(H,61,67)(H,62,68)(H4,51,52,54)/t31-,32-,33-,34-,35+,36-,37-/m0/s1
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15n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


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More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135718
PNG
(US8846601, 103 | US9458201, 103)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCCN)NC1=O)C(N)=O
Show InChI InChI=1S/C50H75N17O9/c1-29(68)61-35(18-10-24-58-49(53)54)43(71)65-38-20-21-41(69)57-23-9-17-34(42(52)70)62-48(76)40(27-31-28-60-33-15-6-5-14-32(31)33)67-45(73)37(19-11-25-59-50(55)56)64-47(75)39(26-30-12-3-2-4-13-30)66-44(72)36(63-46(38)74)16-7-8-22-51/h2-6,12-15,28,34-40,60H,7-11,16-27,51H2,1H3,(H2,52,70)(H,57,69)(H,61,68)(H,62,76)(H,63,74)(H,64,75)(H,65,71)(H,66,72)(H,67,73)(H4,53,54,58)(H4,55,56,59)/t34-,35-,36-,37-,38-,39+,40-/m0/s1
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Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135678
PNG
(US8846601, 63 | US9458201, 63)
Show SMILES CN1CC(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCCCNC(=O)C[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)C1=O)C(N)=O
Show InChI InChI=1S/C47H68N16O9/c1-27(64)57-33(17-10-20-54-46(49)50)41(68)62-37-24-38(65)53-19-9-8-16-32(40(48)67)59-44(71)36(23-29-25-56-31-15-7-6-14-30(29)31)61-42(69)34(18-11-21-55-47(51)52)60-43(70)35(22-28-12-4-3-5-13-28)58-39(66)26-63(2)45(37)72/h3-7,12-15,25,32-37,56H,8-11,16-24,26H2,1-2H3,(H2,48,67)(H,53,65)(H,57,64)(H,58,66)(H,59,71)(H,60,70)(H,61,69)(H,62,68)(H4,49,50,54)(H4,51,52,55)/t32-,33-,34-,35+,36-,37-/m0/s1
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Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


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More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135664
PNG
(US8846601, 49 | US9458201, 49)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cccc(c2)C(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C54H73N17O10/c1-30(72)65-38(19-10-22-62-53(57)58)47(76)71-43-28-44(73)61-21-8-7-18-37(46(56)75)66-51(80)42(27-34-29-64-36-17-6-5-16-35(34)36)70-48(77)39(20-11-23-63-54(59)60)67-49(78)40(25-31-12-3-2-4-13-31)68-50(79)41(69-52(43)81)26-32-14-9-15-33(24-32)45(55)74/h2-6,9,12-17,24,29,37-43,64H,7-8,10-11,18-23,25-28H2,1H3,(H2,55,74)(H2,56,75)(H,61,73)(H,65,72)(H,66,80)(H,67,78)(H,68,79)(H,69,81)(H,70,77)(H,71,76)(H4,57,58,62)(H4,59,60,63)/t37-,38-,39-,40+,41-,42-,43-/m0/s1
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Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135735
PNG
(US8846601, 120 | US9458201, 120)
Show SMILES C[C@@H]1NC(=O)[C@H](CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O
Show InChI InChI=1S/C47H68N16O9/c1-26-40(67)62-36(23-28-11-4-3-5-12-28)44(71)61-35(17-10-22-55-47(51)52)43(70)63-37(24-29-25-56-31-14-7-6-13-30(29)31)45(72)59-32(39(48)66)18-19-38(65)53-20-8-16-34(41(68)57-26)60-42(69)33(58-27(2)64)15-9-21-54-46(49)50/h3-7,11-14,25-26,32-37,56H,8-10,15-24H2,1-2H3,(H2,48,66)(H,53,65)(H,57,68)(H,58,64)(H,59,72)(H,60,69)(H,61,71)(H,62,67)(H,63,70)(H4,49,50,54)(H4,51,52,55)/t26-,32-,33-,34-,35-,36+,37-/m0/s1
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19n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


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More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135649
PNG
(US8846601, 34 | US9458201, 34)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O
Show InChI InChI=1S/C50H74N16O9/c1-4-28(2)41-48(75)65-37(24-30-14-6-5-7-15-30)45(72)62-36(20-13-23-58-50(54)55)44(71)63-38(25-31-27-59-33-17-9-8-16-32(31)33)46(73)61-34(42(51)69)18-10-11-21-56-40(68)26-39(47(74)66-41)64-43(70)35(60-29(3)67)19-12-22-57-49(52)53/h5-9,14-17,27-28,34-39,41,59H,4,10-13,18-26H2,1-3H3,(H2,51,69)(H,56,68)(H,60,67)(H,61,73)(H,62,72)(H,63,71)(H,64,70)(H,65,75)(H,66,74)(H4,52,53,57)(H4,54,55,58)/t28-,34-,35-,36-,37+,38-,39-,41-/m0/s1
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19n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135624
PNG
(US8846601, 52 | US8846601, 9 | US9458201, 52)
Show SMILES C[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O
Show InChI InChI=1S/C47H68N16O9/c1-26-40(67)61-35(22-28-12-4-3-5-13-28)44(71)60-34(18-11-21-55-47(51)52)42(69)62-36(23-29-25-56-31-15-7-6-14-30(29)31)45(72)59-32(39(48)66)16-8-9-19-53-38(65)24-37(43(70)57-26)63-41(68)33(58-27(2)64)17-10-20-54-46(49)50/h3-7,12-15,25-26,32-37,56H,8-11,16-24H2,1-2H3,(H2,48,66)(H,53,65)(H,57,70)(H,58,64)(H,59,72)(H,60,71)(H,61,67)(H,62,69)(H,63,68)(H4,49,50,54)(H4,51,52,55)/t26-,32-,33-,34-,35+,36-,37-/m0/s1
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Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135739
PNG
(US8846601, 124 | US9458201, 124)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](Cc3cccc(Cl)c3)CN2C1=O)C(N)=O
Show InChI InChI=1S/C56H75ClN16O9/c1-32(74)67-41(19-10-22-64-55(59)60)49(77)72-45-29-47(75)63-21-8-7-18-40(48(58)76)68-52(80)44(28-36-30-66-39-17-6-5-16-38(36)39)70-50(78)42(20-11-23-65-56(61)62)69-51(79)43(26-33-12-3-2-4-13-33)71-53(81)46-27-35(31-73(46)54(45)82)24-34-14-9-15-37(57)25-34/h2-6,9,12-17,25,30,35,40-46,66H,7-8,10-11,18-24,26-29,31H2,1H3,(H2,58,76)(H,63,75)(H,67,74)(H,68,80)(H,69,79)(H,70,78)(H,71,81)(H,72,77)(H4,59,60,64)(H4,61,62,65)/t35-,40+,41+,42+,43-,44+,45+,46+/m1/s1
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Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135762
PNG
(US8846601, 147 | US9458201, 147)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCC(=O)NCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C49H71N17O10/c1-27(67)60-33(15-8-21-57-48(52)53)42(71)62-34-14-7-17-40(69)56-23-20-32(41(51)70)61-47(76)38(25-29-26-59-31-13-6-5-12-30(29)31)66-44(73)35(16-9-22-58-49(54)55)63-46(75)37(24-28-10-3-2-4-11-28)65-45(74)36(64-43(34)72)18-19-39(50)68/h2-6,10-13,26,32-38,59H,7-9,14-25H2,1H3,(H2,50,68)(H2,51,70)(H,56,69)(H,60,67)(H,61,76)(H,62,71)(H,63,75)(H,64,72)(H,65,74)(H,66,73)(H4,52,53,57)(H4,54,55,58)/t32-,33-,34-,35-,36-,37+,38-/m0/s1
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Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135616
PNG
(US8846601, 1 | US8846601, 115 | US8846601, 51 | US...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O
Show InChI InChI=1S/C50H70N18O9/c1-28(69)62-35(16-9-19-58-49(52)53)43(72)68-40-24-41(70)57-18-8-7-15-34(42(51)71)63-46(75)38(22-30-25-60-33-14-6-5-13-32(30)33)66-44(73)36(17-10-20-59-50(54)55)64-45(74)37(21-29-11-3-2-4-12-29)65-47(76)39(67-48(40)77)23-31-26-56-27-61-31/h2-6,11-14,25-27,34-40,60H,7-10,15-24H2,1H3,(H2,51,71)(H,56,61)(H,57,70)(H,62,69)(H,63,75)(H,64,74)(H,65,76)(H,66,73)(H,67,77)(H,68,72)(H4,52,53,58)(H4,54,55,59)/t34-,35-,36-,37+,38-,39-,40-/m0/s1
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22n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135673
PNG
(US8846601, 58 | US9458201, 58)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCN)NC1=O)C(O)=O
Show InChI InChI=1S/C49H72N16O10/c1-28(66)59-33(18-10-22-56-48(51)52)41(68)65-39-26-40(67)55-21-8-7-16-36(47(74)75)62-45(72)38(25-30-27-58-32-15-6-5-14-31(30)32)64-43(70)35(19-11-23-57-49(53)54)61-44(71)37(24-29-12-3-2-4-13-29)63-42(69)34(17-9-20-50)60-46(39)73/h2-6,12-15,27,33-39,58H,7-11,16-26,50H2,1H3,(H,55,67)(H,59,66)(H,60,73)(H,61,71)(H,62,72)(H,63,69)(H,64,70)(H,65,68)(H,74,75)(H4,51,52,56)(H4,53,54,57)/t33-,34-,35-,36-,37+,38-,39-/m0/s1
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23n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135663
PNG
(US8846601, 48 | US9458201, 48)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2C(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C54H73N17O10/c1-30(72)65-38(20-11-23-62-53(57)58)47(76)71-43-28-44(73)61-22-10-9-19-37(46(56)75)66-50(79)42(27-33-29-64-36-18-8-7-16-34(33)36)69-48(77)39(21-12-24-63-54(59)60)67-49(78)40(25-31-13-3-2-4-14-31)68-51(80)41(70-52(43)81)26-32-15-5-6-17-35(32)45(55)74/h2-8,13-18,29,37-43,64H,9-12,19-28H2,1H3,(H2,55,74)(H2,56,75)(H,61,73)(H,65,72)(H,66,79)(H,67,78)(H,68,80)(H,69,77)(H,70,81)(H,71,76)(H4,57,58,62)(H4,59,60,63)/t37-,38-,39-,40+,41-,42-,43-/m0/s1
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23n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135631
PNG
(US8846601, 16 | US9458201, 16)
Show SMILES CC(C)C1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O
Show InChI InChI=1S/C49H72N16O9/c1-27(2)40-47(74)64-36(23-29-13-5-4-6-14-29)44(71)61-35(19-12-22-57-49(53)54)43(70)62-37(24-30-26-58-32-16-8-7-15-31(30)32)45(72)60-33(41(50)68)17-9-10-20-55-39(67)25-38(46(73)65-40)63-42(69)34(59-28(3)66)18-11-21-56-48(51)52/h4-8,13-16,26-27,33-38,40,58H,9-12,17-25H2,1-3H3,(H2,50,68)(H,55,67)(H,59,66)(H,60,72)(H,61,71)(H,62,70)(H,63,69)(H,64,74)(H,65,73)(H4,51,52,56)(H4,53,54,57)/t33-,34-,35-,36+,37-,38-,40?/m0/s1
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23n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


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More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135740
PNG
(US8846601, 125 | US9458201, 125)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](Cc3ccc(Cl)cc3)CN2C1=O)C(N)=O
Show InChI InChI=1S/C56H75ClN16O9/c1-32(74)67-41(16-9-23-64-55(59)60)49(77)72-45-29-47(75)63-22-8-7-15-40(48(58)76)68-52(80)44(28-36-30-66-39-14-6-5-13-38(36)39)70-50(78)42(17-10-24-65-56(61)62)69-51(79)43(26-33-11-3-2-4-12-33)71-53(81)46-27-35(31-73(46)54(45)82)25-34-18-20-37(57)21-19-34/h2-6,11-14,18-21,30,35,40-46,66H,7-10,15-17,22-29,31H2,1H3,(H2,58,76)(H,63,75)(H,67,74)(H,68,80)(H,69,79)(H,70,78)(H,71,81)(H,72,77)(H4,59,60,64)(H4,61,62,65)/t35-,40+,41+,42+,43-,44+,45+,46+/m1/s1
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24n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135745
PNG
(US8846601, 130 | US9458201, 130)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCN)NC1=O)C(O)=O
Show InChI InChI=1S/C48H70N16O10/c1-27(65)58-32(14-8-22-55-47(50)51)40(67)59-33-15-7-21-54-39(66)18-17-36(46(73)74)62-45(72)38(25-29-26-57-31-13-6-5-12-30(29)31)64-42(69)34(16-9-23-56-48(52)53)60-44(71)37(24-28-10-3-2-4-11-28)63-43(70)35(19-20-49)61-41(33)68/h2-6,10-13,26,32-38,57H,7-9,14-25,49H2,1H3,(H,54,66)(H,58,65)(H,59,67)(H,60,71)(H,61,68)(H,62,72)(H,63,70)(H,64,69)(H,73,74)(H4,50,51,55)(H4,52,53,56)/t32-,33-,34-,35-,36-,37+,38-/m0/s1
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25n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135723
PNG
(US8846601, 108 | US9458201, 108)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC1=O)C(=O)NC1CC1
Show InChI InChI=1S/C52H75N17O10/c1-29(70)62-35(14-8-24-59-51(54)55)45(74)67-39-20-22-43(72)58-23-7-15-36(44(73)63-32-17-18-32)64-50(79)41(27-31-28-61-34-13-6-5-12-33(31)34)69-46(75)37(16-9-25-60-52(56)57)65-49(78)40(26-30-10-3-2-4-11-30)68-48(77)38(66-47(39)76)19-21-42(53)71/h2-6,10-13,28,32,35-41,61H,7-9,14-27H2,1H3,(H2,53,71)(H,58,72)(H,62,70)(H,63,73)(H,64,79)(H,65,78)(H,66,76)(H,67,74)(H,68,77)(H,69,75)(H4,54,55,59)(H4,56,57,60)/t35-,36-,37-,38-,39-,40+,41-/m0/s1
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26n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135771
PNG
(US8846601, 156 | US9458201, 156)
Show SMILES CC(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C48H69N17O10/c1-26(66)59-32(14-8-20-56-47(51)52)41(70)61-33-15-7-19-55-39(68)18-17-31(40(50)69)60-45(74)36(23-28-25-58-30-13-6-5-12-29(28)30)64-42(71)34(16-9-21-57-48(53)54)62-44(73)35(22-27-10-3-2-4-11-27)63-46(75)37(24-38(49)67)65-43(33)72/h2-6,10-13,25,31-37,58H,7-9,14-24H2,1H3,(H2,49,67)(H2,50,69)(H,55,68)(H,59,66)(H,60,74)(H,61,70)(H,62,73)(H,63,75)(H,64,71)(H,65,72)(H4,51,52,56)(H4,53,54,57)/t31-,32+,33-,34-,35+,36-,37-/m0/s1
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28n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135628
PNG
(US8846601, 13 | US9458201, 13)
Show SMILES CCCC[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O
Show InChI InChI=1S/C50H74N16O9/c1-3-4-17-36-44(71)64-38(25-30-14-6-5-7-15-30)46(73)63-37(21-13-24-58-50(54)55)45(72)65-39(26-31-28-59-33-18-9-8-16-32(31)33)47(74)61-34(42(51)69)19-10-11-22-56-41(68)27-40(48(75)62-36)66-43(70)35(60-29(2)67)20-12-23-57-49(52)53/h5-9,14-16,18,28,34-40,59H,3-4,10-13,17,19-27H2,1-2H3,(H2,51,69)(H,56,68)(H,60,67)(H,61,74)(H,62,75)(H,63,73)(H,64,71)(H,65,72)(H,66,70)(H4,52,53,57)(H4,54,55,58)/t34-,35-,36-,37-,38+,39-,40-/m0/s1
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30n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135665
PNG
(US8846601, 50 | US9458201, 50)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)C(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C54H73N17O10/c1-30(72)65-38(16-9-23-62-53(57)58)47(76)71-43-28-44(73)61-22-8-7-15-37(46(56)75)66-51(80)42(27-34-29-64-36-14-6-5-13-35(34)36)70-48(77)39(17-10-24-63-54(59)60)67-49(78)40(25-31-11-3-2-4-12-31)68-50(79)41(69-52(43)81)26-32-18-20-33(21-19-32)45(55)74/h2-6,11-14,18-21,29,37-43,64H,7-10,15-17,22-28H2,1H3,(H2,55,74)(H2,56,75)(H,61,73)(H,65,72)(H,66,80)(H,67,78)(H,68,79)(H,69,81)(H,70,77)(H,71,76)(H4,57,58,62)(H4,59,60,63)/t37-,38-,39-,40+,41-,42-,43-/m0/s1
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30n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM253654
PNG
(US9458201, 134)
Show SMILES N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](COCc2ccccc2)NC1=O)C(O)=O
Show InChI InChI=1S/C52H71N15O10/c53-35(18-11-23-59-51(54)55)44(69)64-41-27-43(68)58-22-10-9-20-38(50(75)76)63-47(72)40(26-33-28-61-36-19-8-7-17-34(33)36)66-45(70)37(21-12-24-60-52(56)57)62-46(71)39(25-31-13-3-1-4-14-31)65-49(74)42(67-48(41)73)30-77-29-32-15-5-2-6-16-32/h1-8,13-17,19,28,35,37-42,61H,9-12,18,20-27,29-30,53H2,(H,58,68)(H,62,71)(H,63,72)(H,64,69)(H,65,74)(H,66,70)(H,67,73)(H,75,76)(H4,54,55,59)(H4,56,57,60)/t35-,37-,38-,39+,40-,41-,42-/m0/s1
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30n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135617
PNG
(US8846601, 116 | US8846601, 2 | US9458201, 116)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCCN)NC1=O)C(N)=O
Show InChI InChI=1S/C50H75N17O9/c1-29(68)61-35(19-11-23-58-49(53)54)43(71)67-40-27-41(69)57-22-10-8-17-34(42(52)70)62-47(75)39(26-31-28-60-33-16-6-5-15-32(31)33)66-45(73)37(20-12-24-59-50(55)56)64-46(74)38(25-30-13-3-2-4-14-30)65-44(72)36(63-48(40)76)18-7-9-21-51/h2-6,13-16,28,34-40,60H,7-12,17-27,51H2,1H3,(H2,52,70)(H,57,69)(H,61,68)(H,62,75)(H,63,76)(H,64,74)(H,65,72)(H,66,73)(H,67,71)(H4,53,54,58)(H4,55,56,59)/t34-,35-,36-,37-,38+,39-,40-/m0/s1
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30n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135644
PNG
(US8846601, 29 | US9458201, 29)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C48H69N17O10/c1-26(66)59-32(16-9-19-56-47(51)52)41(70)65-37-24-39(68)55-18-8-7-15-31(40(50)69)60-44(73)35(22-28-25-58-30-14-6-5-13-29(28)30)63-42(71)33(17-10-20-57-48(53)54)61-43(72)34(21-27-11-3-2-4-12-27)62-45(74)36(23-38(49)67)64-46(37)75/h2-6,11-14,25,31-37,58H,7-10,15-24H2,1H3,(H2,49,67)(H2,50,69)(H,55,68)(H,59,66)(H,60,73)(H,61,72)(H,62,74)(H,63,71)(H,64,75)(H,65,70)(H4,51,52,56)(H4,53,54,57)/t31-,32-,33-,34+,35-,36-,37-/m0/s1
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32n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM253647
PNG
(US9458201, 93)
Show SMILES CC(=O)NCC[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O
Show InChI InChI=1S/C50H73N17O10/c1-28(68)56-23-19-37-45(74)65-38(24-30-12-4-3-5-13-30)46(75)63-36(18-11-22-59-50(54)55)44(73)66-39(25-31-27-60-33-15-7-6-14-32(31)33)47(76)62-34(42(51)71)16-8-9-20-57-41(70)26-40(48(77)64-37)67-43(72)35(61-29(2)69)17-10-21-58-49(52)53/h3-7,12-15,27,34-40,60H,8-11,16-26H2,1-2H3,(H2,51,71)(H,56,68)(H,57,70)(H,61,69)(H,62,76)(H,63,75)(H,64,77)(H,65,74)(H,66,73)(H,67,72)(H4,52,53,58)(H4,54,55,59)/t34-,35-,36-,37-,38+,39-,40-/m0/s1
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33n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135627
PNG
(US8846601, 12 | US9458201, 12)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O
Show InChI InChI=1S/C50H74N16O9/c1-28(2)23-37-45(72)64-38(24-30-13-5-4-6-14-30)46(73)62-36(19-12-22-58-50(54)55)44(71)65-39(25-31-27-59-33-16-8-7-15-32(31)33)47(74)61-34(42(51)69)17-9-10-20-56-41(68)26-40(48(75)63-37)66-43(70)35(60-29(3)67)18-11-21-57-49(52)53/h4-8,13-16,27-28,34-40,59H,9-12,17-26H2,1-3H3,(H2,51,69)(H,56,68)(H,60,67)(H,61,74)(H,62,73)(H,63,75)(H,64,72)(H,65,71)(H,66,70)(H4,52,53,57)(H4,54,55,58)/t34-,35-,36-,37-,38+,39-,40-/m0/s1
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33n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135722
PNG
(US8846601, 107 | US9458201, 107)
Show SMILES CCNC(=O)[C@@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1
Show InChI InChI=1S/C51H75N17O10/c1-3-57-43(72)34-16-9-23-58-42(71)22-20-38(66-44(73)35(62-29(2)69)17-10-24-59-50(53)54)46(75)65-37(19-21-41(52)70)47(76)67-39(26-30-12-5-4-6-13-30)48(77)64-36(18-11-25-60-51(55)56)45(74)68-40(49(78)63-34)27-31-28-61-33-15-8-7-14-32(31)33/h4-8,12-15,28,34-40,61H,3,9-11,16-27H2,1-2H3,(H2,52,70)(H,57,72)(H,58,71)(H,62,69)(H,63,78)(H,64,77)(H,65,75)(H,66,73)(H,67,76)(H,68,74)(H4,53,54,59)(H4,55,56,60)/t34-,35-,36-,37-,38-,39+,40-/m0/s1
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34n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135746
PNG
(US8846601, 131 | US9458201, 131)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCN)NC1=O)C(O)=O
Show InChI InChI=1S/C48H70N16O10/c1-27(65)58-32(16-9-21-55-47(50)51)40(67)59-33-15-7-8-20-54-39(66)25-38(46(73)74)64-45(72)37(24-29-26-57-31-14-6-5-13-30(29)31)63-42(69)34(17-10-22-56-48(52)53)60-44(71)36(23-28-11-3-2-4-12-28)62-43(70)35(18-19-49)61-41(33)68/h2-6,11-14,26,32-38,57H,7-10,15-25,49H2,1H3,(H,54,66)(H,58,65)(H,59,67)(H,60,71)(H,61,68)(H,62,70)(H,63,69)(H,64,72)(H,73,74)(H4,50,51,55)(H4,52,53,56)/t32-,33-,34-,35-,36+,37-,38-/m0/s1
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35n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135653
PNG
(US8846601, 38 | US9458201, 38)
Show SMILES CSCC[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O
Show InChI InChI=1S/C49H72N16O9S/c1-28(66)59-34(17-10-21-56-48(51)52)42(69)65-39-26-40(67)55-20-9-8-16-33(41(50)68)60-46(73)38(25-30-27-58-32-15-7-6-14-31(30)32)64-43(70)35(18-11-22-57-49(53)54)61-45(72)37(24-29-12-4-3-5-13-29)63-44(71)36(19-23-75-2)62-47(39)74/h3-7,12-15,27,33-39,58H,8-11,16-26H2,1-2H3,(H2,50,68)(H,55,67)(H,59,66)(H,60,73)(H,61,72)(H,62,74)(H,63,71)(H,64,70)(H,65,69)(H4,51,52,56)(H4,53,54,57)/t33-,34-,35-,36-,37+,38-,39-/m0/s1
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35n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135744
PNG
(US8846601, 129 | US9458201, 136)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCNC(=O)CCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCN)NC1=O)C(N)=O
Show InChI InChI=1S/C48H71N17O9/c1-27(66)59-33(15-8-21-56-47(51)52)41(69)63-36-19-23-55-39(67)17-7-14-32(40(50)68)60-46(74)38(25-29-26-58-31-13-6-5-12-30(29)31)65-42(70)34(16-9-22-57-48(53)54)61-45(73)37(24-28-10-3-2-4-11-28)64-43(71)35(18-20-49)62-44(36)72/h2-6,10-13,26,32-38,58H,7-9,14-25,49H2,1H3,(H2,50,68)(H,55,67)(H,59,66)(H,60,74)(H,61,73)(H,62,72)(H,63,69)(H,64,71)(H,65,70)(H4,51,52,56)(H4,53,54,57)/t32-,33-,34-,35-,36-,37+,38-/m0/s1
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35n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135651
PNG
(US8846601, 36 | US9458201, 36)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O)C(N)=O
Show InChI InChI=1S/C55H73N17O9/c1-31(73)66-40(20-11-23-62-54(57)58)48(76)72-45-28-46(74)61-22-10-9-19-39(47(56)75)67-51(79)43(26-33-29-64-37-17-7-5-15-35(33)37)70-49(77)41(21-12-24-63-55(59)60)68-50(78)42(25-32-13-3-2-4-14-32)69-52(80)44(71-53(45)81)27-34-30-65-38-18-8-6-16-36(34)38/h2-8,13-18,29-30,39-45,64-65H,9-12,19-28H2,1H3,(H2,56,75)(H,61,74)(H,66,73)(H,67,79)(H,68,78)(H,69,80)(H,70,77)(H,71,81)(H,72,76)(H4,57,58,62)(H4,59,60,63)/t39-,40-,41-,42+,43-,44-,45-/m0/s1
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37n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135703
PNG
(US8846601, 88 | US9458201, 88)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC1=O)C(O)=O
Show InChI InChI=1S/C50H74N18O10/c1-28(69)62-33(15-7-22-58-48(51)52)41(71)65-36-19-20-40(70)57-21-10-18-37(47(77)78)66-46(76)39(26-30-27-61-32-14-6-5-13-31(30)32)68-43(73)35(17-9-24-60-50(55)56)64-45(75)38(25-29-11-3-2-4-12-29)67-42(72)34(63-44(36)74)16-8-23-59-49(53)54/h2-6,11-14,27,33-39,61H,7-10,15-26H2,1H3,(H,57,70)(H,62,69)(H,63,74)(H,64,75)(H,65,71)(H,66,76)(H,67,72)(H,68,73)(H,77,78)(H4,51,52,58)(H4,53,54,59)(H4,55,56,60)/t33-,34-,35-,36-,37-,38+,39-/m0/s1
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37n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135700
PNG
(US8846601, 85 | US9458201, 85)
Show SMILES CC(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(O)=O
Show InChI InChI=1S/C50H69N17O10/c1-28(68)61-34(14-7-20-57-49(51)52)42(70)63-36-17-18-41(69)56-19-9-16-37(48(76)77)64-46(74)39(23-30-25-59-33-13-6-5-12-32(30)33)66-43(71)35(15-8-21-58-50(53)54)62-45(73)38(22-29-10-3-2-4-11-29)65-47(75)40(67-44(36)72)24-31-26-55-27-60-31/h2-6,10-13,25-27,34-40,59H,7-9,14-24H2,1H3,(H,55,60)(H,56,69)(H,61,68)(H,62,73)(H,63,70)(H,64,74)(H,65,75)(H,66,71)(H,67,72)(H,76,77)(H4,51,52,57)(H4,53,54,58)/t34-,35+,36+,37+,38-,39+,40+/m1/s1
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40n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135772
PNG
(US8846601, 157 | US9458201, 157)
Show SMILES N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C46H67N17O9/c47-28(12-6-19-55-45(50)51)39(67)59-31-14-7-18-54-37(65)17-16-30(38(49)66)58-43(71)34(22-26-24-57-29-13-5-4-11-27(26)29)62-41(69)32(15-8-20-56-46(52)53)60-42(70)33(21-25-9-2-1-3-10-25)61-44(72)35(23-36(48)64)63-40(31)68/h1-5,9-11,13,24,28,30-35,57H,6-8,12,14-23,47H2,(H2,48,64)(H2,49,66)(H,54,65)(H,58,71)(H,59,67)(H,60,70)(H,61,72)(H,62,69)(H,63,68)(H4,50,51,55)(H4,52,53,56)/t28-,30-,31-,32-,33+,34-,35-/m0/s1
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42n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135696
PNG
(US8846601, 81 | US9458201, 81)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC1=O)C(O)=O
Show InChI InChI=1S/C49H70N16O11/c1-27(66)59-32(14-7-22-56-48(51)52)41(69)62-35-18-20-40(68)55-21-9-16-36(47(75)76)63-46(74)38(25-29-26-58-31-13-6-5-12-30(29)31)65-42(70)33(15-8-23-57-49(53)54)60-45(73)37(24-28-10-3-2-4-11-28)64-44(72)34(61-43(35)71)17-19-39(50)67/h2-6,10-13,26,32-38,58H,7-9,14-25H2,1H3,(H2,50,67)(H,55,68)(H,59,66)(H,60,73)(H,61,71)(H,62,69)(H,63,74)(H,64,72)(H,65,70)(H,75,76)(H4,51,52,56)(H4,53,54,57)/t32-,33-,34-,35-,36-,37+,38-/m0/s1
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43n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135626
PNG
(US8846601, 11 | US9458201, 11)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O)C(N)=O
Show InChI InChI=1S/C53H72N16O10/c1-30(70)63-38(16-9-23-60-52(55)56)46(74)69-43-28-44(72)59-22-8-7-15-37(45(54)73)64-50(78)42(27-33-29-62-36-14-6-5-13-35(33)36)68-47(75)39(17-10-24-61-53(57)58)65-48(76)40(25-31-11-3-2-4-12-31)66-49(77)41(67-51(43)79)26-32-18-20-34(71)21-19-32/h2-6,11-14,18-21,29,37-43,62,71H,7-10,15-17,22-28H2,1H3,(H2,54,73)(H,59,72)(H,63,70)(H,64,78)(H,65,76)(H,66,77)(H,67,79)(H,68,75)(H,69,74)(H4,55,56,60)(H4,57,58,61)/t37-,38-,39-,40+,41-,42-,43-/m0/s1
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43n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135686
PNG
(US8846601, 71 | US9458201, 71)
Show SMILES CC(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C49H71N17O10/c1-27(67)60-33(16-9-21-57-48(52)53)42(71)66-38-25-40(69)56-20-8-7-15-32(41(51)70)61-46(75)37(24-29-26-59-31-14-6-5-13-30(29)31)65-43(72)34(17-10-22-58-49(54)55)62-45(74)36(23-28-11-3-2-4-12-28)64-44(73)35(63-47(38)76)18-19-39(50)68/h2-6,11-14,26,32-38,59H,7-10,15-25H2,1H3,(H2,50,68)(H2,51,70)(H,56,69)(H,60,67)(H,61,75)(H,62,74)(H,63,76)(H,64,73)(H,65,72)(H,66,71)(H4,52,53,57)(H4,54,55,58)/t32-,33+,34-,35-,36+,37-,38-/m0/s1
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45n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135759
PNG
(US8846601, 144 | US9458201, 144)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCC(=O)NCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCN)NC1=O)C(O)=O
Show InChI InChI=1S/C48H70N16O10/c1-27(65)58-32(15-8-21-55-47(50)51)40(67)59-33-14-7-17-39(66)54-23-19-36(46(73)74)62-45(72)38(25-29-26-57-31-13-6-5-12-30(29)31)64-42(69)34(16-9-22-56-48(52)53)60-44(71)37(24-28-10-3-2-4-11-28)63-43(70)35(18-20-49)61-41(33)68/h2-6,10-13,26,32-38,57H,7-9,14-25,49H2,1H3,(H,54,66)(H,58,65)(H,59,67)(H,60,71)(H,61,68)(H,62,72)(H,63,70)(H,64,69)(H,73,74)(H4,50,51,55)(H4,52,53,56)/t32-,33-,34-,35-,36-,37+,38-/m0/s1
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45n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135685
PNG
(US8846601, 70 | US9458201, 70)
Show SMILES C[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@@H](CCCNC(N)=N)NC(C)=O
Show InChI InChI=1S/C47H68N16O9/c1-26-40(67)61-35(22-28-12-4-3-5-13-28)44(71)60-34(18-11-21-55-47(51)52)42(69)62-36(23-29-25-56-31-15-7-6-14-30(29)31)45(72)59-32(39(48)66)16-8-9-19-53-38(65)24-37(43(70)57-26)63-41(68)33(58-27(2)64)17-10-20-54-46(49)50/h3-7,12-15,25-26,32-37,56H,8-11,16-24H2,1-2H3,(H2,48,66)(H,53,65)(H,57,70)(H,58,64)(H,59,72)(H,60,71)(H,61,67)(H,62,69)(H,63,68)(H4,49,50,54)(H4,51,52,55)/t26-,32-,33+,34-,35+,36-,37-/m0/s1
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46n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135675
PNG
(US8846601, 60 | US9458201, 60)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@](C)(Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O
Show InChI InChI=1S/C51H72N18O9/c1-29(70)63-36(17-10-20-59-49(53)54)43(73)67-40-24-41(71)58-19-9-8-16-35(42(52)72)64-45(75)38(22-31-26-61-34-15-7-6-14-33(31)34)65-44(74)37(18-11-21-60-50(55)56)68-48(78)51(2,25-30-12-4-3-5-13-30)69-47(77)39(66-46(40)76)23-32-27-57-28-62-32/h3-7,12-15,26-28,35-40,61H,8-11,16-25H2,1-2H3,(H2,52,72)(H,57,62)(H,58,71)(H,63,70)(H,64,75)(H,65,74)(H,66,76)(H,67,73)(H,68,78)(H,69,77)(H4,53,54,59)(H4,55,56,60)/t35-,36-,37-,38-,39-,40-,51+/m0/s1
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47n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135773
PNG
(US8846601, 158 | US9458201, 158)
Show SMILES CC(=O)N[C@@H](CCCN)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C47H67N15O10/c1-26(63)56-32(14-7-19-48)41(67)58-33-15-8-20-53-39(65)18-17-31(40(50)66)57-45(71)36(23-28-25-55-30-13-6-5-12-29(28)30)61-42(68)34(16-9-21-54-47(51)52)59-44(70)35(22-27-10-3-2-4-11-27)60-46(72)37(24-38(49)64)62-43(33)69/h2-6,10-13,25,31-37,55H,7-9,14-24,48H2,1H3,(H2,49,64)(H2,50,66)(H,53,65)(H,56,63)(H,57,71)(H,58,67)(H,59,70)(H,60,72)(H,61,68)(H,62,69)(H4,51,52,54)/t31-,32-,33-,34-,35+,36-,37-/m0/s1
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50n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


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More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135625
PNG
(US8846601, 10 | US9458201, 10)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC1=O)C(N)=O
Show InChI InChI=1S/C53H72N16O9/c1-31(70)63-38(21-12-24-60-52(55)56)46(73)69-43-29-44(71)59-23-11-10-20-37(45(54)72)64-50(77)42(28-34-30-62-36-19-9-8-18-35(34)36)68-47(74)39(22-13-25-61-53(57)58)65-48(75)40(26-32-14-4-2-5-15-32)66-49(76)41(67-51(43)78)27-33-16-6-3-7-17-33/h2-9,14-19,30,37-43,62H,10-13,20-29H2,1H3,(H2,54,72)(H,59,71)(H,63,70)(H,64,77)(H,65,75)(H,66,76)(H,67,78)(H,68,74)(H,69,73)(H4,55,56,60)(H4,57,58,61)/t37-,38-,39-,40+,41-,42-,43-/m0/s1
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51n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135688
PNG
(US8846601, 73 | US9458201, 73)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC1=O)C(O)=O
Show InChI InChI=1S/C50H74N18O10/c1-28(69)62-33(17-9-21-58-48(51)52)41(71)68-39-26-40(70)57-20-8-7-16-36(47(77)78)65-45(75)38(25-30-27-61-32-15-6-5-14-31(30)32)67-43(73)35(19-11-23-60-50(55)56)63-44(74)37(24-29-12-3-2-4-13-29)66-42(72)34(64-46(39)76)18-10-22-59-49(53)54/h2-6,12-15,27,33-39,61H,7-11,16-26H2,1H3,(H,57,70)(H,62,69)(H,63,74)(H,64,76)(H,65,75)(H,66,72)(H,67,73)(H,68,71)(H,77,78)(H4,51,52,58)(H4,53,54,59)(H4,55,56,60)/t33-,34-,35-,36-,37+,38-,39-/m0/s1
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60n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135721
PNG
(US8846601, 106 | US9458201, 106)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC1=O)C(=O)NC1CC1
Show InChI InChI=1S/C52H75N17O10/c1-29(70)62-35(16-9-23-59-51(54)55)45(74)69-41-27-43(72)58-22-8-7-15-36(44(73)63-32-18-19-32)64-49(78)40(26-31-28-61-34-14-6-5-13-33(31)34)68-46(75)37(17-10-24-60-52(56)57)65-48(77)39(25-30-11-3-2-4-12-30)67-47(76)38(66-50(41)79)20-21-42(53)71/h2-6,11-14,28,32,35-41,61H,7-10,15-27H2,1H3,(H2,53,71)(H,58,72)(H,62,70)(H,63,73)(H,64,78)(H,65,77)(H,66,79)(H,67,76)(H,68,75)(H,69,74)(H4,54,55,59)(H4,56,57,60)/t35-,36-,37-,38-,39+,40-,41-/m0/s1
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64n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135701
PNG
(US8846601, 86 | US9458201, 86)
Show SMILES CC(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC1=O)C(O)=O
Show InChI InChI=1S/C49H70N16O11/c1-27(66)59-32(14-7-22-56-48(51)52)41(69)62-35-18-20-40(68)55-21-9-16-36(47(75)76)63-46(74)38(25-29-26-58-31-13-6-5-12-30(29)31)65-42(70)33(15-8-23-57-49(53)54)60-45(73)37(24-28-10-3-2-4-11-28)64-44(72)34(61-43(35)71)17-19-39(50)67/h2-6,10-13,26,32-38,58H,7-9,14-25H2,1H3,(H2,50,67)(H,55,68)(H,59,66)(H,60,73)(H,61,71)(H,62,69)(H,63,74)(H,64,72)(H,65,70)(H,75,76)(H4,51,52,56)(H4,53,54,57)/t32-,33+,34+,35+,36+,37-,38+/m1/s1
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66n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135677
PNG
(US8846601, 62 | US9458201, 62)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CN)NC1=O)C(N)=O
Show InChI InChI=1S/C47H69N17O9/c1-26(65)58-32(16-9-19-55-46(50)51)40(68)63-36-23-38(66)54-18-8-7-15-31(39(49)67)59-43(71)35(22-28-25-57-30-14-6-5-13-29(28)30)62-41(69)33(17-10-20-56-47(52)53)60-42(70)34(21-27-11-3-2-4-12-27)61-45(73)37(24-48)64-44(36)72/h2-6,11-14,25,31-37,57H,7-10,15-24,48H2,1H3,(H2,49,67)(H,54,66)(H,58,65)(H,59,71)(H,60,70)(H,61,73)(H,62,69)(H,63,68)(H,64,72)(H4,50,51,55)(H4,52,53,56)/t31-,32-,33-,34+,35-,36-,37-/m0/s1
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80n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135693
PNG
(US8846601, 78 | US9458201, 78)
Show SMILES N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C47H69N17O9/c48-29(13-8-20-56-46(51)52)40(68)62-36-24-38(66)55-19-7-6-15-31(39(50)67)59-44(72)35(23-27-25-58-30-14-5-4-12-28(27)30)64-41(69)32(16-9-21-57-47(53)54)60-43(71)34(22-26-10-2-1-3-11-26)63-42(70)33(61-45(36)73)17-18-37(49)65/h1-5,10-12,14,25,29,31-36,58H,6-9,13,15-24,48H2,(H2,49,65)(H2,50,67)(H,55,66)(H,59,72)(H,60,71)(H,61,73)(H,62,68)(H,63,70)(H,64,69)(H4,51,52,56)(H4,53,54,57)/t29-,31-,32-,33-,34+,35-,36-/m0/s1
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86n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135616
PNG
(US8846601, 1 | US8846601, 115 | US8846601, 51 | US...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O
Show InChI InChI=1S/C50H70N18O9/c1-28(69)62-35(16-9-19-58-49(52)53)43(72)68-40-24-41(70)57-18-8-7-15-34(42(51)71)63-46(75)38(22-30-25-60-33-14-6-5-13-32(30)33)66-44(73)36(17-10-20-59-50(54)55)64-45(74)37(21-29-11-3-2-4-12-29)65-47(76)39(67-48(40)77)23-31-26-56-27-61-31/h2-6,11-14,25-27,34-40,60H,7-10,15-24H2,1H3,(H2,51,71)(H,56,61)(H,57,70)(H,62,69)(H,63,75)(H,64,74)(H,65,76)(H,66,73)(H,67,77)(H,68,72)(H4,52,53,58)(H4,54,55,59)/t34-,35-,36-,37+,38-,39-,40-/m0/s1
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87n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135729
PNG
(US8846601, 114 | US9458201, 114)
Show SMILES CC(=O)NC[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O
Show InChI InChI=1S/C49H71N17O10/c1-27(67)58-26-39-47(76)63-36(22-29-12-4-3-5-13-29)44(73)62-35(18-11-21-57-49(53)54)43(72)64-37(23-30-25-59-32-15-7-6-14-31(30)32)45(74)61-33(41(50)70)16-8-9-19-55-40(69)24-38(46(75)66-39)65-42(71)34(60-28(2)68)17-10-20-56-48(51)52/h3-7,12-15,25,33-39,59H,8-11,16-24,26H2,1-2H3,(H2,50,70)(H,55,69)(H,58,67)(H,60,68)(H,61,74)(H,62,73)(H,63,76)(H,64,72)(H,65,71)(H,66,75)(H4,51,52,56)(H4,53,54,57)/t33-,34-,35-,36+,37-,38-,39-/m0/s1
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88n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135656
PNG
(US8846601, 41 | US9458201, 41)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]cn2)NC1=O)C(N)=O
Show InChI InChI=1S/C50H70N18O9/c1-28(69)62-35(16-9-19-58-49(52)53)43(72)68-40-24-41(70)57-18-8-7-15-34(42(51)71)63-46(75)38(22-30-25-60-33-14-6-5-13-32(30)33)66-44(73)36(17-10-20-59-50(54)55)64-45(74)37(21-29-11-3-2-4-12-29)65-47(76)39(67-48(40)77)23-31-26-56-27-61-31/h2-6,11-14,25-27,34-40,60H,7-10,15-24H2,1H3,(H2,51,71)(H,56,61)(H,57,70)(H,62,69)(H,63,75)(H,64,74)(H,65,76)(H,66,73)(H,67,77)(H,68,72)(H4,52,53,58)(H4,54,55,59)/t34-,35-,36-,37+,38-,39+,40-/m0/s1
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95n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135671
PNG
(US8846601, 56 | US9458201, 56)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(O)=O
Show InChI InChI=1S/C48H68N16O11/c1-26(65)58-31(16-9-19-55-47(50)51)40(68)64-37-24-39(67)54-18-8-7-15-33(46(74)75)60-43(71)35(22-28-25-57-30-14-6-5-13-29(28)30)62-41(69)32(17-10-20-56-48(52)53)59-42(70)34(21-27-11-3-2-4-12-27)61-44(72)36(23-38(49)66)63-45(37)73/h2-6,11-14,25,31-37,57H,7-10,15-24H2,1H3,(H2,49,66)(H,54,67)(H,58,65)(H,59,70)(H,60,71)(H,61,72)(H,62,69)(H,63,73)(H,64,68)(H,74,75)(H4,50,51,55)(H4,52,53,56)/t31-,32-,33-,34+,35-,36-,37-/m0/s1
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100n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM253648
PNG
(US9458201, 94)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCNC(=O)CN)NC1=O)C(N)=O
Show InChI InChI=1S/C50H74N18O10/c1-28(69)62-34(16-9-20-59-49(53)54)43(73)68-39-25-40(70)57-19-8-7-15-33(42(52)72)63-47(77)38(24-30-27-61-32-14-6-5-13-31(30)32)67-44(74)35(17-10-21-60-50(55)56)64-46(76)37(23-29-11-3-2-4-12-29)66-45(75)36(65-48(39)78)18-22-58-41(71)26-51/h2-6,11-14,27,33-39,61H,7-10,15-26,51H2,1H3,(H2,52,72)(H,57,70)(H,58,71)(H,62,69)(H,63,77)(H,64,76)(H,65,78)(H,66,75)(H,67,74)(H,68,73)(H4,53,54,59)(H4,55,56,60)/t33-,34-,35-,36-,37+,38-,39-/m0/s1
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110n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135704
PNG
(US8846601, 89 | US9458201, 89)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCCN)NC1=O)C(O)=O
Show InChI InChI=1S/C50H74N16O10/c1-29(67)60-34(17-9-24-57-49(52)53)42(69)63-37-20-21-41(68)56-23-11-19-38(48(75)76)64-47(74)40(27-31-28-59-33-15-6-5-14-32(31)33)66-44(71)36(18-10-25-58-50(54)55)62-46(73)39(26-30-12-3-2-4-13-30)65-43(70)35(61-45(37)72)16-7-8-22-51/h2-6,12-15,28,34-40,59H,7-11,16-27,51H2,1H3,(H,56,68)(H,60,67)(H,61,72)(H,62,73)(H,63,69)(H,64,74)(H,65,70)(H,66,71)(H,75,76)(H4,52,53,57)(H4,54,55,58)/t34-,35-,36-,37-,38-,39+,40-/m0/s1
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113n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM253639
PNG
(US9458201, 57)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC1=O)C(O)=O
Show InChI InChI=1S/C49H70N16O11/c1-27(66)59-32(16-9-21-56-48(51)52)41(69)65-38-25-40(68)55-20-8-7-15-35(47(75)76)62-45(73)37(24-29-26-58-31-14-6-5-13-30(29)31)64-42(70)33(17-10-22-57-49(53)54)60-44(72)36(23-28-11-3-2-4-12-28)63-43(71)34(61-46(38)74)18-19-39(50)67/h2-6,11-14,26,32-38,58H,7-10,15-25H2,1H3,(H2,50,67)(H,55,68)(H,59,66)(H,60,72)(H,61,74)(H,62,73)(H,63,71)(H,64,70)(H,65,69)(H,75,76)(H4,51,52,56)(H4,53,54,57)/t32-,33-,34-,35-,36+,37-,38-/m0/s1
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115n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


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More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM135767
PNG
(US8846601, 152 | US9458201, 152)
Show SMILES CC(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C49H71N17O10/c1-27(67)60-33(14-8-22-57-48(52)53)42(71)62-34-15-7-21-56-40(69)20-18-32(41(51)70)61-47(76)38(25-29-26-59-31-13-6-5-12-30(29)31)66-44(73)35(16-9-23-58-49(54)55)63-46(75)37(24-28-10-3-2-4-11-28)65-45(74)36(64-43(34)72)17-19-39(50)68/h2-6,10-13,26,32-38,59H,7-9,14-25H2,1H3,(H2,50,68)(H2,51,70)(H,56,69)(H,60,67)(H,61,76)(H,62,71)(H,63,75)(H,64,72)(H,65,74)(H,66,73)(H4,52,53,57)(H4,54,55,58)/t32-,33+,34-,35-,36-,37+,38-/m0/s1
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120n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM135765
PNG
(US8846601, 150 | US9458201, 150)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C49H71N17O10/c1-27(67)60-33(14-8-22-57-48(52)53)42(71)62-34-15-7-21-56-40(69)20-18-32(41(51)70)61-47(76)38(25-29-26-59-31-13-6-5-12-30(29)31)66-44(73)35(16-9-23-58-49(54)55)63-46(75)37(24-28-10-3-2-4-11-28)65-45(74)36(64-43(34)72)17-19-39(50)68/h2-6,10-13,26,32-38,59H,7-9,14-25H2,1H3,(H2,50,68)(H2,51,70)(H,56,69)(H,60,67)(H,61,76)(H,62,71)(H,63,75)(H,64,72)(H,65,74)(H,66,73)(H4,52,53,57)(H4,54,55,58)/t32-,33-,34-,35-,36-,37+,38-/m0/s1
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130n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM135774
PNG
(US8846601, 159 | US9458201, 159)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCNC(=O)CCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C49H71N17O10/c1-27(67)60-33(15-8-21-57-48(52)53)42(71)64-36-20-23-56-40(69)17-7-14-32(41(51)70)61-47(76)38(25-29-26-59-31-13-6-5-12-30(29)31)66-43(72)34(16-9-22-58-49(54)55)62-46(75)37(24-28-10-3-2-4-11-28)65-44(73)35(63-45(36)74)18-19-39(50)68/h2-6,10-13,26,32-38,59H,7-9,14-25H2,1H3,(H2,50,68)(H2,51,70)(H,56,69)(H,60,67)(H,61,76)(H,62,75)(H,63,74)(H,64,71)(H,65,73)(H,66,72)(H4,52,53,57)(H4,54,55,58)/t32-,33-,34-,35-,36-,37+,38-/m0/s1
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133n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135650
PNG
(US8846601, 35 | US9458201, 35)
Show SMILES C[C@@H](O)[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O
Show InChI InChI=1S/C48H70N16O10/c1-26(65)39-46(74)63-35(22-28-12-4-3-5-13-28)43(71)60-34(18-11-21-56-48(52)53)42(70)61-36(23-29-25-57-31-15-7-6-14-30(29)31)44(72)59-32(40(49)68)16-8-9-19-54-38(67)24-37(45(73)64-39)62-41(69)33(58-27(2)66)17-10-20-55-47(50)51/h3-7,12-15,25-26,32-37,39,57,65H,8-11,16-24H2,1-2H3,(H2,49,68)(H,54,67)(H,58,66)(H,59,72)(H,60,71)(H,61,70)(H,62,69)(H,63,74)(H,64,73)(H4,50,51,55)(H4,52,53,56)/t26-,32+,33+,34+,35-,36+,37+,39+/m1/s1
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140n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135624
PNG
(US8846601, 52 | US8846601, 9 | US9458201, 52)
Show SMILES C[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O
Show InChI InChI=1S/C47H68N16O9/c1-26-40(67)61-35(22-28-12-4-3-5-13-28)44(71)60-34(18-11-21-55-47(51)52)42(69)62-36(23-29-25-56-31-15-7-6-14-30(29)31)45(72)59-32(39(48)66)16-8-9-19-53-38(65)24-37(43(70)57-26)63-41(68)33(58-27(2)64)17-10-20-54-46(49)50/h3-7,12-15,25-26,32-37,56H,8-11,16-24H2,1-2H3,(H2,48,66)(H,53,65)(H,57,70)(H,58,64)(H,59,72)(H,60,71)(H,61,67)(H,62,69)(H,63,68)(H4,49,50,54)(H4,51,52,55)/t26-,32-,33-,34-,35+,36-,37-/m0/s1
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144n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135733
PNG
(US8846601, 118 | US9458201, 118)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CNC(=O)[C@H]2CCNC2)NC1=O)C(N)=O
Show InChI InChI=1S/C52H76N18O10/c1-29(71)64-36(16-9-20-60-51(54)55)45(75)69-40-25-42(72)59-19-8-7-15-35(43(53)73)65-48(78)39(24-32-27-62-34-14-6-5-13-33(32)34)68-46(76)37(17-10-21-61-52(56)57)66-47(77)38(23-30-11-3-2-4-12-30)67-50(80)41(70-49(40)79)28-63-44(74)31-18-22-58-26-31/h2-6,11-14,27,31,35-41,58,62H,7-10,15-26,28H2,1H3,(H2,53,73)(H,59,72)(H,63,74)(H,64,71)(H,65,78)(H,66,77)(H,67,80)(H,68,76)(H,69,75)(H,70,79)(H4,54,55,60)(H4,56,57,61)/t31-,35-,36-,37-,38+,39-,40-,41-/m0/s1
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145n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM135776
PNG
(US8846601, 161 | US9458201, 161)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C48H69N17O10/c1-26(66)59-32(15-8-20-56-47(51)52)41(70)62-34-17-18-39(68)55-19-7-14-31(40(50)69)60-45(74)36(23-28-25-58-30-13-6-5-12-29(28)30)64-42(71)33(16-9-21-57-48(53)54)61-44(73)35(22-27-10-3-2-4-11-27)63-46(75)37(24-38(49)67)65-43(34)72/h2-6,10-13,25,31-37,58H,7-9,14-24H2,1H3,(H2,49,67)(H2,50,69)(H,55,68)(H,59,66)(H,60,74)(H,61,73)(H,62,70)(H,63,75)(H,64,71)(H,65,72)(H4,51,52,56)(H4,53,54,57)/t31-,32-,33-,34-,35+,36-,37-/m0/s1
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155n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135706
PNG
(US8846601, 91 | US9458201, 91)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(O)=O
Show InChI InChI=1S/C48H68N16O11/c1-26(65)58-31(14-7-20-55-47(50)51)40(68)60-33-17-18-39(67)54-19-9-16-34(46(74)75)61-44(72)36(23-28-25-57-30-13-6-5-12-29(28)30)63-41(69)32(15-8-21-56-48(52)53)59-43(71)35(22-27-10-3-2-4-11-27)62-45(73)37(24-38(49)66)64-42(33)70/h2-6,10-13,25,31-37,57H,7-9,14-24H2,1H3,(H2,49,66)(H,54,67)(H,58,65)(H,59,71)(H,60,68)(H,61,72)(H,62,73)(H,63,69)(H,64,70)(H,74,75)(H4,50,51,55)(H4,52,53,56)/t31-,32-,33-,34-,35+,36-,37-/m0/s1
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167n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135702
PNG
(US8846601, 87 | US9458201, 87)
Show SMILES CC(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCN)NC1=O)C(O)=O
Show InChI InChI=1S/C48H70N16O10/c1-27(65)58-32(14-7-22-55-47(50)51)40(67)60-34-17-18-39(66)54-21-9-16-36(46(73)74)62-45(72)38(25-29-26-57-31-13-6-5-12-30(29)31)64-41(68)33(15-8-23-56-48(52)53)59-44(71)37(24-28-10-3-2-4-11-28)63-43(70)35(19-20-49)61-42(34)69/h2-6,10-13,26,32-38,57H,7-9,14-25,49H2,1H3,(H,54,66)(H,58,65)(H,59,71)(H,60,67)(H,61,69)(H,62,72)(H,63,70)(H,64,68)(H,73,74)(H4,50,51,55)(H4,52,53,56)/t32-,33+,34+,35+,36+,37-,38+/m1/s1
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171n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135618
PNG
(US8846601, 117 | US8846601, 3 | US9458201, 117)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CO)NC1=O)C(N)=O
Show InChI InChI=1S/C47H68N16O10/c1-26(65)57-32(16-9-19-54-46(49)50)40(68)62-36-23-38(66)53-18-8-7-15-31(39(48)67)58-43(71)35(22-28-24-56-30-14-6-5-13-29(28)30)61-41(69)33(17-10-20-55-47(51)52)59-42(70)34(21-27-11-3-2-4-12-27)60-45(73)37(25-64)63-44(36)72/h2-6,11-14,24,31-37,56,64H,7-10,15-23,25H2,1H3,(H2,48,67)(H,53,66)(H,57,65)(H,58,71)(H,59,70)(H,60,73)(H,61,69)(H,62,68)(H,63,72)(H4,49,50,54)(H4,51,52,55)/t31-,32-,33-,34+,35-,36-,37-/m0/s1
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172n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM253646
PNG
(US9458201, 92)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=O)NC1=O)C(O)=O
Show InChI InChI=1S/C50H73N17O11/c1-28(68)61-33(15-7-22-57-48(51)52)41(70)64-36-19-20-40(69)56-21-10-18-37(47(76)77)65-46(75)39(26-30-27-60-32-14-6-5-13-31(30)32)67-43(72)35(16-8-23-58-49(53)54)63-45(74)38(25-29-11-3-2-4-12-29)66-42(71)34(62-44(36)73)17-9-24-59-50(55)78/h2-6,11-14,27,33-39,60H,7-10,15-26H2,1H3,(H,56,69)(H,61,68)(H,62,73)(H,63,74)(H,64,70)(H,65,75)(H,66,71)(H,67,72)(H,76,77)(H4,51,52,57)(H4,53,54,58)(H3,55,59,78)/t33-,34-,35-,36-,37-,38+,39-/m0/s1
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184n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM253638
PNG
(US9458201, 53)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(O)=O
Show InChI InChI=1S/C50H68N16O11/c1-28(67)60-34(16-9-19-56-49(51)52)42(69)66-40-24-41(68)55-18-8-7-15-36(48(75)76)62-45(72)38(22-30-25-58-33-14-6-5-13-32(30)33)64-43(70)35(17-10-20-57-50(53)77)61-44(71)37(21-29-11-3-2-4-12-29)63-46(73)39(65-47(40)74)23-31-26-54-27-59-31/h2-6,11-14,25-27,34-40,58H,7-10,15-24H2,1H3,(H,54,59)(H,55,68)(H,60,67)(H,61,71)(H,62,72)(H,63,73)(H,64,70)(H,65,74)(H,66,69)(H,75,76)(H4,51,52,56)(H3,53,57,77)/t34-,35-,36-,37+,38-,39-,40-/m0/s1
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214n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM135770
PNG
(US8846601, 155 | US9458201, 155)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C48H69N17O10/c1-26(66)59-31(16-9-19-56-47(51)52)41(70)60-32-15-7-8-18-55-39(68)24-34(40(50)69)62-45(74)36(22-28-25-58-30-14-6-5-13-29(28)30)64-43(72)33(17-10-20-57-48(53)54)61-44(73)35(21-27-11-3-2-4-12-27)63-46(75)37(23-38(49)67)65-42(32)71/h2-6,11-14,25,31-37,58H,7-10,15-24H2,1H3,(H2,49,67)(H2,50,69)(H,55,68)(H,59,66)(H,60,70)(H,61,73)(H,62,74)(H,63,75)(H,64,72)(H,65,71)(H4,51,52,56)(H4,53,54,57)/t31-,32-,33-,34-,35+,36-,37-/m0/s1
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240n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM135777
PNG
(US8846601, 162 | US9458201, 162)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C50H70N16O10/c1-28(67)60-33(16-9-21-58-49(53)54)43(71)61-34-15-7-8-20-57-41(69)27-36(42(52)70)63-47(75)38(25-30-18-19-31-13-5-6-14-32(31)23-30)64-45(73)35(17-10-22-59-50(55)56)62-46(74)37(24-29-11-3-2-4-12-29)65-48(76)39(26-40(51)68)66-44(34)72/h2-6,11-14,18-19,23,33-39H,7-10,15-17,20-22,24-27H2,1H3,(H2,51,68)(H2,52,70)(H,57,69)(H,60,67)(H,61,71)(H,62,74)(H,63,75)(H,64,73)(H,65,76)(H,66,72)(H4,53,54,58)(H4,55,56,59)/t33-,34-,35-,36-,37+,38-,39-/m0/s1
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255n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM135775
PNG
(US8846601, 160 | US9458201, 160)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCC(=O)NCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C48H69N17O10/c1-26(66)59-32(15-8-19-56-47(51)52)41(70)61-33-14-7-17-39(68)55-21-18-31(40(50)69)60-45(74)36(23-28-25-58-30-13-6-5-12-29(28)30)64-43(72)34(16-9-20-57-48(53)54)62-44(73)35(22-27-10-3-2-4-11-27)63-46(75)37(24-38(49)67)65-42(33)71/h2-6,10-13,25,31-37,58H,7-9,14-24H2,1H3,(H2,49,67)(H2,50,69)(H,55,68)(H,59,66)(H,60,74)(H,61,70)(H,62,73)(H,63,75)(H,64,72)(H,65,71)(H4,51,52,56)(H4,53,54,57)/t31-,32-,33-,34-,35+,36-,37-/m0/s1
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295n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135768
PNG
(US8846601, 153 | US9458201, 153)
Show SMILES CCCCC(=O)N[C@H]1CCC(=O)NCC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Show InChI InChI=1S/C46H62N14O8/c1-2-3-15-39(62)55-33-16-17-38(61)51-20-18-34(43(66)58-35(40(47)63)22-28-24-53-31-13-8-7-12-30(28)31)57-41(64)32(14-9-19-52-46(48)49)56-44(67)36(21-27-10-5-4-6-11-27)59-45(68)37(60-42(33)65)23-29-25-50-26-54-29/h4-8,10-13,24-26,32-37,53H,2-3,9,14-23H2,1H3,(H2,47,63)(H,50,54)(H,51,61)(H,55,62)(H,56,67)(H,57,64)(H,58,66)(H,59,68)(H,60,65)(H4,48,49,52)/t32-,33-,34-,35-,36+,37-/m0/s1
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365n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135621
PNG
(US8846601, 6 | US9458201, 6)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O
Show InChI InChI=1S/C50H70N16O9/c1-29(67)60-36(18-11-21-57-50(53)54)44(70)66-41-25-42(68)56-20-10-8-16-35(43(52)69)61-47(73)39(23-31-26-58-34-15-6-5-14-33(31)34)64-45(71)37(17-7-9-19-51)62-46(72)38(22-30-12-3-2-4-13-30)63-48(74)40(65-49(41)75)24-32-27-55-28-59-32/h2-6,12-15,26-28,35-41,58H,7-11,16-25,51H2,1H3,(H2,52,69)(H,55,59)(H,56,68)(H,60,67)(H,61,73)(H,62,72)(H,63,74)(H,64,71)(H,65,75)(H,66,70)(H4,53,54,57)/t35-,36-,37-,38+,39-,40-,41-/m0/s1
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533n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135763
PNG
(US8846601, 148 | US9458201, 148)
Show SMILES CC(=O)NCCC[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O
Show InChI InChI=1S/C51H75N17O10/c1-29(69)57-22-10-19-37-45(74)66-39(25-31-13-4-3-5-14-31)47(76)64-38(20-12-24-60-51(55)56)46(75)67-40(26-32-28-61-34-16-7-6-15-33(32)34)48(77)63-35(43(52)72)17-8-9-21-58-42(71)27-41(49(78)65-37)68-44(73)36(62-30(2)70)18-11-23-59-50(53)54/h3-7,13-16,28,35-41,61H,8-12,17-27H2,1-2H3,(H2,52,72)(H,57,69)(H,58,71)(H,62,70)(H,63,77)(H,64,76)(H,65,78)(H,66,74)(H,67,75)(H,68,73)(H4,53,54,59)(H4,55,56,60)/t35-,36-,37-,38-,39+,40-,41-/m0/s1
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573n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM135769
PNG
(US8846601, 154 | US8846601, 202 | US9458201, 154)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C48H69N17O10/c1-26(66)59-32(14-8-20-56-47(51)52)41(70)61-33-15-7-19-55-39(68)18-17-31(40(50)69)60-45(74)36(23-28-25-58-30-13-6-5-12-29(28)30)64-42(71)34(16-9-21-57-48(53)54)62-44(73)35(22-27-10-3-2-4-11-27)63-46(75)37(24-38(49)67)65-43(33)72/h2-6,10-13,25,31-37,58H,7-9,14-24H2,1H3,(H2,49,67)(H2,50,69)(H,55,68)(H,59,66)(H,60,74)(H,61,70)(H,62,73)(H,63,75)(H,64,71)(H,65,72)(H4,51,52,56)(H4,53,54,57)/t31-,32-,33-,34-,35+,36-,37-/m0/s1
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688n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM135771
PNG
(US8846601, 156 | US9458201, 156)
Show SMILES CC(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C48H69N17O10/c1-26(66)59-32(14-8-20-56-47(51)52)41(70)61-33-15-7-19-55-39(68)18-17-31(40(50)69)60-45(74)36(23-28-25-58-30-13-6-5-12-29(28)30)64-42(71)34(16-9-21-57-48(53)54)62-44(73)35(22-27-10-3-2-4-11-27)63-46(75)37(24-38(49)67)65-43(33)72/h2-6,10-13,25,31-37,58H,7-9,14-24H2,1H3,(H2,49,67)(H2,50,69)(H,55,68)(H,59,66)(H,60,74)(H,61,70)(H,62,73)(H,63,75)(H,64,71)(H,65,72)(H4,51,52,56)(H4,53,54,57)/t31-,32+,33-,34-,35+,36-,37-/m0/s1
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840n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135617
PNG
(US8846601, 116 | US8846601, 2 | US9458201, 116)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCCN)NC1=O)C(N)=O
Show InChI InChI=1S/C50H75N17O9/c1-29(68)61-35(19-11-23-58-49(53)54)43(71)67-40-27-41(69)57-22-10-8-17-34(42(52)70)62-47(75)39(26-31-28-60-33-16-6-5-15-32(31)33)66-45(73)37(20-12-24-59-50(55)56)64-46(74)38(25-30-13-3-2-4-14-30)65-44(72)36(63-48(40)76)18-7-9-21-51/h2-6,13-16,28,34-40,60H,7-12,17-27,51H2,1H3,(H2,52,70)(H,57,69)(H,61,68)(H,62,75)(H,63,76)(H,64,74)(H,65,72)(H,66,73)(H,67,71)(H4,53,54,58)(H4,55,56,59)/t34-,35-,36-,37-,38+,39-,40-/m0/s1
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873n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135618
PNG
(US8846601, 117 | US8846601, 3 | US9458201, 117)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CO)NC1=O)C(N)=O
Show InChI InChI=1S/C47H68N16O10/c1-26(65)57-32(16-9-19-54-46(49)50)40(68)62-36-23-38(66)53-18-8-7-15-31(39(48)67)58-43(71)35(22-28-24-56-30-14-6-5-13-29(28)30)61-41(69)33(17-10-20-55-47(51)52)59-42(70)34(21-27-11-3-2-4-12-27)60-45(73)37(25-64)63-44(36)72/h2-6,11-14,24,31-37,56,64H,7-10,15-23,25H2,1H3,(H2,48,67)(H,53,66)(H,57,65)(H,58,71)(H,59,70)(H,60,73)(H,61,69)(H,62,68)(H,63,72)(H4,49,50,54)(H4,51,52,55)/t31-,32-,33-,34+,35-,36-,37-/m0/s1
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1.45E+3n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135620
PNG
(US8846601, 5 | US9458201, 5)
Show SMILES C[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O
Show InChI InChI=1S/C47H67N15O10/c1-26-40(66)60-35(22-28-12-4-3-5-13-28)44(70)59-34(18-11-21-54-47(51)72)42(68)61-36(23-29-25-55-31-15-7-6-14-30(29)31)45(71)58-32(39(48)65)16-8-9-19-52-38(64)24-37(43(69)56-26)62-41(67)33(57-27(2)63)17-10-20-53-46(49)50/h3-7,12-15,25-26,32-37,55H,8-11,16-24H2,1-2H3,(H2,48,65)(H,52,64)(H,56,69)(H,57,63)(H,58,71)(H,59,70)(H,60,66)(H,61,68)(H,62,67)(H4,49,50,53)(H3,51,54,72)/t26-,32-,33-,34-,35+,36-,37-/m0/s1
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2.05E+3n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135622
PNG
(US8846601, 7 | US9458201, 7)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCCN)NC1=O)C(N)=O
Show InChI InChI=1S/C50H75N15O9/c1-30(66)59-36(21-13-25-57-50(54)55)44(69)65-41-28-42(67)56-24-12-9-18-35(43(53)68)60-48(73)40(27-32-29-58-34-17-6-5-16-33(32)34)64-46(71)38(20-8-11-23-52)61-47(72)39(26-31-14-3-2-4-15-31)63-45(70)37(62-49(41)74)19-7-10-22-51/h2-6,14-17,29,35-41,58H,7-13,18-28,51-52H2,1H3,(H2,53,68)(H,56,67)(H,59,66)(H,60,73)(H,61,72)(H,62,74)(H,63,70)(H,64,71)(H,65,69)(H4,54,55,57)/t35-,36-,37-,38-,39+,40-,41-/m0/s1
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2.96E+3n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135623
PNG
(US8846601, 8 | US9458201, 8)
Show SMILES C[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O
Show InChI InChI=1S/C47H68N14O9/c1-27-41(65)59-36(23-29-13-4-3-5-14-29)45(69)58-35(18-8-10-20-48)43(67)60-37(24-30-26-54-32-16-7-6-15-31(30)32)46(70)57-33(40(49)64)17-9-11-21-52-39(63)25-38(44(68)55-27)61-42(66)34(56-28(2)62)19-12-22-53-47(50)51/h3-7,13-16,26-27,33-38,54H,8-12,17-25,48H2,1-2H3,(H2,49,64)(H,52,63)(H,55,68)(H,56,62)(H,57,70)(H,58,69)(H,59,65)(H,60,67)(H,61,66)(H4,50,51,53)/t27-,33-,34-,35-,36+,37-,38-/m0/s1
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3.02E+3n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


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More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM135686
PNG
(US8846601, 71 | US9458201, 71)
Show SMILES CC(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C49H71N17O10/c1-27(67)60-33(16-9-21-57-48(52)53)42(71)66-38-25-40(69)56-20-8-7-15-32(41(51)70)61-46(75)37(24-29-26-59-31-14-6-5-13-30(29)31)65-43(72)34(17-10-22-58-49(54)55)62-45(74)36(23-28-11-3-2-4-12-28)64-44(73)35(63-47(38)76)18-19-39(50)68/h2-6,11-14,26,32-38,59H,7-10,15-25H2,1H3,(H2,50,68)(H2,51,70)(H,56,69)(H,60,67)(H,61,75)(H,62,74)(H,63,76)(H,64,73)(H,65,72)(H,66,71)(H4,52,53,57)(H4,54,55,58)/t32-,33+,34-,35-,36+,37-,38-/m0/s1
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3.35E+3n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


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More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135619
PNG
(US8846601, 4 | US9458201, 4)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CO)NC1=O)C(N)=O
Show InChI InChI=1S/C47H68N14O10/c1-27(63)55-33(18-11-21-53-47(50)51)41(66)60-37-24-39(64)52-20-10-8-16-32(40(49)65)56-44(69)36(23-29-25-54-31-15-6-5-14-30(29)31)59-42(67)34(17-7-9-19-48)57-43(68)35(22-28-12-3-2-4-13-28)58-46(71)38(26-62)61-45(37)70/h2-6,12-15,25,32-38,54,62H,7-11,16-24,26,48H2,1H3,(H2,49,65)(H,52,64)(H,55,63)(H,56,69)(H,57,68)(H,58,71)(H,59,67)(H,60,66)(H,61,70)(H4,50,51,53)/t32-,33-,34-,35+,36-,37-,38-/m0/s1
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4.29E+3n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


Citation and Details
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM135769
PNG
(US8846601, 154 | US8846601, 202 | US9458201, 154)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C48H69N17O10/c1-26(66)59-32(14-8-20-56-47(51)52)41(70)61-33-15-7-19-55-39(68)18-17-31(40(50)69)60-45(74)36(23-28-25-58-30-13-6-5-12-29(28)30)64-42(71)34(16-9-21-57-48(53)54)62-44(73)35(22-27-10-3-2-4-11-27)63-46(75)37(24-38(49)67)65-43(33)72/h2-6,10-13,25,31-37,58H,7-9,14-24H2,1H3,(H2,49,67)(H2,50,69)(H,55,68)(H,59,66)(H,60,74)(H,61,70)(H,62,73)(H,63,75)(H,64,71)(H,65,72)(H4,51,52,56)(H4,53,54,57)/t31-,32-,33-,34-,35+,36-,37-/m0/s1
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n/an/an/an/a 25n/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


Citation and Details
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM135775
PNG
(US8846601, 160 | US9458201, 160)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCC(=O)NCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C48H69N17O10/c1-26(66)59-32(15-8-19-56-47(51)52)41(70)61-33-14-7-17-39(68)55-21-18-31(40(50)69)60-45(74)36(23-28-25-58-30-13-6-5-12-29(28)30)64-43(72)34(16-9-20-57-48(53)54)62-44(73)35(22-27-10-3-2-4-11-27)63-46(75)37(24-38(49)67)65-42(33)71/h2-6,10-13,25,31-37,58H,7-9,14-24H2,1H3,(H2,49,67)(H2,50,69)(H,55,68)(H,59,66)(H,60,74)(H,61,70)(H,62,73)(H,63,75)(H,64,72)(H,65,71)(H4,51,52,56)(H4,53,54,57)/t31-,32-,33-,34-,35+,36-,37-/m0/s1
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n/an/an/an/a 18n/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


Citation and Details
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM135776
PNG
(US8846601, 161 | US9458201, 161)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C48H69N17O10/c1-26(66)59-32(15-8-20-56-47(51)52)41(70)62-34-17-18-39(68)55-19-7-14-31(40(50)69)60-45(74)36(23-28-25-58-30-13-6-5-12-29(28)30)64-42(71)33(16-9-21-57-48(53)54)61-44(73)35(22-27-10-3-2-4-11-27)63-46(75)37(24-38(49)67)65-43(34)72/h2-6,10-13,25,31-37,58H,7-9,14-24H2,1H3,(H2,49,67)(H2,50,69)(H,55,68)(H,59,66)(H,60,74)(H,61,73)(H,62,70)(H,63,75)(H,64,71)(H,65,72)(H4,51,52,56)(H4,53,54,57)/t31-,32-,33-,34-,35+,36-,37-/m0/s1
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n/an/an/an/a 13n/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135686
PNG
(US8846601, 71 | US9458201, 71)
Show SMILES CC(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C49H71N17O10/c1-27(67)60-33(16-9-21-57-48(52)53)42(71)66-38-25-40(69)56-20-8-7-15-32(41(51)70)61-46(75)37(24-29-26-59-31-14-6-5-13-30(29)31)65-43(72)34(17-10-22-58-49(54)55)62-45(74)36(23-28-11-3-2-4-12-28)64-44(73)35(63-47(38)76)18-19-39(50)68/h2-6,11-14,26,32-38,59H,7-10,15-25H2,1H3,(H2,50,68)(H2,51,70)(H,56,69)(H,60,67)(H,61,75)(H,62,74)(H,63,76)(H,64,73)(H,65,72)(H,66,71)(H4,52,53,57)(H4,54,55,58)/t32-,33+,34-,35-,36+,37-,38-/m0/s1
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n/an/an/an/a 2n/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135765
PNG
(US8846601, 150 | US9458201, 150)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C49H71N17O10/c1-27(67)60-33(14-8-22-57-48(52)53)42(71)62-34-15-7-21-56-40(69)20-18-32(41(51)70)61-47(76)38(25-29-26-59-31-13-6-5-12-30(29)31)66-44(73)35(16-9-23-58-49(54)55)63-46(75)37(24-28-10-3-2-4-11-28)65-45(74)36(64-43(34)72)17-19-39(50)68/h2-6,10-13,26,32-38,59H,7-9,14-25H2,1H3,(H2,50,68)(H2,51,70)(H,56,69)(H,60,67)(H,61,76)(H,62,71)(H,63,75)(H,64,72)(H,65,74)(H,66,73)(H4,52,53,57)(H4,54,55,58)/t32-,33-,34-,35-,36-,37+,38-/m0/s1
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n/an/an/an/a 0.300n/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


Citation and Details
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM135774
PNG
(US8846601, 159 | US9458201, 159)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCNC(=O)CCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C49H71N17O10/c1-27(67)60-33(15-8-21-57-48(52)53)42(71)64-36-20-23-56-40(69)17-7-14-32(41(51)70)61-47(76)38(25-29-26-59-31-13-6-5-12-30(29)31)66-43(72)34(16-9-22-58-49(54)55)62-46(75)37(24-28-10-3-2-4-11-28)65-44(73)35(63-45(36)74)18-19-39(50)68/h2-6,10-13,26,32-38,59H,7-9,14-25H2,1H3,(H2,50,68)(H2,51,70)(H,56,69)(H,60,67)(H,61,76)(H,62,75)(H,63,74)(H,64,71)(H,65,73)(H,66,72)(H4,52,53,57)(H4,54,55,58)/t32-,33-,34-,35-,36-,37+,38-/m0/s1
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n/an/an/an/a 26n/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135769
PNG
(US8846601, 154 | US8846601, 202 | US9458201, 154)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C48H69N17O10/c1-26(66)59-32(14-8-20-56-47(51)52)41(70)61-33-15-7-19-55-39(68)18-17-31(40(50)69)60-45(74)36(23-28-25-58-30-13-6-5-12-29(28)30)64-42(71)34(16-9-21-57-48(53)54)62-44(73)35(22-27-10-3-2-4-11-27)63-46(75)37(24-38(49)67)65-43(33)72/h2-6,10-13,25,31-37,58H,7-9,14-24H2,1H3,(H2,49,67)(H2,50,69)(H,55,68)(H,59,66)(H,60,74)(H,61,70)(H,62,73)(H,63,75)(H,64,71)(H,65,72)(H4,51,52,56)(H4,53,54,57)/t31-,32-,33-,34-,35+,36-,37-/m0/s1
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n/an/an/an/a 0.625n/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135771
PNG
(US8846601, 156 | US9458201, 156)
Show SMILES CC(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C48H69N17O10/c1-26(66)59-32(14-8-20-56-47(51)52)41(70)61-33-15-7-19-55-39(68)18-17-31(40(50)69)60-45(74)36(23-28-25-58-30-13-6-5-12-29(28)30)64-42(71)34(16-9-21-57-48(53)54)62-44(73)35(22-27-10-3-2-4-11-27)63-46(75)37(24-38(49)67)65-43(33)72/h2-6,10-13,25,31-37,58H,7-9,14-24H2,1H3,(H2,49,67)(H2,50,69)(H,55,68)(H,59,66)(H,60,74)(H,61,70)(H,62,73)(H,63,75)(H,64,71)(H,65,72)(H4,51,52,56)(H4,53,54,57)/t31-,32+,33-,34-,35+,36-,37-/m0/s1
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n/an/an/an/a 2n/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135777
PNG
(US8846601, 162 | US9458201, 162)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C50H70N16O10/c1-28(67)60-33(16-9-21-58-49(53)54)43(71)61-34-15-7-8-20-57-41(69)27-36(42(52)70)63-47(75)38(25-30-18-19-31-13-5-6-14-32(31)23-30)64-45(73)35(17-10-22-59-50(55)56)62-46(74)37(24-29-11-3-2-4-12-29)65-48(76)39(26-40(51)68)66-44(34)72/h2-6,11-14,18-19,23,33-39H,7-10,15-17,20-22,24-27H2,1H3,(H2,51,68)(H2,52,70)(H,57,69)(H,60,67)(H,61,71)(H,62,74)(H,63,75)(H,64,73)(H,65,76)(H,66,72)(H4,53,54,58)(H4,55,56,59)/t33-,34-,35-,36-,37+,38-,39-/m0/s1
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n/an/an/an/a 0.850n/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


Citation and Details
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM135686
PNG
(US8846601, 71 | US9458201, 71)
Show SMILES CC(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C49H71N17O10/c1-27(67)60-33(16-9-21-57-48(52)53)42(71)66-38-25-40(69)56-20-8-7-15-32(41(51)70)61-46(75)37(24-29-26-59-31-14-6-5-13-30(29)31)65-43(72)34(17-10-22-58-49(54)55)62-45(74)36(23-28-11-3-2-4-12-28)64-44(73)35(63-47(38)76)18-19-39(50)68/h2-6,11-14,26,32-38,59H,7-10,15-25H2,1H3,(H2,50,68)(H2,51,70)(H,56,69)(H,60,67)(H,61,75)(H,62,74)(H,63,76)(H,64,73)(H,65,72)(H,66,71)(H4,52,53,57)(H4,54,55,58)/t32-,33+,34-,35-,36+,37-,38-/m0/s1
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n/an/an/an/a 60n/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135776
PNG
(US8846601, 161 | US9458201, 161)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C48H69N17O10/c1-26(66)59-32(15-8-20-56-47(51)52)41(70)62-34-17-18-39(68)55-19-7-14-31(40(50)69)60-45(74)36(23-28-25-58-30-13-6-5-12-29(28)30)64-42(71)33(16-9-21-57-48(53)54)61-44(73)35(22-27-10-3-2-4-11-27)63-46(75)37(24-38(49)67)65-43(34)72/h2-6,10-13,25,31-37,58H,7-9,14-24H2,1H3,(H2,49,67)(H2,50,69)(H,55,68)(H,59,66)(H,60,74)(H,61,73)(H,62,70)(H,63,75)(H,64,71)(H,65,72)(H4,51,52,56)(H4,53,54,57)/t31-,32-,33-,34-,35+,36-,37-/m0/s1
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n/an/an/an/a 0.413n/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


Citation and Details
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM135770
PNG
(US8846601, 155 | US9458201, 155)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C48H69N17O10/c1-26(66)59-31(16-9-19-56-47(51)52)41(70)60-32-15-7-8-18-55-39(68)24-34(40(50)69)62-45(74)36(22-28-25-58-30-14-6-5-13-29(28)30)64-43(72)33(17-10-20-57-48(53)54)61-44(73)35(21-27-11-3-2-4-12-27)63-46(75)37(23-38(49)67)65-42(32)71/h2-6,11-14,25,31-37,58H,7-10,15-24H2,1H3,(H2,49,67)(H2,50,69)(H,55,68)(H,59,66)(H,60,70)(H,61,73)(H,62,74)(H,63,75)(H,64,72)(H,65,71)(H4,51,52,56)(H4,53,54,57)/t31-,32-,33-,34-,35+,36-,37-/m0/s1
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n/an/an/an/a 14n/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


Citation and Details
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM135767
PNG
(US8846601, 152 | US9458201, 152)
Show SMILES CC(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C49H71N17O10/c1-27(67)60-33(14-8-22-57-48(52)53)42(71)62-34-15-7-21-56-40(69)20-18-32(41(51)70)61-47(76)38(25-29-26-59-31-13-6-5-12-30(29)31)66-44(73)35(16-9-23-58-49(54)55)63-46(75)37(24-28-10-3-2-4-11-28)65-45(74)36(64-43(34)72)17-19-39(50)68/h2-6,10-13,26,32-38,59H,7-9,14-25H2,1H3,(H2,50,68)(H2,51,70)(H,56,69)(H,60,67)(H,61,76)(H,62,71)(H,63,75)(H,64,72)(H,65,74)(H,66,73)(H4,52,53,57)(H4,54,55,58)/t32-,33+,34-,35-,36-,37+,38-/m0/s1
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n/an/an/an/a 18n/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135770
PNG
(US8846601, 155 | US9458201, 155)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C48H69N17O10/c1-26(66)59-31(16-9-19-56-47(51)52)41(70)60-32-15-7-8-18-55-39(68)24-34(40(50)69)62-45(74)36(22-28-25-58-30-14-6-5-13-29(28)30)64-43(72)33(17-10-20-57-48(53)54)61-44(73)35(21-27-11-3-2-4-12-27)63-46(75)37(23-38(49)67)65-42(32)71/h2-6,11-14,25,31-37,58H,7-10,15-24H2,1H3,(H2,49,67)(H2,50,69)(H,55,68)(H,59,66)(H,60,70)(H,61,73)(H,62,74)(H,63,75)(H,64,72)(H,65,71)(H4,51,52,56)(H4,53,54,57)/t31-,32-,33-,34-,35+,36-,37-/m0/s1
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n/an/an/an/a 0.189n/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135774
PNG
(US8846601, 159 | US9458201, 159)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCNC(=O)CCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C49H71N17O10/c1-27(67)60-33(15-8-21-57-48(52)53)42(71)64-36-20-23-56-40(69)17-7-14-32(41(51)70)61-47(76)38(25-29-26-59-31-13-6-5-12-30(29)31)66-43(72)34(16-9-22-58-49(54)55)62-46(75)37(24-28-10-3-2-4-11-28)65-44(73)35(63-45(36)74)18-19-39(50)68/h2-6,10-13,26,32-38,59H,7-9,14-25H2,1H3,(H2,50,68)(H2,51,70)(H,56,69)(H,60,67)(H,61,76)(H,62,75)(H,63,74)(H,64,71)(H,65,73)(H,66,72)(H4,52,53,57)(H4,54,55,58)/t32-,33-,34-,35-,36-,37+,38-/m0/s1
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n/an/an/an/a 0.825n/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135775
PNG
(US8846601, 160 | US9458201, 160)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCC(=O)NCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C48H69N17O10/c1-26(66)59-32(15-8-19-56-47(51)52)41(70)61-33-14-7-17-39(68)55-21-18-31(40(50)69)60-45(74)36(23-28-25-58-30-13-6-5-12-29(28)30)64-43(72)34(16-9-20-57-48(53)54)62-44(73)35(22-27-10-3-2-4-11-27)63-46(75)37(24-38(49)67)65-42(33)71/h2-6,10-13,25,31-37,58H,7-9,14-24H2,1H3,(H2,49,67)(H2,50,69)(H,55,68)(H,59,66)(H,60,74)(H,61,70)(H,62,73)(H,63,75)(H,64,72)(H,65,71)(H4,51,52,56)(H4,53,54,57)/t31-,32-,33-,34-,35+,36-,37-/m0/s1
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n/an/an/an/a 0.245n/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


Citation and Details
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135767
PNG
(US8846601, 152 | US9458201, 152)
Show SMILES CC(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C49H71N17O10/c1-27(67)60-33(14-8-22-57-48(52)53)42(71)62-34-15-7-21-56-40(69)20-18-32(41(51)70)61-47(76)38(25-29-26-59-31-13-6-5-12-30(29)31)66-44(73)35(16-9-23-58-49(54)55)63-46(75)37(24-28-10-3-2-4-11-28)65-45(74)36(64-43(34)72)17-19-39(50)68/h2-6,10-13,26,32-38,59H,7-9,14-25H2,1H3,(H2,50,68)(H2,51,70)(H,56,69)(H,60,67)(H,61,76)(H,62,71)(H,63,75)(H,64,72)(H,65,74)(H,66,73)(H4,52,53,57)(H4,54,55,58)/t32-,33+,34-,35-,36-,37+,38-/m0/s1
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n/an/an/an/a 0.5n/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


Citation and Details
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM135765
PNG
(US8846601, 150 | US9458201, 150)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C49H71N17O10/c1-27(67)60-33(14-8-22-57-48(52)53)42(71)62-34-15-7-21-56-40(69)20-18-32(41(51)70)61-47(76)38(25-29-26-59-31-13-6-5-12-30(29)31)66-44(73)35(16-9-23-58-49(54)55)63-46(75)37(24-28-10-3-2-4-11-28)65-45(74)36(64-43(34)72)17-19-39(50)68/h2-6,10-13,26,32-38,59H,7-9,14-25H2,1H3,(H2,50,68)(H2,51,70)(H,56,69)(H,60,67)(H,61,76)(H,62,71)(H,63,75)(H,64,72)(H,65,74)(H,66,73)(H4,52,53,57)(H4,54,55,58)/t32-,33-,34-,35-,36-,37+,38-/m0/s1
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n/an/an/an/a 9n/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


Citation and Details
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM135771
PNG
(US8846601, 156 | US9458201, 156)
Show SMILES CC(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C48H69N17O10/c1-26(66)59-32(14-8-20-56-47(51)52)41(70)61-33-15-7-19-55-39(68)18-17-31(40(50)69)60-45(74)36(23-28-25-58-30-13-6-5-12-29(28)30)64-42(71)34(16-9-21-57-48(53)54)62-44(73)35(22-27-10-3-2-4-11-27)63-46(75)37(24-38(49)67)65-43(33)72/h2-6,10-13,25,31-37,58H,7-9,14-24H2,1H3,(H2,49,67)(H2,50,69)(H,55,68)(H,59,66)(H,60,74)(H,61,70)(H,62,73)(H,63,75)(H,64,71)(H,65,72)(H4,51,52,56)(H4,53,54,57)/t31-,32+,33-,34-,35+,36-,37-/m0/s1
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n/an/an/an/a 80n/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


Citation and Details
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM135777
PNG
(US8846601, 162 | US9458201, 162)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C50H70N16O10/c1-28(67)60-33(16-9-21-58-49(53)54)43(71)61-34-15-7-8-20-57-41(69)27-36(42(52)70)63-47(75)38(25-30-18-19-31-13-5-6-14-32(31)23-30)64-45(73)35(17-10-22-59-50(55)56)62-46(74)37(24-29-11-3-2-4-12-29)65-48(76)39(26-40(51)68)66-44(34)72/h2-6,11-14,18-19,23,33-39H,7-10,15-17,20-22,24-27H2,1H3,(H2,51,68)(H2,52,70)(H,57,69)(H,60,67)(H,61,71)(H,62,74)(H,63,75)(H,64,73)(H,65,76)(H,66,72)(H4,53,54,58)(H4,55,56,59)/t33-,34-,35-,36-,37+,38-,39-/m0/s1
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n/an/an/an/a 22n/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%