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Patent code US9464044

Compile Data Set for Download or QSAR
Found 101 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250432
PNG
(US9464044, 22)
Show SMILES CN(CC1(CC1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O)S(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C23H30FN3O4S/c1-27(32(30,31)18-5-3-2-4-17(18)24)13-22(6-7-22)21(29)26-19-15-8-14-9-16(19)12-23(10-14,11-15)20(25)28/h2-5,14-16,19H,6-13H2,1H3,(H2,25,28)(H,26,29)/t14?,15?,16?,19-,23?
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n/an/a 0.0200n/an/an/an/an/an/a



AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250460
PNG
(US9464044, 62)
Show SMILES CN(C1(CC1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O)S(=O)(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C22H28ClN3O4S/c1-26(31(29,30)17-4-2-3-16(23)9-17)22(5-6-22)20(28)25-18-14-7-13-8-15(18)12-21(10-13,11-14)19(24)27/h2-4,9,13-15,18H,5-8,10-12H2,1H3,(H2,24,27)(H,25,28)/t13?,14?,15?,18-,21?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250418
PNG
(US9464044, 8)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CNS(=O)(=O)c4cccc(Cl)c4F)CC1)C(C3)C2
Show InChI InChI=1S/C22H27ClFN3O4S/c23-15-2-1-3-16(17(15)24)32(30,31)26-11-21(4-5-21)20(29)27-18-13-6-12-7-14(18)10-22(8-12,9-13)19(25)28/h1-3,12-14,18,26H,4-11H2,(H2,25,28)(H,27,29)/t12?,13?,14?,18-,22?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM50112152
PNG
(CHEMBL3608401 | US9464044, 84)
Show SMILES CC(C)(NS(=O)(=O)c1c(F)cccc1F)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O
Show InChI InChI=1S/C21H27F2N3O4S/c1-20(2,26-31(29,30)17-14(22)4-3-5-15(17)23)19(28)25-16-12-6-11-7-13(16)10-21(8-11,9-12)18(24)27/h3-5,11-13,16,26H,6-10H2,1-2H3,(H2,24,27)(H,25,28)/t11?,12?,13?,16-,21?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250453
PNG
(US9464044, 50)
Show SMILES Cn1ccc2cccc(c12)S(=O)(=O)NC1(CC1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O
Show InChI InChI=1S/C24H30N4O4S/c1-28-8-5-15-3-2-4-18(20(15)28)33(31,32)27-24(6-7-24)22(30)26-19-16-9-14-10-17(19)13-23(11-14,12-16)21(25)29/h2-5,8,14,16-17,19,27H,6-7,9-13H2,1H3,(H2,25,29)(H,26,30)/t14?,16?,17?,19-,23?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM50112133
PNG
(CHEMBL3609861 | US9464044, 71)
Show SMILES CC(C)(NS(=O)(=O)c1ccccc1F)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O
Show InChI InChI=1S/C21H28FN3O4S/c1-20(2,25-30(28,29)16-6-4-3-5-15(16)22)19(27)24-17-13-7-12-8-14(17)11-21(9-12,10-13)18(23)26/h3-6,12-14,17,25H,7-11H2,1-2H3,(H2,23,26)(H,24,27)/t12?,13?,14?,17-,21?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM50112143
PNG
(CHEMBL3609871 | US9464044, 73)
Show SMILES CC(C)(NS(=O)(=O)c1cccc(Cl)c1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O
Show InChI InChI=1S/C21H28ClN3O4S/c1-20(2,25-30(28,29)16-5-3-4-15(22)8-16)19(27)24-17-13-6-12-7-14(17)11-21(9-12,10-13)18(23)26/h3-5,8,12-14,17,25H,6-7,9-11H2,1-2H3,(H2,23,26)(H,24,27)/t12?,13?,14?,17-,21?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250486
PNG
(US9464044, 119)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cccc(NS(=O)(=O)c4cc(Cl)cc(Cl)c4)c1)C(C3)C2
Show InChI InChI=1S/C24H25Cl2N3O4S/c25-17-7-18(26)9-20(8-17)34(32,33)29-19-3-1-2-14(6-19)22(30)28-21-15-4-13-5-16(21)12-24(10-13,11-15)23(27)31/h1-3,6-9,13,15-16,21,29H,4-5,10-12H2,(H2,27,31)(H,28,30)/t13?,15?,16?,21-,24?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250474
PNG
(US9464044, 102)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cccc(NS(=O)(=O)c4cccs4)c1)C(C3)C2
Show InChI InChI=1S/C22H25N3O4S2/c23-21(27)22-10-13-7-15(11-22)19(16(8-13)12-22)24-20(26)14-3-1-4-17(9-14)25-31(28,29)18-5-2-6-30-18/h1-6,9,13,15-16,19,25H,7-8,10-12H2,(H2,23,27)(H,24,26)/t13?,15?,16?,19-,22?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250466
PNG
(US9464044, 72)
Show SMILES CN(C(C)(C)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O)S(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C22H30FN3O4S/c1-21(2,26(3)31(29,30)17-7-5-4-6-16(17)23)20(28)25-18-14-8-13-9-15(18)12-22(10-13,11-14)19(24)27/h4-7,13-15,18H,8-12H2,1-3H3,(H2,24,27)(H,25,28)/t13?,14?,15?,18-,22?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250437
PNG
(US9464044, 31)
Show SMILES CN(CC1(CC1)C(=O)NC12CC3CC(CC(C3)C1)C2)S(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C22H29FN2O3S/c1-25(29(27,28)19-5-3-2-4-18(19)23)14-21(6-7-21)20(26)24-22-11-15-8-16(12-22)10-17(9-15)13-22/h2-5,15-17H,6-14H2,1H3,(H,24,26)
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250436
PNG
(US9464044, 28)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CNS(=O)(=O)c4ccccc4)CC1)C(C3)C2
Show InChI InChI=1S/C22H29N3O4S/c23-19(26)22-10-14-8-15(11-22)18(16(9-14)12-22)25-20(27)21(6-7-21)13-24-30(28,29)17-4-2-1-3-5-17/h1-5,14-16,18,24H,6-13H2,(H2,23,26)(H,25,27)/t14?,15?,16?,18-,22?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250435
PNG
(US9464044, 26)
Show SMILES Cn1ccc2cc(ccc12)S(=O)(=O)NCC1(CC1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O
Show InChI InChI=1S/C25H32N4O4S/c1-29-7-4-16-10-19(2-3-20(16)29)34(32,33)27-14-24(5-6-24)23(31)28-21-17-8-15-9-18(21)13-25(11-15,12-17)22(26)30/h2-4,7,10,15,17-18,21,27H,5-6,8-9,11-14H2,1H3,(H2,26,30)(H,28,31)/t15?,17?,18?,21-,25?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250438
PNG
(US9464044, 32)
Show SMILES CCN(CC1(CC1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O)S(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C24H32FN3O4S/c1-2-28(33(31,32)19-6-4-3-5-18(19)25)14-23(7-8-23)22(30)27-20-16-9-15-10-17(20)13-24(11-15,12-16)21(26)29/h3-6,15-17,20H,2,7-14H2,1H3,(H2,26,29)(H,27,30)/t15?,16?,17?,20-,24?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250439
PNG
(US9464044, 33)
Show SMILES OCCC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CNS(=O)(=O)c4ccccc4F)CC1)C(C3)C2
Show InChI InChI=1S/C24H31FN2O5S/c25-18-3-1-2-4-19(18)33(31,32)26-14-23(6-7-23)22(30)27-21-16-9-15-10-17(21)13-24(11-15,12-16)20(29)5-8-28/h1-4,15-17,21,26,28H,5-14H2,(H,27,30)/t15?,16?,17?,21-,24?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250444
PNG
(US9464044, 40)
Show SMILES Cc1cccc(F)c1S(=O)(=O)NC1(CC1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O
Show InChI InChI=1S/C22H28FN3O4S/c1-12-3-2-4-16(23)18(12)31(29,30)26-22(5-6-22)20(28)25-17-14-7-13-8-15(17)11-21(9-13,10-14)19(24)27/h2-4,13-15,17,26H,5-11H2,1H3,(H2,24,27)(H,25,28)/t13?,14?,15?,17-,21?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250472
PNG
(US9464044, 99)
Show SMILES CN(c1cccc(c1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O)S(=O)(=O)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C26H28F3N3O4S/c1-32(37(35,36)21-8-3-2-7-20(21)26(27,28)29)19-6-4-5-16(11-19)23(33)31-22-17-9-15-10-18(22)14-25(12-15,13-17)24(30)34/h2-8,11,15,17-18,22H,9-10,12-14H2,1H3,(H2,30,34)(H,31,33)/t15?,17?,18?,22-,25?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM50112142
PNG
(CHEMBL3609870 | US9464044, 81)
Show SMILES CC(C)(NS(=O)(=O)c1ccccc1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O
Show InChI InChI=1S/C21H29N3O4S/c1-20(2,24-29(27,28)16-6-4-3-5-7-16)19(26)23-17-14-8-13-9-15(17)12-21(10-13,11-14)18(22)25/h3-7,13-15,17,24H,8-12H2,1-2H3,(H2,22,25)(H,23,26)/t13?,14?,15?,17-,21?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM50112127
PNG
(CHEMBL3608407 | US9464044, 76)
Show SMILES CC(C)(NS(=O)(=O)c1ccccc1F)C(=O)N[C@H]1C2CC3CC1CC(CO)(C3)C2
Show InChI InChI=1S/C21H29FN2O4S/c1-20(2,24-29(27,28)17-6-4-3-5-16(17)22)19(26)23-18-14-7-13-8-15(18)11-21(9-13,10-14)12-25/h3-6,13-15,18,24-25H,7-12H2,1-2H3,(H,23,26)/t13?,14?,15?,18-,21?
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n/an/a 2.40n/an/an/an/an/an/a



AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250420
PNG
(US9464044, 10)
Show SMILES Cc1cccc(F)c1S(=O)(=O)NCC1(CC1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O
Show InChI InChI=1S/C23H30FN3O4S/c1-13-3-2-4-17(24)19(13)32(30,31)26-12-22(5-6-22)21(29)27-18-15-7-14-8-16(18)11-23(9-14,10-15)20(25)28/h2-4,14-16,18,26H,5-12H2,1H3,(H2,25,28)(H,27,29)/t14?,15?,16?,18-,23?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250417
PNG
(US9464044, 7)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CNS(=O)(=O)c4cccc(Cl)c4)CC1)C(C3)C2
Show InChI InChI=1S/C22H28ClN3O4S/c23-16-2-1-3-17(8-16)31(29,30)25-12-21(4-5-21)20(28)26-18-14-6-13-7-15(18)11-22(9-13,10-14)19(24)27/h1-3,8,13-15,18,25H,4-7,9-12H2,(H2,24,27)(H,26,28)/t13?,14?,15?,18-,22?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM50112126
PNG
(CHEMBL3608406 | US9464044, 74)
Show SMILES CC(C)(NS(=O)(=O)c1ccccc1F)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C#N
Show InChI InChI=1S/C21H26FN3O3S/c1-20(2,25-29(27,28)17-6-4-3-5-16(17)22)19(26)24-18-14-7-13-8-15(18)11-21(9-13,10-14)12-23/h3-6,13-15,18,25H,7-11H2,1-2H3,(H,24,26)/t13?,14?,15?,18-,21?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250480
PNG
(US9464044, 113)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cccc([N-]S(=O)(=O)c4cccc(Cl)c4F)c1)C(C3)C2
Show InChI InChI=1S/C24H24ClFN3O4S/c25-18-5-2-6-19(20(18)26)34(32,33)29-17-4-1-3-14(9-17)22(30)28-21-15-7-13-8-16(21)12-24(10-13,11-15)23(27)31/h1-6,9,13,15-16,21H,7-8,10-12H2,(H2,27,31)(H,28,30)/q-1/t13?,15?,16?,21-,24?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250416
PNG
(US9464044, 5)
Show SMILES Cc1c(Cl)cccc1S(=O)(=O)NCC1(CC1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O
Show InChI InChI=1S/C23H30ClN3O4S/c1-13-17(24)3-2-4-18(13)32(30,31)26-12-22(5-6-22)21(29)27-19-15-7-14-8-16(19)11-23(9-14,10-15)20(25)28/h2-4,14-16,19,26H,5-12H2,1H3,(H2,25,28)(H,27,29)/t14?,15?,16?,19-,23?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250423
PNG
(US9464044, 13)
Show SMILES CN(CC1(CC1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O)S(=O)(=O)c1c(C)cccc1F
Show InChI InChI=1S/C24H32FN3O4S/c1-14-4-3-5-18(25)20(14)33(31,32)28(2)13-23(6-7-23)22(30)27-19-16-8-15-9-17(19)12-24(10-15,11-16)21(26)29/h3-5,15-17,19H,6-13H2,1-2H3,(H2,26,29)(H,27,30)/t15?,16?,17?,19-,24?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250459
PNG
(US9464044, 61)
Show SMILES CN(C1(CC1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O)S(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C22H28FN3O4S/c1-26(31(29,30)17-5-3-2-4-16(17)23)22(6-7-22)20(28)25-18-14-8-13-9-15(18)12-21(10-13,11-14)19(24)27/h2-5,13-15,18H,6-12H2,1H3,(H2,24,27)(H,25,28)/t13?,14?,15?,18-,21?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250477
PNG
(US9464044, 106)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cccc(NS(=O)(=O)c4ccccc4Cl)c1)C(C3)C2
Show InChI InChI=1S/C24H26ClN3O4S/c25-19-6-1-2-7-20(19)33(31,32)28-18-5-3-4-15(10-18)22(29)27-21-16-8-14-9-17(21)13-24(11-14,12-16)23(26)30/h1-7,10,14,16-17,21,28H,8-9,11-13H2,(H2,26,30)(H,27,29)/t14?,16?,17?,21-,24?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250484
PNG
(US9464044, 117)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cccc(NS(=O)(=O)c4c(Cl)cc(Cl)cc4Cl)c1)C(C3)C2
Show InChI InChI=1S/C24H24Cl3N3O4S/c25-16-7-18(26)21(19(27)8-16)35(33,34)30-17-3-1-2-13(6-17)22(31)29-20-14-4-12-5-15(20)11-24(9-12,10-14)23(28)32/h1-3,6-8,12,14-15,20,30H,4-5,9-11H2,(H2,28,32)(H,29,31)/t12?,14?,15?,20-,24?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250426
PNG
(US9464044, 16)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CNS(=O)(=O)c4cc(Cl)c(Cl)cc4F)CC1)C(C3)C2
Show InChI InChI=1S/C22H26Cl2FN3O4S/c23-14-5-16(25)17(6-15(14)24)33(31,32)27-10-21(1-2-21)20(30)28-18-12-3-11-4-13(18)9-22(7-11,8-12)19(26)29/h5-6,11-13,18,27H,1-4,7-10H2,(H2,26,29)(H,28,30)/t11?,12?,13?,18-,22?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250465
PNG
(US9464044, 70)
Show SMILES Cc1c(Cl)cccc1S(=O)(=O)NCC(C)(C)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O
Show InChI InChI=1S/C23H32ClN3O4S/c1-13-17(24)5-4-6-18(13)32(30,31)26-12-22(2,3)21(29)27-19-15-7-14-8-16(19)11-23(9-14,10-15)20(25)28/h4-6,14-16,19,26H,7-12H2,1-3H3,(H2,25,28)(H,27,29)/t14?,15?,16?,19-,23?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM50112141
PNG
(CHEMBL3609869 | US9464044, 3)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CNS(=O)(=O)c4ccccc4F)CC1)C(C3)C2
Show InChI InChI=1S/C22H28FN3O4S/c23-16-3-1-2-4-17(16)31(29,30)25-12-21(5-6-21)20(28)26-18-14-7-13-8-15(18)11-22(9-13,10-14)19(24)27/h1-4,13-15,18,25H,5-12H2,(H2,24,27)(H,26,28)/t13?,14?,15?,18-,22?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250446
PNG
(US9464044, 42)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CC1)NS(=O)(=O)c1ccc(F)cc1)C(C3)C2
Show InChI InChI=1S/C21H26FN3O4S/c22-15-1-3-16(4-2-15)30(28,29)25-21(5-6-21)19(27)24-17-13-7-12-8-14(17)11-20(9-12,10-13)18(23)26/h1-4,12-14,17,25H,5-11H2,(H2,23,26)(H,24,27)/t12?,13?,14?,17-,20?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250443
PNG
(US9464044, 38)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CC1)NS(=O)(=O)c1cccc(Cl)c1)C(C3)C2
Show InChI InChI=1S/C21H26ClN3O4S/c22-15-2-1-3-16(8-15)30(28,29)25-21(4-5-21)19(27)24-17-13-6-12-7-14(17)11-20(9-12,10-13)18(23)26/h1-3,8,12-14,17,25H,4-7,9-11H2,(H2,23,26)(H,24,27)/t12?,13?,14?,17-,20?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250463
PNG
(US9464044, 67)
Show SMILES CC(C)(CNS(=O)(=O)c1cccc(Cl)c1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O
Show InChI InChI=1S/C22H30ClN3O4S/c1-21(2,12-25-31(29,30)17-5-3-4-16(23)8-17)20(28)26-18-14-6-13-7-15(18)11-22(9-13,10-14)19(24)27/h3-5,8,13-15,18,25H,6-7,9-12H2,1-2H3,(H2,24,27)(H,26,28)/t13?,14?,15?,18-,22?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250488
PNG
(US9464044, 121)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cccc(NS(=O)(=O)c4ccc(F)cc4F)c1)C(C3)C2
Show InChI InChI=1S/C24H25F2N3O4S/c25-17-4-5-20(19(26)9-17)34(32,33)29-18-3-1-2-14(8-18)22(30)28-21-15-6-13-7-16(21)12-24(10-13,11-15)23(27)31/h1-5,8-9,13,15-16,21,29H,6-7,10-12H2,(H2,27,31)(H,28,30)/t13?,15?,16?,21-,24?
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n/an/a 7.80n/an/an/an/an/an/a



AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250454
PNG
(US9464044, 55)
Show SMILES Clc1cccc(c1)S(=O)(=O)NC1(CC1)C(=O)NC1CC2CCC1C2
Show InChI InChI=1S/C17H21ClN2O3S/c18-13-2-1-3-14(10-13)24(22,23)20-17(6-7-17)16(21)19-15-9-11-4-5-12(15)8-11/h1-3,10-12,15,20H,4-9H2,(H,19,21)
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n/an/a 8.30n/an/an/an/an/an/a



AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM50112140
PNG
(CHEMBL3609868 | US9464044, 68)
Show SMILES CC(C)(CNS(=O)(=O)c1ccccc1F)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O
Show InChI InChI=1S/C22H30FN3O4S/c1-21(2,12-25-31(29,30)17-6-4-3-5-16(17)23)20(28)26-18-14-7-13-8-15(18)11-22(9-13,10-14)19(24)27/h3-6,13-15,18,25H,7-12H2,1-2H3,(H2,24,27)(H,26,28)/t13?,14?,15?,18-,22?
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n/an/a 8.90n/an/an/an/an/an/a



AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250455
PNG
(US9464044, 57)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CC1)NC(=O)c1ccc(F)c(F)c1)C(C3)C2
Show InChI InChI=1S/C22H25F2N3O3/c23-15-2-1-12(7-16(15)24)18(28)27-22(3-4-22)20(30)26-17-13-5-11-6-14(17)10-21(8-11,9-13)19(25)29/h1-2,7,11,13-14,17H,3-6,8-10H2,(H2,25,29)(H,26,30)(H,27,28)/t11?,13?,14?,17-,21?
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n/an/a 9.30n/an/an/an/an/an/a



AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250422
PNG
(US9464044, 12)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CNS(=O)(=O)c4c(F)cc(F)cc4F)CC1)C(C3)C2
Show InChI InChI=1S/C22H26F3N3O4S/c23-14-5-15(24)18(16(25)6-14)33(31,32)27-10-21(1-2-21)20(30)28-17-12-3-11-4-13(17)9-22(7-11,8-12)19(26)29/h5-6,11-13,17,27H,1-4,7-10H2,(H2,26,29)(H,28,30)/t11?,12?,13?,17-,22?
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n/an/a 9.5n/an/an/an/an/an/a



AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250434
PNG
(US9464044, 25)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CNC(=O)c4ccc(F)c(F)c4)CC1)C(C3)C2
Show InChI InChI=1S/C23H27F2N3O3/c24-16-2-1-13(7-17(16)25)19(29)27-11-22(3-4-22)21(31)28-18-14-5-12-6-15(18)10-23(8-12,9-14)20(26)30/h1-2,7,12,14-15,18H,3-6,8-11H2,(H2,26,30)(H,27,29)(H,28,31)/t12?,14?,15?,18-,23?
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n/an/a 9.60n/an/an/an/an/an/a



AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM50112153
PNG
(CHEMBL3608402 | US9464044, 83)
Show SMILES CC(C)(NS(=O)(=O)c1cc(F)cc(F)c1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O
Show InChI InChI=1S/C21H27F2N3O4S/c1-20(2,26-31(29,30)16-6-14(22)5-15(23)7-16)19(28)25-17-12-3-11-4-13(17)10-21(8-11,9-12)18(24)27/h5-7,11-13,17,26H,3-4,8-10H2,1-2H3,(H2,24,27)(H,25,28)/t11?,12?,13?,17-,21?
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n/an/a 9.90n/an/an/an/an/an/a



AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250445
PNG
(US9464044, 41)
Show SMILES Cc1c(Cl)cccc1S(=O)(=O)NC1(CC1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O
Show InChI InChI=1S/C22H28ClN3O4S/c1-12-16(23)3-2-4-17(12)31(29,30)26-22(5-6-22)20(28)25-18-14-7-13-8-15(18)11-21(9-13,10-14)19(24)27/h2-4,13-15,18,26H,5-11H2,1H3,(H2,24,27)(H,25,28)/t13?,14?,15?,18-,21?
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n/an/a 10n/an/an/an/an/an/a



AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250421
PNG
(US9464044, 11 | US9464044, 24)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CNS(=O)(=O)c4cccc(F)c4F)CC1)C(C3)C2
Show InChI InChI=1S/C22H27F2N3O4S/c23-15-2-1-3-16(17(15)24)32(30,31)26-11-21(4-5-21)20(29)27-18-13-6-12-7-14(18)10-22(8-12,9-13)19(25)28/h1-3,12-14,18,26H,4-11H2,(H2,25,28)(H,27,29)/t12?,13?,14?,18-,22?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250457
PNG
(US9464044, 59)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CC1)NC(=O)c1cccc(F)c1F)C(C3)C2
Show InChI InChI=1S/C22H25F2N3O3/c23-15-3-1-2-14(16(15)24)18(28)27-22(4-5-22)20(30)26-17-12-6-11-7-13(17)10-21(8-11,9-12)19(25)29/h1-3,11-13,17H,4-10H2,(H2,25,29)(H,26,30)(H,27,28)/t11?,12?,13?,17-,21?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250491
PNG
(US9464044, 125)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cccc(NS(=O)(=O)c4ccccc4C(F)(F)F)c1F)C(C3)C2
Show InChI InChI=1S/C25H25F4N3O4S/c26-20-16(22(33)31-21-14-8-13-9-15(21)12-24(10-13,11-14)23(30)34)4-3-6-18(20)32-37(35,36)19-7-2-1-5-17(19)25(27,28)29/h1-7,13-15,21,32H,8-12H2,(H2,30,34)(H,31,33)/t13?,14?,15?,21-,24?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250458
PNG
(US9464044, 60)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CC1)NS(=O)(=O)c1ccccc1)C(C3)C2
Show InChI InChI=1S/C21H27N3O4S/c22-18(25)20-10-13-8-14(11-20)17(15(9-13)12-20)23-19(26)21(6-7-21)24-29(27,28)16-4-2-1-3-5-16/h1-5,13-15,17,24H,6-12H2,(H2,22,25)(H,23,26)/t13?,14?,15?,17-,20?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250490
PNG
(US9464044, 123)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cccc(NS(=O)(=O)c4c(F)cccc4F)c1)C(C3)C2
Show InChI InChI=1S/C24H25F2N3O4S/c25-18-5-2-6-19(26)21(18)34(32,33)29-17-4-1-3-14(9-17)22(30)28-20-15-7-13-8-16(20)12-24(10-13,11-15)23(27)31/h1-6,9,13,15-16,20,29H,7-8,10-12H2,(H2,27,31)(H,28,30)/t13?,15?,16?,20-,24?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250470
PNG
(US9464044, 95)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cccc(NS(=O)(=O)c4cccc(Cl)c4)c1)C(C3)C2
Show InChI InChI=1S/C24H26ClN3O4S/c25-18-4-2-6-20(10-18)33(31,32)28-19-5-1-3-15(9-19)22(29)27-21-16-7-14-8-17(21)13-24(11-14,12-16)23(26)30/h1-6,9-10,14,16-17,21,28H,7-8,11-13H2,(H2,26,30)(H,27,29)/t14?,16?,17?,21-,24?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250424
PNG
(US9464044, 14)
Show SMILES Cc1cc(c(Cl)cc1Cl)S(=O)(=O)NCC1(CC1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O
Show InChI InChI=1S/C23H29Cl2N3O4S/c1-12-4-18(17(25)7-16(12)24)33(31,32)27-11-22(2-3-22)21(30)28-19-14-5-13-6-15(19)10-23(8-13,9-14)20(26)29/h4,7,13-15,19,27H,2-3,5-6,8-11H2,1H3,(H2,26,29)(H,28,30)/t13?,14?,15?,19-,23?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250414
PNG
(US9464044, 1)
Show SMILES Cc1c(Cl)cccc1S(=O)(=O)NCC1(CC1)C(=O)N[C@H]1C2CC3CC(C2)CC1C3
Show InChI InChI=1S/C22H29ClN2O3S/c1-13-18(23)3-2-4-19(13)29(27,28)24-12-22(5-6-22)21(26)25-20-16-8-14-7-15(10-16)11-17(20)9-14/h2-4,14-17,20,24H,5-12H2,1H3,(H,25,26)/t14?,15?,16?,17?,20-
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250483
PNG
(US9464044, 116)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cccc(NS(=O)(=O)c4ccc(Br)cc4Cl)c1)C(C3)C2
Show InChI InChI=1S/C24H25BrClN3O4S/c25-17-4-5-20(19(26)9-17)34(32,33)29-18-3-1-2-14(8-18)22(30)28-21-15-6-13-7-16(21)12-24(10-13,11-15)23(27)31/h1-5,8-9,13,15-16,21,29H,6-7,10-12H2,(H2,27,31)(H,28,30)/t13?,15?,16?,21-,24?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250496
PNG
(US9464044, 133)
Show SMILES COc1ccc(cc1Cl)S(=O)(=O)Nc1ccc(Cl)c(c1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O
Show InChI InChI=1S/C25H27Cl2N3O5S/c1-35-21-5-3-17(9-20(21)27)36(33,34)30-16-2-4-19(26)18(8-16)23(31)29-22-14-6-13-7-15(22)12-25(10-13,11-14)24(28)32/h2-5,8-9,13-15,22,30H,6-7,10-12H2,1H3,(H2,28,32)(H,29,31)/t13?,14?,15?,22-,25?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM50112131
PNG
(CHEMBL3608411 | US9464044, 80)
Show SMILES CC(C)(NS(=O)(=O)c1ccccc1F)C(=O)N[C@H]1C2CC3CC1CC(CC(N)=O)(C3)C2
Show InChI InChI=1S/C22H30FN3O4S/c1-21(2,26-31(29,30)17-6-4-3-5-16(17)23)20(28)25-19-14-7-13-8-15(19)11-22(9-13,10-14)12-18(24)27/h3-6,13-15,19,26H,7-12H2,1-2H3,(H2,24,27)(H,25,28)/t13?,14?,15?,19-,22?
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n/an/a 14.8n/an/an/an/an/an/a



AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250489
PNG
(US9464044, 122)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cccc(NS(=O)(=O)c4cc(F)ccc4F)c1)C(C3)C2
Show InChI InChI=1S/C24H25F2N3O4S/c25-17-4-5-19(26)20(9-17)34(32,33)29-18-3-1-2-14(8-18)22(30)28-21-15-6-13-7-16(21)12-24(10-13,11-15)23(27)31/h1-5,8-9,13,15-16,21,29H,6-7,10-12H2,(H2,27,31)(H,28,30)/t13?,15?,16?,21-,24?
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n/an/a 15.1n/an/an/an/an/an/a



AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250473
PNG
(US9464044, 100)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cccc([N-]S(=O)(=O)c4ccccc4C(F)(F)F)c1)C(C3)C2
Show InChI InChI=1S/C25H25F3N3O4S/c26-25(27,28)19-6-1-2-7-20(19)36(34,35)31-18-5-3-4-15(10-18)22(32)30-21-16-8-14-9-17(21)13-24(11-14,12-16)23(29)33/h1-7,10,14,16-17,21H,8-9,11-13H2,(H2,29,33)(H,30,32)/q-1/t14?,16?,17?,21-,24?
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n/an/a 15.3n/an/an/an/an/an/a



AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250441
PNG
(US9464044, 36)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CNS(=O)(=O)c4cc(F)c(F)cc4F)CC1)C(C3)C2
Show InChI InChI=1S/C22H26F3N3O4S/c23-14-5-16(25)17(6-15(14)24)33(31,32)27-10-21(1-2-21)20(30)28-18-12-3-11-4-13(18)9-22(7-11,8-12)19(26)29/h5-6,11-13,18,27H,1-4,7-10H2,(H2,26,29)(H,28,30)/t11?,12?,13?,18-,22?
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n/an/a 15.4n/an/an/an/an/an/a



AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250471
PNG
(US9464044, 97)
Show SMILES CN(c1cccc(c1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O)S(=O)(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C25H28ClN3O4S/c1-29(34(32,33)21-7-3-5-19(26)11-21)20-6-2-4-16(10-20)23(30)28-22-17-8-15-9-18(22)14-25(12-15,13-17)24(27)31/h2-7,10-11,15,17-18,22H,8-9,12-14H2,1H3,(H2,27,31)(H,28,30)/t15?,17?,18?,22-,25?
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n/an/a 15.6n/an/an/an/an/an/a



AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250442
PNG
(US9464044, 37)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CNS(=O)(=O)c4ccc(Cl)cc4)CC1)C(C3)C2
Show InChI InChI=1S/C22H28ClN3O4S/c23-16-1-3-17(4-2-16)31(29,30)25-12-21(5-6-21)20(28)26-18-14-7-13-8-15(18)11-22(9-13,10-14)19(24)27/h1-4,13-15,18,25H,5-12H2,(H2,24,27)(H,26,28)/t13?,14?,15?,18-,22?
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n/an/a 17.1n/an/an/an/an/an/a



AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250456
PNG
(US9464044, 58)
Show SMILES Cn1nccc1S(=O)(=O)NC1(CC1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O
Show InChI InChI=1S/C19H27N5O4S/c1-24-14(2-5-21-24)29(27,28)23-19(3-4-19)17(26)22-15-12-6-11-7-13(15)10-18(8-11,9-12)16(20)25/h2,5,11-13,15,23H,3-4,6-10H2,1H3,(H2,20,25)(H,22,26)/t11?,12?,13?,15-,18?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250429
PNG
(US9464044, 19)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CNS(=O)(=O)c4cccs4)CC1)C(C3)C2
Show InChI InChI=1S/C20H27N3O4S2/c21-17(24)20-8-12-6-13(9-20)16(14(7-12)10-20)23-18(25)19(3-4-19)11-22-29(26,27)15-2-1-5-28-15/h1-2,5,12-14,16,22H,3-4,6-11H2,(H2,21,24)(H,23,25)/t12?,13?,14?,16-,20?
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n/an/a 17.8n/an/an/an/an/an/a



AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250482
PNG
(US9464044, 115)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cccc(NS(=O)(=O)c4ccccc4C(F)(F)F)c1)C(C3)C2
Show InChI InChI=1S/C25H26F3N3O4S/c26-25(27,28)19-6-1-2-7-20(19)36(34,35)31-18-5-3-4-15(10-18)22(32)30-21-16-8-14-9-17(21)13-24(11-14,12-16)23(29)33/h1-7,10,14,16-17,21,31H,8-9,11-13H2,(H2,29,33)(H,30,32)/t14?,16?,17?,21-,24?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250485
PNG
(US9464044, 118)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cccc(NS(=O)(=O)c4cc(F)cc(Cl)c4)c1)C(C3)C2
Show InChI InChI=1S/C24H25ClFN3O4S/c25-17-7-18(26)9-20(8-17)34(32,33)29-19-3-1-2-14(6-19)22(30)28-21-15-4-13-5-16(21)12-24(10-13,11-15)23(27)31/h1-3,6-9,13,15-16,21,29H,4-5,10-12H2,(H2,27,31)(H,28,30)/t13?,15?,16?,21-,24?
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n/an/a 20.4n/an/an/an/an/an/a



AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250475
PNG
(US9464044, 103)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cccc(NS(=O)(=O)c4ccco4)c1)C(C3)C2
Show InChI InChI=1S/C22H25N3O5S/c23-21(27)22-10-13-7-15(11-22)19(16(8-13)12-22)24-20(26)14-3-1-4-17(9-14)25-31(28,29)18-5-2-6-30-18/h1-6,9,13,15-16,19,25H,7-8,10-12H2,(H2,23,27)(H,24,26)/t13?,15?,16?,19-,22?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250428
PNG
(US9464044, 18)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CNS(=O)(=O)c4cc(Cl)cc(Cl)c4)CC1)C(C3)C2
Show InChI InChI=1S/C22H27Cl2N3O4S/c23-15-5-16(24)7-17(6-15)32(30,31)26-11-21(1-2-21)20(29)27-18-13-3-12-4-14(18)10-22(8-12,9-13)19(25)28/h5-7,12-14,18,26H,1-4,8-11H2,(H2,25,28)(H,27,29)/t12?,13?,14?,18-,22?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM50112136
PNG
(CHEMBL3609864 | US9464044, 39)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CC1)NS(=O)(=O)c1ccccc1F)C(C3)C2
Show InChI InChI=1S/C21H26FN3O4S/c22-15-3-1-2-4-16(15)30(28,29)25-21(5-6-21)19(27)24-17-13-7-12-8-14(17)11-20(9-12,10-13)18(23)26/h1-4,12-14,17,25H,5-11H2,(H2,23,26)(H,24,27)/t12?,13?,14?,17-,20?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250415
PNG
(US9464044, 2)
Show SMILES OC12CC3CC(C1)[C@H](NC(=O)C1(CNS(=O)(=O)c4ccccc4F)CC1)C(C3)C2
Show InChI InChI=1S/C21H27FN2O4S/c22-16-3-1-2-4-17(16)29(27,28)23-12-20(5-6-20)19(25)24-18-14-7-13-8-15(18)11-21(26,9-13)10-14/h1-4,13-15,18,23,26H,5-12H2,(H,24,25)/t13?,14?,15?,18-,21?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250487
PNG
(US9464044, 120)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cccc(NS(=O)(=O)c4cccc(F)c4)c1)C(C3)C2
Show InChI InChI=1S/C24H26FN3O4S/c25-18-4-2-6-20(10-18)33(31,32)28-19-5-1-3-15(9-19)22(29)27-21-16-7-14-8-17(21)13-24(11-14,12-16)23(26)30/h1-6,9-10,14,16-17,21,28H,7-8,11-13H2,(H2,26,30)(H,27,29)/t14?,16?,17?,21-,24?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250425
PNG
(US9464044, 15)
Show SMILES Cc1cc(c(F)cc1Cl)S(=O)(=O)NCC1(CC1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O
Show InChI InChI=1S/C23H29ClFN3O4S/c1-12-4-18(17(25)7-16(12)24)33(31,32)27-11-22(2-3-22)21(30)28-19-14-5-13-6-15(19)10-23(8-13,9-14)20(26)29/h4,7,13-15,19,27H,2-3,5-6,8-11H2,1H3,(H2,26,29)(H,28,30)/t13?,14?,15?,19-,23?
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n/an/a 28n/an/an/an/an/an/a



AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250464
PNG
(US9464044, 69)
Show SMILES CC(C)(CNS(=O)(=O)c1ccccc1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O
Show InChI InChI=1S/C22H31N3O4S/c1-21(2,13-24-30(28,29)17-6-4-3-5-7-17)20(27)25-18-15-8-14-9-16(18)12-22(10-14,11-15)19(23)26/h3-7,14-16,18,24H,8-13H2,1-2H3,(H2,23,26)(H,25,27)/t14?,15?,16?,18-,22?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250447
PNG
(US9464044, 43)
Show SMILES Cc1cc(c(Cl)cc1Cl)S(=O)(=O)NC1(CC1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O
Show InChI InChI=1S/C22H27Cl2N3O4S/c1-11-4-17(16(24)7-15(11)23)32(30,31)27-22(2-3-22)20(29)26-18-13-5-12-6-14(18)10-21(8-12,9-13)19(25)28/h4,7,12-14,18,27H,2-3,5-6,8-10H2,1H3,(H2,25,28)(H,26,29)/t12?,13?,14?,18-,21?
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n/an/a 29.7n/an/an/an/an/an/a



AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250440
PNG
(US9464044, 34)
Show SMILES NC(=O)CCC12CC3CC(C1)[C@H](NC(=O)C1(CNS(=O)(=O)c4ccccc4F)CC1)C(C3)C2
Show InChI InChI=1S/C24H32FN3O4S/c25-18-3-1-2-4-19(18)33(31,32)27-14-24(7-8-24)22(30)28-21-16-9-15-10-17(21)13-23(11-15,12-16)6-5-20(26)29/h1-4,15-17,21,27H,5-14H2,(H2,26,29)(H,28,30)/t15?,16?,17?,21-,23?
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n/an/a 29.9n/an/an/an/an/an/a



AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250481
PNG
(US9464044, 114)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cccc(NS(=O)(=O)c4ccc(c(Cl)c4)C(F)(F)F)c1)C(C3)C2
Show InChI InChI=1S/C25H25ClF3N3O4S/c26-20-9-18(4-5-19(20)25(27,28)29)37(35,36)32-17-3-1-2-14(8-17)22(33)31-21-15-6-13-7-16(21)12-24(10-13,11-15)23(30)34/h1-5,8-9,13,15-16,21,32H,6-7,10-12H2,(H2,30,34)(H,31,33)/t13?,15?,16?,21-,24?
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n/an/a 30.7n/an/an/an/an/an/a



AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250431
PNG
(US9464044, 21)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CNS(=O)(=O)c4ccc(F)c(F)c4)CC1)C(C3)C2
Show InChI InChI=1S/C22H27F2N3O4S/c23-16-2-1-15(7-17(16)24)32(30,31)26-11-21(3-4-21)20(29)27-18-13-5-12-6-14(18)10-22(8-12,9-13)19(25)28/h1-2,7,12-14,18,26H,3-6,8-11H2,(H2,25,28)(H,27,29)/t12?,13?,14?,18-,22?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250449
PNG
(US9464044, 45)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CC1)NS(=O)(=O)c1cc(Cl)c(Cl)cc1F)C(C3)C2
Show InChI InChI=1S/C21H24Cl2FN3O4S/c22-13-5-15(24)16(6-14(13)23)32(30,31)27-21(1-2-21)19(29)26-17-11-3-10-4-12(17)9-20(7-10,8-11)18(25)28/h5-6,10-12,17,27H,1-4,7-9H2,(H2,25,28)(H,26,29)/t10?,11?,12?,17-,20?
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n/an/a 32.5n/an/an/an/an/an/a



AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM50112144
PNG
(CHEMBL3609872 | US9464044, 88)
Show SMILES CC(C)(NS(=O)(=O)c1ccc(Cl)cc1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O
Show InChI InChI=1S/C21H28ClN3O4S/c1-20(2,25-30(28,29)16-5-3-15(22)4-6-16)19(27)24-17-13-7-12-8-14(17)11-21(9-12,10-13)18(23)26/h3-6,12-14,17,25H,7-11H2,1-2H3,(H2,23,26)(H,24,27)/t12?,13?,14?,17-,21?
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n/an/a 33.8n/an/an/an/an/an/a



AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250450
PNG
(US9464044, 46)
Show SMILES Cc1cc(c(F)cc1Cl)S(=O)(=O)NC1(CC1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O
Show InChI InChI=1S/C22H27ClFN3O4S/c1-11-4-17(16(24)7-15(11)23)32(30,31)27-22(2-3-22)20(29)26-18-13-5-12-6-14(18)10-21(8-12,9-13)19(25)28/h4,7,12-14,18,27H,2-3,5-6,8-10H2,1H3,(H2,25,28)(H,26,29)/t12?,13?,14?,18-,21?
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n/an/a 34.7n/an/an/an/an/an/a



AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250494
PNG
(US9464044, 129)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cc(NS(=O)(=O)c4cc(Cl)cc(Cl)c4)ccc1Cl)C(C3)C2
Show InChI InChI=1S/C24H24Cl3N3O4S/c25-15-5-16(26)7-18(6-15)35(33,34)30-17-1-2-20(27)19(8-17)22(31)29-21-13-3-12-4-14(21)11-24(9-12,10-13)23(28)32/h1-2,5-8,12-14,21,30H,3-4,9-11H2,(H2,28,32)(H,29,31)/t12?,13?,14?,21-,24?
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n/an/a 41.8n/an/an/an/an/an/a



AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250476
PNG
(US9464044, 105)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cccc(NS(=O)(=O)c4ccccc4)c1)C(C3)C2
Show InChI InChI=1S/C24H27N3O4S/c25-23(29)24-12-15-9-17(13-24)21(18(10-15)14-24)26-22(28)16-5-4-6-19(11-16)27-32(30,31)20-7-2-1-3-8-20/h1-8,11,15,17-18,21,27H,9-10,12-14H2,(H2,25,29)(H,26,28)/t15?,17?,18?,21-,24?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250479
PNG
(US9464044, 108)
Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)Nc1cccc(c1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O
Show InChI InChI=1S/C23H29N5O4S/c1-12-20(13(2)27-26-12)33(31,32)28-18-5-3-4-15(8-18)21(29)25-19-16-6-14-7-17(19)11-23(9-14,10-16)22(24)30/h3-5,8,14,16-17,19,28H,6-7,9-11H2,1-2H3,(H2,24,30)(H,25,29)(H,26,27)/t14?,16?,17?,19-,23?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250499
PNG
(US9464044, 141)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CNC(=O)N4CCCc5ccccc45)CC1)C(C3)C2
Show InChI InChI=1S/C26H34N4O3/c27-22(31)26-12-16-10-18(13-26)21(19(11-16)14-26)29-23(32)25(7-8-25)15-28-24(33)30-9-3-5-17-4-1-2-6-20(17)30/h1-2,4,6,16,18-19,21H,3,5,7-15H2,(H2,27,31)(H,28,33)(H,29,32)/t16?,18?,19?,21-,26?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250467
PNG
(US9464044, 75)
Show SMILES CC(C)(NS(=O)(=O)c1ccccc1F)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(\N)=N/O
Show InChI InChI=1S/C21H29FN4O4S/c1-20(2,26-31(29,30)16-6-4-3-5-15(16)22)19(27)24-17-13-7-12-8-14(17)11-21(9-12,10-13)18(23)25-28/h3-6,12-14,17,26,28H,7-11H2,1-2H3,(H2,23,25)(H,24,27)/t12?,13?,14?,17-,21?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250443
PNG
(US9464044, 38)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CC1)NS(=O)(=O)c1cccc(Cl)c1)C(C3)C2
Show InChI InChI=1S/C21H26ClN3O4S/c22-15-2-1-3-16(8-15)30(28,29)25-21(4-5-21)19(27)24-17-13-6-12-7-14(17)11-20(9-12,10-13)18(23)26/h1-3,8,12-14,17,25H,4-7,9-11H2,(H2,23,26)(H,24,27)/t12?,13?,14?,17-,20?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250478
PNG
(US9464044, 107)
Show SMILES Cc1nc(C)c(s1)S(=O)(=O)Nc1cccc(c1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O
Show InChI InChI=1S/C23H28N4O4S2/c1-12-21(32-13(2)25-12)33(30,31)27-18-5-3-4-15(8-18)20(28)26-19-16-6-14-7-17(19)11-23(9-14,10-16)22(24)29/h3-5,8,14,16-17,19,27H,6-7,9-11H2,1-2H3,(H2,24,29)(H,26,28)/t14?,16?,17?,19-,23?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250497
PNG
(US9464044, 138)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cccc(NS(=O)(=O)C4CC4)c1)C(C3)C2
Show InChI InChI=1S/C21H27N3O4S/c22-20(26)21-9-12-6-14(10-21)18(15(7-12)11-21)23-19(25)13-2-1-3-16(8-13)24-29(27,28)17-4-5-17/h1-3,8,12,14-15,17-18,24H,4-7,9-11H2,(H2,22,26)(H,23,25)/t12?,14?,15?,18-,21?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250452
PNG
(US9464044, 48)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CC1)NS(=O)(=O)c1cccs1)C(C3)C2
Show InChI InChI=1S/C19H25N3O4S2/c20-16(23)18-8-11-6-12(9-18)15(13(7-11)10-18)21-17(24)19(3-4-19)22-28(25,26)14-2-1-5-27-14/h1-2,5,11-13,15,22H,3-4,6-10H2,(H2,20,23)(H,21,24)/t11?,12?,13?,15-,18?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250492
PNG
(US9464044, 126)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cc(NS(=O)(=O)c4cccc(Cl)c4)ccc1Cl)C(C3)C2
Show InChI InChI=1S/C24H25Cl2N3O4S/c25-16-2-1-3-18(8-16)34(32,33)29-17-4-5-20(26)19(9-17)22(30)28-21-14-6-13-7-15(21)12-24(10-13,11-14)23(27)31/h1-5,8-9,13-15,21,29H,6-7,10-12H2,(H2,27,31)(H,28,30)/t13?,14?,15?,21-,24?
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AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250441
PNG
(US9464044, 36)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CNS(=O)(=O)c4cc(F)c(F)cc4F)CC1)C(C3)C2
Show InChI InChI=1S/C22H26F3N3O4S/c23-14-5-16(25)17(6-15(14)24)33(31,32)27-10-21(1-2-21)20(30)28-18-12-3-11-4-13(18)9-22(7-11,8-12)19(26)29/h5-6,11-13,18,27H,1-4,7-10H2,(H2,26,29)(H,28,30)/t11?,12?,13?,18-,22?
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n/an/a 73n/an/an/an/an/an/a



AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250469
PNG
(US9464044, 94)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cccc(NS(=O)(=O)c4ccc(F)cc4)c1)C(C3)C2
Show InChI InChI=1S/C24H26FN3O4S/c25-18-4-6-20(7-5-18)33(31,32)28-19-3-1-2-15(10-19)22(29)27-21-16-8-14-9-17(21)13-24(11-14,12-16)23(26)30/h1-7,10,14,16-17,21,28H,8-9,11-13H2,(H2,26,30)(H,27,29)/t14?,16?,17?,21-,24?
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n/an/a 75.7n/an/an/an/an/an/a



AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250493
PNG
(US9464044, 127)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1ccc(F)c(NS(=O)(=O)c4cccc(Cl)c4)c1)C(C3)C2
Show InChI InChI=1S/C24H25ClFN3O4S/c25-17-2-1-3-18(9-17)34(32,33)29-20-8-14(4-5-19(20)26)22(30)28-21-15-6-13-7-16(21)12-24(10-13,11-15)23(27)31/h1-5,8-9,13,15-16,21,29H,6-7,10-12H2,(H2,27,31)(H,28,30)/t13?,15?,16?,21-,24?
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n/an/a 78.3n/an/an/an/an/an/a



AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250448
PNG
(US9464044, 44)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CC1)NS(=O)(=O)c1ccc(F)cc1F)C(C3)C2
Show InChI InChI=1S/C21H25F2N3O4S/c22-14-1-2-16(15(23)7-14)31(29,30)26-21(3-4-21)19(28)25-17-12-5-11-6-13(17)10-20(8-11,9-12)18(24)27/h1-2,7,11-13,17,26H,3-6,8-10H2,(H2,24,27)(H,25,28)/t11?,12?,13?,17-,20?
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n/an/a 79.1n/an/an/an/an/an/a



AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250498
PNG
(US9464044, 140)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CNC(=O)N4CCc5ccccc5C4)CC1)C(C3)C2
Show InChI InChI=1S/C26H34N4O3/c27-22(31)26-11-16-9-19(12-26)21(20(10-16)13-26)29-23(32)25(6-7-25)15-28-24(33)30-8-5-17-3-1-2-4-18(17)14-30/h1-4,16,19-21H,5-15H2,(H2,27,31)(H,28,33)(H,29,32)/t16?,19?,20?,21-,26?
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n/an/a 97.8n/an/an/an/an/an/a



AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250430
PNG
(US9464044, 20)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CNS(=O)(=O)c4ccc(F)cc4C(F)(F)F)CC1)C(C3)C2
Show InChI InChI=1S/C23H27F4N3O4S/c24-15-1-2-17(16(7-15)23(25,26)27)35(33,34)29-11-21(3-4-21)20(32)30-18-13-5-12-6-14(18)10-22(8-12,9-13)19(28)31/h1-2,7,12-14,18,29H,3-6,8-11H2,(H2,28,31)(H,30,32)/t12?,13?,14?,18-,22?
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n/an/a 102n/an/an/an/an/an/a



AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250462
PNG
(US9464044, 64)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CC1)NC(=O)c1ccc(cn1)C(F)(F)F)C(C3)C2
Show InChI InChI=1S/C22H25F3N4O3/c23-22(24,25)14-1-2-15(27-10-14)17(30)29-21(3-4-21)19(32)28-16-12-5-11-6-13(16)9-20(7-11,8-12)18(26)31/h1-2,10-13,16H,3-9H2,(H2,26,31)(H,28,32)(H,29,30)/t11?,12?,13?,16-,20?
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n/an/a 111n/an/an/an/an/an/a



AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250500
PNG
(US9464044, 146)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CNC(=O)N4CCNc5ccccc45)CC1)C(C3)C2
Show InChI InChI=1S/C25H33N5O3/c26-21(31)25-11-15-9-16(12-25)20(17(10-15)13-25)29-22(32)24(5-6-24)14-28-23(33)30-8-7-27-18-3-1-2-4-19(18)30/h1-4,15-17,20,27H,5-14H2,(H2,26,31)(H,28,33)(H,29,32)/t15?,16?,17?,20-,25?
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n/an/a 128n/an/an/an/an/an/a



AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250427
PNG
(US9464044, 17)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CNS(=O)(=O)c4ccco4)CC1)C(C3)C2
Show InChI InChI=1S/C20H27N3O5S/c21-17(24)20-8-12-6-13(9-20)16(14(7-12)10-20)23-18(25)19(3-4-19)11-22-29(26,27)15-2-1-5-28-15/h1-2,5,12-14,16,22H,3-4,6-11H2,(H2,21,24)(H,23,25)/t12?,13?,14?,16-,20?
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n/an/a 132n/an/an/an/an/an/a



AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250495
PNG
(US9464044, 132)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cccc(NS(=O)(=O)c4cccc(Cl)c4)c1F)C(C3)C2
Show InChI InChI=1S/C24H25ClFN3O4S/c25-16-3-1-4-17(9-16)34(32,33)29-19-6-2-5-18(20(19)26)22(30)28-21-14-7-13-8-15(21)12-24(10-13,11-14)23(27)31/h1-6,9,13-15,21,29H,7-8,10-12H2,(H2,27,31)(H,28,30)/t13?,14?,15?,21-,24?
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n/an/a 148n/an/an/an/an/an/a



AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250468
PNG
(US9464044, 92)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1ccccc1NS(=O)(=O)c1ccccc1F)C(C3)C2
Show InChI InChI=1S/C24H26FN3O4S/c25-18-6-2-4-8-20(18)33(31,32)28-19-7-3-1-5-17(19)22(29)27-21-15-9-14-10-16(21)13-24(11-14,12-15)23(26)30/h1-8,14-16,21,28H,9-13H2,(H2,26,30)(H,27,29)/t14?,15?,16?,21-,24?
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n/an/a 148n/an/an/an/an/an/a



AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250421
PNG
(US9464044, 11 | US9464044, 24)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CNS(=O)(=O)c4cccc(F)c4F)CC1)C(C3)C2
Show InChI InChI=1S/C22H27F2N3O4S/c23-15-2-1-3-16(17(15)24)32(30,31)26-11-21(4-5-21)20(29)27-18-13-6-12-7-14(18)10-22(8-12,9-13)19(25)28/h1-3,12-14,18,26H,4-11H2,(H2,25,28)(H,27,29)/t12?,13?,14?,18-,22?
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n/an/a 156n/an/an/an/an/an/a



AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250451
PNG
(US9464044, 47)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CC1)NS(=O)(=O)c1ccc(F)c(F)c1F)C(C3)C2
Show InChI InChI=1S/C21H24F3N3O4S/c22-13-1-2-14(16(24)15(13)23)32(30,31)27-21(3-4-21)19(29)26-17-11-5-10-6-12(17)9-20(7-10,8-11)18(25)28/h1-2,10-12,17,27H,3-9H2,(H2,25,28)(H,26,29)/t10?,11?,12?,17-,20?
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n/an/a 495n/an/an/an/an/an/a



AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250419
PNG
(US9464044, 9)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CNS(=O)(=O)c4cc(F)cc(F)c4)CC1)C(C3)C2
Show InChI InChI=1S/C22H27F2N3O4S/c23-15-5-16(24)7-17(6-15)32(30,31)26-11-21(1-2-21)20(29)27-18-13-3-12-4-14(18)10-22(8-12,9-13)19(25)28/h5-7,12-14,18,26H,1-4,8-11H2,(H2,25,28)(H,27,29)/t12?,13?,14?,18-,22?
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n/an/a 608n/an/an/an/an/an/a



AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM250461
PNG
(US9464044, 63)
Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CC1)NC(=O)c1ccccc1F)C(C3)C2
Show InChI InChI=1S/C22H26FN3O3/c23-16-4-2-1-3-15(16)18(27)26-22(5-6-22)20(29)25-17-13-7-12-8-14(17)11-21(9-12,10-13)19(24)28/h1-4,12-14,17H,5-11H2,(H2,24,28)(H,25,29)(H,26,27)/t12?,13?,14?,17-,21?
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n/an/a 672n/an/an/an/an/an/a



AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

US Patent


Assay Description
The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%