BindingDB logo
myBDB logout

Patent code US9464073

Compile Data Set for Download or QSAR
Found 16 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone deacetylase


(Homo sapiens (human))
BDBM249365
PNG
(US9464073, 002)
Show SMILES ONC(=O)c1cnc(NC2(CCOCC2)c2cc(F)ccc2F)nc1
Show InChI InChI=1S/C16H16F2N4O3/c17-11-1-2-13(18)12(7-11)16(3-5-25-6-4-16)21-15-19-8-10(9-20-15)14(23)22-24/h1-2,7-9,24H,3-6H2,(H,22,23)(H,19,20,21)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.40n/an/an/an/an/an/a



Acetylon Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM249364
PNG
(US9464073, 001)
Show SMILES ONC(=O)c1cnc(NC2(CCCCC2)c2cc(F)cc(F)c2)nc1
Show InChI InChI=1S/C17H18F2N4O2/c18-13-6-12(7-14(19)8-13)17(4-2-1-3-5-17)22-16-20-9-11(10-21-16)15(24)23-25/h6-10,25H,1-5H2,(H,23,24)(H,20,21,22)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.90n/an/an/an/an/an/a



Acetylon Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM249366
PNG
(US9464073, 003)
Show SMILES ONC(=O)c1cnc(NC2(CCC(F)(F)CC2)c2ccccc2)nc1
Show InChI InChI=1S/C17H18F2N4O2/c18-17(19)8-6-16(7-9-17,13-4-2-1-3-5-13)22-15-20-10-12(11-21-15)14(24)23-25/h1-5,10-11,25H,6-9H2,(H,23,24)(H,20,21,22)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.70n/an/an/an/an/an/a



Acetylon Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM249367
PNG
(US9464073, 004)
Show SMILES ONC(=O)c1cnc(NC2(CCC3(CC2)OCCO3)c2cccc(F)c2)nc1
Show InChI InChI=1S/C19H21FN4O4/c20-15-3-1-2-14(10-15)18(4-6-19(7-5-18)27-8-9-28-19)23-17-21-11-13(12-22-17)16(25)24-26/h1-3,10-12,26H,4-9H2,(H,24,25)(H,21,22,23)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.90n/an/an/an/an/an/a



Acetylon Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM249365
PNG
(US9464073, 002)
Show SMILES ONC(=O)c1cnc(NC2(CCOCC2)c2cc(F)ccc2F)nc1
Show InChI InChI=1S/C16H16F2N4O3/c17-11-1-2-13(18)12(7-11)16(3-5-25-6-4-16)21-15-19-8-10(9-20-15)14(23)22-24/h1-2,7-9,24H,3-6H2,(H,22,23)(H,19,20,21)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 108n/an/an/an/an/an/a



Acetylon Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM249365
PNG
(US9464073, 002)
Show SMILES ONC(=O)c1cnc(NC2(CCOCC2)c2cc(F)ccc2F)nc1
Show InChI InChI=1S/C16H16F2N4O3/c17-11-1-2-13(18)12(7-11)16(3-5-25-6-4-16)21-15-19-8-10(9-20-15)14(23)22-24/h1-2,7-9,24H,3-6H2,(H,22,23)(H,19,20,21)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 117n/an/an/an/an/an/a



Acetylon Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 3/NCoR1


(Homo sapiens (human))
BDBM249365
PNG
(US9464073, 002)
Show SMILES ONC(=O)c1cnc(NC2(CCOCC2)c2cc(F)ccc2F)nc1
Show InChI InChI=1S/C16H16F2N4O3/c17-11-1-2-13(18)12(7-11)16(3-5-25-6-4-16)21-15-19-8-10(9-20-15)14(23)22-24/h1-2,7-9,24H,3-6H2,(H,22,23)(H,19,20,21)
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 671n/an/an/an/an/an/a



Acetylon Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM249367
PNG
(US9464073, 004)
Show SMILES ONC(=O)c1cnc(NC2(CCC3(CC2)OCCO3)c2cccc(F)c2)nc1
Show InChI InChI=1S/C19H21FN4O4/c20-15-3-1-2-14(10-15)18(4-6-19(7-5-18)27-8-9-28-19)23-17-21-11-13(12-22-17)16(25)24-26/h1-3,10-12,26H,4-9H2,(H,24,25)(H,21,22,23)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 703n/an/an/an/an/an/a



Acetylon Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM249367
PNG
(US9464073, 004)
Show SMILES ONC(=O)c1cnc(NC2(CCC3(CC2)OCCO3)c2cccc(F)c2)nc1
Show InChI InChI=1S/C19H21FN4O4/c20-15-3-1-2-14(10-15)18(4-6-19(7-5-18)27-8-9-28-19)23-17-21-11-13(12-22-17)16(25)24-26/h1-3,10-12,26H,4-9H2,(H,24,25)(H,21,22,23)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 833n/an/an/an/an/an/a



Acetylon Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM249364
PNG
(US9464073, 001)
Show SMILES ONC(=O)c1cnc(NC2(CCCCC2)c2cc(F)cc(F)c2)nc1
Show InChI InChI=1S/C17H18F2N4O2/c18-13-6-12(7-14(19)8-13)17(4-2-1-3-5-17)22-16-20-9-11(10-21-16)15(24)23-25/h6-10,25H,1-5H2,(H,23,24)(H,20,21,22)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 870n/an/an/an/an/an/a



Acetylon Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM249366
PNG
(US9464073, 003)
Show SMILES ONC(=O)c1cnc(NC2(CCC(F)(F)CC2)c2ccccc2)nc1
Show InChI InChI=1S/C17H18F2N4O2/c18-17(19)8-6-16(7-9-17,13-4-2-1-3-5-13)22-15-20-10-12(11-21-15)14(24)23-25/h1-5,10-11,25H,6-9H2,(H,23,24)(H,20,21,22)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 961n/an/an/an/an/an/a



Acetylon Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM249366
PNG
(US9464073, 003)
Show SMILES ONC(=O)c1cnc(NC2(CCC(F)(F)CC2)c2ccccc2)nc1
Show InChI InChI=1S/C17H18F2N4O2/c18-17(19)8-6-16(7-9-17,13-4-2-1-3-5-13)22-15-20-10-12(11-21-15)14(24)23-25/h1-5,10-11,25H,6-9H2,(H,23,24)(H,20,21,22)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 982n/an/an/an/an/an/a



Acetylon Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM249364
PNG
(US9464073, 001)
Show SMILES ONC(=O)c1cnc(NC2(CCCCC2)c2cc(F)cc(F)c2)nc1
Show InChI InChI=1S/C17H18F2N4O2/c18-13-6-12(7-14(19)8-13)17(4-2-1-3-5-17)22-16-20-9-11(10-21-16)15(24)23-25/h6-10,25H,1-5H2,(H,23,24)(H,20,21,22)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.04E+3n/an/an/an/an/an/a



Acetylon Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 3/NCoR1


(Homo sapiens (human))
BDBM249367
PNG
(US9464073, 004)
Show SMILES ONC(=O)c1cnc(NC2(CCC3(CC2)OCCO3)c2cccc(F)c2)nc1
Show InChI InChI=1S/C19H21FN4O4/c20-15-3-1-2-14(10-15)18(4-6-19(7-5-18)27-8-9-28-19)23-17-21-11-13(12-22-17)16(25)24-26/h1-3,10-12,26H,4-9H2,(H,24,25)(H,21,22,23)
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.82E+3n/an/an/an/an/an/a



Acetylon Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 3/NCoR1


(Homo sapiens (human))
BDBM249366
PNG
(US9464073, 003)
Show SMILES ONC(=O)c1cnc(NC2(CCC(F)(F)CC2)c2ccccc2)nc1
Show InChI InChI=1S/C17H18F2N4O2/c18-17(19)8-6-16(7-9-17,13-4-2-1-3-5-13)22-15-20-10-12(11-21-15)14(24)23-25/h1-5,10-11,25H,6-9H2,(H,23,24)(H,20,21,22)
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.38E+3n/an/an/an/an/an/a



Acetylon Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


Citation and Details
More data for this
Ligand-Target Pair
Histone deacetylase 3/NCoR1


(Homo sapiens (human))
BDBM249364
PNG
(US9464073, 001)
Show SMILES ONC(=O)c1cnc(NC2(CCCCC2)c2cc(F)cc(F)c2)nc1
Show InChI InChI=1S/C17H18F2N4O2/c18-13-6-12(7-14(19)8-13)17(4-2-1-3-5-17)22-16-20-9-11(10-21-16)15(24)23-25/h6-10,25H,1-5H2,(H,23,24)(H,20,21,22)
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 6.20E+3n/an/an/an/an/an/a



Acetylon Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%