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Patent code US9464076

Compile Data Set for Download or QSAR
Found 131 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252902
PNG
(US9464076, 54)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(N)c4ccccc4n3)c(C)c12
Show InChI InChI=1S/C23H21N3O3S/c1-12-20-14(11-29-3)8-9-15(13(2)27)22(20)30-21(12)23(28)26-19-10-17(24)16-6-4-5-7-18(16)25-19/h4-10H,11H2,1-3H3,(H3,24,25,26,28)
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n/an/a 0.0540n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252906
PNG
(US9464076, 58)
Show SMILES COCc1ccc(C(=O)C(C)(C)C)c2sc(C(=O)Nc3cc(CN4CC[C@@H](O)C4)c4ccccc4n3)c(C)c12
Show InChI InChI=1S/C31H35N3O4S/c1-18-26-19(17-38-5)10-11-23(29(36)31(2,3)4)28(26)39-27(18)30(37)33-25-14-20(15-34-13-12-21(35)16-34)22-8-6-7-9-24(22)32-25/h6-11,14,21,35H,12-13,15-17H2,1-5H3,(H,32,33,37)/t21-/m1/s1
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252941
PNG
(US9464076, 93)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(O)=O)c(C)c12
Show InChI InChI=1S/C24H20N2O5S/c1-12-20-14(11-31-3)7-8-15(13(2)27)22(20)32-21(12)23(28)26-19-10-9-16-17(24(29)30)5-4-6-18(16)25-19/h4-10H,11H2,1-3H3,(H,29,30)(H,25,26,28)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252949
PNG
(US9464076, 101)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(=O)N3CC(O)C3)c(C)c12
Show InChI InChI=1S/C27H25N3O5S/c1-14-23-16(13-35-3)7-8-18(15(2)31)25(23)36-24(14)26(33)29-22-10-9-19-20(5-4-6-21(19)28-22)27(34)30-11-17(32)12-30/h4-10,17,32H,11-13H2,1-3H3,(H,28,29,33)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252947
PNG
(US9464076, 99)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(=O)N3CC(F)C3)c(C)c12
Show InChI InChI=1S/C27H24FN3O4S/c1-14-23-16(13-35-3)7-8-18(15(2)32)25(23)36-24(14)26(33)30-22-10-9-19-20(5-4-6-21(19)29-22)27(34)31-11-17(28)12-31/h4-10,17H,11-13H2,1-3H3,(H,29,30,33)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252961
PNG
(US9464076, 113)
Show SMILES COCc1cccc2nc(NC(=O)c3sc4c(ccc(CO)c4c3C)C(C)=O)ccc12
Show InChI InChI=1S/C24H22N2O4S/c1-13-21-15(11-27)7-8-17(14(2)28)23(21)31-22(13)24(29)26-20-10-9-18-16(12-30-3)5-4-6-19(18)25-20/h4-10,27H,11-12H2,1-3H3,(H,25,26,29)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252887
PNG
(US9464076, 116 | US9464076, 39 | US9464076, 40 | U...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CC[C@@H](O)C4)c4ccccc4n3)c(C)c12
Show InChI InChI=1S/C28H29N3O4S/c1-16-25-18(15-35-3)8-9-21(17(2)32)27(25)36-26(16)28(34)30-24-12-19(13-31-11-10-20(33)14-31)22-6-4-5-7-23(22)29-24/h4-9,12,20,33H,10-11,13-15H2,1-3H3,(H,29,30,34)/t20-/m1/s1
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252946
PNG
(US9464076, 98)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(=O)N3CCC3)c(C)c12
Show InChI InChI=1S/C27H25N3O4S/c1-15-23-17(14-34-3)8-9-18(16(2)31)25(23)35-24(15)26(32)29-22-11-10-19-20(6-4-7-21(19)28-22)27(33)30-12-5-13-30/h4,6-11H,5,12-14H2,1-3H3,(H,28,29,32)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252950
PNG
(US9464076, 102 | US9464076, 103 | US9464076, 104 |...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(=O)N3CC(C3)OC)c(C)c12
Show InChI InChI=1S/C28H27N3O5S/c1-15-24-17(14-35-3)8-9-19(16(2)32)26(24)37-25(15)27(33)30-23-11-10-20-21(6-5-7-22(20)29-23)28(34)31-12-18(13-31)36-4/h5-11,18H,12-14H2,1-4H3,(H,29,30,33)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252957
PNG
(US9464076, 109 | US9464076, 110 | US9464076, 111 |...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(CS(C)(=O)=O)cccc4n3)c(C)c12
Show InChI InChI=1S/C25H24N2O5S2/c1-14-22-16(12-32-3)8-9-18(15(2)28)24(22)33-23(14)25(29)27-21-11-10-19-17(13-34(4,30)31)6-5-7-20(19)26-21/h5-11H,12-13H2,1-4H3,(H,26,27,29)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252886
PNG
(US9464076, 38)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CC[C@H](O)C4)c4ccccc4n3)c(C)c12
Show InChI InChI=1S/C28H29N3O4S/c1-16-25-18(15-35-3)8-9-21(17(2)32)27(25)36-26(16)28(34)30-24-12-19(13-31-11-10-20(33)14-31)22-6-4-5-7-23(22)29-24/h4-9,12,20,33H,10-11,13-15H2,1-3H3,(H,29,30,34)/t20-/m0/s1
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252945
PNG
(US9464076, 97)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(=O)N(C)C)c(C)c12
Show InChI InChI=1S/C26H25N3O4S/c1-14-22-16(13-33-5)9-10-17(15(2)30)24(22)34-23(14)25(31)28-21-12-11-18-19(26(32)29(3)4)7-6-8-20(18)27-21/h6-12H,13H2,1-5H3,(H,27,28,31)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252950
PNG
(US9464076, 102 | US9464076, 103 | US9464076, 104 |...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(=O)N3CC(C3)OC)c(C)c12
Show InChI InChI=1S/C28H27N3O5S/c1-15-24-17(14-35-3)8-9-19(16(2)32)26(24)37-25(15)27(33)30-23-11-10-20-21(6-5-7-22(20)29-23)28(34)31-12-18(13-31)36-4/h5-11,18H,12-14H2,1-4H3,(H,29,30,33)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252883
PNG
(US9464076, 35)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CCC(O)C4)c4ccccc4n3)c(C)c12
Show InChI InChI=1S/C28H29N3O4S/c1-16-25-18(15-35-3)8-9-21(17(2)32)27(25)36-26(16)28(34)30-24-12-19(13-31-11-10-20(33)14-31)22-6-4-5-7-23(22)29-24/h4-9,12,20,33H,10-11,13-15H2,1-3H3,(H,29,30,34)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252950
PNG
(US9464076, 102 | US9464076, 103 | US9464076, 104 |...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(=O)N3CC(C3)OC)c(C)c12
Show InChI InChI=1S/C28H27N3O5S/c1-15-24-17(14-35-3)8-9-19(16(2)32)26(24)37-25(15)27(33)30-23-11-10-20-21(6-5-7-22(20)29-23)28(34)31-12-18(13-31)36-4/h5-11,18H,12-14H2,1-4H3,(H,29,30,33)
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Daiichi Sankyo Company, Limited

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Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252944
PNG
(US9464076, 96)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(=O)N3CCN(C)CC3)c(C)c12
Show InChI InChI=1S/C29H30N4O4S/c1-17-25-19(16-37-4)8-9-20(18(2)34)27(25)38-26(17)28(35)31-24-11-10-21-22(6-5-7-23(21)30-24)29(36)33-14-12-32(3)13-15-33/h5-11H,12-16H2,1-4H3,(H,30,31,35)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252907
PNG
(US9464076, 59)
Show SMILES COCc1ccc(C(=O)C(C)C)c2sc(C(=O)Nc3cc(CN4CC[C@@H](O)C4)c4ccccc4n3)c(C)c12
Show InChI InChI=1S/C30H33N3O4S/c1-17(2)27(35)23-10-9-19(16-37-4)26-18(3)28(38-29(23)26)30(36)32-25-13-20(14-33-12-11-21(34)15-33)22-7-5-6-8-24(22)31-25/h5-10,13,17,21,34H,11-12,14-16H2,1-4H3,(H,31,32,36)/t21-/m1/s1
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252950
PNG
(US9464076, 102 | US9464076, 103 | US9464076, 104 |...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(=O)N3CC(C3)OC)c(C)c12
Show InChI InChI=1S/C28H27N3O5S/c1-15-24-17(14-35-3)8-9-19(16(2)32)26(24)37-25(15)27(33)30-23-11-10-20-21(6-5-7-22(20)29-23)28(34)31-12-18(13-31)36-4/h5-11,18H,12-14H2,1-4H3,(H,29,30,33)
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Assay Description
Inhibitory activity-1 assay: To a solution containing 20 mM Tris-HCl (pH 7.5), 1 mM MgCl2, 100 μM EDTA, 330 μg/ml bovine serum albumin, 50 ...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252925
PNG
(US9464076, 119 | US9464076, 120 | US9464076, 77 | ...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(CO)cccc4n3)c(C)c12
Show InChI InChI=1S/C24H22N2O4S/c1-13-21-16(12-30-3)7-8-17(14(2)28)23(21)31-22(13)24(29)26-20-10-9-18-15(11-27)5-4-6-19(18)25-20/h4-10,27H,11-12H2,1-3H3,(H,25,26,29)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252887
PNG
(US9464076, 116 | US9464076, 39 | US9464076, 40 | U...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CC[C@@H](O)C4)c4ccccc4n3)c(C)c12
Show InChI InChI=1S/C28H29N3O4S/c1-16-25-18(15-35-3)8-9-21(17(2)32)27(25)36-26(16)28(34)30-24-12-19(13-31-11-10-20(33)14-31)22-6-4-5-7-23(22)29-24/h4-9,12,20,33H,10-11,13-15H2,1-3H3,(H,29,30,34)/t20-/m1/s1
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252884
PNG
(US9464076, 36)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CCC(O)CC4)c4ccccc4n3)c(C)c12
Show InChI InChI=1S/C29H31N3O4S/c1-17-26-19(16-36-3)8-9-22(18(2)33)28(26)37-27(17)29(35)31-25-14-20(15-32-12-10-21(34)11-13-32)23-6-4-5-7-24(23)30-25/h4-9,14,21,34H,10-13,15-16H2,1-3H3,(H,30,31,35)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252937
PNG
(US9464076, 89)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(COC(=O)CCC(O)=O)cccc4n3)c(C)c12
Show InChI InChI=1S/C28H26N2O7S/c1-15-25-18(13-36-3)7-8-19(16(2)31)27(25)38-26(15)28(35)30-22-10-9-20-17(5-4-6-21(20)29-22)14-37-24(34)12-11-23(32)33/h4-10H,11-14H2,1-3H3,(H,32,33)(H,29,30,35)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252915
PNG
(US9464076, 117 | US9464076, 118 | US9464076, 67 | ...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(COC)cccc4n3)c(C)c12
Show InChI InChI=1S/C25H24N2O4S/c1-14-22-17(13-31-4)8-9-18(15(2)28)24(22)32-23(14)25(29)27-21-11-10-19-16(12-30-3)6-5-7-20(19)26-21/h5-11H,12-13H2,1-4H3,(H,26,27,29)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252913
PNG
(US9464076, 65)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(CN5CC(O)C5)cccc4n3)c(C)c12
Show InChI InChI=1S/C27H27N3O4S/c1-15-24-18(14-34-3)7-8-20(16(2)31)26(24)35-25(15)27(33)29-23-10-9-21-17(5-4-6-22(21)28-23)11-30-12-19(32)13-30/h4-10,19,32H,11-14H2,1-3H3,(H,28,29,33)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252887
PNG
(US9464076, 116 | US9464076, 39 | US9464076, 40 | U...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CC[C@@H](O)C4)c4ccccc4n3)c(C)c12
Show InChI InChI=1S/C28H29N3O4S/c1-16-25-18(15-35-3)8-9-21(17(2)32)27(25)36-26(16)28(34)30-24-12-19(13-31-11-10-20(33)14-31)22-6-4-5-7-23(22)29-24/h4-9,12,20,33H,10-11,13-15H2,1-3H3,(H,29,30,34)/t20-/m1/s1
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
Inhibitory activity-1 assay: To a solution containing 20 mM Tris-HCl (pH 7.5), 1 mM MgCl2, 100 μM EDTA, 330 μg/ml bovine serum albumin, 50 ...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252948
PNG
(US9464076, 100)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(=O)N3CC(F)(F)C3)c(C)c12
Show InChI InChI=1S/C27H23F2N3O4S/c1-14-22-16(11-36-3)7-8-17(15(2)33)24(22)37-23(14)25(34)31-21-10-9-18-19(5-4-6-20(18)30-21)26(35)32-12-27(28,29)13-32/h4-10H,11-13H2,1-3H3,(H,30,31,34)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252886
PNG
(US9464076, 38)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CC[C@H](O)C4)c4ccccc4n3)c(C)c12
Show InChI InChI=1S/C28H29N3O4S/c1-16-25-18(15-35-3)8-9-21(17(2)32)27(25)36-26(16)28(34)30-24-12-19(13-31-11-10-20(33)14-31)22-6-4-5-7-23(22)29-24/h4-9,12,20,33H,10-11,13-15H2,1-3H3,(H,29,30,34)/t20-/m0/s1
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
Inhibitory activity-1 assay: To a solution containing 20 mM Tris-HCl (pH 7.5), 1 mM MgCl2, 100 μM EDTA, 330 μg/ml bovine serum albumin, 50 ...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252894
PNG
(US9464076, 46)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CCC(F)CC4)c4ccccc4n3)c(C)c12
Show InChI InChI=1S/C29H30FN3O3S/c1-17-26-19(16-36-3)8-9-22(18(2)34)28(26)37-27(17)29(35)32-25-14-20(15-33-12-10-21(30)11-13-33)23-6-4-5-7-24(23)31-25/h4-9,14,21H,10-13,15-16H2,1-3H3,(H,31,32,35)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252903
PNG
(US9464076, 55)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(N(C)C)c4ccccc4n3)c(C)c12
Show InChI InChI=1S/C25H25N3O3S/c1-14-22-16(13-31-5)10-11-17(15(2)29)24(22)32-23(14)25(30)27-21-12-20(28(3)4)18-8-6-7-9-19(18)26-21/h6-12H,13H2,1-5H3,(H,26,27,30)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252866
PNG
(US9464076, 18)
Show SMILES CC(C)C(=O)c1cccc2c(C)c(sc12)C(=O)Nc1cc(c2ccccc2n1)C(C)(C)O
Show InChI InChI=1S/C26H26N2O3S/c1-14(2)22(29)18-11-8-10-16-15(3)23(32-24(16)18)25(30)28-21-13-19(26(4,5)31)17-9-6-7-12-20(17)27-21/h6-14,31H,1-5H3,(H,27,28,30)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252943
PNG
(US9464076, 95)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(=O)N3CCOCC3)c(C)c12
Show InChI InChI=1S/C28H27N3O5S/c1-16-24-18(15-35-3)7-8-19(17(2)32)26(24)37-25(16)27(33)30-23-10-9-20-21(5-4-6-22(20)29-23)28(34)31-11-13-36-14-12-31/h4-10H,11-15H2,1-3H3,(H,29,30,33)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252895
PNG
(US9464076, 47)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CC(O)C4)c4ccccc4n3)c(C)c12
Show InChI InChI=1S/C27H27N3O4S/c1-15-24-17(14-34-3)8-9-20(16(2)31)26(24)35-25(15)27(33)29-23-10-18(11-30-12-19(32)13-30)21-6-4-5-7-22(21)28-23/h4-10,19,32H,11-14H2,1-3H3,(H,28,29,33)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252885
PNG
(US9464076, 37)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CCCC(O)C4)c4ccccc4n3)c(C)c12
Show InChI InChI=1S/C29H31N3O4S/c1-17-26-19(16-36-3)10-11-22(18(2)33)28(26)37-27(17)29(35)31-25-13-20(14-32-12-6-7-21(34)15-32)23-8-4-5-9-24(23)30-25/h4-5,8-11,13,21,34H,6-7,12,14-16H2,1-3H3,(H,30,31,35)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252950
PNG
(US9464076, 102 | US9464076, 103 | US9464076, 104 |...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(=O)N3CC(C3)OC)c(C)c12
Show InChI InChI=1S/C28H27N3O5S/c1-15-24-17(14-35-3)8-9-19(16(2)32)26(24)37-25(15)27(33)30-23-11-10-20-21(6-5-7-22(20)29-23)28(34)31-12-18(13-31)36-4/h5-11,18H,12-14H2,1-4H3,(H,29,30,33)
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Daiichi Sankyo Company, Limited

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Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252893
PNG
(US9464076, 45)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CC[C@@H](F)C4)c4ccccc4n3)c(C)c12
Show InChI InChI=1S/C28H28FN3O3S/c1-16-25-18(15-35-3)8-9-21(17(2)33)27(25)36-26(16)28(34)31-24-12-19(13-32-11-10-20(29)14-32)22-6-4-5-7-23(22)30-24/h4-9,12,20H,10-11,13-15H2,1-3H3,(H,30,31,34)/t20-/m1/s1
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Daiichi Sankyo Company, Limited

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Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252924
PNG
(US9464076, 76)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(C)O)c(C)c12
Show InChI InChI=1S/C25H24N2O4S/c1-13-22-16(12-31-4)8-9-18(15(3)29)24(22)32-23(13)25(30)27-21-11-10-19-17(14(2)28)6-5-7-20(19)26-21/h5-11,14,28H,12H2,1-4H3,(H,26,27,30)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252920
PNG
(US9464076, 72)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(COCCO)cccc4n3)c(C)c12
Show InChI InChI=1S/C26H26N2O5S/c1-15-23-18(13-32-3)7-8-19(16(2)30)25(23)34-24(15)26(31)28-22-10-9-20-17(14-33-12-11-29)5-4-6-21(20)27-22/h4-10,29H,11-14H2,1-3H3,(H,27,28,31)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252950
PNG
(US9464076, 102 | US9464076, 103 | US9464076, 104 |...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(=O)N3CC(C3)OC)c(C)c12
Show InChI InChI=1S/C28H27N3O5S/c1-15-24-17(14-35-3)8-9-19(16(2)32)26(24)37-25(15)27(33)30-23-11-10-20-21(6-5-7-22(20)29-23)28(34)31-12-18(13-31)36-4/h5-11,18H,12-14H2,1-4H3,(H,29,30,33)
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Daiichi Sankyo Company, Limited

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Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252935
PNG
(US9464076, 87)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(COP(O)(O)=O)cccc4n3)c(C)c12
Show InChI InChI=1S/C24H23N2O7PS/c1-13-21-16(11-32-3)7-8-17(14(2)27)23(21)35-22(13)24(28)26-20-10-9-18-15(12-33-34(29,30)31)5-4-6-19(18)25-20/h4-10H,11-12H2,1-3H3,(H,25,26,28)(H2,29,30,31)
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Daiichi Sankyo Company, Limited

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Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252957
PNG
(US9464076, 109 | US9464076, 110 | US9464076, 111 |...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(CS(C)(=O)=O)cccc4n3)c(C)c12
Show InChI InChI=1S/C25H24N2O5S2/c1-14-22-16(12-32-3)8-9-18(15(2)28)24(22)33-23(14)25(29)27-21-11-10-19-17(13-34(4,30)31)6-5-7-20(19)26-21/h5-11H,12-13H2,1-4H3,(H,26,27,29)
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Daiichi Sankyo Company, Limited

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Assay Description
Inhibitory activity-1 assay: To a solution containing 20 mM Tris-HCl (pH 7.5), 1 mM MgCl2, 100 μM EDTA, 330 μg/ml bovine serum albumin, 50 ...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252915
PNG
(US9464076, 117 | US9464076, 118 | US9464076, 67 | ...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(COC)cccc4n3)c(C)c12
Show InChI InChI=1S/C25H24N2O4S/c1-14-22-17(13-31-4)8-9-18(15(2)28)24(22)32-23(14)25(29)27-21-11-10-19-16(12-30-3)6-5-7-20(19)26-21/h5-11H,12-13H2,1-4H3,(H,26,27,29)
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Daiichi Sankyo Company, Limited

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Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252925
PNG
(US9464076, 119 | US9464076, 120 | US9464076, 77 | ...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(CO)cccc4n3)c(C)c12
Show InChI InChI=1S/C24H22N2O4S/c1-13-21-16(12-30-3)7-8-17(14(2)28)23(21)31-22(13)24(29)26-20-10-9-18-15(11-27)5-4-6-19(18)25-20/h4-10,27H,11-12H2,1-3H3,(H,25,26,29)
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Daiichi Sankyo Company, Limited

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Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252887
PNG
(US9464076, 116 | US9464076, 39 | US9464076, 40 | U...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CC[C@@H](O)C4)c4ccccc4n3)c(C)c12
Show InChI InChI=1S/C28H29N3O4S/c1-16-25-18(15-35-3)8-9-21(17(2)32)27(25)36-26(16)28(34)30-24-12-19(13-31-11-10-20(33)14-31)22-6-4-5-7-23(22)29-24/h4-9,12,20,33H,10-11,13-15H2,1-3H3,(H,29,30,34)/t20-/m1/s1
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
Inhibitory activity-1 assay: To a solution containing 20 mM Tris-HCl (pH 7.5), 1 mM MgCl2, 100 μM EDTA, 330 μg/ml bovine serum albumin, 50 ...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252869
PNG
(US9464076, 21)
Show SMILES Cc1c(sc2c(cccc12)C(=O)C1CCC1)C(=O)Nc1cc(c2ccccc2n1)C(C)(C)O
Show InChI InChI=1S/C27H26N2O3S/c1-15-17-11-7-12-19(23(30)16-8-6-9-16)25(17)33-24(15)26(31)29-22-14-20(27(2,3)32)18-10-4-5-13-21(18)28-22/h4-5,7,10-14,16,32H,6,8-9H2,1-3H3,(H,28,29,31)
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Daiichi Sankyo Company, Limited

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Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252950
PNG
(US9464076, 102 | US9464076, 103 | US9464076, 104 |...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(=O)N3CC(C3)OC)c(C)c12
Show InChI InChI=1S/C28H27N3O5S/c1-15-24-17(14-35-3)8-9-19(16(2)32)26(24)37-25(15)27(33)30-23-11-10-20-21(6-5-7-22(20)29-23)28(34)31-12-18(13-31)36-4/h5-11,18H,12-14H2,1-4H3,(H,29,30,33)
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Assay Description
Inhibitory activity-1 assay: To a solution containing 20 mM Tris-HCl (pH 7.5), 1 mM MgCl2, 100 μM EDTA, 330 μg/ml bovine serum albumin, 50 ...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252950
PNG
(US9464076, 102 | US9464076, 103 | US9464076, 104 |...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(=O)N3CC(C3)OC)c(C)c12
Show InChI InChI=1S/C28H27N3O5S/c1-15-24-17(14-35-3)8-9-19(16(2)32)26(24)37-25(15)27(33)30-23-11-10-20-21(6-5-7-22(20)29-23)28(34)31-12-18(13-31)36-4/h5-11,18H,12-14H2,1-4H3,(H,29,30,33)
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Assay Description
Inhibitory activity-1 assay: To a solution containing 20 mM Tris-HCl (pH 7.5), 1 mM MgCl2, 100 μM EDTA, 330 μg/ml bovine serum albumin, 50 ...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252939
PNG
(US9464076, 91)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(COC(=O)[C@@H](N)CO)cccc4n3)c(C)c12
Show InChI InChI=1S/C27H27N3O6S/c1-14-23-17(12-35-3)7-8-18(15(2)32)25(23)37-24(14)26(33)30-22-10-9-19-16(5-4-6-21(19)29-22)13-36-27(34)20(28)11-31/h4-10,20,31H,11-13,28H2,1-3H3,(H,29,30,33)/t20-/m0/s1
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Daiichi Sankyo Company, Limited

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Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252919
PNG
(US9464076, 71)
Show SMILES COCCOCc1cccc2nc(NC(=O)c3sc4c(ccc(COC)c4c3C)C(C)=O)ccc12
Show InChI InChI=1S/C27H28N2O5S/c1-16-24-19(14-33-4)8-9-20(17(2)30)26(24)35-25(16)27(31)29-23-11-10-21-18(15-34-13-12-32-3)6-5-7-22(21)28-23/h5-11H,12-15H2,1-4H3,(H,28,29,31)
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Daiichi Sankyo Company, Limited

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Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252915
PNG
(US9464076, 117 | US9464076, 118 | US9464076, 67 | ...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(COC)cccc4n3)c(C)c12
Show InChI InChI=1S/C25H24N2O4S/c1-14-22-17(13-31-4)8-9-18(15(2)28)24(22)32-23(14)25(29)27-21-11-10-19-16(12-30-3)6-5-7-20(19)26-21/h5-11H,12-13H2,1-4H3,(H,26,27,29)
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Daiichi Sankyo Company, Limited

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Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252912
PNG
(US9464076, 64)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(CN5CC[C@@H](O)C5)cccc4n3)c(C)c12
Show InChI InChI=1S/C28H29N3O4S/c1-16-25-19(15-35-3)7-8-21(17(2)32)27(25)36-26(16)28(34)30-24-10-9-22-18(5-4-6-23(22)29-24)13-31-12-11-20(33)14-31/h4-10,20,33H,11-15H2,1-3H3,(H,29,30,34)/t20-/m1/s1
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Daiichi Sankyo Company, Limited

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Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252969
PNG
(US9464076, 125)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CCN(C)CC4)c4ccccc4n3)c(C)c12
Show InChI InChI=1S/C29H32N4O3S/c1-18-26-20(17-36-4)9-10-22(19(2)34)28(26)37-27(18)29(35)31-25-15-21(16-33-13-11-32(3)12-14-33)23-7-5-6-8-24(23)30-25/h5-10,15H,11-14,16-17H2,1-4H3,(H,30,31,35)
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Daiichi Sankyo Company, Limited

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Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252925
PNG
(US9464076, 119 | US9464076, 120 | US9464076, 77 | ...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(CO)cccc4n3)c(C)c12
Show InChI InChI=1S/C24H22N2O4S/c1-13-21-16(12-30-3)7-8-17(14(2)28)23(21)31-22(13)24(29)26-20-10-9-18-15(11-27)5-4-6-19(18)25-20/h4-10,27H,11-12H2,1-3H3,(H,25,26,29)
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Daiichi Sankyo Company, Limited

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Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252957
PNG
(US9464076, 109 | US9464076, 110 | US9464076, 111 |...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(CS(C)(=O)=O)cccc4n3)c(C)c12
Show InChI InChI=1S/C25H24N2O5S2/c1-14-22-16(12-32-3)8-9-18(15(2)28)24(22)33-23(14)25(29)27-21-11-10-19-17(13-34(4,30)31)6-5-7-20(19)26-21/h5-11H,12-13H2,1-4H3,(H,26,27,29)
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Daiichi Sankyo Company, Limited

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Assay Description
Inhibitory activity-1 assay: To a solution containing 20 mM Tris-HCl (pH 7.5), 1 mM MgCl2, 100 μM EDTA, 330 μg/ml bovine serum albumin, 50 ...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252896
PNG
(US9464076, 48)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CCC(F)(F)C4)c4ccccc4n3)c(C)c12
Show InChI InChI=1S/C28H27F2N3O3S/c1-16-24-18(14-36-3)8-9-20(17(2)34)26(24)37-25(16)27(35)32-23-12-19(13-33-11-10-28(29,30)15-33)21-6-4-5-7-22(21)31-23/h4-9,12H,10-11,13-15H2,1-3H3,(H,31,32,35)
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Daiichi Sankyo Company, Limited

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Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252931
PNG
(US9464076, 83)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(COC(C)=O)cccc4n3)c(C)c12
Show InChI InChI=1S/C26H24N2O5S/c1-14-23-18(12-32-4)8-9-19(15(2)29)25(23)34-24(14)26(31)28-22-11-10-20-17(13-33-16(3)30)6-5-7-21(20)27-22/h5-11H,12-13H2,1-4H3,(H,27,28,31)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252925
PNG
(US9464076, 119 | US9464076, 120 | US9464076, 77 | ...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(CO)cccc4n3)c(C)c12
Show InChI InChI=1S/C24H22N2O4S/c1-13-21-16(12-30-3)7-8-17(14(2)28)23(21)31-22(13)24(29)26-20-10-9-18-15(11-27)5-4-6-19(18)25-20/h4-10,27H,11-12H2,1-3H3,(H,25,26,29)
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Daiichi Sankyo Company, Limited

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Assay Description
Inhibitory activity-1 assay: To a solution containing 20 mM Tris-HCl (pH 7.5), 1 mM MgCl2, 100 μM EDTA, 330 μg/ml bovine serum albumin, 50 ...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252963
PNG
(US9464076, 115)
Show SMILES COC1CN(C1)C(=O)c1cccc2nc(NC(=O)c3sc4c(ccc(CO)c4c3C)C(C)=O)ccc12
Show InChI InChI=1S/C27H25N3O5S/c1-14-23-16(13-31)7-8-18(15(2)32)25(23)36-24(14)26(33)29-22-10-9-19-20(5-4-6-21(19)28-22)27(34)30-11-17(12-30)35-3/h4-10,17,31H,11-13H2,1-3H3,(H,28,29,33)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252862
PNG
(US9464076, 14)
Show SMILES CC(=O)c1ccc(C(C)=O)c2c(C)c(sc12)C(=O)Nc1cc(CO)c2ccccc2n1
Show InChI InChI=1S/C24H20N2O4S/c1-12-21-16(13(2)28)8-9-17(14(3)29)23(21)31-22(12)24(30)26-20-10-15(11-27)18-6-4-5-7-19(18)25-20/h4-10,27H,11H2,1-3H3,(H,25,26,30)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252881
PNG
(US9464076, 33)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(C(C)O)c4ccccc4n3)c(C)c12
Show InChI InChI=1S/C25H24N2O4S/c1-13-22-16(12-31-4)9-10-17(14(2)28)24(22)32-23(13)25(30)27-21-11-19(15(3)29)18-7-5-6-8-20(18)26-21/h5-11,15,29H,12H2,1-4H3,(H,26,27,30)
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Daiichi Sankyo Company, Limited

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Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252923
PNG
(US9464076, 75)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(C)=O)c(C)c12
Show InChI InChI=1S/C25H22N2O4S/c1-13-22-16(12-31-4)8-9-18(15(3)29)24(22)32-23(13)25(30)27-21-11-10-19-17(14(2)28)6-5-7-20(19)26-21/h5-11H,12H2,1-4H3,(H,26,27,30)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252867
PNG
(US9464076, 19)
Show SMILES Cc1c(sc2c(cccc12)C(=O)C1CC1)C(=O)Nc1cc(c2ccccc2n1)C(C)(C)O
Show InChI InChI=1S/C26H24N2O3S/c1-14-16-8-6-9-18(22(29)15-11-12-15)24(16)32-23(14)25(30)28-21-13-19(26(2,3)31)17-7-4-5-10-20(17)27-21/h4-10,13,15,31H,11-12H2,1-3H3,(H,27,28,30)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252890
PNG
(US9464076, 42)
Show SMILES CCc1c(sc2c(ccc(COC)c12)C(C)=O)C(=O)Nc1cc(CN2CC[C@@H](O)C2)c2ccccc2n1
Show InChI InChI=1S/C29H31N3O4S/c1-4-21-26-18(16-36-3)9-10-22(17(2)33)27(26)37-28(21)29(35)31-25-13-19(14-32-12-11-20(34)15-32)23-7-5-6-8-24(23)30-25/h5-10,13,20,34H,4,11-12,14-16H2,1-3H3,(H,30,31,35)/t20-/m1/s1
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Daiichi Sankyo Company, Limited

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Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252915
PNG
(US9464076, 117 | US9464076, 118 | US9464076, 67 | ...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(COC)cccc4n3)c(C)c12
Show InChI InChI=1S/C25H24N2O4S/c1-14-22-17(13-31-4)8-9-18(15(2)28)24(22)32-23(14)25(29)27-21-11-10-19-16(12-30-3)6-5-7-20(19)26-21/h5-11H,12-13H2,1-4H3,(H,26,27,29)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252882
PNG
(US9464076, 34)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN(C)CCO)c4ccccc4n3)c(C)c12
Show InChI InChI=1S/C27H29N3O4S/c1-16-24-18(15-34-4)9-10-20(17(2)32)26(24)35-25(16)27(33)29-23-13-19(14-30(3)11-12-31)21-7-5-6-8-22(21)28-23/h5-10,13,31H,11-12,14-15H2,1-4H3,(H,28,29,33)
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Daiichi Sankyo Company, Limited

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Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252936
PNG
(US9464076, 88)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(COP([O-])([O-])=O)cccc4n3)c(C)c12
Show InChI InChI=1S/C24H23N2O7PS/c1-13-21-16(11-32-3)7-8-17(14(2)27)23(21)35-22(13)24(28)26-20-10-9-18-15(12-33-34(29,30)31)5-4-6-19(18)25-20/h4-10H,11-12H2,1-3H3,(H,25,26,28)(H2,29,30,31)/p-2
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Assay Description
Inhibitory activity-1 assay: To a solution containing 20 mM Tris-HCl (pH 7.5), 1 mM MgCl2, 100 μM EDTA, 330 μg/ml bovine serum albumin, 50 ...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252870
PNG
(US9464076, 22)
Show SMILES Cc1c(sc2c(cccc12)C(=O)C(C)(C)C)C(=O)Nc1cc(c2ccccc2n1)C(C)(C)O
Show InChI InChI=1S/C27H28N2O3S/c1-15-16-11-9-12-18(24(30)26(2,3)4)23(16)33-22(15)25(31)29-21-14-19(27(5,6)32)17-10-7-8-13-20(17)28-21/h7-14,32H,1-6H3,(H,28,29,31)
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Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252938
PNG
(US9464076, 90)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(COC(=O)CCC([O-])=O)cccc4n3)c(C)c12
Show InChI InChI=1S/C28H26N2O7S/c1-15-25-18(13-36-3)7-8-19(16(2)31)27(25)38-26(15)28(35)30-22-10-9-20-17(5-4-6-21(20)29-22)14-37-24(34)12-11-23(32)33/h4-10H,11-14H2,1-3H3,(H,32,33)(H,29,30,35)/p-1
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Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252925
PNG
(US9464076, 119 | US9464076, 120 | US9464076, 77 | ...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(CO)cccc4n3)c(C)c12
Show InChI InChI=1S/C24H22N2O4S/c1-13-21-16(12-30-3)7-8-17(14(2)28)23(21)31-22(13)24(29)26-20-10-9-18-15(11-27)5-4-6-19(18)25-20/h4-10,27H,11-12H2,1-3H3,(H,25,26,29)
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Assay Description
Inhibitory activity-1 assay: To a solution containing 20 mM Tris-HCl (pH 7.5), 1 mM MgCl2, 100 μM EDTA, 330 μg/ml bovine serum albumin, 50 ...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252897
PNG
(US9464076, 49)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4ccccc4n3)c(C)c12
Show InChI InChI=1S/C23H20N2O3S/c1-13-20-16(12-28-3)8-10-17(14(2)26)22(20)29-21(13)23(27)25-19-11-9-15-6-4-5-7-18(15)24-19/h4-11H,12H2,1-3H3,(H,24,25,27)
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Daiichi Sankyo Company, Limited

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Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252933
PNG
(US9464076, 85)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(COC(=O)CN)cccc4n3)c(C)c12
Show InChI InChI=1S/C26H25N3O5S/c1-14-23-17(12-33-3)7-8-18(15(2)30)25(23)35-24(14)26(32)29-21-10-9-19-16(13-34-22(31)11-27)5-4-6-20(19)28-21/h4-10H,11-13,27H2,1-3H3,(H,28,29,32)
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Daiichi Sankyo Company, Limited

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Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252911
PNG
(US9464076, 63)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(CN5CC[C@H](O)C5)cccc4n3)c(C)c12
Show InChI InChI=1S/C28H29N3O4S/c1-16-25-19(15-35-3)7-8-21(17(2)32)27(25)36-26(16)28(34)30-24-10-9-22-18(5-4-6-23(22)29-24)13-31-12-11-20(33)14-31/h4-10,20,33H,11-15H2,1-3H3,(H,29,30,34)/t20-/m0/s1
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Daiichi Sankyo Company, Limited

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Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252934
PNG
(US9464076, 86)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(COC(=O)[C@H](C)N)cccc4n3)c(C)c12
Show InChI InChI=1S/C27H27N3O5S/c1-14-23-18(12-34-4)8-9-19(16(3)31)25(23)36-24(14)26(32)30-22-11-10-20-17(6-5-7-21(20)29-22)13-35-27(33)15(2)28/h5-11,15H,12-13,28H2,1-4H3,(H,29,30,32)/t15-/m0/s1
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Daiichi Sankyo Company, Limited

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Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252957
PNG
(US9464076, 109 | US9464076, 110 | US9464076, 111 |...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(CS(C)(=O)=O)cccc4n3)c(C)c12
Show InChI InChI=1S/C25H24N2O5S2/c1-14-22-16(12-32-3)8-9-18(15(2)28)24(22)33-23(14)25(29)27-21-11-10-19-17(13-34(4,30)31)6-5-7-20(19)26-21/h5-11H,12-13H2,1-4H3,(H,26,27,29)
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Assay Description
Inhibitory activity-1 assay: To a solution containing 20 mM Tris-HCl (pH 7.5), 1 mM MgCl2, 100 μM EDTA, 330 μg/ml bovine serum albumin, 50 ...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252904
PNG
(US9464076, 56)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(N4CCOCC4)c4ccccc4n3)c(C)c12
Show InChI InChI=1S/C27H27N3O4S/c1-16-24-18(15-33-3)8-9-19(17(2)31)26(24)35-25(16)27(32)29-23-14-22(30-10-12-34-13-11-30)20-6-4-5-7-21(20)28-23/h4-9,14H,10-13,15H2,1-3H3,(H,28,29,32)
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Daiichi Sankyo Company, Limited

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Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252914
PNG
(US9464076, 66)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(CN5CC(C5)OC)cccc4n3)c(C)c12
Show InChI InChI=1S/C28H29N3O4S/c1-16-25-19(15-34-3)8-9-21(17(2)32)27(25)36-26(16)28(33)30-24-11-10-22-18(6-5-7-23(22)29-24)12-31-13-20(14-31)35-4/h5-11,20H,12-15H2,1-4H3,(H,29,30,33)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252908
PNG
(US9464076, 60)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(CN5CC[C@@H](F)C5)cccc4n3)c(C)c12
Show InChI InChI=1S/C28H28FN3O3S/c1-16-25-19(15-35-3)7-8-21(17(2)33)27(25)36-26(16)28(34)31-24-10-9-22-18(5-4-6-23(22)30-24)13-32-12-11-20(29)14-32/h4-10,20H,11-15H2,1-3H3,(H,30,31,34)/t20-/m1/s1
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Daiichi Sankyo Company, Limited

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Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252900
PNG
(US9464076, 52)
Show SMILES CC(=O)c1ccc(C(C)=O)c2c(C)c(sc12)C(=O)Nc1cc(CN2CC(O)C2)c2ccccc2n1
Show InChI InChI=1S/C27H25N3O4S/c1-14-24-19(15(2)31)8-9-20(16(3)32)26(24)35-25(14)27(34)29-23-10-17(11-30-12-18(33)13-30)21-6-4-5-7-22(21)28-23/h4-10,18,33H,11-13H2,1-3H3,(H,28,29,34)
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Daiichi Sankyo Company, Limited

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Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252942
PNG
(US9464076, 94)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(=O)NN3CCCC3)c(C)c12
Show InChI InChI=1S/C28H28N4O4S/c1-16-24-18(15-36-3)9-10-19(17(2)33)26(24)37-25(16)28(35)30-23-12-11-20-21(7-6-8-22(20)29-23)27(34)31-32-13-4-5-14-32/h6-12H,4-5,13-15H2,1-3H3,(H,31,34)(H,29,30,35)
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Daiichi Sankyo Company, Limited

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Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252909
PNG
(US9464076, 61)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(CN5CCOCC5)cccc4n3)c(C)c12
Show InChI InChI=1S/C28H29N3O4S/c1-17-25-20(16-34-3)7-8-21(18(2)32)27(25)36-26(17)28(33)30-24-10-9-22-19(5-4-6-23(22)29-24)15-31-11-13-35-14-12-31/h4-10H,11-16H2,1-3H3,(H,29,30,33)
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Daiichi Sankyo Company, Limited

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Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252887
PNG
(US9464076, 116 | US9464076, 39 | US9464076, 40 | U...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CC[C@@H](O)C4)c4ccccc4n3)c(C)c12
Show InChI InChI=1S/C28H29N3O4S/c1-16-25-18(15-35-3)8-9-21(17(2)32)27(25)36-26(16)28(34)30-24-12-19(13-31-11-10-20(33)14-31)22-6-4-5-7-23(22)29-24/h4-9,12,20,33H,10-11,13-15H2,1-3H3,(H,29,30,34)/t20-/m1/s1
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Daiichi Sankyo Company, Limited

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Assay Description
Inhibitory activity-1 assay: To a solution containing 20 mM Tris-HCl (pH 7.5), 1 mM MgCl2, 100 μM EDTA, 330 μg/ml bovine serum albumin, 50 ...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252957
PNG
(US9464076, 109 | US9464076, 110 | US9464076, 111 |...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(CS(C)(=O)=O)cccc4n3)c(C)c12
Show InChI InChI=1S/C25H24N2O5S2/c1-14-22-16(12-32-3)8-9-18(15(2)28)24(22)33-23(14)25(29)27-21-11-10-19-17(13-34(4,30)31)6-5-7-20(19)26-21/h5-11H,12-13H2,1-4H3,(H,26,27,29)
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Daiichi Sankyo Company, Limited

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Assay Description
Inhibitory activity-1 assay: To a solution containing 20 mM Tris-HCl (pH 7.5), 1 mM MgCl2, 100 μM EDTA, 330 μg/ml bovine serum albumin, 50 ...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252925
PNG
(US9464076, 119 | US9464076, 120 | US9464076, 77 | ...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(CO)cccc4n3)c(C)c12
Show InChI InChI=1S/C24H22N2O4S/c1-13-21-16(12-30-3)7-8-17(14(2)28)23(21)31-22(13)24(29)26-20-10-9-18-15(11-27)5-4-6-19(18)25-20/h4-10,27H,11-12H2,1-3H3,(H,25,26,29)
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Daiichi Sankyo Company, Limited

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Assay Description
Inhibitory activity-1 assay: To a solution containing 20 mM Tris-HCl (pH 7.5), 1 mM MgCl2, 100 μM EDTA, 330 μg/ml bovine serum albumin, 50 ...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252899
PNG
(US9464076, 51)
Show SMILES CC(=O)c1ccc(C(C)=O)c2c(C)c(sc12)C(=O)Nc1cc(CN2CCC(O)C2)c2ccccc2n1
Show InChI InChI=1S/C28H27N3O4S/c1-15-25-20(16(2)32)8-9-21(17(3)33)27(25)36-26(15)28(35)30-24-12-18(13-31-11-10-19(34)14-31)22-6-4-5-7-23(22)29-24/h4-9,12,19,34H,10-11,13-14H2,1-3H3,(H,29,30,35)
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Daiichi Sankyo Company, Limited

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Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252918
PNG
(US9464076, 70)
Show SMILES CCOCc1cccc2nc(NC(=O)c3sc4c(ccc(COC)c4c3C)C(C)=O)ccc12
Show InChI InChI=1S/C26H26N2O4S/c1-5-32-14-17-7-6-8-21-20(17)11-12-22(27-21)28-26(30)24-15(2)23-18(13-31-4)9-10-19(16(3)29)25(23)33-24/h6-12H,5,13-14H2,1-4H3,(H,27,28,30)
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Daiichi Sankyo Company, Limited

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Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252849
PNG
(US9464076, 1)
Show SMILES CC(=O)c1ccc(C(C)=O)c2c(C)c(sc12)C(=O)Nc1ccc2ccccc2n1
Show InChI InChI=1S/C23H18N2O3S/c1-12-20-16(13(2)26)9-10-17(14(3)27)22(20)29-21(12)23(28)25-19-11-8-15-6-4-5-7-18(15)24-19/h4-11H,1-3H3,(H,24,25,28)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252905
PNG
(US9464076, 57)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(N4CCN(C)CC4)c4ccccc4n3)c(C)c12
Show InChI InChI=1S/C28H30N4O3S/c1-17-25-19(16-35-4)9-10-20(18(2)33)27(25)36-26(17)28(34)30-24-15-23(32-13-11-31(3)12-14-32)21-7-5-6-8-22(21)29-24/h5-10,15H,11-14,16H2,1-4H3,(H,29,30,34)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252874
PNG
(US9464076, 26 | US9464076, 27 | US9464076, 28)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(c4ccccc4n3)C(C)(C)O)c(C)c12
Show InChI InChI=1S/C26H26N2O4S/c1-14-22-16(13-32-5)10-11-17(15(2)29)24(22)33-23(14)25(30)28-21-12-19(26(3,4)31)18-8-6-7-9-20(18)27-21/h6-12,31H,13H2,1-5H3,(H,27,28,30)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
Inhibitory activity-1 assay: To a solution containing 20 mM Tris-HCl (pH 7.5), 1 mM MgCl2, 100 μM EDTA, 330 μg/ml bovine serum albumin, 50 ...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252956
PNG
(US9464076, 108)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(C)cccc4n3)c(C)c12
Show InChI InChI=1S/C24H22N2O3S/c1-13-6-5-7-19-17(13)10-11-20(25-19)26-24(28)22-14(2)21-16(12-29-4)8-9-18(15(3)27)23(21)30-22/h5-11H,12H2,1-4H3,(H,25,26,28)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252925
PNG
(US9464076, 119 | US9464076, 120 | US9464076, 77 | ...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(CO)cccc4n3)c(C)c12
Show InChI InChI=1S/C24H22N2O4S/c1-13-21-16(12-30-3)7-8-17(14(2)28)23(21)31-22(13)24(29)26-20-10-9-18-15(11-27)5-4-6-19(18)25-20/h4-10,27H,11-12H2,1-3H3,(H,25,26,29)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
Inhibitory activity-1 assay: To a solution containing 20 mM Tris-HCl (pH 7.5), 1 mM MgCl2, 100 μM EDTA, 330 μg/ml bovine serum albumin, 50 ...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252874
PNG
(US9464076, 26 | US9464076, 27 | US9464076, 28)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(c4ccccc4n3)C(C)(C)O)c(C)c12
Show InChI InChI=1S/C26H26N2O4S/c1-14-22-16(13-32-5)10-11-17(15(2)29)24(22)33-23(14)25(30)28-21-12-19(26(3,4)31)18-8-6-7-9-20(18)27-21/h6-12,31H,13H2,1-5H3,(H,27,28,30)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252910
PNG
(US9464076, 62)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(CN(C)C)cccc4n3)c(C)c12
Show InChI InChI=1S/C26H27N3O3S/c1-15-23-18(14-32-5)9-10-19(16(2)30)25(23)33-24(15)26(31)28-22-12-11-20-17(13-29(3)4)7-6-8-21(20)27-22/h6-12H,13-14H2,1-5H3,(H,27,28,31)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252915
PNG
(US9464076, 117 | US9464076, 118 | US9464076, 67 | ...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(COC)cccc4n3)c(C)c12
Show InChI InChI=1S/C25H24N2O4S/c1-14-22-17(13-31-4)8-9-18(15(2)28)24(22)32-23(14)25(29)27-21-11-10-19-16(12-30-3)6-5-7-20(19)26-21/h5-11H,12-13H2,1-4H3,(H,26,27,29)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
Inhibitory activity-1 assay: To a solution containing 20 mM Tris-HCl (pH 7.5), 1 mM MgCl2, 100 μM EDTA, 330 μg/ml bovine serum albumin, 50 ...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252925
PNG
(US9464076, 119 | US9464076, 120 | US9464076, 77 | ...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(CO)cccc4n3)c(C)c12
Show InChI InChI=1S/C24H22N2O4S/c1-13-21-16(12-30-3)7-8-17(14(2)28)23(21)31-22(13)24(29)26-20-10-9-18-15(11-27)5-4-6-19(18)25-20/h4-10,27H,11-12H2,1-3H3,(H,25,26,29)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
Inhibitory activity-1 assay: To a solution containing 20 mM Tris-HCl (pH 7.5), 1 mM MgCl2, 100 μM EDTA, 330 μg/ml bovine serum albumin, 50 ...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252915
PNG
(US9464076, 117 | US9464076, 118 | US9464076, 67 | ...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(COC)cccc4n3)c(C)c12
Show InChI InChI=1S/C25H24N2O4S/c1-14-22-17(13-31-4)8-9-18(15(2)28)24(22)32-23(14)25(29)27-21-11-10-19-16(12-30-3)6-5-7-20(19)26-21/h5-11H,12-13H2,1-4H3,(H,26,27,29)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
Inhibitory activity-1 assay: To a solution containing 20 mM Tris-HCl (pH 7.5), 1 mM MgCl2, 100 μM EDTA, 330 μg/ml bovine serum albumin, 50 ...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252921
PNG
(US9464076, 73)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(COC(F)F)cccc4n3)c(C)c12
Show InChI InChI=1S/C25H22F2N2O4S/c1-13-21-16(11-32-3)7-8-17(14(2)30)23(21)34-22(13)24(31)29-20-10-9-18-15(12-33-25(26)27)5-4-6-19(18)28-20/h4-10,25H,11-12H2,1-3H3,(H,28,29,31)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252874
PNG
(US9464076, 26 | US9464076, 27 | US9464076, 28)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(c4ccccc4n3)C(C)(C)O)c(C)c12
Show InChI InChI=1S/C26H26N2O4S/c1-14-22-16(13-32-5)10-11-17(15(2)29)24(22)33-23(14)25(30)28-21-12-19(26(3,4)31)18-8-6-7-9-20(18)27-21/h6-12,31H,13H2,1-5H3,(H,27,28,30)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
Inhibitory activity-1 assay: To a solution containing 20 mM Tris-HCl (pH 7.5), 1 mM MgCl2, 100 μM EDTA, 330 μg/ml bovine serum albumin, 50 ...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252861
PNG
(US9464076, 13)
Show SMILES CC(O)c1cc(NC(=O)c2sc3c(ccc(C(C)=O)c3c2C)C(C)=O)nc2ccccc12
Show InChI InChI=1S/C25H22N2O4S/c1-12-22-16(13(2)28)9-10-17(14(3)29)24(22)32-23(12)25(31)27-21-11-19(15(4)30)18-7-5-6-8-20(18)26-21/h5-11,15,30H,1-4H3,(H,26,27,31)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252950
PNG
(US9464076, 102 | US9464076, 103 | US9464076, 104 |...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(=O)N3CC(C3)OC)c(C)c12
Show InChI InChI=1S/C28H27N3O5S/c1-15-24-17(14-35-3)8-9-19(16(2)32)26(24)37-25(15)27(33)30-23-11-10-20-21(6-5-7-22(20)29-23)28(34)31-12-18(13-31)36-4/h5-11,18H,12-14H2,1-4H3,(H,29,30,33)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
Inhibitory activity-1 assay: To a solution containing 20 mM Tris-HCl (pH 7.5), 1 mM MgCl2, 100 μM EDTA, 330 μg/ml bovine serum albumin, 50 ...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252892
PNG
(US9464076, 44)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CCOCC4)c4ccccc4n3)c(C)c12
Show InChI InChI=1S/C28H29N3O4S/c1-17-25-19(16-34-3)8-9-21(18(2)32)27(25)36-26(17)28(33)30-24-14-20(15-31-10-12-35-13-11-31)22-6-4-5-7-23(22)29-24/h4-9,14H,10-13,15-16H2,1-3H3,(H,29,30,33)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252962
PNG
(US9464076, 114)
Show SMILES CC(=O)c1ccc(CO)c2c(C)c(sc12)C(=O)Nc1ccc2c(CO)cccc2n1
Show InChI InChI=1S/C23H20N2O4S/c1-12-20-15(11-27)6-7-16(13(2)28)22(20)30-21(12)23(29)25-19-9-8-17-14(10-26)4-3-5-18(17)24-19/h3-9,26-27H,10-11H2,1-2H3,(H,24,25,29)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252859
PNG
(US9464076, 11)
Show SMILES CC(=O)c1ccc(C(C)=O)c2c(C)c(sc12)C(=O)Nc1cc(C)c2ccccc2n1
Show InChI InChI=1S/C24H20N2O3S/c1-12-11-20(25-19-8-6-5-7-16(12)19)26-24(29)22-13(2)21-17(14(3)27)9-10-18(15(4)28)23(21)30-22/h5-11H,1-4H3,(H,25,26,29)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252950
PNG
(US9464076, 102 | US9464076, 103 | US9464076, 104 |...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(=O)N3CC(C3)OC)c(C)c12
Show InChI InChI=1S/C28H27N3O5S/c1-15-24-17(14-35-3)8-9-19(16(2)32)26(24)37-25(15)27(33)30-23-11-10-20-21(6-5-7-22(20)29-23)28(34)31-12-18(13-31)36-4/h5-11,18H,12-14H2,1-4H3,(H,29,30,33)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
Inhibitory activity-1 assay: To a solution containing 20 mM Tris-HCl (pH 7.5), 1 mM MgCl2, 100 μM EDTA, 330 μg/ml bovine serum albumin, 50 ...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252863
PNG
(US9464076, 15)
Show SMILES CN(Cc1cc(NC(=O)c2sc3c(ccc(C(C)=O)c3c2C)C(C)=O)nc2ccccc12)C(C)=O
Show InChI InChI=1S/C27H25N3O4S/c1-14-24-19(15(2)31)10-11-20(16(3)32)26(24)35-25(14)27(34)29-23-12-18(13-30(5)17(4)33)21-8-6-7-9-22(21)28-23/h6-12H,13H2,1-5H3,(H,28,29,34)
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Daiichi Sankyo Company, Limited

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Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252865
PNG
(US9464076, 17)
Show SMILES CCCC(=O)c1cccc2c(C)c(sc12)C(=O)Nc1cc(c2ccccc2n1)C(C)(C)O
Show InChI InChI=1S/C26H26N2O3S/c1-5-9-21(29)18-12-8-11-16-15(2)23(32-24(16)18)25(30)28-22-14-19(26(3,4)31)17-10-6-7-13-20(17)27-22/h6-8,10-14,31H,5,9H2,1-4H3,(H,27,28,30)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252850
PNG
(US9464076, 2 | US9464076, 3 | US9464076, 4 | US946...)
Show SMILES CC(=O)c1ccc(C(C)=O)c2c(C)c(sc12)C(=O)Nc1cc(c2ccccc2n1)C(C)(C)O
Show InChI InChI=1S/C26H24N2O4S/c1-13-22-16(14(2)29)10-11-17(15(3)30)24(22)33-23(13)25(31)28-21-12-19(26(4,5)32)18-8-6-7-9-20(18)27-21/h6-12,32H,1-5H3,(H,27,28,31)
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Daiichi Sankyo Company, Limited

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Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252898
PNG
(US9464076, 50)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(C(=O)N4CC[C@@H](O)C4)c4ccccc4n3)c(C)c12
Show InChI InChI=1S/C28H27N3O5S/c1-15-24-17(14-36-3)8-9-19(16(2)32)26(24)37-25(15)27(34)30-23-12-21(20-6-4-5-7-22(20)29-23)28(35)31-11-10-18(33)13-31/h4-9,12,18,33H,10-11,13-14H2,1-3H3,(H,29,30,34)/t18-/m1/s1
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252968
PNG
(US9464076, 124)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CCNCC4)c4ccccc4n3)c(C)c12
Show InChI InChI=1S/C28H30N4O3S/c1-17-25-19(16-35-3)8-9-21(18(2)33)27(25)36-26(17)28(34)31-24-14-20(15-32-12-10-29-11-13-32)22-6-4-5-7-23(22)30-24/h4-9,14,29H,10-13,15-16H2,1-3H3,(H,30,31,34)
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Daiichi Sankyo Company, Limited

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Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252922
PNG
(US9464076, 74)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(C)(C)O)c(C)c12
Show InChI InChI=1S/C26H26N2O4S/c1-14-22-16(13-32-5)9-10-17(15(2)29)24(22)33-23(14)25(30)28-21-12-11-18-19(26(3,4)31)7-6-8-20(18)27-21/h6-12,31H,13H2,1-5H3,(H,27,28,30)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252877
PNG
(US9464076, 29)
Show SMILES CCOCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(c4ccccc4n3)C(C)(C)O)c(C)c12
Show InChI InChI=1S/C27H28N2O4S/c1-6-33-14-17-11-12-18(16(3)30)25-23(17)15(2)24(34-25)26(31)29-22-13-20(27(4,5)32)19-9-7-8-10-21(19)28-22/h7-13,32H,6,14H2,1-5H3,(H,28,29,31)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252925
PNG
(US9464076, 119 | US9464076, 120 | US9464076, 77 | ...)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(CO)cccc4n3)c(C)c12
Show InChI InChI=1S/C24H22N2O4S/c1-13-21-16(12-30-3)7-8-17(14(2)28)23(21)31-22(13)24(29)26-20-10-9-18-15(11-27)5-4-6-19(18)25-20/h4-10,27H,11-12H2,1-3H3,(H,25,26,29)
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Daiichi Sankyo Company, Limited

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Assay Description
Inhibitory activity-1 assay: To a solution containing 20 mM Tris-HCl (pH 7.5), 1 mM MgCl2, 100 μM EDTA, 330 μg/ml bovine serum albumin, 50 ...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252873
PNG
(US9464076, 25)
Show SMILES Cc1c(sc2c(cccc12)C(=O)C1CCCC1)C(=O)Nc1cc(c2ccccc2n1)C(C)(C)O
Show InChI InChI=1S/C28H28N2O3S/c1-16-18-12-8-13-20(24(31)17-9-4-5-10-17)26(18)34-25(16)27(32)30-23-15-21(28(2,3)33)19-11-6-7-14-22(19)29-23/h6-8,11-15,17,33H,4-5,9-10H2,1-3H3,(H,29,30,32)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252860
PNG
(US9464076, 12)
Show SMILES COc1cc(NC(=O)c2sc3c(ccc(C(C)=O)c3c2C)C(C)=O)nc2ccccc12
Show InChI InChI=1S/C24H20N2O4S/c1-12-21-15(13(2)27)9-10-16(14(3)28)23(21)31-22(12)24(29)26-20-11-19(30-4)17-7-5-6-8-18(17)25-20/h5-11H,1-4H3,(H,25,26,29)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252864
PNG
(US9464076, 16)
Show SMILES CCC(=O)c1cccc2c(C)c(sc12)C(=O)Nc1cc(c2ccccc2n1)C(C)(C)O
Show InChI InChI=1S/C25H24N2O3S/c1-5-20(28)17-11-8-10-15-14(2)22(31-23(15)17)24(29)27-21-13-18(25(3,4)30)16-9-6-7-12-19(16)26-21/h6-13,30H,5H2,1-4H3,(H,26,27,29)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252855
PNG
(US9464076, 7)
Show SMILES CCc1c(sc2c(ccc(C(C)=O)c12)C(C)=O)C(=O)Nc1cc(c2ccccc2n1)C(C)(C)O
Show InChI InChI=1S/C27H26N2O4S/c1-6-16-23-17(14(2)30)11-12-18(15(3)31)24(23)34-25(16)26(32)29-22-13-20(27(4,5)33)19-9-7-8-10-21(19)28-22/h7-13,33H,6H2,1-5H3,(H,28,29,32)
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Daiichi Sankyo Company, Limited

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Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252850
PNG
(US9464076, 2 | US9464076, 3 | US9464076, 4 | US946...)
Show SMILES CC(=O)c1ccc(C(C)=O)c2c(C)c(sc12)C(=O)Nc1cc(c2ccccc2n1)C(C)(C)O
Show InChI InChI=1S/C26H24N2O4S/c1-13-22-16(14(2)29)10-11-17(15(3)30)24(22)33-23(13)25(31)28-21-12-19(26(4,5)32)18-8-6-7-9-20(18)27-21/h6-12,32H,1-5H3,(H,27,28,31)
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Daiichi Sankyo Company, Limited

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Assay Description
Inhibitory activity-1 assay: To a solution containing 20 mM Tris-HCl (pH 7.5), 1 mM MgCl2, 100 μM EDTA, 330 μg/ml bovine serum albumin, 50 ...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252850
PNG
(US9464076, 2 | US9464076, 3 | US9464076, 4 | US946...)
Show SMILES CC(=O)c1ccc(C(C)=O)c2c(C)c(sc12)C(=O)Nc1cc(c2ccccc2n1)C(C)(C)O
Show InChI InChI=1S/C26H24N2O4S/c1-13-22-16(14(2)29)10-11-17(15(3)30)24(22)33-23(13)25(31)28-21-12-19(26(4,5)32)18-8-6-7-9-20(18)27-21/h6-12,32H,1-5H3,(H,27,28,31)
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Daiichi Sankyo Company, Limited

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Assay Description
Inhibitory activity-1 assay: To a solution containing 20 mM Tris-HCl (pH 7.5), 1 mM MgCl2, 100 μM EDTA, 330 μg/ml bovine serum albumin, 50 ...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252850
PNG
(US9464076, 2 | US9464076, 3 | US9464076, 4 | US946...)
Show SMILES CC(=O)c1ccc(C(C)=O)c2c(C)c(sc12)C(=O)Nc1cc(c2ccccc2n1)C(C)(C)O
Show InChI InChI=1S/C26H24N2O4S/c1-13-22-16(14(2)29)10-11-17(15(3)30)24(22)33-23(13)25(31)28-21-12-19(26(4,5)32)18-8-6-7-9-20(18)27-21/h6-12,32H,1-5H3,(H,27,28,31)
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Daiichi Sankyo Company, Limited

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Assay Description
Inhibitory activity-1 assay: To a solution containing 20 mM Tris-HCl (pH 7.5), 1 mM MgCl2, 100 μM EDTA, 330 μg/ml bovine serum albumin, 50 ...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252891
PNG
(US9464076, 43)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CCCC4)c4ccccc4n3)c(C)c12
Show InChI InChI=1S/C28H29N3O3S/c1-17-25-19(16-34-3)10-11-21(18(2)32)27(25)35-26(17)28(33)30-24-14-20(15-31-12-6-7-13-31)22-8-4-5-9-23(22)29-24/h4-5,8-11,14H,6-7,12-13,15-16H2,1-3H3,(H,29,30,33)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252932
PNG
(US9464076, 84)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(COC(=O)[C@@H](N)C(C)C)cccc4n3)c(C)c12
Show InChI InChI=1S/C29H31N3O5S/c1-15(2)25(30)29(35)37-14-18-7-6-8-22-21(18)11-12-23(31-22)32-28(34)26-16(3)24-19(13-36-5)9-10-20(17(4)33)27(24)38-26/h6-12,15,25H,13-14,30H2,1-5H3,(H,31,32,34)/t25-/m0/s1
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Daiichi Sankyo Company, Limited

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Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252857
PNG
(US9464076, 9)
Show SMILES CC(O)c1ccc(C(C)=O)c2sc(C(=O)Nc3cc(c4ccccc4n3)C(C)(C)O)c(C)c12
Show InChI InChI=1S/C26H26N2O4S/c1-13-22-16(14(2)29)10-11-17(15(3)30)24(22)33-23(13)25(31)28-21-12-19(26(4,5)32)18-8-6-7-9-20(18)27-21/h6-12,14,29,32H,1-5H3,(H,27,28,31)
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Daiichi Sankyo Company, Limited

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Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252880
PNG
(US9464076, 32)
Show SMILES COC(C)c1ccc(C(C)=O)c2sc(C(=O)Nc3cc(c4ccccc4n3)C(C)(C)O)c(C)c12
Show InChI InChI=1S/C27H28N2O4S/c1-14-23-18(16(3)33-6)12-11-17(15(2)30)25(23)34-24(14)26(31)29-22-13-20(27(4,5)32)19-9-7-8-10-21(19)28-22/h7-13,16,32H,1-6H3,(H,28,29,31)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252871
PNG
(US9464076, 23)
Show SMILES CC(C)CC(=O)c1cccc2c(C)c(sc12)C(=O)Nc1cc(c2ccccc2n1)C(C)(C)O
Show InChI InChI=1S/C27H28N2O3S/c1-15(2)13-22(30)19-11-8-10-17-16(3)24(33-25(17)19)26(31)29-23-14-20(27(4,5)32)18-9-6-7-12-21(18)28-23/h6-12,14-15,32H,13H2,1-5H3,(H,28,29,31)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252868
PNG
(US9464076, 20)
Show SMILES CCCCC(=O)c1cccc2c(C)c(sc12)C(=O)Nc1cc(c2ccccc2n1)C(C)(C)O
Show InChI InChI=1S/C27H28N2O3S/c1-5-6-14-22(30)19-12-9-11-17-16(2)24(33-25(17)19)26(31)29-23-15-20(27(3,4)32)18-10-7-8-13-21(18)28-23/h7-13,15,32H,5-6,14H2,1-4H3,(H,28,29,31)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252850
PNG
(US9464076, 2 | US9464076, 3 | US9464076, 4 | US946...)
Show SMILES CC(=O)c1ccc(C(C)=O)c2c(C)c(sc12)C(=O)Nc1cc(c2ccccc2n1)C(C)(C)O
Show InChI InChI=1S/C26H24N2O4S/c1-13-22-16(14(2)29)10-11-17(15(3)30)24(22)33-23(13)25(31)28-21-12-19(26(4,5)32)18-8-6-7-9-20(18)27-21/h6-12,32H,1-5H3,(H,27,28,31)
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Daiichi Sankyo Company, Limited

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Assay Description
Inhibitory activity-1 assay: To a solution containing 20 mM Tris-HCl (pH 7.5), 1 mM MgCl2, 100 μM EDTA, 330 μg/ml bovine serum albumin, 50 ...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252878
PNG
(US9464076, 30)
Show SMILES CCCOCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(c4ccccc4n3)C(C)(C)O)c(C)c12
Show InChI InChI=1S/C28H30N2O4S/c1-6-13-34-15-18-11-12-19(17(3)31)26-24(18)16(2)25(35-26)27(32)30-23-14-21(28(4,5)33)20-9-7-8-10-22(20)29-23/h7-12,14,33H,6,13,15H2,1-5H3,(H,29,30,32)
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Daiichi Sankyo Company, Limited

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Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252940
PNG
(US9464076, 92)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(=O)OC)c(C)c12
Show InChI InChI=1S/C25H22N2O5S/c1-13-21-15(12-31-3)8-9-16(14(2)28)23(21)33-22(13)24(29)27-20-11-10-17-18(25(30)32-4)6-5-7-19(17)26-20/h5-11H,12H2,1-4H3,(H,26,27,29)
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Daiichi Sankyo Company, Limited

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Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252856
PNG
(US9464076, 8)
Show SMILES CC(=O)c1ccc(C(C)=O)c2sc(cc12)C(=O)Nc1cc(c2ccccc2n1)C(C)(C)O
Show InChI InChI=1S/C25H22N2O4S/c1-13(28)15-9-10-16(14(2)29)23-18(15)11-21(32-23)24(30)27-22-12-19(25(3,4)31)17-7-5-6-8-20(17)26-22/h5-12,31H,1-4H3,(H,26,27,30)
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Daiichi Sankyo Company, Limited

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Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252879
PNG
(US9464076, 31)
Show SMILES CC(C)OCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(c4ccccc4n3)C(C)(C)O)c(C)c12
Show InChI InChI=1S/C28H30N2O4S/c1-15(2)34-14-18-11-12-19(17(4)31)26-24(18)16(3)25(35-26)27(32)30-23-13-21(28(5,6)33)20-9-7-8-10-22(20)29-23/h7-13,15,33H,14H2,1-6H3,(H,29,30,32)
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Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252901
PNG
(US9464076, 53)
Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(Cl)c4ccccc4n3)c(C)c12
Show InChI InChI=1S/C23H19ClN2O3S/c1-12-20-14(11-29-3)8-9-15(13(2)27)22(20)30-21(12)23(28)26-19-10-17(24)16-6-4-5-7-18(16)25-19/h4-10H,11H2,1-3H3,(H,25,26,28)
PDB

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UniChem
US Patent
n/an/a 18n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252858
PNG
(US9464076, 10)
Show SMILES CCC(=O)c1ccc(C(C)=O)c2sc(C(=O)Nc3cc(c4ccccc4n3)C(C)(C)O)c(C)c12
Show InChI InChI=1S/C27H26N2O4S/c1-6-21(31)18-12-11-16(15(3)30)25-23(18)14(2)24(34-25)26(32)29-22-13-19(27(4,5)33)17-9-7-8-10-20(17)28-22/h7-13,33H,6H2,1-5H3,(H,28,29,32)
PDB

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n/an/a 20n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM252872
PNG
(US9464076, 24)
Show SMILES CCC(CC)C(=O)c1cccc2c(C)c(sc12)C(=O)Nc1cc(c2ccccc2n1)C(C)(C)O
Show InChI InChI=1S/C28H30N2O3S/c1-6-17(7-2)24(31)20-13-10-12-18-16(3)25(34-26(18)20)27(32)30-23-15-21(28(4,5)33)19-11-8-9-14-22(19)29-23/h8-15,17,33H,6-7H2,1-5H3,(H,29,30,32)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 25n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited

US Patent


Assay Description
A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%