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Patent code US9475775

Compile Data Set for Download or QSAR
Found 160 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254749
PNG
(US9475775, 16)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(c1)C(=O)N1CCCC1
Show InChI InChI=1S/C28H34N6O3/c1-3-9-33(10-4-2)27(36)21-13-19-7-8-20(15-24(19)32-25(29)16-21)26(35)31-23-14-22(17-30-18-23)28(37)34-11-5-6-12-34/h7-8,13-15,17-18H,3-6,9-12,16H2,1-2H3,(H2,29,32)(H,31,35)
UniProtKB/SwissProt

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UniChem
US Patent
n/an/an/an/a>1.00E+5n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254750
PNG
(US9475775, 17 | US9475775, 54)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(CCN)c1
Show InChI InChI=1S/C26H33N5O2/c1-3-12-31(13-4-2)26(33)21-15-19-8-9-20(16-23(19)30-24(28)17-21)25(32)29-22-7-5-6-18(14-22)10-11-27/h5-9,14-16H,3-4,10-13,17,27H2,1-2H3,(H2,28,30)(H,29,32)
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US Patent
n/an/an/an/a>1.00E+5n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254752
PNG
(US9475775, 19)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(F)c1
Show InChI InChI=1S/C24H27FN4O2/c1-3-10-29(11-4-2)24(31)18-12-16-8-9-17(13-21(16)28-22(26)14-18)23(30)27-20-7-5-6-19(25)15-20/h5-9,12-13,15H,3-4,10-11,14H2,1-2H3,(H2,26,28)(H,27,30)
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US Patent
n/an/an/an/a>1.00E+5n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254757
PNG
(US9475775, 24)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1ccc(CN)cc1
Show InChI InChI=1S/C25H31N5O2/c1-3-11-30(12-4-2)25(32)20-13-18-7-8-19(14-22(18)29-23(27)15-20)24(31)28-21-9-5-17(16-26)6-10-21/h5-10,13-14H,3-4,11-12,15-16,26H2,1-2H3,(H2,27,29)(H,28,31)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254759
PNG
(US9475775, 26)
Show SMILES CCCN(CCCO)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C25H30N4O3/c1-3-10-29(11-5-12-30)25(32)20-14-18-8-9-19(15-22(18)28-23(26)16-20)24(31)27-21-7-4-6-17(2)13-21/h4,6-9,13-15,30H,3,5,10-12,16H2,1-2H3,(H2,26,28)(H,27,31)
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US Patent
n/an/an/an/a>1.00E+5n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254767
PNG
(US9475775, 34)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1ccnnc1
Show InChI InChI=1S/C22H26N6O2/c1-3-9-28(10-4-2)22(30)17-11-15-5-6-16(12-19(15)27-20(23)13-17)21(29)26-18-7-8-24-25-14-18/h5-8,11-12,14H,3-4,9-10,13H2,1-2H3,(H2,23,27)(H,24,26,29)
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n/an/an/an/a>1.00E+5n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254773
PNG
(US9475775, 40)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(OC)c1
Show InChI InChI=1S/C24H29N5O3/c1-4-8-29(9-5-2)24(31)18-10-16-6-7-17(11-21(16)28-22(25)12-18)23(30)27-19-13-20(32-3)15-26-14-19/h6-7,10-11,13-15H,4-5,8-9,12H2,1-3H3,(H2,25,28)(H,27,30)
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n/an/an/an/a>1.00E+5n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254750
PNG
(US9475775, 17 | US9475775, 54)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(CCN)c1
Show InChI InChI=1S/C26H33N5O2/c1-3-12-31(13-4-2)26(33)21-15-19-8-9-20(16-23(19)30-24(28)17-21)25(32)29-22-7-5-6-18(14-22)10-11-27/h5-9,14-16H,3-4,10-13,17,27H2,1-2H3,(H2,28,30)(H,29,32)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254788
PNG
(US9475775, 55)
Show SMILES CCCN(CC(C)C)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C26H32N4O2/c1-5-11-30(16-17(2)3)26(32)21-13-19-9-10-20(14-23(19)29-24(27)15-21)25(31)28-22-8-6-7-18(4)12-22/h6-10,12-14,17H,5,11,15-16H2,1-4H3,(H2,27,29)(H,28,31)
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US Patent
n/an/an/an/a>1.00E+5n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254793
PNG
(US9475775, 60)
Show SMILES CCCN(Cc1ccc(CN)cc1)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C30H33N5O2/c1-3-13-35(19-22-9-7-21(18-31)8-10-22)30(37)25-15-23-11-12-24(16-27(23)34-28(32)17-25)29(36)33-26-6-4-5-20(2)14-26/h4-12,14-16H,3,13,17-19,31H2,1-2H3,(H2,32,34)(H,33,36)
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US Patent
n/an/an/an/a>1.00E+5n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254803
PNG
(US9475775, 70)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(CCc2ccc(OC)cc2)c1
Show InChI InChI=1S/C32H37N5O3/c1-4-14-37(15-5-2)32(39)26-17-24-10-11-25(18-29(24)36-30(33)19-26)31(38)35-27-16-23(20-34-21-27)7-6-22-8-12-28(40-3)13-9-22/h8-13,16-18,20-21H,4-7,14-15,19H2,1-3H3,(H2,33,36)(H,35,38)
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US Patent
n/an/an/an/a>1.00E+5n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254735
PNG
(US9475775, 2)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncnc1
Show InChI InChI=1S/C22H26N6O2/c1-3-7-28(8-4-2)22(30)17-9-15-5-6-16(10-19(15)27-20(23)11-17)21(29)26-18-12-24-14-25-13-18/h5-6,9-10,12-14H,3-4,7-8,11H2,1-2H3,(H2,23,27)(H,26,29)
PDB

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US Patent
n/an/an/an/a 1n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254739
PNG
(US9475775, 6)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(CO)c1
Show InChI InChI=1S/C24H29N5O3/c1-3-7-29(8-4-2)24(32)19-10-17-5-6-18(11-21(17)28-22(25)12-19)23(31)27-20-9-16(15-30)13-26-14-20/h5-6,9-11,13-14,30H,3-4,7-8,12,15H2,1-2H3,(H2,25,28)(H,27,31)
PDB

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US Patent
n/an/an/an/a 8n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254745
PNG
(US9475775, 12)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncn1C
Show InChI InChI=1S/C22H28N6O2/c1-4-8-28(9-5-2)22(30)17-10-15-6-7-16(11-18(15)25-19(23)12-17)21(29)26-20-13-24-14-27(20)3/h6-7,10-11,13-14H,4-5,8-9,12H2,1-3H3,(H2,23,25)(H,26,29)
PDB

UniProtKB/SwissProt

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US Patent
n/an/an/an/a 4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254746
PNG
(US9475775, 13)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C24H27FN4O2/c1-3-11-29(12-4-2)24(31)18-13-16-5-6-17(14-21(16)28-22(26)15-18)23(30)27-20-9-7-19(25)8-10-20/h5-10,13-14H,3-4,11-12,15H2,1-2H3,(H2,26,28)(H,27,30)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 7n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254751
PNG
(US9475775, 18)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(C)c1
Show InChI InChI=1S/C24H29N5O2/c1-4-8-29(9-5-2)24(31)19-11-17-6-7-18(12-21(17)28-22(25)13-19)23(30)27-20-10-16(3)14-26-15-20/h6-7,10-12,14-15H,4-5,8-9,13H2,1-3H3,(H2,25,28)(H,27,30)
PDB

UniProtKB/SwissProt

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PC cid
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UniChem
US Patent
n/an/an/an/a 2n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254756
PNG
(US9475775, 23)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cc(C)cc(C)c1
Show InChI InChI=1S/C26H32N4O2/c1-5-9-30(10-6-2)26(32)21-14-19-7-8-20(15-23(19)29-24(27)16-21)25(31)28-22-12-17(3)11-18(4)13-22/h7-8,11-15H,5-6,9-10,16H2,1-4H3,(H2,27,29)(H,28,31)
PDB

UniProtKB/SwissProt

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US Patent
n/an/an/an/a 1n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254772
PNG
(US9475775, 39)
Show SMILES CCCN(CCCO)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccnc1
Show InChI InChI=1S/C23H27N5O3/c1-2-9-28(10-4-11-29)23(31)18-12-16-6-7-17(13-20(16)27-21(24)14-18)22(30)26-19-5-3-8-25-15-19/h3,5-8,12-13,15,29H,2,4,9-11,14H2,1H3,(H2,24,27)(H,26,30)
PDB

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n/an/an/an/a 29n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254793
PNG
(US9475775, 60)
Show SMILES CCCN(Cc1ccc(CN)cc1)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C30H33N5O2/c1-3-13-35(19-22-9-7-21(18-31)8-10-22)30(37)25-15-23-11-12-24(16-27(23)34-28(32)17-25)29(36)33-26-6-4-5-20(2)14-26/h4-12,14-16H,3,13,17-19,31H2,1-2H3,(H2,32,34)(H,33,36)
PDB

UniProtKB/SwissProt

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US Patent
n/an/an/an/a 27n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254794
PNG
(US9475775, 61)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1ccc(CCCN)cc1
Show InChI InChI=1S/C27H35N5O2/c1-3-14-32(15-4-2)27(34)22-16-20-9-10-21(17-24(20)31-25(29)18-22)26(33)30-23-11-7-19(8-12-23)6-5-13-28/h7-12,16-17H,3-6,13-15,18,28H2,1-2H3,(H2,29,31)(H,30,33)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 5n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254803
PNG
(US9475775, 70)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(CCc2ccc(OC)cc2)c1
Show InChI InChI=1S/C32H37N5O3/c1-4-14-37(15-5-2)32(39)26-17-24-10-11-25(18-29(24)36-30(33)19-26)31(38)35-27-16-23(20-34-21-27)7-6-22-8-12-28(40-3)13-9-22/h8-13,16-18,20-21H,4-7,14-15,19H2,1-3H3,(H2,33,36)(H,35,38)
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 12n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


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More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254806
PNG
(US9475775, 73)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(CCc2cccc(OC)c2)c1
Show InChI InChI=1S/C32H37N5O3/c1-4-13-37(14-5-2)32(39)26-17-24-11-12-25(18-29(24)36-30(33)19-26)31(38)35-27-15-23(20-34-21-27)10-9-22-7-6-8-28(16-22)40-3/h6-8,11-12,15-18,20-21H,4-5,9-10,13-14,19H2,1-3H3,(H2,33,36)(H,35,38)
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n/an/an/an/a 10n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254809
PNG
(US9475775, 76)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(CCCCN)c1
Show InChI InChI=1S/C27H36N6O2/c1-3-11-33(12-4-2)27(35)22-14-20-8-9-21(15-24(20)32-25(29)16-22)26(34)31-23-13-19(17-30-18-23)7-5-6-10-28/h8-9,13-15,17-18H,3-7,10-12,16,28H2,1-2H3,(H2,29,32)(H,31,34)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254737
PNG
(US9475775, 4)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C24H28N4O2/c1-3-12-28(13-4-2)24(30)19-14-17-10-11-18(15-21(17)27-22(25)16-19)23(29)26-20-8-6-5-7-9-20/h5-11,14-15H,3-4,12-13,16H2,1-2H3,(H2,25,27)(H,26,29)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254746
PNG
(US9475775, 13)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C24H27FN4O2/c1-3-11-29(12-4-2)24(31)18-13-16-5-6-17(14-21(16)28-22(26)15-18)23(30)27-20-9-7-19(25)8-10-20/h5-10,13-14H,3-4,11-12,15H2,1-2H3,(H2,26,28)(H,27,30)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254747
PNG
(US9475775, 14)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C25H30N4O2/c1-4-11-29(12-5-2)25(31)20-14-18-9-10-19(15-22(18)28-23(26)16-20)24(30)27-21-8-6-7-17(3)13-21/h6-10,13-15H,4-5,11-12,16H2,1-3H3,(H2,26,28)(H,27,30)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254753
PNG
(US9475775, 20)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(F)c1
Show InChI InChI=1S/C23H26FN5O2/c1-3-7-29(8-4-2)23(31)17-9-15-5-6-16(10-20(15)28-21(25)11-17)22(30)27-19-12-18(24)13-26-14-19/h5-6,9-10,12-14H,3-4,7-8,11H2,1-2H3,(H2,25,28)(H,27,30)
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n/an/an/an/a 4.60E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254756
PNG
(US9475775, 23)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cc(C)cc(C)c1
Show InChI InChI=1S/C26H32N4O2/c1-5-9-30(10-6-2)26(32)21-14-19-7-8-20(15-23(19)29-24(27)16-21)25(31)28-22-12-17(3)11-18(4)13-22/h7-8,11-15H,5-6,9-10,16H2,1-4H3,(H2,27,29)(H,28,31)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254770
PNG
(US9475775, 37)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1ccn(C)n1
Show InChI InChI=1S/C22H28N6O2/c1-4-9-28(10-5-2)22(30)17-12-15-6-7-16(13-18(15)24-19(23)14-17)21(29)25-20-8-11-27(3)26-20/h6-8,11-13H,4-5,9-10,14H2,1-3H3,(H2,23,24)(H,25,26,29)
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n/an/an/an/a 3.80E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254776
PNG
(US9475775, 43)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cc(C)cc(CN)c1
Show InChI InChI=1S/C26H33N5O2/c1-4-8-31(9-5-2)26(33)21-13-19-6-7-20(14-23(19)30-24(28)15-21)25(32)29-22-11-17(3)10-18(12-22)16-27/h6-7,10-14H,4-5,8-9,15-16,27H2,1-3H3,(H2,28,30)(H,29,32)
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n/an/an/an/a 6.10E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254779
PNG
(US9475775, 46)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(OCCCCCN)c1
Show InChI InChI=1S/C28H38N6O3/c1-3-11-34(12-4-2)28(36)22-14-20-8-9-21(15-25(20)33-26(30)16-22)27(35)32-23-17-24(19-31-18-23)37-13-7-5-6-10-29/h8-9,14-15,17-19H,3-7,10-13,16,29H2,1-2H3,(H2,30,33)(H,32,35)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254792
PNG
(US9475775, 59)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(CCCN)c1
Show InChI InChI=1S/C27H35N5O2/c1-3-13-32(14-4-2)27(34)22-16-20-10-11-21(17-24(20)31-25(29)18-22)26(33)30-23-9-5-7-19(15-23)8-6-12-28/h5,7,9-11,15-17H,3-4,6,8,12-14,18,28H2,1-2H3,(H2,29,31)(H,30,33)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254802
PNG
(US9475775, 69)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(CCc2ccccc2)c1
Show InChI InChI=1S/C31H35N5O2/c1-3-14-36(15-4-2)31(38)26-17-24-12-13-25(18-28(24)35-29(32)19-26)30(37)34-27-16-23(20-33-21-27)11-10-22-8-6-5-7-9-22/h5-9,12-13,16-18,20-21H,3-4,10-11,14-15,19H2,1-2H3,(H2,32,35)(H,34,37)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254811
PNG
(US9475775, 78)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(CN(C)C)c1
Show InChI InChI=1S/C26H34N6O2/c1-5-9-32(10-6-2)26(34)21-12-19-7-8-20(13-23(19)30-24(27)14-21)25(33)29-22-11-18(15-28-16-22)17-31(3)4/h7-8,11-13,15-16H,5-6,9-10,14,17H2,1-4H3,(H2,27,30)(H,29,33)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254748
PNG
(US9475775, 15)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(c1)C(=O)N1CCCC1
Show InChI InChI=1S/C29H35N5O3/c1-3-12-33(13-4-2)29(37)23-16-20-10-11-21(18-25(20)32-26(30)19-23)27(35)31-24-9-7-8-22(17-24)28(36)34-14-5-6-15-34/h7-11,16-18H,3-6,12-15,19H2,1-2H3,(H2,30,32)(H,31,35)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254749
PNG
(US9475775, 16)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(c1)C(=O)N1CCCC1
Show InChI InChI=1S/C28H34N6O3/c1-3-9-33(10-4-2)27(36)21-13-19-7-8-20(15-24(19)32-25(29)16-21)26(35)31-23-14-22(17-30-18-23)28(37)34-11-5-6-12-34/h7-8,13-15,17-18H,3-6,9-12,16H2,1-2H3,(H2,29,32)(H,31,35)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254763
PNG
(US9475775, 30)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(OC)c1
Show InChI InChI=1S/C25H30N4O3/c1-4-11-29(12-5-2)25(31)19-13-17-9-10-18(14-22(17)28-23(26)15-19)24(30)27-20-7-6-8-21(16-20)32-3/h6-10,13-14,16H,4-5,11-12,15H2,1-3H3,(H2,26,28)(H,27,30)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254766
PNG
(US9475775, 33)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(CN)c1
Show InChI InChI=1S/C24H30N6O2/c1-3-7-30(8-4-2)24(32)19-10-17-5-6-18(11-21(17)29-22(26)12-19)23(31)28-20-9-16(13-25)14-27-15-20/h5-6,9-11,14-15H,3-4,7-8,12-13,25H2,1-2H3,(H2,26,29)(H,28,31)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254767
PNG
(US9475775, 34)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1ccnnc1
Show InChI InChI=1S/C22H26N6O2/c1-3-9-28(10-4-2)22(30)17-11-15-5-6-16(12-19(15)27-20(23)13-17)21(29)26-18-7-8-24-25-14-18/h5-8,11-12,14H,3-4,9-10,13H2,1-2H3,(H2,23,27)(H,24,26,29)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254777
PNG
(US9475775, 44 | US9475775, 79)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(OCC)c1
Show InChI InChI=1S/C25H31N5O3/c1-4-9-30(10-5-2)25(32)19-11-17-7-8-18(12-22(17)29-23(26)13-19)24(31)28-20-14-21(33-6-3)16-27-15-20/h7-8,11-12,14-16H,4-6,9-10,13H2,1-3H3,(H2,26,29)(H,28,31)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254778
PNG
(US9475775, 45)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(OCCOCCN)c1
Show InChI InChI=1S/C28H37N5O4/c1-3-11-33(12-4-2)28(35)22-16-20-8-9-21(17-25(20)32-26(30)18-22)27(34)31-23-6-5-7-24(19-23)37-15-14-36-13-10-29/h5-9,16-17,19H,3-4,10-15,18,29H2,1-2H3,(H2,30,32)(H,31,34)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254788
PNG
(US9475775, 55)
Show SMILES CCCN(CC(C)C)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C26H32N4O2/c1-5-11-30(16-17(2)3)26(32)21-13-19-9-10-20(14-23(19)29-24(27)15-21)25(31)28-22-8-6-7-18(4)12-22/h6-10,12-14,17H,5,11,15-16H2,1-4H3,(H2,27,29)(H,28,31)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254798
PNG
(US9475775, 65)
Show SMILES CCCCN(CCO)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C25H30N4O3/c1-3-4-10-29(11-12-30)25(32)20-14-18-8-9-19(15-22(18)28-23(26)16-20)24(31)27-21-7-5-6-17(2)13-21/h5-9,13-15,30H,3-4,10-12,16H2,1-2H3,(H2,26,28)(H,27,31)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


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More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254802
PNG
(US9475775, 69)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(CCc2ccccc2)c1
Show InChI InChI=1S/C31H35N5O2/c1-3-14-36(15-4-2)31(38)26-17-24-12-13-25(18-28(24)35-29(32)19-26)30(37)34-27-16-23(20-33-21-27)11-10-22-8-6-5-7-9-22/h5-9,12-13,16-18,20-21H,3-4,10-11,14-15,19H2,1-2H3,(H2,32,35)(H,34,37)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


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More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254805
PNG
(US9475775, 72)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(CCCCCN)c1
Show InChI InChI=1S/C28H38N6O2/c1-3-12-34(13-4-2)28(36)23-15-21-9-10-22(16-25(21)33-26(30)17-23)27(35)32-24-14-20(18-31-19-24)8-6-5-7-11-29/h9-10,14-16,18-19H,3-8,11-13,17,29H2,1-2H3,(H2,30,33)(H,32,35)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


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More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254811
PNG
(US9475775, 78)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(CN(C)C)c1
Show InChI InChI=1S/C26H34N6O2/c1-5-9-32(10-6-2)26(34)21-12-19-7-8-20(13-23(19)30-24(27)14-21)25(33)29-22-11-18(15-28-16-22)17-31(3)4/h7-8,11-13,15-16H,5-6,9-10,14,17H2,1-4H3,(H2,27,30)(H,29,33)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


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More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254745
PNG
(US9475775, 12)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncn1C
Show InChI InChI=1S/C22H28N6O2/c1-4-8-28(9-5-2)22(30)17-10-15-6-7-16(11-18(15)25-19(23)12-17)21(29)26-20-13-24-14-27(20)3/h6-7,10-11,13-14H,4-5,8-9,12H2,1-3H3,(H2,23,25)(H,26,29)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


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More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254760
PNG
(US9475775, 27)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1ccccc1C
Show InChI InChI=1S/C25H30N4O2/c1-4-12-29(13-5-2)25(31)20-14-18-10-11-19(15-22(18)27-23(26)16-20)24(30)28-21-9-7-6-8-17(21)3/h6-11,14-15H,4-5,12-13,16H2,1-3H3,(H2,26,27)(H,28,30)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


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More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254774
PNG
(US9475775, 41)
Show SMILES CCCN(CC#C)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C25H26N4O2/c1-4-11-29(12-5-2)25(31)20-14-18-9-10-19(15-22(18)28-23(26)16-20)24(30)27-21-8-6-7-17(3)13-21/h1,6-10,13-15H,5,11-12,16H2,2-3H3,(H2,26,28)(H,27,30)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


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More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254782
PNG
(US9475775, 49)
Show SMILES CCCN(CCCOCCOCCN)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C29H39N5O4/c1-3-11-34(12-5-13-37-15-16-38-14-10-30)29(36)24-18-22-8-9-23(19-26(22)33-27(31)20-24)28(35)32-25-7-4-6-21(2)17-25/h4,6-9,17-19H,3,5,10-16,20,30H2,1-2H3,(H2,31,33)(H,32,35)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254786
PNG
(US9475775, 53)
Show SMILES CCCN(CC1CC1)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C26H30N4O2/c1-3-11-30(16-18-7-8-18)26(32)21-13-19-9-10-20(14-23(19)29-24(27)15-21)25(31)28-22-6-4-5-17(2)12-22/h4-6,9-10,12-14,18H,3,7-8,11,15-16H2,1-2H3,(H2,27,29)(H,28,31)
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n/an/an/an/a 2.00E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254790
PNG
(US9475775, 57)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(CCCCCN)c1
Show InChI InChI=1S/C29H39N5O2/c1-3-15-34(16-4-2)29(36)24-18-22-12-13-23(19-26(22)33-27(31)20-24)28(35)32-25-11-8-10-21(17-25)9-6-5-7-14-30/h8,10-13,17-19H,3-7,9,14-16,20,30H2,1-2H3,(H2,31,33)(H,32,35)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254799
PNG
(US9475775, 66)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(OCCN)c1
Show InChI InChI=1S/C25H32N6O3/c1-3-8-31(9-4-2)25(33)19-11-17-5-6-18(12-22(17)30-23(27)13-19)24(32)29-20-14-21(16-28-15-20)34-10-7-26/h5-6,11-12,14-16H,3-4,7-10,13,26H2,1-2H3,(H2,27,30)(H,29,32)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254801
PNG
(US9475775, 68)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(\C=C\CN)c1
Show InChI InChI=1S/C26H32N6O2/c1-3-10-32(11-4-2)26(34)21-13-19-7-8-20(14-23(19)31-24(28)15-21)25(33)30-22-12-18(6-5-9-27)16-29-17-22/h5-8,12-14,16-17H,3-4,9-11,15,27H2,1-2H3,(H2,28,31)(H,30,33)/b6-5+
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254737
PNG
(US9475775, 4)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C24H28N4O2/c1-3-12-28(13-4-2)24(30)19-14-17-10-11-18(15-21(17)27-22(25)16-19)23(29)26-20-8-6-5-7-9-20/h5-11,14-15H,3-4,12-13,16H2,1-2H3,(H2,25,27)(H,26,29)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254741
PNG
(US9475775, 8)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(c1)S(C)(=O)=O
Show InChI InChI=1S/C25H30N4O4S/c1-4-11-29(12-5-2)25(31)19-13-17-9-10-18(14-22(17)28-23(26)15-19)24(30)27-20-7-6-8-21(16-20)34(3,32)33/h6-10,13-14,16H,4-5,11-12,15H2,1-3H3,(H2,26,28)(H,27,30)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254750
PNG
(US9475775, 17 | US9475775, 54)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(CCN)c1
Show InChI InChI=1S/C26H33N5O2/c1-3-12-31(13-4-2)26(33)21-15-19-8-9-20(16-23(19)30-24(28)17-21)25(32)29-22-7-5-6-18(14-22)10-11-27/h5-9,14-16H,3-4,10-13,17,27H2,1-2H3,(H2,28,30)(H,29,32)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254759
PNG
(US9475775, 26)
Show SMILES CCCN(CCCO)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C25H30N4O3/c1-3-10-29(11-5-12-30)25(32)20-14-18-8-9-19(15-22(18)28-23(26)16-20)24(31)27-21-7-4-6-17(2)13-21/h4,6-9,13-15,30H,3,5,10-12,16H2,1-2H3,(H2,26,28)(H,27,31)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254762
PNG
(US9475775, 29)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(CC)c1
Show InChI InChI=1S/C26H32N4O2/c1-4-12-30(13-5-2)26(32)21-15-19-10-11-20(16-23(19)29-24(27)17-21)25(31)28-22-9-7-8-18(6-3)14-22/h7-11,14-16H,4-6,12-13,17H2,1-3H3,(H2,27,29)(H,28,31)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254770
PNG
(US9475775, 37)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1ccn(C)n1
Show InChI InChI=1S/C22H28N6O2/c1-4-9-28(10-5-2)22(30)17-12-15-6-7-16(13-18(15)24-19(23)14-17)21(29)25-20-8-11-27(3)26-20/h6-8,11-13H,4-5,9-10,14H2,1-3H3,(H2,23,24)(H,25,26,29)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254780
PNG
(US9475775, 47)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(COCCOCCN)c1
Show InChI InChI=1S/C29H39N5O4/c1-3-11-34(12-4-2)29(36)24-17-22-8-9-23(18-26(22)33-27(31)19-24)28(35)32-25-7-5-6-21(16-25)20-38-15-14-37-13-10-30/h5-9,16-18H,3-4,10-15,19-20,30H2,1-2H3,(H2,31,33)(H,32,35)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254789
PNG
(US9475775, 56)
Show SMILES CCCN(CCCOCCCN)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C28H37N5O3/c1-3-12-33(13-6-15-36-14-5-11-29)28(35)23-17-21-9-10-22(18-25(21)32-26(30)19-23)27(34)31-24-8-4-7-20(2)16-24/h4,7-10,16-18H,3,5-6,11-15,19,29H2,1-2H3,(H2,30,32)(H,31,34)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254791
PNG
(US9475775, 58)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1ccc(CCCCCN)cc1
Show InChI InChI=1S/C29H39N5O2/c1-3-16-34(17-4-2)29(36)24-18-22-11-12-23(19-26(22)33-27(31)20-24)28(35)32-25-13-9-21(10-14-25)8-6-5-7-15-30/h9-14,18-19H,3-8,15-17,20,30H2,1-2H3,(H2,31,33)(H,32,35)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254807
PNG
(US9475775, 74)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(CCCCCCN)c1
Show InChI InChI=1S/C29H40N6O2/c1-3-13-35(14-4-2)29(37)24-16-22-10-11-23(17-26(22)34-27(31)18-24)28(36)33-25-15-21(19-32-20-25)9-7-5-6-8-12-30/h10-11,15-17,19-20H,3-9,12-14,18,30H2,1-2H3,(H2,31,34)(H,33,36)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


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More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254808
PNG
(US9475775, 75)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1ccc(CCCN)nc1
Show InChI InChI=1S/C26H34N6O2/c1-3-12-32(13-4-2)26(34)20-14-18-7-8-19(15-23(18)31-24(28)16-20)25(33)30-22-10-9-21(29-17-22)6-5-11-27/h7-10,14-15,17H,3-6,11-13,16,27H2,1-2H3,(H2,28,31)(H,30,33)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254742
PNG
(US9475775, 9)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncs1
Show InChI InChI=1S/C21H25N5O2S/c1-3-7-26(8-4-2)21(28)16-9-14-5-6-15(10-17(14)24-18(22)11-16)20(27)25-19-12-23-13-29-19/h5-6,9-10,12-13H,3-4,7-8,11H2,1-2H3,(H2,22,24)(H,25,27)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254762
PNG
(US9475775, 29)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(CC)c1
Show InChI InChI=1S/C26H32N4O2/c1-4-12-30(13-5-2)26(32)21-15-19-10-11-20(16-23(19)29-24(27)17-21)25(31)28-22-9-7-8-18(6-3)14-22/h7-11,14-16H,4-6,12-13,17H2,1-3H3,(H2,27,29)(H,28,31)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254764
PNG
(US9475775, 31)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H27F3N4O2/c1-3-10-32(11-4-2)24(34)18-12-16-8-9-17(13-21(16)31-22(29)14-18)23(33)30-20-7-5-6-19(15-20)25(26,27)28/h5-9,12-13,15H,3-4,10-11,14H2,1-2H3,(H2,29,31)(H,30,33)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254765
PNG
(US9475775, 32)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(Cl)c1
Show InChI InChI=1S/C24H27ClN4O2/c1-3-10-29(11-4-2)24(31)18-12-16-8-9-17(13-21(16)28-22(26)14-18)23(30)27-20-7-5-6-19(25)15-20/h5-9,12-13,15H,3-4,10-11,14H2,1-2H3,(H2,26,28)(H,27,30)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254777
PNG
(US9475775, 44 | US9475775, 79)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(OCC)c1
Show InChI InChI=1S/C25H31N5O3/c1-4-9-30(10-5-2)25(32)19-11-17-7-8-18(12-22(17)29-23(26)13-19)24(31)28-20-14-21(33-6-3)16-27-15-20/h7-8,11-12,14-16H,4-6,9-10,13H2,1-3H3,(H2,26,29)(H,28,31)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254791
PNG
(US9475775, 58)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1ccc(CCCCCN)cc1
Show InChI InChI=1S/C29H39N5O2/c1-3-16-34(17-4-2)29(36)24-18-22-11-12-23(19-26(22)33-27(31)20-24)28(35)32-25-13-9-21(10-14-25)8-6-5-7-15-30/h9-14,18-19H,3-8,15-17,20,30H2,1-2H3,(H2,31,33)(H,32,35)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254805
PNG
(US9475775, 72)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(CCCCCN)c1
Show InChI InChI=1S/C28H38N6O2/c1-3-12-34(13-4-2)28(36)23-15-21-9-10-22(16-25(21)33-26(30)17-23)27(35)32-24-14-20(18-31-19-24)8-6-5-7-11-29/h9-10,14-16,18-19H,3-8,11-13,17,29H2,1-2H3,(H2,30,33)(H,32,35)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254806
PNG
(US9475775, 73)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(CCc2cccc(OC)c2)c1
Show InChI InChI=1S/C32H37N5O3/c1-4-13-37(14-5-2)32(39)26-17-24-11-12-25(18-29(24)36-30(33)19-26)31(38)35-27-15-23(20-34-21-27)10-9-22-7-6-8-28(16-22)40-3/h6-8,11-12,15-18,20-21H,4-5,9-10,13-14,19H2,1-3H3,(H2,33,36)(H,35,38)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254807
PNG
(US9475775, 74)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(CCCCCCN)c1
Show InChI InChI=1S/C29H40N6O2/c1-3-13-35(14-4-2)29(37)24-16-22-10-11-23(17-26(22)34-27(31)18-24)28(36)33-25-15-21(19-32-20-25)9-7-5-6-8-12-30/h10-11,15-17,19-20H,3-9,12-14,18,30H2,1-2H3,(H2,31,34)(H,33,36)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254734
PNG
(US9475775, 1)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccnc1
Show InChI InChI=1S/C23H27N5O2/c1-3-10-28(11-4-2)23(30)18-12-16-7-8-17(13-20(16)27-21(24)14-18)22(29)26-19-6-5-9-25-15-19/h5-9,12-13,15H,3-4,10-11,14H2,1-2H3,(H2,24,27)(H,26,29)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254738
PNG
(US9475775, 5)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1ccc(CN)nc1
Show InChI InChI=1S/C24H30N6O2/c1-3-9-30(10-4-2)24(32)18-11-16-5-6-17(12-21(16)29-22(26)13-18)23(31)28-20-8-7-19(14-25)27-15-20/h5-8,11-12,15H,3-4,9-10,13-14,25H2,1-2H3,(H2,26,29)(H,28,31)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254773
PNG
(US9475775, 40)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(OC)c1
Show InChI InChI=1S/C24H29N5O3/c1-4-8-29(9-5-2)24(31)18-10-16-6-7-17(11-21(16)28-22(25)12-18)23(30)27-19-13-20(32-3)15-26-14-19/h6-7,10-11,13-15H,4-5,8-9,12H2,1-3H3,(H2,25,28)(H,27,30)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254783
PNG
(US9475775, 50)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(CCCN)c1
Show InChI InChI=1S/C26H34N6O2/c1-3-10-32(11-4-2)26(34)21-13-19-7-8-20(14-23(19)31-24(28)15-21)25(33)30-22-12-18(6-5-9-27)16-29-17-22/h7-8,12-14,16-17H,3-6,9-11,15,27H2,1-2H3,(H2,28,31)(H,30,33)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254795
PNG
(US9475775, 62)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(CCCCN)c1
Show InChI InChI=1S/C28H37N5O2/c1-3-14-33(15-4-2)28(35)23-17-21-11-12-22(18-25(21)32-26(30)19-23)27(34)31-24-10-7-9-20(16-24)8-5-6-13-29/h7,9-12,16-18H,3-6,8,13-15,19,29H2,1-2H3,(H2,30,32)(H,31,34)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254796
PNG
(US9475775, 63)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1ccc(F)c(CCN)c1
Show InChI InChI=1S/C26H32FN5O2/c1-3-11-32(12-4-2)26(34)20-13-18-5-6-19(15-23(18)31-24(29)16-20)25(33)30-21-7-8-22(27)17(14-21)9-10-28/h5-8,13-15H,3-4,9-12,16,28H2,1-2H3,(H2,29,31)(H,30,33)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254800
PNG
(US9475775, 67)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(CNC(=O)OCc2ccccc2)c1
Show InChI InChI=1S/C32H36N6O4/c1-3-12-38(13-4-2)31(40)26-15-24-10-11-25(16-28(24)37-29(33)17-26)30(39)36-27-14-23(18-34-20-27)19-35-32(41)42-21-22-8-6-5-7-9-22/h5-11,14-16,18,20H,3-4,12-13,17,19,21H2,1-2H3,(H2,33,37)(H,35,41)(H,36,39)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254813
PNG
(US9475775, 80)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(CCN)c1
Show InChI InChI=1S/C25H32N6O2/c1-3-9-31(10-4-2)25(33)20-12-18-5-6-19(13-22(18)30-23(27)14-20)24(32)29-21-11-17(7-8-26)15-28-16-21/h5-6,11-13,15-16H,3-4,7-10,14,26H2,1-2H3,(H2,27,30)(H,29,32)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254754
PNG
(US9475775, 21)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccnc1C
Show InChI InChI=1S/C24H29N5O2/c1-4-11-29(12-5-2)24(31)19-13-17-8-9-18(14-21(17)27-22(25)15-19)23(30)28-20-7-6-10-26-16(20)3/h6-10,13-14H,4-5,11-12,15H2,1-3H3,(H2,25,27)(H,28,30)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254761
PNG
(US9475775, 28)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1ccc(C)cc1
Show InChI InChI=1S/C25H30N4O2/c1-4-12-29(13-5-2)25(31)20-14-18-8-9-19(15-22(18)28-23(26)16-20)24(30)27-21-10-6-17(3)7-11-21/h6-11,14-15H,4-5,12-13,16H2,1-3H3,(H2,26,28)(H,27,30)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254763
PNG
(US9475775, 30)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(OC)c1
Show InChI InChI=1S/C25H30N4O3/c1-4-11-29(12-5-2)25(31)19-13-17-9-10-18(14-22(17)28-23(26)15-19)24(30)27-20-7-6-8-21(16-20)32-3/h6-10,13-14,16H,4-5,11-12,15H2,1-3H3,(H2,26,28)(H,27,30)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254772
PNG
(US9475775, 39)
Show SMILES CCCN(CCCO)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccnc1
Show InChI InChI=1S/C23H27N5O3/c1-2-9-28(10-4-11-29)23(31)18-12-16-6-7-17(13-20(16)27-21(24)14-18)22(30)26-19-5-3-8-25-15-19/h3,5-8,12-13,15,29H,2,4,9-11,14H2,1H3,(H2,24,27)(H,26,30)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254783
PNG
(US9475775, 50)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(CCCN)c1
Show InChI InChI=1S/C26H34N6O2/c1-3-10-32(11-4-2)26(34)21-13-19-7-8-20(14-23(19)31-24(28)15-21)25(33)30-22-12-18(6-5-9-27)16-29-17-22/h7-8,12-14,16-17H,3-6,9-11,15,27H2,1-2H3,(H2,28,31)(H,30,33)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254784
PNG
(US9475775, 51)
Show SMILES CCCN(CCC(F)(F)F)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C25H27F3N4O2/c1-3-10-32(11-9-25(26,27)28)24(34)19-13-17-7-8-18(14-21(17)31-22(29)15-19)23(33)30-20-6-4-5-16(2)12-20/h4-8,12-14H,3,9-11,15H2,1-2H3,(H2,29,31)(H,30,33)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254785
PNG
(US9475775, 52)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(\C=C/CN)c1
Show InChI InChI=1S/C26H32N6O2/c1-3-10-32(11-4-2)26(34)21-13-19-7-8-20(14-23(19)31-24(28)15-21)25(33)30-22-12-18(6-5-9-27)16-29-17-22/h5-8,12-14,16-17H,3-4,9-11,15,27H2,1-2H3,(H2,28,31)(H,30,33)/b6-5-
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254797
PNG
(US9475775, 64)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cc(Cl)cc(CCN)c1
Show InChI InChI=1S/C26H32ClN5O2/c1-3-9-32(10-4-2)26(34)20-13-18-5-6-19(14-23(18)31-24(29)15-20)25(33)30-22-12-17(7-8-28)11-21(27)16-22/h5-6,11-14,16H,3-4,7-10,15,28H2,1-2H3,(H2,29,31)(H,30,33)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254809
PNG
(US9475775, 76)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(CCCCN)c1
Show InChI InChI=1S/C27H36N6O2/c1-3-11-33(12-4-2)27(35)22-14-20-8-9-21(15-24(20)32-25(29)16-22)26(34)31-23-13-19(17-30-18-23)7-5-6-10-28/h8-9,13-15,17-18H,3-7,10-12,16,28H2,1-2H3,(H2,29,32)(H,31,34)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254810
PNG
(US9475775, 77)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1ccc(CCCCN)nc1
Show InChI InChI=1S/C27H36N6O2/c1-3-13-33(14-4-2)27(35)21-15-19-8-9-20(16-24(19)32-25(29)17-21)26(34)31-23-11-10-22(30-18-23)7-5-6-12-28/h8-11,15-16,18H,3-7,12-14,17,28H2,1-2H3,(H2,29,32)(H,31,34)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254740
PNG
(US9475775, 7)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1ccc(CO)nc1
Show InChI InChI=1S/C24H29N5O3/c1-3-9-29(10-4-2)24(32)18-11-16-5-6-17(12-21(16)28-22(25)13-18)23(31)27-19-7-8-20(15-30)26-14-19/h5-8,11-12,14,30H,3-4,9-10,13,15H2,1-2H3,(H2,25,28)(H,27,31)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254742
PNG
(US9475775, 9)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncs1
Show InChI InChI=1S/C21H25N5O2S/c1-3-7-26(8-4-2)21(28)16-9-14-5-6-15(10-17(14)24-18(22)11-16)20(27)25-19-12-23-13-29-19/h5-6,9-10,12-13H,3-4,7-8,11H2,1-2H3,(H2,22,24)(H,25,27)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254753
PNG
(US9475775, 20)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(F)c1
Show InChI InChI=1S/C23H26FN5O2/c1-3-7-29(8-4-2)23(31)17-9-15-5-6-16(10-20(15)28-21(25)11-17)22(30)27-19-12-18(24)13-26-14-19/h5-6,9-10,12-14H,3-4,7-8,11H2,1-2H3,(H2,25,28)(H,27,30)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254754
PNG
(US9475775, 21)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccnc1C
Show InChI InChI=1S/C24H29N5O2/c1-4-11-29(12-5-2)24(31)19-13-17-8-9-18(14-21(17)27-22(25)15-19)23(30)28-20-7-6-10-26-16(20)3/h6-10,13-14H,4-5,11-12,15H2,1-3H3,(H2,25,27)(H,28,30)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254755
PNG
(US9475775, 22)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1ccc(C)nc1
Show InChI InChI=1S/C24H29N5O2/c1-4-10-29(11-5-2)24(31)19-12-17-7-8-18(13-21(17)28-22(25)14-19)23(30)27-20-9-6-16(3)26-15-20/h6-9,12-13,15H,4-5,10-11,14H2,1-3H3,(H2,25,28)(H,27,30)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254771
PNG
(US9475775, 38)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1ncco1
Show InChI InChI=1S/C21H25N5O3/c1-3-8-26(9-4-2)20(28)16-11-14-5-6-15(12-17(14)24-18(22)13-16)19(27)25-21-23-7-10-29-21/h5-7,10-12H,3-4,8-9,13H2,1-2H3,(H2,22,24)(H,23,25,27)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254785
PNG
(US9475775, 52)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(\C=C/CN)c1
Show InChI InChI=1S/C26H32N6O2/c1-3-10-32(11-4-2)26(34)21-13-19-7-8-20(14-23(19)31-24(28)15-21)25(33)30-22-12-18(6-5-9-27)16-29-17-22/h5-8,12-14,16-17H,3-4,9-11,15,27H2,1-2H3,(H2,28,31)(H,30,33)/b6-5-
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254750
PNG
(US9475775, 17 | US9475775, 54)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(CCN)c1
Show InChI InChI=1S/C26H33N5O2/c1-3-12-31(13-4-2)26(33)21-15-19-8-9-20(16-23(19)30-24(28)17-21)25(32)29-22-7-5-6-18(14-22)10-11-27/h5-9,14-16H,3-4,10-13,17,27H2,1-2H3,(H2,28,30)(H,29,32)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254738
PNG
(US9475775, 5)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1ccc(CN)nc1
Show InChI InChI=1S/C24H30N6O2/c1-3-9-30(10-4-2)24(32)18-11-16-5-6-17(12-21(16)29-22(26)13-18)23(31)28-20-8-7-19(14-25)27-15-20/h5-8,11-12,15H,3-4,9-10,13-14,25H2,1-2H3,(H2,26,29)(H,28,31)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254741
PNG
(US9475775, 8)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(c1)S(C)(=O)=O
Show InChI InChI=1S/C25H30N4O4S/c1-4-11-29(12-5-2)25(31)19-13-17-9-10-18(14-22(17)28-23(26)15-19)24(30)27-20-7-6-8-21(16-20)34(3,32)33/h6-10,13-14,16H,4-5,11-12,15H2,1-3H3,(H2,26,28)(H,27,30)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254743
PNG
(US9475775, 10)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C24H27ClN4O2/c1-3-11-29(12-4-2)24(31)18-13-16-5-6-17(14-21(16)28-22(26)15-18)23(30)27-20-9-7-19(25)8-10-20/h5-10,13-14H,3-4,11-12,15H2,1-2H3,(H2,26,28)(H,27,30)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254755
PNG
(US9475775, 22)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1ccc(C)nc1
Show InChI InChI=1S/C24H29N5O2/c1-4-10-29(11-5-2)24(31)19-12-17-7-8-18(13-21(17)28-22(25)14-19)23(30)27-20-9-6-16(3)26-15-20/h6-9,12-13,15H,4-5,10-11,14H2,1-3H3,(H2,25,28)(H,27,30)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254766
PNG
(US9475775, 33)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(CN)c1
Show InChI InChI=1S/C24H30N6O2/c1-3-7-30(8-4-2)24(32)19-10-17-5-6-18(11-21(17)29-22(26)12-19)23(31)28-20-9-16(13-25)14-27-15-20/h5-6,9-11,14-15H,3-4,7-8,12-13,25H2,1-2H3,(H2,26,29)(H,28,31)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254768
PNG
(US9475775, 35)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1ccc(OCC)nc1
Show InChI InChI=1S/C25H31N5O3/c1-4-11-30(12-5-2)25(32)19-13-17-7-8-18(14-21(17)29-22(26)15-19)24(31)28-20-9-10-23(27-16-20)33-6-3/h7-10,13-14,16H,4-6,11-12,15H2,1-3H3,(H2,26,29)(H,28,31)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


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More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254769
PNG
(US9475775, 36)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(CN)c1
Show InChI InChI=1S/C25H31N5O2/c1-3-10-30(11-4-2)25(32)20-13-18-8-9-19(14-22(18)29-23(27)15-20)24(31)28-21-7-5-6-17(12-21)16-26/h5-9,12-14H,3-4,10-11,15-16,26H2,1-2H3,(H2,27,29)(H,28,31)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254771
PNG
(US9475775, 38)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1ncco1
Show InChI InChI=1S/C21H25N5O3/c1-3-8-26(9-4-2)20(28)16-11-14-5-6-15(12-17(14)24-18(22)13-16)19(27)25-21-23-7-10-29-21/h5-7,10-12H,3-4,8-9,13H2,1-2H3,(H2,22,24)(H,23,25,27)
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n/an/an/an/a 4.50E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254780
PNG
(US9475775, 47)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(COCCOCCN)c1
Show InChI InChI=1S/C29H39N5O4/c1-3-11-34(12-4-2)29(36)24-17-22-8-9-23(18-26(22)33-27(31)19-24)28(35)32-25-7-5-6-21(16-25)20-38-15-14-37-13-10-30/h5-9,16-18H,3-4,10-15,19-20,30H2,1-2H3,(H2,31,33)(H,32,35)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254789
PNG
(US9475775, 56)
Show SMILES CCCN(CCCOCCCN)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C28H37N5O3/c1-3-12-33(13-6-15-36-14-5-11-29)28(35)23-17-21-9-10-22(18-25(21)32-26(30)19-23)27(34)31-24-8-4-7-20(2)16-24/h4,7-10,16-18H,3,5-6,11-15,19,29H2,1-2H3,(H2,30,32)(H,31,34)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254798
PNG
(US9475775, 65)
Show SMILES CCCCN(CCO)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C25H30N4O3/c1-3-4-10-29(11-12-30)25(32)20-14-18-8-9-19(15-22(18)28-23(26)16-20)24(31)27-21-7-5-6-17(2)13-21/h5-9,13-15,30H,3-4,10-12,16H2,1-2H3,(H2,26,28)(H,27,31)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254800
PNG
(US9475775, 67)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(CNC(=O)OCc2ccccc2)c1
Show InChI InChI=1S/C32H36N6O4/c1-3-12-38(13-4-2)31(40)26-15-24-10-11-25(16-28(24)37-29(33)17-26)30(39)36-27-14-23(18-34-20-27)19-35-32(41)42-21-22-8-6-5-7-9-22/h5-11,14-16,18,20H,3-4,12-13,17,19,21H2,1-2H3,(H2,33,37)(H,35,41)(H,36,39)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254757
PNG
(US9475775, 24)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1ccc(CN)cc1
Show InChI InChI=1S/C25H31N5O2/c1-3-11-30(12-4-2)25(32)20-13-18-7-8-19(14-22(18)29-23(27)15-20)24(31)28-21-9-5-17(16-26)6-10-21/h5-10,13-14H,3-4,11-12,15-16,26H2,1-2H3,(H2,27,29)(H,28,31)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254760
PNG
(US9475775, 27)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1ccccc1C
Show InChI InChI=1S/C25H30N4O2/c1-4-12-29(13-5-2)25(31)20-14-18-10-11-19(15-22(18)27-23(26)16-20)24(30)28-21-9-7-6-8-17(21)3/h6-11,14-15H,4-5,12-13,16H2,1-3H3,(H2,26,27)(H,28,30)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254765
PNG
(US9475775, 32)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(Cl)c1
Show InChI InChI=1S/C24H27ClN4O2/c1-3-10-29(11-4-2)24(31)18-12-16-8-9-17(13-21(16)28-22(26)14-18)23(30)27-20-7-5-6-19(25)15-20/h5-9,12-13,15H,3-4,10-11,14H2,1-2H3,(H2,26,28)(H,27,30)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254801
PNG
(US9475775, 68)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(\C=C\CN)c1
Show InChI InChI=1S/C26H32N6O2/c1-3-10-32(11-4-2)26(34)21-13-19-7-8-20(14-23(19)31-24(28)15-21)25(33)30-22-12-18(6-5-9-27)16-29-17-22/h5-8,12-14,16-17H,3-4,9-11,15,27H2,1-2H3,(H2,28,31)(H,30,33)/b6-5+
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254804
PNG
(US9475775, 71)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(CCc2ccc(CN)cc2)c1
Show InChI InChI=1S/C32H38N6O2/c1-3-13-38(14-4-2)32(40)27-16-25-11-12-26(17-29(25)37-30(34)18-27)31(39)36-28-15-24(20-35-21-28)10-7-22-5-8-23(19-33)9-6-22/h5-6,8-9,11-12,15-17,20-21H,3-4,7,10,13-14,18-19,33H2,1-2H3,(H2,34,37)(H,36,39)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254734
PNG
(US9475775, 1)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccnc1
Show InChI InChI=1S/C23H27N5O2/c1-3-10-28(11-4-2)23(30)18-12-16-7-8-17(13-20(16)27-21(24)14-18)22(29)26-19-6-5-9-25-15-19/h5-9,12-13,15H,3-4,10-11,14H2,1-2H3,(H2,24,27)(H,26,29)
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n/an/an/an/a 8.08E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254735
PNG
(US9475775, 2)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncnc1
Show InChI InChI=1S/C22H26N6O2/c1-3-7-28(8-4-2)22(30)17-9-15-5-6-16(10-19(15)27-20(23)11-17)21(29)26-18-12-24-14-25-13-18/h5-6,9-10,12-14H,3-4,7-8,11H2,1-2H3,(H2,23,27)(H,26,29)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254775
PNG
(US9475775, 42)
Show SMILES CCCCN(CCCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C27H34N4O2/c1-4-6-13-31(14-7-5-2)27(33)22-16-20-11-12-21(17-24(20)30-25(28)18-22)26(32)29-23-10-8-9-19(3)15-23/h8-12,15-17H,4-7,13-14,18H2,1-3H3,(H2,28,30)(H,29,32)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254778
PNG
(US9475775, 45)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(OCCOCCN)c1
Show InChI InChI=1S/C28H37N5O4/c1-3-11-33(12-4-2)28(35)22-16-20-8-9-21(17-25(20)32-26(30)18-22)27(34)31-23-6-5-7-24(19-23)37-15-14-36-13-10-29/h5-9,16-17,19H,3-4,10-15,18,29H2,1-2H3,(H2,30,32)(H,31,34)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254794
PNG
(US9475775, 61)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1ccc(CCCN)cc1
Show InChI InChI=1S/C27H35N5O2/c1-3-14-32(15-4-2)27(34)22-16-20-9-10-21(17-24(20)31-25(29)18-22)26(33)30-23-11-7-19(8-12-23)6-5-13-28/h7-12,16-17H,3-6,13-15,18,28H2,1-2H3,(H2,29,31)(H,30,33)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254795
PNG
(US9475775, 62)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(CCCCN)c1
Show InChI InChI=1S/C28H37N5O2/c1-3-14-33(15-4-2)28(35)23-17-21-11-12-22(18-25(21)32-26(30)19-23)27(34)31-24-10-7-9-20(16-24)8-5-6-13-29/h7,9-12,16-18H,3-6,8,13-15,19,29H2,1-2H3,(H2,30,32)(H,31,34)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254796
PNG
(US9475775, 63)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1ccc(F)c(CCN)c1
Show InChI InChI=1S/C26H32FN5O2/c1-3-11-32(12-4-2)26(34)20-13-18-5-6-19(15-23(18)31-24(29)16-20)25(33)30-21-7-8-22(27)17(14-21)9-10-28/h5-8,13-15H,3-4,9-12,16,28H2,1-2H3,(H2,29,31)(H,30,33)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254808
PNG
(US9475775, 75)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1ccc(CCCN)nc1
Show InChI InChI=1S/C26H34N6O2/c1-3-12-32(13-4-2)26(34)20-14-18-7-8-19(15-23(18)31-24(28)16-20)25(33)30-22-10-9-21(29-17-22)6-5-11-27/h7-10,14-15,17H,3-6,11-13,16,27H2,1-2H3,(H2,28,31)(H,30,33)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254744
PNG
(US9475775, 11)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1nccs1
Show InChI InChI=1S/C21H25N5O2S/c1-3-8-26(9-4-2)20(28)16-11-14-5-6-15(12-17(14)24-18(22)13-16)19(27)25-21-23-7-10-29-21/h5-7,10-12H,3-4,8-9,13H2,1-2H3,(H2,22,24)(H,23,25,27)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254777
PNG
(US9475775, 44 | US9475775, 79)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(OCC)c1
Show InChI InChI=1S/C25H31N5O3/c1-4-9-30(10-5-2)25(32)19-11-17-7-8-18(12-22(17)29-23(26)13-19)24(31)28-20-14-21(33-6-3)16-27-15-20/h7-8,11-12,14-16H,4-6,9-10,13H2,1-3H3,(H2,26,29)(H,28,31)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254736
PNG
(US9475775, 3)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1ccncc1
Show InChI InChI=1S/C23H27N5O2/c1-3-11-28(12-4-2)23(30)18-13-16-5-6-17(14-20(16)27-21(24)15-18)22(29)26-19-7-9-25-10-8-19/h5-10,13-14H,3-4,11-12,15H2,1-2H3,(H2,24,27)(H,25,26,29)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254743
PNG
(US9475775, 10)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C24H27ClN4O2/c1-3-11-29(12-4-2)24(31)18-13-16-5-6-17(14-21(16)28-22(26)15-18)23(30)27-20-9-7-19(25)8-10-20/h5-10,13-14H,3-4,11-12,15H2,1-2H3,(H2,26,28)(H,27,30)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254744
PNG
(US9475775, 11)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1nccs1
Show InChI InChI=1S/C21H25N5O2S/c1-3-8-26(9-4-2)20(28)16-11-14-5-6-15(12-17(14)24-18(22)13-16)19(27)25-21-23-7-10-29-21/h5-7,10-12H,3-4,8-9,13H2,1-2H3,(H2,22,24)(H,23,25,27)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254747
PNG
(US9475775, 14)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C25H30N4O2/c1-4-11-29(12-5-2)25(31)20-14-18-9-10-19(15-22(18)28-23(26)16-20)24(30)27-21-8-6-7-17(3)13-21/h6-10,13-15H,4-5,11-12,16H2,1-3H3,(H2,26,28)(H,27,30)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254752
PNG
(US9475775, 19)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(F)c1
Show InChI InChI=1S/C24H27FN4O2/c1-3-10-29(11-4-2)24(31)18-12-16-8-9-17(13-21(16)28-22(26)14-18)23(30)27-20-7-5-6-19(25)15-20/h5-9,12-13,15H,3-4,10-11,14H2,1-2H3,(H2,26,28)(H,27,30)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254761
PNG
(US9475775, 28)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1ccc(C)cc1
Show InChI InChI=1S/C25H30N4O2/c1-4-12-29(13-5-2)25(31)20-14-18-8-9-19(15-22(18)28-23(26)16-20)24(30)27-21-10-6-17(3)7-11-21/h6-11,14-15H,4-5,12-13,16H2,1-3H3,(H2,26,28)(H,27,30)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254764
PNG
(US9475775, 31)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H27F3N4O2/c1-3-10-32(11-4-2)24(34)18-12-16-8-9-17(13-21(16)31-22(29)14-18)23(33)30-20-7-5-6-19(15-20)25(26,27)28/h5-9,12-13,15H,3-4,10-11,14H2,1-2H3,(H2,29,31)(H,30,33)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254769
PNG
(US9475775, 36)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(CN)c1
Show InChI InChI=1S/C25H31N5O2/c1-3-10-30(11-4-2)25(32)20-13-18-8-9-19(14-22(18)29-23(27)15-20)24(31)28-21-7-5-6-17(12-21)16-26/h5-9,12-14H,3-4,10-11,15-16,26H2,1-2H3,(H2,27,29)(H,28,31)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254774
PNG
(US9475775, 41)
Show SMILES CCCN(CC#C)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C25H26N4O2/c1-4-11-29(12-5-2)25(31)20-14-18-9-10-19(15-22(18)28-23(26)16-20)24(30)27-21-8-6-7-17(3)13-21/h1,6-10,13-15H,5,11-12,16H2,2-3H3,(H2,26,28)(H,27,30)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254775
PNG
(US9475775, 42)
Show SMILES CCCCN(CCCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C27H34N4O2/c1-4-6-13-31(14-7-5-2)27(33)22-16-20-11-12-21(17-24(20)30-25(28)18-22)26(32)29-23-10-8-9-19(3)15-23/h8-12,15-17H,4-7,13-14,18H2,1-3H3,(H2,28,30)(H,29,32)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254776
PNG
(US9475775, 43)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cc(C)cc(CN)c1
Show InChI InChI=1S/C26H33N5O2/c1-4-8-31(9-5-2)26(33)21-13-19-6-7-20(14-23(19)30-24(28)15-21)25(32)29-22-11-17(3)10-18(12-22)16-27/h6-7,10-14H,4-5,8-9,15-16,27H2,1-3H3,(H2,28,30)(H,29,32)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254779
PNG
(US9475775, 46)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(OCCCCCN)c1
Show InChI InChI=1S/C28H38N6O3/c1-3-11-34(12-4-2)28(36)22-14-20-8-9-21(15-25(20)33-26(30)16-22)27(35)32-23-17-24(19-31-18-23)37-13-7-5-6-10-29/h8-9,14-15,17-19H,3-7,10-13,16,29H2,1-2H3,(H2,30,33)(H,32,35)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254784
PNG
(US9475775, 51)
Show SMILES CCCN(CCC(F)(F)F)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C25H27F3N4O2/c1-3-10-32(11-9-25(26,27)28)24(34)19-13-17-7-8-18(14-21(17)31-22(29)15-19)23(33)30-20-6-4-5-16(2)12-20/h4-8,12-14H,3,9-11,15H2,1-2H3,(H2,29,31)(H,30,33)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254786
PNG
(US9475775, 53)
Show SMILES CCCN(CC1CC1)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C26H30N4O2/c1-3-11-30(16-18-7-8-18)26(32)21-13-19-9-10-20(14-23(19)29-24(27)15-21)25(31)28-22-6-4-5-17(2)12-22/h4-6,9-10,12-14,18H,3,7-8,11,15-16H2,1-2H3,(H2,27,29)(H,28,31)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254790
PNG
(US9475775, 57)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(CCCCCN)c1
Show InChI InChI=1S/C29H39N5O2/c1-3-15-34(16-4-2)29(36)24-18-22-12-13-23(19-26(22)33-27(31)20-24)28(35)32-25-11-8-10-21(17-25)9-6-5-7-14-30/h8,10-13,17-19H,3-7,9,14-16,20,30H2,1-2H3,(H2,31,33)(H,32,35)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254810
PNG
(US9475775, 77)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1ccc(CCCCN)nc1
Show InChI InChI=1S/C27H36N6O2/c1-3-13-33(14-4-2)27(35)21-15-19-8-9-20(16-24(19)32-25(29)17-21)26(34)31-23-11-10-22(30-18-23)7-5-6-12-28/h8-11,15-16,18H,3-7,12-14,17,28H2,1-2H3,(H2,29,32)(H,31,34)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254736
PNG
(US9475775, 3)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1ccncc1
Show InChI InChI=1S/C23H27N5O2/c1-3-11-28(12-4-2)23(30)18-13-16-5-6-17(14-20(16)27-21(24)15-18)22(29)26-19-7-9-25-10-8-19/h5-10,13-14H,3-4,11-12,15H2,1-2H3,(H2,24,27)(H,25,26,29)
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n/an/an/an/a 7.01E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254748
PNG
(US9475775, 15)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(c1)C(=O)N1CCCC1
Show InChI InChI=1S/C29H35N5O3/c1-3-12-33(13-4-2)29(37)23-16-20-10-11-21(18-25(20)32-26(30)19-23)27(35)31-24-9-7-8-22(17-24)28(36)34-14-5-6-15-34/h7-11,16-18H,3-6,12-15,19H2,1-2H3,(H2,30,32)(H,31,35)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254751
PNG
(US9475775, 18)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(C)c1
Show InChI InChI=1S/C24H29N5O2/c1-4-8-29(9-5-2)24(31)19-11-17-6-7-18(12-21(17)28-22(25)13-19)23(30)27-20-10-16(3)14-26-15-20/h6-7,10-12,14-15H,4-5,8-9,13H2,1-3H3,(H2,25,28)(H,27,30)
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n/an/an/an/a 3.40E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254758
PNG
(US9475775, 25)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1ccc(CCN)cc1
Show InChI InChI=1S/C26H33N5O2/c1-3-13-31(14-4-2)26(33)21-15-19-7-8-20(16-23(19)30-24(28)17-21)25(32)29-22-9-5-18(6-10-22)11-12-27/h5-10,15-16H,3-4,11-14,17,27H2,1-2H3,(H2,28,30)(H,29,32)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254781
PNG
(US9475775, 48)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(c1)C#CCN
Show InChI InChI=1S/C26H30N6O2/c1-3-10-32(11-4-2)26(34)21-13-19-7-8-20(14-23(19)31-24(28)15-21)25(33)30-22-12-18(6-5-9-27)16-29-17-22/h7-8,12-14,16-17H,3-4,9-11,15,27H2,1-2H3,(H2,28,31)(H,30,33)
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n/an/an/an/a>1.00E+5n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254804
PNG
(US9475775, 71)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(CCc2ccc(CN)cc2)c1
Show InChI InChI=1S/C32H38N6O2/c1-3-13-38(14-4-2)32(40)27-16-25-11-12-26(17-29(25)37-30(34)18-27)31(39)36-28-15-24(20-35-21-28)10-7-22-5-8-23(19-33)9-6-22/h5-6,8-9,11-12,15-17,20-21H,3-4,7,10,13-14,18-19,33H2,1-2H3,(H2,34,37)(H,36,39)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254813
PNG
(US9475775, 80)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(CCN)c1
Show InChI InChI=1S/C25H32N6O2/c1-3-9-31(10-4-2)25(33)20-12-18-5-6-19(13-22(18)30-23(27)14-20)24(32)29-21-11-17(7-8-26)15-28-16-21/h5-6,11-13,15-16H,3-4,7-10,14,26H2,1-2H3,(H2,27,30)(H,29,32)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254758
PNG
(US9475775, 25)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1ccc(CCN)cc1
Show InChI InChI=1S/C26H33N5O2/c1-3-13-31(14-4-2)26(33)21-15-19-7-8-20(16-23(19)30-24(28)17-21)25(32)29-22-9-5-18(6-10-22)11-12-27/h5-10,15-16H,3-4,11-14,17,27H2,1-2H3,(H2,28,30)(H,29,32)
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n/an/an/an/a 18n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254768
PNG
(US9475775, 35)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1ccc(OCC)nc1
Show InChI InChI=1S/C25H31N5O3/c1-4-11-30(12-5-2)25(32)19-13-17-7-8-18(14-21(17)29-22(26)15-19)24(31)28-20-9-10-23(27-16-20)33-6-3/h7-10,13-14,16H,4-6,11-12,15H2,1-3H3,(H2,26,29)(H,28,31)
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n/an/an/an/a 1n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254781
PNG
(US9475775, 48)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(c1)C#CCN
Show InChI InChI=1S/C26H30N6O2/c1-3-10-32(11-4-2)26(34)21-13-19-7-8-20(14-23(19)31-24(28)15-21)25(33)30-22-12-18(6-5-9-27)16-29-17-22/h7-8,12-14,16-17H,3-4,9-11,15,27H2,1-2H3,(H2,28,31)(H,30,33)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254782
PNG
(US9475775, 49)
Show SMILES CCCN(CCCOCCOCCN)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C29H39N5O4/c1-3-11-34(12-5-13-37-15-16-38-14-10-30)29(36)24-18-22-8-9-23(19-26(22)33-27(31)20-24)28(35)32-25-7-4-6-21(2)17-25/h4,6-9,17-19H,3,5,10-16,20,30H2,1-2H3,(H2,31,33)(H,32,35)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254792
PNG
(US9475775, 59)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(CCCN)c1
Show InChI InChI=1S/C27H35N5O2/c1-3-13-32(14-4-2)27(34)22-16-20-10-11-21(17-24(20)31-25(29)18-22)26(33)30-23-9-5-7-19(15-23)8-6-12-28/h5,7,9-11,15-17H,3-4,6,8,12-14,18,28H2,1-2H3,(H2,29,31)(H,30,33)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254797
PNG
(US9475775, 64)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cc(Cl)cc(CCN)c1
Show InChI InChI=1S/C26H32ClN5O2/c1-3-9-32(10-4-2)26(34)20-13-18-5-6-19(14-23(18)31-24(29)15-20)25(33)30-22-12-17(7-8-28)11-21(27)16-22/h5-6,11-14,16H,3-4,7-10,15,28H2,1-2H3,(H2,29,31)(H,30,33)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254799
PNG
(US9475775, 66)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(OCCN)c1
Show InChI InChI=1S/C25H32N6O3/c1-3-8-31(9-4-2)25(33)19-11-17-5-6-18(12-22(17)30-23(27)13-19)24(32)29-20-14-21(16-28-15-20)34-10-7-26/h5-6,11-12,14-16H,3-4,7-10,13,26H2,1-2H3,(H2,27,30)(H,29,32)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM254777
PNG
(US9475775, 44 | US9475775, 79)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(OCC)c1
Show InChI InChI=1S/C25H31N5O3/c1-4-9-30(10-5-2)25(32)19-11-17-7-8-18(12-22(17)29-23(26)13-19)24(31)28-20-14-21(33-6-3)16-27-15-20/h7-8,11-12,14-16H,4-6,9-10,13H2,1-3H3,(H2,26,29)(H,28,31)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254739
PNG
(US9475775, 6)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(CO)c1
Show InChI InChI=1S/C24H29N5O3/c1-3-7-29(8-4-2)24(32)19-10-17-5-6-18(11-21(17)28-22(25)12-19)23(31)27-20-9-16(15-30)13-26-14-20/h5-6,9-11,13-14,30H,3-4,7-8,12,15H2,1-2H3,(H2,25,28)(H,27,31)
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n/an/an/an/a>1.00E+5n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
Toll-like receptor 7 (TLR7)


(Homo sapiens (Human))
BDBM254740
PNG
(US9475775, 7)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1ccc(CO)nc1
Show InChI InChI=1S/C24H29N5O3/c1-3-9-29(10-4-2)24(32)18-11-16-5-6-17(12-21(16)28-22(25)13-18)23(31)27-19-7-8-20(15-30)26-14-19/h5-8,11-12,14,30H,3-4,9-10,13,15H2,1-2H3,(H2,25,28)(H,27,31)
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n/an/an/an/a>1.00E+5n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%