BindingDB logo
myBDB logout

Patent code US9475806

Compile Data Set for Download or QSAR
Found 21 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Complement factor B


(Homo sapiens (Human))
BDBM251876
PNG
(US9475806, 9-D b) (-))
Show SMILES CNC(c1nc2cc(cnc2[nH]1)C#N)(c1c(OC)cc(C)c2[nH]ccc12)C(F)(F)F
Show InChI InChI=1S/C20H17F3N6O/c1-10-6-14(30-3)15(12-4-5-26-16(10)12)19(25-2,20(21,22)23)18-28-13-7-11(8-24)9-27-17(13)29-18/h4-7,9,25-26H,1-3H3,(H,27,28,29)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 30n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Recombinant human factor B (expressed in drosophila cells and purified using standard methods) labeled with biotin (10 nM), europium-labeled streptav...


Citation and Details
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM251874
PNG
(US9475806, 8-B b) (-))
Show SMILES COc1cc(C)c2[nH]ccc2c1C(C)(OC)c1nc2cc(cnc2[nH]1)C#N
Show InChI InChI=1S/C20H19N5O2/c1-11-7-15(26-3)16(13-5-6-22-17(11)13)20(2,27-4)19-24-14-8-12(9-21)10-23-18(14)25-19/h5-8,10,22H,1-4H3,(H,23,24,25)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 30n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Recombinant human factor B (expressed in drosophila cells and purified using standard methods) labeled with biotin (10 nM), europium-labeled streptav...


Citation and Details
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM251878
PNG
(US9475806, 10-B b) (-))
Show SMILES COc1cc(C)c2[nH]ccc2c1C(C)(N)c1nc2cc(cnc2[nH]1)C#N
Show InChI InChI=1S/C19H18N6O/c1-10-6-14(26-3)15(12-4-5-22-16(10)12)19(2,21)18-24-13-7-11(8-20)9-23-17(13)25-18/h4-7,9,22H,21H2,1-3H3,(H,23,24,25)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 40n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Recombinant human factor B (expressed in drosophila cells and purified using standard methods) labeled with biotin (10 nM), europium-labeled streptav...


Citation and Details
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM251882
PNG
(US9475806, 12-D)
Show SMILES COc1cc(C)c2[nH]ccc2c1C(C)(C)c1nc2cc(cnc2[nH]1)C#N
Show InChI InChI=1S/C20H19N5O/c1-11-7-15(26-4)16(13-5-6-22-17(11)13)20(2,3)19-24-14-8-12(9-21)10-23-18(14)25-19/h5-8,10,22H,1-4H3,(H,23,24,25)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 40n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Recombinant human factor B (expressed in drosophila cells and purified using standard methods) labeled with biotin (10 nM), europium-labeled streptav...


Citation and Details
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM251873
PNG
(US9475806, 7-D b) (+))
Show SMILES COc1cc(C)c2[nH]ccc2c1C(C)(O)c1nc2cc(cnc2[nH]1)C#N
Show InChI InChI=1S/C19H17N5O2/c1-10-6-14(26-3)15(12-4-5-21-16(10)12)19(2,25)18-23-13-7-11(8-20)9-22-17(13)24-18/h4-7,9,21,25H,1-3H3,(H,22,23,24)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Recombinant human factor B (expressed in drosophila cells and purified using standard methods) labeled with biotin (10 nM), europium-labeled streptav...


Citation and Details
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM251887
PNG
(US9475806, 17-C)
Show SMILES Cc1cc(C2CC2)c(c2cc[nH]c12)C(C)(O)c1nc2cc(cnc2[nH]1)C#N
Show InChI InChI=1S/C21H19N5O/c1-11-7-15(13-3-4-13)17(14-5-6-23-18(11)14)21(2,27)20-25-16-8-12(9-22)10-24-19(16)26-20/h5-8,10,13,23,27H,3-4H2,1-2H3,(H,24,25,26)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 60n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Recombinant human factor B (expressed in drosophila cells and purified using standard methods) labeled with biotin (10 nM), europium-labeled streptav...


Citation and Details
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM251870
PNG
(US9475806, 6-C b) (-))
Show SMILES COc1cc(C)c2[nH]ccc2c1C(O)c1nc2ncc(cc2[nH]1)C#N
Show InChI InChI=1S/C18H15N5O2/c1-9-5-13(25-2)14(11-3-4-20-15(9)11)16(24)18-22-12-6-10(7-19)8-21-17(12)23-18/h3-6,8,16,20,24H,1-2H3,(H,21,22,23)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 90n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Recombinant human factor B (expressed in drosophila cells and purified using standard methods) labeled with biotin (10 nM), europium-labeled streptav...


Citation and Details
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM251888
PNG
(US9475806, 17-G)
Show SMILES Cc1cc(C2CC2)c(c2cc[nH]c12)C(N)(c1nc2cc(cnc2[nH]1)C#N)C(F)(F)F
Show InChI InChI=1S/C21H17F3N6/c1-10-6-14(12-2-3-12)16(13-4-5-27-17(10)13)20(26,21(22,23)24)19-29-15-7-11(8-25)9-28-18(15)30-19/h4-7,9,12,27H,2-3,26H2,1H3,(H,28,29,30)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 90n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Recombinant human factor B (expressed in drosophila cells and purified using standard methods) labeled with biotin (10 nM), europium-labeled streptav...


Citation and Details
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM251883
PNG
(US9475806, 14-I b) (-))
Show SMILES CCc1cc(C)c2[nH]ccc2c1C(O)(c1nc2cc(cnc2[nH]1)C#N)C(F)(F)F
Show InChI InChI=1S/C20H16F3N5O/c1-3-12-6-10(2)16-13(4-5-25-16)15(12)19(29,20(21,22)23)18-27-14-7-11(8-24)9-26-17(14)28-18/h4-7,9,25,29H,3H2,1-2H3,(H,26,27,28)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Recombinant human factor B (expressed in drosophila cells and purified using standard methods) labeled with biotin (10 nM), europium-labeled streptav...


Citation and Details
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM251872
PNG
(US9475806, 7-D b) (-))
Show SMILES COc1cc(C)c2[nH]ccc2c1C(C)(O)c1nc2cc(cnc2[nH]1)C#N
Show InChI InChI=1S/C19H17N5O2/c1-10-6-14(26-3)15(12-4-5-21-16(10)12)19(2,25)18-23-13-7-11(8-20)9-22-17(13)24-18/h4-7,9,21,25H,1-3H3,(H,22,23,24)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 130n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Recombinant human factor B (expressed in drosophila cells and purified using standard methods) labeled with biotin (10 nM), europium-labeled streptav...


Citation and Details
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM251869
PNG
(US9475806, 5-B b) (-))
Show SMILES COc1cc(C)c2[nH]ccc2c1C(N)(c1nc2cc(cnc2[nH]1)C#N)C(F)(F)F
Show InChI InChI=1S/C19H15F3N6O/c1-9-5-13(29-2)14(11-3-4-25-15(9)11)18(24,19(20,21)22)17-27-12-6-10(7-23)8-26-16(12)28-17/h3-6,8,25H,24H2,1-2H3,(H,26,27,28)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 140n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Recombinant human factor B (expressed in drosophila cells and purified using standard methods) labeled with biotin (10 nM), europium-labeled streptav...


Citation and Details
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM251868
PNG
(US9475806, 5-B b) (+))
Show SMILES COc1cc(C)c2[nH]ccc2c1C(N)(c1nc2cc(cnc2[nH]1)C#N)C(F)(F)F
Show InChI InChI=1S/C19H15F3N6O/c1-9-5-13(29-2)14(11-3-4-25-15(9)11)18(24,19(20,21)22)17-27-12-6-10(7-23)8-26-16(12)28-17/h3-6,8,25H,24H2,1-2H3,(H,26,27,28)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 290n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Recombinant human factor B (expressed in drosophila cells and purified using standard methods) labeled with biotin (10 nM), europium-labeled streptav...


Citation and Details
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM251880
PNG
(US9475806, 11-B b) (-))
Show SMILES CNC(C)(c1nc2cc(cnc2[nH]1)C#N)c1c(OC)cc(C)c2[nH]ccc12
Show InChI InChI=1S/C20H20N6O/c1-11-7-15(27-4)16(13-5-6-23-17(11)13)20(2,22-3)19-25-14-8-12(9-21)10-24-18(14)26-19/h5-8,10,22-23H,1-4H3,(H,24,25,26)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 295n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Recombinant human factor B (expressed in drosophila cells and purified using standard methods) labeled with biotin (10 nM), europium-labeled streptav...


Citation and Details
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM251886
PNG
(US9475806, 16-G)
Show SMILES Cc1cc(C2CC2)c(C(O)c2nc3cc(cnc3[nH]2)C#N)c2cc[nH]c12
Show InChI InChI=1S/C20H17N5O/c1-10-6-14(12-2-3-12)16(13-4-5-22-17(10)13)18(26)20-24-15-7-11(8-21)9-23-19(15)25-20/h4-7,9,12,18,22,26H,2-3H2,1H3,(H,23,24,25)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 460n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Recombinant human factor B (expressed in drosophila cells and purified using standard methods) labeled with biotin (10 nM), europium-labeled streptav...


Citation and Details
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM251885
PNG
(US9475806, 15-D)
Show SMILES CCc1cc(C)c2[nH]ccc2c1C(C)(NC)c1nc2cc(cnc2[nH]1)C#N
Show InChI InChI=1S/C21H22N6/c1-5-14-8-12(2)18-15(6-7-24-18)17(14)21(3,23-4)20-26-16-9-13(10-22)11-25-19(16)27-20/h6-9,11,23-24H,5H2,1-4H3,(H,25,26,27)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 540n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Recombinant human factor B (expressed in drosophila cells and purified using standard methods) labeled with biotin (10 nM), europium-labeled streptav...


Citation and Details
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM251871
PNG
(US9475806, 6-C b) (+))
Show SMILES COc1cc(C)c2[nH]ccc2c1C(O)c1nc2ncc(cc2[nH]1)C#N
Show InChI InChI=1S/C18H15N5O2/c1-9-5-13(25-2)14(11-3-4-20-15(9)11)16(24)18-22-12-6-10(7-19)8-21-17(12)23-18/h3-6,8,16,20,24H,1-2H3,(H,21,22,23)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 700n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Recombinant human factor B (expressed in drosophila cells and purified using standard methods) labeled with biotin (10 nM), europium-labeled streptav...


Citation and Details
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM251875
PNG
(US9475806, 8-B b) (+))
Show SMILES COc1cc(C)c2[nH]ccc2c1C(C)(OC)c1nc2cc(cnc2[nH]1)C#N
Show InChI InChI=1S/C20H19N5O2/c1-11-7-15(26-3)16(13-5-6-22-17(11)13)20(2,27-4)19-24-14-8-12(9-21)10-23-18(14)25-19/h5-8,10,22H,1-4H3,(H,23,24,25)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 720n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Recombinant human factor B (expressed in drosophila cells and purified using standard methods) labeled with biotin (10 nM), europium-labeled streptav...


Citation and Details
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM251879
PNG
(US9475806, 10-B b) (+))
Show SMILES COc1cc(C)c2[nH]ccc2c1C(C)(N)c1nc2cc(cnc2[nH]1)C#N
Show InChI InChI=1S/C19H18N6O/c1-10-6-14(26-3)15(12-4-5-22-16(10)12)19(2,21)18-24-13-7-11(8-20)9-23-17(13)25-18/h4-7,9,22H,21H2,1-3H3,(H,23,24,25)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.38E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Recombinant human factor B (expressed in drosophila cells and purified using standard methods) labeled with biotin (10 nM), europium-labeled streptav...


Citation and Details
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM251877
PNG
(US9475806, 9-D b) (+))
Show SMILES CNC(c1nc2cc(cnc2[nH]1)C#N)(c1c(OC)cc(C)c2[nH]ccc12)C(F)(F)F
Show InChI InChI=1S/C20H17F3N6O/c1-10-6-14(30-3)15(12-4-5-26-16(10)12)19(25-2,20(21,22)23)18-28-13-7-11(8-24)9-27-17(13)29-18/h4-7,9,25-26H,1-3H3,(H,27,28,29)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.53E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Recombinant human factor B (expressed in drosophila cells and purified using standard methods) labeled with biotin (10 nM), europium-labeled streptav...


Citation and Details
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM251884
PNG
(US9475806, 14-I b) (+))
Show SMILES CCc1cc(C)c2[nH]ccc2c1C(O)(c1nc2cc(cnc2[nH]1)C#N)C(F)(F)F
Show InChI InChI=1S/C20H16F3N5O/c1-3-12-6-10(2)16-13(4-5-25-16)15(12)19(29,20(21,22)23)18-27-14-7-11(8-24)9-26-17(14)28-18/h4-7,9,25,29H,3H2,1-2H3,(H,26,27,28)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.35E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Recombinant human factor B (expressed in drosophila cells and purified using standard methods) labeled with biotin (10 nM), europium-labeled streptav...


Citation and Details
More data for this
Ligand-Target Pair
Complement factor B


(Homo sapiens (Human))
BDBM251881
PNG
(US9475806, 11-B b) (+))
Show SMILES CNC(C)(c1nc2cc(cnc2[nH]1)C#N)c1c(OC)cc(C)c2[nH]ccc12
Show InChI InChI=1S/C20H20N6O/c1-11-7-15(27-4)16(13-5-6-23-17(11)13)20(2,22-3)19-25-14-8-12(9-21)10-24-18(14)26-19/h5-8,10,22-23H,1-4H3,(H,24,25,26)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.14E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Recombinant human factor B (expressed in drosophila cells and purified using standard methods) labeled with biotin (10 nM), europium-labeled streptav...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%