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Patent code US9475815

Compile Data Set for Download or QSAR

Found 228 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
GST-Fibroblast growth factor receptor 1 (FGFR-1)


(Homo sapiens (Human))
BDBM255620
PNG
(US9475815, 5)
Show SMILES COc1cc(C)cc2cc(sc12)-c1cc(CN2CC[C@](C)(N)C2)n2ncnc(N)c12
Show InChI InChI=1S/C22H26N6OS/c1-13-6-14-8-18(30-20(14)17(7-13)29-3)16-9-15(10-27-5-4-22(2,24)11-27)28-19(16)21(23)25-12-26-28/h6-9,12H,4-5,10-11,24H2,1-3H3,(H2,23,25,26)/t22-/m0/s1
PDB

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US Patent
n/an/a 1.10n/an/an/an/an/an/a



BAYER INTELLETUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant tagged FGFR-1 fusion protein [fusion of glutathione-S-transferase (GST) (N-terminally), His6-tag, thrombin cleavage site, and the intra...


Citation and Details
More data for this
Ligand-Target Pair
GST-Fibroblast growth factor receptor 1 (FGFR-1)


(Homo sapiens (Human))
BDBM255701
PNG
(US9475815, 86)
Show SMILES COc1cc(C)cc2cc(sc12)-c1cc(CN2CCCC(C2)N(C)C)n2ncnc(N)c12
Show InChI InChI=1S/C24H30N6OS/c1-15-8-16-10-21(32-23(16)20(9-15)31-4)19-11-18(30-22(19)24(25)26-14-27-30)13-29-7-5-6-17(12-29)28(2)3/h8-11,14,17H,5-7,12-13H2,1-4H3,(H2,25,26,27)
PDB

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UniChem
US Patent
n/an/a 4.60n/an/an/an/an/an/a



BAYER INTELLETUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant tagged FGFR-1 fusion protein [fusion of glutathione-S-transferase (GST) (N-terminally), His6-tag, thrombin cleavage site, and the intra...


Citation and Details
More data for this
Ligand-Target Pair
GST-Fibroblast growth factor receptor 1 (FGFR-1)


(Homo sapiens (Human))
BDBM255712
PNG
(US9475815, 97)
Show SMILES COc1cc(C)cc2cc(sc12)-c1cc(C(=O)N2CC[C@](C)(N)C2)n2ncnc(N)c12
Show InChI InChI=1S/C22H24N6O2S/c1-12-6-13-8-17(31-19(13)16(7-12)30-3)14-9-15(28-18(14)20(23)25-11-26-28)21(29)27-5-4-22(2,24)10-27/h6-9,11H,4-5,10,24H2,1-3H3,(H2,23,25,26)/t22-/m0/s1
PDB

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US Patent
n/an/a 4.70n/an/an/an/an/an/a



BAYER INTELLETUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant tagged FGFR-1 fusion protein [fusion of glutathione-S-transferase (GST) (N-terminally), His6-tag, thrombin cleavage site, and the intra...


Citation and Details
More data for this
Ligand-Target Pair
GST-Fibroblast growth factor receptor 1 (FGFR-1)


(Homo sapiens (Human))
BDBM255624
PNG
(US9475815, 9)
Show SMILES COc1cc(C)cc2cc(sc12)-c1cc(CN2CC[C@H](N)C2)n2ncnc(N)c12
Show InChI InChI=1S/C21H24N6OS/c1-12-5-13-7-18(29-20(13)17(6-12)28-2)16-8-15(10-26-4-3-14(22)9-26)27-19(16)21(23)24-11-25-27/h5-8,11,14H,3-4,9-10,22H2,1-2H3,(H2,23,24,25)/t14-/m0/s1
PDB

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n/an/a 4.70n/an/an/an/an/an/a



BAYER INTELLETUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant tagged FGFR-1 fusion protein [fusion of glutathione-S-transferase (GST) (N-terminally), His6-tag, thrombin cleavage site, and the intra...


Citation and Details
More data for this
Ligand-Target Pair
GST-Fibroblast growth factor receptor 1 (FGFR-1)


(Homo sapiens (Human))
BDBM255656
PNG
(US9475815, 41)
Show SMILES CNC1CCN(Cc2cc(-c3cc4cc(C)cc(OC)c4s3)c3c(N)ncnn23)C1
Show InChI InChI=1S/C22H26N6OS/c1-13-6-14-8-19(30-21(14)18(7-13)29-3)17-9-16(11-27-5-4-15(10-27)24-2)28-20(17)22(23)25-12-26-28/h6-9,12,15,24H,4-5,10-11H2,1-3H3,(H2,23,25,26)
PDB

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US Patent
n/an/a 7.30n/an/an/an/an/an/a



BAYER INTELLETUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant tagged FGFR-1 fusion protein [fusion of glutathione-S-transferase (GST) (N-terminally), His6-tag, thrombin cleavage site, and the intra...


Citation and Details
More data for this
Ligand-Target Pair
GST-Fibroblast growth factor receptor 3 (FGFR-3)


(Homo sapiens (Human))
BDBM255624
PNG
(US9475815, 9)
Show SMILES COc1cc(C)cc2cc(sc12)-c1cc(CN2CC[C@H](N)C2)n2ncnc(N)c12
Show InChI InChI=1S/C21H24N6OS/c1-12-5-13-7-18(29-20(13)17(6-12)28-2)16-8-15(10-26-4-3-14(22)9-26)27-19(16)21(23)24-11-25-27/h5-8,11,14H,3-4,9-10,22H2,1-2H3,(H2,23,24,25)/t14-/m0/s1
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n/an/a 7.40n/an/an/an/an/an/a



BAYER INTELLETUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant tagged FGFR-3 fusion protein [fusion of glutathione-S-transferase (GST) (N-terminally), His6-tag, thrombin cleavage site, and the intra...


Citation and Details
More data for this
Ligand-Target Pair
GST-Fibroblast growth factor receptor 3 (FGFR-3)


(Homo sapiens (Human))
BDBM255620
PNG
(US9475815, 5)
Show SMILES COc1cc(C)cc2cc(sc12)-c1cc(CN2CC[C@](C)(N)C2)n2ncnc(N)c12
Show InChI InChI=1S/C22H26N6OS/c1-13-6-14-8-18(30-20(14)17(7-13)29-3)16-9-15(10-27-5-4-22(2,24)11-27)28-19(16)21(23)25-12-26-28/h6-9,12H,4-5,10-11,24H2,1-3H3,(H2,23,25,26)/t22-/m0/s1
PDB

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n/an/a 7.40n/an/an/an/an/an/a



BAYER INTELLETUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant tagged FGFR-3 fusion protein [fusion of glutathione-S-transferase (GST) (N-terminally), His6-tag, thrombin cleavage site, and the intra...


Citation and Details
More data for this
Ligand-Target Pair
GST-Fibroblast growth factor receptor 1 (FGFR-1)


(Homo sapiens (Human))
BDBM255622
PNG
(US9475815, 7)
Show SMILES COc1cc(C)cc2cc(sc12)-c1cc(CN2CCNC(C2)C(N)=O)n2ncnc(N)c12
Show InChI InChI=1S/C22H25N7O2S/c1-12-5-13-7-18(32-20(13)17(6-12)31-2)15-8-14(29-19(15)21(23)26-11-27-29)9-28-4-3-25-16(10-28)22(24)30/h5-8,11,16,25H,3-4,9-10H2,1-2H3,(H2,24,30)(H2,23,26,27)
PDB

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n/an/a 7.80n/an/an/an/an/an/a



BAYER INTELLETUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant tagged FGFR-1 fusion protein [fusion of glutathione-S-transferase (GST) (N-terminally), His6-tag, thrombin cleavage site, and the intra...


Citation and Details
More data for this
Ligand-Target Pair
GST-Fibroblast growth factor receptor 3 (FGFR-3)


(Homo sapiens (Human))
BDBM255633
PNG
(US9475815, 18)
Show SMILES COc1cc(C)cc2cc(sc12)-c1cc(CNCC(N)=O)n2ncnc(N)c12
Show InChI InChI=1S/C19H20N6O2S/c1-10-3-11-5-15(28-18(11)14(4-10)27-2)13-6-12(7-22-8-16(20)26)25-17(13)19(21)23-9-24-25/h3-6,9,22H,7-8H2,1-2H3,(H2,20,26)(H2,21,23,24)
PDB

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n/an/a 7.80n/an/an/an/an/an/a



BAYER INTELLETUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant tagged FGFR-3 fusion protein [fusion of glutathione-S-transferase (GST) (N-terminally), His6-tag, thrombin cleavage site, and the intra...


Citation and Details
More data for this
Ligand-Target Pair
GST-Fibroblast growth factor receptor 1 (FGFR-1)


(Homo sapiens (Human))
BDBM255669
PNG
(US9475815, 54)
Show SMILES COc1cc(C)cc2cc(sc12)-c1cc(CN2CCN[C@](C)(N)C2)n2ncnc(N)c12
Show InChI InChI=1S/C22H27N7OS/c1-13-6-14-8-18(31-20(14)17(7-13)30-3)16-9-15(29-19(16)21(23)25-12-27-29)10-28-5-4-26-22(2,24)11-28/h6-9,12,26H,4-5,10-11,24H2,1-3H3,(H2,23,25,27)/t22-/m0/s1
PDB

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n/an/a 7.90n/an/an/an/an/an/a



BAYER INTELLETUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant tagged FGFR-1 fusion protein [fusion of glutathione-S-transferase (GST) (N-terminally), His6-tag, thrombin cleavage site, and the intra...


Citation and Details
More data for this
Ligand-Target Pair
GST-Fibroblast growth factor receptor 3 (FGFR-3)


(Homo sapiens (Human))
BDBM255636
PNG
(US9475815, 21)
Show SMILES COc1cc(C)cc2cc(sc12)-c1cc(CN2CC(O)C(C2)NCCO)n2ncnc(N)c12
Show InChI InChI=1S/C23H28N6O3S/c1-13-5-14-7-20(33-22(14)19(6-13)32-2)16-8-15(29-21(16)23(24)26-12-27-29)9-28-10-17(18(31)11-28)25-3-4-30/h5-8,12,17-18,25,30-31H,3-4,9-11H2,1-2H3,(H2,24,26,27)
PDB

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n/an/a 8n/an/an/an/an/an/a



BAYER INTELLETUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant tagged FGFR-3 fusion protein [fusion of glutathione-S-transferase (GST) (N-terminally), His6-tag, thrombin cleavage site, and the intra...


Citation and Details
More data for this
Ligand-Target Pair
GST-Fibroblast growth factor receptor 1 (FGFR-1)


(Homo sapiens (Human))
BDBM255713
PNG
(US9475815, 98)
Show SMILES COc1cc(C)cc2cc(sc12)-c1cc(C(=O)NC2CCNC2=O)n2ncnc(N)c12
Show InChI InChI=1S/C21H20N6O3S/c1-10-5-11-7-16(31-18(11)15(6-10)30-2)12-8-14(27-17(12)19(22)24-9-25-27)21(29)26-13-3-4-23-20(13)28/h5-9,13H,3-4H2,1-2H3,(H,23,28)(H,26,29)(H2,22,24,25)
PDB

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n/an/a 9n/an/an/an/an/an/a



BAYER INTELLETUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant tagged FGFR-1 fusion protein [fusion of glutathione-S-transferase (GST) (N-terminally), His6-tag, thrombin cleavage site, and the intra...


Citation and Details
More data for this
Ligand-Target Pair
GST-Fibroblast growth factor receptor 1 (FGFR-1)


(Homo sapiens (Human))
BDBM255637
PNG
(US9475815, 22)
Show SMILES COc1cc(C)cc2cc(sc12)-c1cc(CN2CCC(C2)NCC(C)O)n2ncnc(N)c12
Show InChI InChI=1S/C24H30N6O2S/c1-14-6-16-8-21(33-23(16)20(7-14)32-3)19-9-18(30-22(19)24(25)27-13-28-30)12-29-5-4-17(11-29)26-10-15(2)31/h6-9,13,15,17,26,31H,4-5,10-12H2,1-3H3,(H2,25,27,28)
PDB

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n/an/a 9.30n/an/an/an/an/an/a



BAYER INTELLETUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant tagged FGFR-1 fusion protein [fusion of glutathione-S-transferase (GST) (N-terminally), His6-tag, thrombin cleavage site, and the intra...


Citation and Details
More data for this
Ligand-Target Pair
GST-Fibroblast growth factor receptor 3 (FGFR-3)


(Homo sapiens (Human))
BDBM255701
PNG
(US9475815, 86)
Show SMILES COc1cc(C)cc2cc(sc12)-c1cc(CN2CCCC(C2)N(C)C)n2ncnc(N)c12
Show InChI InChI=1S/C24H30N6OS/c1-15-8-16-10-21(32-23(16)20(9-15)31-4)19-11-18(30-22(19)24(25)26-14-27-30)13-29-7-5-6-17(12-29)28(2)3/h8-11,14,17H,5-7,12-13H2,1-4H3,(H2,25,26,27)
PDB

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n/an/a 9.60n/an/an/an/an/an/a



BAYER INTELLETUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant tagged FGFR-3 fusion protein [fusion of glutathione-S-transferase (GST) (N-terminally), His6-tag, thrombin cleavage site, and the intra...


Citation and Details
More data for this
Ligand-Target Pair
GST-Fibroblast growth factor receptor 3 (FGFR-3)


(Homo sapiens (Human))
BDBM255712
PNG
(US9475815, 97)
Show SMILES COc1cc(C)cc2cc(sc12)-c1cc(C(=O)N2CC[C@](C)(N)C2)n2ncnc(N)c12
Show InChI InChI=1S/C22H24N6O2S/c1-12-6-13-8-17(31-19(13)16(7-12)30-3)14-9-15(28-18(14)20(23)25-11-26-28)21(29)27-5-4-22(2,24)10-27/h6-9,11H,4-5,10,24H2,1-3H3,(H2,23,25,26)/t22-/m0/s1
PDB

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n/an/a 9.90n/an/an/an/an/an/a



BAYER INTELLETUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant tagged FGFR-3 fusion protein [fusion of glutathione-S-transferase (GST) (N-terminally), His6-tag, thrombin cleavage site, and the intra...


Citation and Details
More data for this
Ligand-Target Pair
GST-Fibroblast growth factor receptor 1 (FGFR-1)


(Homo sapiens (Human))
BDBM255616
PNG
(BDBM255617 | US9475815, 1)
Show SMILES COc1cc(C)cc2cc(sc12)-c1cc(CN2CCNCC2)n2ncnc(N)c12
Show InChI InChI=1S/C21H24N6OS/c1-13-7-14-9-18(29-20(14)17(8-13)28-2)16-10-15(11-26-5-3-23-4-6-26)27-19(16)21(22)24-12-25-27/h7-10,12,23H,3-6,11H2,1-2H3,(H2,22,24,25)
PDB

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n/an/a 9.90n/an/an/an/an/an/a



BAYER INTELLETUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant tagged FGFR-1 fusion protein [fusion of glutathione-S-transferase (GST) (N-terminally), His6-tag, thrombin cleavage site, and the intra...


Citation and Details
More data for this
Ligand-Target Pair
GST-Fibroblast growth factor receptor 1 (FGFR-1)


(Homo sapiens (Human))
BDBM255630
PNG
(US9475815, 15)
Show SMILES COc1cc(C)cc2cc(sc12)-c1cc(CN2CC[C@@H](C2)N(C)C)n2ncnc(N)c12
Show InChI InChI=1S/C23H28N6OS/c1-14-7-15-9-20(31-22(15)19(8-14)30-4)18-10-17(29-21(18)23(24)25-13-26-29)12-28-6-5-16(11-28)27(2)3/h7-10,13,16H,5-6,11-12H2,1-4H3,(H2,24,25,26)/t16-/m0/s1
PDB

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n/an/a 11.1n/an/an/an/an/an/a



BAYER INTELLETUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant tagged FGFR-1 fusion protein [fusion of glutathione-S-transferase (GST) (N-terminally), His6-tag, thrombin cleavage site, and the intra...


Citation and Details
More data for this
Ligand-Target Pair
GST-Fibroblast growth factor receptor 3 (FGFR-3)


(Homo sapiens (Human))
BDBM255707
PNG
(US9475815, 92)
Show SMILES COc1cc(C)cc2cc(sc12)-c1cc(CN[C@@H](CC(N)=O)C(O)=O)n2ncnc(N)c12
Show InChI InChI=1S/C21H22N6O4S/c1-10-3-11-5-16(32-19(11)15(4-10)31-2)13-6-12(27-18(13)20(23)25-9-26-27)8-24-14(21(29)30)7-17(22)28/h3-6,9,14,24H,7-8H2,1-2H3,(H2,22,28)(H,29,30)(H2,23,25,26)/t14-/m0/s1
PDB

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n/an/a 11.7n/an/an/an/an/an/a



BAYER INTELLETUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant tagged FGFR-3 fusion protein [fusion of glutathione-S-transferase (GST) (N-terminally), His6-tag, thrombin cleavage site, and the intra...


Citation and Details
More data for this
Ligand-Target Pair
GST-Fibroblast growth factor receptor 3 (FGFR-3)


(Homo sapiens (Human))
BDBM255711
PNG
(US9475815, 96)
Show SMILES COc1cc(C)cc2cc(sc12)-c1cc(CN2CCN(CC2)C(=O)CO)n2ncnc(N)c12
Show InChI InChI=1S/C23H26N6O3S/c1-14-7-15-9-19(33-22(15)18(8-14)32-2)17-10-16(29-21(17)23(24)25-13-26-29)11-27-3-5-28(6-4-27)20(31)12-30/h7-10,13,30H,3-6,11-12H2,1-2H3,(H2,24,25,26)
PDB

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US Patent
n/an/a 11.9n/an/an/an/an/an/a



BAYER INTELLETUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant tagged FGFR-3 fusion protein [fusion of glutathione-S-transferase (GST) (N-terminally), His6-tag, thrombin cleavage site, and the intra...


Citation and Details
More data for this
Ligand-Target Pair
GST-Fibroblast growth factor receptor 1 (FGFR-1)


(Homo sapiens (Human))
BDBM255711
PNG
(US9475815, 96)
Show SMILES COc1cc(C)cc2cc(sc12)-c1cc(CN2CCN(CC2)C(=O)CO)n2ncnc(N)c12
Show InChI InChI=1S/C23H26N6O3S/c1-14-7-15-9-19(33-22(15)18(8-14)32-2)17-10-16(29-21(17)23(24)25-13-26-29)11-27-3-5-28(6-4-27)20(31)12-30/h7-10,13,30H,3-6,11-12H2,1-2H3,(H2,24,25,26)
PDB

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US Patent
n/an/a 12.6n/an/an/an/an/an/a



BAYER INTELLETUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant tagged FGFR-1 fusion protein [fusion of glutathione-S-transferase (GST) (N-terminally), His6-tag, thrombin cleavage site, and the intra...


Citation and Details
More data for this
Ligand-Target Pair
GST-Fibroblast growth factor receptor 3 (FGFR-3)


(Homo sapiens (Human))
BDBM255713
PNG
(US9475815, 98)
Show SMILES COc1cc(C)cc2cc(sc12)-c1cc(C(=O)NC2CCNC2=O)n2ncnc(N)c12
Show InChI InChI=1S/C21H20N6O3S/c1-10-5-11-7-16(31-18(11)15(6-10)30-2)12-8-14(27-17(12)19(22)24-9-25-27)21(29)26-13-3-4-23-20(13)28/h5-9,13H,3-4H2,1-2H3,(H,23,28)(H,26,29)(H2,22,24,25)
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n/an/a 13.1n/an/an/an/an/an/a



BAYER INTELLETUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant tagged FGFR-3 fusion protein [fusion of glutathione-S-transferase (GST) (N-terminally), His6-tag, thrombin cleavage site, and the intra...


Citation and Details
More data for this
Ligand-Target Pair
GST-Fibroblast growth factor receptor 1 (FGFR-1)


(Homo sapiens (Human))
BDBM255636
PNG
(US9475815, 21)
Show SMILES COc1cc(C)cc2cc(sc12)-c1cc(CN2CC(O)C(C2)NCCO)n2ncnc(N)c12
Show InChI InChI=1S/C23H28N6O3S/c1-13-5-14-7-20(33-22(14)19(6-13)32-2)16-8-15(29-21(16)23(24)26-12-27-29)9-28-10-17(18(31)11-28)25-3-4-30/h5-8,12,17-18,25,30-31H,3-4,9-11H2,1-2H3,(H2,24,26,27)
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BAYER INTELLETUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant tagged FGFR-1 fusion protein [fusion of glutathione-S-transferase (GST) (N-terminally), His6-tag, thrombin cleavage site, and the intra...


Citation and Details
More data for this
Ligand-Target Pair
GST-Fibroblast growth factor receptor 1 (FGFR-1)


(Homo sapiens (Human))
BDBM255702
PNG
(US9475815, 87)
Show SMILES COc1cc(C)cc2cc(sc12)-c1cc(CN[C@H]2CC[C@H](CC2)N(C)C)n2ncnc(N)c12
Show InChI InChI=1S/C25H32N6OS/c1-15-9-16-11-22(33-24(16)21(10-15)32-4)20-12-19(31-23(20)25(26)28-14-29-31)13-27-17-5-7-18(8-6-17)30(2)3/h9-12,14,17-18,27H,5-8,13H2,1-4H3,(H2,26,28,29)/t17-,18+
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BAYER INTELLETUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant tagged FGFR-1 fusion protein [fusion of glutathione-S-transferase (GST) (N-terminally), His6-tag, thrombin cleavage site, and the intra...


Citation and Details
More data for this
Ligand-Target Pair
GST-Fibroblast growth factor receptor 1 (FGFR-1)


(Homo sapiens (Human))
BDBM255657
PNG
(US9475815, 42)
Show SMILES COc1cc(C)cc2cc(sc12)-c1cc(CN2CCC(C2)N(C)C)n2ncnc(N)c12
Show InChI InChI=1S/C23H28N6OS/c1-14-7-15-9-20(31-22(15)19(8-14)30-4)18-10-17(29-21(18)23(24)25-13-26-29)12-28-6-5-16(11-28)27(2)3/h7-10,13,16H,5-6,11-12H2,1-4H3,(H2,24,25,26)
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BAYER INTELLETUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant tagged FGFR-1 fusion protein [fusion of glutathione-S-transferase (GST) (N-terminally), His6-tag, thrombin cleavage site, and the intra...


Citation and Details
More data for this
Ligand-Target Pair
GST-Fibroblast growth factor receptor 3 (FGFR-3)


(Homo sapiens (Human))
BDBM255719
PNG
(US9475815, 104)
Show SMILES COc1cc(C)cc2cc(sc12)-c1cc(C(=O)N2CCC[C@@H](N)C2)n2ncnc(N)c12
Show InChI InChI=1S/C22H24N6O2S/c1-12-6-13-8-18(31-20(13)17(7-12)30-2)15-9-16(28-19(15)21(24)25-11-26-28)22(29)27-5-3-4-14(23)10-27/h6-9,11,14H,3-5,10,23H2,1-2H3,(H2,24,25,26)/t14-/m1/s1
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BAYER INTELLETUAL PROPERTY GMBH

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Assay Description
A recombinant tagged FGFR-3 fusion protein [fusion of glutathione-S-transferase (GST) (N-terminally), His6-tag, thrombin cleavage site, and the intra...


Citation and Details
More data for this
Ligand-Target Pair
GST-Fibroblast growth factor receptor 1 (FGFR-1)


(Homo sapiens (Human))
BDBM255634
PNG
(US9475815, 19)
Show SMILES CCN(CC)C1CCN(Cc2cc(-c3cc4cc(C)cc(OC)c4s3)c3c(N)ncnn23)C1
Show InChI InChI=1S/C25H32N6OS/c1-5-30(6-2)18-7-8-29(13-18)14-19-12-20(23-25(26)27-15-28-31(19)23)22-11-17-9-16(3)10-21(32-4)24(17)33-22/h9-12,15,18H,5-8,13-14H2,1-4H3,(H2,26,27,28)
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BAYER INTELLETUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant tagged FGFR-1 fusion protein [fusion of glutathione-S-transferase (GST) (N-terminally), His6-tag, thrombin cleavage site, and the intra...


Citation and Details
More data for this
Ligand-Target Pair
GST-Fibroblast growth factor receptor 3 (FGFR-3)


(Homo sapiens (Human))
BDBM255631
PNG
(US9475815, 16)
Show SMILES CCN[C@H]1CCN(Cc2cc(-c3cc4cc(C)cc(OC)c4s3)c3c(N)ncnn23)C1
Show InChI InChI=1S/C23H28N6OS/c1-4-25-16-5-6-28(11-16)12-17-10-18(21-23(24)26-13-27-29(17)21)20-9-15-7-14(2)8-19(30-3)22(15)31-20/h7-10,13,16,25H,4-6,11-12H2,1-3H3,(H2,24,26,27)/t16-/m0/s1
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BAYER INTELLETUAL PROPERTY GMBH

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Assay Description
A recombinant tagged FGFR-3 fusion protein [fusion of glutathione-S-transferase (GST) (N-terminally), His6-tag, thrombin cleavage site, and the intra...


Citation and Details
More data for this
Ligand-Target Pair
GST-Fibroblast growth factor receptor 1 (FGFR-1)


(Homo sapiens (Human))
BDBM255631
PNG
(US9475815, 16)
Show SMILES CCN[C@H]1CCN(Cc2cc(-c3cc4cc(C)cc(OC)c4s3)c3c(N)ncnn23)C1
Show InChI InChI=1S/C23H28N6OS/c1-4-25-16-5-6-28(11-16)12-17-10-18(21-23(24)26-13-27-29(17)21)20-9-15-7-14(2)8-19(30-3)22(15)31-20/h7-10,13,16,25H,4-6,11-12H2,1-3H3,(H2,24,26,27)/t16-/m0/s1
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BAYER INTELLETUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant tagged FGFR-1 fusion protein [fusion of glutathione-S-transferase (GST) (N-terminally), His6-tag, thrombin cleavage site, and the intra...


Citation and Details
More data for this
Ligand-Target Pair
GST-Fibroblast growth factor receptor 1 (FGFR-1)


(Homo sapiens (Human))
BDBM255703
PNG
(US9475815, 88)
Show SMILES COc1cc(C)cc2cc(sc12)-c1cc(CN2CCC(O)CC2)n2ncnc(N)c12
Show InChI InChI=1S/C22H25N5O2S/c1-13-7-14-9-19(30-21(14)18(8-13)29-2)17-10-15(11-26-5-3-16(28)4-6-26)27-20(17)22(23)24-12-25-27/h7-10,12,16,28H,3-6,11H2,1-2H3,(H2,23,24,25)
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BAYER INTELLETUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant tagged FGFR-1 fusion protein [fusion of glutathione-S-transferase (GST) (N-terminally), His6-tag, thrombin cleavage site, and the intra...


Citation and Details
More data for this
Ligand-Target Pair
GST-Fibroblast growth factor receptor 3 (FGFR-3)


(Homo sapiens (Human))
BDBM255669
PNG
(US9475815, 54)
Show SMILES COc1cc(C)cc2cc(sc12)-c1cc(CN2CCN[C@](C)(N)C2)n2ncnc(N)c12
Show InChI InChI=1S/C22H27N7OS/c1-13-6-14-8-18(31-20(14)17(7-13)30-3)16-9-15(29-19(16)21(23)25-12-27-29)10-28-5-4-26-22(2,24)11-28/h6-9,12,26H,4-5,10-11,24H2,1-3H3,(H2,23,25,27)/t22-/m0/s1
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BAYER INTELLETUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant tagged FGFR-3 fusion protein [fusion of glutathione-S-transferase (GST) (N-terminally), His6-tag, thrombin cleavage site, and the intra...


Citation and Details
More data for this
Ligand-Target Pair
GST-Fibroblast growth factor receptor 1 (FGFR-1)


(Homo sapiens (Human))
BDBM255670
PNG
(US9475815, 55)
Show SMILES COc1cc(C)cc2cc(sc12)-c1cc(CN2CCC[C@@H](N)C2)n2ncnc(N)c12
Show InChI InChI=1S/C22H26N6OS/c1-13-6-14-8-19(30-21(14)18(7-13)29-2)17-9-16(11-27-5-3-4-15(23)10-27)28-20(17)22(24)25-12-26-28/h6-9,12,15H,3-5,10-11,23H2,1-2H3,(H2,24,25,26)/t15-/m1/s1
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BAYER INTELLETUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant tagged FGFR-1 fusion protein [fusion of glutathione-S-transferase (GST) (N-terminally), His6-tag, thrombin cleavage site, and the intra...


Citation and Details
More data for this
Ligand-Target Pair
GST-Fibroblast growth factor receptor 1 (FGFR-1)


(Homo sapiens (Human))
BDBM255650
PNG
(US9475815, 35)
Show SMILES COc1cc(C)cc2cc(sc12)-c1cc(CN2CCNC(C2)c2cccs2)n2ncnc(N)c12
Show InChI InChI=1S/C25H26N6OS2/c1-15-8-16-10-22(34-24(16)20(9-15)32-2)18-11-17(31-23(18)25(26)28-14-29-31)12-30-6-5-27-19(13-30)21-4-3-7-33-21/h3-4,7-11,14,19,27H,5-6,12-13H2,1-2H3,(H2,26,28,29)
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BAYER INTELLETUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant tagged FGFR-1 fusion protein [fusion of glutathione-S-transferase (GST) (N-terminally), His6-tag, thrombin cleavage site, and the intra...


Citation and Details
More data for this
Ligand-Target Pair
GST-Fibroblast growth factor receptor 1 (FGFR-1)


(Homo sapiens (Human))
BDBM255651
PNG
(US9475815, 36)
Show SMILES CCC1CN(Cc2cc(-c3cc4cc(C)cc(OC)c4s3)c3c(N)ncnn23)CCN1
Show InChI InChI=1S/C23H28N6OS/c1-4-16-11-28(6-5-25-16)12-17-10-18(21-23(24)26-13-27-29(17)21)20-9-15-7-14(2)8-19(30-3)22(15)31-20/h7-10,13,16,25H,4-6,11-12H2,1-3H3,(H2,24,26,27)
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BAYER INTELLETUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant tagged FGFR-1 fusion protein [fusion of glutathione-S-transferase (GST) (N-terminally), His6-tag, thrombin cleavage site, and the intra...


Citation and Details
More data for this
Ligand-Target Pair
GST-Fibroblast growth factor receptor 1 (FGFR-1)


(Homo sapiens (Human))
BDBM255671
PNG
(US9475815, 56)
Show SMILES COc1cc(C)cc2cc(sc12)-c1cc(CN2CCC[C@H](N)C2)n2ncnc(N)c12
Show InChI InChI=1S/C22H26N6OS/c1-13-6-14-8-19(30-21(14)18(7-13)29-2)17-9-16(11-27-5-3-4-15(23)10-27)28-20(17)22(24)25-12-26-28/h6-9,12,15H,3-5,10-11,23H2,1-2H3,(H2,24,25,26)/t15-/m0/s1
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BAYER INTELLETUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant tagged FGFR-1 fusion protein [fusion of glutathione-S-transferase (GST) (N-terminally), His6-tag, thrombin cleavage site, and the intra...


Citation and Details
More data for this
Ligand-Target Pair
GST-Fibroblast growth factor receptor 1 (FGFR-1)


(Homo sapiens (Human))
BDBM255660
PNG
(US9475815, 45)
Show SMILES COc1cc(C)cc2cc(sc12)-c1cc(CN2CCNC(C)(C)C2)n2ncnc(N)c12
Show InChI InChI=1S/C23H28N6OS/c1-14-7-15-9-19(31-21(15)18(8-14)30-4)17-10-16(29-20(17)22(24)25-13-27-29)11-28-6-5-26-23(2,3)12-28/h7-10,13,26H,5-6,11-12H2,1-4H3,(H2,24,25,27)
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BAYER INTELLETUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant tagged FGFR-1 fusion protein [fusion of glutathione-S-transferase (GST) (N-terminally), His6-tag, thrombin cleavage site, and the intra...


Citation and Details
More data for this
Ligand-Target Pair
GST-Fibroblast growth factor receptor 3 (FGFR-3)


(Homo sapiens (Human))
BDBM255670
PNG
(US9475815, 55)
Show SMILES COc1cc(C)cc2cc(sc12)-c1cc(CN2CCC[C@@H](N)C2)n2ncnc(N)c12
Show InChI InChI=1S/C22H26N6OS/c1-13-6-14-8-19(30-21(14)18(7-13)29-2)17-9-16(11-27-5-3-4-15(23)10-27)28-20(17)22(24)25-12-26-28/h6-9,12,15H,3-5,10-11,23H2,1-2H3,(H2,24,25,26)/t15-/m1/s1
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BAYER INTELLETUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant tagged FGFR-3 fusion protein [fusion of glutathione-S-transferase (GST) (N-terminally), His6-tag, thrombin cleavage site, and the intra...


Citation and Details
More data for this
Ligand-Target Pair
GST-Fibroblast growth factor receptor 1 (FGFR-1)


(Homo sapiens (Human))
BDBM255638
PNG
(US9475815, 23)
Show SMILES COc1cc(C)cc2cc(sc12)-c1cc(CN2CC3CNCC3C2)n2ncnc(N)c12
Show InChI InChI=1S/C23H26N6OS/c1-13-3-14-5-20(31-22(14)19(4-13)30-2)18-6-17(29-21(18)23(24)26-12-27-29)11-28-9-15-7-25-8-16(15)10-28/h3-6,12,15-16,25H,7-11H2,1-2H3,(H2,24,26,27)
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BAYER INTELLETUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant tagged FGFR-1 fusion protein [fusion of glutathione-S-transferase (GST) (N-terminally), His6-tag, thrombin cleavage site, and the intra...


Citation and Details
More data for this
Ligand-Target Pair
GST-Fibroblast growth factor receptor 1 (FGFR-1)


(Homo sapiens (Human))
BDBM255616
PNG
(BDBM255617 | US9475815, 1)
Show SMILES COc1cc(C)cc2cc(sc12)-c1cc(CN2CCNCC2)n2ncnc(N)c12
Show InChI InChI=1S/C21H24N6OS/c1-13-7-14-9-18(29-20(14)17(8-13)28-2)16-10-15(11-26-5-3-23-4-6-26)27-19(16)21(22)24-12-25-27/h7-10,12,23H,3-6,11H2,1-2H3,(H2,22,24,25)
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BAYER INTELLETUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant tagged FGFR-1 fusion protein [fusion of glutathione-S-transferase (GST) (N-terminally), His6-tag, thrombin cleavage site, and the intra...


Citation and Details
More data for this
Ligand-Target Pair
GST-Fibroblast growth factor receptor 1 (FGFR-1)


(Homo sapiens (Human))
BDBM255621
PNG
(US9475815, 6)
Show SMILES COc1cc(C)cc2cc(sc12)-c1cc(CN[C@@H]2CCNC2=O)n2ncnc(N)c12
Show InChI InChI=1S/C21H22N6O2S/c1-11-5-12-7-17(30-19(12)16(6-11)29-2)14-8-13(9-24-15-3-4-23-21(15)28)27-18(14)20(22)25-10-26-27/h5-8,10,15,24H,3-4,9H2,1-2H3,(H,23,28)(H2,22,25,26)/t15-/m1/s1
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BAYER INTELLETUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant tagged FGFR-1 fusion protein [fusion of glutathione-S-transferase (GST) (N-terminally), His6-tag, thrombin cleavage site, and the intra...


Citation and Details
More data for this
Ligand-Target Pair
GST-Fibroblast growth factor receptor 1 (FGFR-1)


(Homo sapiens (Human))
BDBM255720
PNG
(US9475815, 105)
Show SMILES COc1cc(C)cc2cc(sc12)-c1cc(C(=O)N2CCC[C@](C)(N)C2)n2ncnc(N)c12
Show InChI InChI=1S/C23H26N6O2S/c1-13-7-14-9-18(32-20(14)17(8-13)31-3)15-10-16(29-19(15)21(24)26-12-27-29)22(30)28-6-4-5-23(2,25)11-28/h7-10,12H,4-6,11,25H2,1-3H3,(H2,24,26,27)/t23-/m0/s1
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BAYER INTELLETUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant tagged FGFR-1 fusion protein [fusion of glutathione-S-transferase (GST) (N-terminally), His6-tag, thrombin cleavage site, and the intra...


Citation and Details
More data for this
Ligand-Target Pair
GST-Fibroblast growth factor receptor 1 (FGFR-1)


(Homo sapiens (Human))
BDBM255715
PNG
(US9475815, 100)
Show SMILES COc1cc(C)cc2cc(sc12)-c1cc(C(=O)N2CCC(C2)N(C)C)n2ncnc(N)c12
Show InChI InChI=1S/C23H26N6O2S/c1-13-7-14-9-19(32-21(14)18(8-13)31-4)16-10-17(29-20(16)22(24)25-12-26-29)23(30)28-6-5-15(11-28)27(2)3/h7-10,12,15H,5-6,11H2,1-4H3,(H2,24,25,26)
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n/an/a 20.7n/an/an/an/an/an/a



BAYER INTELLETUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant tagged FGFR-1 fusion protein [fusion of glutathione-S-transferase (GST) (N-terminally), His6-tag, thrombin cleavage site, and the intra...


Citation and Details
More data for this
Ligand-Target Pair
GST-Fibroblast growth factor receptor 1 (FGFR-1)


(Homo sapiens (Human))
BDBM255661
PNG
(US9475815, 46)
Show SMILES COc1cc(C)cc2cc(sc12)-c1cc(CN(C)C2CCN(C)C2)n2ncnc(N)c12
Show InChI InChI=1S/C23H28N6OS/c1-14-7-15-9-20(31-22(15)19(8-14)30-4)18-10-17(29-21(18)23(24)25-13-26-29)12-28(3)16-5-6-27(2)11-16/h7-10,13,16H,5-6,11-12H2,1-4H3,(H2,24,25,26)
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n/an/a 20.8n/an/an/an/an/an/a



BAYER INTELLETUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant tagged FGFR-1 fusion protein [fusion of glutathione-S-transferase (GST) (N-terminally), His6-tag, thrombin cleavage site, and the intra...


Citation and Details
More data for this
Ligand-Target Pair
GST-Fibroblast growth factor receptor 3 (FGFR-3)


(Homo sapiens (Human))
BDBM255703
PNG
(US9475815, 88)
Show SMILES COc1cc(C)cc2cc(sc12)-c1cc(CN2CCC(O)CC2)n2ncnc(N)c12
Show InChI InChI=1S/C22H25N5O2S/c1-13-7-14-9-19(30-21(14)18(8-13)29-2)17-10-15(11-26-5-3-16(28)4-6-26)27-20(17)22(23)24-12-25-27/h7-10,12,16,28H,3-6,11H2,1-2H3,(H2,23,24,25)
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n/an/a 21.3n/an/an/an/an/an/a



BAYER INTELLETUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant tagged FGFR-3 fusion protein [fusion of glutathione-S-transferase (GST) (N-terminally), His6-tag, thrombin cleavage site, and the intra...


Citation and Details
More data for this
Ligand-Target Pair
GST-Fibroblast growth factor receptor 3 (FGFR-3)


(Homo sapiens (Human))
BDBM255621
PNG
(US9475815, 6)
Show SMILES COc1cc(C)cc2cc(sc12)-c1cc(CN[C@@H]2CCNC2=O)n2ncnc(N)c12
Show InChI InChI=1S/C21H22N6O2S/c1-11-5-12-7-17(30-19(12)16(6-11)29-2)14-8-13(9-24-15-3-4-23-21(15)28)27-18(14)20(22)25-10-26-27/h5-8,10,15,24H,3-4,9H2,1-2H3,(H,23,28)(H2,22,25,26)/t15-/m1/s1
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n/an/a 21.7n/an/an/an/an/an/a



BAYER INTELLETUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant tagged FGFR-3 fusion protein [fusion of glutathione-S-transferase (GST) (N-terminally), His6-tag, thrombin cleavage site, and the intra...


Citation and Details
More data for this
Ligand-Target Pair
GST-Fibroblast growth factor receptor 3 (FGFR-3)


(Homo sapiens (Human))
BDBM255700
PNG
(US9475815, 85)
Show SMILES COc1cc(C)cc2cc(sc12)-c1cc(CN[C@@H](C)C(N)=O)n2ncnc(N)c12
Show InChI InChI=1S/C20H22N6O2S/c1-10-4-12-6-16(29-18(12)15(5-10)28-3)14-7-13(8-23-11(2)20(22)27)26-17(14)19(21)24-9-25-26/h4-7,9,11,23H,8H2,1-3H3,(H2,22,27)(H2,21,24,25)/t11-/m0/s1
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n/an/a 22.1n/an/an/an/an/an/a



BAYER INTELLETUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant tagged FGFR-3 fusion protein [fusion of glutathione-S-transferase (GST) (N-terminally), His6-tag, thrombin cleavage site, and the intra...


Citation and Details
More data for this
Ligand-Target Pair
GST-Fibroblast growth factor receptor 3 (FGFR-3)


(Homo sapiens (Human))
BDBM255671
PNG
(US9475815, 56)
Show SMILES COc1cc(C)cc2cc(sc12)-c1cc(CN2CCC[C@H](N)C2)n2ncnc(N)c12
Show InChI InChI=1S/C22H26N6OS/c1-13-6-14-8-19(30-21(14)18(7-13)29-2)17-9-16(11-27-5-3-4-15(23)10-27)28-20(17)22(24)25-12-26-28/h6-9,12,15H,3-5,10-11,23H2,1-2H3,(H2,24,25,26)/t15-/m0/s1
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n/an/a 22.6n/an/an/an/an/an/a



BAYER INTELLETUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant tagged FGFR-3 fusion protein [fusion of glutathione-S-transferase (GST) (N-terminally), His6-tag, thrombin cleavage site, and the intra...


Citation and Details
More data for this
Ligand-Target Pair
GST-Fibroblast growth factor receptor 3 (FGFR-3)


(Homo sapiens (Human))
BDBM255630
PNG
(US9475815, 15)
Show SMILES COc1cc(C)cc2cc(sc12)-c1cc(CN2CC[C@@H](C2)N(C)C)n2ncnc(N)c12
Show InChI InChI=1S/C23H28N6OS/c1-14-7-15-9-20(31-22(15)19(8-14)30-4)18-10-17(29-21(18)23(24)25-13-26-29)12-28-6-5-16(11-28)27(2)3/h7-10,13,16H,5-6,11-12H2,1-4H3,(H2,24,25,26)/t16-/m0/s1
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n/an/a 23n/an/an/an/an/an/a



BAYER INTELLETUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant tagged FGFR-3 fusion protein [fusion of glutathione-S-transferase (GST) (N-terminally), His6-tag, thrombin cleavage site, and the intra...


Citation and Details
More data for this
Ligand-Target Pair
GST-Fibroblast growth factor receptor 1 (FGFR-1)


(Homo sapiens (Human))
BDBM255647
PNG
(US9475815, 32)
Show SMILES COc1cc(C)cc2cc(sc12)-c1cc(CNCCN)n2ncnc(N)c12
Show InChI InChI=1S/C19H22N6OS/c1-11-5-12-7-16(27-18(12)15(6-11)26-2)14-8-13(9-22-4-3-20)25-17(14)19(21)23-10-24-25/h5-8,10,22H,3-4,9,20H2,1-2H3,(H2,21,23,24)
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n/an/a 23.3n/an/an/an/an/an/a



BAYER INTELLETUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant tagged FGFR-1 fusion protein [fusion of glutathione-S-transferase (GST) (N-terminally), His6-tag, thrombin cleavage site, and the intra...


Citation and Details
More data for this
Ligand-Target Pair
GST-Fibroblast growth factor receptor 3 (FGFR-3)


(Homo sapiens (Human))
BDBM255706
PNG
(US9475815, 91)
Show SMILES COc1cc(C)cc2cc(sc12)-c1cc(CN2CC(O)C2)n2ncnc(N)c12
Show InChI InChI=1S/C20H21N5O2S/c1-11-3-12-5-17(28-19(12)16(4-11)27-2)15-6-13(7-24-8-14(26)9-24)25-18(15)20(21)22-10-23-25/h3-6,10,14,26H,7-9H2,1-2H3,(H2,21,22,23)
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n/an/a 23.9n/an/an/an/an/an/a



BAYER INTELLETUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant tagged FGFR-3 fusion protein [fusion of glutathione-S-transferase (GST) (N-terminally), His6-tag, thrombin cleavage site, and the intra...


Citation and Details
More data for this
Ligand-Target Pair
GST-Fibroblast growth factor receptor 3 (FGFR-3)


(Homo sapiens (Human))
BDBM255635
PNG
(US9475815, 20)
Show SMILES COc1cc(C)cc2cc(sc12)-c1cc(CN2CCNC(=O)CC2)n2ncnc(N)c12
Show InChI InChI=1S/C22H24N6O2S/c1-13-7-14-9-18(31-21(14)17(8-13)30-2)16-10-15(28-20(16)22(23)25-12-26-28)11-27-5-3-19(29)24-4-6-27/h7-10,12H,3-6,11H2,1-2H3,(H,24,29)(H2,23,25,26)
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n/an/a 24.8n/an/an/an/an/an/a



BAYER INTELLETUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant tagged FGFR-3 fusion protein [fusion of glutathione-S-transferase (GST) (N-terminally), His6-tag, thrombin cleavage site, and the intra...


Citation and Details
More data for this
Ligand-Target Pair
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