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Found 35 Enz. Inhib. hit(s) with all data for entry = 8488
TargetKappa-type opioid receptor(Homo sapiens (Human))
The University Of Bath

US Patent
LigandPNGBDBM50090760(CHEMBL3581750 | US9259422, 30, R = Ph-BU10119 | US...)
Affinity DataKi:  0.0400nMpH: 7.4Assay Description:As Alt et al., 2002. Membranes (20 μg) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presen...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
The University Of Bath

US Patent
LigandPNGBDBM50090731(CHEMBL3581741 | US9259422, 22, R = 3-MePh- BU10112...)
Affinity DataKi:  0.0400nMpH: 7.4Assay Description:As Alt et al., 2002. Membranes (20 μg) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presen...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
The University Of Bath

US Patent
LigandPNGBDBM50090755(CHEMBL3581743 | US9259422, 22, R = 4-FPh- BU10120 ...)
Affinity DataKi:  0.0500nMpH: 7.4Assay Description:As Alt et al., 2002. Membranes (20 μg) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presen...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMu-type opioid receptor(Rattus norvegicus (rat))
The University Of Bath

US Patent
LigandPNGBDBM50090694(CHEMBL3581740 | US9259422, 22, R = Ph-BU128 | US94...)
Affinity DataKi:  0.0800nMpH: 7.4Assay Description:As Alt et al., 2002. Membranes (20 μg) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presen...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
The University Of Bath

US Patent
LigandPNGBDBM50090694(CHEMBL3581740 | US9259422, 22, R = Ph-BU128 | US94...)
Affinity DataKi:  0.0800nMpH: 7.4Assay Description:As Alt et al., 2002. Membranes (20 μg) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presen...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
The University Of Bath

US Patent
LigandPNGBDBM50015009(CHEMBL3262367 | US9259422, 7a, R = 3,5-diMePh- BU1...)
Affinity DataKi:  0.100nMpH: 7.4Assay Description:As Alt et al., 2002. Membranes (20 μg) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presen...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMu-type opioid receptor(Rattus norvegicus (rat))
The University Of Bath

US Patent
LigandPNGBDBM50090760(CHEMBL3581750 | US9259422, 30, R = Ph-BU10119 | US...)
Affinity DataKi:  0.100nMpH: 7.4Assay Description:As Alt et al., 2002. Membranes (20 μg) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presen...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
The University Of Bath

US Patent
LigandPNGBDBM50015011(CHEMBL3262363 | US9259422, 7a, 2-MePh- BU10101 | U...)
Affinity DataKi:  0.160nMpH: 7.4Assay Description:As Alt et al., 2002. Membranes (20 μg) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presen...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMu-type opioid receptor(Rattus norvegicus (rat))
The University Of Bath

US Patent
LigandPNGBDBM50090755(CHEMBL3581743 | US9259422, 22, R = 4-FPh- BU10120 ...)
Affinity DataKi:  0.160nMpH: 7.4Assay Description:As Alt et al., 2002. Membranes (20 μg) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presen...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMu-type opioid receptor(Rattus norvegicus (rat))
The University Of Bath

US Patent
LigandPNGBDBM50090731(CHEMBL3581741 | US9259422, 22, R = 3-MePh- BU10112...)
Affinity DataKi:  0.170nMpH: 7.4Assay Description:As Alt et al., 2002. Membranes (20 μg) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presen...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMu-type opioid receptor(Rattus norvegicus (rat))
The University Of Bath

US Patent
LigandPNGBDBM50015011(CHEMBL3262363 | US9259422, 7a, 2-MePh- BU10101 | U...)
Affinity DataKi:  0.190nMpH: 7.4Assay Description:As Alt et al., 2002. Membranes (20 μg) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presen...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
The University Of Bath

US Patent
LigandPNGBDBM50090760(CHEMBL3581750 | US9259422, 30, R = Ph-BU10119 | US...)
Affinity DataKi:  0.25nMpH: 7.4Assay Description:As Alt et al., 2002. Membranes (20 μg) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presen...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMu-type opioid receptor(Rattus norvegicus (rat))
The University Of Bath

US Patent
LigandPNGBDBM50015009(CHEMBL3262367 | US9259422, 7a, R = 3,5-diMePh- BU1...)
Affinity DataKi:  0.280nMpH: 7.4Assay Description:As Alt et al., 2002. Membranes (20 μg) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presen...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
The University Of Bath

US Patent
LigandPNGBDBM50090731(CHEMBL3581741 | US9259422, 22, R = 3-MePh- BU10112...)
Affinity DataKi:  0.400nMpH: 7.4Assay Description:As Alt et al., 2002. Membranes (20 μg) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presen...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
The University Of Bath

US Patent
LigandPNGBDBM50090755(CHEMBL3581743 | US9259422, 22, R = 4-FPh- BU10120 ...)
Affinity DataKi:  0.470nMpH: 7.4Assay Description:As Alt et al., 2002. Membranes (20 μg) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presen...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
The University Of Bath

US Patent
LigandPNGBDBM50090694(CHEMBL3581740 | US9259422, 22, R = Ph-BU128 | US94...)
Affinity DataKi:  0.480nMpH: 7.4Assay Description:As Alt et al., 2002. Membranes (20 μg) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presen...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
The University Of Bath

US Patent
LigandPNGBDBM50015003(CHEMBL3262089 | US9259422, 7a, R = Ph-BU127 | US94...)
Affinity DataKi:  0.490nMpH: 7.4Assay Description:As Alt et al., 2002. Membranes (20 μg) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presen...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMu-type opioid receptor(Rattus norvegicus (rat))
The University Of Bath

US Patent
LigandPNGBDBM50015004(CHEMBL3262372 | US9259422, 7a, R = 2-thienyl- BU08...)
Affinity DataKi:  0.600nMpH: 7.4Assay Description:As Alt et al., 2002. Membranes (20 μg) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presen...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMu-type opioid receptor(Rattus norvegicus (rat))
The University Of Bath

US Patent
LigandPNGBDBM206331(US9259422, 23, R = Ph-BU129 | US9480684, 23, R = P...)
Affinity DataKi:  0.600nMpH: 7.4Assay Description:As Alt et al., 2002. Membranes (20 μg) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMu-type opioid receptor(Rattus norvegicus (rat))
The University Of Bath

US Patent
LigandPNGBDBM50015003(CHEMBL3262089 | US9259422, 7a, R = Ph-BU127 | US94...)
Affinity DataKi:  0.710nMpH: 7.4Assay Description:As Alt et al., 2002. Membranes (20 μg) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presen...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
The University Of Bath

US Patent
LigandPNGBDBM206331(US9259422, 23, R = Ph-BU129 | US9480684, 23, R = P...)
Affinity DataKi:  1.08nMpH: 7.4Assay Description:As Alt et al., 2002. Membranes (20 μg) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMu-type opioid receptor(Rattus norvegicus (rat))
The University Of Bath

US Patent
LigandPNGBDBM50014995(CHEMBL3262090 | US9259422, 13a, R = Ph-BU126 | US9...)
Affinity DataKi:  1.25nMpH: 7.4Assay Description:As Alt et al., 2002. Membranes (20 μg) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presen...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
The University Of Bath

US Patent
LigandPNGBDBM50015003(CHEMBL3262089 | US9259422, 7a, R = Ph-BU127 | US94...)
Affinity DataKi:  1.91nMpH: 7.4Assay Description:As Alt et al., 2002. Membranes (20 μg) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presen...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
The University Of Bath

US Patent
LigandPNGBDBM50014995(CHEMBL3262090 | US9259422, 13a, R = Ph-BU126 | US9...)
Affinity DataKi:  2.55nMpH: 7.4Assay Description:As Alt et al., 2002. Membranes (20 μg) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presen...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
The University Of Bath

US Patent
LigandPNGBDBM206331(US9259422, 23, R = Ph-BU129 | US9480684, 23, R = P...)
Affinity DataKi:  3.02nMpH: 7.4Assay Description:As Alt et al., 2002. Membranes (20 μg) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
The University Of Bath

US Patent
LigandPNGBDBM50015005(CHEMBL3262093 | US9259422, 13b, R = Ph-BU125 | US9...)
Affinity DataKi:  3.21nMpH: 7.4Assay Description:As Alt et al., 2002. Membranes (20 μg) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presen...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
The University Of Bath

US Patent
LigandPNGBDBM50015005(CHEMBL3262093 | US9259422, 13b, R = Ph-BU125 | US9...)
Affinity DataKi:  3.84nMpH: 7.4Assay Description:As Alt et al., 2002. Membranes (20 μg) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presen...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMu-type opioid receptor(Rattus norvegicus (rat))
The University Of Bath

US Patent
LigandPNGBDBM50015005(CHEMBL3262093 | US9259422, 13b, R = Ph-BU125 | US9...)
Affinity DataKi:  4.03nMpH: 7.4Assay Description:As Alt et al., 2002. Membranes (20 μg) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presen...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
The University Of Bath

US Patent
LigandPNGBDBM50014995(CHEMBL3262090 | US9259422, 13a, R = Ph-BU126 | US9...)
Affinity DataKi:  4.40nMpH: 7.4Assay Description:As Alt et al., 2002. Membranes (20 μg) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presen...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
The University Of Bath

US Patent
LigandPNGBDBM50090755(CHEMBL3581743 | US9259422, 22, R = 4-FPh- BU10120 ...)
Affinity DataKi:  34nMpH: 7.4Assay Description:As Alt et al., 2002. Membranes (20 μg) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presen...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
The University Of Bath

US Patent
LigandPNGBDBM50015004(CHEMBL3262372 | US9259422, 7a, R = 2-thienyl- BU08...)
Affinity DataKi:  34.5nMpH: 7.4Assay Description:As Alt et al., 2002. Membranes (20 μg) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presen...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
The University Of Bath

US Patent
LigandPNGBDBM50015003(CHEMBL3262089 | US9259422, 7a, R = Ph-BU127 | US94...)
Affinity DataKi:  43.2nMpH: 7.4Assay Description:As Alt et al., 2002. Membranes (20 μg) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presen...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
The University Of Bath

US Patent
LigandPNGBDBM50090731(CHEMBL3581741 | US9259422, 22, R = 3-MePh- BU10112...)
Affinity DataKi:  79nMpH: 7.4Assay Description:As Alt et al., 2002. Membranes (20 μg) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presen...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
The University Of Bath

US Patent
LigandPNGBDBM50090760(CHEMBL3581750 | US9259422, 30, R = Ph-BU10119 | US...)
Affinity DataKi:  80nMpH: 7.4Assay Description:As Alt et al., 2002. Membranes (20 μg) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presen...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
The University Of Bath

US Patent
LigandPNGBDBM50090694(CHEMBL3581740 | US9259422, 22, R = Ph-BU128 | US94...)
Affinity DataKi:  97nMpH: 7.4Assay Description:As Alt et al., 2002. Membranes (20 μg) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presen...More data for this Ligand-Target Pair
In DepthDetails US Patent