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Patent code US9481677

Compile Data Set for Download or QSAR
Found 37 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM254126
PNG
(US9481677, 98)
Show SMILES CN(C)c1noc2ccc(cc12)-c1cc(Cl)ccc1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C23H16ClF2N5O4S2/c1-31(2)22-15-7-12(3-5-19(15)35-29-22)14-8-13(24)4-6-18(14)34-20-9-17(26)21(10-16(20)25)37(32,33)30-23-27-11-28-36-23/h3-11H,1-2H3,(H,27,28,30)
PDB

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US Patent
n/an/a 0.200n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nav's), and...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM50118514
PNG
(CHEMBL3617063 | US9481677, 38)
Show SMILES Nc1nc2cc(ccc2[nH]1)-c1cc(Cl)ccc1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H13ClF2N6O3S2/c22-11-2-4-17(12(6-11)10-1-3-15-16(5-10)29-20(25)28-15)33-18-7-14(24)19(8-13(18)23)35(31,32)30-21-26-9-27-34-21/h1-9H,(H3,25,28,29)(H,26,27,30)
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US Patent
n/an/a 0.300n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nav's), and...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM254114
PNG
(US9481677, 52)
Show SMILES Fc1cc(c(F)cc1Oc1ccc(Cl)cc1-c1ccc2oc(=O)[nH]c2c1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H11ClF2N4O5S2/c22-11-2-4-16(12(6-11)10-1-3-17-15(5-10)27-21(29)33-17)32-18-7-14(24)19(8-13(18)23)35(30,31)28-20-25-9-26-34-20/h1-9H,(H,27,29)(H,25,26,28)
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US Patent
n/an/a 0.300n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nav's), and...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM50169426
PNG
(CHEMBL3806065 | US9481677, 69)
Show SMILES CNc1noc2ccc(cc12)-c1cc(Cl)ccc1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C22H14ClF2N5O4S2/c1-26-21-14-6-11(2-4-18(14)34-29-21)13-7-12(23)3-5-17(13)33-19-8-16(25)20(9-15(19)24)36(31,32)30-22-27-10-28-35-22/h2-10H,1H3,(H,26,29)(H,27,28,30)
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n/an/a 0.5n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nav's), and...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM254121
PNG
(US9481677, 64)
Show SMILES Nc1noc2ccc(cc12)-c1cc(Cl)ccc1Oc1cc(F)c(c(F)c1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H12ClF2N5O4S2/c22-11-2-4-17(13(6-11)10-1-3-18-14(5-10)20(25)28-33-18)32-12-7-15(23)19(16(24)8-12)35(30,31)29-21-26-9-27-34-21/h1-9H,(H2,25,28)(H,26,27,29)
PDB

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US Patent
n/an/a 0.5n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nav's), and...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM50169425
PNG
(CHEMBL3341983 | US9481677, 44)
Show SMILES Nc1noc2ccc(cc12)-c1cc(Cl)ccc1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H12ClF2N5O4S2/c22-11-2-4-16(12(6-11)10-1-3-17-13(5-10)20(25)28-33-17)32-18-7-15(24)19(8-14(18)23)35(30,31)29-21-26-9-27-34-21/h1-9H,(H2,25,28)(H,26,27,29)
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n/an/a 0.600n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nav's), and...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM254125
PNG
(US9481677, 82)
Show SMILES Cc1ccc(Oc2cc(F)c(cc2F)S(=O)(=O)Nc2ncns2)c(c1)-c1ccc2oc(=O)[nH]c2c1
Show InChI InChI=1S/C22H14F2N4O5S2/c1-11-2-4-17(13(6-11)12-3-5-18-16(7-12)27-22(29)33-18)32-19-8-15(24)20(9-14(19)23)35(30,31)28-21-25-10-26-34-21/h2-10H,1H3,(H,27,29)(H,25,26,28)
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n/an/a 0.700n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nav's), and...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM254119
PNG
(US9481677, 57)
Show SMILES Nc1nc2ccc(cc2o1)-c1cc(Cl)ccc1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H12ClF2N5O4S2/c22-11-2-4-16(12(6-11)10-1-3-15-18(5-10)33-20(25)28-15)32-17-7-14(24)19(8-13(17)23)35(30,31)29-21-26-9-27-34-21/h1-9H,(H2,25,28)(H,26,27,29)
PDB

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n/an/a 0.800n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nav's), and...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM254117
PNG
(US9481677, 55)
Show SMILES Fc1cc(c(F)cc1Oc1ccc(Cl)cc1-c1ccc2CC(=O)Nc2c1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C22H13ClF2N4O4S2/c23-13-3-4-18(14(7-13)11-1-2-12-6-21(30)28-17(12)5-11)33-19-8-16(25)20(9-15(19)24)35(31,32)29-22-26-10-27-34-22/h1-5,7-10H,6H2,(H,28,30)(H,26,27,29)
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n/an/a 1n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nav's), and...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM254113
PNG
(US9481677, 51)
Show SMILES Fc1cc(c(F)cc1Oc1ccc(Cl)cc1-c1ccc2ocnc2c1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H11ClF2N4O4S2/c22-12-2-4-17(13(6-12)11-1-3-18-16(5-11)26-10-31-18)32-19-7-15(24)20(8-14(19)23)34(29,30)28-21-25-9-27-33-21/h1-10H,(H,25,27,28)
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n/an/a 1n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nav's), and...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM254120
PNG
(US9481677, 62)
Show SMILES Nc1nc2cc(ccc2[nH]1)-c1cc(Cl)ccc1Oc1cc(F)c(c(F)c1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H13ClF2N6O3S2/c22-11-2-4-18(13(6-11)10-1-3-16-17(5-10)29-20(25)28-16)33-12-7-14(23)19(15(24)8-12)35(31,32)30-21-26-9-27-34-21/h1-9H,(H3,25,28,29)(H,26,27,30)
PDB

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US Patent
n/an/a 1.20n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nav's), and...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM254116
PNG
(US9481677, 54)
Show SMILES Fc1cc(c(F)cc1Oc1ccc(Cl)cc1-c1ccc2[nH]c(nc2c1)C(F)(F)F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C22H11ClF5N5O3S2/c23-11-2-4-17(12(6-11)10-1-3-15-16(5-10)32-20(31-15)22(26,27)28)36-18-7-14(25)19(8-13(18)24)38(34,35)33-21-29-9-30-37-21/h1-9H,(H,31,32)(H,29,30,33)
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n/an/a 1.40n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nav's), and...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM254118
PNG
(US9481677, 56)
Show SMILES Nc1nc2cc(ccc2o1)-c1cc(Cl)ccc1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H12ClF2N5O4S2/c22-11-2-4-16(12(6-11)10-1-3-17-15(5-10)28-20(25)33-17)32-18-7-14(24)19(8-13(18)23)35(30,31)29-21-26-9-27-34-21/h1-9H,(H2,25,28)(H,26,27,29)
PDB

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n/an/a 1.40n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nav's), and...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM50169434
PNG
(CHEMBL3805837 | US9481677, 80)
Show SMILES Nc1noc2ccc(cc12)-c1cc(F)ccc1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H12F3N5O4S2/c22-11-2-4-16(12(6-11)10-1-3-17-13(5-10)20(25)28-33-17)32-18-7-15(24)19(8-14(18)23)35(30,31)29-21-26-9-27-34-21/h1-9H,(H2,25,28)(H,26,27,29)
PDB

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US Patent
n/an/a 1.70n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nav's), and...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM50169432
PNG
(CHEMBL3805973 | US9481677, 48)
Show SMILES Fc1cc(c(F)cc1Oc1ccc(Cl)cc1-c1ccc2[nH]c(=O)[nH]c2c1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H12ClF2N5O4S2/c22-11-2-4-17(12(6-11)10-1-3-15-16(5-10)28-20(30)27-15)33-18-7-14(24)19(8-13(18)23)35(31,32)29-21-25-9-26-34-21/h1-9H,(H,25,26,29)(H2,27,28,30)
PDB

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US Patent
n/an/a 1.70n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nav's), and...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM50169431
PNG
(CHEMBL3805722 | US9481677, 73)
Show SMILES Fc1cc(c(F)cc1Oc1ccc(Cl)cc1-c1ccc2[nH]cnc2c1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H12ClF2N5O3S2/c22-12-2-4-18(13(6-12)11-1-3-16-17(5-11)26-9-25-16)32-19-7-15(24)20(8-14(19)23)34(30,31)29-21-27-10-28-33-21/h1-10H,(H,25,26)(H,27,28,29)
PDB

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US Patent
n/an/a 1.70n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nav's), and...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM254122
PNG
(US9481677, 65)
Show SMILES Nc1noc2ccc(cc12)-c1cc(Cl)ccc1Oc1ccc(c(F)c1F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H12ClF2N5O4S2/c22-11-2-4-14(12(8-11)10-1-3-15-13(7-10)20(25)28-33-15)32-16-5-6-17(19(24)18(16)23)35(30,31)29-21-26-9-27-34-21/h1-9H,(H2,25,28)(H,26,27,29)
PDB

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n/an/a 1.80n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nav's), and...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM50169433
PNG
(CHEMBL3805201 | US9481677, 58)
Show SMILES Nc1noc2ccc(cc12)-c1ccccc1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H13F2N5O4S2/c22-14-9-19(34(29,30)28-21-25-10-26-33-21)15(23)8-18(14)31-16-4-2-1-3-12(16)11-5-6-17-13(7-11)20(24)27-32-17/h1-10H,(H2,24,27)(H,25,26,28)
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n/an/a 3n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nav's), and...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM254111
PNG
(US9481677, 42)
Show SMILES Nc1cnc2ccc(cn12)-c1cc(Cl)ccc1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H13ClF2N6O3S2/c22-12-2-3-16(13(5-12)11-1-4-20-26-8-19(25)30(20)9-11)33-17-6-15(24)18(7-14(17)23)35(31,32)29-21-27-10-28-34-21/h1-10H,25H2,(H,27,28,29)
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n/an/a 3.5n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nav's), and...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM50169430
PNG
(CHEMBL3805347 | US9481677, 59)
Show SMILES Fc1cc(c(F)cc1Oc1ccc(Cl)cc1-c1ccc2nccnc2c1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C22H12ClF2N5O3S2/c23-13-2-4-19(14(8-13)12-1-3-17-18(7-12)27-6-5-26-17)33-20-9-16(25)21(10-15(20)24)35(31,32)30-22-28-11-29-34-22/h1-11H,(H,28,29,30)
PDB

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US Patent
n/an/a 3.60n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nav's), and...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM50169438
PNG
(CHEMBL3804898 | US9481677, 63)
Show SMILES Nc1noc2ccc(cc12)-c1cc(Cl)ccc1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ncccn1
Show InChI InChI=1S/C23H14ClF2N5O4S/c24-13-3-5-18(14(9-13)12-2-4-19-15(8-12)22(27)30-35-19)34-20-10-17(26)21(11-16(20)25)36(32,33)31-23-28-6-1-7-29-23/h1-11H,(H2,27,30)(H,28,29,31)
PDB

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n/an/a 4.40n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nav's), and...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM50169427
PNG
(CHEMBL3805897 | US9481677, 45)
Show SMILES Nc1n[nH]c2ccc(cc12)-c1cc(Cl)ccc1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H13ClF2N6O3S2/c22-11-2-4-17(12(6-11)10-1-3-16-13(5-10)20(25)29-28-16)33-18-7-15(24)19(8-14(18)23)35(31,32)30-21-26-9-27-34-21/h1-9H,(H3,25,28,29)(H,26,27,30)
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n/an/a 5.30n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nav's), and...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM254123
PNG
(US9481677, 77)
Show SMILES Fc1cc(c(F)cc1Oc1ccc(Cl)cc1-c1ccc2NC(=O)Cc2c1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C22H13ClF2N4O4S2/c23-13-2-4-18(14(7-13)11-1-3-17-12(5-11)6-21(30)28-17)33-19-8-16(25)20(9-15(19)24)35(31,32)29-22-26-10-27-34-22/h1-5,7-10H,6H2,(H,28,30)(H,26,27,29)
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n/an/a 7.40n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nav's), and...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM254105
PNG
(US9481677, 31)
Show SMILES Fc1cc(c(F)cc1Oc1ccc(Cl)cc1-c1ccnc2nccn12)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H11ClF2N6O3S2/c21-11-1-2-16(12(7-11)15-3-4-24-19-25-5-6-29(15)19)32-17-8-14(23)18(9-13(17)22)34(30,31)28-20-26-10-27-33-20/h1-10H,(H,26,27,28)
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n/an/a 8n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nav's), and...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM50169437
PNG
(CHEMBL3805563 | US9481677, 49)
Show SMILES Nc1noc2ccc(cc12)-c1cc(Cl)ccc1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C22H13ClF2N4O4S2/c23-12-2-4-17(13(6-12)11-1-3-18-14(5-11)22(26)28-33-18)32-19-7-16(25)20(8-15(19)24)35(30,31)29-21-9-34-10-27-21/h1-10,29H,(H2,26,28)
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n/an/a 8.70n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nav's), and...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM254124
PNG
(US9481677, 79)
Show SMILES Fc1cc(ccc1Oc1ccc(Cl)cc1-c1ccc2oc(=O)[nH]c2c1)S(=O)(=O)Nc1ncccn1
Show InChI InChI=1S/C23H14ClFN4O5S/c24-14-3-6-19(16(11-14)13-2-5-21-18(10-13)28-23(30)34-21)33-20-7-4-15(12-17(20)25)35(31,32)29-22-26-8-1-9-27-22/h1-12H,(H,28,30)(H,26,27,29)
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n/an/a 10.8n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nav's), and...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM50169424
PNG
(CHEMBL3805265 | US9481677, 30)
Show SMILES Fc1cc(c(F)cc1Oc1ccc(Cl)cc1-c1cccc2nccn12)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H12ClF2N5O3S2/c22-12-4-5-17(13(8-12)16-2-1-3-20-25-6-7-29(16)20)32-18-9-15(24)19(10-14(18)23)34(30,31)28-21-26-11-27-33-21/h1-11H,(H,26,27,28)
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n/an/a 13.4n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nav's), and...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM254112
PNG
(US9481677, 46)
Show SMILES NC(=O)c1cnc2ccc(cn12)-c1cc(Cl)ccc1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C22H13ClF2N6O4S2/c23-12-2-3-17(13(5-12)11-1-4-20-27-8-16(21(26)32)31(20)9-11)35-18-6-15(25)19(7-14(18)24)37(33,34)30-22-28-10-29-36-22/h1-10H,(H2,26,32)(H,28,29,30)
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n/an/a 17.4n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nav's), and...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM254115
PNG
(US9481677, 53)
Show SMILES Fc1cc(c(F)cc1Oc1ccc(Cl)cc1-c1ccc2[nH]c(=O)oc2c1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H11ClF2N4O5S2/c22-11-2-4-16(12(6-11)10-1-3-15-18(5-10)33-21(29)27-15)32-17-7-14(24)19(8-13(17)23)35(30,31)28-20-25-9-26-34-20/h1-9H,(H,27,29)(H,25,26,28)
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n/an/a 17.9n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nav's), and...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM254106
PNG
(US9481677, 34.24)
Show SMILES Fc1cccnc1NS(=O)(=O)c1cc(F)c(Oc2ccc(Cl)cc2-c2cccc3nccn23)cc1F
Show InChI InChI=1S/C24H14ClF3N4O3S/c25-14-6-7-20(15(11-14)19-4-1-5-23-29-9-10-32(19)23)35-21-12-18(28)22(13-17(21)27)36(33,34)31-24-16(26)3-2-8-30-24/h1-13H,(H,30,31)
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n/an/a 23.2n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nav's), and...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM50169435
PNG
(CHEMBL3805138 | US9481677, 86)
Show SMILES Nc1noc2ccc(cc12)-c1cccnc1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H12F2N6O4S2/c21-13-8-17(34(29,30)28-20-25-9-26-33-20)14(22)7-16(13)31-19-11(2-1-5-24-19)10-3-4-15-12(6-10)18(23)27-32-15/h1-9H,(H2,23,27)(H,25,26,28)
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n/an/a 51n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nav's), and...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM254110
PNG
(US9481677, 41)
Show SMILES CN(c1ncns1)S(=O)(=O)c1cc(F)c(Oc2ccc(Cl)cc2-c2ccc3[nH]c(N)nc3c2)cc1F
Show InChI InChI=1S/C22H15ClF2N6O3S2/c1-31(22-27-10-28-35-22)36(32,33)20-9-14(24)19(8-15(20)25)34-18-5-3-12(23)7-13(18)11-2-4-16-17(6-11)30-21(26)29-16/h2-10H,1H3,(H3,26,29,30)
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n/an/a 67.8n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nav's), and...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM50169429
PNG
(CHEMBL3805199 | US9481677, 32)
Show SMILES Fc1cc(c(F)cc1Oc1ccc(Cl)cc1-c1cnc2CNCCn12)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H15ClF2N6O3S2/c21-11-1-2-16(12(5-11)15-8-25-19-9-24-3-4-29(15)19)32-17-6-14(23)18(7-13(17)22)34(30,31)28-20-26-10-27-33-20/h1-2,5-8,10,24H,3-4,9H2,(H,26,27,28)
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n/an/a 222n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nav's), and...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM254107
PNG
(US9481677, 35)
Show SMILES Fc1cc(c(F)cc1Oc1ccc(Cl)cc1-c1c[nH]c(=O)c2cncn12)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H11ClF2N6O4S2/c21-10-1-2-16(11(3-10)14-7-25-19(30)15-6-24-9-29(14)15)33-17-4-13(23)18(5-12(17)22)35(31,32)28-20-26-8-27-34-20/h1-9H,(H,25,30)(H,26,27,28)
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n/an/a 675n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nav's), and...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM50169428
PNG
(CHEMBL3805875 | US9481677, 36)
Show SMILES Fc1cc(c(F)cc1Oc1ccc(Cl)cc1-c1ncc2cnccn12)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H11ClF2N6O3S2/c21-11-1-2-16(13(5-11)19-25-9-12-8-24-3-4-29(12)19)32-17-6-15(23)18(7-14(17)22)34(30,31)28-20-26-10-27-33-20/h1-10H,(H,26,27,28)
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n/an/a 2.31E+3n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nav's), and...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM254108
PNG
(US9481677, 39)
Show SMILES Cn1cnc2c(ncnc12)-c1cc(Cl)ccc1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H12ClF2N7O3S2/c1-30-9-27-18-17(24-7-25-19(18)30)11-4-10(21)2-3-14(11)33-15-5-13(23)16(6-12(15)22)35(31,32)29-20-26-8-28-34-20/h2-9H,1H3,(H,26,28,29)
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n/an/a 2.38E+3n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nav's), and...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM254109
PNG
(US9481677, 40)
Show SMILES Fc1cc(c(F)cc1Oc1ccc(Cl)cc1-n1cnc2cncnc12)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C19H10ClF2N7O3S2/c20-10-1-2-15(14(3-10)29-9-26-13-6-23-7-24-18(13)29)32-16-4-12(22)17(5-11(16)21)34(30,31)28-19-25-8-27-33-19/h1-9H,(H,25,27,28)
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n/an/a 3.38E+3n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nav's), and...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%