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Patent code US9487483

Compile Data Set for Download or QSAR
Found 128 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Factor D


(Homo sapiens (Human))
BDBM256239
PNG
(US9487483, 91)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@@H]2CCCC(Cl)(Cl)C2)c2ccccc12
Show InChI InChI=1S/C23H26Cl2N4O3/c1-13(30)21-16-6-2-3-7-17(16)28(27-21)12-20(31)29-18-9-14(18)10-19(29)22(32)26-15-5-4-8-23(24,25)11-15/h2-3,6-7,14-15,18-19H,4-5,8-12H2,1H3,(H,26,32)/t14-,15-,18-,19+/m1/s1
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Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256178
PNG
(US9487483, 30)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NN2CCCC(C)(C)C2)c2ccc(OCc3ncccn3)cc12
Show InChI InChI=1S/C29H35N7O4/c1-18(37)27-21-14-20(40-16-25-30-9-5-10-31-25)6-7-22(21)35(32-27)15-26(38)36-23-12-19(23)13-24(36)28(39)33-34-11-4-8-29(2,3)17-34/h5-7,9-10,14,19,23-24H,4,8,11-13,15-17H2,1-3H3,(H,33,39)/t19-,23-,24+/m1/s1
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Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256272
PNG
(US9487483, 124)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@H]2C[C@H](O)CC(C)(C)C2)c2ccccc12
Show InChI InChI=1S/C25H32N4O4/c1-14(30)23-18-6-4-5-7-19(18)28(27-23)13-22(32)29-20-8-15(20)9-21(29)24(33)26-16-10-17(31)12-25(2,3)11-16/h4-7,15-17,20-21,31H,8-13H2,1-3H3,(H,26,33)/t15-,16+,17+,20-,21+/m1/s1
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Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256259
PNG
(US9487483, 111)
Show SMILES CC1(C)CCC[C@H](C1)NC(=O)[C@@H]1C[C@@]2(CO)C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccccc12
Show InChI InChI=1S/C25H33N5O4/c1-24(2)9-5-6-15(10-24)27-23(34)18-11-25(14-31)12-19(25)30(18)20(32)13-29-17-8-4-3-7-16(17)21(28-29)22(26)33/h3-4,7-8,15,18-19,31H,5-6,9-14H2,1-2H3,(H2,26,33)(H,27,34)/t15-,18+,19-,25+/m1/s1
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Novartis AG

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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256246
PNG
(US9487483, 98)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@@H]2CCCC(C)(C)C2)c2ccc(OCc3ncccn3)cc12
Show InChI InChI=1S/C30H36N6O4/c1-18(37)28-22-14-21(40-17-26-31-10-5-11-32-26)7-8-23(22)35(34-28)16-27(38)36-24-12-19(24)13-25(36)29(39)33-20-6-4-9-30(2,3)15-20/h5,7-8,10-11,14,19-20,24-25H,4,6,9,12-13,15-17H2,1-3H3,(H,33,39)/t19-,20-,24-,25+/m1/s1
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Novartis AG

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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256170
PNG
(US9487483, 22)
Show SMILES CC1(C)CCC[C@H](C1)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Nc1cn(C(N)=O)c2ccccc12
Show InChI InChI=1S/C24H31N5O3/c1-24(2)9-5-6-15(12-24)26-21(30)20-11-14-10-19(14)29(20)23(32)27-17-13-28(22(25)31)18-8-4-3-7-16(17)18/h3-4,7-8,13-15,19-20H,5-6,9-12H2,1-2H3,(H2,25,31)(H,26,30)(H,27,32)/t14-,15-,19-,20+/m1/s1
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Novartis AG

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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256269
PNG
(US9487483, 121)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@]3(CO)C[C@H]2C(=O)N[C@@H]2CCCC(C)(C)C2)c2cnccc12
Show InChI InChI=1S/C25H33N5O4/c1-15(32)22-17-6-8-26-12-19(17)29(28-22)13-21(33)30-18(10-25(14-31)11-20(25)30)23(34)27-16-5-4-7-24(2,3)9-16/h6,8,12,16,18,20,31H,4-5,7,9-11,13-14H2,1-3H3,(H,27,34)/t16-,18+,20-,25+/m1/s1
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Novartis AG

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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256171
PNG
(US9487483, 23)
Show SMILES CC[C@H]1CCC[C@H](C1)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Nc1cn(C(N)=O)c2ccccc12
Show InChI InChI=1S/C24H31N5O3/c1-2-14-6-5-7-16(10-14)26-22(30)21-12-15-11-20(15)29(21)24(32)27-18-13-28(23(25)31)19-9-4-3-8-17(18)19/h3-4,8-9,13-16,20-21H,2,5-7,10-12H2,1H3,(H2,25,31)(H,26,30)(H,27,32)/t14-,15+,16+,20+,21-/m0/s1
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Novartis AG

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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256265
PNG
(US9487483, 117)
Show SMILES CC[C@H]1CCC[C@H](C1)NC(=O)[C@@H]1C[C@@]2(CO)C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccccc12
Show InChI InChI=1S/C25H33N5O4/c1-2-15-6-5-7-16(10-15)27-24(34)19-11-25(14-31)12-20(25)30(19)21(32)13-29-18-9-4-3-8-17(18)22(28-29)23(26)33/h3-4,8-9,15-16,19-20,31H,2,5-7,10-14H2,1H3,(H2,26,33)(H,27,34)/t15-,16+,19-,20+,25-/m0/s1
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Novartis AG

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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256254
PNG
(US9487483, 106)
Show SMILES CO[C@H]1C[C@@H](CC(C)(C)C1)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccccc12
Show InChI InChI=1S/C25H33N5O4/c1-25(2)11-15(10-16(12-25)34-3)27-24(33)20-9-14-8-19(14)30(20)21(31)13-29-18-7-5-4-6-17(18)22(28-29)23(26)32/h4-7,14-16,19-20H,8-13H2,1-3H3,(H2,26,32)(H,27,33)/t14-,15+,16+,19-,20+/m1/s1
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Novartis AG

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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256208
PNG
(US9487483, 60)
Show SMILES CC1(C)CCC[C@H](C1)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccc(F)cc12
Show InChI InChI=1S/C24H30FN5O3/c1-24(2)7-3-4-15(11-24)27-23(33)19-9-13-8-17(13)30(19)20(31)12-29-18-10-14(25)5-6-16(18)21(28-29)22(26)32/h5-6,10,13,15,17,19H,3-4,7-9,11-12H2,1-2H3,(H2,26,32)(H,27,33)/t13-,15-,17-,19+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256153
PNG
(US9487483, 5)
Show SMILES CC1CC(CC(C)(C)C1)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(C)=O)c2cccnc12
Show InChI InChI=1S/C25H33N5O3/c1-14-8-17(12-25(3,4)11-14)27-24(33)20-10-16-9-19(16)30(20)21(32)13-29-23-18(6-5-7-26-23)22(28-29)15(2)31/h5-7,14,16-17,19-20H,8-13H2,1-4H3,(H,27,33)/t14?,16-,17?,19-,20+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256263
PNG
(US9487483, 115)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@]3(CO)C[C@H]2C(=O)N[C@@H]2CCCC(C)(C)C2)c2ncccc12
Show InChI InChI=1S/C25H33N5O4/c1-15(32)21-17-7-5-9-26-22(17)29(28-21)13-20(33)30-18(11-25(14-31)12-19(25)30)23(34)27-16-6-4-8-24(2,3)10-16/h5,7,9,16,18-19,31H,4,6,8,10-14H2,1-3H3,(H,27,34)/t16-,18+,19-,25+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256210
PNG
(US9487483, 62)
Show SMILES CC1(C)CCC[C@H](C1)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccc(Cl)cc12
Show InChI InChI=1S/C24H30ClN5O3/c1-24(2)7-3-4-15(11-24)27-23(33)19-9-13-8-17(13)30(19)20(31)12-29-18-10-14(25)5-6-16(18)21(28-29)22(26)32/h5-6,10,13,15,17,19H,3-4,7-9,11-12H2,1-2H3,(H2,26,32)(H,27,33)/t13-,15-,17-,19+/m1/s1
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Novartis AG

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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256212
PNG
(US9487483, 64)
Show SMILES CCc1cc2c(nn(CC(=O)N3[C@@H]4C[C@@H]4C[C@H]3C(=O)N[C@@H]3CCCC(C)(C)C3)c2cn1)C(N)=O
Show InChI InChI=1S/C25H34N6O3/c1-4-15-10-17-20(12-27-15)30(29-22(17)23(26)33)13-21(32)31-18-8-14(18)9-19(31)24(34)28-16-6-5-7-25(2,3)11-16/h10,12,14,16,18-19H,4-9,11,13H2,1-3H3,(H2,26,33)(H,28,34)/t14-,16-,18-,19+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256187
PNG
(US9487483, 37)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@@H]2CCCCC2(F)F)c2ccc(OCc3ncccn3)cc12
Show InChI InChI=1S/C28H30F2N6O4/c1-16(37)26-19-13-18(40-15-24-31-9-4-10-32-24)6-7-20(19)35(34-26)14-25(38)36-21-11-17(21)12-22(36)27(39)33-23-5-2-3-8-28(23,29)30/h4,6-7,9-10,13,17,21-23H,2-3,5,8,11-12,14-15H2,1H3,(H,33,39)/t17-,21-,22+,23-/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256243
PNG
(US9487483, 95)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@@H]2CCC[C@@H](C2)C(F)(F)F)c2ccc(OCc3ncccn3)cc12
Show InChI InChI=1S/C29H31F3N6O4/c1-16(39)27-21-13-20(42-15-25-33-8-3-9-34-25)6-7-22(21)37(36-27)14-26(40)38-23-10-17(23)11-24(38)28(41)35-19-5-2-4-18(12-19)29(30,31)32/h3,6-9,13,17-19,23-24H,2,4-5,10-12,14-15H2,1H3,(H,35,41)/t17-,18+,19-,23-,24+/m1/s1
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US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256174
PNG
(US9487483, 26)
Show SMILES NC(=O)n1cc(NC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@@H]2CCC[C@@H](C2)C(F)(F)F)c2ccccc12
Show InChI InChI=1S/C23H26F3N5O3/c24-23(25,26)13-4-3-5-14(10-13)28-20(32)19-9-12-8-18(12)31(19)22(34)29-16-11-30(21(27)33)17-7-2-1-6-15(16)17/h1-2,6-7,11-14,18-19H,3-5,8-10H2,(H2,27,33)(H,28,32)(H,29,34)/t12-,13+,14-,18-,19+/m1/s1
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Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256173
PNG
(US9487483, 25)
Show SMILES C[C@H]1CCC[C@H](C1)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Nc1cn(C(N)=O)c2ccccc12
Show InChI InChI=1S/C23H29N5O3/c1-13-5-4-6-15(9-13)25-21(29)20-11-14-10-19(14)28(20)23(31)26-17-12-27(22(24)30)18-8-3-2-7-16(17)18/h2-3,7-8,12-15,19-20H,4-6,9-11H2,1H3,(H2,24,30)(H,25,29)(H,26,31)/t13-,14+,15+,19+,20-/m0/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256177
PNG
(US9487483, 29)
Show SMILES Cc1cc2c(nn(CC(=O)N3[C@@H]4C[C@@H]4C[C@H]3C(=O)NN3CCCC(C)(C)C3)c2cn1)C(N)=O
Show InChI InChI=1S/C23H31N7O3/c1-13-7-15-18(10-25-13)29(26-20(15)21(24)32)11-19(31)30-16-8-14(16)9-17(30)22(33)27-28-6-4-5-23(2,3)12-28/h7,10,14,16-17H,4-6,8-9,11-12H2,1-3H3,(H2,24,32)(H,27,33)/t14-,16-,17+/m1/s1
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Novartis AG

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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256257
PNG
(US9487483, 109)
Show SMILES CC1(C)C[C@@H](O)C[C@@H](C1)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccccc12
Show InChI InChI=1S/C24H31N5O4/c1-24(2)10-14(9-15(30)11-24)26-23(33)19-8-13-7-18(13)29(19)20(31)12-28-17-6-4-3-5-16(17)21(27-28)22(25)32/h3-6,13-15,18-19,30H,7-12H2,1-2H3,(H2,25,32)(H,26,33)/t13-,14+,15+,18-,19+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256197
PNG
(US9487483, 49)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@@H]2CCC[C@@H](C2)C(F)(F)F)c2ccccc12
Show InChI InChI=1S/C23H26F3N5O3/c24-23(25,26)13-4-3-5-14(10-13)28-22(34)18-9-12-8-17(12)31(18)19(32)11-30-16-7-2-1-6-15(16)20(29-30)21(27)33/h1-2,6-7,12-14,17-18H,3-5,8-11H2,(H2,27,33)(H,28,34)/t12-,13+,14-,17-,18+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256221
PNG
(US9487483, 73)
Show SMILES CC[C@H]1CCC[C@H](C1)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccncc12
Show InChI InChI=1S/C23H30N6O3/c1-2-13-4-3-5-15(8-13)26-23(32)18-10-14-9-17(14)29(18)20(30)12-28-19-11-25-7-6-16(19)21(27-28)22(24)31/h6-7,11,13-15,17-18H,2-5,8-10,12H2,1H3,(H2,24,31)(H,26,32)/t13-,14+,15+,17+,18-/m0/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256209
PNG
(US9487483, 61)
Show SMILES Cc1ccc2c(nn(CC(=O)N3[C@@H]4C[C@@H]4C[C@H]3C(=O)N[C@@H]3CCCC(C)(C)C3)c2c1)C(N)=O
Show InChI InChI=1S/C25H33N5O3/c1-14-6-7-17-19(9-14)29(28-22(17)23(26)32)13-21(31)30-18-10-15(18)11-20(30)24(33)27-16-5-4-8-25(2,3)12-16/h6-7,9,15-16,18,20H,4-5,8,10-13H2,1-3H3,(H2,26,32)(H,27,33)/t15-,16-,18-,20+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256236
PNG
(US9487483, 88)
Show SMILES CC1(C)CCC[C@H](C1)NC(=O)[C@@H]1[C@@H]2C[C@@H]2CN1C(=O)Cn1nc(C(N)=O)c2ccccc12
Show InChI InChI=1S/C24H31N5O3/c1-24(2)9-5-6-15(11-24)26-23(32)21-17-10-14(17)12-28(21)19(30)13-29-18-8-4-3-7-16(18)20(27-29)22(25)31/h3-4,7-8,14-15,17,21H,5-6,9-13H2,1-2H3,(H2,25,31)(H,26,32)/t14-,15-,17-,21+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256251
PNG
(US9487483, 103)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC2CC(C)(C)C2)c2ccc(OCc3ncccn3)cc12
Show InChI InChI=1S/C28H32N6O4/c1-16(35)26-20-11-19(38-15-24-29-7-4-8-30-24)5-6-21(20)33(32-26)14-25(36)34-22-9-17(22)10-23(34)27(37)31-18-12-28(2,3)13-18/h4-8,11,17-18,22-23H,9-10,12-15H2,1-3H3,(H,31,37)/t17-,22-,23+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256204
PNG
(US9487483, 56)
Show SMILES CC1(C)CCC[C@H](C1)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccncc12
Show InChI InChI=1S/C23H30N6O3/c1-23(2)6-3-4-14(10-23)26-22(32)17-9-13-8-16(13)29(17)19(30)12-28-18-11-25-7-5-15(18)20(27-28)21(24)31/h5,7,11,13-14,16-17H,3-4,6,8-10,12H2,1-2H3,(H2,24,31)(H,26,32)/t13-,14-,16-,17+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256213
PNG
(US9487483, 65)
Show SMILES Cc1nccc2c(nn(CC(=O)N3[C@@H]4C[C@@H]4C[C@H]3C(=O)N[C@@H]3CCCC(C)(C)C3)c12)C(N)=O
Show InChI InChI=1S/C24H32N6O3/c1-13-21-16(6-8-26-13)20(22(25)32)28-29(21)12-19(31)30-17-9-14(17)10-18(30)23(33)27-15-5-4-7-24(2,3)11-15/h6,8,14-15,17-18H,4-5,7,9-12H2,1-3H3,(H2,25,32)(H,27,33)/t14-,15-,17-,18+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256230
PNG
(US9487483, 82)
Show SMILES CC1(C)CCC[C@H](C1)NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1nc(C(N)=O)c2ccccc12
Show InChI InChI=1S/C23H30FN5O3/c1-23(2)9-5-6-15(11-23)26-22(32)18-10-14(24)12-28(18)19(30)13-29-17-8-4-3-7-16(17)20(27-29)21(25)31/h3-4,7-8,14-15,18H,5-6,9-13H2,1-2H3,(H2,25,31)(H,26,32)/t14-,15-,18+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256229
PNG
(US9487483, 81)
Show SMILES CCc1cc2c(nn(CC(=O)N3C[C@H](F)C[C@H]3C(=O)N[C@@H]3CCCC(C)(C)C3)c2cn1)C(N)=O
Show InChI InChI=1S/C24H33FN6O3/c1-4-15-9-17-19(11-27-15)31(29-21(17)22(26)33)13-20(32)30-12-14(25)8-18(30)23(34)28-16-6-5-7-24(2,3)10-16/h9,11,14,16,18H,4-8,10,12-13H2,1-3H3,(H2,26,33)(H,28,34)/t14-,16-,18+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256175
PNG
(US9487483, 27)
Show SMILES CC1(C)CCC[C@H](C1)NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Nc1cn(C(N)=O)c2ccccc12
Show InChI InChI=1S/C23H30FN5O3/c1-23(2)9-5-6-15(11-23)26-20(30)19-10-14(24)12-29(19)22(32)27-17-13-28(21(25)31)18-8-4-3-7-16(17)18/h3-4,7-8,13-15,19H,5-6,9-12H2,1-2H3,(H2,25,31)(H,26,30)(H,27,32)/t14-,15-,19+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256219
PNG
(US9487483, 71)
Show SMILES CC1(C)CCC[C@H](C1)NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1nc(C(N)=O)c2ccncc12
Show InChI InChI=1S/C22H29FN6O3/c1-22(2)6-3-4-14(9-22)26-21(32)16-8-13(23)11-28(16)18(30)12-29-17-10-25-7-5-15(17)19(27-29)20(24)31/h5,7,10,13-14,16H,3-4,6,8-9,11-12H2,1-2H3,(H2,24,31)(H,26,32)/t13-,14-,16+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256206
PNG
(US9487483, 58)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@H]2CCCC3(CC3)C2)c2ccccc12
Show InChI InChI=1S/C24H29N5O3/c25-22(31)21-16-5-1-2-6-17(16)28(27-21)13-20(30)29-18-10-14(18)11-19(29)23(32)26-15-4-3-7-24(12-15)8-9-24/h1-2,5-6,14-15,18-19H,3-4,7-13H2,(H2,25,31)(H,26,32)/t14-,15+,18-,19+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256207
PNG
(US9487483, 59)
Show SMILES Cc1ccc2n(CC(=O)N3[C@@H]4C[C@@H]4C[C@H]3C(=O)N[C@@H]3CCCC(C)(C)C3)nc(C(N)=O)c2c1
Show InChI InChI=1S/C25H33N5O3/c1-14-6-7-18-17(9-14)22(23(26)32)28-29(18)13-21(31)30-19-10-15(19)11-20(30)24(33)27-16-5-4-8-25(2,3)12-16/h6-7,9,15-16,19-20H,4-5,8,10-13H2,1-3H3,(H2,26,32)(H,27,33)/t15-,16-,19-,20+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256258
PNG
(US9487483, 110)
Show SMILES CC1(C)CCCC(C1)NC(=O)[C@@H]1C[C@@]2(CO)C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccccc12
Show InChI InChI=1S/C25H33N5O4/c1-24(2)9-5-6-15(10-24)27-23(34)18-11-25(14-31)12-19(25)30(18)20(32)13-29-17-8-4-3-7-16(17)21(28-29)22(26)33/h3-4,7-8,15,18-19,31H,5-6,9-14H2,1-2H3,(H2,26,33)(H,27,34)/t15?,18-,19+,25-/m0/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256211
PNG
(US9487483, 63)
Show SMILES Cc1cc2c(nn(CC(=O)N3[C@@H]4C[C@@H]4C[C@H]3C(=O)N[C@@H]3CCCC(C)(C)C3)c2cn1)C(N)=O
Show InChI InChI=1S/C24H32N6O3/c1-13-7-16-19(11-26-13)29(28-21(16)22(25)32)12-20(31)30-17-8-14(17)9-18(30)23(33)27-15-5-4-6-24(2,3)10-15/h7,11,14-15,17-18H,4-6,8-10,12H2,1-3H3,(H2,25,32)(H,27,33)/t14-,15-,17-,18+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256231
PNG
(US9487483, 83)
Show SMILES CC[C@H]1CCC[C@H](C1)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2cc(C)ncc12
Show InChI InChI=1S/C24H32N6O3/c1-3-14-5-4-6-16(8-14)27-24(33)19-10-15-9-18(15)30(19)21(31)12-29-20-11-26-13(2)7-17(20)22(28-29)23(25)32/h7,11,14-16,18-19H,3-6,8-10,12H2,1-2H3,(H2,25,32)(H,27,33)/t14-,15+,16+,18+,19-/m0/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256154
PNG
(US9487483, 6)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC2CC(C)(C)CC(C)(C)C2)c2ncccc12
Show InChI InChI=1S/C26H35N5O3/c1-15(32)22-18-7-6-8-27-23(18)30(29-22)13-21(33)31-19-9-16(19)10-20(31)24(34)28-17-11-25(2,3)14-26(4,5)12-17/h6-8,16-17,19-20H,9-14H2,1-5H3,(H,28,34)/t16-,19-,20+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256202
PNG
(US9487483, 54)
Show SMILES CC1(C)CCC[C@H](C1)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccccc12
Show InChI InChI=1S/C24H31N5O3/c1-24(2)9-5-6-15(12-24)26-23(32)19-11-14-10-18(14)29(19)20(30)13-28-17-8-4-3-7-16(17)21(27-28)22(25)31/h3-4,7-8,14-15,18-19H,5-6,9-13H2,1-2H3,(H2,25,31)(H,26,32)/t14-,15-,18-,19+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256234
PNG
(US9487483, 86)
Show SMILES CC1(C)CCC[C@H](C1)NC(=O)[C@@H]1[C@@H]2C[C@@H]2CN1C(=O)Cn1nc(C(N)=O)c2ccncc12
Show InChI InChI=1S/C23H30N6O3/c1-23(2)6-3-4-14(9-23)26-22(32)20-16-8-13(16)11-28(20)18(30)12-29-17-10-25-7-5-15(17)19(27-29)21(24)31/h5,7,10,13-14,16,20H,3-4,6,8-9,11-12H2,1-2H3,(H2,24,31)(H,26,32)/t13-,14-,16-,20+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256232
PNG
(US9487483, 84)
Show SMILES CO[C@@H]1[C@@H](F)CN([C@@H]1C(=O)N[C@@H]1CCCC(C)(C)C1)C(=O)Cn1nc(C(N)=O)c2ccccc12
Show InChI InChI=1S/C24H32FN5O4/c1-24(2)10-6-7-14(11-24)27-23(33)20-21(34-3)16(25)12-29(20)18(31)13-30-17-9-5-4-8-15(17)19(28-30)22(26)32/h4-5,8-9,14,16,20-21H,6-7,10-13H2,1-3H3,(H2,26,32)(H,27,33)/t14-,16+,20+,21-/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256180
PNG
(US9487483, 32)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC2CCCC(C2)OC(F)(F)F)c2ccccc12
Show InChI InChI=1S/C24H27F3N4O4/c1-13(32)22-17-7-2-3-8-18(17)30(29-22)12-21(33)31-19-9-14(19)10-20(31)23(34)28-15-5-4-6-16(11-15)35-24(25,26)27/h2-3,7-8,14-16,19-20H,4-6,9-12H2,1H3,(H,28,34)/t14-,15?,16?,19-,20+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256275
PNG
(US9487483, 127)
Show SMILES C[C@]1(CO)CCC[C@H](C1)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccccc12
Show InChI InChI=1S/C24H31N5O4/c1-24(13-30)8-4-5-15(11-24)26-23(33)19-10-14-9-18(14)29(19)20(31)12-28-17-7-3-2-6-16(17)21(27-28)22(25)32/h2-3,6-7,14-15,18-19,30H,4-5,8-13H2,1H3,(H2,25,32)(H,26,33)/t14-,15-,18-,19+,24+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256184
PNG
(US9487483, 39)
Show SMILES CO[C@@]1(CCCC(C1)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccccc12)C(F)(F)F
Show InChI InChI=1S/C24H28F3N5O4/c1-36-23(24(25,26)27)8-4-5-14(11-23)29-22(35)18-10-13-9-17(13)32(18)19(33)12-31-16-7-3-2-6-15(16)20(30-31)21(28)34/h2-3,6-7,13-14,17-18H,4-5,8-12H2,1H3,(H2,28,34)(H,29,35)/t13-,14?,17-,18+,23-/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256261
PNG
(US9487483, 113)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@]3(CO)C[C@H]2C(=O)N[C@@H]2CCCC3(CC3)C2)c2cnccc12
Show InChI InChI=1S/C25H31N5O4/c1-15(32)22-17-4-8-26-12-19(17)29(28-22)13-21(33)30-18(10-25(14-31)11-20(25)30)23(34)27-16-3-2-5-24(9-16)6-7-24/h4,8,12,16,18,20,31H,2-3,5-7,9-11,13-14H2,1H3,(H,27,34)/t16-,18+,20-,25+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256244
PNG
(US9487483, 96)
Show SMILES C[C@H]1CCC[C@H](C1)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(C)=O)c2cc(OCc3ncccn3)ccc12
Show InChI InChI=1S/C29H34N6O4/c1-17-5-3-6-20(11-17)32-29(38)25-13-19-12-24(19)35(25)27(37)15-34-23-8-7-21(14-22(23)28(33-34)18(2)36)39-16-26-30-9-4-10-31-26/h4,7-10,14,17,19-20,24-25H,3,5-6,11-13,15-16H2,1-2H3,(H,32,38)/t17-,19+,20+,24+,25-/m0/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256195
PNG
(US9487483, 47)
Show SMILES C[C@H]1CCC[C@H](C1)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccccc12
Show InChI InChI=1S/C23H29N5O3/c1-13-5-4-6-15(9-13)25-23(31)19-11-14-10-18(14)28(19)20(29)12-27-17-8-3-2-7-16(17)21(26-27)22(24)30/h2-3,7-8,13-15,18-19H,4-6,9-12H2,1H3,(H2,24,30)(H,25,31)/t13-,14+,15+,18+,19-/m0/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256241
PNG
(US9487483, 93)
Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@H]2CCCC3(CC3)C2)c2ccccc12
Show InChI InChI=1S/C23H28FN5O3/c24-14-10-18(22(32)26-15-4-3-7-23(11-15)8-9-23)28(12-14)19(30)13-29-17-6-2-1-5-16(17)20(27-29)21(25)31/h1-2,5-6,14-15,18H,3-4,7-13H2,(H2,25,31)(H,26,32)/t14-,15+,18+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256238
PNG
(US9487483, 90)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@H]2CCCC(Cl)(Cl)C2)c2ccccc12
Show InChI InChI=1S/C23H26Cl2N4O3/c1-13(30)21-16-6-2-3-7-17(16)28(27-21)12-20(31)29-18-9-14(18)10-19(29)22(32)26-15-5-4-8-23(24,25)11-15/h2-3,6-7,14-15,18-19H,4-5,8-12H2,1H3,(H,26,32)/t14-,15+,18-,19+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256176
PNG
(US9487483, 28)
Show SMILES Cc1ccc2c(nn(CC(=O)N3[C@@H]4C[C@@H]4C[C@H]3C(=O)NC3CCCC(C)(C)C3)c2c1)C(N)=O
Show InChI InChI=1S/C25H33N5O3/c1-14-6-7-17-19(9-14)29(28-22(17)23(26)32)13-21(31)30-18-10-15(18)11-20(30)24(33)27-16-5-4-8-25(2,3)12-16/h6-7,9,15-16,18,20H,4-5,8,10-13H2,1-3H3,(H2,26,32)(H,27,33)/t15-,16?,18-,20+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256249
PNG
(US9487483, 101)
Show SMILES CO[C@H]1CC[C@H](C1)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(C)=O)c2cc(OCc3ncccn3)ccc12
Show InChI InChI=1S/C28H32N6O5/c1-16(35)27-21-13-20(39-15-25-29-8-3-9-30-25)6-7-22(21)33(32-27)14-26(36)34-23-10-17(23)11-24(34)28(37)31-18-4-5-19(12-18)38-2/h3,6-9,13,17-19,23-24H,4-5,10-12,14-15H2,1-2H3,(H,31,37)/t17-,18-,19+,23-,24+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256226
PNG
(US9487483, 78)
Show SMILES C[C@@H]1CC[C@H](C1)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccccc12
Show InChI InChI=1S/C22H27N5O3/c1-12-6-7-14(8-12)24-22(30)18-10-13-9-17(13)27(18)19(28)11-26-16-5-3-2-4-15(16)20(25-26)21(23)29/h2-5,12-14,17-18H,6-11H2,1H3,(H2,23,29)(H,24,30)/t12-,13-,14-,17-,18+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256189
PNG
(US9487483, 41)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@@H]2CCC[C@@H](C2)C(F)(F)F)c2cnccc12
Show InChI InChI=1S/C22H25F3N6O3/c23-22(24,25)12-2-1-3-13(8-12)28-21(34)16-7-11-6-15(11)31(16)18(32)10-30-17-9-27-5-4-14(17)19(29-30)20(26)33/h4-5,9,11-13,15-16H,1-3,6-8,10H2,(H2,26,33)(H,28,34)/t11-,12+,13-,15-,16+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256198
PNG
(US9487483, 50)
Show SMILES Cc1cc2c(nn(CC(=O)N3[C@@H]4C[C@@H]4C[C@H]3C(=O)N[C@@H]3CCC[C@@H](C3)C(F)(F)F)c2cn1)C(N)=O
Show InChI InChI=1S/C23H27F3N6O3/c1-11-5-15-18(9-28-11)31(30-20(15)21(27)34)10-19(33)32-16-6-12(16)7-17(32)22(35)29-14-4-2-3-13(8-14)23(24,25)26/h5,9,12-14,16-17H,2-4,6-8,10H2,1H3,(H2,27,34)(H,29,35)/t12-,13+,14-,16-,17+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256181
PNG
(US9487483, 33)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC2CCCC(C2)OC(F)(F)F)c2ccccc12
Show InChI InChI=1S/C23H26F3N5O4/c24-23(25,26)35-14-5-3-4-13(10-14)28-22(34)18-9-12-8-17(12)31(18)19(32)11-30-16-7-2-1-6-15(16)20(29-30)21(27)33/h1-2,6-7,12-14,17-18H,3-5,8-11H2,(H2,27,33)(H,28,34)/t12-,13?,14?,17-,18+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256222
PNG
(US9487483, 74)
Show SMILES CC1=CC(CCC1)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccccc12
Show InChI InChI=1S/C23H27N5O3/c1-13-5-4-6-15(9-13)25-23(31)19-11-14-10-18(14)28(19)20(29)12-27-17-8-3-2-7-16(17)21(26-27)22(24)30/h2-3,7-9,14-15,18-19H,4-6,10-12H2,1H3,(H2,24,30)(H,25,31)/t14-,15?,18-,19+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256242
PNG
(US9487483, 94)
Show SMILES CO[C@H]1CCC[C@H](C1)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(C)=O)c2cc(OCc3ncccn3)ccc12
Show InChI InChI=1S/C29H34N6O5/c1-17(36)28-22-14-21(40-16-26-30-9-4-10-31-26)7-8-23(22)34(33-28)15-27(37)35-24-11-18(24)12-25(35)29(38)32-19-5-3-6-20(13-19)39-2/h4,7-10,14,18-20,24-25H,3,5-6,11-13,15-16H2,1-2H3,(H,32,38)/t18-,19-,20+,24-,25+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256217
PNG
(US9487483, 69)
Show SMILES CO[C@@H]1CCC[C@H](C1)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(C)=O)c2cc(OCc3ncccn3)ccc12
Show InChI InChI=1S/C29H34N6O5/c1-17(36)28-22-14-21(40-16-26-30-9-4-10-31-26)7-8-23(22)34(33-28)15-27(37)35-24-11-18(24)12-25(35)29(38)32-19-5-3-6-20(13-19)39-2/h4,7-10,14,18-20,24-25H,3,5-6,11-13,15-16H2,1-2H3,(H,32,38)/t18-,19-,20-,24-,25+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256224
PNG
(US9487483, 76)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@H]2CCCC3(CC3)C2)c2cnccc12
Show InChI InChI=1S/C23H28N6O3/c24-21(31)20-15-3-7-25-11-18(15)28(27-20)12-19(30)29-16-8-13(16)9-17(29)22(32)26-14-2-1-4-23(10-14)5-6-23/h3,7,11,13-14,16-17H,1-2,4-6,8-10,12H2,(H2,24,31)(H,26,32)/t13-,14+,16-,17+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


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More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256267
PNG
(US9487483, 119)
Show SMILES CC[C@H]1CCC[C@@H](C1)NC(=O)[C@@H]1C[C@@]2(CO)C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccccc12
Show InChI InChI=1S/C25H33N5O4/c1-2-15-6-5-7-16(10-15)27-24(34)19-11-25(14-31)12-20(25)30(19)21(32)13-29-18-9-4-3-8-17(18)22(28-29)23(26)33/h3-4,8-9,15-16,19-20,31H,2,5-7,10-14H2,1H3,(H2,26,33)(H,27,34)/t15-,16-,19-,20+,25-/m0/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256274
PNG
(US9487483, 126)
Show SMILES COC1(C)CCCC(C1)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccccc12
Show InChI InChI=1S/C24H31N5O4/c1-24(33-2)9-5-6-15(12-24)26-23(32)19-11-14-10-18(14)29(19)20(30)13-28-17-8-4-3-7-16(17)21(27-28)22(25)31/h3-4,7-8,14-15,18-19H,5-6,9-13H2,1-2H3,(H2,25,31)(H,26,32)/t14-,15?,18-,19+,24?/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256149
PNG
(US9487483, 1)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC2CC(C)(C)C2)c2cnccc12
Show InChI InChI=1S/C22H27N5O3/c1-12(28)20-15-4-5-23-10-18(15)26(25-20)11-19(29)27-16-6-13(16)7-17(27)21(30)24-14-8-22(2,3)9-14/h4-5,10,13-14,16-17H,6-9,11H2,1-3H3,(H,24,30)/t13-,16-,17+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256253
PNG
(US9487483, 105)
Show SMILES CO[C@@H]1C[C@H](CC(C)(C)C1)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccccc12
Show InChI InChI=1S/C25H33N5O4/c1-25(2)11-15(10-16(12-25)34-3)27-24(33)20-9-14-8-19(14)30(20)21(31)13-29-18-7-5-4-6-17(18)22(28-29)23(26)32/h4-7,14-16,19-20H,8-13H2,1-3H3,(H2,26,32)(H,27,33)/t14-,15-,16-,19-,20+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256199
PNG
(US9487483, 51)
Show SMILES C[C@H]1CCC[C@H](C1)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccncc12
Show InChI InChI=1S/C22H28N6O3/c1-12-3-2-4-14(7-12)25-22(31)17-9-13-8-16(13)28(17)19(29)11-27-18-10-24-6-5-15(18)20(26-27)21(23)30/h5-6,10,12-14,16-17H,2-4,7-9,11H2,1H3,(H2,23,30)(H,25,31)/t12-,13+,14+,16+,17-/m0/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256250
PNG
(US9487483, 102)
Show SMILES CO[C@@H]1CC[C@@H](C1)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(C)=O)c2cc(OCc3ncccn3)ccc12
Show InChI InChI=1S/C28H32N6O5/c1-16(35)27-21-13-20(39-15-25-29-8-3-9-30-25)6-7-22(21)33(32-27)14-26(36)34-23-10-17(23)11-24(34)28(37)31-18-4-5-19(12-18)38-2/h3,6-9,13,17-19,23-24H,4-5,10-12,14-15H2,1-2H3,(H,31,37)/t17-,18+,19-,23-,24+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256225
PNG
(US9487483, 77)
Show SMILES C[C@H]1CC[C@H](C1)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccccc12
Show InChI InChI=1S/C22H27N5O3/c1-12-6-7-14(8-12)24-22(30)18-10-13-9-17(13)27(18)19(28)11-26-16-5-3-2-4-15(16)20(25-26)21(23)29/h2-5,12-14,17-18H,6-11H2,1H3,(H2,23,29)(H,24,30)/t12-,13+,14+,17+,18-/m0/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256252
PNG
(US9487483, 104)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC2CC(F)(F)C2)c2ccc(OCc3ncccn3)cc12
Show InChI InChI=1S/C26H26F2N6O4/c1-14(35)24-18-9-17(38-13-22-29-5-2-6-30-22)3-4-19(18)33(32-24)12-23(36)34-20-7-15(20)8-21(34)25(37)31-16-10-26(27,28)11-16/h2-6,9,15-16,20-21H,7-8,10-13H2,1H3,(H,31,37)/t15-,20-,21+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256185
PNG
(US9487483, 38)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC2CCCC=C2F)c2ccc(OCc3ncccn3)cc12
Show InChI InChI=1S/C28H29FN6O4/c1-16(36)27-19-13-18(39-15-25-30-9-4-10-31-25)7-8-22(19)34(33-27)14-26(37)35-23-11-17(23)12-24(35)28(38)32-21-6-3-2-5-20(21)29/h4-5,7-10,13,17,21,23-24H,2-3,6,11-12,14-15H2,1H3,(H,32,38)/t17-,21?,23-,24+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256215
PNG
(US9487483, 67)
Show SMILES CC1(C)CC[C@H](C1)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccncc12
Show InChI InChI=1S/C22H28N6O3/c1-22(2)5-3-13(9-22)25-21(31)16-8-12-7-15(12)28(16)18(29)11-27-17-10-24-6-4-14(17)19(26-27)20(23)30/h4,6,10,12-13,15-16H,3,5,7-9,11H2,1-2H3,(H2,23,30)(H,25,31)/t12-,13-,15-,16+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256191
PNG
(US9487483, 43)
Show SMILES CO[C@@H]1CCC[C@H](C1)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(C)=O)c2ccccc12
Show InChI InChI=1S/C24H30N4O4/c1-14(29)23-18-8-3-4-9-19(18)27(26-23)13-22(30)28-20-10-15(20)11-21(28)24(31)25-16-6-5-7-17(12-16)32-2/h3-4,8-9,15-17,20-21H,5-7,10-13H2,1-2H3,(H,25,31)/t15-,16-,17-,20-,21+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256245
PNG
(US9487483, 97)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@H]2CCCC(C)(C)C2)c2ccc(OCc3ncccn3)cc12
Show InChI InChI=1S/C30H36N6O4/c1-18(37)28-22-14-21(40-17-26-31-10-5-11-32-26)7-8-23(22)35(34-28)16-27(38)36-24-12-19(24)13-25(36)29(39)33-20-6-4-9-30(2,3)15-20/h5,7-8,10-11,14,19-20,24-25H,4,6,9,12-13,15-17H2,1-3H3,(H,33,39)/t19-,20+,24-,25+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256260
PNG
(US9487483, 112)
Show SMILES CC1(C)CCC[C@@H](C1)NC(=O)[C@@H]1C[C@@]2(CO)C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccccc12
Show InChI InChI=1S/C25H33N5O4/c1-24(2)9-5-6-15(10-24)27-23(34)18-11-25(14-31)12-19(25)30(18)20(32)13-29-17-8-4-3-7-16(17)21(28-29)22(26)33/h3-4,7-8,15,18-19,31H,5-6,9-14H2,1-2H3,(H2,26,33)(H,27,34)/t15-,18-,19+,25-/m0/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256172
PNG
(US9487483, 24)
Show SMILES CC[C@@H]1CCC[C@@H](C1)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Nc1cn(C(N)=O)c2ccccc12
Show InChI InChI=1S/C24H31N5O3/c1-2-14-6-5-7-16(10-14)26-22(30)21-12-15-11-20(15)29(21)24(32)27-18-13-28(23(25)31)19-9-4-3-8-17(18)19/h3-4,8-9,13-16,20-21H,2,5-7,10-12H2,1H3,(H2,25,31)(H,26,30)(H,27,32)/t14-,15-,16+,20-,21+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256266
PNG
(US9487483, 118)
Show SMILES CC[C@@H]1CCC[C@H](C1)NC(=O)[C@@H]1C[C@@]2(CO)C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccccc12
Show InChI InChI=1S/C25H33N5O4/c1-2-15-6-5-7-16(10-15)27-24(34)19-11-25(14-31)12-20(25)30(19)21(32)13-29-18-9-4-3-8-17(18)22(28-29)23(26)33/h3-4,8-9,15-16,19-20,31H,2,5-7,10-14H2,1H3,(H2,26,33)(H,27,34)/t15-,16-,19+,20-,25+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256193
PNG
(US9487483, 45)
Show SMILES CO[C@H]1CCC[C@H](C1)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(C)=O)c2ccccc12
Show InChI InChI=1S/C24H30N4O4/c1-14(29)23-18-8-3-4-9-19(18)27(26-23)13-22(30)28-20-10-15(20)11-21(28)24(31)25-16-6-5-7-17(12-16)32-2/h3-4,8-9,15-17,20-21H,5-7,10-13H2,1-2H3,(H,25,31)/t15-,16-,17+,20-,21+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256247
PNG
(US9487483, 99)
Show SMILES CO[C@@H]1CC[C@H](C1)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(C)=O)c2cc(OCc3ncccn3)ccc12
Show InChI InChI=1S/C28H32N6O5/c1-16(35)27-21-13-20(39-15-25-29-8-3-9-30-25)6-7-22(21)33(32-27)14-26(36)34-23-10-17(23)11-24(34)28(37)31-18-4-5-19(12-18)38-2/h3,6-9,13,17-19,23-24H,4-5,10-12,14-15H2,1-2H3,(H,31,37)/t17-,18-,19-,23-,24+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256255
PNG
(US9487483, 107)
Show SMILES COC1CC(CC(C)(C)C1)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccccc12
Show InChI InChI=1S/C25H33N5O4/c1-25(2)11-15(10-16(12-25)34-3)27-24(33)20-9-14-8-19(14)30(20)21(31)13-29-18-7-5-4-6-17(18)22(28-29)23(26)32/h4-7,14-16,19-20H,8-13H2,1-3H3,(H2,26,32)(H,27,33)/t14-,15?,16?,19-,20+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256228
PNG
(US9487483, 80)
Show SMILES C[C@@H]1CC[C@@H](C1)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccccc12
Show InChI InChI=1S/C22H27N5O3/c1-12-6-7-14(8-12)24-22(30)18-10-13-9-17(13)27(18)19(28)11-26-16-5-3-2-4-15(16)20(25-26)21(23)29/h2-5,12-14,17-18H,6-11H2,1H3,(H2,23,29)(H,24,30)/t12-,13-,14+,17-,18+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256194
PNG
(US9487483, 46)
Show SMILES CO[C@H]1CCC[C@H](C1)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccccc12
Show InChI InChI=1S/C23H29N5O4/c1-32-15-6-4-5-14(11-15)25-23(31)19-10-13-9-18(13)28(19)20(29)12-27-17-8-3-2-7-16(17)21(26-27)22(24)30/h2-3,7-8,13-15,18-19H,4-6,9-12H2,1H3,(H2,24,30)(H,25,31)/t13-,14-,15+,18-,19+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


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More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256169
PNG
(US9487483, 21)
Show SMILES CO[C@H]1CCC[C@H](C1)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Nc1cn(C(N)=O)c2ccccc12
Show InChI InChI=1S/C23H29N5O4/c1-32-15-6-4-5-14(11-15)25-21(29)20-10-13-9-19(13)28(20)23(31)26-17-12-27(22(24)30)18-8-3-2-7-16(17)18/h2-3,7-8,12-15,19-20H,4-6,9-11H2,1H3,(H2,24,30)(H,25,29)(H,26,31)/t13-,14-,15+,19-,20+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256233
PNG
(US9487483, 85)
Show SMILES CO[C@@H]1[C@@H](F)CN([C@@H]1C(=O)N[C@H]1CCCC(C)(C)C1)C(=O)Cn1nc(C(N)=O)c2ccccc12
Show InChI InChI=1S/C24H32FN5O4/c1-24(2)10-6-7-14(11-24)27-23(33)20-21(34-3)16(25)12-29(20)18(31)13-30-17-9-5-4-8-15(17)19(28-30)22(26)32/h4-5,8-9,14,16,20-21H,6-7,10-13H2,1-3H3,(H2,26,32)(H,27,33)/t14-,16-,20-,21+/m0/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256165
PNG
(US9487483, 17)
Show SMILES NC(=O)n1cc(NC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@@H]2CCC[C@@H](C2)OCC(F)(F)F)c2ccccc12
Show InChI InChI=1S/C24H28F3N5O4/c25-24(26,27)12-36-15-5-3-4-14(10-15)29-21(33)20-9-13-8-19(13)32(20)23(35)30-17-11-31(22(28)34)18-7-2-1-6-16(17)18/h1-2,6-7,11,13-15,19-20H,3-5,8-10,12H2,(H2,28,34)(H,29,33)(H,30,35)/t13-,14-,15+,19-,20+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256182
PNG
(US9487483, 34)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC2CCCC(O)(C2)C(F)(F)F)c2cnccc12
Show InChI InChI=1S/C22H25F3N6O4/c23-22(24,25)21(35)4-1-2-12(8-21)28-20(34)15-7-11-6-14(11)31(15)17(32)10-30-16-9-27-5-3-13(16)18(29-30)19(26)33/h3,5,9,11-12,14-15,35H,1-2,4,6-8,10H2,(H2,26,33)(H,28,34)/t11-,12?,14-,15+,21?/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256186
PNG
(US9487483, 36)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@H]2CCCCC2(F)F)c2ccc(OCc3ncccn3)cc12
Show InChI InChI=1S/C28H30F2N6O4/c1-16(37)26-19-13-18(40-15-24-31-9-4-10-32-24)6-7-20(19)35(34-26)14-25(38)36-21-11-17(21)12-22(36)27(39)33-23-5-2-3-8-28(23,29)30/h4,6-7,9-10,13,17,21-23H,2-3,5,8,11-12,14-15H2,1H3,(H,33,39)/t17-,21-,22+,23+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256183
PNG
(US9487483, 35)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC2CCCCC2(F)F)c2cnccc12
Show InChI InChI=1S/C21H24F2N6O3/c22-21(23)5-2-1-3-16(21)26-20(32)14-8-11-7-13(11)29(14)17(30)10-28-15-9-25-6-4-12(15)18(27-28)19(24)31/h4,6,9,11,13-14,16H,1-3,5,7-8,10H2,(H2,24,31)(H,26,32)/t11-,13-,14+,16?/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256167
PNG
(US9487483, 19)
Show SMILES NC(=O)n1cc(NC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@H]2CCC[C@@H](C2)OCC(F)(F)F)c2ccccc12
Show InChI InChI=1S/C24H28F3N5O4/c25-24(26,27)12-36-15-5-3-4-14(10-15)29-21(33)20-9-13-8-19(13)32(20)23(35)30-17-11-31(22(28)34)18-7-2-1-6-16(17)18/h1-2,6-7,11,13-15,19-20H,3-5,8-10,12H2,(H2,28,34)(H,29,33)(H,30,35)/t13-,14+,15+,19-,20+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256179
PNG
(US9487483, 31)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC2CCCC(O)(C2)C(F)(F)F)c2ccccc12
Show InChI InChI=1S/C23H26F3N5O4/c24-23(25,26)22(35)7-3-4-13(10-22)28-21(34)17-9-12-8-16(12)31(17)18(32)11-30-15-6-2-1-5-14(15)19(29-30)20(27)33/h1-2,5-6,12-13,16-17,35H,3-4,7-11H2,(H2,27,33)(H,28,34)/t12-,13?,16-,17+,22?/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256201
PNG
(US9487483, 53)
Show SMILES CC1(C)CCC[C@@H](C1)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccccc12
Show InChI InChI=1S/C24H31N5O3/c1-24(2)9-5-6-15(12-24)26-23(32)19-11-14-10-18(14)29(19)20(30)13-28-17-8-4-3-7-16(17)21(27-28)22(25)31/h3-4,7-8,14-15,18-19H,5-6,9-13H2,1-2H3,(H2,25,31)(H,26,32)/t14-,15+,18-,19+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256271
PNG
(US9487483, 123)
Show SMILES CC1(O)CCCC(C1)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccccc12
Show InChI InChI=1S/C23H29N5O4/c1-23(32)8-4-5-14(11-23)25-22(31)18-10-13-9-17(13)28(18)19(29)12-27-16-7-3-2-6-15(16)20(26-27)21(24)30/h2-3,6-7,13-14,17-18,32H,4-5,8-12H2,1H3,(H2,24,30)(H,25,31)/t13-,14?,17-,18+,23?/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256248
PNG
(US9487483, 100)
Show SMILES CO[C@H]1CC[C@@H](C1)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(C)=O)c2cc(OCc3ncccn3)ccc12
Show InChI InChI=1S/C28H32N6O5/c1-16(35)27-21-13-20(39-15-25-29-8-3-9-30-25)6-7-22(21)33(32-27)14-26(36)34-23-10-17(23)11-24(34)28(37)31-18-4-5-19(12-18)38-2/h3,6-9,13,17-19,23-24H,4-5,10-12,14-15H2,1-2H3,(H,31,37)/t17-,18+,19+,23-,24+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256268
PNG
(US9487483, 120)
Show SMILES CC[C@@H]1CCC[C@@H](C1)NC(=O)[C@@H]1C[C@@]2(CO)C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccccc12
Show InChI InChI=1S/C25H33N5O4/c1-2-15-6-5-7-16(10-15)27-24(34)19-11-25(14-31)12-20(25)30(19)21(32)13-29-18-9-4-3-8-17(18)22(28-29)23(26)33/h3-4,8-9,15-16,19-20,31H,2,5-7,10-14H2,1H3,(H2,26,33)(H,27,34)/t15-,16+,19+,20-,25+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256200
PNG
(US9487483, 52)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC2CCC(F)(F)C2)c2ccccc12
Show InChI InChI=1S/C21H23F2N5O3/c22-21(23)6-5-12(9-21)25-20(31)16-8-11-7-15(11)28(16)17(29)10-27-14-4-2-1-3-13(14)18(26-27)19(24)30/h1-4,11-12,15-16H,5-10H2,(H2,24,30)(H,25,31)/t11-,12?,15-,16+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256190
PNG
(US9487483, 42)
Show SMILES CO[C@H]1CCC[C@@H](C1)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(C)=O)c2ccccc12
Show InChI InChI=1S/C24H30N4O4/c1-14(29)23-18-8-3-4-9-19(18)27(26-23)13-22(30)28-20-10-15(20)11-21(28)24(31)25-16-6-5-7-17(12-16)32-2/h3-4,8-9,15-17,20-21H,5-7,10-13H2,1-2H3,(H,25,31)/t15-,16+,17+,20-,21+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256273
PNG
(US9487483, 125)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@@H]2C[C@@H](O)CC(C)(C)C2)c2ccccc12
Show InChI InChI=1S/C25H32N4O4/c1-14(30)23-18-6-4-5-7-19(18)28(27-23)13-22(32)29-20-8-15(20)9-21(29)24(33)26-16-10-17(31)12-25(2,3)11-16/h4-7,15-17,20-21,31H,8-13H2,1-3H3,(H,26,33)/t15-,16-,17-,20-,21+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256214
PNG
(US9487483, 66)
Show SMILES CC(=O)c1cn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@@H]2CCCC(C)(C)C2)c2nnccc12
Show InChI InChI=1S/C24H31N5O3/c1-14(30)18-12-28(22-17(18)6-8-25-27-22)13-21(31)29-19-9-15(19)10-20(29)23(32)26-16-5-4-7-24(2,3)11-16/h6,8,12,15-16,19-20H,4-5,7,9-11,13H2,1-3H3,(H,26,32)/t15-,16-,19-,20+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256168
PNG
(US9487483, 20)
Show SMILES NC(=O)n1cc(NC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@H]2CCC[C@H](C2)OCC(F)(F)F)c2ccccc12
Show InChI InChI=1S/C24H28F3N5O4/c25-24(26,27)12-36-15-5-3-4-14(10-15)29-21(33)20-9-13-8-19(13)32(20)23(35)30-17-11-31(22(28)34)18-7-2-1-6-16(17)18/h1-2,6-7,11,13-15,19-20H,3-5,8-10,12H2,(H2,28,34)(H,29,33)(H,30,35)/t13-,14+,15-,19-,20+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256262
PNG
(US9487483, 114)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@]3(CO)C[C@H]2C(=O)N[C@H]2CCCC3(CC3)C2)c2cnccc12
Show InChI InChI=1S/C25H31N5O4/c1-15(32)22-17-4-8-26-12-19(17)29(28-22)13-21(33)30-18(10-25(14-31)11-20(25)30)23(34)27-16-3-2-5-24(9-16)6-7-24/h4,8,12,16,18,20,31H,2-3,5-7,9-11,13-14H2,1H3,(H,27,34)/t16-,18-,20+,25-/m0/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256196
PNG
(US9487483, 48)
Show SMILES C[C@@H]1CCC[C@@H](C1)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccccc12
Show InChI InChI=1S/C23H29N5O3/c1-13-5-4-6-15(9-13)25-23(31)19-11-14-10-18(14)28(19)20(29)12-27-17-8-3-2-7-16(17)21(26-27)22(24)30/h2-3,7-8,13-15,18-19H,4-6,9-12H2,1H3,(H2,24,30)(H,25,31)/t13-,14-,15+,18-,19+/m1/s1
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Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256157
PNG
(US9487483, 9)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC2CCCC(F)(F)C2)c2cnccc12
Show InChI InChI=1S/C22H25F2N5O3/c1-12(30)20-15-4-6-25-10-18(15)28(27-20)11-19(31)29-16-7-13(16)8-17(29)21(32)26-14-3-2-5-22(23,24)9-14/h4,6,10,13-14,16-17H,2-3,5,7-9,11H2,1H3,(H,26,32)/t13-,14?,16-,17+/m1/s1
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n/an/a 1.48E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256223
PNG
(US9487483, 75)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@@H]2CCCC3(CC3)C2)c2cnccc12
Show InChI InChI=1S/C23H28N6O3/c24-21(31)20-15-3-7-25-11-18(15)28(27-20)12-19(30)29-16-8-13(16)9-17(29)22(32)26-14-2-1-4-23(10-14)5-6-23/h3,7,11,13-14,16-17H,1-2,4-6,8-10,12H2,(H2,24,31)(H,26,32)/t13-,14-,16-,17+/m1/s1
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n/an/a 1.57E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256264
PNG
(US9487483, 116)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@]3(CO)C[C@H]2C(=O)N[C@H]2CCCC(C)(C)C2)c2ncccc12
Show InChI InChI=1S/C25H33N5O4/c1-15(32)21-17-7-5-9-26-22(17)29(28-21)13-20(33)30-18(11-25(14-31)12-19(25)30)23(34)27-16-6-4-8-24(2,3)10-16/h5,7,9,16,18-19,31H,4,6,8,10-14H2,1-3H3,(H,27,34)/t16-,18-,19+,25-/m0/s1
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n/an/a 1.60E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256155
PNG
(US9487483, 7)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC2CCOC(C)(C)C2)c2cnccc12
Show InChI InChI=1S/C23H29N5O4/c1-13(29)21-16-4-6-24-11-19(16)27(26-21)12-20(30)28-17-8-14(17)9-18(28)22(31)25-15-5-7-32-23(2,3)10-15/h4,6,11,14-15,17-18H,5,7-10,12H2,1-3H3,(H,25,31)/t14-,15?,17-,18+/m1/s1
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n/an/a 1.68E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256166
PNG
(US9487483, 18)
Show SMILES NC(=O)n1cc(NC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@@H]2CCC[C@H](C2)OCC(F)(F)F)c2ccccc12
Show InChI InChI=1S/C24H28F3N5O4/c25-24(26,27)12-36-15-5-3-4-14(10-15)29-21(33)20-9-13-8-19(13)32(20)23(35)30-17-11-31(22(28)34)18-7-2-1-6-16(17)18/h1-2,6-7,11,13-15,19-20H,3-5,8-10,12H2,(H2,28,34)(H,29,33)(H,30,35)/t13-,14-,15-,19-,20+/m1/s1
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Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256220
PNG
(US9487483, 72)
Show SMILES CC[C@@H]1CCC[C@@H](C1)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccncc12
Show InChI InChI=1S/C23H30N6O3/c1-2-13-4-3-5-15(8-13)26-23(32)18-10-14-9-17(14)29(18)20(30)12-28-19-11-25-7-6-16(19)21(27-28)22(24)31/h6-7,11,13-15,17-18H,2-5,8-10,12H2,1H3,(H2,24,31)(H,26,32)/t13-,14-,15+,17-,18+/m1/s1
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Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256163
PNG
(US9487483, 15)
Show SMILES NC(=O)n1cc(NC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC2CCCCC2)c2ccccc12
Show InChI InChI=1S/C22H27N5O3/c23-21(29)26-12-16(15-8-4-5-9-17(15)26)25-22(30)27-18-10-13(18)11-19(27)20(28)24-14-6-2-1-3-7-14/h4-5,8-9,12-14,18-19H,1-3,6-7,10-11H2,(H2,23,29)(H,24,28)(H,25,30)/t13-,18-,19+/m1/s1
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Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256158
PNG
(US9487483, 10)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC2(CO)CCCCC2)c2cnccc12
Show InChI InChI=1S/C23H29N5O4/c1-14(30)21-16-5-8-24-11-19(16)27(26-21)12-20(31)28-17-9-15(17)10-18(28)22(32)25-23(13-29)6-3-2-4-7-23/h5,8,11,15,17-18,29H,2-4,6-7,9-10,12-13H2,1H3,(H,25,32)/t15-,17-,18+/m1/s1
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Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256192
PNG
(US9487483, 44)
Show SMILES CO[C@@H]1CCC[C@@H](C1)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(C)=O)c2ccccc12
Show InChI InChI=1S/C24H30N4O4/c1-14(29)23-18-8-3-4-9-19(18)27(26-23)13-22(30)28-20-10-15(20)11-21(28)24(31)25-16-6-5-7-17(12-16)32-2/h3-4,8-9,15-17,20-21H,5-7,10-13H2,1-2H3,(H,25,31)/t15-,16+,17-,20-,21+/m1/s1
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Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256216
PNG
(US9487483, 68)
Show SMILES CC1(C)CC[C@@H](C1)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccncc12
Show InChI InChI=1S/C22H28N6O3/c1-22(2)5-3-13(9-22)25-21(31)16-8-12-7-15(12)28(16)18(29)11-27-17-10-24-6-4-14(17)19(26-27)20(23)30/h4,6,10,12-13,15-16H,3,5,7-9,11H2,1-2H3,(H2,23,30)(H,25,31)/t12-,13+,15-,16+/m1/s1
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Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256205
PNG
(US9487483, 57)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@@H]2CCCC3(CC3)C2)c2ccccc12
Show InChI InChI=1S/C24H29N5O3/c25-22(31)21-16-5-1-2-6-17(16)28(27-21)13-20(30)29-18-10-14(18)11-19(29)23(32)26-15-4-3-7-24(12-15)8-9-24/h1-2,5-6,14-15,18-19H,3-4,7-13H2,(H2,25,31)(H,26,32)/t14-,15-,18-,19+/m1/s1
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Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256240
PNG
(US9487483, 92)
Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H]2CCCC3(CC3)C2)c2ccccc12
Show InChI InChI=1S/C23H28FN5O3/c24-14-10-18(22(32)26-15-4-3-7-23(11-15)8-9-23)28(12-14)19(30)13-29-17-6-2-1-5-16(17)20(27-29)21(25)31/h1-2,5-6,14-15,18H,3-4,7-13H2,(H2,25,31)(H,26,32)/t14-,15-,18+/m1/s1
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Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256218
PNG
(US9487483, 70)
Show SMILES CC1(C)CCC[C@@H](C1)NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1nc(C(N)=O)c2ccncc12
Show InChI InChI=1S/C22H29FN6O3/c1-22(2)6-3-4-14(9-22)26-21(32)16-8-13(23)11-28(16)18(30)12-29-17-10-25-7-5-15(17)19(27-29)20(24)31/h5,7,10,13-14,16H,3-4,6,8-9,11-12H2,1-2H3,(H2,24,31)(H,26,32)/t13-,14+,16+/m1/s1
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Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256237
PNG
(US9487483, 89)
Show SMILES CC1(C)CCC[C@@H](C1)NC(=O)[C@@H]1[C@@H]2C[C@@H]2CN1C(=O)Cn1nc(C(N)=O)c2ccccc12
Show InChI InChI=1S/C24H31N5O3/c1-24(2)9-5-6-15(11-24)26-23(32)21-17-10-14(17)12-28(21)19(30)13-29-18-8-4-3-7-16(18)20(27-29)22(25)31/h3-4,7-8,14-15,17,21H,5-6,9-13H2,1-2H3,(H2,25,31)(H,26,32)/t14-,15+,17-,21+/m1/s1
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Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256270
PNG
(US9487483, 122)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@]3(CO)C[C@H]2C(=O)N[C@H]2CCCC(C)(C)C2)c2cnccc12
Show InChI InChI=1S/C25H33N5O4/c1-15(32)22-17-6-8-26-12-19(17)29(28-22)13-21(33)30-18(10-25(14-31)11-20(25)30)23(34)27-16-5-4-7-24(2,3)9-16/h6,8,12,16,18,20,31H,4-5,7,9-11,13-14H2,1-3H3,(H,27,34)/t16-,18-,20+,25-/m0/s1
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Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256276
PNG
(US9487483, 128)
Show SMILES C[C@@]1(CO)CCC[C@@H](C1)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccccc12
Show InChI InChI=1S/C24H31N5O4/c1-24(13-30)8-4-5-15(11-24)26-23(33)19-10-14-9-18(14)29(19)20(31)12-28-17-7-3-2-6-16(17)21(27-28)22(25)32/h2-3,6-7,14-15,18-19,30H,4-5,8-13H2,1H3,(H2,25,32)(H,26,33)/t14-,15+,18-,19+,24-/m1/s1
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Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256203
PNG
(US9487483, 55)
Show SMILES CC1(C)CCC[C@@H](C1)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccncc12
Show InChI InChI=1S/C23H30N6O3/c1-23(2)6-3-4-14(10-23)26-22(32)17-9-13-8-16(13)29(17)19(30)12-28-18-11-25-7-5-15(18)20(27-28)21(24)31/h5,7,11,13-14,16-17H,3-4,6,8-10,12H2,1-2H3,(H2,24,31)(H,26,32)/t13-,14+,16-,17+/m1/s1
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Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256256
PNG
(US9487483, 108)
Show SMILES CC1(C)C[C@H](O)C[C@H](C1)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccccc12
Show InChI InChI=1S/C24H31N5O4/c1-24(2)10-14(9-15(30)11-24)26-23(33)19-8-13-7-18(13)29(19)20(31)12-28-17-6-4-3-5-16(17)21(27-28)22(25)32/h3-6,13-15,18-19,30H,7-12H2,1-2H3,(H2,25,32)(H,26,33)/t13-,14-,15-,18-,19+/m1/s1
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US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256156
PNG
(US9487483, 8)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC2CC(F)(F)C2)c2cnccc12
Show InChI InChI=1S/C20H21F2N5O3/c1-10(28)18-13-2-3-23-8-16(13)26(25-18)9-17(29)27-14-4-11(14)5-15(27)19(30)24-12-6-20(21,22)7-12/h2-3,8,11-12,14-15H,4-7,9H2,1H3,(H,24,30)/t11-,14-,15+/m1/s1
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US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256227
PNG
(US9487483, 79)
Show SMILES C[C@H]1CC[C@@H](C1)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccccc12
Show InChI InChI=1S/C22H27N5O3/c1-12-6-7-14(8-12)24-22(30)18-10-13-9-17(13)27(18)19(28)11-26-16-5-3-2-4-15(16)20(25-26)21(23)29/h2-5,12-14,17-18H,6-11H2,1H3,(H2,23,29)(H,24,30)/t12-,13+,14-,17+,18-/m0/s1
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US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256162
PNG
(US9487483, 14)
Show SMILES COC(=O)[C@@H]1CCC[C@@H](C1)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(C)=O)c2cccnc12
Show InChI InChI=1S/C24H29N5O5/c1-13(30)21-17-7-4-8-25-22(17)28(27-21)12-20(31)29-18-10-15(18)11-19(29)23(32)26-16-6-3-5-14(9-16)24(33)34-2/h4,7-8,14-16,18-19H,3,5-6,9-12H2,1-2H3,(H,26,32)/t14-,15-,16+,18-,19+/m1/s1
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US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


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More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256159
PNG
(US9487483, 11)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC2CCC(F)(F)CC2)c2cnccc12
Show InChI InChI=1S/C22H25F2N5O3/c1-12(30)20-15-4-7-25-10-18(15)28(27-20)11-19(31)29-16-8-13(16)9-17(29)21(32)26-14-2-5-22(23,24)6-3-14/h4,7,10,13-14,16-17H,2-3,5-6,8-9,11H2,1H3,(H,26,32)/t13-,16-,17+/m1/s1
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US Patent
n/an/a 3.02E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256164
PNG
(US9487483, 16)
Show SMILES NC(=O)n1cc(NC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@H]2CCCC=C2)c2ccccc12
Show InChI InChI=1S/C22H25N5O3/c23-21(29)26-12-16(15-8-4-5-9-17(15)26)25-22(30)27-18-10-13(18)11-19(27)20(28)24-14-6-2-1-3-7-14/h2,4-6,8-9,12-14,18-19H,1,3,7,10-11H2,(H2,23,29)(H,24,28)(H,25,30)/t13-,14-,18-,19+/m1/s1
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US Patent
n/an/a 3.15E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256188
PNG
(US9487483, 40)
Show SMILES CO[C@@]1(CCCC(C1)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccccc12)C(F)(F)F
Show InChI InChI=1S/C24H28F3N5O4/c1-36-23(24(25,26)27)8-4-5-14(11-23)29-22(35)18-10-13-9-17(13)32(18)19(33)12-31-16-7-3-2-6-15(16)20(30-31)21(28)34/h2-3,6-7,13-14,17-18H,4-5,8-12H2,1H3,(H2,28,34)(H,29,35)/t13-,14?,17-,18+,23-/m1/s1
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n/an/a 4.47E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256151
PNG
(US9487483, 3)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC2CC2(F)F)c2ncccc12
Show InChI InChI=1S/C19H19F2N5O3/c1-9(27)16-11-3-2-4-22-17(11)25(24-16)8-15(28)26-12-5-10(12)6-13(26)18(29)23-14-7-19(14,20)21/h2-4,10,12-14H,5-8H2,1H3,(H,23,29)/t10-,12-,13+,14?/m1/s1
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n/an/a 4.79E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256152
PNG
(US9487483, 4)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@@H]2C[C@@H]2F)c2ncccc12
Show InChI InChI=1S/C19H20FN5O3/c1-9(26)17-11-3-2-4-21-18(11)24(23-17)8-16(27)25-14-5-10(14)6-15(25)19(28)22-13-7-12(13)20/h2-4,10,12-15H,5-8H2,1H3,(H,22,28)/t10-,12+,13-,14-,15+/m1/s1
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n/an/a 5.13E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256161
PNG
(US9487483, 13)
Show SMILES COC(=O)[C@@H]1CC[C@H](C1)NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(C)=O)c2cccnc12
Show InChI InChI=1S/C23H27N5O5/c1-12(29)20-16-4-3-7-24-21(16)27(26-20)11-19(30)28-17-9-14(17)10-18(28)22(31)25-15-6-5-13(8-15)23(32)33-2/h3-4,7,13-15,17-18H,5-6,8-11H2,1-2H3,(H,25,31)/t13-,14-,15-,17-,18+/m1/s1
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n/an/a 5.97E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256235
PNG
(US9487483, 87)
Show SMILES CC1(C)CCC[C@@H](C1)NC(=O)[C@@H]1[C@@H]2C[C@@H]2CN1C(=O)Cn1nc(C(N)=O)c2ccncc12
Show InChI InChI=1S/C23H30N6O3/c1-23(2)6-3-4-14(9-23)26-22(32)20-16-8-13(16)11-28(20)18(30)12-29-17-10-25-7-5-15(17)19(27-29)21(24)31/h5,7,10,13-14,16,20H,3-4,6,8-9,11-12H2,1-2H3,(H2,24,31)(H,26,32)/t13-,14+,16-,20+/m1/s1
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n/an/a 6.62E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256150
PNG
(US9487483, 2)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC2CC2(C)C)c2ncccc12
Show InChI InChI=1S/C21H25N5O3/c1-11(27)18-13-5-4-6-22-19(13)25(24-18)10-17(28)26-14-7-12(14)8-15(26)20(29)23-16-9-21(16,2)3/h4-6,12,14-16H,7-10H2,1-3H3,(H,23,29)/t12-,14-,15+,16?/m1/s1
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n/an/a 6.90E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM256160
PNG
(US9487483, 12)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@@H]2CC[C@H](C2)C(N)=O)c2ncccc12
Show InChI InChI=1S/C22H26N6O4/c1-11(29)19-15-3-2-6-24-21(15)27(26-19)10-18(30)28-16-8-13(16)9-17(28)22(32)25-14-5-4-12(7-14)20(23)31/h2-3,6,12-14,16-17H,4-5,7-10H2,1H3,(H2,23,31)(H,25,32)/t12-,13-,14-,16-,17+/m1/s1
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n/an/a 1.27E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%