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Patent code US9487501

Compile Data Set for Download or QSAR
Found 114 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256431
PNG
(US9487501, 32)
Show SMILES Cc1nn(cc1C(=O)Nc1ccc(cc1)[C@H]1CNCCO1)-c1ccc(OC(F)F)cc1
Show InChI InChI=1S/C22H22F2N4O3/c1-14-19(13-28(27-14)17-6-8-18(9-7-17)31-22(23)24)21(29)26-16-4-2-15(3-5-16)20-12-25-10-11-30-20/h2-9,13,20,22,25H,10-12H2,1H3,(H,26,29)/t20-/m1/s1
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0.200n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256425
PNG
(US9487501, 26)
Show SMILES FC(F)(F)Oc1ccc(cc1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C21H19F3N4O3/c22-21(23,24)31-18-7-5-17(6-8-18)28-13-15(11-26-28)20(29)27-16-3-1-14(2-4-16)19-12-25-9-10-30-19/h1-8,11,13,19,25H,9-10,12H2,(H,27,29)/t19-/m1/s1
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0.5n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256403
PNG
(US9487501, 4)
Show SMILES Fc1ccc(cc1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C20H19FN4O2/c21-16-3-7-18(8-4-16)25-13-15(11-23-25)20(26)24-17-5-1-14(2-6-17)19-12-22-9-10-27-19/h1-8,11,13,19,22H,9-10,12H2,(H,24,26)/t19-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256425
PNG
(US9487501, 26)
Show SMILES FC(F)(F)Oc1ccc(cc1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C21H19F3N4O3/c22-21(23,24)31-18-7-5-17(6-8-18)28-13-15(11-26-28)20(29)27-16-3-1-14(2-4-16)19-12-25-9-10-30-19/h1-8,11,13,19,25H,9-10,12H2,(H,27,29)/t19-/m1/s1
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0.700n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256431
PNG
(US9487501, 32)
Show SMILES Cc1nn(cc1C(=O)Nc1ccc(cc1)[C@H]1CNCCO1)-c1ccc(OC(F)F)cc1
Show InChI InChI=1S/C22H22F2N4O3/c1-14-19(13-28(27-14)17-6-8-18(9-7-17)31-22(23)24)21(29)26-16-4-2-15(3-5-16)20-12-25-10-11-30-20/h2-9,13,20,22,25H,10-12H2,1H3,(H,26,29)/t20-/m1/s1
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0.800n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256427
PNG
(US9487501, 28)
Show SMILES CCOc1cccc(n1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C21H23N5O3/c1-2-28-20-5-3-4-19(25-20)26-14-16(12-23-26)21(27)24-17-8-6-15(7-9-17)18-13-22-10-11-29-18/h3-9,12,14,18,22H,2,10-11,13H2,1H3,(H,24,27)/t18-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256417
PNG
(US9487501, 18)
Show SMILES COc1cccc(n1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C20H21N5O3/c1-27-19-4-2-3-18(24-19)25-13-15(11-22-25)20(26)23-16-7-5-14(6-8-16)17-12-21-9-10-28-17/h2-8,11,13,17,21H,9-10,12H2,1H3,(H,23,26)/t17-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256426
PNG
(US9487501, 27)
Show SMILES FC(F)Oc1ccc(cc1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@@H]1CNCCO1
Show InChI InChI=1S/C21H20F2N4O3/c22-21(23)30-18-7-5-17(6-8-18)27-13-15(11-25-27)20(28)26-16-3-1-14(2-4-16)19-12-24-9-10-29-19/h1-8,11,13,19,21,24H,9-10,12H2,(H,26,28)/t19-/m0/s1
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Hoffmann-La Roche Inc.

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Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256421
PNG
(US9487501, 22)
Show SMILES FC(F)Oc1cccc(c1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C21H20F2N4O3/c22-21(23)30-18-3-1-2-17(10-18)27-13-15(11-25-27)20(28)26-16-6-4-14(5-7-16)19-12-24-8-9-29-19/h1-7,10-11,13,19,21,24H,8-9,12H2,(H,26,28)/t19-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256456
PNG
(US9487501, 57)
Show SMILES FC(F)(F)c1csc(n1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C18H16F3N5O2S/c19-18(20,21)15-10-29-17(25-15)26-9-12(7-23-26)16(27)24-13-3-1-11(2-4-13)14-8-22-5-6-28-14/h1-4,7,9-10,14,22H,5-6,8H2,(H,24,27)/t14-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256411
PNG
(US9487501, 12)
Show SMILES Fc1ccc(cc1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@@H]1CNCCO1
Show InChI InChI=1S/C20H19FN4O2/c21-16-3-7-18(8-4-16)25-13-15(11-23-25)20(26)24-17-5-1-14(2-6-17)19-12-22-9-10-27-19/h1-8,11,13,19,22H,9-10,12H2,(H,24,26)/t19-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256453
PNG
(US9487501, 54)
Show SMILES FC(F)Oc1ccc(cc1)-n1cc(cn1)C(=O)Nc1ccc(cc1)C1CCNC1
Show InChI InChI=1S/C21H20F2N4O2/c22-21(23)29-19-7-5-18(6-8-19)27-13-16(12-25-27)20(28)26-17-3-1-14(2-4-17)15-9-10-24-11-15/h1-8,12-13,15,21,24H,9-11H2,(H,26,28)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256411
PNG
(US9487501, 12)
Show SMILES Fc1ccc(cc1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@@H]1CNCCO1
Show InChI InChI=1S/C20H19FN4O2/c21-16-3-7-18(8-4-16)25-13-15(11-23-25)20(26)24-17-5-1-14(2-6-17)19-12-22-9-10-27-19/h1-8,11,13,19,22H,9-10,12H2,(H,24,26)/t19-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256409
PNG
(US9487501, 10)
Show SMILES Ic1ccc(nc1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C19H18IN5O2/c20-15-3-6-18(22-10-15)25-12-14(9-23-25)19(26)24-16-4-1-13(2-5-16)17-11-21-7-8-27-17/h1-6,9-10,12,17,21H,7-8,11H2,(H,24,26)/t17-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256430
PNG
(US9487501, 31)
Show SMILES Cc1c(cnn1-c1ccc(OC(F)F)cc1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C22H22F2N4O3/c1-14-19(12-26-28(14)17-6-8-18(9-7-17)31-22(23)24)21(29)27-16-4-2-15(3-5-16)20-13-25-10-11-30-20/h2-9,12,20,22,25H,10-11,13H2,1H3,(H,27,29)/t20-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256426
PNG
(US9487501, 27)
Show SMILES FC(F)Oc1ccc(cc1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@@H]1CNCCO1
Show InChI InChI=1S/C21H20F2N4O3/c22-21(23)30-18-7-5-17(6-8-18)27-13-15(11-25-27)20(28)26-16-3-1-14(2-4-16)19-12-24-9-10-29-19/h1-8,11,13,19,21,24H,9-10,12H2,(H,26,28)/t19-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256413
PNG
(US9487501, 14)
Show SMILES FC(F)(F)c1ccnc(c1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C20H18F3N5O2/c21-20(22,23)15-5-6-25-18(9-15)28-12-14(10-26-28)19(29)27-16-3-1-13(2-4-16)17-11-24-7-8-30-17/h1-6,9-10,12,17,24H,7-8,11H2,(H,27,29)/t17-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256421
PNG
(US9487501, 22)
Show SMILES FC(F)Oc1cccc(c1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C21H20F2N4O3/c22-21(23)30-18-3-1-2-17(10-18)27-13-15(11-25-27)20(28)26-16-6-4-14(5-7-16)19-12-24-8-9-29-19/h1-7,10-11,13,19,21,24H,8-9,12H2,(H,26,28)/t19-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256428
PNG
(US9487501, 29)
Show SMILES FC1(F)Oc2ccc(cc2O1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C21H18F2N4O4/c22-21(23)30-17-6-5-16(9-18(17)31-21)27-12-14(10-25-27)20(28)26-15-3-1-13(2-4-15)19-11-24-7-8-29-19/h1-6,9-10,12,19,24H,7-8,11H2,(H,26,28)/t19-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256416
PNG
(US9487501, 17)
Show SMILES Brc1ccc(c(c1)C#N)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C21H18BrN5O2/c22-17-3-6-19(15(9-17)10-23)27-13-16(11-25-27)21(28)26-18-4-1-14(2-5-18)20-12-24-7-8-29-20/h1-6,9,11,13,20,24H,7-8,12H2,(H,26,28)/t20-/m1/s1
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1.5n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256404
PNG
(US9487501, 5)
Show SMILES Fc1cccc(c1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C20H19FN4O2/c21-16-2-1-3-18(10-16)25-13-15(11-23-25)20(26)24-17-6-4-14(5-7-17)19-12-22-8-9-27-19/h1-7,10-11,13,19,22H,8-9,12H2,(H,24,26)/t19-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256414
PNG
(US9487501, 15)
Show SMILES Clc1ccnc(c1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C19H18ClN5O2/c20-15-5-6-22-18(9-15)25-12-14(10-23-25)19(26)24-16-3-1-13(2-4-16)17-11-21-7-8-27-17/h1-6,9-10,12,17,21H,7-8,11H2,(H,24,26)/t17-/m1/s1
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1.60n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256406
PNG
(US9487501, 7)
Show SMILES Clc1ccc(nc1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C19H18ClN5O2/c20-15-3-6-18(22-10-15)25-12-14(9-23-25)19(26)24-16-4-1-13(2-5-16)17-11-21-7-8-27-17/h1-6,9-10,12,17,21H,7-8,11H2,(H,24,26)/t17-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256453
PNG
(US9487501, 54)
Show SMILES FC(F)Oc1ccc(cc1)-n1cc(cn1)C(=O)Nc1ccc(cc1)C1CCNC1
Show InChI InChI=1S/C21H20F2N4O2/c22-21(23)29-19-7-5-18(6-8-19)27-13-16(12-25-27)20(28)26-17-3-1-14(2-4-17)15-9-10-24-11-15/h1-8,12-13,15,21,24H,9-11H2,(H,26,28)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256420
PNG
(US9487501, 21)
Show SMILES FC(F)Oc1ccc(cc1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C21H20F2N4O3/c22-21(23)30-18-7-5-17(6-8-18)27-13-15(11-25-27)20(28)26-16-3-1-14(2-4-16)19-12-24-9-10-29-19/h1-8,11,13,19,21,24H,9-10,12H2,(H,26,28)/t19-/m1/s1
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1.70n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256408
PNG
(US9487501, 9)
Show SMILES Brc1ccc(nc1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C19H18BrN5O2/c20-15-3-6-18(22-10-15)25-12-14(9-23-25)19(26)24-16-4-1-13(2-5-16)17-11-21-7-8-27-17/h1-6,9-10,12,17,21H,7-8,11H2,(H,24,26)/t17-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256456
PNG
(US9487501, 57)
Show SMILES FC(F)(F)c1csc(n1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C18H16F3N5O2S/c19-18(20,21)15-10-29-17(25-15)26-9-12(7-23-26)16(27)24-13-3-1-11(2-4-13)14-8-22-5-6-28-14/h1-4,7,9-10,14,22H,5-6,8H2,(H,24,27)/t14-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256413
PNG
(US9487501, 14)
Show SMILES FC(F)(F)c1ccnc(c1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C20H18F3N5O2/c21-20(22,23)15-5-6-25-18(9-15)28-12-14(10-26-28)19(29)27-16-3-1-13(2-4-16)17-11-24-7-8-30-17/h1-6,9-10,12,17,24H,7-8,11H2,(H,27,29)/t17-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256454
PNG
(US9487501, 55)
Show SMILES FC(F)Oc1ccc(cc1)-n1cc(cn1)C(=O)Nc1ccc(cc1)C1CCCNC1
Show InChI InChI=1S/C22H22F2N4O2/c23-22(24)30-20-9-7-19(8-10-20)28-14-17(13-26-28)21(29)27-18-5-3-15(4-6-18)16-2-1-11-25-12-16/h3-10,13-14,16,22,25H,1-2,11-12H2,(H,27,29)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256416
PNG
(US9487501, 17)
Show SMILES Brc1ccc(c(c1)C#N)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C21H18BrN5O2/c22-17-3-6-19(15(9-17)10-23)27-13-16(11-25-27)21(28)26-18-4-1-14(2-5-18)20-12-24-7-8-29-20/h1-6,9,11,13,20,24H,7-8,12H2,(H,26,28)/t20-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256427
PNG
(US9487501, 28)
Show SMILES CCOc1cccc(n1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C21H23N5O3/c1-2-28-20-5-3-4-19(25-20)26-14-16(12-23-26)21(27)24-17-8-6-15(7-9-17)18-13-22-10-11-29-18/h3-9,12,14,18,22H,2,10-11,13H2,1H3,(H,24,27)/t18-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256412
PNG
(US9487501, 13)
Show SMILES O=C(Nc1ccc(cc1)[C@H]1CNCCO1)c1cnn(c1)-c1cccc(c1)C#N
Show InChI InChI=1S/C21H19N5O2/c22-11-15-2-1-3-19(10-15)26-14-17(12-24-26)21(27)25-18-6-4-16(5-7-18)20-13-23-8-9-28-20/h1-7,10,12,14,20,23H,8-9,13H2,(H,25,27)/t20-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256410
PNG
(US9487501, 11)
Show SMILES FC(F)(F)c1ccc(nc1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C20H18F3N5O2/c21-20(22,23)15-3-6-18(25-10-15)28-12-14(9-26-28)19(29)27-16-4-1-13(2-5-16)17-11-24-7-8-30-17/h1-6,9-10,12,17,24H,7-8,11H2,(H,27,29)/t17-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256410
PNG
(US9487501, 11)
Show SMILES FC(F)(F)c1ccc(nc1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C20H18F3N5O2/c21-20(22,23)15-3-6-18(25-10-15)28-12-14(9-26-28)19(29)27-16-4-1-13(2-5-16)17-11-24-7-8-30-17/h1-6,9-10,12,17,24H,7-8,11H2,(H,27,29)/t17-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256428
PNG
(US9487501, 29)
Show SMILES FC1(F)Oc2ccc(cc2O1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C21H18F2N4O4/c22-21(23)30-17-6-5-16(9-18(17)31-21)27-12-14(10-25-27)20(28)26-15-3-1-13(2-4-15)19-11-24-7-8-29-19/h1-6,9-10,12,19,24H,7-8,11H2,(H,26,28)/t19-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256402
PNG
(US9487501, 3)
Show SMILES COc1ccc(cc1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C21H22N4O3/c1-27-19-8-6-18(7-9-19)25-14-16(12-23-25)21(26)24-17-4-2-15(3-5-17)20-13-22-10-11-28-20/h2-9,12,14,20,22H,10-11,13H2,1H3,(H,24,26)/t20-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256405
PNG
(US9487501, 6)
Show SMILES O=C(Nc1ccc(cc1)[C@H]1CNCCO1)c1cnn(c1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C21H19N5O2/c22-11-15-1-7-19(8-2-15)26-14-17(12-24-26)21(27)25-18-5-3-16(4-6-18)20-13-23-9-10-28-20/h1-8,12,14,20,23H,9-10,13H2,(H,25,27)/t20-/m1/s1
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2.80n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256417
PNG
(US9487501, 18)
Show SMILES COc1cccc(n1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C20H21N5O3/c1-27-19-4-2-3-18(24-19)25-13-15(11-22-25)20(26)23-16-7-5-14(6-8-16)17-12-21-9-10-28-17/h2-8,11,13,17,21H,9-10,12H2,1H3,(H,23,26)/t17-/m1/s1
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2.90n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256415
PNG
(US9487501, 16)
Show SMILES Brc1cc(ccn1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C19H18BrN5O2/c20-18-9-16(5-6-22-18)25-12-14(10-23-25)19(26)24-15-3-1-13(2-4-15)17-11-21-7-8-27-17/h1-6,9-10,12,17,21H,7-8,11H2,(H,24,26)/t17-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256454
PNG
(US9487501, 55)
Show SMILES FC(F)Oc1ccc(cc1)-n1cc(cn1)C(=O)Nc1ccc(cc1)C1CCCNC1
Show InChI InChI=1S/C22H22F2N4O2/c23-22(24)30-20-9-7-19(8-10-20)28-14-17(13-26-28)21(29)27-18-5-3-15(4-6-18)16-2-1-11-25-12-16/h3-10,13-14,16,22,25H,1-2,11-12H2,(H,27,29)
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256445
PNG
(US9487501, 46)
Show SMILES Clc1cnc(cn1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C18H17ClN6O2/c19-16-9-22-17(10-21-16)25-11-13(7-23-25)18(26)24-14-3-1-12(2-4-14)15-8-20-5-6-27-15/h1-4,7,9-11,15,20H,5-6,8H2,(H,24,26)/t15-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256432
PNG
(US9487501, 33)
Show SMILES Clc1cncc(n1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C18H17ClN6O2/c19-16-9-21-10-17(24-16)25-11-13(7-22-25)18(26)23-14-3-1-12(2-4-14)15-8-20-5-6-27-15/h1-4,7,9-11,15,20H,5-6,8H2,(H,23,26)/t15-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256403
PNG
(US9487501, 4)
Show SMILES Fc1ccc(cc1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C20H19FN4O2/c21-16-3-7-18(8-4-16)25-13-15(11-23-25)20(26)24-17-5-1-14(2-6-17)19-12-22-9-10-27-19/h1-8,11,13,19,22H,9-10,12H2,(H,24,26)/t19-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256448
PNG
(US9487501, 49)
Show SMILES Fc1cc(ccc1-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@@H]1CNCCO1)C#N
Show InChI InChI=1S/C21H18FN5O2/c22-18-9-14(10-23)1-6-19(18)27-13-16(11-25-27)21(28)26-17-4-2-15(3-5-17)20-12-24-7-8-29-20/h1-6,9,11,13,20,24H,7-8,12H2,(H,26,28)/t20-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256415
PNG
(US9487501, 16)
Show SMILES Brc1cc(ccn1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C19H18BrN5O2/c20-18-9-16(5-6-22-18)25-12-14(10-23-25)19(26)24-15-3-1-13(2-4-15)17-11-21-7-8-27-17/h1-6,9-10,12,17,21H,7-8,11H2,(H,24,26)/t17-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256433
PNG
(US9487501, 34)
Show SMILES FC(F)(F)c1nccc(n1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C19H17F3N6O2/c20-19(21,22)18-24-6-5-16(27-18)28-11-13(9-25-28)17(29)26-14-3-1-12(2-4-14)15-10-23-7-8-30-15/h1-6,9,11,15,23H,7-8,10H2,(H,26,29)/t15-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256414
PNG
(US9487501, 15)
Show SMILES Clc1ccnc(c1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C19H18ClN5O2/c20-15-5-6-22-18(9-15)25-12-14(10-23-25)19(26)24-16-3-1-13(2-4-16)17-11-21-7-8-27-17/h1-6,9-10,12,17,21H,7-8,11H2,(H,24,26)/t17-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256449
PNG
(US9487501, 50)
Show SMILES FC(F)(F)c1cc(ccn1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C20H18F3N5O2/c21-20(22,23)18-9-16(5-6-25-18)28-12-14(10-26-28)19(29)27-15-3-1-13(2-4-15)17-11-24-7-8-30-17/h1-6,9-10,12,17,24H,7-8,11H2,(H,27,29)/t17-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256452
PNG
(US9487501, 53)
Show SMILES FC(F)(F)c1cnc(cn1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C19H17F3N6O2/c20-19(21,22)16-9-25-17(10-24-16)28-11-13(7-26-28)18(29)27-14-3-1-12(2-4-14)15-8-23-5-6-30-15/h1-4,7,9-11,15,23H,5-6,8H2,(H,27,29)/t15-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256404
PNG
(US9487501, 5)
Show SMILES Fc1cccc(c1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C20H19FN4O2/c21-16-2-1-3-18(10-16)25-13-15(11-23-25)20(26)24-17-6-4-14(5-7-17)19-12-22-8-9-27-19/h1-7,10-11,13,19,22H,8-9,12H2,(H,24,26)/t19-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256420
PNG
(US9487501, 21)
Show SMILES FC(F)Oc1ccc(cc1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C21H20F2N4O3/c22-21(23)30-18-7-5-17(6-8-18)27-13-15(11-25-27)20(28)26-16-3-1-14(2-4-16)19-12-24-9-10-29-19/h1-8,11,13,19,21,24H,9-10,12H2,(H,26,28)/t19-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256419
PNG
(US9487501, 20)
Show SMILES Clc1cc(ccn1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C19H18ClN5O2/c20-18-9-16(5-6-22-18)25-12-14(10-23-25)19(26)24-15-3-1-13(2-4-15)17-11-21-7-8-27-17/h1-6,9-10,12,17,21H,7-8,11H2,(H,24,26)/t17-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256443
PNG
(US9487501, 44)
Show SMILES FC(F)(F)c1cc(ncn1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C19H17F3N6O2/c20-19(21,22)16-7-17(25-11-24-16)28-10-13(8-26-28)18(29)27-14-3-1-12(2-4-14)15-9-23-5-6-30-15/h1-4,7-8,10-11,15,23H,5-6,9H2,(H,27,29)/t15-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256422
PNG
(US9487501, 23)
Show SMILES Fc1cc(ccc1-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1)C#N
Show InChI InChI=1S/C21H18FN5O2/c22-18-9-14(10-23)1-6-19(18)27-13-16(11-25-27)21(28)26-17-4-2-15(3-5-17)20-12-24-7-8-29-20/h1-6,9,11,13,20,24H,7-8,12H2,(H,26,28)/t20-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256409
PNG
(US9487501, 10)
Show SMILES Ic1ccc(nc1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C19H18IN5O2/c20-15-3-6-18(22-10-15)25-12-14(9-23-25)19(26)24-16-4-1-13(2-5-16)17-11-21-7-8-27-17/h1-6,9-10,12,17,21H,7-8,11H2,(H,24,26)/t17-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256408
PNG
(US9487501, 9)
Show SMILES Brc1ccc(nc1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C19H18BrN5O2/c20-15-3-6-18(22-10-15)25-12-14(9-23-25)19(26)24-16-4-1-13(2-5-16)17-11-21-7-8-27-17/h1-6,9-10,12,17,21H,7-8,11H2,(H,24,26)/t17-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256406
PNG
(US9487501, 7)
Show SMILES Clc1ccc(nc1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C19H18ClN5O2/c20-15-3-6-18(22-10-15)25-12-14(9-23-25)19(26)24-16-4-1-13(2-5-16)17-11-21-7-8-27-17/h1-6,9-10,12,17,21H,7-8,11H2,(H,24,26)/t17-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256450
PNG
(US9487501, 51)
Show SMILES FC(F)(F)c1ccc(cn1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C20H18F3N5O2/c21-20(22,23)18-6-5-16(10-25-18)28-12-14(9-26-28)19(29)27-15-3-1-13(2-4-15)17-11-24-7-8-30-17/h1-6,9-10,12,17,24H,7-8,11H2,(H,27,29)/t17-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256448
PNG
(US9487501, 49)
Show SMILES Fc1cc(ccc1-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@@H]1CNCCO1)C#N
Show InChI InChI=1S/C21H18FN5O2/c22-18-9-14(10-23)1-6-19(18)27-13-16(11-25-27)21(28)26-17-4-2-15(3-5-17)20-12-24-7-8-29-20/h1-6,9,11,13,20,24H,7-8,12H2,(H,26,28)/t20-/m0/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256455
PNG
(US9487501, 56)
Show SMILES O=C(Nc1ccc(cc1)[C@H]1CNCCO1)c1cnn(c1)-c1cc(ncn1)C1CC1
Show InChI InChI=1S/C21H22N6O2/c28-21(26-17-5-3-15(4-6-17)19-11-22-7-8-29-19)16-10-25-27(12-16)20-9-18(14-1-2-14)23-13-24-20/h3-6,9-10,12-14,19,22H,1-2,7-8,11H2,(H,26,28)/t19-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256455
PNG
(US9487501, 56)
Show SMILES O=C(Nc1ccc(cc1)[C@H]1CNCCO1)c1cnn(c1)-c1cc(ncn1)C1CC1
Show InChI InChI=1S/C21H22N6O2/c28-21(26-17-5-3-15(4-6-17)19-11-22-7-8-29-19)16-10-25-27(12-16)20-9-18(14-1-2-14)23-13-24-20/h3-6,9-10,12-14,19,22H,1-2,7-8,11H2,(H,26,28)/t19-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256435
PNG
(US9487501, 36)
Show SMILES Clc1nccc(n1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C18H17ClN6O2/c19-18-21-6-5-16(24-18)25-11-13(9-22-25)17(26)23-14-3-1-12(2-4-14)15-10-20-7-8-27-15/h1-6,9,11,15,20H,7-8,10H2,(H,23,26)/t15-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256433
PNG
(US9487501, 34)
Show SMILES FC(F)(F)c1nccc(n1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C19H17F3N6O2/c20-19(21,22)18-24-6-5-16(27-18)28-11-13(9-25-28)17(29)26-14-3-1-12(2-4-14)15-10-23-7-8-30-15/h1-6,9,11,15,23H,7-8,10H2,(H,26,29)/t15-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256445
PNG
(US9487501, 46)
Show SMILES Clc1cnc(cn1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C18H17ClN6O2/c19-16-9-22-17(10-21-16)25-11-13(7-23-25)18(26)24-14-3-1-12(2-4-14)15-8-20-5-6-27-15/h1-4,7,9-11,15,20H,5-6,8H2,(H,24,26)/t15-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256444
PNG
(US9487501, 45)
Show SMILES FC(F)(F)c1ncc(cn1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C19H17F3N6O2/c20-19(21,22)18-24-8-15(9-25-18)28-11-13(7-26-28)17(29)27-14-3-1-12(2-4-14)16-10-23-5-6-30-16/h1-4,7-9,11,16,23H,5-6,10H2,(H,27,29)/t16-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


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More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256419
PNG
(US9487501, 20)
Show SMILES Clc1cc(ccn1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C19H18ClN5O2/c20-18-9-16(5-6-22-18)25-12-14(10-23-25)19(26)24-15-3-1-13(2-4-15)17-11-21-7-8-27-17/h1-6,9-10,12,17,21H,7-8,11H2,(H,24,26)/t17-/m1/s1
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5.90n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256437
PNG
(US9487501, 38)
Show SMILES FC(F)(F)c1cncc(n1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C19H17F3N6O2/c20-19(21,22)16-9-24-10-17(27-16)28-11-13(7-25-28)18(29)26-14-3-1-12(2-4-14)15-8-23-5-6-30-15/h1-4,7,9-11,15,23H,5-6,8H2,(H,26,29)/t15-/m1/s1
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5.90n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256450
PNG
(US9487501, 51)
Show SMILES FC(F)(F)c1ccc(cn1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C20H18F3N5O2/c21-20(22,23)18-6-5-16(10-25-18)28-12-14(9-26-28)19(29)27-15-3-1-13(2-4-15)17-11-24-7-8-30-17/h1-6,9-10,12,17,24H,7-8,11H2,(H,27,29)/t17-/m1/s1
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6.40n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256432
PNG
(US9487501, 33)
Show SMILES Clc1cncc(n1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C18H17ClN6O2/c19-16-9-21-10-17(24-16)25-11-13(7-22-25)18(26)23-14-3-1-12(2-4-14)15-8-20-5-6-27-15/h1-4,7,9-11,15,20H,5-6,8H2,(H,23,26)/t15-/m1/s1
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6.80n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256405
PNG
(US9487501, 6)
Show SMILES O=C(Nc1ccc(cc1)[C@H]1CNCCO1)c1cnn(c1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C21H19N5O2/c22-11-15-1-7-19(8-2-15)26-14-17(12-24-26)21(27)25-18-5-3-16(4-6-18)20-13-23-9-10-28-20/h1-8,12,14,20,23H,9-10,13H2,(H,25,27)/t20-/m1/s1
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7n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256422
PNG
(US9487501, 23)
Show SMILES Fc1cc(ccc1-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1)C#N
Show InChI InChI=1S/C21H18FN5O2/c22-18-9-14(10-23)1-6-19(18)27-13-16(11-25-27)21(28)26-17-4-2-15(3-5-17)20-12-24-7-8-29-20/h1-6,9,11,13,20,24H,7-8,12H2,(H,26,28)/t20-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256412
PNG
(US9487501, 13)
Show SMILES O=C(Nc1ccc(cc1)[C@H]1CNCCO1)c1cnn(c1)-c1cccc(c1)C#N
Show InChI InChI=1S/C21H19N5O2/c22-11-15-2-1-3-19(10-15)26-14-17(12-24-26)21(27)25-18-6-4-16(5-7-18)20-13-23-8-9-28-20/h1-7,10,12,14,20,23H,8-9,13H2,(H,25,27)/t20-/m1/s1
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7.20n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256437
PNG
(US9487501, 38)
Show SMILES FC(F)(F)c1cncc(n1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C19H17F3N6O2/c20-19(21,22)16-9-24-10-17(27-16)28-11-13(7-25-28)18(29)26-14-3-1-12(2-4-14)15-8-23-5-6-30-15/h1-4,7,9-11,15,23H,5-6,8H2,(H,26,29)/t15-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256449
PNG
(US9487501, 50)
Show SMILES FC(F)(F)c1cc(ccn1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C20H18F3N5O2/c21-20(22,23)18-9-16(5-6-25-18)28-12-14(10-26-28)19(29)27-15-3-1-13(2-4-15)17-11-24-7-8-30-17/h1-6,9-10,12,17,24H,7-8,11H2,(H,27,29)/t17-/m1/s1
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7.70n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256424
PNG
(US9487501, 25)
Show SMILES Fc1ccc(c(c1)C#N)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C21H18FN5O2/c22-17-3-6-19(15(9-17)10-23)27-13-16(11-25-27)21(28)26-18-4-1-14(2-5-18)20-12-24-7-8-29-20/h1-6,9,11,13,20,24H,7-8,12H2,(H,26,28)/t20-/m1/s1
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7.80n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256424
PNG
(US9487501, 25)
Show SMILES Fc1ccc(c(c1)C#N)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C21H18FN5O2/c22-17-3-6-19(15(9-17)10-23)27-13-16(11-25-27)21(28)26-18-4-1-14(2-5-18)20-12-24-7-8-29-20/h1-6,9,11,13,20,24H,7-8,12H2,(H,26,28)/t20-/m1/s1
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8.20n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256452
PNG
(US9487501, 53)
Show SMILES FC(F)(F)c1cnc(cn1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C19H17F3N6O2/c20-19(21,22)16-9-25-17(10-24-16)28-11-13(7-26-28)18(29)27-14-3-1-12(2-4-14)15-8-23-5-6-30-15/h1-4,7,9-11,15,23H,5-6,8H2,(H,27,29)/t15-/m1/s1
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Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256435
PNG
(US9487501, 36)
Show SMILES Clc1nccc(n1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C18H17ClN6O2/c19-18-21-6-5-16(24-18)25-11-13(9-22-25)17(26)23-14-3-1-12(2-4-14)15-10-20-7-8-27-15/h1-6,9,11,15,20H,7-8,10H2,(H,23,26)/t15-/m1/s1
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8.60n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256400
PNG
(US9487501, 1)
Show SMILES Cc1c(cnn1-c1ccccc1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C21H22N4O2/c1-15-19(13-23-25(15)18-5-3-2-4-6-18)21(26)24-17-9-7-16(8-10-17)20-14-22-11-12-27-20/h2-10,13,20,22H,11-12,14H2,1H3,(H,24,26)/t20-/m1/s1
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8.60n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256438
PNG
(US9487501, 39)
Show SMILES Cc1cncc(n1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C19H20N6O2/c1-13-8-21-11-18(23-13)25-12-15(9-22-25)19(26)24-16-4-2-14(3-5-16)17-10-20-6-7-27-17/h2-5,8-9,11-12,17,20H,6-7,10H2,1H3,(H,24,26)/t17-/m1/s1
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8.80n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256407
PNG
(US9487501, 8)
Show SMILES O=C(Nc1ccc(cc1)[C@H]1CNCCO1)c1cnn(c1)-c1ccc(cn1)C#N
Show InChI InChI=1S/C20H18N6O2/c21-9-14-1-6-19(23-10-14)26-13-16(11-24-26)20(27)25-17-4-2-15(3-5-17)18-12-22-7-8-28-18/h1-6,10-11,13,18,22H,7-8,12H2,(H,25,27)/t18-/m1/s1
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8.90n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256443
PNG
(US9487501, 44)
Show SMILES FC(F)(F)c1cc(ncn1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C19H17F3N6O2/c20-19(21,22)16-7-17(25-11-24-16)28-10-13(8-26-28)18(29)27-14-3-1-12(2-4-14)15-9-23-5-6-30-15/h1-4,7-8,10-11,15,23H,5-6,9H2,(H,27,29)/t15-/m1/s1
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9.90n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256439
PNG
(US9487501, 40)
Show SMILES Cc1cnc(cn1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C19H20N6O2/c1-13-8-22-18(11-21-13)25-12-15(9-23-25)19(26)24-16-4-2-14(3-5-16)17-10-20-6-7-27-17/h2-5,8-9,11-12,17,20H,6-7,10H2,1H3,(H,24,26)/t17-/m1/s1
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11.9n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256418
PNG
(US9487501, 19)
Show SMILES Fc1cc(cnc1-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1)C(F)(F)F
Show InChI InChI=1S/C20H17F4N5O2/c21-16-7-14(20(22,23)24)9-26-18(16)29-11-13(8-27-29)19(30)28-15-3-1-12(2-4-15)17-10-25-5-6-31-17/h1-4,7-9,11,17,25H,5-6,10H2,(H,28,30)/t17-/m1/s1
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13.5n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256401
PNG
(US9487501, 2)
Show SMILES Nc1c(cnn1-c1ccc(F)cc1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C20H20FN5O2/c21-14-3-7-16(8-4-14)26-19(22)17(11-24-26)20(27)25-15-5-1-13(2-6-15)18-12-23-9-10-28-18/h1-8,11,18,23H,9-10,12,22H2,(H,25,27)/t18-/m1/s1
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14.4n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256407
PNG
(US9487501, 8)
Show SMILES O=C(Nc1ccc(cc1)[C@H]1CNCCO1)c1cnn(c1)-c1ccc(cn1)C#N
Show InChI InChI=1S/C20H18N6O2/c21-9-14-1-6-19(23-10-14)26-13-16(11-24-26)20(27)25-17-4-2-15(3-5-17)18-12-22-7-8-28-18/h1-6,10-11,13,18,22H,7-8,12H2,(H,25,27)/t18-/m1/s1
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14.7n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256423
PNG
(US9487501, 24)
Show SMILES Fc1cc(ccc1C#N)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C21H18FN5O2/c22-19-9-18(6-3-15(19)10-23)27-13-16(11-25-27)21(28)26-17-4-1-14(2-5-17)20-12-24-7-8-29-20/h1-6,9,11,13,20,24H,7-8,12H2,(H,26,28)/t20-/m1/s1
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15.4n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256418
PNG
(US9487501, 19)
Show SMILES Fc1cc(cnc1-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1)C(F)(F)F
Show InChI InChI=1S/C20H17F4N5O2/c21-16-7-14(20(22,23)24)9-26-18(16)29-11-13(8-27-29)19(30)28-15-3-1-12(2-4-15)17-10-25-5-6-31-17/h1-4,7-9,11,17,25H,5-6,10H2,(H,28,30)/t17-/m1/s1
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16n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256402
PNG
(US9487501, 3)
Show SMILES COc1ccc(cc1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C21H22N4O3/c1-27-19-8-6-18(7-9-19)25-14-16(12-23-25)21(26)24-17-4-2-15(3-5-17)20-13-22-10-11-28-20/h2-9,12,14,20,22H,10-11,13H2,1H3,(H,24,26)/t20-/m1/s1
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16.5n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256429
PNG
(US9487501, 30)
Show SMILES Clc1cnc(nc1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C18H17ClN6O2/c19-14-8-21-18(22-9-14)25-11-13(7-23-25)17(26)24-15-3-1-12(2-4-15)16-10-20-5-6-27-16/h1-4,7-9,11,16,20H,5-6,10H2,(H,24,26)/t16-/m1/s1
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16.6n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256423
PNG
(US9487501, 24)
Show SMILES Fc1cc(ccc1C#N)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C21H18FN5O2/c22-19-9-18(6-3-15(19)10-23)27-13-16(11-25-27)21(28)26-17-4-1-14(2-5-17)20-12-24-7-8-29-20/h1-6,9,11,13,20,24H,7-8,12H2,(H,26,28)/t20-/m1/s1
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17.5n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256451
PNG
(US9487501, 52)
Show SMILES O=C(Nc1ccc(cc1)[C@H]1CNCCO1)c1cnn(c1)-c1nccnc1C#N
Show InChI InChI=1S/C19H17N7O2/c20-9-16-18(23-6-5-22-16)26-12-14(10-24-26)19(27)25-15-3-1-13(2-4-15)17-11-21-7-8-28-17/h1-6,10,12,17,21H,7-8,11H2,(H,25,27)/t17-/m1/s1
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17.9n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256446
PNG
(US9487501, 47)
Show SMILES O=C(Nc1ccc(cc1)[C@H]1CNCCO1)c1cnn(c1)-c1cncc(n1)C#N
Show InChI InChI=1S/C19H17N7O2/c20-7-16-9-22-11-18(24-16)26-12-14(8-23-26)19(27)25-15-3-1-13(2-4-15)17-10-21-5-6-28-17/h1-4,8-9,11-12,17,21H,5-6,10H2,(H,25,27)/t17-/m1/s1
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19.5n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256441
PNG
(US9487501, 42)
Show SMILES O=C(Nc1ccc(cc1)[C@H]1CNCCO1)c1cnn(c1)-c1cnc(cn1)C#N
Show InChI InChI=1S/C19H17N7O2/c20-7-16-9-23-18(11-22-16)26-12-14(8-24-26)19(27)25-15-3-1-13(2-4-15)17-10-21-5-6-28-17/h1-4,8-9,11-12,17,21H,5-6,10H2,(H,25,27)/t17-/m1/s1
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19.9n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256444
PNG
(US9487501, 45)
Show SMILES FC(F)(F)c1ncc(cn1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C19H17F3N6O2/c20-19(21,22)18-24-8-15(9-25-18)28-11-13(7-26-28)17(29)27-14-3-1-12(2-4-14)16-10-23-5-6-30-16/h1-4,7-9,11,16,23H,5-6,10H2,(H,27,29)/t16-/m1/s1
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21.4n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256440
PNG
(US9487501, 41)
Show SMILES Clc1nccnc1-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C18H17ClN6O2/c19-16-17(22-6-5-21-16)25-11-13(9-23-25)18(26)24-14-3-1-12(2-4-14)15-10-20-7-8-27-15/h1-6,9,11,15,20H,7-8,10H2,(H,24,26)/t15-/m1/s1
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27.5n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256441
PNG
(US9487501, 42)
Show SMILES O=C(Nc1ccc(cc1)[C@H]1CNCCO1)c1cnn(c1)-c1cnc(cn1)C#N
Show InChI InChI=1S/C19H17N7O2/c20-7-16-9-23-18(11-22-16)26-12-14(8-24-26)19(27)25-15-3-1-13(2-4-15)17-10-21-5-6-28-17/h1-4,8-9,11-12,17,21H,5-6,10H2,(H,25,27)/t17-/m1/s1
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32.6n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256446
PNG
(US9487501, 47)
Show SMILES O=C(Nc1ccc(cc1)[C@H]1CNCCO1)c1cnn(c1)-c1cncc(n1)C#N
Show InChI InChI=1S/C19H17N7O2/c20-7-16-9-22-11-18(24-16)26-12-14(8-23-26)19(27)25-15-3-1-13(2-4-15)17-10-21-5-6-28-17/h1-4,8-9,11-12,17,21H,5-6,10H2,(H,25,27)/t17-/m1/s1
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34.5n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256438
PNG
(US9487501, 39)
Show SMILES Cc1cncc(n1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C19H20N6O2/c1-13-8-21-11-18(23-13)25-12-15(9-22-25)19(26)24-16-4-2-14(3-5-16)17-10-20-6-7-27-17/h2-5,8-9,11-12,17,20H,6-7,10H2,1H3,(H,24,26)/t17-/m1/s1
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43.5n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256430
PNG
(US9487501, 31)
Show SMILES Cc1c(cnn1-c1ccc(OC(F)F)cc1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C22H22F2N4O3/c1-14-19(12-26-28(14)17-6-8-18(9-7-17)31-22(23)24)21(29)27-16-4-2-15(3-5-16)20-13-25-10-11-30-20/h2-9,12,20,22,25H,10-11,13H2,1H3,(H,27,29)/t20-/m1/s1
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45n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256451
PNG
(US9487501, 52)
Show SMILES O=C(Nc1ccc(cc1)[C@H]1CNCCO1)c1cnn(c1)-c1nccnc1C#N
Show InChI InChI=1S/C19H17N7O2/c20-9-16-18(23-6-5-22-16)26-12-14(10-24-26)19(27)25-15-3-1-13(2-4-15)17-11-21-7-8-28-17/h1-6,10,12,17,21H,7-8,11H2,(H,25,27)/t17-/m1/s1
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45.1n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256447
PNG
(US9487501, 48)
Show SMILES FC(F)(F)c1ccnc(n1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C19H17F3N6O2/c20-19(21,22)16-5-6-24-18(27-16)28-11-13(9-25-28)17(29)26-14-3-1-12(2-4-14)15-10-23-7-8-30-15/h1-6,9,11,15,23H,7-8,10H2,(H,26,29)/t15-/m1/s1
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53.1n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256442
PNG
(US9487501, 43)
Show SMILES Cc1ccnc(n1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C19H20N6O2/c1-13-6-7-21-19(23-13)25-12-15(10-22-25)18(26)24-16-4-2-14(3-5-16)17-11-20-8-9-27-17/h2-7,10,12,17,20H,8-9,11H2,1H3,(H,24,26)/t17-/m1/s1
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55.4n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256434
PNG
(US9487501, 35)
Show SMILES Cc1c(cnn1-c1ccc(cc1)C#N)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C22H21N5O2/c1-15-20(13-25-27(15)19-8-2-16(12-23)3-9-19)22(28)26-18-6-4-17(5-7-18)21-14-24-10-11-29-21/h2-9,13,21,24H,10-11,14H2,1H3,(H,26,28)/t21-/m1/s1
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60.1n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM256436
PNG
(US9487501, 37)
Show SMILES FC(F)(F)c1cnc(nc1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C19H17F3N6O2/c20-19(21,22)14-8-24-18(25-9-14)28-11-13(7-26-28)17(29)27-15-3-1-12(2-4-15)16-10-23-5-6-30-16/h1-4,7-9,11,16,23H,5-6,10H2,(H,27,29)/t16-/m1/s1
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61.5n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256440
PNG
(US9487501, 41)
Show SMILES Clc1nccnc1-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C18H17ClN6O2/c19-16-17(22-6-5-21-16)25-11-13(9-23-25)18(26)24-14-3-1-12(2-4-14)15-10-20-7-8-27-15/h1-6,9,11,15,20H,7-8,10H2,(H,24,26)/t15-/m1/s1
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81.4n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256436
PNG
(US9487501, 37)
Show SMILES FC(F)(F)c1cnc(nc1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C19H17F3N6O2/c20-19(21,22)14-8-24-18(25-9-14)28-11-13(7-26-28)17(29)27-15-3-1-12(2-4-15)16-10-23-5-6-30-16/h1-4,7-9,11,16,23H,5-6,10H2,(H,27,29)/t16-/m1/s1
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93.1n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256439
PNG
(US9487501, 40)
Show SMILES Cc1cnc(cn1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C19H20N6O2/c1-13-8-22-18(11-21-13)25-12-15(9-23-25)19(26)24-16-4-2-14(3-5-16)17-10-20-6-7-27-17/h2-5,8-9,11-12,17,20H,6-7,10H2,1H3,(H,24,26)/t17-/m1/s1
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126n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256429
PNG
(US9487501, 30)
Show SMILES Clc1cnc(nc1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C18H17ClN6O2/c19-14-8-21-18(22-9-14)25-11-13(7-23-25)17(26)24-15-3-1-12(2-4-15)16-10-20-5-6-27-16/h1-4,7-9,11,16,20H,5-6,10H2,(H,24,26)/t16-/m1/s1
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135n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


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More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256447
PNG
(US9487501, 48)
Show SMILES FC(F)(F)c1ccnc(n1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C19H17F3N6O2/c20-19(21,22)16-5-6-24-18(27-16)28-11-13(9-25-28)17(29)26-14-3-1-12(2-4-14)15-10-23-7-8-30-15/h1-6,9,11,15,23H,7-8,10H2,(H,26,29)/t15-/m1/s1
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US Patent
149n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256434
PNG
(US9487501, 35)
Show SMILES Cc1c(cnn1-c1ccc(cc1)C#N)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C22H21N5O2/c1-15-20(13-25-27(15)19-8-2-16(12-23)3-9-19)22(28)26-18-6-4-17(5-7-18)21-14-24-10-11-29-21/h2-9,13,21,24H,10-11,14H2,1H3,(H,26,28)/t21-/m1/s1
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167n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256400
PNG
(US9487501, 1)
Show SMILES Cc1c(cnn1-c1ccccc1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C21H22N4O2/c1-15-19(13-23-25(15)18-5-3-2-4-6-18)21(26)24-17-9-7-16(8-10-17)20-14-22-11-12-27-20/h2-10,13,20,22H,11-12,14H2,1H3,(H,24,26)/t20-/m1/s1
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229n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256442
PNG
(US9487501, 43)
Show SMILES Cc1ccnc(n1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C19H20N6O2/c1-13-6-7-21-19(23-13)25-12-15(10-22-25)18(26)24-16-4-2-14(3-5-16)17-11-20-8-9-27-17/h2-7,10,12,17,20H,8-9,11H2,1H3,(H,24,26)/t17-/m1/s1
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315n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Rattus norvegicus (Rat))
BDBM256401
PNG
(US9487501, 2)
Show SMILES Nc1c(cnn1-c1ccc(F)cc1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1
Show InChI InChI=1S/C20H20FN5O2/c21-14-3-7-16(8-4-14)26-19(22)17(11-24-26)20(27)25-15-5-1-13(2-6-15)18-12-23-9-10-28-18/h1-8,11,18,23H,9-10,12,22H2,(H,25,27)/t18-/m1/s1
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401n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%