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Patent code US9493412

Compile Data Set for Download or QSAR
Found 34 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM254848
PNG
(US9493412, 21)
Show SMILES CC(C)CN1CC(C(=O)NCCCCc2nc(no2)-c2ccc(Cl)c(Cl)c2)=C(O)C1=O
Show InChI InChI=1S/C21H24Cl2N4O4/c1-12(2)10-27-11-14(18(28)21(27)30)20(29)24-8-4-3-5-17-25-19(26-31-17)13-6-7-15(22)16(23)9-13/h6-7,9,12,28H,3-5,8,10-11H2,1-2H3,(H,24,29)
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n/an/a 15.4n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...


Citation and Details
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM254851
PNG
(US9493412, 29)
Show SMILES CN1CC(C(=O)NCCCOc2cccc(Oc3ccccc3)c2)=C(O)C1=O
Show InChI InChI=1S/C21H22N2O5/c1-23-14-18(19(24)21(23)26)20(25)22-11-6-12-27-16-9-5-10-17(13-16)28-15-7-3-2-4-8-15/h2-5,7-10,13,24H,6,11-12,14H2,1H3,(H,22,25)
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n/an/a 22.1n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...


Citation and Details
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM254847
PNG
(US9493412, 18)
Show SMILES CN1CC(C(=O)NCc2ccccc2-c2ccccc2)=C(O)C1=O
Show InChI InChI=1S/C19H18N2O3/c1-21-12-16(17(22)19(21)24)18(23)20-11-14-9-5-6-10-15(14)13-7-3-2-4-8-13/h2-10,22H,11-12H2,1H3,(H,20,23)
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Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...


Citation and Details
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM254846
PNG
(US9493412, 9)
Show SMILES CN1CC(C(=O)NCc2ccc(Oc3ccc(Cl)c(Cl)c3)cc2)=C(O)C1=O
Show InChI InChI=1S/C19H16Cl2N2O4/c1-23-10-14(17(24)19(23)26)18(25)22-9-11-2-4-12(5-3-11)27-13-6-7-15(20)16(21)8-13/h2-8,24H,9-10H2,1H3,(H,22,25)
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n/an/a 27.1n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...


Citation and Details
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM254875
PNG
(US9493412, 48)
Show SMILES C[C@@H](NC(=O)C1=C(O)C(=O)N(C1)c1ccc(F)cc1F)c1cccc(c1)-c1ccc(NC(C)=O)cc1
Show InChI InChI=1S/C27H23F2N3O4/c1-15(18-4-3-5-19(12-18)17-6-9-21(10-7-17)31-16(2)33)30-26(35)22-14-32(27(36)25(22)34)24-11-8-20(28)13-23(24)29/h3-13,15,34H,14H2,1-2H3,(H,30,35)(H,31,33)/t15-/m1/s1
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n/an/a 27.1n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...


Citation and Details
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM254852
PNG
(US9493412, 34)
Show SMILES CN1CC(C(=O)NCc2ccc(Oc3ccc(C)cc3C)cc2)=C(O)C1=O
Show InChI InChI=1S/C21H22N2O4/c1-13-4-9-18(14(2)10-13)27-16-7-5-15(6-8-16)11-22-20(25)17-12-23(3)21(26)19(17)24/h4-10,24H,11-12H2,1-3H3,(H,22,25)
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n/an/a 32.1n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...


Citation and Details
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM254844
PNG
(US9493412, 2)
Show SMILES CN1CC(C(=O)NCc2ccc(Oc3ccccc3)cc2)=C(O)C1=O
Show InChI InChI=1S/C19H18N2O4/c1-21-12-16(17(22)19(21)24)18(23)20-11-13-7-9-15(10-8-13)25-14-5-3-2-4-6-14/h2-10,22H,11-12H2,1H3,(H,20,23)
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Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...


Citation and Details
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM254874
PNG
(US9493412, 218)
Show SMILES CCN1CC(C(=O)N[C@@H]2CCc3cc(ccc23)-c2ccccc2)=C(O)C1=O
Show InChI InChI=1S/C22H22N2O3/c1-2-24-13-18(20(25)22(24)27)21(26)23-19-11-9-16-12-15(8-10-17(16)19)14-6-4-3-5-7-14/h3-8,10,12,19,25H,2,9,11,13H2,1H3,(H,23,26)/t19-/m1/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...


Citation and Details
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM254845
PNG
(US9493412, 8)
Show SMILES CN1CC(C(=O)NCc2ccc(Oc3ccc(F)cc3)cc2)=C(O)C1=O
Show InChI InChI=1S/C19H17FN2O4/c1-22-11-16(17(23)19(22)25)18(24)21-10-12-2-6-14(7-3-12)26-15-8-4-13(20)5-9-15/h2-9,23H,10-11H2,1H3,(H,21,24)
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Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...


Citation and Details
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM254861
PNG
(US9493412, 103)
Show SMILES C[C@@H](NC(=O)C1=C(O)C(=O)N(C)C1)c1cccc(c1)-c1cccc(c1)C(N)=O
Show InChI InChI=1S/C21H21N3O4/c1-12(23-20(27)17-11-24(2)21(28)18(17)25)13-5-3-6-14(9-13)15-7-4-8-16(10-15)19(22)26/h3-10,12,25H,11H2,1-2H3,(H2,22,26)(H,23,27)/t12-/m1/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...


Citation and Details
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM254863
PNG
(US9493412, 146)
Show SMILES CCN1CC(C(=O)N[C@@H]2CCC(c3ccccc3)c3ccccc23)=C(O)C1=O
Show InChI InChI=1S/C23H24N2O3/c1-2-25-14-19(21(26)23(25)28)22(27)24-20-13-12-16(15-8-4-3-5-9-15)17-10-6-7-11-18(17)20/h3-11,16,20,26H,2,12-14H2,1H3,(H,24,27)/t16?,20-/m1/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...


Citation and Details
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM254857
PNG
(US9493412, 85)
Show SMILES CN1CC(C(=O)NCc2cccc(c2)-c2ccc(CNC(C)=O)cc2)=C(O)C1=O
Show InChI InChI=1S/C22H23N3O4/c1-14(26)23-11-15-6-8-17(9-7-15)18-5-3-4-16(10-18)12-24-21(28)19-13-25(2)22(29)20(19)27/h3-10,27H,11-13H2,1-2H3,(H,23,26)(H,24,28)
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Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...


Citation and Details
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM254859
PNG
(US9493412, 92)
Show SMILES C[C@@H](NC(=O)C1=C(O)C(=O)N(C)C1)c1cccc(c1)-c1cccc(F)c1
Show InChI InChI=1S/C20H19FN2O3/c1-12(22-19(25)17-11-23(2)20(26)18(17)24)13-5-3-6-14(9-13)15-7-4-8-16(21)10-15/h3-10,12,24H,11H2,1-2H3,(H,22,25)/t12-/m1/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...


Citation and Details
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM254853
PNG
(US9493412, 62)
Show SMILES CN1CC(C(=O)NCc2cccc(c2)-c2ccccc2Cl)=C(O)C1=O
Show InChI InChI=1S/C19H17ClN2O3/c1-22-11-15(17(23)19(22)25)18(24)21-10-12-5-4-6-13(9-12)14-7-2-3-8-16(14)20/h2-9,23H,10-11H2,1H3,(H,21,24)
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Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...


Citation and Details
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM254854
PNG
(US9493412, 63)
Show SMILES CN1CC(C(=O)NCc2cccc(c2)-c2ccccc2F)=C(O)C1=O
Show InChI InChI=1S/C19H17FN2O3/c1-22-11-15(17(23)19(22)25)18(24)21-10-12-5-4-6-13(9-12)14-7-2-3-8-16(14)20/h2-9,23H,10-11H2,1H3,(H,21,24)
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Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...


Citation and Details
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM254865
PNG
(US9493412, 168)
Show SMILES OC1=C(CN(CCCC(F)(F)F)C1=O)C(=O)N[C@H]1CC[C@H](CC1)c1ccccc1
Show InChI InChI=1S/C21H25F3N2O3/c22-21(23,24)11-4-12-26-13-17(18(27)20(26)29)19(28)25-16-9-7-15(8-10-16)14-5-2-1-3-6-14/h1-3,5-6,15-16,27H,4,7-13H2,(H,25,28)/t15-,16+
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Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...


Citation and Details
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM254862
PNG
(US9493412, 104)
Show SMILES C[C@@H](NC(=O)C1=C(O)C(=O)N(C)C1)c1cccc(c1)-c1ccc(CNC(C)=O)cc1
Show InChI InChI=1S/C23H25N3O4/c1-14(25-22(29)20-13-26(3)23(30)21(20)28)18-5-4-6-19(11-18)17-9-7-16(8-10-17)12-24-15(2)27/h4-11,14,28H,12-13H2,1-3H3,(H,24,27)(H,25,29)/t14-/m1/s1
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n/an/a 254n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...


Citation and Details
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM254856
PNG
(US9493412, 83)
Show SMILES CN1CC(C(=O)NCc2cccc(c2)-c2ccc(CNS(C)(=O)=O)cc2)=C(O)C1=O
Show InChI InChI=1S/C21H23N3O5S/c1-24-13-18(19(25)21(24)27)20(26)22-11-15-4-3-5-17(10-15)16-8-6-14(7-9-16)12-23-30(2,28)29/h3-10,23,25H,11-13H2,1-2H3,(H,22,26)
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Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...


Citation and Details
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM254849
PNG
(US9493412, 22)
Show SMILES CN1CC(C(=O)NCc2ccc(OC3CCOCC3)cc2)=C(O)C1=O
Show InChI InChI=1S/C18H22N2O5/c1-20-11-15(16(21)18(20)23)17(22)19-10-12-2-4-13(5-3-12)25-14-6-8-24-9-7-14/h2-5,14,21H,6-11H2,1H3,(H,19,22)
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Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...


Citation and Details
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM254858
PNG
(US9493412, 91)
Show SMILES C[C@@H](NC(=O)C1=C(O)C(=O)N(C)C1)c1cccc(c1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C21H19F3N2O3/c1-12(25-19(28)17-11-26(2)20(29)18(17)27)13-5-3-6-14(9-13)15-7-4-8-16(10-15)21(22,23)24/h3-10,12,27H,11H2,1-2H3,(H,25,28)/t12-/m1/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...


Citation and Details
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM254860
PNG
(US9493412, 96)
Show SMILES C[C@@H](NC(=O)C1=C(O)C(=O)N(C)C1)c1cccc(c1)-c1cccc(c1)C#N
Show InChI InChI=1S/C21H19N3O3/c1-13(23-20(26)18-12-24(2)21(27)19(18)25)15-6-4-8-17(10-15)16-7-3-5-14(9-16)11-22/h3-10,13,25H,12H2,1-2H3,(H,23,26)/t13-/m1/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...


Citation and Details
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM254855
PNG
(US9493412, 66)
Show SMILES CN1CC(C(=O)NCc2cccc(c2)-c2cccc(c2)C(C)=O)=C(O)C1=O
Show InChI InChI=1S/C21H20N2O4/c1-13(24)15-6-4-8-17(10-15)16-7-3-5-14(9-16)11-22-20(26)18-12-23(2)21(27)19(18)25/h3-10,25H,11-12H2,1-2H3,(H,22,26)
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Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...


Citation and Details
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM254877
PNG
(US9493412, 214)
Show SMILES CCN1CC(C(=O)NCC2CCc3cnc(-c4ccc(Cl)c(Cl)c4)n3C2)=C(O)C1=O
Show InChI InChI=1S/C21H22Cl2N4O3/c1-2-26-11-15(18(28)21(26)30)20(29)25-8-12-3-5-14-9-24-19(27(14)10-12)13-4-6-16(22)17(23)7-13/h4,6-7,9,12,28H,2-3,5,8,10-11H2,1H3,(H,25,29)
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Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...


Citation and Details
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM254869
PNG
(US9493412, 179)
Show SMILES OC1=C(CN(C2CCN(CC2)c2ccc(F)cc2)C1=O)C(=O)N[C@H]1CC[C@H](CC1)c1ccccc1
Show InChI InChI=1S/C28H32FN3O3/c29-21-8-12-23(13-9-21)31-16-14-24(15-17-31)32-18-25(26(33)28(32)35)27(34)30-22-10-6-20(7-11-22)19-4-2-1-3-5-19/h1-5,8-9,12-13,20,22,24,33H,6-7,10-11,14-18H2,(H,30,34)/t20-,22+
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n/an/a 3.09E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...


Citation and Details
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM254867
PNG
(US9493412, 172)
Show SMILES OC1=C(CN(CCS(=O)(=O)c2ccccc2)C1=O)C(=O)N[C@H]1CC[C@H](CC1)c1ccccc1
Show InChI InChI=1S/C25H28N2O5S/c28-23-22(17-27(25(23)30)15-16-33(31,32)21-9-5-2-6-10-21)24(29)26-20-13-11-19(12-14-20)18-7-3-1-4-8-18/h1-10,19-20,28H,11-17H2,(H,26,29)/t19-,20+
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Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...


Citation and Details
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM254864
PNG
(US9493412, 157)
Show SMILES CN1CC(C(=O)NCC2CCN(CC2)C(=O)c2ccc(Cl)c(Cl)c2)=C(O)C1=O
Show InChI InChI=1S/C19H21Cl2N3O4/c1-23-10-13(16(25)19(23)28)17(26)22-9-11-4-6-24(7-5-11)18(27)12-2-3-14(20)15(21)8-12/h2-3,8,11,25H,4-7,9-10H2,1H3,(H,22,26)
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n/an/a 4.84E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...


Citation and Details
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM254870
PNG
(US9493412, 181)
Show SMILES CNCCCN1CC(C(=O)N[C@H]2CC[C@H](CC2)c2ccccc2)=C(O)C1=O
Show InChI InChI=1S/C21H29N3O3/c1-22-12-5-13-24-14-18(19(25)21(24)27)20(26)23-17-10-8-16(9-11-17)15-6-3-2-4-7-15/h2-4,6-7,16-17,22,25H,5,8-14H2,1H3,(H,23,26)/t16-,17+
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n/an/a 5.73E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...


Citation and Details
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM254872
PNG
(US9493412, 210)
Show SMILES CN(CCN1CC(C(=O)N[C@H]2CC[C@H](CC2)c2ccccc2)=C(O)C1=O)c1ccccc1
Show InChI InChI=1S/C26H31N3O3/c1-28(22-10-6-3-7-11-22)16-17-29-18-23(24(30)26(29)32)25(31)27-21-14-12-20(13-15-21)19-8-4-2-5-9-19/h2-11,20-21,30H,12-18H2,1H3,(H,27,31)/t20-,21+
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n/an/a 6.57E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...


Citation and Details
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM254866
PNG
(US9493412, 169)
Show SMILES OC1=C(CN(CCC(F)(F)C(F)(F)F)C1=O)C(=O)N[C@H]1CC[C@H](CC1)c1ccccc1
Show InChI InChI=1S/C21H23F5N2O3/c22-20(23,21(24,25)26)10-11-28-12-16(17(29)19(28)31)18(30)27-15-8-6-14(7-9-15)13-4-2-1-3-5-13/h1-5,14-15,29H,6-12H2,(H,27,30)/t14-,15+
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n/an/a 7.17E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...


Citation and Details
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM254871
PNG
(US9493412, 196)
Show SMILES CN1CC(CC1=O)N1CC(C(=O)N[C@H]2CC[C@H](CC2)c2ccccc2)=C(O)C1=O
Show InChI InChI=1S/C22H27N3O4/c1-24-12-17(11-19(24)26)25-13-18(20(27)22(25)29)21(28)23-16-9-7-15(8-10-16)14-5-3-2-4-6-14/h2-6,15-17,27H,7-13H2,1H3,(H,23,28)/t15-,16+,17?
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n/an/a 8.25E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...


Citation and Details
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM254873
PNG
(US9493412, 212)
Show SMILES OC1=C(N2CCCCC2C1=O)C(=O)N[C@H]1CC[C@H](CC1)c1ccccc1
Show InChI InChI=1S/C21H26N2O3/c24-19-17-8-4-5-13-23(17)18(20(19)25)21(26)22-16-11-9-15(10-12-16)14-6-2-1-3-7-14/h1-3,6-7,15-17,25H,4-5,8-13H2,(H,22,26)/t15-,16+,17?
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n/an/a 8.28E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...


Citation and Details
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM254868
PNG
(US9493412, 173)
Show SMILES CN1CC(C(=O)NC2CC[C@@H](C2)c2ccccc2)=C(O)C1=O
Show InChI InChI=1S/C17H20N2O3/c1-19-10-14(15(20)17(19)22)16(21)18-13-8-7-12(9-13)11-5-3-2-4-6-11/h2-6,12-13,20H,7-10H2,1H3,(H,18,21)/t12-,13?/m0/s1
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n/an/a 8.47E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...


Citation and Details
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM254850
PNG
(US9493412, 24)
Show SMILES CN1CC(C(=O)NCc2ccc(cc2)C(=O)N2CCCCC2)=C(O)C1=O
Show InChI InChI=1S/C19H23N3O4/c1-21-12-15(16(23)19(21)26)17(24)20-11-13-5-7-14(8-6-13)18(25)22-9-3-2-4-10-22/h5-8,23H,2-4,9-12H2,1H3,(H,20,24)
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n/an/a 9.30E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...


Citation and Details
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM254876
PNG
(US9493412, 178)
Show SMILES CN(CCN1CC(C(=O)N[C@H]2CC[C@H](CC2)c2ccccc2)=C(O)C1=O)C(=O)C=CC(F)(F)F
Show InChI InChI=1S/C24H28F3N3O4/c1-29(20(31)11-12-24(25,26)27)13-14-30-15-19(21(32)23(30)34)22(33)28-18-9-7-17(8-10-18)16-5-3-2-4-6-16/h2-6,11-12,17-18,32H,7-10,13-15H2,1H3,(H,28,33)/b12-11+/t17-,18+
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n/an/a 9.92E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase activity was measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artificial vesicle containing DMPG (Av...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%