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Patent code US9493440

Compile Data Set for Download or QSAR

Found 239 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM257380
PNG
(US9493440, 230)
Show SMILES CC1(CC1)Oc1ccc2[nH]nc(-c3cc(ncn3)N3CCN(CCF)CC3)c2c1
Show InChI InChI=1S/C21H25FN6O/c1-21(4-5-21)29-15-2-3-17-16(12-15)20(26-25-17)18-13-19(24-14-23-18)28-10-8-27(7-6-22)9-11-28/h2-3,12-14H,4-11H2,1H3,(H,25,26)
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UniChem
US Patent
n/an/a 0.450n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound (98 uM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well bla...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM257387
PNG
(US9493440, T2)
Show SMILES C[C@H]1CN(C[C@@H](C)N1C)c1cc(ncn1)-c1n[nH]c2ccc(OC3(C)CC3)cc12
Show InChI InChI=1S/C22H28N6O/c1-14-11-28(12-15(2)27(14)4)20-10-19(23-13-24-20)21-17-9-16(29-22(3)7-8-22)5-6-18(17)25-26-21/h5-6,9-10,13-15H,7-8,11-12H2,1-4H3,(H,25,26)/t14-,15+
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UniChem
US Patent
n/an/a 0.490n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound (98 uM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well bla...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM257316
PNG
(US9493440, 160)
Show SMILES COCCN1CCN(CC1)c1cc(ncn1)-c1n[nH]c2cc(F)c(OC3(C)CC3)cc12
Show InChI InChI=1S/C22H27FN6O2/c1-22(3-4-22)31-19-11-15-17(12-16(19)23)26-27-21(15)18-13-20(25-14-24-18)29-7-5-28(6-8-29)9-10-30-2/h11-14H,3-10H2,1-2H3,(H,26,27)
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US Patent
n/an/a<0.520n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound (98 uM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well bla...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM257342
PNG
(US9493440, 186)
Show SMILES CC1(CC1)Oc1cc2c(n[nH]c2cc1F)-c1cc(ncn1)N1CCS(=O)(=O)CC1
Show InChI InChI=1S/C19H20FN5O3S/c1-19(2-3-19)28-16-8-12-14(9-13(16)20)23-24-18(12)15-10-17(22-11-21-15)25-4-6-29(26,27)7-5-25/h8-11H,2-7H2,1H3,(H,23,24)
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US Patent
n/an/a 0.600n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound (98 uM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well bla...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM257330
PNG
(US9493440, 174)
Show SMILES Cc1nonc1N1CCN(CC1)c1cc(ncn1)-c1n[nH]c2cc(F)c(OC3(C)CC3)cc12
Show InChI InChI=1S/C22H23FN8O2/c1-13-21(29-33-28-13)31-7-5-30(6-8-31)19-11-17(24-12-25-19)20-14-9-18(32-22(2)3-4-22)15(23)10-16(14)26-27-20/h9-12H,3-8H2,1-2H3,(H,26,27)
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US Patent
n/an/a 0.600n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound (98 uM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well bla...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM257285
PNG
(US9493440, 129)
Show SMILES C[C@H]1CN(CCN1Cc1ncco1)c1cc(ncn1)-c1n[nH]c2ccc(OC3(C)CC3)cc12
Show InChI InChI=1S/C24H27N7O2/c1-16-13-31(9-8-30(16)14-22-25-7-10-32-22)21-12-20(26-15-27-21)23-18-11-17(33-24(2)5-6-24)3-4-19(18)28-29-23/h3-4,7,10-12,15-16H,5-6,8-9,13-14H2,1-2H3,(H,28,29)/t16-/m0/s1
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US Patent
n/an/a 0.600n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound (98 uM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well bla...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM257312
PNG
(US9493440, 156)
Show SMILES CN1CCN(CC1=O)c1cc(ncn1)-c1n[nH]c2cc(F)c(OC3(C)CC3)cc12
Show InChI InChI=1S/C20H21FN6O2/c1-20(3-4-20)29-16-7-12-14(8-13(16)21)24-25-19(12)15-9-17(23-11-22-15)27-6-5-26(2)18(28)10-27/h7-9,11H,3-6,10H2,1-2H3,(H,24,25)
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n/an/a<0.600n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound (98 uM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well bla...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM257175
PNG
(US9493440, 16)
Show SMILES C[C@@H]1CN(CCN1C)c1cc(ncn1)-c1n[nH]c2ccc(OC3(C)CC3)cc12
Show InChI InChI=1S/C21H26N6O/c1-14-12-27(9-8-26(14)3)19-11-18(22-13-23-19)20-16-10-15(28-21(2)6-7-21)4-5-17(16)24-25-20/h4-5,10-11,13-14H,6-9,12H2,1-3H3,(H,24,25)/t14-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound (98 uM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well bla...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM257309
PNG
(US9493440, 153)
Show SMILES CN1CCN(CC1)c1cc(ncn1)-c1n[nH]c2cc(F)c(OC3(C)CC3)cc12
Show InChI InChI=1S/C20H23FN6O/c1-20(3-4-20)28-17-9-13-15(10-14(17)21)24-25-19(13)16-11-18(23-12-22-16)27-7-5-26(2)6-8-27/h9-12H,3-8H2,1-2H3,(H,24,25)
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US Patent
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound (98 uM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well bla...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM257307
PNG
(US9493440, 151)
Show SMILES C[C@@H]1CN(CCO1)c1cc(ncn1)-c1n[nH]c2cc(F)c(OC3(C)CC3)cc12
Show InChI InChI=1S/C20H22FN5O2/c1-12-10-26(5-6-27-12)18-9-16(22-11-23-18)19-13-7-17(28-20(2)3-4-20)14(21)8-15(13)24-25-19/h7-9,11-12H,3-6,10H2,1-2H3,(H,24,25)/t12-/m1/s1
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US Patent
n/an/a<0.600n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound (98 uM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well bla...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM257326
PNG
(US9493440, 170)
Show SMILES CC1(CC1)Oc1cc2c(n[nH]c2cc1F)-c1cc(ncn1)N1CCS(=O)CC1
Show InChI InChI=1S/C19H20FN5O2S/c1-19(2-3-19)27-16-8-12-14(9-13(16)20)23-24-18(12)15-10-17(22-11-21-15)25-4-6-28(26)7-5-25/h8-11H,2-7H2,1H3,(H,23,24)
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US Patent
n/an/a 0.600n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound (98 uM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well bla...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM257184
PNG
(BDBM257386 | US9493440, 26)
Show SMILES C[C@H]1CN(CCN1C)c1cc(ncn1)-c1n[nH]c2ccc(OC3(C)CC3)cc12
Show InChI InChI=1S/C21H26N6O/c1-14-12-27(9-8-26(14)3)19-11-18(22-13-23-19)20-16-10-15(28-21(2)6-7-21)4-5-17(16)24-25-20/h4-5,10-11,13-14H,6-9,12H2,1-3H3,(H,24,25)/t14-/m0/s1
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US Patent
n/an/a 0.600n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound (98 uM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well bla...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM257295
PNG
(US9493440, 139)
Show SMILES COCC(C)N1CCN(C[C@H]1C)c1cc(ncn1)-c1n[nH]c2ccc(OC3(C)CC3)cc12
Show InChI InChI=1S/C24H32N6O2/c1-16-13-29(9-10-30(16)17(2)14-31-4)22-12-21(25-15-26-22)23-19-11-18(32-24(3)7-8-24)5-6-20(19)27-28-23/h5-6,11-12,15-17H,7-10,13-14H2,1-4H3,(H,27,28)/t16-,17?/m1/s1
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US Patent
n/an/a 0.600n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound (98 uM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well bla...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM257287
PNG
(US9493440, 131)
Show SMILES COCC(C)N1CCN(C[C@@H]1C)c1cc(ncn1)-c1n[nH]c2ccc(OC3(C)CC3)cc12
Show InChI InChI=1S/C24H32N6O2/c1-16-13-29(9-10-30(16)17(2)14-31-4)22-12-21(25-15-26-22)23-19-11-18(32-24(3)7-8-24)5-6-20(19)27-28-23/h5-6,11-12,15-17H,7-10,13-14H2,1-4H3,(H,27,28)/t16-,17?/m0/s1
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PC sid
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US Patent
n/an/a 0.600n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound (98 uM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well bla...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM257194
PNG
(US9493440, 38)
Show SMILES CC1(CC1)Oc1ccc2[nH]nc(-c3cc(ncn3)N3CCC4(CNC(=O)C4)CC3)c2c1
Show InChI InChI=1S/C23H26N6O2/c1-22(4-5-22)31-15-2-3-17-16(10-15)21(28-27-17)18-11-19(26-14-25-18)29-8-6-23(7-9-29)12-20(30)24-13-23/h2-3,10-11,14H,4-9,12-13H2,1H3,(H,24,30)(H,27,28)
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n/an/a<0.600n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound (98 uM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well bla...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM257161
PNG
(BDBM257389 | US9493440, 1)
Show SMILES CC1(CC1)Oc1ccc2[nH]nc(-c3cc(ncn3)N3CCOCC3)c2c1
Show InChI InChI=1S/C19H21N5O2/c1-19(4-5-19)26-13-2-3-15-14(10-13)18(23-22-15)16-11-17(21-12-20-16)24-6-8-25-9-7-24/h2-3,10-12H,4-9H2,1H3,(H,22,23)
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PC sid
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US Patent
n/an/a 0.600n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound (98 uM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well bla...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM257289
PNG
(US9493440, 133)
Show SMILES CCN1CCN(C[C@@H]1C)c1cc(ncn1)-c1n[nH]c2ccc(OC3(C)CC3)cc12
Show InChI InChI=1S/C22H28N6O/c1-4-27-9-10-28(13-15(27)2)20-12-19(23-14-24-20)21-17-11-16(29-22(3)7-8-22)5-6-18(17)25-26-21/h5-6,11-12,14-15H,4,7-10,13H2,1-3H3,(H,25,26)/t15-/m0/s1
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US Patent
n/an/a 0.600n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound (98 uM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well bla...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM257311
PNG
(US9493440, 155)
Show SMILES CC1(CC1)Oc1cc2c(n[nH]c2cc1F)-c1cc(ncn1)N1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C20H23FN6O3S/c1-20(3-4-20)30-17-9-13-15(10-14(17)21)24-25-19(13)16-11-18(23-12-22-16)26-5-7-27(8-6-26)31(2,28)29/h9-12H,3-8H2,1-2H3,(H,24,25)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound (98 uM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well bla...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM257184
PNG
(BDBM257386 | US9493440, 26)
Show SMILES C[C@H]1CN(CCN1C)c1cc(ncn1)-c1n[nH]c2ccc(OC3(C)CC3)cc12
Show InChI InChI=1S/C21H26N6O/c1-14-12-27(9-8-26(14)3)19-11-18(22-13-23-19)20-16-10-15(28-21(2)6-7-21)4-5-17(16)24-25-20/h4-5,10-11,13-14H,6-9,12H2,1-3H3,(H,24,25)/t14-/m0/s1
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US Patent
n/an/a<0.600n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound (98 uM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well bla...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM257189
PNG
(BDBM257192 | US9493440, 33)
Show SMILES CCS(=O)(=O)N1CCN(CC1)c1cc(ncn1)-c1n[nH]c2ccc(OC3(C)CC3)cc12
Show InChI InChI=1S/C21H26N6O3S/c1-3-31(28,29)27-10-8-26(9-11-27)19-13-18(22-14-23-19)20-16-12-15(30-21(2)6-7-21)4-5-17(16)24-25-20/h4-5,12-14H,3,6-11H2,1-2H3,(H,24,25)
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PC sid
UniChem
US Patent
n/an/a 0.630n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound (98 uM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well bla...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM257189
PNG
(BDBM257192 | US9493440, 33)
Show SMILES CCS(=O)(=O)N1CCN(CC1)c1cc(ncn1)-c1n[nH]c2ccc(OC3(C)CC3)cc12
Show InChI InChI=1S/C21H26N6O3S/c1-3-31(28,29)27-10-8-26(9-11-27)19-13-18(22-14-23-19)20-16-12-15(30-21(2)6-7-21)4-5-17(16)24-25-20/h4-5,12-14H,3,6-11H2,1-2H3,(H,24,25)
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PC cid
PC sid
UniChem
US Patent
n/an/a 0.630n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound (98 uM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well bla...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM257315
PNG
(US9493440, 159)
Show SMILES CC1(CC1)Oc1cc2c(n[nH]c2cc1F)-c1cc(ncn1)N1CCN(CCF)CC1
Show InChI InChI=1S/C21H24F2N6O/c1-21(2-3-21)30-18-10-14-16(11-15(18)23)26-27-20(14)17-12-19(25-13-24-17)29-8-6-28(5-4-22)7-9-29/h10-13H,2-9H2,1H3,(H,26,27)
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n/an/a 0.670n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound (98 uM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well bla...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM257371
PNG
(US9493440, 219)
Show SMILES CCC1(CC1)Oc1ccc2[nH]nc(-c3cc(ncn3)N3CCN(CC3)S(C)(=O)=O)c2c1
Show InChI InChI=1S/C21H26N6O3S/c1-3-21(6-7-21)30-15-4-5-17-16(12-15)20(25-24-17)18-13-19(23-14-22-18)26-8-10-27(11-9-26)31(2,28)29/h4-5,12-14H,3,6-11H2,1-2H3,(H,24,25)
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n/an/a 0.670n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound (98 uM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well bla...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM257292
PNG
(US9493440, 136)
Show SMILES C[C@@H]1CN(CCN1Cc1cocn1)c1cc(ncn1)-c1n[nH]c2ccc(OC3(C)CC3)cc12
Show InChI InChI=1S/C24H27N7O2/c1-16-11-31(8-7-30(16)12-17-13-32-15-27-17)22-10-21(25-14-26-22)23-19-9-18(33-24(2)5-6-24)3-4-20(19)28-29-23/h3-4,9-10,13-16H,5-8,11-12H2,1-2H3,(H,28,29)/t16-/m1/s1
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n/an/a 0.700n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound (98 uM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well bla...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM257286
PNG
(US9493440, 130)
Show SMILES C[C@H]1CN(CCN1Cc1cocn1)c1cc(ncn1)-c1n[nH]c2ccc(OC3(C)CC3)cc12
Show InChI InChI=1S/C24H27N7O2/c1-16-11-31(8-7-30(16)12-17-13-32-15-27-17)22-10-21(25-14-26-22)23-19-9-18(33-24(2)5-6-24)3-4-20(19)28-29-23/h3-4,9-10,13-16H,5-8,11-12H2,1-2H3,(H,28,29)/t16-/m0/s1
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n/an/a 0.700n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound (98 uM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well bla...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM257271
PNG
(US9493440, 115)
Show SMILES CC1(CC1)Oc1ccc2[nH]nc(-c3cc(ncn3)N3CCN(CC4CCCO4)CC3)c2c1
Show InChI InChI=1S/C24H30N6O2/c1-24(6-7-24)32-17-4-5-20-19(13-17)23(28-27-20)21-14-22(26-16-25-21)30-10-8-29(9-11-30)15-18-3-2-12-31-18/h4-5,13-14,16,18H,2-3,6-12,15H2,1H3,(H,27,28)
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n/an/a 0.700n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound (98 uM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well bla...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM257193
PNG
(US9493440, 37)
Show SMILES CN1CC2(CC1=O)CCN(CC2)c1cc(ncn1)-c1n[nH]c2ccc(OC3(C)CC3)cc12
Show InChI InChI=1S/C24H28N6O2/c1-23(5-6-23)32-16-3-4-18-17(11-16)22(28-27-18)19-12-20(26-15-25-19)30-9-7-24(8-10-30)13-21(31)29(2)14-24/h3-4,11-12,15H,5-10,13-14H2,1-2H3,(H,27,28)
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n/an/a 0.700n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound (98 uM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well bla...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM257336
PNG
(US9493440, 180)
Show SMILES CC1(CC1)Oc1cc2c(n[nH]c2cc1F)-c1cc(ncn1)N1CCN(CC1)c1nncs1
Show InChI InChI=1S/C21H21FN8OS/c1-21(2-3-21)31-17-8-13-15(9-14(17)22)26-27-19(13)16-10-18(24-11-23-16)29-4-6-30(7-5-29)20-28-25-12-32-20/h8-12H,2-7H2,1H3,(H,26,27)
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n/an/a 0.700n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound (98 uM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well bla...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM257332
PNG
(US9493440, 176)
Show SMILES CC1(CC1)Oc1cc2c(n[nH]c2cc1F)-c1cc(ncn1)N1CCN(CC2CCCO2)CC1
Show InChI InChI=1S/C24H29FN6O2/c1-24(4-5-24)33-21-11-17-19(12-18(21)25)28-29-23(17)20-13-22(27-15-26-20)31-8-6-30(7-9-31)14-16-3-2-10-32-16/h11-13,15-16H,2-10,14H2,1H3,(H,28,29)
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n/an/a 0.700n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound (98 uM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well bla...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM257284
PNG
(US9493440, 128)
Show SMILES C[C@H]1CN(CCN1Cc1ccco1)c1cc(ncn1)-c1n[nH]c2ccc(OC3(C)CC3)cc12
Show InChI InChI=1S/C25H28N6O2/c1-17-14-31(10-9-30(17)15-19-4-3-11-32-19)23-13-22(26-16-27-23)24-20-12-18(33-25(2)7-8-25)5-6-21(20)28-29-24/h3-6,11-13,16-17H,7-10,14-15H2,1-2H3,(H,28,29)/t17-/m0/s1
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n/an/a 0.700n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound (98 uM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well bla...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM257305
PNG
(US9493440, 149)
Show SMILES CC1(CC1)Oc1cc2c(n[nH]c2cc1F)-c1cc(ncn1)N1CCOCC1
Show InChI InChI=1S/C19H20FN5O2/c1-19(2-3-19)27-16-8-12-14(9-13(16)20)23-24-18(12)15-10-17(22-11-21-15)25-4-6-26-7-5-25/h8-11H,2-7H2,1H3,(H,23,24)
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n/an/a 0.710n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound (98 uM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well bla...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM257195
PNG
(US9493440, 39)
Show SMILES CN1CCC2(CCN(CC2)c2cc(ncn2)-c2n[nH]c3ccc(OC4(C)CC4)cc23)C1=O
Show InChI InChI=1S/C24H28N6O2/c1-23(5-6-23)32-16-3-4-18-17(13-16)21(28-27-18)19-14-20(26-15-25-19)30-11-8-24(9-12-30)7-10-29(2)22(24)31/h3-4,13-15H,5-12H2,1-2H3,(H,27,28)
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n/an/a 0.710n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound (98 uM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well bla...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM257381
PNG
(US9493440, 231)
Show SMILES CC1(CC1)Oc1ccc2[nH]nc(-c3cc(ncn3)N3CCN(CCO)C(=O)C3)c2c1
Show InChI InChI=1S/C21H24N6O3/c1-21(4-5-21)30-14-2-3-16-15(10-14)20(25-24-16)17-11-18(23-13-22-17)27-7-6-26(8-9-28)19(29)12-27/h2-3,10-11,13,28H,4-9,12H2,1H3,(H,24,25)
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n/an/a 0.730n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound (98 uM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well bla...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM257181
PNG
(BDBM257382 | US9493440, 23)
Show SMILES CC1(CC1)Oc1ccc2[nH]nc(-c3cc(ncn3)N3CCO[C@@H](CO)C3)c2c1
Show InChI InChI=1S/C20H23N5O3/c1-20(4-5-20)28-13-2-3-16-15(8-13)19(24-23-16)17-9-18(22-12-21-17)25-6-7-27-14(10-25)11-26/h2-3,8-9,12,14,26H,4-7,10-11H2,1H3,(H,23,24)/t14-/m1/s1
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n/an/a 0.75n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound (98 uM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well bla...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM257181
PNG
(BDBM257382 | US9493440, 23)
Show SMILES CC1(CC1)Oc1ccc2[nH]nc(-c3cc(ncn3)N3CCO[C@@H](CO)C3)c2c1
Show InChI InChI=1S/C20H23N5O3/c1-20(4-5-20)28-13-2-3-16-15(8-13)19(24-23-16)17-9-18(22-12-21-17)25-6-7-27-14(10-25)11-26/h2-3,8-9,12,14,26H,4-7,10-11H2,1H3,(H,23,24)/t14-/m1/s1
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n/an/a 0.75n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound (98 uM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well bla...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM257182
PNG
(BDBM257383 | US9493440, 24)
Show SMILES CC1(CC1)Oc1ccc2[nH]nc(-c3cc(ncn3)N3CCO[C@H](CO)C3)c2c1
Show InChI InChI=1S/C20H23N5O3/c1-20(4-5-20)28-13-2-3-16-15(8-13)19(24-23-16)17-9-18(22-12-21-17)25-6-7-27-14(10-25)11-26/h2-3,8-9,12,14,26H,4-7,10-11H2,1H3,(H,23,24)/t14-/m0/s1
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n/an/a 0.780n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound (98 uM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well bla...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM257182
PNG
(BDBM257383 | US9493440, 24)
Show SMILES CC1(CC1)Oc1ccc2[nH]nc(-c3cc(ncn3)N3CCO[C@H](CO)C3)c2c1
Show InChI InChI=1S/C20H23N5O3/c1-20(4-5-20)28-13-2-3-16-15(8-13)19(24-23-16)17-9-18(22-12-21-17)25-6-7-27-14(10-25)11-26/h2-3,8-9,12,14,26H,4-7,10-11H2,1H3,(H,23,24)/t14-/m0/s1
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n/an/a 0.780n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound (98 uM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well bla...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM257306
PNG
(US9493440, 150)
Show SMILES C[C@H]1CN(C[C@@H](C)O1)c1cc(ncn1)-c1n[nH]c2cc(F)c(OC3(C)CC3)cc12
Show InChI InChI=1S/C21H24FN5O2/c1-12-9-27(10-13(2)28-12)19-8-17(23-11-24-19)20-14-6-18(29-21(3)4-5-21)15(22)7-16(14)25-26-20/h6-8,11-13H,4-5,9-10H2,1-3H3,(H,25,26)/t12-,13+
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n/an/a 0.790n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound (98 uM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well bla...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM257378
PNG
(US9493440, 228)
Show SMILES CC1(CC1)Oc1ccc2[nH]nc(-c3cc(ncn3)N3CCC(O)CC3)c2c1
Show InChI InChI=1S/C20H23N5O2/c1-20(6-7-20)27-14-2-3-16-15(10-14)19(24-23-16)17-11-18(22-12-21-17)25-8-4-13(26)5-9-25/h2-3,10-13,26H,4-9H2,1H3,(H,23,24)
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n/an/a 0.790n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound (98 uM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well bla...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM257261
PNG
(US9493440, 105)
Show SMILES COCC1CN(CCO1)c1cc(ncn1)-c1n[nH]c2ccc(OC3(C)CC3)cc12
Show InChI InChI=1S/C21H25N5O3/c1-21(5-6-21)29-14-3-4-17-16(9-14)20(25-24-17)18-10-19(23-13-22-18)26-7-8-28-15(11-26)12-27-2/h3-4,9-10,13,15H,5-8,11-12H2,1-2H3,(H,24,25)
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n/an/a 0.800n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound (98 uM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well bla...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM257322
PNG
(US9493440, 166)
Show SMILES CC1(CC1)Oc1cc2c(n[nH]c2cc1F)-c1cc(ncn1)N1CCN(CC1)C1CCS(=O)(=O)C1
Show InChI InChI=1S/C23H27FN6O3S/c1-23(3-4-23)33-20-10-16-18(11-17(20)24)27-28-22(16)19-12-21(26-14-25-19)30-7-5-29(6-8-30)15-2-9-34(31,32)13-15/h10-12,14-15H,2-9,13H2,1H3,(H,27,28)
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n/an/a 0.800n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound (98 uM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well bla...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM257351
PNG
(US9493440, 195)
Show SMILES COCC(=O)N1CCN(CC1)c1cc(ncn1)-c1n[nH]c2cc(F)c(OC3(C)CC3)cc12
Show InChI InChI=1S/C22H25FN6O3/c1-22(3-4-22)32-18-9-14-16(10-15(18)23)26-27-21(14)17-11-19(25-13-24-17)28-5-7-29(8-6-28)20(30)12-31-2/h9-11,13H,3-8,12H2,1-2H3,(H,26,27)
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n/an/a 0.800n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound (98 uM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well bla...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM257300
PNG
(US9493440, 144)
Show SMILES CC(C)N1CCN(C[C@H]1C)c1cc(ncn1)-c1n[nH]c2ccc(OC3(C)CC3)cc12
Show InChI InChI=1S/C23H30N6O/c1-15(2)29-10-9-28(13-16(29)3)21-12-20(24-14-25-21)22-18-11-17(30-23(4)7-8-23)5-6-19(18)26-27-22/h5-6,11-12,14-16H,7-10,13H2,1-4H3,(H,26,27)/t16-/m1/s1
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n/an/a 0.800n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound (98 uM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well bla...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM257298
PNG
(US9493440, 142)
Show SMILES CCN1CCN(C[C@H]1C)c1cc(ncn1)-c1n[nH]c2ccc(OC3(C)CC3)cc12
Show InChI InChI=1S/C22H28N6O/c1-4-27-9-10-28(13-15(27)2)20-12-19(23-14-24-20)21-17-11-16(29-22(3)7-8-22)5-6-18(17)25-26-21/h5-6,11-12,14-15H,4,7-10,13H2,1-3H3,(H,25,26)/t15-/m1/s1
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PC cid
PC sid
UniChem
US Patent
n/an/a 0.800n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound (98 uM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well bla...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM257290
PNG
(US9493440, 134)
Show SMILES C[C@H]1CN(CCN1CCC(F)(F)F)c1cc(ncn1)-c1n[nH]c2ccc(OC3(C)CC3)cc12
Show InChI InChI=1S/C23H27F3N6O/c1-15-13-32(10-9-31(15)8-7-23(24,25)26)20-12-19(27-14-28-20)21-17-11-16(33-22(2)5-6-22)3-4-18(17)29-30-21/h3-4,11-12,14-15H,5-10,13H2,1-2H3,(H,29,30)/t15-/m0/s1
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PC sid
UniChem
US Patent
n/an/a 0.800n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound (98 uM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well bla...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM257256
PNG
(US9493440, 100)
Show SMILES CC1(CC1)Oc1ccc2[nH]nc(-c3cc(ncn3)N3CCN(CC3)C3CCS(=O)(=O)C3)c2c1
Show InChI InChI=1S/C23H28N6O3S/c1-23(5-6-23)32-17-2-3-19-18(12-17)22(27-26-19)20-13-21(25-15-24-20)29-9-7-28(8-10-29)16-4-11-33(30,31)14-16/h2-3,12-13,15-16H,4-11,14H2,1H3,(H,26,27)
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PC sid
UniChem
US Patent
n/an/a 0.800n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound (98 uM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well bla...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM257174
PNG
(US9493440, 15)
Show SMILES CC1(CC1)Oc1ccc2[nH]nc(-c3cc(ncn3)N3CCC4(CCNC4=O)CC3)c2c1
Show InChI InChI=1S/C23H26N6O2/c1-22(4-5-22)31-15-2-3-17-16(12-15)20(28-27-17)18-13-19(26-14-25-18)29-10-7-23(8-11-29)6-9-24-21(23)30/h2-3,12-14H,4-11H2,1H3,(H,24,30)(H,27,28)
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UniChem
US Patent
n/an/a 0.860n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound (98 uM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well bla...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM257188
PNG
(US9493440, 32)
Show SMILES CC1(CC1)Oc1ccc2[nH]nc(-c3cc(ncn3)N3CCC4(CCC(=O)N4)CC3)c2c1
Show InChI InChI=1S/C23H26N6O2/c1-22(6-7-22)31-15-2-3-17-16(12-15)21(28-27-17)18-13-19(25-14-24-18)29-10-8-23(9-11-29)5-4-20(30)26-23/h2-3,12-14H,4-11H2,1H3,(H,26,30)(H,27,28)
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PC cid
PC sid
UniChem
US Patent
n/an/a 0.860n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound (98 uM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well bla...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM257197
PNG
(US9493440, 41)
Show SMILES CCC(=O)N1CCN(CC1)c1cc(ncn1)-c1n[nH]c2ccc(OC3(C)CC3)cc12
Show InChI InChI=1S/C22H26N6O2/c1-3-20(29)28-10-8-27(9-11-28)19-13-18(23-14-24-19)21-16-12-15(30-22(2)6-7-22)4-5-17(16)25-26-21/h4-5,12-14H,3,6-11H2,1-2H3,(H,25,26)
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PC sid
UniChem
US Patent
n/an/a 0.870n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound (98 uM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well bla...


Citation and Details
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)


(Homo sapiens (Human))
BDBM257353
PNG
(US9493440, 197)
Show SMILES CCC1(COC1)Oc1ccc2[nH]nc(-c3cc(ncn3)N3C[C@H](C)O[C@H](C)C3)c2c1
Show InChI InChI=1S/C22H27N5O3/c1-4-22(11-28-12-22)30-16-5-6-18-17(7-16)21(26-25-18)19-8-20(24-13-23-19)27-9-14(2)29-15(3)10-27/h5-8,13-15H,4,9-12H2,1-3H3,(H,25,26)/t14-,15+
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PC sid
UniChem
US Patent
n/an/a 0.890n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
a) 400 nl of a 1:2.15 serial dilution of test compound (98 uM top assay concentration) is spotted via Labcyte Echo to certain wells in a 384 well bla...


Citation and Details
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%