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Patent code US9493448

Compile Data Set for Download or QSAR
Found 168 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258159
PNG
(US9493448, 61)
Show SMILES CCc1cc(c(F)cc1O[C@H]1CCC[C@@H]1c1ccnn1C)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C21H24FN5O3S/c1-3-14-11-20(31(28,29)26-21-8-9-23-13-24-21)16(22)12-19(14)30-18-6-4-5-15(18)17-7-10-25-27(17)2/h7-13,15,18H,3-6H2,1-2H3,(H,23,24,26)/t15-,18+/m1/s1
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US Patent
n/an/a 2.60n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258109
PNG
(US9493448, 11)
Show SMILES Cn1nccc1[C@H]1CCC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C18H18F2N4O3S2/c1-24-14(5-6-22-24)11-3-2-4-15(11)27-16-7-13(20)17(8-12(16)19)29(25,26)23-18-9-28-10-21-18/h5-11,15,23H,2-4H2,1H3/t11-,15+/m1/s1
PDB

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n/an/a 10n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258102
PNG
(US9493448, 4)
Show SMILES Cn1nccc1[C@H]1CCCC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C18H19F2N5O3S2/c1-25-14(6-7-22-25)11-4-2-3-5-15(11)28-16-8-13(20)17(9-12(16)19)30(26,27)24-18-21-10-23-29-18/h6-11,15H,2-5H2,1H3,(H,21,23,24)/t11-,15+/m1/s1
PDB

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US Patent
n/an/a 12n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258107
PNG
(US9493448, 9)
Show SMILES Cn1nccc1[C@H]1CCCCC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C19H21F2N5O3S2/c1-26-15(7-8-23-26)12-5-3-2-4-6-16(12)29-17-9-14(21)18(10-13(17)20)31(27,28)25-19-22-11-24-30-19/h7-12,16H,2-6H2,1H3,(H,22,24,25)/t12-,16+/m1/s1
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n/an/a 14n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258219
PNG
(US9493448, 126)
Show SMILES Cc1cc(c(F)cc1O[C@H]1CCC(F)(F)C[C@@H]1c1ccnn1C)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C21H22F3N5O3S/c1-13-9-19(33(30,31)28-20-5-7-25-12-26-20)15(22)10-18(13)32-17-3-6-21(23,24)11-14(17)16-4-8-27-29(16)2/h4-5,7-10,12,14,17H,3,6,11H2,1-2H3,(H,25,26,28)/t14-,17+/m1/s1
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n/an/a 14n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258146
PNG
(US9493448, 122 | US9493448, 154 | US9493448, 48)
Show SMILES Cn1nccc1[C@H]1CCCC[C@@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H21ClFN5O3S/c1-27-16(6-9-25-27)13-4-2-3-5-17(13)30-18-11-15(22)19(10-14(18)21)31(28,29)26-20-7-8-23-12-24-20/h6-13,17H,2-5H2,1H3,(H,23,24,26)/t13-,17+/m1/s1
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n/an/a 16n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258106
PNG
(US9493448, 8)
Show SMILES Cn1nccc1[C@H]1CCC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C17H17F2N5O3S2/c1-24-13(5-6-21-24)10-3-2-4-14(10)27-15-7-12(19)16(8-11(15)18)29(25,26)23-17-20-9-22-28-17/h5-10,14H,2-4H2,1H3,(H,20,22,23)/t10-,14+/m1/s1
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n/an/a 17n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258164
PNG
(US9493448, 66)
Show SMILES Cc1c(O[C@H]2CCCC[C@@H]2c2ccnn2C)ccc(c1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C21H24FN5O3S/c1-14-17(30-18-6-4-3-5-15(18)16-9-12-25-27(16)2)7-8-19(21(14)22)31(28,29)26-20-10-11-23-13-24-20/h7-13,15,18H,3-6H2,1-2H3,(H,23,24,26)/t15-,18+/m1/s1
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n/an/a 17n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258146
PNG
(US9493448, 122 | US9493448, 154 | US9493448, 48)
Show SMILES Cn1nccc1[C@H]1CCCC[C@@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H21ClFN5O3S/c1-27-16(6-9-25-27)13-4-2-3-5-17(13)30-18-11-15(22)19(10-14(18)21)31(28,29)26-20-7-8-23-12-24-20/h6-13,17H,2-5H2,1H3,(H,23,24,26)/t13-,17+/m1/s1
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n/an/a 17n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258244
PNG
(US9493448, 152)
Show SMILES Fc1cc(O[C@H]2CC(F)(F)CC[C@@H]2c2cn[nH]c2)c(Cl)cc1S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C19H17ClF3N5O3S/c20-13-5-17(32(29,30)28-18-2-4-24-10-25-18)14(21)6-15(13)31-16-7-19(22,23)3-1-12(16)11-8-26-27-9-11/h2,4-6,8-10,12,16H,1,3,7H2,(H,26,27)(H,24,25,28)/t12-,16+/m1/s1
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n/an/a 17n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258231
PNG
(US9493448, 138 | US9493448, 148)
Show SMILES Cc1cc(c(F)cc1O[C@H]1CCC[C@@H]1c1ccn[nH]1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C19H20FN5O3S/c1-12-9-18(29(26,27)25-19-6-7-21-11-22-19)14(20)10-17(12)28-16-4-2-3-13(16)15-5-8-23-24-15/h5-11,13,16H,2-4H2,1H3,(H,23,24)(H,21,22,25)/t13-,16+/m1/s1
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n/an/a 18n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258146
PNG
(US9493448, 122 | US9493448, 154 | US9493448, 48)
Show SMILES Cn1nccc1[C@H]1CCCC[C@@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H21ClFN5O3S/c1-27-16(6-9-25-27)13-4-2-3-5-17(13)30-18-11-15(22)19(10-14(18)21)31(28,29)26-20-7-8-23-12-24-20/h6-13,17H,2-5H2,1H3,(H,23,24,26)/t13-,17+/m1/s1
PDB

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n/an/a 20n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258099
PNG
(US9493448, 1 | US9493448, 2 | US9493448, 3 | US949...)
Show SMILES Fc1cc(c(F)cc1O[C@H]1CCCC[C@@H]1c1ccccc1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H19F2N3O3S2/c21-15-11-19(30(26,27)25-20-23-12-24-29-20)16(22)10-18(15)28-17-9-5-4-8-14(17)13-6-2-1-3-7-13/h1-3,6-7,10-12,14,17H,4-5,8-9H2,(H,23,24,25)/t14-,17+/m1/s1
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n/an/a 20n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258220
PNG
(US9493448, 127 | US9493448, 143)
Show SMILES Cc1cc(c(F)cc1O[C@H]1CC(F)(F)CC[C@@H]1c1cn[nH]c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H20F3N5O3S/c1-12-6-18(32(29,30)28-19-3-5-24-11-25-19)15(21)7-16(12)31-17-8-20(22,23)4-2-14(17)13-9-26-27-10-13/h3,5-7,9-11,14,17H,2,4,8H2,1H3,(H,26,27)(H,24,25,28)/t14-,17+/m1/s1
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n/an/a 21n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258233
PNG
(US9493448, 140 | US9493448, 150)
Show SMILES Fc1cc(O[C@H]2CCC[C@@H]2c2ccn[nH]2)c(Cl)cc1S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C18H17ClFN5O3S/c19-12-8-17(29(26,27)25-18-5-6-21-10-22-18)13(20)9-16(12)28-15-3-1-2-11(15)14-4-7-23-24-14/h4-11,15H,1-3H2,(H,23,24)(H,21,22,25)/t11-,15+/m1/s1
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n/an/a 21n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258122
PNG
(US9493448, 24)
Show SMILES Cn1nccc1[C@H]1CCC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccnc(F)n1
Show InChI InChI=1S/C19H18F3N5O3S/c1-27-14(5-8-24-27)11-3-2-4-15(11)30-16-9-13(21)17(10-12(16)20)31(28,29)26-18-6-7-23-19(22)25-18/h5-11,15H,2-4H2,1H3,(H,23,25,26)/t11-,15+/m1/s1
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n/an/a 23n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258238
PNG
(US9493448, 146)
Show SMILES Cn1nccc1[C@H]1CC(F)(F)C[C@@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C19H17ClF3N5O3S/c1-28-14(2-5-26-28)11-8-19(22,23)9-16(11)31-15-7-13(21)17(6-12(15)20)32(29,30)27-18-3-4-24-10-25-18/h2-7,10-11,16H,8-9H2,1H3,(H,24,25,27)/t11-,16+/m1/s1
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n/an/a 24n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258231
PNG
(US9493448, 138 | US9493448, 148)
Show SMILES Cc1cc(c(F)cc1O[C@H]1CCC[C@@H]1c1ccn[nH]1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C19H20FN5O3S/c1-12-9-18(29(26,27)25-19-6-7-21-11-22-19)14(20)10-17(12)28-16-4-2-3-13(16)15-5-8-23-24-15/h5-11,13,16H,2-4H2,1H3,(H,23,24)(H,21,22,25)/t13-,16+/m1/s1
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n/an/a 24n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258141
PNG
(US9493448, 43)
Show SMILES Cc1cc(c(F)cc1O[C@H]1CCC[C@@H]1c1ccnn1C)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H22FN5O3S/c1-13-10-19(30(27,28)25-20-7-8-22-12-23-20)15(21)11-18(13)29-17-5-3-4-14(17)16-6-9-24-26(16)2/h6-12,14,17H,3-5H2,1-2H3,(H,22,23,25)/t14-,17+/m1/s1
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n/an/a 24n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258246
PNG
(US9493448, 155)
Show SMILES Cc1cc(c(F)cc1O[C@H]1CC(F)(F)CC[C@@H]1c1ccn[nH]1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H20F3N5O3S/c1-12-8-18(32(29,30)28-19-4-6-24-11-25-19)14(21)9-16(12)31-17-10-20(22,23)5-2-13(17)15-3-7-26-27-15/h3-4,6-9,11,13,17H,2,5,10H2,1H3,(H,26,27)(H,24,25,28)/t13-,17+/m1/s1
PDB

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n/an/a 28n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258161
PNG
(US9493448, 63)
Show SMILES Cn1nccc1[C@H]1CCCCC[C@@H]1Oc1cc(F)c(c(F)c1)S(=O)(=O)Nc1cc[nH]cn1
Show InChI InChI=1S/C21H23F2N5O3S/c1-28-18(7-10-26-28)15-5-3-2-4-6-19(15)31-14-11-16(22)21(17(23)12-14)32(29,30)27-20-8-9-24-13-25-20/h7-13,15,19H,2-6H2,1H3,(H,24,25,27)/t15-,19+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258249
PNG
(US9493448, 158)
Show SMILES Fc1cc(O[C@H]2CCCC[C@@H]2c2ccn[nH]2)c(Cl)cc1S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C19H19ClFN5O3S/c20-13-9-18(30(27,28)26-19-6-7-22-11-23-19)14(21)10-17(13)29-16-4-2-1-3-12(16)15-5-8-24-25-15/h5-12,16H,1-4H2,(H,24,25)(H,22,23,26)/t12-,16+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258113
PNG
(US9493448, 15)
Show SMILES Cn1nccc1[C@H]1CCC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C18H18F2N4O3S2/c1-24-14(5-6-22-24)11-3-2-4-15(11)27-16-9-13(20)17(10-12(16)19)29(25,26)23-18-21-7-8-28-18/h5-11,15H,2-4H2,1H3,(H,21,23)/t11-,15+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258103
PNG
(US9493448, 10 | US9493448, 5)
Show SMILES Cn1nccc1[C@H]1CCCC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C19H20F2N4O3S2/c1-25-15(6-7-23-25)12-4-2-3-5-16(12)28-17-8-14(21)18(9-13(17)20)30(26,27)24-19-10-29-11-22-19/h6-12,16,24H,2-5H2,1H3/t12-,16+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258185
PNG
(US9493448, 137 | US9493448, 90)
Show SMILES Cc1cc(c(F)cc1O[C@H]1CC(F)(F)CC[C@@H]1c1ccnn1C)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C21H22F3N5O3S/c1-13-9-19(33(30,31)28-20-5-7-25-12-26-20)15(22)10-17(13)32-18-11-21(23,24)6-3-14(18)16-4-8-27-29(16)2/h4-5,7-10,12,14,18H,3,6,11H2,1-2H3,(H,25,26,28)/t14-,18+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258144
PNG
(US9493448, 46)
Show SMILES Cn1nccc1[C@H]1CCCC[C@@H]1Oc1cc(F)c(c(F)c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H21F2N5O3S/c1-27-17(6-9-25-27)14-4-2-3-5-18(14)30-13-10-15(21)20(16(22)11-13)31(28,29)26-19-7-8-23-12-24-19/h6-12,14,18H,2-5H2,1H3,(H,23,24,26)/t14-,18+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258205
PNG
(US9493448, 111)
Show SMILES Cn1nccc1[C@H]1CCC[C@@H]1Oc1cc(F)c(c(F)c1)S(=O)(=O)Nc1ccnc(F)n1
Show InChI InChI=1S/C19H18F3N5O3S/c1-27-15(5-8-24-27)12-3-2-4-16(12)30-11-9-13(20)18(14(21)10-11)31(28,29)26-17-6-7-23-19(22)25-17/h5-10,12,16H,2-4H2,1H3,(H,23,25,26)/t12-,16+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258162
PNG
(US9493448, 64)
Show SMILES Cc1cc(c(F)cc1O[C@H]1CCCC[C@@H]1c1ccnn1C)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C21H24FN5O3S/c1-14-11-20(31(28,29)26-21-8-9-23-13-24-21)16(22)12-19(14)30-18-6-4-3-5-15(18)17-7-10-25-27(17)2/h7-13,15,18H,3-6H2,1-2H3,(H,23,24,26)/t15-,18+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258157
PNG
(US9493448, 59)
Show SMILES CCn1nccc1[C@H]1CCCC[C@@H]1Oc1cc(F)c(c(F)c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C21H23F2N5O3S/c1-2-28-18(7-10-26-28)15-5-3-4-6-19(15)31-14-11-16(22)21(17(23)12-14)32(29,30)27-20-8-9-24-13-25-20/h7-13,15,19H,2-6H2,1H3,(H,24,25,27)/t15-,19+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258191
PNG
(US9493448, 97)
Show SMILES Cn1nccc1[C@H]1C[C@H](C[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1)OCc1ccccc1
Show InChI InChI=1S/C26H25F2N5O4S/c1-33-22(7-10-31-33)19-11-18(36-15-17-5-3-2-4-6-17)12-23(19)37-24-13-21(28)25(14-20(24)27)38(34,35)32-26-8-9-29-16-30-26/h2-10,13-14,16,18-19,23H,11-12,15H2,1H3,(H,29,30,32)/t18-,19-,23+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258227
PNG
(US9493448, 134)
Show SMILES Cn1nccc1[C@H]1CCC(F)(F)C[C@@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1nncs1
Show InChI InChI=1S/C18H17ClF3N5O3S2/c1-27-13(3-5-24-27)10-2-4-18(21,22)8-15(10)30-14-7-12(20)16(6-11(14)19)32(28,29)26-17-25-23-9-31-17/h3,5-7,9-10,15H,2,4,8H2,1H3,(H,25,26)/t10-,15+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258233
PNG
(US9493448, 140 | US9493448, 150)
Show SMILES Fc1cc(O[C@H]2CCC[C@@H]2c2ccn[nH]2)c(Cl)cc1S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C18H17ClFN5O3S/c19-12-8-17(29(26,27)25-18-5-6-21-10-22-18)13(20)9-16(12)28-15-3-1-2-11(15)14-4-7-23-24-14/h4-11,15H,1-3H2,(H,23,24)(H,21,22,25)/t11-,15+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258176
PNG
(US9493448, 172 | US9493448, 81)
Show SMILES Cc1cc(c(F)cc1O[C@H]1CCCC[C@@H]1c1cn[nH]c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H22FN5O3S/c1-13-8-19(30(27,28)26-20-6-7-22-12-23-20)16(21)9-18(13)29-17-5-3-2-4-15(17)14-10-24-25-11-14/h6-12,15,17H,2-5H2,1H3,(H,24,25)(H,22,23,26)/t15-,17+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258232
PNG
(US9493448, 139)
Show SMILES Fc1cc(O[C@H]2CCC[C@@H]2c2ccn[nH]2)cc(F)c1S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C18H17F2N5O3S/c19-13-8-11(28-16-3-1-2-12(16)15-4-7-23-24-15)9-14(20)18(13)29(26,27)25-17-5-6-21-10-22-17/h4-10,12,16H,1-3H2,(H,23,24)(H,21,22,25)/t12-,16+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258181
PNG
(US9493448, 86)
Show SMILES Cn1nccc1[C@H]1CCCC[C@@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1nncs1
Show InChI InChI=1S/C18H19ClFN5O3S2/c1-25-14(6-7-22-25)11-4-2-3-5-15(11)28-16-9-13(20)17(8-12(16)19)30(26,27)24-18-23-21-10-29-18/h6-11,15H,2-5H2,1H3,(H,23,24)/t11-,15+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258179
PNG
(US9493448, 84)
Show SMILES Cc1c(O[C@H]2CC(F)(F)CC[C@@H]2c2ccnn2C)ccc(c1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C21H22F3N5O3S/c1-13-16(3-4-18(20(13)22)33(30,31)28-19-7-9-25-12-26-19)32-17-11-21(23,24)8-5-14(17)15-6-10-27-29(15)2/h3-4,6-7,9-10,12,14,17H,5,8,11H2,1-2H3,(H,25,26,28)/t14-,17+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258145
PNG
(US9493448, 102 | US9493448, 47)
Show SMILES Cn1nccc1[C@H]1CCC(F)(F)C[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H19F4N5O3S/c1-29-15(3-7-27-29)12-2-5-20(23,24)10-17(12)32-16-8-14(22)18(9-13(16)21)33(30,31)28-19-4-6-25-11-26-19/h3-4,6-9,11-12,17H,2,5,10H2,1H3,(H,25,26,28)/t12-,17+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258170
PNG
(US9493448, 72)
Show SMILES Cn1nccc1[C@H]1CCC(C)(C)C[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C22H25F2N5O3S/c1-22(2)7-4-14(17-5-9-27-29(17)3)19(12-22)32-18-10-16(24)20(11-15(18)23)33(30,31)28-21-6-8-25-13-26-21/h5-6,8-11,13-14,19H,4,7,12H2,1-3H3,(H,25,26,28)/t14-,19+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258158
PNG
(US9493448, 60)
Show SMILES Cn1nccc1[C@H]1CCCCC[C@@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C21H23ClFN5O3S/c1-28-17(7-10-26-28)14-5-3-2-4-6-18(14)31-19-12-16(23)20(11-15(19)22)32(29,30)27-21-8-9-24-13-25-21/h7-14,18H,2-6H2,1H3,(H,24,25,27)/t14-,18+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258152
PNG
(US9493448, 54)
Show SMILES Cc1cc(ccc1O[C@H]1CCCC[C@@H]1c1ccnn1C)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C21H25N5O3S/c1-15-13-16(30(27,28)25-21-10-11-22-14-23-21)7-8-19(15)29-20-6-4-3-5-17(20)18-9-12-24-26(18)2/h7-14,17,20H,3-6H2,1-2H3,(H,22,23,25)/t17-,20+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258153
PNG
(US9493448, 55)
Show SMILES Cn1nccc1[C@H]1CCCCC[C@@H]1Oc1ccc(cc1C#N)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C22H24N6O3S/c1-28-19(9-12-26-28)18-5-3-2-4-6-21(18)31-20-8-7-17(13-16(20)14-23)32(29,30)27-22-10-11-24-15-25-22/h7-13,15,18,21H,2-6H2,1H3,(H,24,25,27)/t18-,21+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258252
PNG
(US9493448, 161 | US9493448, 165)
Show SMILES Cn1nccc1[C@H]1C[C@H](O)CC[C@@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H21ClFN5O4S/c1-27-16(4-7-25-27)13-8-12(28)2-3-17(13)31-18-10-15(22)19(9-14(18)21)32(29,30)26-20-5-6-23-11-24-20/h4-7,9-13,17,28H,2-3,8H2,1H3,(H,23,24,26)/t12-,13-,17+/m1/s1
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n/an/a 40n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


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More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258247
PNG
(US9493448, 156)
Show SMILES Fc1cc(O[C@H]2CC(F)(F)CC[C@@H]2c2ccn[nH]2)c(Cl)cc1S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C19H17ClF3N5O3S/c20-12-7-17(32(29,30)28-18-3-5-24-10-25-18)13(21)8-15(12)31-16-9-19(22,23)4-1-11(16)14-2-6-26-27-14/h2-3,5-8,10-11,16H,1,4,9H2,(H,26,27)(H,24,25,28)/t11-,16+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258201
PNG
(US9493448, 107)
Show SMILES Cn1nccc1[C@H]1CC(F)(F)C[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C19H17F4N5O3S/c1-28-14(2-5-26-28)11-8-19(22,23)9-16(11)31-15-6-13(21)17(7-12(15)20)32(29,30)27-18-3-4-24-10-25-18/h2-7,10-11,16H,8-9H2,1H3,(H,24,25,27)/t11-,16+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


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More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258189
PNG
(US9493448, 171 | US9493448, 94)
Show SMILES Fc1cc(O[C@H]2CCCC[C@@H]2c2cn[nH]c2)cc(F)c1S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C19H19F2N5O3S/c20-15-7-13(29-17-4-2-1-3-14(17)12-9-24-25-10-12)8-16(21)19(15)30(27,28)26-18-5-6-22-11-23-18/h5-11,14,17H,1-4H2,(H,24,25)(H,22,23,26)/t14-,17+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258125
PNG
(US9493448, 27)
Show SMILES Cn1nccc1[C@H]1CCC[C@@H]1Oc1cc(F)c(c(F)c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C19H19F2N5O3S/c1-26-16(5-8-24-26)13-3-2-4-17(13)29-12-9-14(20)19(15(21)10-12)30(27,28)25-18-6-7-22-11-23-18/h5-11,13,17H,2-4H2,1H3,(H,22,23,25)/t13-,17+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258165
PNG
(US9493448, 67)
Show SMILES Cn1nccc1[C@H]1CC(C)(C)CC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C22H25F2N5O3S/c1-22(2)7-4-18(14(12-22)17-5-9-27-29(17)3)32-19-10-16(24)20(11-15(19)23)33(30,31)28-21-6-8-25-13-26-21/h5-6,8-11,13-14,18H,4,7,12H2,1-3H3,(H,25,26,28)/t14-,18+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258118
PNG
(US9493448, 20)
Show SMILES Cn1nccc1[C@H]1CCC[C@@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C19H19ClFN5O3S/c1-26-15(5-8-24-26)12-3-2-4-16(12)29-17-10-14(21)18(9-13(17)20)30(27,28)25-19-6-7-22-11-23-19/h5-12,16H,2-4H2,1H3,(H,22,23,25)/t12-,16+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


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More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258192
PNG
(US9493448, 98)
Show SMILES Cn1nccc1[C@H]1C[C@@H](C[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1)OCc1ccccc1
Show InChI InChI=1S/C26H25F2N5O4S/c1-33-22(7-10-31-33)19-11-18(36-15-17-5-3-2-4-6-17)12-23(19)37-24-13-21(28)25(14-20(24)27)38(34,35)32-26-8-9-29-16-30-26/h2-10,13-14,16,18-19,23H,11-12,15H2,1H3,(H,29,30,32)/t18-,19+,23-/m0/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258126
PNG
(US9493448, 28)
Show SMILES CCn1nccc1[C@H]1CCCC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C21H23F2N5O3S/c1-2-28-17(7-10-26-28)14-5-3-4-6-18(14)31-19-11-16(23)20(12-15(19)22)32(29,30)27-21-8-9-24-13-25-21/h7-14,18H,2-6H2,1H3,(H,24,25,27)/t14-,18+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258148
PNG
(US9493448, 50)
Show SMILES CCn1nccc1[C@H]1CCC[C@@H]1Oc1cc(F)c(c(F)c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H21F2N5O3S/c1-2-27-17(6-9-25-27)14-4-3-5-18(14)30-13-10-15(21)20(16(22)11-13)31(28,29)26-19-7-8-23-12-24-19/h6-12,14,18H,2-5H2,1H3,(H,23,24,26)/t14-,18+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258203
PNG
(US9493448, 109)
Show SMILES Cn1nccc1[C@H]1CCC(F)(F)C[C@@H]1Oc1cc(F)c(c(F)c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H19F4N5O3S/c1-29-16(3-7-27-29)13-2-5-20(23,24)10-17(13)32-12-8-14(21)19(15(22)9-12)33(30,31)28-18-4-6-25-11-26-18/h3-4,6-9,11,13,17H,2,5,10H2,1H3,(H,25,26,28)/t13-,17+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258248
PNG
(US9493448, 157)
Show SMILES Cc1cc(c(F)cc1O[C@H]1CCC(F)(F)C[C@@H]1c1ccn[nH]1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H20F3N5O3S/c1-12-8-18(32(29,30)28-19-4-6-24-11-25-19)14(21)9-17(12)31-16-2-5-20(22,23)10-13(16)15-3-7-26-27-15/h3-4,6-9,11,13,16H,2,5,10H2,1H3,(H,26,27)(H,24,25,28)/t13-,16+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258228
PNG
(US9493448, 135)
Show SMILES Cn1nccc1[C@H]1CC(F)(F)C[C@@H]1Oc1cc(F)c(c(F)c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C19H17F4N5O3S/c1-28-15(2-5-26-28)12-8-19(22,23)9-16(12)31-11-6-13(20)18(14(21)7-11)32(29,30)27-17-3-4-24-10-25-17/h2-7,10,12,16H,8-9H2,1H3,(H,24,25,27)/t12-,16+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258177
PNG
(US9493448, 82)
Show SMILES Nc1nnccc1[C@H]1CCCC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H20F2N6O3S/c21-14-10-18(32(29,30)28-19-6-7-24-11-25-19)15(22)9-17(14)31-16-4-2-1-3-12(16)13-5-8-26-27-20(13)23/h5-12,16H,1-4H2,(H2,23,27)(H,24,25,28)/t12-,16+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258226
PNG
(US9493448, 133)
Show SMILES Cc1cc(c(F)cc1O[C@H]1CC(F)(F)C[C@@H]1c1ccnn1C)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H20F3N5O3S/c1-12-7-18(32(29,30)27-19-4-5-24-11-25-19)14(21)8-16(12)31-17-10-20(22,23)9-13(17)15-3-6-26-28(15)2/h3-8,11,13,17H,9-10H2,1-2H3,(H,24,25,27)/t13-,17+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258234
PNG
(US9493448, 141)
Show SMILES Cn1nccc1[C@H]1CCC(F)(F)C[C@@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H19ClF3N5O3S/c1-29-15(3-7-27-29)12-2-5-20(23,24)10-17(12)32-16-9-14(22)18(8-13(16)21)33(30,31)28-19-4-6-25-11-26-19/h3-4,6-9,11-12,17H,2,5,10H2,1H3,(H,25,26,28)/t12-,17+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258112
PNG
(US9493448, 14 | US9493448, 31)
Show SMILES Cn1nccc1[C@H]1CCC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C19H19F2N5O3S/c1-26-15(5-8-24-26)12-3-2-4-16(12)29-17-9-14(21)18(10-13(17)20)30(27,28)25-19-6-7-22-11-23-19/h5-12,16H,2-4H2,1H3,(H,22,23,25)/t12-,16+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258224
PNG
(US9493448, 131)
Show SMILES Cn1nccc1[C@H]1CC(F)(F)CC[C@@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H19ClF3N5O3S/c1-29-15(3-7-27-29)12-10-20(23,24)5-2-16(12)32-17-9-14(22)18(8-13(17)21)33(30,31)28-19-4-6-25-11-26-19/h3-4,6-9,11-12,16H,2,5,10H2,1H3,(H,25,26,28)/t12-,16+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258257
PNG
(US9493448, 166)
Show SMILES CC(=O)O[C@@H]1CC[C@H](Oc2cc(F)c(cc2Cl)S(=O)(=O)Nc2ccncn2)[C@H](C1)c1ccnn1C
Show InChI InChI=1S/C22H23ClFN5O5S/c1-13(30)33-14-3-4-19(15(9-14)18-5-8-27-29(18)2)34-20-11-17(24)21(10-16(20)23)35(31,32)28-22-6-7-25-12-26-22/h5-8,10-12,14-15,19H,3-4,9H2,1-2H3,(H,25,26,28)/t14-,15-,19+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258188
PNG
(US9493448, 93)
Show SMILES Cn1nccc1[C@H]1CC(C)(C)C[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C21H23F2N5O3S/c1-21(2)10-13(16-4-7-26-28(16)3)18(11-21)31-17-8-15(23)19(9-14(17)22)32(29,30)27-20-5-6-24-12-25-20/h4-9,12-13,18H,10-11H2,1-3H3,(H,24,25,27)/t13-,18+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258174
PNG
(US9493448, 79)
Show SMILES Cn1nccc1[C@H]1CCCC[C@@H]1Oc1ccc(c(F)c1Cl)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H21ClFN5O3S/c1-27-14(8-11-25-27)13-4-2-3-5-15(13)30-16-6-7-17(20(22)19(16)21)31(28,29)26-18-9-10-23-12-24-18/h6-13,15H,2-5H2,1H3,(H,23,24,26)/t13-,15+/m1/s1
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n/an/a 70n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258198
PNG
(US9493448, 104)
Show SMILES Fc1cc(O[C@H]2CC(F)(F)CC[C@@H]2c2cn[nH]c2)cc(F)c1S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C19H17F4N5O3S/c20-14-5-12(6-15(21)18(14)32(29,30)28-17-2-4-24-10-25-17)31-16-7-19(22,23)3-1-13(16)11-8-26-27-9-11/h2,4-6,8-10,13,16H,1,3,7H2,(H,26,27)(H,24,25,28)/t13-,16+/m1/s1
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n/an/a 71n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258155
PNG
(US9493448, 57)
Show SMILES Cc1cc(ccc1O[C@H]1CCCCC[C@@H]1c1ccnn1C)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C22H27N5O3S/c1-16-14-17(31(28,29)26-22-11-12-23-15-24-22)8-9-20(16)30-21-7-5-3-4-6-18(21)19-10-13-25-27(19)2/h8-15,18,21H,3-7H2,1-2H3,(H,23,24,26)/t18-,21+/m1/s1
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n/an/a 75n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258208
PNG
(US9493448, 114)
Show SMILES Cn1nccc1[C@H]1CCC[C@@H]1Oc1ccc(c(F)c1)S(=O)(=O)Nc1ccnc(F)n1
Show InChI InChI=1S/C19H19F2N5O3S/c1-26-15(7-10-23-26)13-3-2-4-16(13)29-12-5-6-17(14(20)11-12)30(27,28)25-18-8-9-22-19(21)24-18/h5-11,13,16H,2-4H2,1H3,(H,22,24,25)/t13-,16+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258111
PNG
(US9493448, 13)
Show SMILES Fc1cc(O[C@H]2CCCC[C@@H]2n2ccnc2)c(Cl)cc1S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C18H18ClFN4O3S2/c19-12-7-17(29(25,26)23-18-9-28-11-22-18)13(20)8-16(12)27-15-4-2-1-3-14(15)24-6-5-21-10-24/h5-11,14-15,23H,1-4H2/t14-,15-/m0/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258150
PNG
(US9493448, 52)
Show SMILES Cc1cc(ccc1O[C@H]1CCC[C@@H]1c1ccnn1C)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H23N5O3S/c1-14-12-15(29(26,27)24-20-9-10-21-13-22-20)6-7-18(14)28-19-5-3-4-16(19)17-8-11-23-25(17)2/h6-13,16,19H,3-5H2,1-2H3,(H,21,22,24)/t16-,19+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258166
PNG
(US9493448, 68)
Show SMILES Cc1cc(c(F)cc1O[C@H]1CCCC[C@@H]1c1c[nH]nc1N)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H23FN6O3S/c1-12-8-18(31(28,29)27-19-6-7-23-11-24-19)15(21)9-17(12)30-16-5-3-2-4-13(16)14-10-25-26-20(14)22/h6-11,13,16H,2-5H2,1H3,(H3,22,25,26)(H,23,24,27)/t13-,16+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258175
PNG
(US9493448, 80)
Show SMILES Cn1nccc1[C@H]1CCC[C@@H]1Oc1ccc(c(F)c1Cl)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C19H19ClFN5O3S/c1-26-13(7-10-24-26)12-3-2-4-14(12)29-15-5-6-16(19(21)18(15)20)30(27,28)25-17-8-9-22-11-23-17/h5-12,14H,2-4H2,1H3,(H,22,23,25)/t12-,14+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258167
PNG
(US9493448, 69)
Show SMILES Nc1ncccc1[C@H]1CCCC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C21H21F2N5O3S/c22-15-11-19(32(29,30)28-20-7-9-25-12-27-20)16(23)10-18(15)31-17-6-2-1-4-13(17)14-5-3-8-26-21(14)24/h3,5,7-13,17H,1-2,4,6H2,(H2,24,26)(H,25,27,28)/t13-,17+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258185
PNG
(US9493448, 137 | US9493448, 90)
Show SMILES Cc1cc(c(F)cc1O[C@H]1CC(F)(F)CC[C@@H]1c1ccnn1C)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C21H22F3N5O3S/c1-13-9-19(33(30,31)28-20-5-7-25-12-26-20)15(22)10-17(13)32-18-11-21(23,24)6-3-14(18)16-4-8-27-29(16)2/h4-5,7-10,12,14,18H,3,6,11H2,1-2H3,(H,25,26,28)/t14-,18+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258140
PNG
(US9493448, 42)
Show SMILES Cn1nccc1[C@H]1CCCCC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C21H23F2N5O3S/c1-28-17(7-10-26-28)14-5-3-2-4-6-18(14)31-19-11-16(23)20(12-15(19)22)32(29,30)27-21-8-9-24-13-25-21/h7-14,18H,2-6H2,1H3,(H,24,25,27)/t14-,18+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258123
PNG
(US9493448, 25)
Show SMILES Cn1nccc1[C@H]1CCCC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H21F2N5O3S/c1-27-16(6-9-25-27)13-4-2-3-5-17(13)30-18-10-15(22)19(11-14(18)21)31(28,29)26-20-7-8-23-12-24-20/h6-13,17H,2-5H2,1H3,(H,23,24,26)/t13-,17+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258133
PNG
(US9493448, 35)
Show SMILES Nc1cc(ccn1)[C@H]1CCCC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C21H21F2N5O3S/c22-15-11-19(32(29,30)28-21-6-7-25-12-27-21)16(23)10-18(15)31-17-4-2-1-3-14(17)13-5-8-26-20(24)9-13/h5-12,14,17H,1-4H2,(H2,24,26)(H,25,27,28)/t14-,17+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258136
PNG
(US9493448, 119 | US9493448, 38 | US9493448, 95)
Show SMILES CCn1nccc1[C@H]1CCC[C@@H]1Oc1ccc(c(F)c1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H21F2N5O3S/c1-2-27-14(8-11-25-27)13-4-3-5-15(13)30-16-6-7-17(20(22)19(16)21)31(28,29)26-18-9-10-23-12-24-18/h6-13,15H,2-5H2,1H3,(H,23,24,26)/t13-,15+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258222
PNG
(US9493448, 129)
Show SMILES Cn1nccc1[C@H]1CC(F)(F)CC[C@@H]1Oc1cc(F)c(c(F)c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H19F4N5O3S/c1-29-16(3-7-27-29)13-10-20(23,24)5-2-17(13)32-12-8-14(21)19(15(22)9-12)33(30,31)28-18-4-6-25-11-26-18/h3-4,6-9,11,13,17H,2,5,10H2,1H3,(H,25,26,28)/t13-,17+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258171
PNG
(US9493448, 73)
Show SMILES Cc1c(F)c(ccc1O[C@H]1CCCC[C@@H]1c1c[nH]nc1N)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H23FN6O3S/c1-12-15(30-16-5-3-2-4-13(16)14-10-25-26-20(14)22)6-7-17(19(12)21)31(28,29)27-18-8-9-23-11-24-18/h6-11,13,16H,2-5H2,1H3,(H3,22,25,26)(H,23,24,27)/t13-,16+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258099
PNG
(US9493448, 1 | US9493448, 2 | US9493448, 3 | US949...)
Show SMILES Fc1cc(c(F)cc1O[C@H]1CCCC[C@@H]1c1ccccc1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H19F2N3O3S2/c21-15-11-19(30(26,27)25-20-23-12-24-29-20)16(22)10-18(15)28-17-9-5-4-8-14(17)13-6-2-1-3-7-13/h1-3,6-7,10-12,14,17H,4-5,8-9H2,(H,23,24,25)/t14-,17+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258145
PNG
(US9493448, 102 | US9493448, 47)
Show SMILES Cn1nccc1[C@H]1CCC(F)(F)C[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H19F4N5O3S/c1-29-15(3-7-27-29)12-2-5-20(23,24)10-17(12)32-16-8-14(22)18(9-13(16)21)33(30,31)28-19-4-6-25-11-26-19/h3-4,6-9,11-12,17H,2,5,10H2,1H3,(H,25,26,28)/t12-,17+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258160
PNG
(US9493448, 62)
Show SMILES Cn1nccc1[C@H]1CCC[C@@H]1Oc1cc(F)c(cc1C#N)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H19FN6O3S/c1-27-16(5-8-25-27)14-3-2-4-17(14)30-18-10-15(21)19(9-13(18)11-22)31(28,29)26-20-6-7-23-12-24-20/h5-10,12,14,17H,2-4H2,1H3,(H,23,24,26)/t14-,17+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258110
PNG
(US9493448, 12)
Show SMILES CCn1nccc1[C@H]1CCCC[C@@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C20H22ClFN4O3S2/c1-2-26-16(7-8-24-26)13-5-3-4-6-17(13)29-18-10-15(22)19(9-14(18)21)31(27,28)25-20-11-30-12-23-20/h7-13,17,25H,2-6H2,1H3/t13-,17+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258220
PNG
(US9493448, 127 | US9493448, 143)
Show SMILES Cc1cc(c(F)cc1O[C@H]1CC(F)(F)CC[C@@H]1c1cn[nH]c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H20F3N5O3S/c1-12-6-18(32(29,30)28-19-3-5-24-11-25-19)15(21)7-16(12)31-17-8-20(22,23)4-2-14(17)13-9-26-27-10-13/h3,5-7,9-11,14,17H,2,4,8H2,1H3,(H,26,27)(H,24,25,28)/t14-,17+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258189
PNG
(US9493448, 171 | US9493448, 94)
Show SMILES Fc1cc(O[C@H]2CCCC[C@@H]2c2cn[nH]c2)cc(F)c1S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C19H19F2N5O3S/c20-15-7-13(29-17-4-2-1-3-14(17)12-9-24-25-10-12)8-16(21)19(15)30(27,28)26-18-5-6-22-11-23-18/h5-11,14,17H,1-4H2,(H,24,25)(H,22,23,26)/t14-,17+/m1/s1
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n/an/a 120n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258184
PNG
(US9493448, 89)
Show SMILES CCc1cc(ccc1O[C@H]1CCCC[C@@H]1c1c[nH]nc1N)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C21H26N6O3S/c1-2-14-11-15(31(28,29)27-20-9-10-23-13-24-20)7-8-18(14)30-19-6-4-3-5-16(19)17-12-25-26-21(17)22/h7-13,16,19H,2-6H2,1H3,(H3,22,25,26)(H,23,24,27)/t16-,19+/m1/s1
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n/an/a 130n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258121
PNG
(US9493448, 23)
Show SMILES Cn1nccc1[C@H]1CCC[C@@H]1Oc1ccc(cc1Cl)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C19H20ClN5O3S/c1-25-16(7-10-23-25)14-3-2-4-17(14)28-18-6-5-13(11-15(18)20)29(26,27)24-19-8-9-21-12-22-19/h5-12,14,17H,2-4H2,1H3,(H,21,22,24)/t14-,17+/m1/s1
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n/an/a 130n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258252
PNG
(US9493448, 161 | US9493448, 165)
Show SMILES Cn1nccc1[C@H]1C[C@H](O)CC[C@@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H21ClFN5O4S/c1-27-16(4-7-25-27)13-8-12(28)2-3-17(13)31-18-10-15(22)19(9-14(18)21)32(29,30)26-20-5-6-23-11-24-20/h4-7,9-13,17,28H,2-3,8H2,1H3,(H,23,24,26)/t12-,13-,17+/m1/s1
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n/an/a 130n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258163
PNG
(US9493448, 65)
Show SMILES Cc1c(O[C@H]2CCC[C@@H]2c2ccnn2C)ccc(c1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H22FN5O3S/c1-13-16(29-17-5-3-4-14(17)15-8-11-24-26(15)2)6-7-18(20(13)21)30(27,28)25-19-9-10-22-12-23-19/h6-12,14,17H,3-5H2,1-2H3,(H,22,23,25)/t14-,17+/m1/s1
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n/an/a 130n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258176
PNG
(US9493448, 172 | US9493448, 81)
Show SMILES Cc1cc(c(F)cc1O[C@H]1CCCC[C@@H]1c1cn[nH]c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H22FN5O3S/c1-13-8-19(30(27,28)26-20-6-7-22-12-23-20)16(21)9-18(13)29-17-5-3-2-4-15(17)14-10-24-25-11-14/h6-12,15,17H,2-5H2,1H3,(H,24,25)(H,22,23,26)/t15-,17+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258112
PNG
(US9493448, 14 | US9493448, 31)
Show SMILES Cn1nccc1[C@H]1CCC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C19H19F2N5O3S/c1-26-15(5-8-24-26)12-3-2-4-16(12)29-17-9-14(21)18(10-13(17)20)30(27,28)25-19-6-7-22-11-23-19/h5-12,16H,2-4H2,1H3,(H,22,23,25)/t12-,16+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258169
PNG
(US9493448, 71)
Show SMILES Nc1n[nH]cc1[C@H]1CCCC[C@@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C19H20ClFN6O3S/c20-13-7-17(31(28,29)27-18-5-6-23-10-24-18)14(21)8-16(13)30-15-4-2-1-3-11(15)12-9-25-26-19(12)22/h5-11,15H,1-4H2,(H3,22,25,26)(H,23,24,27)/t11-,15+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258139
PNG
(US9493448, 41)
Show SMILES CCn1nccc1[C@H]1CCCC[C@@H]1Oc1ccc(c(F)c1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C21H23F2N5O3S/c1-2-28-15(9-12-26-28)14-5-3-4-6-16(14)31-17-7-8-18(21(23)20(17)22)32(29,30)27-19-10-11-24-13-25-19/h7-14,16H,2-6H2,1H3,(H,24,25,27)/t14-,16+/m1/s1
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n/an/a 160n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258186
PNG
(US9493448, 91)
Show SMILES Nc1n[nH]cc1[C@H]1CCCC[C@@H]1Oc1ccc(c(F)c1Cl)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C19H20ClFN6O3S/c20-17-14(30-13-4-2-1-3-11(13)12-9-25-26-19(12)22)5-6-15(18(17)21)31(28,29)27-16-7-8-23-10-24-16/h5-11,13H,1-4H2,(H3,22,25,26)(H,23,24,27)/t11-,13+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258116
PNG
(US9493448, 18)
Show SMILES Cn1nccc1[C@H]1CCC[C@@H]1Oc1ccc(cc1F)S(=O)(=O)Nc1ccnc(F)n1
Show InChI InChI=1S/C19H19F2N5O3S/c1-26-15(7-10-23-26)13-3-2-4-16(13)29-17-6-5-12(11-14(17)20)30(27,28)25-18-8-9-22-19(21)24-18/h5-11,13,16H,2-4H2,1H3,(H,22,24,25)/t13-,16+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258210
PNG
(US9493448, 116)
Show SMILES Nc1n[nH]cc1[C@H]1CCCC[C@@H]1Oc1cc(F)c(c(F)c1)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C18H19F2N5O3S2/c19-13-5-10(6-14(20)17(13)30(26,27)25-16-8-29-9-22-16)28-15-4-2-1-3-11(15)12-7-23-24-18(12)21/h5-9,11,15,25H,1-4H2,(H3,21,23,24)/t11-,15+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258180
PNG
(US9493448, 85)
Show SMILES Cc1cc(c(F)cc1O[C@H]1CCC[C@@H]1c1c[nH]nc1N)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C19H21FN6O3S/c1-11-7-17(30(27,28)26-18-5-6-22-10-23-18)14(20)8-16(11)29-15-4-2-3-12(15)13-9-24-25-19(13)21/h5-10,12,15H,2-4H2,1H3,(H3,21,24,25)(H,22,23,26)/t12-,15+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258136
PNG
(US9493448, 119 | US9493448, 38 | US9493448, 95)
Show SMILES CCn1nccc1[C@H]1CCC[C@@H]1Oc1ccc(c(F)c1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H21F2N5O3S/c1-2-27-14(8-11-25-27)13-4-3-5-15(13)30-16-6-7-17(20(22)19(16)21)31(28,29)26-18-9-10-23-12-24-18/h6-13,15H,2-5H2,1H3,(H,23,24,26)/t13-,15+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258195
PNG
(US9493448, 101)
Show SMILES Cc1cc(c(F)cc1O[C@H]1CCC[C@@H]1c1cn[nH]c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C19H20FN5O3S/c1-12-7-18(29(26,27)25-19-5-6-21-11-22-19)15(20)8-17(12)28-16-4-2-3-14(16)13-9-23-24-10-13/h5-11,14,16H,2-4H2,1H3,(H,23,24)(H,21,22,25)/t14-,16+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258143
PNG
(US9493448, 45)
Show SMILES CCn1nccc1[C@H]1CCCC[C@@H]1Oc1ccc(c(F)c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C21H24FN5O3S/c1-2-27-18(9-12-25-27)16-5-3-4-6-19(16)30-15-7-8-20(17(22)13-15)31(28,29)26-21-10-11-23-14-24-21/h7-14,16,19H,2-6H2,1H3,(H,23,24,26)/t16-,19+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258254
PNG
(US9493448, 163)
Show SMILES Cn1nccc1[C@H]1CC[C@H](O)C[C@@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H21ClFN5O4S/c1-27-16(4-7-25-27)13-3-2-12(28)8-17(13)31-18-10-15(22)19(9-14(18)21)32(29,30)26-20-5-6-23-11-24-20/h4-7,9-13,17,28H,2-3,8H2,1H3,(H,23,24,26)/t12-,13+,17-/m0/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258218
PNG
(US9493448, 125)
Show SMILES Cc1cc(c(F)cc1O[C@H]1CC(F)(F)CC[C@@H]1c1ccnn1C)S(=O)(=O)Nc1nncs1
Show InChI InChI=1S/C19H20F3N5O3S2/c1-11-7-17(32(28,29)26-18-25-23-10-31-18)13(20)8-15(11)30-16-9-19(21,22)5-3-12(16)14-4-6-24-27(14)2/h4,6-8,10,12,16H,3,5,9H2,1-2H3,(H,25,26)/t12-,16+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258124
PNG
(US9493448, 26)
Show SMILES Cn1nccc1[C@H]1CCC[C@@H]1Oc1ccc(cc1C#N)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H20N6O3S/c1-26-17(7-10-24-26)16-3-2-4-19(16)29-18-6-5-15(11-14(18)12-21)30(27,28)25-20-8-9-22-13-23-20/h5-11,13,16,19H,2-4H2,1H3,(H,22,23,25)/t16-,19+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258225
PNG
(US9493448, 132)
Show SMILES Cn1nccc1[C@H]1CC(F)(F)C[C@@H]1Oc1ccc(c(F)c1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C19H17F4N5O3S/c1-28-12(4-7-26-28)11-8-19(22,23)9-14(11)31-13-2-3-15(18(21)17(13)20)32(29,30)27-16-5-6-24-10-25-16/h2-7,10-11,14H,8-9H2,1H3,(H,24,25,27)/t11-,14+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258135
PNG
(US9493448, 37)
Show SMILES CCn1nccc1[C@H]1CCC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H21F2N5O3S/c1-2-27-16(6-9-25-27)13-4-3-5-17(13)30-18-10-15(22)19(11-14(18)21)31(28,29)26-20-7-8-23-12-24-20/h6-13,17H,2-5H2,1H3,(H,23,24,26)/t13-,17+/m1/s1
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n/an/a 210n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258199
PNG
(US9493448, 105)
Show SMILES Cn1nccc1[C@H]1CCC(F)(F)C[C@@H]1Oc1ccc(c(F)c1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H19F4N5O3S/c1-29-13(5-9-27-29)12-4-7-20(23,24)10-15(12)32-14-2-3-16(19(22)18(14)21)33(30,31)28-17-6-8-25-11-26-17/h2-3,5-6,8-9,11-12,15H,4,7,10H2,1H3,(H,25,26,28)/t12-,15+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258114
PNG
(US9493448, 16)
Show SMILES Cn1nccc1[C@H]1CCC[C@@H]1Oc1ccc(cc1F)S(=O)(=O)Nc1nccs1
Show InChI InChI=1S/C18H19FN4O3S2/c1-23-15(7-8-21-23)13-3-2-4-16(13)26-17-6-5-12(11-14(17)19)28(24,25)22-18-20-9-10-27-18/h5-11,13,16H,2-4H2,1H3,(H,20,22)/t13-,16+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258136
PNG
(US9493448, 119 | US9493448, 38 | US9493448, 95)
Show SMILES CCn1nccc1[C@H]1CCC[C@@H]1Oc1ccc(c(F)c1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H21F2N5O3S/c1-2-27-14(8-11-25-27)13-4-3-5-15(13)30-16-6-7-17(20(22)19(16)21)31(28,29)26-18-9-10-23-12-24-18/h6-13,15H,2-5H2,1H3,(H,23,24,26)/t13-,15+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258154
PNG
(US9493448, 56)
Show SMILES Cn1nccc1[C@H]1CCCC[C@@H]1Oc1ccc(cc1C#N)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C21H22N6O3S/c1-27-18(8-11-25-27)17-4-2-3-5-20(17)30-19-7-6-16(12-15(19)13-22)31(28,29)26-21-9-10-23-14-24-21/h6-12,14,17,20H,2-5H2,1H3,(H,23,24,26)/t17-,20+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258132
PNG
(US9493448, 34)
Show SMILES Nc1n[nH]cc1[C@H]1CCCC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C19H20F2N6O3S/c20-13-8-17(31(28,29)27-18-5-6-23-10-24-18)14(21)7-16(13)30-15-4-2-1-3-11(15)12-9-25-26-19(12)22/h5-11,15H,1-4H2,(H3,22,25,26)(H,23,24,27)/t11-,15+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258190
PNG
(US9493448, 96)
Show SMILES CC(=O)Nc1n[nH]cc1[C@H]1CCCC[C@@H]1Oc1cc(F)c(cc1C)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C22H25FN6O4S/c1-13-9-20(34(31,32)29-21-7-8-24-12-25-21)17(23)10-19(13)33-18-6-4-3-5-15(18)16-11-26-28-22(16)27-14(2)30/h7-12,15,18H,3-6H2,1-2H3,(H,24,25,29)(H2,26,27,28,30)/t15-,18+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258119
PNG
(US9493448, 21)
Show SMILES Cn1nccc1[C@H]1CCC[C@@H]1Oc1ccc(cc1C(F)(F)F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H20F3N5O3S/c1-28-16(7-10-26-28)14-3-2-4-17(14)31-18-6-5-13(11-15(18)20(21,22)23)32(29,30)27-19-8-9-24-12-25-19/h5-12,14,17H,2-4H2,1H3,(H,24,25,27)/t14-,17+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258099
PNG
(US9493448, 1 | US9493448, 2 | US9493448, 3 | US949...)
Show SMILES Fc1cc(c(F)cc1O[C@H]1CCCC[C@@H]1c1ccccc1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H19F2N3O3S2/c21-15-11-19(30(26,27)25-20-23-12-24-29-20)16(22)10-18(15)28-17-9-5-4-8-14(17)13-6-2-1-3-7-13/h1-3,6-7,10-12,14,17H,4-5,8-9H2,(H,23,24,25)/t14-,17+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258214
PNG
(US9493448, 120)
Show SMILES CO[C@@H]1C[C@H](Oc2cc(F)c(cc2F)S(=O)(=O)Nc2ccncn2)[C@H](C1)c1ccnn1C
Show InChI InChI=1S/C20H21F2N5O4S/c1-27-16(3-6-25-27)13-7-12(30-2)8-17(13)31-18-9-15(22)19(10-14(18)21)32(28,29)26-20-4-5-23-11-24-20/h3-6,9-13,17H,7-8H2,1-2H3,(H,23,24,26)/t12-,13+,17-/m0/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258200
PNG
(US9493448, 106)
Show SMILES Cn1nccc1[C@H]1C[C@@H](F)C[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C19H18F3N5O3S/c1-27-15(2-5-25-27)12-6-11(20)7-16(12)30-17-8-14(22)18(9-13(17)21)31(28,29)26-19-3-4-23-10-24-19/h2-5,8-12,16H,6-7H2,1H3,(H,23,24,26)/t11-,12-,16+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258182
PNG
(US9493448, 87)
Show SMILES Cn1nccc1C1CCC[C@@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1nncs1
Show InChI InChI=1S/C17H17ClFN5O3S2/c1-24-13(5-6-21-24)10-3-2-4-14(10)27-15-8-12(19)16(7-11(15)18)29(25,26)23-17-22-20-9-28-17/h5-10,14H,2-4H2,1H3,(H,22,23)/t10?,14-/m0/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258229
PNG
(US9493448, 136)
Show SMILES Cn1nccc1[C@H]1CC(F)(F)C[C@@H]1Oc1ccc(c(F)c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C19H18F3N5O3S/c1-27-15(4-7-25-27)13-9-19(21,22)10-16(13)30-12-2-3-17(14(20)8-12)31(28,29)26-18-5-6-23-11-24-18/h2-8,11,13,16H,9-10H2,1H3,(H,23,24,26)/t13-,16+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258103
PNG
(US9493448, 10 | US9493448, 5)
Show SMILES Cn1nccc1[C@H]1CCCC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1cscn1
Show InChI InChI=1S/C19H20F2N4O3S2/c1-25-15(6-7-23-25)12-4-2-3-5-16(12)28-17-8-14(21)18(9-13(17)20)30(26,27)24-19-10-29-11-22-19/h6-12,16,24H,2-5H2,1H3/t12-,16+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258131
PNG
(US9493448, 33)
Show SMILES Fc1cc(c(F)cc1O[C@H]1CCCC[C@@H]1c1cn[nH]c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C19H19F2N5O3S/c20-14-8-18(30(27,28)26-19-5-6-22-11-23-19)15(21)7-17(14)29-16-4-2-1-3-13(16)12-9-24-25-10-12/h5-11,13,16H,1-4H2,(H,24,25)(H,22,23,26)/t13-,16+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258204
PNG
(US9493448, 110)
Show SMILES Cn1nccc1[C@H]1CCC(F)(F)C[C@@H]1Oc1ccc(c(F)c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H20F3N5O3S/c1-28-16(5-9-26-28)14-4-7-20(22,23)11-17(14)31-13-2-3-18(15(21)10-13)32(29,30)27-19-6-8-24-12-25-19/h2-3,5-6,8-10,12,14,17H,4,7,11H2,1H3,(H,24,25,27)/t14-,17+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258206
PNG
(US9493448, 112)
Show SMILES Cn1nccc1[C@H]1C[C@@H](CC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1)OCc1ccccc1
Show InChI InChI=1S/C27H27F2N5O4S/c1-34-23(9-12-32-34)20-13-19(37-16-18-5-3-2-4-6-18)7-8-24(20)38-25-14-22(29)26(15-21(25)28)39(35,36)33-27-10-11-30-17-31-27/h2-6,9-12,14-15,17,19-20,24H,7-8,13,16H2,1H3,(H,30,31,33)/t19-,20-,24+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258183
PNG
(US9493448, 88)
Show SMILES Cn1nccc1[C@H]1CC(F)(F)CC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H19F4N5O3S/c1-29-15(3-7-27-29)12-10-20(23,24)5-2-16(12)32-17-8-14(22)18(9-13(17)21)33(30,31)28-19-4-6-25-11-26-19/h3-4,6-9,11-12,16H,2,5,10H2,1H3,(H,25,26,28)/t12-,16+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258197
PNG
(US9493448, 103)
Show SMILES Fc1cc(c(F)cc1O[C@H]1CC(F)(F)CC[C@@H]1c1cn[nH]c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C19H17F4N5O3S/c20-13-6-17(32(29,30)28-18-2-4-24-10-25-18)14(21)5-15(13)31-16-7-19(22,23)3-1-12(16)11-8-26-27-9-11/h2,4-6,8-10,12,16H,1,3,7H2,(H,26,27)(H,24,25,28)/t12-,16+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258142
PNG
(US9493448, 44)
Show SMILES Cn1nccc1[C@H]1CCCC[C@@H]1Oc1ccc(c(F)c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H22FN5O3S/c1-26-17(8-11-24-26)15-4-2-3-5-18(15)29-14-6-7-19(16(21)12-14)30(27,28)25-20-9-10-22-13-23-20/h6-13,15,18H,2-5H2,1H3,(H,22,23,25)/t15-,18+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258168
PNG
(US9493448, 70)
Show SMILES Cc1ncccc1[C@H]1CCCC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C22H22F2N4O3S/c1-14-15(6-4-9-26-14)16-5-2-3-7-19(16)31-20-11-18(24)21(12-17(20)23)32(29,30)28-22-8-10-25-13-27-22/h4,6,8-13,16,19H,2-3,5,7H2,1H3,(H,25,27,28)/t16-,19+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258138
PNG
(US9493448, 40)
Show SMILES Cn1nccc1[C@H]1CCCC[C@@H]1Oc1ccc(c(F)c1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H21F2N5O3S/c1-27-14(8-11-25-27)13-4-2-3-5-15(13)30-16-6-7-17(20(22)19(16)21)31(28,29)26-18-9-10-23-12-24-18/h6-13,15H,2-5H2,1H3,(H,23,24,26)/t13-,15+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258151
PNG
(US9493448, 53)
Show SMILES Fc1cc(c(F)cc1O[C@H]1CCCC[C@@H]1c1ccnnc1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H19F2N5O3S/c21-15-10-19(31(28,29)27-20-6-7-23-12-24-20)16(22)9-18(15)30-17-4-2-1-3-14(17)13-5-8-25-26-11-13/h5-12,14,17H,1-4H2,(H,23,24,27)/t14-,17+/m1/s1
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n/an/a 330n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258194
PNG
(US9493448, 100)
Show SMILES Cn1nccc1[C@H]1[C@@H](CCC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1)OCc1ccccc1
Show InChI InChI=1S/C27H27F2N5O4S/c1-34-21(10-13-32-34)27-22(37-16-18-6-3-2-4-7-18)8-5-9-23(27)38-24-14-20(29)25(15-19(24)28)39(35,36)33-26-11-12-30-17-31-26/h2-4,6-7,10-15,17,22-23,27H,5,8-9,16H2,1H3,(H,30,31,33)/t22-,23+,27+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258193
PNG
(US9493448, 99)
Show SMILES Cn1nccc1[C@@H]1[C@H](CCC1(C)C)Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C21H23F2N5O3S/c1-21(2)7-4-16(20(21)15-5-9-26-28(15)3)31-17-10-14(23)18(11-13(17)22)32(29,30)27-19-6-8-24-12-25-19/h5-6,8-12,16,20H,4,7H2,1-3H3,(H,24,25,27)/t16-,20+/m0/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258105
PNG
(US9493448, 7)
Show SMILES Fc1cc(c(F)cc1O[C@H]1CCCCC[C@@H]1c1ccccc1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C21H21F2N3O3S2/c22-16-12-20(31(27,28)26-21-24-13-25-30-21)17(23)11-19(16)29-18-10-6-2-5-9-15(18)14-7-3-1-4-8-14/h1,3-4,7-8,11-13,15,18H,2,5-6,9-10H2,(H,24,25,26)/t15-,18+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258134
PNG
(US9493448, 36)
Show SMILES Nc1cc(ccn1)[C@H]1CCC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H19F2N5O3S/c21-14-10-18(31(28,29)27-20-5-6-24-11-26-20)15(22)9-17(14)30-16-3-1-2-13(16)12-4-7-25-19(23)8-12/h4-11,13,16H,1-3H2,(H2,23,25)(H,24,26,27)/t13-,16+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258128
PNG
(US9493448, 30)
Show SMILES Cn1nccc1[C@H]1CCC[C@@H]1Oc1ccc(c(F)c1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C19H19F2N5O3S/c1-26-13(7-10-24-26)12-3-2-4-14(12)29-15-5-6-16(19(21)18(15)20)30(27,28)25-17-8-9-22-11-23-17/h5-12,14H,2-4H2,1H3,(H,22,23,25)/t12-,14+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258117
PNG
(US9493448, 19)
Show SMILES Cn1nccc1[C@H]1CCC[C@@H]1Oc1cc(Cl)c(cc1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C19H19ClFN5O3S/c1-26-15(5-8-24-26)12-3-2-4-16(12)29-17-9-13(20)18(10-14(17)21)30(27,28)25-19-6-7-22-11-23-19/h5-12,16H,2-4H2,1H3,(H,22,23,25)/t12-,16+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258115
PNG
(US9493448, 17)
Show SMILES Cn1nccc1[C@H]1CCC[C@@H]1Oc1ccc(cc1F)S(=O)(=O)Nc1cc(F)ncn1
Show InChI InChI=1S/C19H19F2N5O3S/c1-26-15(7-8-24-26)13-3-2-4-16(13)29-17-6-5-12(9-14(17)20)30(27,28)25-19-10-18(21)22-11-23-19/h5-11,13,16H,2-4H2,1H3,(H,22,23,25)/t13-,16+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258120
PNG
(US9493448, 22)
Show SMILES Fc1cc(c(F)cc1O[C@H]1CCCC[C@@H]1c1ccn[nH]1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C19H19F2N5O3S/c20-13-10-18(30(27,28)26-19-6-7-22-11-23-19)14(21)9-17(13)29-16-4-2-1-3-12(16)15-5-8-24-25-15/h5-12,16H,1-4H2,(H,24,25)(H,22,23,26)/t12-,16+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258251
PNG
(US9493448, 160)
Show SMILES Cn1nccc1[C@H]1CC[C@@H](O)C[C@@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H21ClFN5O4S/c1-27-16(4-7-25-27)13-3-2-12(28)8-17(13)31-18-10-15(22)19(9-14(18)21)32(29,30)26-20-5-6-23-11-24-20/h4-7,9-13,17,28H,2-3,8H2,1H3,(H,23,24,26)/t12-,13-,17+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258209
PNG
(US9493448, 115)
Show SMILES CCn1nccc1[C@H]1CCC[C@@H]1Oc1ccc(c(F)c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H22FN5O3S/c1-2-26-17(8-11-24-26)15-4-3-5-18(15)29-14-6-7-19(16(21)12-14)30(27,28)25-20-9-10-22-13-23-20/h6-13,15,18H,2-5H2,1H3,(H,22,23,25)/t15-,18+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258239
PNG
(US9493448, 147)
Show SMILES Fc1cc(O[C@H]2CC(F)(F)CC[C@@H]2c2cn[nH]c2)ccc1S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C19H18F3N5O3S/c20-15-7-13(1-2-17(15)31(28,29)27-18-4-6-23-11-24-18)30-16-8-19(21,22)5-3-14(16)12-9-25-26-10-12/h1-2,4,6-7,9-11,14,16H,3,5,8H2,(H,25,26)(H,23,24,27)/t14-,16+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258104
PNG
(US9493448, 6)
Show SMILES Fc1cc(c(F)cc1O[C@H]1CCC[C@@H]1c1ccccc1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C19H17F2N3O3S2/c20-14-10-18(29(25,26)24-19-22-11-23-28-19)15(21)9-17(14)27-16-8-4-7-13(16)12-5-2-1-3-6-12/h1-3,5-6,9-11,13,16H,4,7-8H2,(H,22,23,24)/t13-,16+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258178
PNG
(US9493448, 83)
Show SMILES Fc1c(O[C@H]2CCCC[C@@H]2c2cn[nH]c2)ccc(c1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C19H19F2N5O3S/c20-18-15(29-14-4-2-1-3-13(14)12-9-24-25-10-12)5-6-16(19(18)21)30(27,28)26-17-7-8-22-11-23-17/h5-11,13-14H,1-4H2,(H,24,25)(H,22,23,26)/t13-,14+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258147
PNG
(US9493448, 49)
Show SMILES Cn1cncc1[C@H]1CCCC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H21F2N5O3S/c1-27-12-24-10-16(27)13-4-2-3-5-17(13)30-18-8-15(22)19(9-14(18)21)31(28,29)26-20-6-7-23-11-25-20/h6-13,17H,2-5H2,1H3,(H,23,25,26)/t13-,17+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258156
PNG
(US9493448, 58)
Show SMILES Cn1nccc1[C@H]1CCCCC[C@@H]1Oc1ccc(c(F)c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C21H24FN5O3S/c1-27-18(9-12-25-27)16-5-3-2-4-6-19(16)30-15-7-8-20(17(22)13-15)31(28,29)26-21-10-11-23-14-24-21/h7-14,16,19H,2-6H2,1H3,(H,23,24,26)/t16-,19+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258149
PNG
(US9493448, 51)
Show SMILES Cn1nccc1[C@H]1CCCCC[C@@H]1Oc1ccc(c(F)c1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C21H23F2N5O3S/c1-28-15(9-12-26-28)14-5-3-2-4-6-16(14)31-17-7-8-18(21(23)20(17)22)32(29,30)27-19-10-11-24-13-25-19/h7-14,16H,2-6H2,1H3,(H,24,25,27)/t14-,16+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258211
PNG
(US9493448, 117)
Show SMILES Cn1nccc1[C@@H]1[C@H](CCCC1(F)F)Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H19F4N5O3S/c1-29-14(4-8-27-29)19-15(3-2-6-20(19,23)24)32-16-9-13(22)17(10-12(16)21)33(30,31)28-18-5-7-25-11-26-18/h4-5,7-11,15,19H,2-3,6H2,1H3,(H,25,26,28)/t15-,19+/m0/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258253
PNG
(US9493448, 162)
Show SMILES Cn1nccc1[C@H]1C[C@@H](O)CC[C@@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H21ClFN5O4S/c1-27-16(4-7-25-27)13-8-12(28)2-3-17(13)31-18-10-15(22)19(9-14(18)21)32(29,30)26-20-5-6-23-11-24-20/h4-7,9-13,17,28H,2-3,8H2,1H3,(H,23,24,26)/t12-,13+,17-/m0/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258223
PNG
(US9493448, 130)
Show SMILES Cn1nccc1[C@H]1CC(F)(F)CC[C@@H]1Oc1ccc(c(F)c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H20F3N5O3S/c1-28-16(5-9-26-28)14-11-20(22,23)7-4-17(14)31-13-2-3-18(15(21)10-13)32(29,30)27-19-6-8-24-12-25-19/h2-3,5-6,8-10,12,14,17H,4,7,11H2,1H3,(H,24,25,27)/t14-,17+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258215
PNG
(US9493448, 121)
Show SMILES CO[C@H]1C[C@H](Oc2cc(F)c(cc2F)S(=O)(=O)Nc2ccncn2)[C@H](C1)c1ccnn1C
Show InChI InChI=1S/C20H21F2N5O4S/c1-27-16(3-6-25-27)13-7-12(30-2)8-17(13)31-18-9-15(22)19(10-14(18)21)32(28,29)26-20-4-5-23-11-24-20/h3-6,9-13,17H,7-8H2,1-2H3,(H,23,24,26)/t12-,13-,17+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258137
PNG
(US9493448, 39)
Show SMILES Fc1cc(c(F)cc1O[C@H]1CCCC[C@@H]1c1cccnc1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C21H20F2N4O3S/c22-16-11-20(31(28,29)27-21-7-9-25-13-26-21)17(23)10-19(16)30-18-6-2-1-5-15(18)14-4-3-8-24-12-14/h3-4,7-13,15,18H,1-2,5-6H2,(H,25,26,27)/t15-,18+/m1/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258187
PNG
(US9493448, 92)
Show SMILES Cn1nncc1[C@H]1CCCC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C19H20F2N6O3S/c1-27-15(10-24-26-27)12-4-2-3-5-16(12)30-17-8-14(21)18(9-13(17)20)31(28,29)25-19-6-7-22-11-23-19/h6-12,16H,2-5H2,1H3,(H,22,23,25)/t12-,16+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258130
PNG
(US9493448, 32)
Show SMILES Fc1cc(c(F)cc1O[C@H]1CCCC[C@@H]1n1ccnc1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C19H19F2N5O3S/c20-13-10-18(30(27,28)25-19-5-6-22-11-24-19)14(21)9-17(13)29-16-4-2-1-3-15(16)26-8-7-23-12-26/h5-12,15-16H,1-4H2,(H,22,24,25)/t15-,16-/m0/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258207
PNG
(US9493448, 113)
Show SMILES Cn1nccc1[C@H]1CC[C@@H](C[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1)OCc1ccccc1
Show InChI InChI=1S/C27H27F2N5O4S/c1-34-23(9-12-32-34)20-8-7-19(37-16-18-5-3-2-4-6-18)13-24(20)38-25-14-22(29)26(15-21(25)28)39(35,36)33-27-10-11-30-17-31-27/h2-6,9-12,14-15,17,19-20,24H,7-8,13,16H2,1H3,(H,30,31,33)/t19-,20+,24-/m0/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258202
PNG
(US9493448, 108)
Show SMILES Fc1cc(O[C@H]2CCCC[C@@H]2c2cn[nH]c2)ccc1S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C19H20FN5O3S/c20-16-9-14(28-17-4-2-1-3-15(17)13-10-23-24-11-13)5-6-18(16)29(26,27)25-19-7-8-21-12-22-19/h5-12,15,17H,1-4H2,(H,23,24)(H,21,22,25)/t15-,17+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258127
PNG
(US9493448, 124 | US9493448, 29)
Show SMILES Cn1nccc1[C@H]1CCC[C@@H]1Oc1ccc(c(F)c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C19H20FN5O3S/c1-25-16(7-10-23-25)14-3-2-4-17(14)28-13-5-6-18(15(20)11-13)29(26,27)24-19-8-9-21-12-22-19/h5-12,14,17H,2-4H2,1H3,(H,21,22,24)/t14-,17+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258127
PNG
(US9493448, 124 | US9493448, 29)
Show SMILES Cn1nccc1[C@H]1CCC[C@@H]1Oc1ccc(c(F)c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C19H20FN5O3S/c1-25-16(7-10-23-25)14-3-2-4-17(14)28-13-5-6-18(15(20)11-13)29(26,27)24-19-8-9-21-12-22-19/h5-12,14,17H,2-4H2,1H3,(H,21,22,24)/t14-,17+/m1/s1
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n/an/a 2.40E+3n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258237
PNG
(US9493448, 144)
Show SMILES Cc1cc(c(F)cc1O[C@@H]1CC(F)(F)CC[C@H]1c1cn[nH]c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H20F3N5O3S/c1-12-6-18(32(29,30)28-19-3-5-24-11-25-19)15(21)7-16(12)31-17-8-20(22,23)4-2-14(17)13-9-26-27-10-13/h3,5-7,9-11,14,17H,2,4,8H2,1H3,(H,26,27)(H,24,25,28)/t14-,17+/m0/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258258
PNG
(US9493448, 167)
Show SMILES Cn1nccc1[C@@H]1CCCC[C@@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H21ClFN5O3S/c1-27-16(6-9-25-27)13-4-2-3-5-17(13)30-18-11-15(22)19(10-14(18)21)31(28,29)26-20-7-8-23-12-24-20/h6-13,17H,2-5H2,1H3,(H,23,24,26)/t13-,17-/m0/s1
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n/an/a 4.60E+3n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258250
PNG
(US9493448, 159)
Show SMILES Fc1cc(O[C@@H]2CCCC[C@H]2c2ccn[nH]2)c(Cl)cc1S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C19H19ClFN5O3S/c20-13-9-18(30(27,28)26-19-6-7-22-11-23-19)14(21)10-17(13)29-16-4-2-1-3-12(16)15-5-8-24-25-15/h5-12,16H,1-4H2,(H,24,25)(H,22,23,26)/t12-,16+/m0/s1
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n/an/a 9.80E+3n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258099
PNG
(US9493448, 1 | US9493448, 2 | US9493448, 3 | US949...)
Show SMILES Fc1cc(c(F)cc1O[C@H]1CCCC[C@@H]1c1ccccc1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H19F2N3O3S2/c21-15-11-19(30(26,27)25-20-23-12-24-29-20)16(22)10-18(15)28-17-9-5-4-8-14(17)13-6-2-1-3-7-13/h1-3,6-7,10-12,14,17H,4-5,8-9H2,(H,23,24,25)/t14-,17+/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258260
PNG
(US9493448, 169)
Show SMILES Fc1cc(O[C@@H]2CCCC[C@H]2c2cn[nH]c2)cc(F)c1S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C19H19F2N5O3S/c20-15-7-13(29-17-4-2-1-3-14(17)12-9-24-25-10-12)8-16(21)19(15)30(27,28)26-18-5-6-22-11-23-18/h5-11,14,17H,1-4H2,(H,24,25)(H,22,23,26)/t14-,17+/m0/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM65040
PNG
(US9493448, 75)
Show SMILES Fc1cc(c(F)cc1O[C@@H]1CCCC[C@H]1c1ccccc1)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H19F2N3O3S2/c21-15-11-19(30(26,27)25-20-23-12-24-29-20)16(22)10-18(15)28-17-9-5-4-8-14(17)13-6-2-1-3-7-13/h1-3,6-7,10-12,14,17H,4-5,8-9H2,(H,23,24,25)/t14-,17+/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258255
PNG
(US9493448, 164)
Show SMILES Cn1nccc1[C@@H]1C[C@@H](O)CC[C@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H21ClFN5O4S/c1-27-16(4-7-25-27)13-8-12(28)2-3-17(13)31-18-10-15(22)19(9-14(18)21)32(29,30)26-20-5-6-23-11-24-20/h4-7,9-13,17,28H,2-3,8H2,1H3,(H,23,24,26)/t12-,13-,17+/m0/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258259
PNG
(US9493448, 168)
Show SMILES Cn1nccc1[C@H]1CCCC[C@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H21ClFN5O3S/c1-27-16(6-9-25-27)13-4-2-3-5-17(13)30-18-11-15(22)19(10-14(18)21)31(28,29)26-20-7-8-23-12-24-20/h6-13,17H,2-5H2,1H3,(H,23,24,26)/t13-,17-/m1/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258261
PNG
(US9493448, 170)
Show SMILES Cc1cc(c(F)cc1O[C@@H]1CCCC[C@H]1c1cn[nH]c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H22FN5O3S/c1-13-8-19(30(27,28)26-20-6-7-22-12-23-20)16(21)9-18(13)29-17-5-3-2-4-15(17)14-10-24-25-11-14/h6-12,15,17H,2-5H2,1H3,(H,24,25)(H,22,23,26)/t15-,17+/m0/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258212
PNG
(US9493448, 118)
Show SMILES CCn1nccc1[C@@H]1CCC[C@H]1Oc1ccc(c(F)c1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H21F2N5O3S/c1-2-27-14(8-11-25-27)13-4-3-5-15(13)30-16-6-7-17(20(22)19(16)21)31(28,29)26-18-9-10-23-12-24-18/h6-13,15H,2-5H2,1H3,(H,23,24,26)/t13-,15+/m0/s1
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n/an/a 2.10E+4n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258241
PNG
(US9493448, 149)
Show SMILES Cc1cc(c(F)cc1O[C@@H]1CCC[C@H]1c1ccn[nH]1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C19H20FN5O3S/c1-12-9-18(29(26,27)25-19-6-7-21-11-22-19)14(20)10-17(12)28-16-4-2-3-13(16)15-5-8-23-24-15/h5-11,13,16H,2-4H2,1H3,(H,23,24)(H,21,22,25)/t13-,16+/m0/s1
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n/an/a 3.20E+4n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258243
PNG
(US9493448, 151)
Show SMILES Fc1cc(O[C@@H]2CCC[C@H]2c2ccn[nH]2)c(Cl)cc1S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C18H17ClFN5O3S/c19-12-8-17(29(26,27)25-18-5-6-21-10-22-18)13(20)9-16(12)28-15-3-1-2-11(15)14-4-7-23-24-14/h4-11,15H,1-3H2,(H,23,24)(H,21,22,25)/t11-,15+/m0/s1
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n/an/a 3.30E+4n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258173
PNG
(US9493448, 78)
Show SMILES Cn1nccc1[C@@H]1CCC[C@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C19H19F2N5O3S/c1-26-15(5-8-24-26)12-3-2-4-16(12)29-17-9-14(21)18(10-13(17)20)30(27,28)25-19-6-7-22-11-23-19/h5-12,16H,2-4H2,1H3,(H,22,23,25)/t12-,16+/m0/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258235
PNG
(US9493448, 142)
Show SMILES Cn1nccc1[C@@H]1CCCC[C@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C20H21ClFN5O3S/c1-27-16(6-9-25-27)13-4-2-3-5-17(13)30-18-11-15(22)19(10-14(18)21)31(28,29)26-20-7-8-23-12-24-20/h6-13,17H,2-5H2,1H3,(H,23,24,26)/t13-,17+/m0/s1
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DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258221
PNG
(US9493448, 128)
Show SMILES Cn1nccc1[C@@H]1CCC[C@H]1Oc1ccc(c(F)c1)S(=O)(=O)Nc1ccncn1
Show InChI InChI=1S/C19H20FN5O3S/c1-25-16(7-10-23-25)14-3-2-4-17(14)28-13-5-6-18(15(20)11-13)29(26,27)24-19-8-9-21-12-22-19/h5-12,14,17H,2-4H2,1H3,(H,21,22,24)/t14-,17+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 9.20E+4n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM258245
PNG
(US9493448, 153)
Show SMILES Cn1nccc1[C@H]1CCCC[C@@H]1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccnc(=O)[nH]1
Show InChI InChI=1S/C20H21ClFN5O4S/c1-27-15(6-9-24-27)12-4-2-3-5-16(12)31-17-11-14(22)18(10-13(17)21)32(29,30)26-19-7-8-23-20(28)25-19/h6-12,16H,2-5H2,1H3,(H2,23,25,26,28)/t12-,16+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+5n/an/an/an/an/an/a



DAIICHI SANKYO COMPANY, LIMITED

US Patent


Assay Description
Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%