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Patent code US9493474

Compile Data Set for Download or QSAR
Found 60 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254078
PNG
(US9493474, 10A)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2(CCCN2C[C@H](O)c2ccc3C(=O)OCc3c2C)C1
Show InChI InChI=1S/C29H34N2O6/c1-17-19(4-6-21-23(17)14-36-27(21)34)25(32)12-30-11-9-29(16-30)8-3-10-31(29)13-26(33)20-5-7-22-24(18(20)2)15-37-28(22)35/h4-7,25-26,32-33H,3,8-16H2,1-2H3/t25-,26-,29?/m0/s1
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n/an/a 11n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254081
PNG
(US9493474, 13A)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCCC2(CCCN(C2)C(=O)c2ccc(nc2)-n2cnnn2)C1
Show InChI InChI=1S/C27H31N7O4/c1-18-20(5-6-21-22(18)14-38-26(21)37)23(35)13-32-10-2-8-27(15-32)9-3-11-33(16-27)25(36)19-4-7-24(28-12-19)34-17-29-30-31-34/h4-7,12,17,23,35H,2-3,8-11,13-16H2,1H3/t23-,27?/m0/s1
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n/an/a 31n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254094
PNG
(US9493474, 4B)
Show SMILES Cc1c2COC(=O)c2ccc1[C@H](O)CN1CC2CCN(C[C@@H](O)c3ccc4C(=O)OCc4c3C)C2C1
Show InChI InChI=1S/C28H32N2O6/c1-15-18(3-5-20-22(15)13-35-27(20)33)25(31)11-29-9-17-7-8-30(24(17)10-29)12-26(32)19-4-6-21-23(16(19)2)14-36-28(21)34/h3-6,17,24-26,31-32H,7-14H2,1-2H3/t17?,24?,25-,26-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254079
PNG
(US9493474, 11A)
Show SMILES CC1CC2CN(CC(O)c3ccc(cn3)C#N)CC2N1C[C@H](O)c1ccc2C(=O)OCc2c1C
Show InChI InChI=1S/C26H30N4O4/c1-15-7-18-10-29(12-25(32)22-6-3-17(8-27)9-28-22)11-23(18)30(15)13-24(31)19-4-5-20-21(16(19)2)14-34-26(20)33/h3-6,9,15,18,23-25,31-32H,7,10-14H2,1-2H3/t15?,18?,23?,24-,25?/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254080
PNG
(US9493474, 12A)
Show SMILES CC1CC2CN(C[C@H](O)c3ccc4C(=O)OCc4c3C)CC2N1C[C@H](O)c1ccc2C(=O)OCc2c1C
Show InChI InChI=1S/C29H34N2O6/c1-15-8-18-9-30(11-26(32)19-4-6-21-23(16(19)2)13-36-28(21)34)10-25(18)31(15)12-27(33)20-5-7-22-24(17(20)3)14-37-29(22)35/h4-7,15,18,25-27,32-33H,8-14H2,1-3H3/t15?,18?,25?,26-,27-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254087
PNG
(US9493474, 19A)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2(CCCN2S(=O)(=O)c2ccc(cc2)-n2cnnn2)C1
Show InChI InChI=1S/C25H28N6O5S/c1-17-20(7-8-21-22(17)14-36-24(21)33)23(32)13-29-12-10-25(15-29)9-2-11-31(25)37(34,35)19-5-3-18(4-6-19)30-16-26-27-28-30/h3-8,16,23,32H,2,9-15H2,1H3/t23-,25?/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254075
PNG
(US9493474, 7A)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2CN(CC(O)c3ccc(cn3)C#N)CC12
Show InChI InChI=1S/C25H28N4O4/c1-15-18(3-4-19-20(15)14-33-25(19)32)23(30)13-29-7-6-17-10-28(11-22(17)29)12-24(31)21-5-2-16(8-26)9-27-21/h2-5,9,17,22-24,30-31H,6-7,10-14H2,1H3/t17?,22?,23-,24?/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254098
PNG
(US9493474, 11B)
Show SMILES CC1CC2CN(CC(O)c3ccc(cn3)C#N)CC2N1C[C@@H](O)c1ccc2C(=O)OCc2c1C
Show InChI InChI=1S/C26H30N4O4/c1-15-7-18-10-29(12-25(32)22-6-3-17(8-27)9-28-22)11-23(18)30(15)13-24(31)19-4-5-20-21(16(19)2)14-34-26(20)33/h3-6,9,15,18,23-25,31-32H,7,10-14H2,1-2H3/t15?,18?,23?,24-,25?/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254099
PNG
(US9493474, 12B)
Show SMILES CC1CC2CN(C[C@@H](O)c3ccc4C(=O)OCc4c3C)CC2N1C[C@@H](O)c1ccc2C(=O)OCc2c1C
Show InChI InChI=1S/C29H34N2O6/c1-15-8-18-9-30(11-26(32)19-4-6-21-23(16(19)2)13-36-28(21)34)10-25(18)31(15)12-27(33)20-5-7-22-24(17(20)3)14-37-29(22)35/h4-7,15,18,25-27,32-33H,8-14H2,1-3H3/t15?,18?,25?,26-,27-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254072
PNG
(US9493474, 4A)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CC2CCN(C[C@H](O)c3ccc4C(=O)OCc4c3C)C2C1
Show InChI InChI=1S/C28H32N2O6/c1-15-18(3-5-20-22(15)13-35-27(20)33)25(31)11-29-9-17-7-8-30(24(17)10-29)12-26(32)19-4-6-21-23(16(19)2)14-36-28(21)34/h3-6,17,24-26,31-32H,7-14H2,1-2H3/t17?,24?,25-,26-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254076
PNG
(US9493474, 8A)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2CN(CC12)S(=O)(=O)c1ccc(cc1)C#N
Show InChI InChI=1S/C24H25N3O5S/c1-15-19(6-7-20-21(15)14-32-24(20)29)23(28)13-26-9-8-17-11-27(12-22(17)26)33(30,31)18-4-2-16(10-25)3-5-18/h2-7,17,22-23,28H,8-9,11-14H2,1H3/t17?,22?,23-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254102
PNG
(US9493474, 19B)
Show SMILES Cc1c2COC(=O)c2ccc1[C@H](O)CN1CCC2(CCCN2S(=O)(=O)c2ccc(cc2)-n2cnnn2)C1
Show InChI InChI=1S/C25H28N6O5S/c1-17-20(7-8-21-22(17)14-36-24(21)33)23(32)13-29-12-10-25(15-29)9-2-11-31(25)37(34,35)19-5-3-18(4-6-19)30-16-26-27-28-30/h3-8,16,23,32H,2,9-15H2,1H3/t23-,25?/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254097
PNG
(US9493474, 10B)
Show SMILES Cc1c2COC(=O)c2ccc1[C@H](O)CN1CCC2(CCCN2C[C@@H](O)c2ccc3C(=O)OCc3c2C)C1
Show InChI InChI=1S/C29H34N2O6/c1-17-19(4-6-21-23(17)14-36-27(21)34)25(32)12-30-11-9-29(16-30)8-3-10-31(29)13-26(33)20-5-7-22-24(18(20)2)15-37-28(22)35/h4-7,25-26,32-33H,3,8-16H2,1-2H3/t25-,26-,29?/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254086
PNG
(US9493474, 18A)
Show SMILES Cc1cc(ccc1-n1cnnn1)S(=O)(=O)N1CCCC11CCN(C[C@H](O)c2ccc3C(=O)OCc3c2C)C1
Show InChI InChI=1S/C26H30N6O5S/c1-17-12-19(4-7-23(17)31-16-27-28-29-31)38(35,36)32-10-3-8-26(32)9-11-30(15-26)13-24(33)20-5-6-21-22(18(20)2)14-37-25(21)34/h4-7,12,16,24,33H,3,8-11,13-15H2,1-2H3/t24-,26?/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254080
PNG
(US9493474, 12A)
Show SMILES CC1CC2CN(C[C@H](O)c3ccc4C(=O)OCc4c3C)CC2N1C[C@H](O)c1ccc2C(=O)OCc2c1C
Show InChI InChI=1S/C29H34N2O6/c1-15-8-18-9-30(11-26(32)19-4-6-21-23(16(19)2)13-36-28(21)34)10-25(18)31(15)12-27(33)20-5-7-22-24(17(20)3)14-37-29(22)35/h4-7,15,18,25-27,32-33H,8-14H2,1-3H3/t15?,18?,25?,26-,27-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254081
PNG
(US9493474, 13A)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCCC2(CCCN(C2)C(=O)c2ccc(nc2)-n2cnnn2)C1
Show InChI InChI=1S/C27H31N7O4/c1-18-20(5-6-21-22(18)14-38-26(21)37)23(35)13-32-10-2-8-27(15-32)9-3-11-33(16-27)25(36)19-4-7-24(28-12-19)34-17-29-30-31-34/h4-7,12,17,23,35H,2-3,8-11,13-16H2,1H3/t23-,27?/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254098
PNG
(US9493474, 11B)
Show SMILES CC1CC2CN(CC(O)c3ccc(cn3)C#N)CC2N1C[C@@H](O)c1ccc2C(=O)OCc2c1C
Show InChI InChI=1S/C26H30N4O4/c1-15-7-18-10-29(12-25(32)22-6-3-17(8-27)9-28-22)11-23(18)30(15)13-24(31)19-4-5-20-21(16(19)2)14-34-26(20)33/h3-6,9,15,18,23-25,31-32H,7,10-14H2,1-2H3/t15?,18?,23?,24-,25?/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254078
PNG
(US9493474, 10A)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2(CCCN2C[C@H](O)c2ccc3C(=O)OCc3c2C)C1
Show InChI InChI=1S/C29H34N2O6/c1-17-19(4-6-21-23(17)14-36-27(21)34)25(32)12-30-11-9-29(16-30)8-3-10-31(29)13-26(33)20-5-7-22-24(18(20)2)15-37-28(22)35/h4-7,25-26,32-33H,3,8-16H2,1-2H3/t25-,26-,29?/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254079
PNG
(US9493474, 11A)
Show SMILES CC1CC2CN(CC(O)c3ccc(cn3)C#N)CC2N1C[C@H](O)c1ccc2C(=O)OCc2c1C
Show InChI InChI=1S/C26H30N4O4/c1-15-7-18-10-29(12-25(32)22-6-3-17(8-27)9-28-22)11-23(18)30(15)13-24(31)19-4-5-20-21(16(19)2)14-34-26(20)33/h3-6,9,15,18,23-25,31-32H,7,10-14H2,1-2H3/t15?,18?,23?,24-,25?/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254100
PNG
(US9493474, 13B)
Show SMILES Cc1c2COC(=O)c2ccc1[C@H](O)CN1CCCC2(CCCN(C2)C(=O)c2ccc(nc2)-n2cnnn2)C1
Show InChI InChI=1S/C27H31N7O4/c1-18-20(5-6-21-22(18)14-38-26(21)37)23(35)13-32-10-2-8-27(15-32)9-3-11-33(16-27)25(36)19-4-7-24(28-12-19)34-17-29-30-31-34/h4-7,12,17,23,35H,2-3,8-11,13-16H2,1H3/t23-,27?/m1/s1
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n/an/a 94n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254083
PNG
(US9493474, 15)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CC2CCN(CC2C1)C(=O)c1ccc(nc1)-n1cnnn1
Show InChI InChI=1S/C25H27N7O4/c1-15-19(3-4-20-21(15)13-36-25(20)35)22(33)12-30-9-17-6-7-31(11-18(17)10-30)24(34)16-2-5-23(26-8-16)32-14-27-28-29-32/h2-5,8,14,17-18,22,33H,6-7,9-13H2,1H3/t17?,18?,22-/m0/s1
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n/an/a 103n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254099
PNG
(US9493474, 12B)
Show SMILES CC1CC2CN(C[C@@H](O)c3ccc4C(=O)OCc4c3C)CC2N1C[C@@H](O)c1ccc2C(=O)OCc2c1C
Show InChI InChI=1S/C29H34N2O6/c1-15-8-18-9-30(11-26(32)19-4-6-21-23(16(19)2)13-36-28(21)34)10-25(18)31(15)12-27(33)20-5-7-22-24(17(20)3)14-37-29(22)35/h4-7,15,18,25-27,32-33H,8-14H2,1-3H3/t15?,18?,25?,26-,27-/m1/s1
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n/an/a 105n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254082
PNG
(US9493474, 14)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2(C1)CCCN(C2)C(=O)c1ccc(nc1)-n1cnnn1
Show InChI InChI=1S/C26H29N7O4/c1-17-19(4-5-20-21(17)13-37-25(20)36)22(34)12-31-10-8-26(14-31)7-2-9-32(15-26)24(35)18-3-6-23(27-11-18)33-16-28-29-30-33/h3-6,11,16,22,34H,2,7-10,12-15H2,1H3/t22-,26?/m0/s1
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n/an/a 108n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254069
PNG
(US9493474, 1)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2(C1)CCCN(C[C@H](O)c1ccc3C(=O)OCc3c1C)C2
Show InChI InChI=1S/C30H36N2O6/c1-18-20(4-6-22-24(18)14-37-28(22)35)26(33)12-31-10-3-8-30(16-31)9-11-32(17-30)13-27(34)21-5-7-23-25(19(21)2)15-38-29(23)36/h4-7,26-27,33-34H,3,8-17H2,1-2H3/t26-,27-,30?/m0/s1
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n/an/a 117n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254094
PNG
(US9493474, 4B)
Show SMILES Cc1c2COC(=O)c2ccc1[C@H](O)CN1CC2CCN(C[C@@H](O)c3ccc4C(=O)OCc4c3C)C2C1
Show InChI InChI=1S/C28H32N2O6/c1-15-18(3-5-20-22(15)13-35-27(20)33)25(31)11-29-9-17-7-8-30(24(17)10-29)12-26(32)19-4-6-21-23(16(19)2)14-36-28(21)34/h3-6,17,24-26,31-32H,7-14H2,1-2H3/t17?,24?,25-,26-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254072
PNG
(US9493474, 4A)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CC2CCN(C[C@H](O)c3ccc4C(=O)OCc4c3C)C2C1
Show InChI InChI=1S/C28H32N2O6/c1-15-18(3-5-20-22(15)13-35-27(20)33)25(31)11-29-9-17-7-8-30(24(17)10-29)12-26(32)19-4-6-21-23(16(19)2)14-36-28(21)34/h3-6,17,24-26,31-32H,7-14H2,1-2H3/t17?,24?,25-,26-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254101
PNG
(US9493474, 18B)
Show SMILES Cc1cc(ccc1-n1cnnn1)S(=O)(=O)N1CCCC11CCN(C[C@@H](O)c2ccc3C(=O)OCc3c2C)C1
Show InChI InChI=1S/C26H30N6O5S/c1-17-12-19(4-7-23(17)31-16-27-28-29-31)38(35,36)32-10-3-8-26(32)9-11-30(15-26)13-24(33)20-5-6-21-22(18(20)2)14-37-25(21)34/h4-7,12,16,24,33H,3,8-11,13-15H2,1-2H3/t24-,26?/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254086
PNG
(US9493474, 18A)
Show SMILES Cc1cc(ccc1-n1cnnn1)S(=O)(=O)N1CCCC11CCN(C[C@H](O)c2ccc3C(=O)OCc3c2C)C1
Show InChI InChI=1S/C26H30N6O5S/c1-17-12-19(4-7-23(17)31-16-27-28-29-31)38(35,36)32-10-3-8-26(32)9-11-30(15-26)13-24(33)20-5-6-21-22(18(20)2)14-37-25(21)34/h4-7,12,16,24,33H,3,8-11,13-15H2,1-2H3/t24-,26?/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254075
PNG
(US9493474, 7A)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2CN(CC(O)c3ccc(cn3)C#N)CC12
Show InChI InChI=1S/C25H28N4O4/c1-15-18(3-4-19-20(15)14-33-25(19)32)23(30)13-29-7-6-17-10-28(11-22(17)29)12-24(31)21-5-2-16(8-26)9-27-21/h2-5,9,17,22-24,30-31H,6-7,10-14H2,1H3/t17?,22?,23-,24?/m0/s1
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n/an/a 153n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254097
PNG
(US9493474, 10B)
Show SMILES Cc1c2COC(=O)c2ccc1[C@H](O)CN1CCC2(CCCN2C[C@@H](O)c2ccc3C(=O)OCc3c2C)C1
Show InChI InChI=1S/C29H34N2O6/c1-17-19(4-6-21-23(17)14-36-27(21)34)25(32)12-30-11-9-29(16-30)8-3-10-31(29)13-26(33)20-5-7-22-24(18(20)2)15-37-28(22)35/h4-7,25-26,32-33H,3,8-16H2,1-2H3/t25-,26-,29?/m1/s1
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n/an/a 184n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254083
PNG
(US9493474, 15)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CC2CCN(CC2C1)C(=O)c1ccc(nc1)-n1cnnn1
Show InChI InChI=1S/C25H27N7O4/c1-15-19(3-4-20-21(15)13-36-25(20)35)22(33)12-30-9-17-6-7-31(11-18(17)10-30)24(34)16-2-5-23(26-8-16)32-14-27-28-29-32/h2-5,8,14,17-18,22,33H,6-7,9-13H2,1H3/t17?,18?,22-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254074
PNG
(US9493474, 6)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCCC2(CCCN(C[C@H](O)c3ccc4C(=O)OCc4c3C)C2)C1
Show InChI InChI=1S/C31H38N2O6/c1-19-21(5-7-23-25(19)15-38-29(23)36)27(34)13-32-11-3-9-31(17-32)10-4-12-33(18-31)14-28(35)22-6-8-24-26(20(22)2)16-39-30(24)37/h5-8,27-28,34-35H,3-4,9-18H2,1-2H3/t27-,28-,31?/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254077
PNG
(US9493474, 9)
Show SMILES O[C@@H](CN1CC2CCN(C2C1)S(=O)(=O)c1ccc(cc1)[N+]#[C-])c1ccc2C(=O)OCc2c1
Show InChI InChI=1S/C23H23N3O5S/c1-24-18-3-5-19(6-4-18)32(29,30)26-9-8-16-11-25(12-21(16)26)13-22(27)15-2-7-20-17(10-15)14-31-23(20)28/h2-7,10,16,21-22,27H,8-9,11-14H2/t16?,21?,22-/m0/s1
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n/an/a 234n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254082
PNG
(US9493474, 14)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2(C1)CCCN(C2)C(=O)c1ccc(nc1)-n1cnnn1
Show InChI InChI=1S/C26H29N7O4/c1-17-19(4-5-20-21(17)13-37-25(20)36)22(34)12-31-10-8-26(14-31)7-2-9-32(15-26)24(35)18-3-6-23(27-11-18)33-16-28-29-30-33/h3-6,11,16,22,34H,2,7-10,12-15H2,1H3/t22-,26?/m0/s1
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n/an/a 241n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254085
PNG
(US9493474, 17)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2CN(CC12)C(=O)c1ccc(nc1)-n1cnnn1
Show InChI InChI=1S/C24H25N7O4/c1-14-17(3-4-18-19(14)12-35-24(18)34)21(32)11-29-7-6-16-9-30(10-20(16)29)23(33)15-2-5-22(25-8-15)31-13-26-27-28-31/h2-5,8,13,16,20-21,32H,6-7,9-12H2,1H3/t16?,20?,21-/m0/s1
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n/an/a 270n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254069
PNG
(US9493474, 1)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2(C1)CCCN(C[C@H](O)c1ccc3C(=O)OCc3c1C)C2
Show InChI InChI=1S/C30H36N2O6/c1-18-20(4-6-22-24(18)14-37-28(22)35)26(33)12-31-10-3-8-30(16-31)9-11-32(17-30)13-27(34)21-5-7-23-25(19(21)2)15-38-29(23)36/h4-7,26-27,33-34H,3,8-17H2,1-2H3/t26-,27-,30?/m0/s1
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n/an/a 274n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254102
PNG
(US9493474, 19B)
Show SMILES Cc1c2COC(=O)c2ccc1[C@H](O)CN1CCC2(CCCN2S(=O)(=O)c2ccc(cc2)-n2cnnn2)C1
Show InChI InChI=1S/C25H28N6O5S/c1-17-20(7-8-21-22(17)14-36-24(21)33)23(32)13-29-12-10-25(15-29)9-2-11-31(25)37(34,35)19-5-3-18(4-6-19)30-16-26-27-28-30/h3-8,16,23,32H,2,9-15H2,1H3/t23-,25?/m1/s1
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n/an/a 285n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254087
PNG
(US9493474, 19A)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2(CCCN2S(=O)(=O)c2ccc(cc2)-n2cnnn2)C1
Show InChI InChI=1S/C25H28N6O5S/c1-17-20(7-8-21-22(17)14-36-24(21)33)23(32)13-29-12-10-25(15-29)9-2-11-31(25)37(34,35)19-5-3-18(4-6-19)30-16-26-27-28-30/h3-8,16,23,32H,2,9-15H2,1H3/t23-,25?/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254101
PNG
(US9493474, 18B)
Show SMILES Cc1cc(ccc1-n1cnnn1)S(=O)(=O)N1CCCC11CCN(C[C@@H](O)c2ccc3C(=O)OCc3c2C)C1
Show InChI InChI=1S/C26H30N6O5S/c1-17-12-19(4-7-23(17)31-16-27-28-29-31)38(35,36)32-10-3-8-26(32)9-11-30(15-26)13-24(33)20-5-6-21-22(18(20)2)14-37-25(21)34/h4-7,12,16,24,33H,3,8-11,13-15H2,1-2H3/t24-,26?/m1/s1
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n/an/a 294n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254089
PNG
(US9493474, 21)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCCC2(CCCN(C2)C(=O)c2ccc(nc2)S(C)(=O)=O)C1
Show InChI InChI=1S/C27H33N3O6S/c1-18-20(6-7-21-22(18)15-36-26(21)33)23(31)14-29-11-3-9-27(16-29)10-4-12-30(17-27)25(32)19-5-8-24(28-13-19)37(2,34)35/h5-8,13,23,31H,3-4,9-12,14-17H2,1-2H3/t23-,27?/m0/s1
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n/an/a 319n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254073
PNG
(US9493474, 5)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCCC11CCCN(C[C@H](O)c2ccc3C(=O)OCc3c2C)C1
Show InChI InChI=1S/C30H36N2O6/c1-18-20(5-7-22-24(18)15-37-28(22)35)26(33)13-31-11-3-9-30(17-31)10-4-12-32(30)14-27(34)21-6-8-23-25(19(21)2)16-38-29(23)36/h5-8,26-27,33-34H,3-4,9-17H2,1-2H3/t26-,27-,30?/m0/s1
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n/an/a 348n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254074
PNG
(US9493474, 6)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCCC2(CCCN(C[C@H](O)c3ccc4C(=O)OCc4c3C)C2)C1
Show InChI InChI=1S/C31H38N2O6/c1-19-21(5-7-23-25(19)15-38-29(23)36)27(34)13-32-11-3-9-31(17-32)10-4-12-33(18-31)14-28(35)22-6-8-24-26(20(22)2)16-39-30(24)37/h5-8,27-28,34-35H,3-4,9-18H2,1-2H3/t27-,28-,31?/m0/s1
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n/an/a 359n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254076
PNG
(US9493474, 8A)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2CN(CC12)S(=O)(=O)c1ccc(cc1)C#N
Show InChI InChI=1S/C24H25N3O5S/c1-15-19(6-7-20-21(15)14-32-24(20)29)23(28)13-26-9-8-17-11-27(12-22(17)26)33(30,31)18-4-2-16(10-25)3-5-18/h2-7,17,22-23,28H,8-9,11-14H2,1H3/t17?,22?,23-/m0/s1
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n/an/a 402n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254091
PNG
(US9493474, 23)
Show SMILES Cc1c2COC(=O)c2ccc1[C@H](O)CN1CC2CN(CC(O)c3ccc(cn3)C#N)C2C1
Show InChI InChI=1S/C24H26N4O4/c1-14-17(3-4-18-19(14)13-32-24(18)31)22(29)11-27-8-16-9-28(21(16)10-27)12-23(30)20-5-2-15(6-25)7-26-20/h2-5,7,16,21-23,29-30H,8-13H2,1H3/t16?,21?,22-,23?/m1/s1
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n/an/a 540n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254085
PNG
(US9493474, 17)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2CN(CC12)C(=O)c1ccc(nc1)-n1cnnn1
Show InChI InChI=1S/C24H25N7O4/c1-14-17(3-4-18-19(14)12-35-24(18)34)21(32)11-29-7-6-16-9-30(10-20(16)29)23(33)15-2-5-22(25-8-15)31-13-26-27-28-31/h2-5,8,13,16,20-21,32H,6-7,9-12H2,1H3/t16?,20?,21-/m0/s1
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n/an/a 543n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254095
PNG
(US9493474, 7B)
Show SMILES Cc1c2COC(=O)c2ccc1[C@H](O)CN1CCC2CN(CC(O)c3ccc(cn3)C#N)CC12
Show InChI InChI=1S/C25H28N4O4/c1-15-18(3-4-19-20(15)14-33-25(19)32)23(30)13-29-7-6-17-10-28(11-22(17)29)12-24(31)21-5-2-16(8-26)9-27-21/h2-5,9,17,22-24,30-31H,6-7,10-14H2,1H3/t17?,22?,23-,24?/m1/s1
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n/an/a 566n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254084
PNG
(US9493474, 16)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2CN(CC12)C(=O)c1ccc(cn1)-n1cnnn1
Show InChI InChI=1S/C24H25N7O4/c1-14-17(3-4-18-19(14)12-35-24(18)34)22(32)11-29-7-6-15-9-30(10-21(15)29)23(33)20-5-2-16(8-25-20)31-13-26-27-28-31/h2-5,8,13,15,21-22,32H,6-7,9-12H2,1H3/t15?,21?,22-/m0/s1
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n/an/a 602n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254096
PNG
(US9493474, 8B)
Show SMILES Cc1c2COC(=O)c2ccc1[C@H](O)CN1CCC2CN(CC12)S(=O)(=O)c1ccc(cc1)C#N
Show InChI InChI=1S/C24H25N3O5S/c1-15-19(6-7-20-21(15)14-32-24(20)29)23(28)13-26-9-8-17-11-27(12-22(17)26)33(30,31)18-4-2-16(10-25)3-5-18/h2-7,17,22-23,28H,8-9,11-14H2,1H3/t17?,22?,23-/m1/s1
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n/an/a 662n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254100
PNG
(US9493474, 13B)
Show SMILES Cc1c2COC(=O)c2ccc1[C@H](O)CN1CCCC2(CCCN(C2)C(=O)c2ccc(nc2)-n2cnnn2)C1
Show InChI InChI=1S/C27H31N7O4/c1-18-20(5-6-21-22(18)14-38-26(21)37)23(35)13-32-10-2-8-27(15-32)9-3-11-33(16-27)25(36)19-4-7-24(28-12-19)34-17-29-30-31-34/h4-7,12,17,23,35H,2-3,8-11,13-16H2,1H3/t23-,27?/m1/s1
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n/an/a 728n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254073
PNG
(US9493474, 5)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCCC11CCCN(C[C@H](O)c2ccc3C(=O)OCc3c2C)C1
Show InChI InChI=1S/C30H36N2O6/c1-18-20(5-7-22-24(18)15-37-28(22)35)26(33)13-31-11-3-9-30(17-31)10-4-12-32(30)14-27(34)21-6-8-23-25(19(21)2)16-38-29(23)36/h5-8,26-27,33-34H,3-4,9-17H2,1-2H3/t26-,27-,30?/m0/s1
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n/an/a 737n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254092
PNG
(US9493474, 24)
Show SMILES COc1cc(ncc1C#N)C(O)CN1CC2CN(C[C@H](O)c3ccc4C(=O)OCc4c3C)C2C1
Show InChI InChI=1S/C25H28N4O5/c1-14-17(3-4-18-19(14)13-34-25(18)32)22(30)12-29-9-16-8-28(10-21(16)29)11-23(31)20-5-24(33-2)15(6-26)7-27-20/h3-5,7,16,21-23,30-31H,8-13H2,1-2H3/t16?,21?,22-,23?/m0/s1
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n/an/a 789n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254084
PNG
(US9493474, 16)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2CN(CC12)C(=O)c1ccc(cn1)-n1cnnn1
Show InChI InChI=1S/C24H25N7O4/c1-14-17(3-4-18-19(14)12-35-24(18)34)22(32)11-29-7-6-15-9-30(10-21(15)29)23(33)20-5-2-16(8-25-20)31-13-26-27-28-31/h2-5,8,13,15,21-22,32H,6-7,9-12H2,1H3/t15?,21?,22-/m0/s1
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n/an/a 850n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254071
PNG
(US9493474, 3)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CC2CCN(CC2C1)C(=O)c1ccc(cn1)C#N
Show InChI InChI=1S/C25H26N4O4/c1-15-19(3-4-20-21(15)14-33-25(20)32)23(30)13-28-10-17-6-7-29(12-18(17)11-28)24(31)22-5-2-16(8-26)9-27-22/h2-5,9,17-18,23,30H,6-7,10-14H2,1H3/t17?,18?,23-/m0/s1
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n/an/a 865n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254090
PNG
(US9493474, 22)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CC2CN(CC(O)c3ccc(cn3)C#N)C2C1
Show InChI InChI=1S/C24H26N4O4/c1-14-17(3-4-18-19(14)13-32-24(18)31)22(29)11-27-8-16-9-28(21(16)10-27)12-23(30)20-5-2-15(6-25)7-26-20/h2-5,7,16,21-23,29-30H,8-13H2,1H3/t16?,21?,22-,23?/m0/s1
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n/an/a 916n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254089
PNG
(US9493474, 21)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCCC2(CCCN(C2)C(=O)c2ccc(nc2)S(C)(=O)=O)C1
Show InChI InChI=1S/C27H33N3O6S/c1-18-20(6-7-21-22(18)15-36-26(21)33)23(31)14-29-11-3-9-27(16-29)10-4-12-30(17-27)25(32)19-5-8-24(28-13-19)37(2,34)35/h5-8,13,23,31H,3-4,9-12,14-17H2,1-2H3/t23-,27?/m0/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254088
PNG
(US9493474, 20)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2CN(CC12)S(=O)(=O)c1ccc(cc1)-n1cnnn1
Show InChI InChI=1S/C24H26N6O5S/c1-15-19(6-7-20-21(15)13-35-24(20)32)23(31)12-28-9-8-16-10-29(11-22(16)28)36(33,34)18-4-2-17(3-5-18)30-14-25-26-27-30/h2-7,14,16,22-23,31H,8-13H2,1H3/t16?,22?,23-/m0/s1
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n/an/a 1.05E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254070
PNG
(US9493474, 2)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2(C1)CCN(C[C@H](O)c1ccc3C(=O)OCc3c1C)CC2
Show InChI InChI=1S/C30H36N2O6/c1-18-20(3-5-22-24(18)15-37-28(22)35)26(33)13-31-10-7-30(8-11-31)9-12-32(17-30)14-27(34)21-4-6-23-25(19(21)2)16-38-29(23)36/h3-6,26-27,33-34H,7-17H2,1-2H3/t26-,27-/m0/s1
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n/an/a 1.21E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254093
PNG
(US9493474, 25)
Show SMILES COc1cc(ncc1C#N)C(O)CN1CC2CN(C[C@@H](O)c3ccc4C(=O)OCc4c3C)C2C1
Show InChI InChI=1S/C25H28N4O5/c1-14-17(3-4-18-19(14)13-34-25(18)32)22(30)12-29-9-16-8-28(10-21(16)29)11-23(31)20-5-24(33-2)15(6-26)7-27-20/h3-5,7,16,21-23,30-31H,8-13H2,1-2H3/t16?,21?,22-,23?/m1/s1
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n/an/a 1.28E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...


Citation and Details
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254091
PNG
(US9493474, 23)
Show SMILES Cc1c2COC(=O)c2ccc1[C@H](O)CN1CC2CN(CC(O)c3ccc(cn3)C#N)C2C1
Show InChI InChI=1S/C24H26N4O4/c1-14-17(3-4-18-19(14)13-32-24(18)31)22(29)11-27-8-16-9-28(21(16)10-27)12-23(30)20-5-2-15(6-25)7-26-20/h2-5,7,16,21-23,29-30H,8-13H2,1H3/t16?,21?,22-,23?/m1/s1
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UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 1.80E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


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More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM254095
PNG
(US9493474, 7B)
Show SMILES Cc1c2COC(=O)c2ccc1[C@H](O)CN1CCC2CN(CC(O)c3ccc(cn3)C#N)CC12
Show InChI InChI=1S/C25H28N4O4/c1-15-18(3-4-19-20(15)14-33-25(19)32)23(30)13-29-7-6-17-10-28(11-22(17)29)12-24(31)21-5-2-16(8-26)9-27-21/h2-5,9,17,22-24,30-31H,6-7,10-14H2,1H3/t17?,22?,23-,24?/m1/s1
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UniChem
US Patent
n/an/a 2.40E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%