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Patent code US9493485

Compile Data Set for Download or QSAR
Found 178 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Beta-secretase 1


(Homo sapiens (Human))
BDBM258304
PNG
(US9493485, 9-145)
Show SMILES C[C@]1(CC2(CCC2)SC(N)=N1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F
Show InChI InChI=1S/C20H20ClFN4OS/c1-19(11-20(7-2-8-20)28-18(23)26-19)14-9-13(4-5-15(14)22)25-17(27)16-6-3-12(21)10-24-16/h3-6,9-10H,2,7-8,11H2,1H3,(H2,23,26)(H,25,27)/t19-/m0/s1
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US Patent
n/an/a 1.90n/an/an/an/an/an/a



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258329
PNG
(US9493485, 13-182)
Show SMILES COc1cccnc1Nc1ccc(F)c(c1)[C@]1(C)CC2(CCOCC2)SC(N)=N1
Show InChI InChI=1S/C21H25FN4O2S/c1-20(13-21(29-19(23)26-20)7-10-28-11-8-21)15-12-14(5-6-16(15)22)25-18-17(27-2)4-3-9-24-18/h3-6,9,12H,7-8,10-11,13H2,1-2H3,(H2,23,26)(H,24,25)/t20-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258287
PNG
(US9493485, 9-128)
Show SMILES C[C@]1(CC2(CCOCC2)OC(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C21H22F2N4O3/c1-20(12-21(30-19(24)27-20)6-8-29-9-7-21)15-10-14(3-4-16(15)23)26-18(28)17-5-2-13(22)11-25-17/h2-5,10-11H,6-9,12H2,1H3,(H2,24,27)(H,26,28)/t20-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258309
PNG
(US9493485, 9-150)
Show SMILES CC1(CC2(CCOCC2)SC(N)=N1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F
Show InChI InChI=1S/C21H22ClFN4O2S/c1-20(12-21(30-19(24)27-20)6-8-29-9-7-21)15-10-14(3-4-16(15)23)26-18(28)17-5-2-13(22)11-25-17/h2-5,10-11H,6-9,12H2,1H3,(H2,24,27)(H,26,28)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258304
PNG
(US9493485, 9-145)
Show SMILES C[C@]1(CC2(CCC2)SC(N)=N1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F
Show InChI InChI=1S/C20H20ClFN4OS/c1-19(11-20(7-2-8-20)28-18(23)26-19)14-9-13(4-5-15(14)22)25-17(27)16-6-3-12(21)10-24-16/h3-6,9-10H,2,7-8,11H2,1H3,(H2,23,26)(H,25,27)/t19-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258283
PNG
(US9493485, 9-124)
Show SMILES C[C@]1(CC2(CCC(F)(F)CC2)OC(N)=N1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F
Show InChI InChI=1S/C22H22ClF3N4O2/c1-20(12-21(32-19(27)30-20)6-8-22(25,26)9-7-21)15-10-14(3-4-16(15)24)29-18(31)17-5-2-13(23)11-28-17/h2-5,10-11H,6-9,12H2,1H3,(H2,27,30)(H,29,31)/t20-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258310
PNG
(US9493485, 9-151)
Show SMILES C[C@]1(CC2(CCOCC2)SC(N)=N1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F
Show InChI InChI=1S/C21H22ClFN4O2S/c1-20(12-21(30-19(24)27-20)6-8-29-9-7-21)15-10-14(3-4-16(15)23)26-18(28)17-5-2-13(22)11-25-17/h2-5,10-11H,6-9,12H2,1H3,(H2,24,27)(H,26,28)/t20-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258290
PNG
(US9493485, 9-131)
Show SMILES C[C@]1(CC2(CCC2)OC(N)=N1)c1cc(NC(=O)c2ncc(Cl)cc2F)ccc1F
Show InChI InChI=1S/C20H19ClF2N4O2/c1-19(10-20(5-2-6-20)29-18(24)27-19)13-8-12(3-4-14(13)22)26-17(28)16-15(23)7-11(21)9-25-16/h3-4,7-9H,2,5-6,10H2,1H3,(H2,24,27)(H,26,28)/t19-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258289
PNG
(US9493485, 9-130)
Show SMILES C[C@]1(CC2(CCC2)OC(N)=N1)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F
Show InChI InChI=1S/C21H20FN5O2/c1-20(12-21(7-2-8-21)29-19(24)27-20)15-9-14(4-5-16(15)22)26-18(28)17-6-3-13(10-23)11-25-17/h3-6,9,11H,2,7-8,12H2,1H3,(H2,24,27)(H,26,28)/t20-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258291
PNG
(US9493485, 9-132)
Show SMILES C[C@]1(CC2(CCC(F)(F)CC2)OC(N)=N1)c1cc(NC(=O)c2ccc(cn2)C(F)(F)F)ccc1F
Show InChI InChI=1S/C23H22F6N4O2/c1-20(12-21(35-19(30)33-20)6-8-22(25,26)9-7-21)15-10-14(3-4-16(15)24)32-18(34)17-5-2-13(11-31-17)23(27,28)29/h2-5,10-11H,6-9,12H2,1H3,(H2,30,33)(H,32,34)/t20-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258301
PNG
(US9493485, 9-142)
Show SMILES CC1(CC2(CCCCC2)SC(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C22H24F2N4OS/c1-21(13-22(30-20(25)28-21)9-3-2-4-10-22)16-11-15(6-7-17(16)24)27-19(29)18-8-5-14(23)12-26-18/h5-8,11-12H,2-4,9-10,13H2,1H3,(H2,25,28)(H,27,29)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258307
PNG
(US9493485, 9-148)
Show SMILES C[C@]1(CC2(CCOCC2)SC(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C21H22F2N4O2S/c1-20(12-21(30-19(24)27-20)6-8-29-9-7-21)15-10-14(3-4-16(15)23)26-18(28)17-5-2-13(22)11-25-17/h2-5,10-11H,6-9,12H2,1H3,(H2,24,27)(H,26,28)/t20-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258277
PNG
(US9493485, 8-113)
Show SMILES CC#Cc1cncc(c1)-c1csc(c1)C1(C)CC2(CCOCC2)SC(N)=N1
Show InChI InChI=1S/C21H23N3OS2/c1-3-4-15-9-16(12-23-11-15)17-10-18(26-13-17)20(2)14-21(27-19(22)24-20)5-7-25-8-6-21/h9-13H,5-8,14H2,1-2H3,(H2,22,24)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258295
PNG
(US9493485, 9-136)
Show SMILES C[C@]1(CC2(CCC(F)(F)CC2)OC(N)=N1)c1cc(NC(=O)c2ccc(Br)cn2)ccc1F
Show InChI InChI=1S/C22H22BrF3N4O2/c1-20(12-21(32-19(27)30-20)6-8-22(25,26)9-7-21)15-10-14(3-4-16(15)24)29-18(31)17-5-2-13(23)11-28-17/h2-5,10-11H,6-9,12H2,1H3,(H2,27,30)(H,29,31)/t20-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258313
PNG
(US9493485, 9-154)
Show SMILES C[C@]1(CC2(CC2)OC(N)=N1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F
Show InChI InChI=1S/C19H18ClFN4O2/c1-18(10-19(6-7-19)27-17(22)25-18)13-8-12(3-4-14(13)21)24-16(26)15-5-2-11(20)9-23-15/h2-5,8-9H,6-7,10H2,1H3,(H2,22,25)(H,24,26)/t18-/m0/s1
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n/an/a 7.5n/an/an/an/an/an/a



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258306
PNG
(US9493485, 9-147)
Show SMILES CC1(CC2(CCOCC2)SC(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C21H22F2N4O2S/c1-20(12-21(30-19(24)27-20)6-8-29-9-7-21)15-10-14(3-4-16(15)23)26-18(28)17-5-2-13(22)11-25-17/h2-5,10-11H,6-9,12H2,1H3,(H2,24,27)(H,26,28)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258303
PNG
(US9493485, 9-144)
Show SMILES C[C@]1(CC2(CCC2)SC(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C20H20F2N4OS/c1-19(11-20(7-2-8-20)28-18(23)26-19)14-9-13(4-5-15(14)22)25-17(27)16-6-3-12(21)10-24-16/h3-6,9-10H,2,7-8,11H2,1H3,(H2,23,26)(H,25,27)/t19-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258288
PNG
(US9493485, 9-129)
Show SMILES C[C@]1(CC2(CCC2)OC(N)=N1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F
Show InChI InChI=1S/C20H20ClFN4O2/c1-19(11-20(7-2-8-20)28-18(23)26-19)14-9-13(4-5-15(14)22)25-17(27)16-6-3-12(21)10-24-16/h3-6,9-10H,2,7-8,11H2,1H3,(H2,23,26)(H,25,27)/t19-/m0/s1
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n/an/a 8.30n/an/an/an/an/an/a



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258282
PNG
(US9493485, 9-123)
Show SMILES C[C@]1(CC2(CCC(F)(F)CC2)OC(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C22H22F4N4O2/c1-20(12-21(32-19(27)30-20)6-8-22(25,26)9-7-21)15-10-14(3-4-16(15)24)29-18(31)17-5-2-13(23)11-28-17/h2-5,10-11H,6-9,12H2,1H3,(H2,27,30)(H,29,31)/t20-/m0/s1
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n/an/a 8.70n/an/an/an/an/an/a



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258292
PNG
(US9493485, 9-133)
Show SMILES C[C@]1(CC2(CCC(F)(F)CC2)OC(N)=N1)c1cc(NC(=O)c2ncc(Cl)cc2F)ccc1F
Show InChI InChI=1S/C22H21ClF4N4O2/c1-20(11-21(33-19(28)31-20)4-6-22(26,27)7-5-21)14-9-13(2-3-15(14)24)30-18(32)17-16(25)8-12(23)10-29-17/h2-3,8-10H,4-7,11H2,1H3,(H2,28,31)(H,30,32)/t20-/m0/s1
PDB
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n/an/a 9n/an/an/an/an/an/a



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258280
PNG
(US9493485, 9-121)
Show SMILES CC1(CC2(CCOCC2)OC(N)=N1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F
Show InChI InChI=1S/C21H22ClFN4O3/c1-20(12-21(30-19(24)27-20)6-8-29-9-7-21)15-10-14(3-4-16(15)23)26-18(28)17-5-2-13(22)11-25-17/h2-5,10-11H,6-9,12H2,1H3,(H2,24,27)(H,26,28)
PDB
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UniProtKB/SwissProt

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n/an/a 9n/an/an/an/an/an/a



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


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More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258309
PNG
(US9493485, 9-150)
Show SMILES CC1(CC2(CCOCC2)SC(N)=N1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F
Show InChI InChI=1S/C21H22ClFN4O2S/c1-20(12-21(30-19(24)27-20)6-8-29-9-7-21)15-10-14(3-4-16(15)23)26-18(28)17-5-2-13(22)11-25-17/h2-5,10-11H,6-9,12H2,1H3,(H2,24,27)(H,26,28)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258298
PNG
(US9493485, 9-139)
Show SMILES CC1(CC2(CCOCC2)OC(N)=N1)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F
Show InChI InChI=1S/C22H22FN5O3/c1-21(13-22(31-20(25)28-21)6-8-30-9-7-22)16-10-15(3-4-17(16)23)27-19(29)18-5-2-14(11-24)12-26-18/h2-5,10,12H,6-9,13H2,1H3,(H2,25,28)(H,27,29)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258310
PNG
(US9493485, 9-151)
Show SMILES C[C@]1(CC2(CCOCC2)SC(N)=N1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F
Show InChI InChI=1S/C21H22ClFN4O2S/c1-20(12-21(30-19(24)27-20)6-8-29-9-7-21)15-10-14(3-4-16(15)23)26-18(28)17-5-2-13(22)11-25-17/h2-5,10-11H,6-9,12H2,1H3,(H2,24,27)(H,26,28)/t20-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258305
PNG
(US9493485, 9-146)
Show SMILES C[C@]1(CC2(COC2)SC(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C19H18F2N4O2S/c1-18(8-19(9-27-10-19)28-17(22)25-18)13-6-12(3-4-14(13)21)24-16(26)15-5-2-11(20)7-23-15/h2-7H,8-10H2,1H3,(H2,22,25)(H,24,26)/t18-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258294
PNG
(US9493485, 9-135)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CC2(CCC2)OC(N)=N1
Show InChI InChI=1S/C20H22FN5O3/c1-19(11-20(6-3-7-20)29-18(22)26-19)13-8-12(4-5-14(13)21)25-17(27)15-9-24-16(28-2)10-23-15/h4-5,8-10H,3,6-7,11H2,1-2H3,(H2,22,26)(H,25,27)/t19-/m0/s1
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US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258285
PNG
(US9493485, 9-126)
Show SMILES C[C@]1(CC2(CCC2)OC(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C20H20F2N4O2/c1-19(11-20(7-2-8-20)28-18(23)26-19)14-9-13(4-5-15(14)22)25-17(27)16-6-3-12(21)10-24-16/h3-6,9-10H,2,7-8,11H2,1H3,(H2,23,26)(H,25,27)/t19-/m0/s1
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Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258297
PNG
(US9493485, 9-138)
Show SMILES Cc1nc(co1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CC2(CCC2)OC(N)=N1
Show InChI InChI=1S/C19H21FN4O3/c1-11-22-15(9-26-11)16(25)23-12-4-5-14(20)13(8-12)18(2)10-19(6-3-7-19)27-17(21)24-18/h4-5,8-9H,3,6-7,10H2,1-2H3,(H2,21,24)(H,23,25)/t18-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258281
PNG
(US9493485, 9-122)
Show SMILES C[C@]1(CC2(CCOCC2)OC(N)=N1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F
Show InChI InChI=1S/C21H22ClFN4O3/c1-20(12-21(30-19(24)27-20)6-8-29-9-7-21)15-10-14(3-4-16(15)23)26-18(28)17-5-2-13(22)11-25-17/h2-5,10-11H,6-9,12H2,1H3,(H2,24,27)(H,26,28)/t20-/m0/s1
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Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258320
PNG
(US9493485, 9-161)
Show SMILES CC1(N=C(N)OC2(CCC2)C1(F)F)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F
Show InChI InChI=1S/C21H18F3N5O2/c1-19(21(23,24)20(7-2-8-20)31-18(26)29-19)14-9-13(4-5-15(14)22)28-17(30)16-6-3-12(10-25)11-27-16/h3-6,9,11H,2,7-8H2,1H3,(H2,26,29)(H,28,30)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258317
PNG
(US9493485, 9-158)
Show SMILES CC1(N=C(N)OC2(CCOCC2)C1(F)F)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F
Show InChI InChI=1S/C21H20ClF3N4O3/c1-19(21(24,25)20(32-18(26)29-19)6-8-31-9-7-20)14-10-13(3-4-15(14)23)28-17(30)16-5-2-12(22)11-27-16/h2-5,10-11H,6-9H2,1H3,(H2,26,29)(H,28,30)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258321
PNG
(US9493485, 9-162)
Show SMILES C[C@@]1(N=C(N)OC2(CCC2)C1(F)F)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F
Show InChI InChI=1S/C21H18F3N5O2/c1-19(21(23,24)20(7-2-8-20)31-18(26)29-19)14-9-13(4-5-15(14)22)28-17(30)16-6-3-12(10-25)11-27-16/h3-6,9,11H,2,7-8H2,1H3,(H2,26,29)(H,28,30)/t19-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258292
PNG
(US9493485, 9-133)
Show SMILES C[C@]1(CC2(CCC(F)(F)CC2)OC(N)=N1)c1cc(NC(=O)c2ncc(Cl)cc2F)ccc1F
Show InChI InChI=1S/C22H21ClF4N4O2/c1-20(11-21(33-19(28)31-20)4-6-22(26,27)7-5-21)14-9-13(2-3-15(14)24)30-18(32)17-16(25)8-12(23)10-29-17/h2-3,8-10H,4-7,11H2,1H3,(H2,28,31)(H,30,32)/t20-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258268
PNG
(US9493485, 8-104)
Show SMILES CC#Cc1cncc(c1)-c1csc(c1)[C@]1(C)CC2(CCOCC2)OC(N)=N1
Show InChI InChI=1S/C21H23N3O2S/c1-3-4-15-9-16(12-23-11-15)17-10-18(27-13-17)20(2)14-21(26-19(22)24-20)5-7-25-8-6-21/h9-13H,5-8,14H2,1-2H3,(H2,22,24)/t20-/m0/s1
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Imago Pharmaceuticals, Inc.

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Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258276
PNG
(US9493485, 8-112)
Show SMILES CC#Cc1cncc(c1)-c1csc(c1)C1(C)CC2(COC2)OC(N)=N1
Show InChI InChI=1S/C19H19N3O2S/c1-3-4-13-5-14(8-21-7-13)15-6-16(25-9-15)18(2)10-19(11-23-12-19)24-17(20)22-18/h5-9H,10-12H2,1-2H3,(H2,20,22)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258296
PNG
(US9493485, 9-137)
Show SMILES C[C@]1(CC2(CCC(F)(F)CC2)OC(N)=N1)c1cc(NC(=O)c2ccc(cn2)C2CC2)ccc1F
Show InChI InChI=1S/C25H27F3N4O2/c1-23(14-24(34-22(29)32-23)8-10-25(27,28)11-9-24)18-12-17(5-6-19(18)26)31-21(33)20-7-4-16(13-30-20)15-2-3-15/h4-7,12-13,15H,2-3,8-11,14H2,1H3,(H2,29,32)(H,31,33)/t23-/m0/s1
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Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258272
PNG
(US9493485, 8-108)
Show SMILES CC#Cc1cncc(c1)-c1cc(sc1C)[C@]1(C)CC2(CCOCC2)OC(N)=N1
Show InChI InChI=1S/C22H25N3O2S/c1-4-5-16-10-17(13-24-12-16)18-11-19(28-15(18)2)21(3)14-22(27-20(23)25-21)6-8-26-9-7-22/h10-13H,6-9,14H2,1-3H3,(H2,23,25)/t21-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258300
PNG
(US9493485, 9-141)
Show SMILES C[C@]1(CC2(CCC2)OC(N)=N1)c1cc(NC(=O)c2ccc(Cl)cc2)ccc1F
Show InChI InChI=1S/C21H21ClFN3O2/c1-20(12-21(9-2-10-21)28-19(24)26-20)16-11-15(7-8-17(16)23)25-18(27)13-3-5-14(22)6-4-13/h3-8,11H,2,9-10,12H2,1H3,(H2,24,26)(H,25,27)/t20-/m0/s1
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US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258279
PNG
(US9493485, 9-120)
Show SMILES CC1(CC2(CCOCC2)OC(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C21H22F2N4O3/c1-20(12-21(30-19(24)27-20)6-8-29-9-7-21)15-10-14(3-4-16(15)23)26-18(28)17-5-2-13(22)11-25-17/h2-5,10-11H,6-9,12H2,1H3,(H2,24,27)(H,26,28)
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Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258319
PNG
(US9493485, 9-160)
Show SMILES CC1(N=C(N)OC2(CCC2)C1(F)F)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F
Show InChI InChI=1S/C20H18ClF3N4O2/c1-18(20(23,24)19(7-2-8-19)30-17(25)28-18)13-9-12(4-5-14(13)22)27-16(29)15-6-3-11(21)10-26-15/h3-6,9-10H,2,7-8H2,1H3,(H2,25,28)(H,27,29)
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US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258274
PNG
(US9493485, 8-110)
Show SMILES CC#Cc1cncc(c1)-c1csc(c1)[C@]1(C)CC2(CCC(F)(F)CC2)OC(N)=N1
Show InChI InChI=1S/C22H23F2N3OS/c1-3-4-15-9-16(12-26-11-15)17-10-18(29-13-17)20(2)14-21(28-19(25)27-20)5-7-22(23,24)8-6-21/h9-13H,5-8,14H2,1-2H3,(H2,25,27)/t20-/m0/s1
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Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258303
PNG
(US9493485, 9-144)
Show SMILES C[C@]1(CC2(CCC2)SC(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C20H20F2N4OS/c1-19(11-20(7-2-8-20)28-18(23)26-19)14-9-13(4-5-15(14)22)25-17(27)16-6-3-12(21)10-24-16/h3-6,9-10H,2,7-8,11H2,1H3,(H2,23,26)(H,25,27)/t19-/m0/s1
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US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258323
PNG
(US9493485, 9-164)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)C1(C)N=C(N)OC2(CCC2)C1(F)F
Show InChI InChI=1S/C20H20F3N5O3/c1-18(20(22,23)19(6-3-7-19)31-17(24)28-18)12-8-11(4-5-13(12)21)27-16(29)14-9-26-15(30-2)10-25-14/h4-5,8-10H,3,6-7H2,1-2H3,(H2,24,28)(H,27,29)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258301
PNG
(US9493485, 9-142)
Show SMILES CC1(CC2(CCCCC2)SC(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C22H24F2N4OS/c1-21(13-22(30-20(25)28-21)9-3-2-4-10-22)16-11-15(6-7-17(16)24)27-19(29)18-8-5-14(23)12-26-18/h5-8,11-12H,2-4,9-10,13H2,1H3,(H2,25,28)(H,27,29)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258284
PNG
(US9493485, 9-125)
Show SMILES CC1(CC2(CCC2)OC(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C20H20F2N4O2/c1-19(11-20(7-2-8-20)28-18(23)26-19)14-9-13(4-5-15(14)22)25-17(27)16-6-3-12(21)10-24-16/h3-6,9-10H,2,7-8,11H2,1H3,(H2,23,26)(H,25,27)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258306
PNG
(US9493485, 9-147)
Show SMILES CC1(CC2(CCOCC2)SC(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C21H22F2N4O2S/c1-20(12-21(30-19(24)27-20)6-8-29-9-7-21)15-10-14(3-4-16(15)23)26-18(28)17-5-2-13(22)11-25-17/h2-5,10-11H,6-9,12H2,1H3,(H2,24,27)(H,26,28)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258307
PNG
(US9493485, 9-148)
Show SMILES C[C@]1(CC2(CCOCC2)SC(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C21H22F2N4O2S/c1-20(12-21(30-19(24)27-20)6-8-29-9-7-21)15-10-14(3-4-16(15)23)26-18(28)17-5-2-13(22)11-25-17/h2-5,10-11H,6-9,12H2,1H3,(H2,24,27)(H,26,28)/t20-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258267
PNG
(US9493485, 8-103)
Show SMILES CC#Cc1cncc(c1)-c1csc(c1)C1(C)CC2(CCC2)OC(N)=N1
Show InChI InChI=1S/C20H21N3OS/c1-3-5-14-8-15(11-22-10-14)16-9-17(25-12-16)19(2)13-20(6-4-7-20)24-18(21)23-19/h8-12H,4,6-7,13H2,1-2H3,(H2,21,23)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258314
PNG
(US9493485, 9-155)
Show SMILES CC1(N=C(N)OC2(CCOCC2)C1(F)F)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C21H20F4N4O3/c1-19(21(24,25)20(32-18(26)29-19)6-8-31-9-7-20)14-10-13(3-4-15(14)23)28-17(30)16-5-2-12(22)11-27-16/h2-5,10-11H,6-9H2,1H3,(H2,26,29)(H,28,30)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258329
PNG
(US9493485, 13-182)
Show SMILES COc1cccnc1Nc1ccc(F)c(c1)[C@]1(C)CC2(CCOCC2)SC(N)=N1
Show InChI InChI=1S/C21H25FN4O2S/c1-20(13-21(29-19(23)26-20)7-10-28-11-8-21)15-12-14(5-6-16(15)22)25-18-17(27-2)4-3-9-24-18/h3-6,9,12H,7-8,10-11,13H2,1-2H3,(H2,23,26)(H,24,25)/t20-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258312
PNG
(US9493485, 9-153)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CC2(CCOCC2)SC(N)=N1
Show InChI InChI=1S/C21H24FN5O3S/c1-20(12-21(31-19(23)27-20)5-7-30-8-6-21)14-9-13(3-4-15(14)22)26-18(28)16-10-25-17(29-2)11-24-16/h3-4,9-11H,5-8,12H2,1-2H3,(H2,23,27)(H,26,28)/t20-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258324
PNG
(US9493485, 9-165)
Show SMILES Cc1nc(co1)C(=O)Nc1ccc(F)c(c1)C1(C)N=C(N)OC2(CCC2)C1(F)F
Show InChI InChI=1S/C19H19F3N4O3/c1-10-24-14(9-28-10)15(27)25-11-4-5-13(20)12(8-11)17(2)19(21,22)18(6-3-7-18)29-16(23)26-17/h4-5,8-9H,3,6-7H2,1-2H3,(H2,23,26)(H,25,27)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258321
PNG
(US9493485, 9-162)
Show SMILES C[C@@]1(N=C(N)OC2(CCC2)C1(F)F)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F
Show InChI InChI=1S/C21H18F3N5O2/c1-19(21(23,24)20(7-2-8-20)31-18(26)29-19)14-9-13(4-5-15(14)22)28-17(30)16-6-3-12(10-25)11-27-16/h3-6,9,11H,2,7-8H2,1H3,(H2,26,29)(H,28,30)/t19-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258318
PNG
(US9493485, 9-159)
Show SMILES CC1(N=C(N)OC2(CCC2)C1(F)F)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C20H18F4N4O2/c1-18(20(23,24)19(7-2-8-19)30-17(25)28-18)13-9-12(4-5-14(13)22)27-16(29)15-6-3-11(21)10-26-15/h3-6,9-10H,2,7-8H2,1H3,(H2,25,28)(H,27,29)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258316
PNG
(US9493485, 9-157)
Show SMILES C[C@@]1(N=C(N)OC2(CCOCC2)C1(F)F)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C21H20F4N4O3/c1-19(21(24,25)20(32-18(26)29-19)6-8-31-9-7-20)14-10-13(3-4-15(14)23)28-17(30)16-5-2-12(22)11-27-16/h2-5,10-11H,6-9H2,1H3,(H2,26,29)(H,28,30)/t19-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258289
PNG
(US9493485, 9-130)
Show SMILES C[C@]1(CC2(CCC2)OC(N)=N1)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F
Show InChI InChI=1S/C21H20FN5O2/c1-20(12-21(7-2-8-21)29-19(24)27-20)15-9-14(4-5-16(15)22)26-18(28)17-6-3-13(10-23)11-25-17/h3-6,9,11H,2,7-8,12H2,1H3,(H2,24,27)(H,26,28)/t20-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258298
PNG
(US9493485, 9-139)
Show SMILES CC1(CC2(CCOCC2)OC(N)=N1)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F
Show InChI InChI=1S/C22H22FN5O3/c1-21(13-22(31-20(25)28-21)6-8-30-9-7-22)16-10-15(3-4-17(16)23)27-19(29)18-5-2-14(11-24)12-26-18/h2-5,10,12H,6-9,13H2,1H3,(H2,25,28)(H,27,29)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258295
PNG
(US9493485, 9-136)
Show SMILES C[C@]1(CC2(CCC(F)(F)CC2)OC(N)=N1)c1cc(NC(=O)c2ccc(Br)cn2)ccc1F
Show InChI InChI=1S/C22H22BrF3N4O2/c1-20(12-21(32-19(27)30-20)6-8-22(25,26)9-7-21)15-10-14(3-4-16(15)24)29-18(31)17-5-2-13(23)11-28-17/h2-5,10-11H,6-9,12H2,1H3,(H2,27,30)(H,29,31)/t20-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258281
PNG
(US9493485, 9-122)
Show SMILES C[C@]1(CC2(CCOCC2)OC(N)=N1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F
Show InChI InChI=1S/C21H22ClFN4O3/c1-20(12-21(30-19(24)27-20)6-8-29-9-7-21)15-10-14(3-4-16(15)23)26-18(28)17-5-2-13(22)11-25-17/h2-5,10-11H,6-9,12H2,1H3,(H2,24,27)(H,26,28)/t20-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258283
PNG
(US9493485, 9-124)
Show SMILES C[C@]1(CC2(CCC(F)(F)CC2)OC(N)=N1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F
Show InChI InChI=1S/C22H22ClF3N4O2/c1-20(12-21(32-19(27)30-20)6-8-22(25,26)9-7-21)15-10-14(3-4-16(15)24)29-18(31)17-5-2-13(23)11-28-17/h2-5,10-11H,6-9,12H2,1H3,(H2,27,30)(H,29,31)/t20-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258319
PNG
(US9493485, 9-160)
Show SMILES CC1(N=C(N)OC2(CCC2)C1(F)F)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F
Show InChI InChI=1S/C20H18ClF3N4O2/c1-18(20(23,24)19(7-2-8-19)30-17(25)28-18)13-9-12(4-5-14(13)22)27-16(29)15-6-3-11(21)10-26-15/h3-6,9-10H,2,7-8H2,1H3,(H2,25,28)(H,27,29)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258320
PNG
(US9493485, 9-161)
Show SMILES CC1(N=C(N)OC2(CCC2)C1(F)F)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F
Show InChI InChI=1S/C21H18F3N5O2/c1-19(21(23,24)20(7-2-8-20)31-18(26)29-19)14-9-13(4-5-15(14)22)28-17(30)16-6-3-12(10-25)11-27-16/h3-6,9,11H,2,7-8H2,1H3,(H2,26,29)(H,28,30)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258273
PNG
(US9493485, 8-109)
Show SMILES CC#Cc1cncc(c1)-c1csc(c1)C1(C)CC2(CCC(F)(F)CC2)OC(N)=N1
Show InChI InChI=1S/C22H23F2N3OS/c1-3-4-15-9-16(12-26-11-15)17-10-18(29-13-17)20(2)14-21(28-19(25)27-20)5-7-22(23,24)8-6-21/h9-13H,5-8,14H2,1-2H3,(H2,25,27)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258266
PNG
(US9493485, 8-102)
Show SMILES CC#Cc1cncc(c1)-c1csc(c1)C1(C)CC2(CCOCC2)OC(N)=N1
Show InChI InChI=1S/C21H23N3O2S/c1-3-4-15-9-16(12-23-11-15)17-10-18(27-13-17)20(2)14-21(26-19(22)24-20)5-7-25-8-6-21/h9-13H,5-8,14H2,1-2H3,(H2,22,24)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258280
PNG
(US9493485, 9-121)
Show SMILES CC1(CC2(CCOCC2)OC(N)=N1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F
Show InChI InChI=1S/C21H22ClFN4O3/c1-20(12-21(30-19(24)27-20)6-8-29-9-7-21)15-10-14(3-4-16(15)23)26-18(28)17-5-2-13(22)11-25-17/h2-5,10-11H,6-9,12H2,1H3,(H2,24,27)(H,26,28)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258290
PNG
(US9493485, 9-131)
Show SMILES C[C@]1(CC2(CCC2)OC(N)=N1)c1cc(NC(=O)c2ncc(Cl)cc2F)ccc1F
Show InChI InChI=1S/C20H19ClF2N4O2/c1-19(10-20(5-2-6-20)29-18(24)27-19)13-8-12(3-4-14(13)22)26-17(28)16-15(23)7-11(21)9-25-16/h3-4,7-9H,2,5-6,10H2,1H3,(H2,24,27)(H,26,28)/t19-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258275
PNG
(US9493485, 8-111)
Show SMILES CC#Cc1cncc(c1)-c1ccc(F)c(c1)[C@]1(C)CC2(CCC2)OC(N)=N1
Show InChI InChI=1S/C22H22FN3O/c1-3-5-15-10-17(13-25-12-15)16-6-7-19(23)18(11-16)21(2)14-22(8-4-9-22)27-20(24)26-21/h6-7,10-13H,4,8-9,14H2,1-2H3,(H2,24,26)/t21-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258317
PNG
(US9493485, 9-158)
Show SMILES CC1(N=C(N)OC2(CCOCC2)C1(F)F)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F
Show InChI InChI=1S/C21H20ClF3N4O3/c1-19(21(24,25)20(32-18(26)29-19)6-8-31-9-7-20)14-10-13(3-4-15(14)23)28-17(30)16-5-2-12(22)11-27-16/h2-5,10-11H,6-9H2,1H3,(H2,26,29)(H,28,30)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258299
PNG
(US9493485, 9-140)
Show SMILES COc1cc(Cl)ccc1C(=O)Nc1ccc(F)c(c1)[C@]1(C)CC2(CCC2)OC(N)=N1
Show InChI InChI=1S/C22H23ClFN3O3/c1-21(12-22(8-3-9-22)30-20(25)27-21)16-11-14(5-7-17(16)24)26-19(28)15-6-4-13(23)10-18(15)29-2/h4-7,10-11H,3,8-9,12H2,1-2H3,(H2,25,27)(H,26,28)/t21-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258288
PNG
(US9493485, 9-129)
Show SMILES C[C@]1(CC2(CCC2)OC(N)=N1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F
Show InChI InChI=1S/C20H20ClFN4O2/c1-19(11-20(7-2-8-20)28-18(23)26-19)14-9-13(4-5-15(14)22)25-17(27)16-6-3-12(21)10-24-16/h3-6,9-10H,2,7-8,11H2,1H3,(H2,23,26)(H,25,27)/t19-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258287
PNG
(US9493485, 9-128)
Show SMILES C[C@]1(CC2(CCOCC2)OC(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C21H22F2N4O3/c1-20(12-21(30-19(24)27-20)6-8-29-9-7-21)15-10-14(3-4-16(15)23)26-18(28)17-5-2-13(22)11-25-17/h2-5,10-11H,6-9,12H2,1H3,(H2,24,27)(H,26,28)/t20-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258313
PNG
(US9493485, 9-154)
Show SMILES C[C@]1(CC2(CC2)OC(N)=N1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F
Show InChI InChI=1S/C19H18ClFN4O2/c1-18(10-19(6-7-19)27-17(22)25-18)13-8-12(3-4-14(13)21)24-16(26)15-5-2-11(20)9-23-15/h2-5,8-9H,6-7,10H2,1H3,(H2,22,25)(H,24,26)/t18-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258305
PNG
(US9493485, 9-146)
Show SMILES C[C@]1(CC2(COC2)SC(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C19H18F2N4O2S/c1-18(8-19(9-27-10-19)28-17(22)25-18)13-6-12(3-4-14(13)21)24-16(26)15-5-2-11(20)7-23-15/h2-7H,8-10H2,1H3,(H2,22,25)(H,24,26)/t18-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258277
PNG
(US9493485, 8-113)
Show SMILES CC#Cc1cncc(c1)-c1csc(c1)C1(C)CC2(CCOCC2)SC(N)=N1
Show InChI InChI=1S/C21H23N3OS2/c1-3-4-15-9-16(12-23-11-15)17-10-18(26-13-17)20(2)14-21(27-19(22)24-20)5-7-25-8-6-21/h9-13H,5-8,14H2,1-2H3,(H2,22,24)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258318
PNG
(US9493485, 9-159)
Show SMILES CC1(N=C(N)OC2(CCC2)C1(F)F)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C20H18F4N4O2/c1-18(20(23,24)19(7-2-8-19)30-17(25)28-18)13-9-12(4-5-14(13)22)27-16(29)15-6-3-11(21)10-26-15/h3-6,9-10H,2,7-8H2,1H3,(H2,25,28)(H,27,29)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258278
PNG
(US9493485, 8-114)
Show SMILES CC#Cc1cncc(c1)-c1csc(c1)C1(C)N=C(N)OC2(CCOCC2)C1(F)F
Show InChI InChI=1S/C21H21F2N3O2S/c1-3-4-14-9-15(12-25-11-14)16-10-17(29-13-16)19(2)21(22,23)20(28-18(24)26-19)5-7-27-8-6-20/h9-13H,5-8H2,1-2H3,(H2,24,26)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258276
PNG
(US9493485, 8-112)
Show SMILES CC#Cc1cncc(c1)-c1csc(c1)C1(C)CC2(COC2)OC(N)=N1
Show InChI InChI=1S/C19H19N3O2S/c1-3-4-13-5-14(8-21-7-13)15-6-16(25-9-15)18(2)10-19(11-23-12-19)24-17(20)22-18/h5-9H,10-12H2,1-2H3,(H2,20,22)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258282
PNG
(US9493485, 9-123)
Show SMILES C[C@]1(CC2(CCC(F)(F)CC2)OC(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C22H22F4N4O2/c1-20(12-21(32-19(27)30-20)6-8-22(25,26)9-7-21)15-10-14(3-4-16(15)24)29-18(31)17-5-2-13(23)11-28-17/h2-5,10-11H,6-9,12H2,1H3,(H2,27,30)(H,29,31)/t20-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258314
PNG
(US9493485, 9-155)
Show SMILES CC1(N=C(N)OC2(CCOCC2)C1(F)F)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C21H20F4N4O3/c1-19(21(24,25)20(32-18(26)29-19)6-8-31-9-7-20)14-10-13(3-4-15(14)23)28-17(30)16-5-2-12(22)11-27-16/h2-5,10-11H,6-9H2,1H3,(H2,26,29)(H,28,30)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258294
PNG
(US9493485, 9-135)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CC2(CCC2)OC(N)=N1
Show InChI InChI=1S/C20H22FN5O3/c1-19(11-20(6-3-7-20)29-18(22)26-19)13-8-12(4-5-14(13)21)25-17(27)15-9-24-16(28-2)10-23-15/h4-5,8-10H,3,6-7,11H2,1-2H3,(H2,22,26)(H,25,27)/t19-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258279
PNG
(US9493485, 9-120)
Show SMILES CC1(CC2(CCOCC2)OC(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C21H22F2N4O3/c1-20(12-21(30-19(24)27-20)6-8-29-9-7-21)15-10-14(3-4-16(15)23)26-18(28)17-5-2-13(22)11-25-17/h2-5,10-11H,6-9,12H2,1H3,(H2,24,27)(H,26,28)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258297
PNG
(US9493485, 9-138)
Show SMILES Cc1nc(co1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CC2(CCC2)OC(N)=N1
Show InChI InChI=1S/C19H21FN4O3/c1-11-22-15(9-26-11)16(25)23-12-4-5-14(20)13(8-12)18(2)10-19(6-3-7-19)27-17(21)24-18/h4-5,8-9H,3,6-7,10H2,1-2H3,(H2,21,24)(H,23,25)/t18-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258316
PNG
(US9493485, 9-157)
Show SMILES C[C@@]1(N=C(N)OC2(CCOCC2)C1(F)F)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C21H20F4N4O3/c1-19(21(24,25)20(32-18(26)29-19)6-8-31-9-7-20)14-10-13(3-4-15(14)23)28-17(30)16-5-2-12(22)11-27-16/h2-5,10-11H,6-9H2,1H3,(H2,26,29)(H,28,30)/t19-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258285
PNG
(US9493485, 9-126)
Show SMILES C[C@]1(CC2(CCC2)OC(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C20H20F2N4O2/c1-19(11-20(7-2-8-20)28-18(23)26-19)14-9-13(4-5-15(14)22)25-17(27)16-6-3-12(21)10-24-16/h3-6,9-10H,2,7-8,11H2,1H3,(H2,23,26)(H,25,27)/t19-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258284
PNG
(US9493485, 9-125)
Show SMILES CC1(CC2(CCC2)OC(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C20H20F2N4O2/c1-19(11-20(7-2-8-20)28-18(23)26-19)14-9-13(4-5-15(14)22)25-17(27)16-6-3-12(21)10-24-16/h3-6,9-10H,2,7-8,11H2,1H3,(H2,23,26)(H,25,27)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258268
PNG
(US9493485, 8-104)
Show SMILES CC#Cc1cncc(c1)-c1csc(c1)[C@]1(C)CC2(CCOCC2)OC(N)=N1
Show InChI InChI=1S/C21H23N3O2S/c1-3-4-15-9-16(12-23-11-15)17-10-18(27-13-17)20(2)14-21(26-19(22)24-20)5-7-25-8-6-21/h9-13H,5-8,14H2,1-2H3,(H2,22,24)/t20-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258323
PNG
(US9493485, 9-164)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)C1(C)N=C(N)OC2(CCC2)C1(F)F
Show InChI InChI=1S/C20H20F3N5O3/c1-18(20(22,23)19(6-3-7-19)31-17(24)28-18)12-8-11(4-5-13(12)21)27-16(29)14-9-26-15(30-2)10-25-14/h4-5,8-10H,3,6-7H2,1-2H3,(H2,24,28)(H,27,29)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258324
PNG
(US9493485, 9-165)
Show SMILES Cc1nc(co1)C(=O)Nc1ccc(F)c(c1)C1(C)N=C(N)OC2(CCC2)C1(F)F
Show InChI InChI=1S/C19H19F3N4O3/c1-10-24-14(9-28-10)15(27)25-11-4-5-13(20)12(8-11)17(2)19(21,22)18(6-3-7-18)29-16(23)26-17/h4-5,8-9H,3,6-7H2,1-2H3,(H2,23,26)(H,25,27)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258328
PNG
(US9493485, 12-179)
Show SMILES C[C@]1(CC2(CCC2)OC(N)=N1)c1cc(\C=C\c2ccc(Cl)cc2)ccc1F
Show InChI InChI=1S/C22H22ClFN2O/c1-21(14-22(11-2-12-22)27-20(25)26-21)18-13-16(7-10-19(18)24)4-3-15-5-8-17(23)9-6-15/h3-10,13H,2,11-12,14H2,1H3,(H2,25,26)/b4-3+/t21-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258270
PNG
(US9493485, 8-106)
Show SMILES CC1(CC2(CCOCC2)OC(N)=N1)c1cc(ccc1F)-c1cncnc1
Show InChI InChI=1S/C19H21FN4O2/c1-18(11-19(26-17(21)24-18)4-6-25-7-5-19)15-8-13(2-3-16(15)20)14-9-22-12-23-10-14/h2-3,8-10,12H,4-7,11H2,1H3,(H2,21,24)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258278
PNG
(US9493485, 8-114)
Show SMILES CC#Cc1cncc(c1)-c1csc(c1)C1(C)N=C(N)OC2(CCOCC2)C1(F)F
Show InChI InChI=1S/C21H21F2N3O2S/c1-3-4-14-9-15(12-25-11-14)16-10-17(29-13-16)19(2)21(22,23)20(28-18(24)26-19)5-7-27-8-6-20/h9-13H,5-8H2,1-2H3,(H2,24,26)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258293
PNG
(US9493485, 9-134)
Show SMILES C[C@]1(CC2(CCC(F)(F)CC2)OC(N)=N1)c1cc(NC(=O)C2CC2)ccc1F
Show InChI InChI=1S/C20H24F3N3O2/c1-18(11-19(28-17(24)26-18)6-8-20(22,23)9-7-19)14-10-13(4-5-15(14)21)25-16(27)12-2-3-12/h4-5,10,12H,2-3,6-9,11H2,1H3,(H2,24,26)(H,25,27)/t18-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258300
PNG
(US9493485, 9-141)
Show SMILES C[C@]1(CC2(CCC2)OC(N)=N1)c1cc(NC(=O)c2ccc(Cl)cc2)ccc1F
Show InChI InChI=1S/C21H21ClFN3O2/c1-20(12-21(9-2-10-21)28-19(24)26-20)16-11-15(7-8-17(16)23)25-18(27)13-3-5-14(22)6-4-13/h3-8,11H,2,9-10,12H2,1H3,(H2,24,26)(H,25,27)/t20-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258274
PNG
(US9493485, 8-110)
Show SMILES CC#Cc1cncc(c1)-c1csc(c1)[C@]1(C)CC2(CCC(F)(F)CC2)OC(N)=N1
Show InChI InChI=1S/C22H23F2N3OS/c1-3-4-15-9-16(12-26-11-15)17-10-18(29-13-17)20(2)14-21(28-19(25)27-20)5-7-22(23,24)8-6-21/h9-13H,5-8,14H2,1-2H3,(H2,25,27)/t20-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258308
PNG
(US9493485, 9-149)
Show SMILES C[C@@]1(CC2(CCOCC2)SC(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C21H22F2N4O2S/c1-20(12-21(30-19(24)27-20)6-8-29-9-7-21)15-10-14(3-4-16(15)23)26-18(28)17-5-2-13(22)11-25-17/h2-5,10-11H,6-9,12H2,1H3,(H2,24,27)(H,26,28)/t20-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258272
PNG
(US9493485, 8-108)
Show SMILES CC#Cc1cncc(c1)-c1cc(sc1C)[C@]1(C)CC2(CCOCC2)OC(N)=N1
Show InChI InChI=1S/C22H25N3O2S/c1-4-5-16-10-17(13-24-12-16)18-11-19(28-15(18)2)21(3)14-22(27-20(23)25-21)6-8-26-9-7-22/h10-13H,6-9,14H2,1-3H3,(H2,23,25)/t21-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258273
PNG
(US9493485, 8-109)
Show SMILES CC#Cc1cncc(c1)-c1csc(c1)C1(C)CC2(CCC(F)(F)CC2)OC(N)=N1
Show InChI InChI=1S/C22H23F2N3OS/c1-3-4-15-9-16(12-26-11-15)17-10-18(29-13-17)20(2)14-21(28-19(25)27-20)5-7-22(23,24)8-6-21/h9-13H,5-8,14H2,1-2H3,(H2,25,27)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258326
PNG
(US9493485, 12-177)
Show SMILES C[C@]1(CC2(CCC2)OC(N)=N1)c1cc(\C=C\c2ccc(F)cc2)ccc1F
Show InChI InChI=1S/C22H22F2N2O/c1-21(14-22(11-2-12-22)27-20(25)26-21)18-13-16(7-10-19(18)24)4-3-15-5-8-17(23)9-6-15/h3-10,13H,2,11-12,14H2,1H3,(H2,25,26)/b4-3+/t21-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258286
PNG
(US9493485, 9-127)
Show SMILES C[C@@]1(CC2(CCC2)OC(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C20H20F2N4O2/c1-19(11-20(7-2-8-20)28-18(23)26-19)14-9-13(4-5-15(14)22)25-17(27)16-6-3-12(21)10-24-16/h3-6,9-10H,2,7-8,11H2,1H3,(H2,23,26)(H,25,27)/t19-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258269
PNG
(US9493485, 8-105)
Show SMILES CC#Cc1cncc(c1)-c1csc(c1)[C@@]1(C)CC2(CCOCC2)OC(N)=N1
Show InChI InChI=1S/C21H23N3O2S/c1-3-4-15-9-16(12-23-11-15)17-10-18(27-13-17)20(2)14-21(26-19(22)24-20)5-7-25-8-6-21/h9-13H,5-8,14H2,1-2H3,(H2,22,24)/t20-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258267
PNG
(US9493485, 8-103)
Show SMILES CC#Cc1cncc(c1)-c1csc(c1)C1(C)CC2(CCC2)OC(N)=N1
Show InChI InChI=1S/C20H21N3OS/c1-3-5-14-8-15(11-22-10-14)16-9-17(25-12-16)19(2)13-20(6-4-7-20)24-18(21)23-19/h8-12H,4,6-7,13H2,1-2H3,(H2,21,23)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258311
PNG
(US9493485, 9-152)
Show SMILES C[C@@]1(CC2(CCOCC2)SC(N)=N1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F
Show InChI InChI=1S/C21H22ClFN4O2S/c1-20(12-21(30-19(24)27-20)6-8-29-9-7-21)15-10-14(3-4-16(15)23)26-18(28)17-5-2-13(22)11-25-17/h2-5,10-11H,6-9,12H2,1H3,(H2,24,27)(H,26,28)/t20-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258271
PNG
(US9493485, 8-107)
Show SMILES CCCn1cc(cn1)-c1ccc(F)c(c1)C1(C)CC2(CCOCC2)OC(N)=N1
Show InChI InChI=1S/C21H27FN4O2/c1-3-8-26-13-16(12-24-26)15-4-5-18(22)17(11-15)20(2)14-21(28-19(23)25-20)6-9-27-10-7-21/h4-5,11-13H,3,6-10,14H2,1-2H3,(H2,23,25)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258296
PNG
(US9493485, 9-137)
Show SMILES C[C@]1(CC2(CCC(F)(F)CC2)OC(N)=N1)c1cc(NC(=O)c2ccc(cn2)C2CC2)ccc1F
Show InChI InChI=1S/C25H27F3N4O2/c1-23(14-24(34-22(29)32-23)8-10-25(27,28)11-9-24)18-12-17(5-6-19(18)26)31-21(33)20-7-4-16(13-30-20)15-2-3-15/h4-7,12-13,15H,2-3,8-11,14H2,1H3,(H2,29,32)(H,31,33)/t23-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM258277
PNG
(US9493485, 8-113)
Show SMILES CC#Cc1cncc(c1)-c1csc(c1)C1(C)CC2(CCOCC2)SC(N)=N1
Show InChI InChI=1S/C21H23N3OS2/c1-3-4-15-9-16(12-23-11-15)17-10-18(26-13-17)20(2)14-21(27-19(22)24-20)5-7-25-8-6-21/h9-13H,5-8,14H2,1-2H3,(H2,22,24)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258327
PNG
(US9493485, 12-178)
Show SMILES C[C@]1(CC2(CCC(F)(F)CC2)OC(N)=N1)c1cc(\C=C\c2ccc(F)cc2)ccc1F
Show InChI InChI=1S/C24H24F4N2O/c1-22(15-23(31-21(29)30-22)10-12-24(27,28)13-11-23)19-14-17(6-9-20(19)26)3-2-16-4-7-18(25)8-5-16/h2-9,14H,10-13,15H2,1H3,(H2,29,30)/b3-2+/t22-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258266
PNG
(US9493485, 8-102)
Show SMILES CC#Cc1cncc(c1)-c1csc(c1)C1(C)CC2(CCOCC2)OC(N)=N1
Show InChI InChI=1S/C21H23N3O2S/c1-3-4-15-9-16(12-23-11-15)17-10-18(27-13-17)20(2)14-21(26-19(22)24-20)5-7-25-8-6-21/h9-13H,5-8,14H2,1-2H3,(H2,22,24)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258293
PNG
(US9493485, 9-134)
Show SMILES C[C@]1(CC2(CCC(F)(F)CC2)OC(N)=N1)c1cc(NC(=O)C2CC2)ccc1F
Show InChI InChI=1S/C20H24F3N3O2/c1-18(11-19(28-17(24)26-18)6-8-20(22,23)9-7-19)14-10-13(4-5-15(14)21)25-16(27)12-2-3-12/h4-5,10,12H,2-3,6-9,11H2,1H3,(H2,24,26)(H,25,27)/t18-/m0/s1
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n/an/a 2.33E+3n/an/an/an/an/an/a



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258275
PNG
(US9493485, 8-111)
Show SMILES CC#Cc1cncc(c1)-c1ccc(F)c(c1)[C@]1(C)CC2(CCC2)OC(N)=N1
Show InChI InChI=1S/C22H22FN3O/c1-3-5-15-10-17(13-25-12-15)16-6-7-19(23)18(11-16)21(2)14-22(8-4-9-22)27-20(24)26-21/h6-7,10-13H,4,8-9,14H2,1-2H3,(H2,24,26)/t21-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258325
PNG
(US9493485, 10-169)
Show SMILES C[C@]1(CC2(CCC2)OC(N)=N1)c1cc(NCc2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C20H22F2N4O/c1-19(12-20(7-2-8-20)27-18(23)26-19)16-9-14(5-6-17(16)22)25-11-15-4-3-13(21)10-24-15/h3-6,9-10,25H,2,7-8,11-12H2,1H3,(H2,23,26)/t19-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM258266
PNG
(US9493485, 8-102)
Show SMILES CC#Cc1cncc(c1)-c1csc(c1)C1(C)CC2(CCOCC2)OC(N)=N1
Show InChI InChI=1S/C21H23N3O2S/c1-3-4-15-9-16(12-23-11-15)17-10-18(27-13-17)20(2)14-21(26-19(22)24-20)5-7-25-8-6-21/h9-13H,5-8,14H2,1-2H3,(H2,22,24)
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n/an/a 4.43E+3n/an/an/an/an/an/a



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258328
PNG
(US9493485, 12-179)
Show SMILES C[C@]1(CC2(CCC2)OC(N)=N1)c1cc(\C=C\c2ccc(Cl)cc2)ccc1F
Show InChI InChI=1S/C22H22ClFN2O/c1-21(14-22(11-2-12-22)27-20(25)26-21)18-13-16(7-10-19(18)24)4-3-15-5-8-17(23)9-6-15/h3-10,13H,2,11-12,14H2,1H3,(H2,25,26)/b4-3+/t21-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM258275
PNG
(US9493485, 8-111)
Show SMILES CC#Cc1cncc(c1)-c1ccc(F)c(c1)[C@]1(C)CC2(CCC2)OC(N)=N1
Show InChI InChI=1S/C22H22FN3O/c1-3-5-15-10-17(13-25-12-15)16-6-7-19(23)18(11-16)21(2)14-22(8-4-9-22)27-20(24)26-21/h6-7,10-13H,4,8-9,14H2,1-2H3,(H2,24,26)/t21-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM258269
PNG
(US9493485, 8-105)
Show SMILES CC#Cc1cncc(c1)-c1csc(c1)[C@@]1(C)CC2(CCOCC2)OC(N)=N1
Show InChI InChI=1S/C21H23N3O2S/c1-3-4-15-9-16(12-23-11-15)17-10-18(27-13-17)20(2)14-21(26-19(22)24-20)5-7-25-8-6-21/h9-13H,5-8,14H2,1-2H3,(H2,22,24)/t20-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM258278
PNG
(US9493485, 8-114)
Show SMILES CC#Cc1cncc(c1)-c1csc(c1)C1(C)N=C(N)OC2(CCOCC2)C1(F)F
Show InChI InChI=1S/C21H21F2N3O2S/c1-3-4-14-9-15(12-25-11-14)16-10-17(29-13-16)19(2)21(22,23)20(28-18(24)26-19)5-7-27-8-6-20/h9-13H,5-8H2,1-2H3,(H2,24,26)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM258274
PNG
(US9493485, 8-110)
Show SMILES CC#Cc1cncc(c1)-c1csc(c1)[C@]1(C)CC2(CCC(F)(F)CC2)OC(N)=N1
Show InChI InChI=1S/C22H23F2N3OS/c1-3-4-15-9-16(12-26-11-15)17-10-18(29-13-17)20(2)14-21(28-19(25)27-20)5-7-22(23,24)8-6-21/h9-13H,5-8,14H2,1-2H3,(H2,25,27)/t20-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM258273
PNG
(US9493485, 8-109)
Show SMILES CC#Cc1cncc(c1)-c1csc(c1)C1(C)CC2(CCC(F)(F)CC2)OC(N)=N1
Show InChI InChI=1S/C22H23F2N3OS/c1-3-4-15-9-16(12-26-11-15)17-10-18(29-13-17)20(2)14-21(28-19(25)27-20)5-7-22(23,24)8-6-21/h9-13H,5-8,14H2,1-2H3,(H2,25,27)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258286
PNG
(US9493485, 9-127)
Show SMILES C[C@@]1(CC2(CCC2)OC(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C20H20F2N4O2/c1-19(11-20(7-2-8-20)28-18(23)26-19)14-9-13(4-5-15(14)22)25-17(27)16-6-3-12(21)10-24-16/h3-6,9-10H,2,7-8,11H2,1H3,(H2,23,26)(H,25,27)/t19-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258302
PNG
(US9493485, 9-143)
Show SMILES C[C@@]1(CC2(CCC2)SC(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C20H20F2N4OS/c1-19(11-20(7-2-8-20)28-18(23)26-19)14-9-13(4-5-15(14)22)25-17(27)16-6-3-12(21)10-24-16/h3-6,9-10H,2,7-8,11H2,1H3,(H2,23,26)(H,25,27)/t19-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM258267
PNG
(US9493485, 8-103)
Show SMILES CC#Cc1cncc(c1)-c1csc(c1)C1(C)CC2(CCC2)OC(N)=N1
Show InChI InChI=1S/C20H21N3OS/c1-3-5-14-8-15(11-22-10-14)16-9-17(25-12-16)19(2)13-20(6-4-7-20)24-18(21)23-19/h8-12H,4,6-7,13H2,1-2H3,(H2,21,23)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258308
PNG
(US9493485, 9-149)
Show SMILES C[C@@]1(CC2(CCOCC2)SC(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C21H22F2N4O2S/c1-20(12-21(30-19(24)27-20)6-8-29-9-7-21)15-10-14(3-4-16(15)23)26-18(28)17-5-2-13(22)11-25-17/h2-5,10-11H,6-9,12H2,1H3,(H2,24,27)(H,26,28)/t20-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258330
PNG
(US9493485, 11-173)
Show SMILES C[C@]1(CC2(CCC2)OC(N)=N1)c1cc(Nc2ncnc3cc(Cl)ccc23)ccc1F
Show InChI InChI=1S/C22H21ClFN5O/c1-21(11-22(7-2-8-22)30-20(25)29-21)16-10-14(4-6-17(16)24)28-19-15-5-3-13(23)9-18(15)26-12-27-19/h3-6,9-10,12H,2,7-8,11H2,1H3,(H2,25,29)(H,26,27,28)/t21-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258299
PNG
(US9493485, 9-140)
Show SMILES COc1cc(Cl)ccc1C(=O)Nc1ccc(F)c(c1)[C@]1(C)CC2(CCC2)OC(N)=N1
Show InChI InChI=1S/C22H23ClFN3O3/c1-21(12-22(8-3-9-22)30-20(25)27-21)16-11-14(5-7-17(16)24)26-19(28)15-6-4-13(23)10-18(15)29-2/h4-7,10-11H,3,8-9,12H2,1-2H3,(H2,25,27)(H,26,28)/t21-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM258272
PNG
(US9493485, 8-108)
Show SMILES CC#Cc1cncc(c1)-c1cc(sc1C)[C@]1(C)CC2(CCOCC2)OC(N)=N1
Show InChI InChI=1S/C22H25N3O2S/c1-4-5-16-10-17(13-24-12-16)18-11-19(28-15(18)2)21(3)14-22(27-20(23)25-21)6-8-26-9-7-22/h10-13H,6-9,14H2,1-3H3,(H2,23,25)/t21-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM258309
PNG
(US9493485, 9-150)
Show SMILES CC1(CC2(CCOCC2)SC(N)=N1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F
Show InChI InChI=1S/C21H22ClFN4O2S/c1-20(12-21(30-19(24)27-20)6-8-29-9-7-21)15-10-14(3-4-16(15)23)26-18(28)17-5-2-13(22)11-25-17/h2-5,10-11H,6-9,12H2,1H3,(H2,24,27)(H,26,28)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM258311
PNG
(US9493485, 9-152)
Show SMILES C[C@@]1(CC2(CCOCC2)SC(N)=N1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F
Show InChI InChI=1S/C21H22ClFN4O2S/c1-20(12-21(30-19(24)27-20)6-8-29-9-7-21)15-10-14(3-4-16(15)23)26-18(28)17-5-2-13(22)11-25-17/h2-5,10-11H,6-9,12H2,1H3,(H2,24,27)(H,26,28)/t20-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258270
PNG
(US9493485, 8-106)
Show SMILES CC1(CC2(CCOCC2)OC(N)=N1)c1cc(ccc1F)-c1cncnc1
Show InChI InChI=1S/C19H21FN4O2/c1-18(11-19(26-17(21)24-18)4-6-25-7-5-19)15-8-13(2-3-16(15)20)14-9-22-12-23-10-14/h2-3,8-10,12H,4-7,11H2,1H3,(H2,21,24)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258327
PNG
(US9493485, 12-178)
Show SMILES C[C@]1(CC2(CCC(F)(F)CC2)OC(N)=N1)c1cc(\C=C\c2ccc(F)cc2)ccc1F
Show InChI InChI=1S/C24H24F4N2O/c1-22(15-23(31-21(29)30-22)10-12-24(27,28)13-11-23)19-14-17(6-9-20(19)26)3-2-16-4-7-18(25)8-5-16/h2-9,14H,10-13,15H2,1H3,(H2,29,30)/b3-2+/t22-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258322
PNG
(US9493485, 9-163)
Show SMILES C[C@]1(N=C(N)OC2(CCC2)C1(F)F)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F
Show InChI InChI=1S/C21H18F3N5O2/c1-19(21(23,24)20(7-2-8-20)31-18(26)29-19)14-9-13(4-5-15(14)22)28-17(30)16-6-3-12(10-25)11-27-16/h3-6,9,11H,2,7-8H2,1H3,(H2,26,29)(H,28,30)/t19-/m0/s1
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n/an/a 1.34E+4n/an/an/an/an/an/a



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM258329
PNG
(US9493485, 13-182)
Show SMILES COc1cccnc1Nc1ccc(F)c(c1)[C@]1(C)CC2(CCOCC2)SC(N)=N1
Show InChI InChI=1S/C21H25FN4O2S/c1-20(13-21(29-19(23)26-20)7-10-28-11-8-21)15-12-14(5-6-16(15)22)25-18-17(27-2)4-3-9-24-18/h3-6,9,12H,7-8,10-11,13H2,1-2H3,(H2,23,26)(H,24,25)/t20-/m0/s1
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n/an/a 1.47E+4n/an/an/an/an/an/a



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM258268
PNG
(US9493485, 8-104)
Show SMILES CC#Cc1cncc(c1)-c1csc(c1)[C@]1(C)CC2(CCOCC2)OC(N)=N1
Show InChI InChI=1S/C21H23N3O2S/c1-3-4-15-9-16(12-23-11-15)17-10-18(27-13-17)20(2)14-21(26-19(22)24-20)5-7-25-8-6-21/h9-13H,5-8,14H2,1-2H3,(H2,22,24)/t20-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM258306
PNG
(US9493485, 9-147)
Show SMILES CC1(CC2(CCOCC2)SC(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C21H22F2N4O2S/c1-20(12-21(30-19(24)27-20)6-8-29-9-7-21)15-10-14(3-4-16(15)23)26-18(28)17-5-2-13(22)11-25-17/h2-5,10-11H,6-9,12H2,1H3,(H2,24,27)(H,26,28)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM258317
PNG
(US9493485, 9-158)
Show SMILES CC1(N=C(N)OC2(CCOCC2)C1(F)F)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F
Show InChI InChI=1S/C21H20ClF3N4O3/c1-19(21(24,25)20(32-18(26)29-19)6-8-31-9-7-20)14-10-13(3-4-15(14)23)28-17(30)16-5-2-12(22)11-27-16/h2-5,10-11H,6-9H2,1H3,(H2,26,29)(H,28,30)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM258271
PNG
(US9493485, 8-107)
Show SMILES CCCn1cc(cn1)-c1ccc(F)c(c1)C1(C)CC2(CCOCC2)OC(N)=N1
Show InChI InChI=1S/C21H27FN4O2/c1-3-8-26-13-16(12-24-26)15-4-5-18(22)17(11-15)20(2)14-21(28-19(23)25-20)6-9-27-10-7-21/h4-5,11-13H,3,6-10,14H2,1-2H3,(H2,23,25)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM258308
PNG
(US9493485, 9-149)
Show SMILES C[C@@]1(CC2(CCOCC2)SC(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C21H22F2N4O2S/c1-20(12-21(30-19(24)27-20)6-8-29-9-7-21)15-10-14(3-4-16(15)23)26-18(28)17-5-2-13(22)11-25-17/h2-5,10-11H,6-9,12H2,1H3,(H2,24,27)(H,26,28)/t20-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258326
PNG
(US9493485, 12-177)
Show SMILES C[C@]1(CC2(CCC2)OC(N)=N1)c1cc(\C=C\c2ccc(F)cc2)ccc1F
Show InChI InChI=1S/C22H22F2N2O/c1-21(14-22(11-2-12-22)27-20(25)26-21)18-13-16(7-10-19(18)24)4-3-15-5-8-17(23)9-6-15/h3-10,13H,2,11-12,14H2,1H3,(H2,25,26)/b4-3+/t21-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM258285
PNG
(US9493485, 9-126)
Show SMILES C[C@]1(CC2(CCC2)OC(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C20H20F2N4O2/c1-19(11-20(7-2-8-20)28-18(23)26-19)14-9-13(4-5-15(14)22)25-17(27)16-6-3-12(21)10-24-16/h3-6,9-10H,2,7-8,11H2,1H3,(H2,23,26)(H,25,27)/t19-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM258321
PNG
(US9493485, 9-162)
Show SMILES C[C@@]1(N=C(N)OC2(CCC2)C1(F)F)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F
Show InChI InChI=1S/C21H18F3N5O2/c1-19(21(23,24)20(7-2-8-20)31-18(26)29-19)14-9-13(4-5-15(14)22)28-17(30)16-6-3-12(10-25)11-27-16/h3-6,9,11H,2,7-8H2,1H3,(H2,26,29)(H,28,30)/t19-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM258287
PNG
(US9493485, 9-128)
Show SMILES C[C@]1(CC2(CCOCC2)OC(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C21H22F2N4O3/c1-20(12-21(30-19(24)27-20)6-8-29-9-7-21)15-10-14(3-4-16(15)23)26-18(28)17-5-2-13(22)11-25-17/h2-5,10-11H,6-9,12H2,1H3,(H2,24,27)(H,26,28)/t20-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM258313
PNG
(US9493485, 9-154)
Show SMILES C[C@]1(CC2(CC2)OC(N)=N1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F
Show InChI InChI=1S/C19H18ClFN4O2/c1-18(10-19(6-7-19)27-17(22)25-18)13-8-12(3-4-14(13)21)24-16(26)15-5-2-11(20)9-23-15/h2-5,8-9H,6-7,10H2,1H3,(H2,22,25)(H,24,26)/t18-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM258319
PNG
(US9493485, 9-160)
Show SMILES CC1(N=C(N)OC2(CCC2)C1(F)F)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F
Show InChI InChI=1S/C20H18ClF3N4O2/c1-18(20(23,24)19(7-2-8-19)30-17(25)28-18)13-9-12(4-5-14(13)22)27-16(29)15-6-3-11(21)10-26-15/h3-6,9-10H,2,7-8H2,1H3,(H2,25,28)(H,27,29)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258315
PNG
(US9493485, 9-156)
Show SMILES C[C@]1(N=C(N)OC2(CCOCC2)C1(F)F)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C21H20F4N4O3/c1-19(21(24,25)20(32-18(26)29-19)6-8-31-9-7-20)14-10-13(3-4-15(14)23)28-17(30)16-5-2-12(22)11-27-16/h2-5,10-11H,6-9H2,1H3,(H2,26,29)(H,28,30)/t19-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM258297
PNG
(US9493485, 9-138)
Show SMILES Cc1nc(co1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CC2(CCC2)OC(N)=N1
Show InChI InChI=1S/C19H21FN4O3/c1-11-22-15(9-26-11)16(25)23-12-4-5-14(20)13(8-12)18(2)10-19(6-3-7-19)27-17(21)24-18/h4-5,8-9H,3,6-7,10H2,1-2H3,(H2,21,24)(H,23,25)/t18-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM258302
PNG
(US9493485, 9-143)
Show SMILES C[C@@]1(CC2(CCC2)SC(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C20H20F2N4OS/c1-19(11-20(7-2-8-20)28-18(23)26-19)14-9-13(4-5-15(14)22)25-17(27)16-6-3-12(21)10-24-16/h3-6,9-10H,2,7-8,11H2,1H3,(H2,23,26)(H,25,27)/t19-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM258310
PNG
(US9493485, 9-151)
Show SMILES C[C@]1(CC2(CCOCC2)SC(N)=N1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F
Show InChI InChI=1S/C21H22ClFN4O2S/c1-20(12-21(30-19(24)27-20)6-8-29-9-7-21)15-10-14(3-4-16(15)23)26-18(28)17-5-2-13(22)11-25-17/h2-5,10-11H,6-9,12H2,1H3,(H2,24,27)(H,26,28)/t20-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258315
PNG
(US9493485, 9-156)
Show SMILES C[C@]1(N=C(N)OC2(CCOCC2)C1(F)F)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C21H20F4N4O3/c1-19(21(24,25)20(32-18(26)29-19)6-8-31-9-7-20)14-10-13(3-4-15(14)23)28-17(30)16-5-2-12(22)11-27-16/h2-5,10-11H,6-9H2,1H3,(H2,26,29)(H,28,30)/t19-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM258316
PNG
(US9493485, 9-157)
Show SMILES C[C@@]1(N=C(N)OC2(CCOCC2)C1(F)F)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C21H20F4N4O3/c1-19(21(24,25)20(32-18(26)29-19)6-8-31-9-7-20)14-10-13(3-4-15(14)23)28-17(30)16-5-2-12(22)11-27-16/h2-5,10-11H,6-9H2,1H3,(H2,26,29)(H,28,30)/t19-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM258324
PNG
(US9493485, 9-165)
Show SMILES Cc1nc(co1)C(=O)Nc1ccc(F)c(c1)C1(C)N=C(N)OC2(CCC2)C1(F)F
Show InChI InChI=1S/C19H19F3N4O3/c1-10-24-14(9-28-10)15(27)25-11-4-5-13(20)12(8-11)17(2)19(21,22)18(6-3-7-18)29-16(23)26-17/h4-5,8-9H,3,6-7H2,1-2H3,(H2,23,26)(H,25,27)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM258307
PNG
(US9493485, 9-148)
Show SMILES C[C@]1(CC2(CCOCC2)SC(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C21H22F2N4O2S/c1-20(12-21(30-19(24)27-20)6-8-29-9-7-21)15-10-14(3-4-16(15)23)26-18(28)17-5-2-13(22)11-25-17/h2-5,10-11H,6-9,12H2,1H3,(H2,24,27)(H,26,28)/t20-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM258300
PNG
(US9493485, 9-141)
Show SMILES C[C@]1(CC2(CCC2)OC(N)=N1)c1cc(NC(=O)c2ccc(Cl)cc2)ccc1F
Show InChI InChI=1S/C21H21ClFN3O2/c1-20(12-21(9-2-10-21)28-19(24)26-20)16-11-15(7-8-17(16)23)25-18(27)13-3-5-14(22)6-4-13/h3-8,11H,2,9-10,12H2,1H3,(H2,24,26)(H,25,27)/t20-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM258295
PNG
(US9493485, 9-136)
Show SMILES C[C@]1(CC2(CCC(F)(F)CC2)OC(N)=N1)c1cc(NC(=O)c2ccc(Br)cn2)ccc1F
Show InChI InChI=1S/C22H22BrF3N4O2/c1-20(12-21(32-19(27)30-20)6-8-22(25,26)9-7-21)15-10-14(3-4-16(15)24)29-18(31)17-5-2-13(23)11-28-17/h2-5,10-11H,6-9,12H2,1H3,(H2,27,30)(H,29,31)/t20-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM258286
PNG
(US9493485, 9-127)
Show SMILES C[C@@]1(CC2(CCC2)OC(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C20H20F2N4O2/c1-19(11-20(7-2-8-20)28-18(23)26-19)14-9-13(4-5-15(14)22)25-17(27)16-6-3-12(21)10-24-16/h3-6,9-10H,2,7-8,11H2,1H3,(H2,23,26)(H,25,27)/t19-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM258283
PNG
(US9493485, 9-124)
Show SMILES C[C@]1(CC2(CCC(F)(F)CC2)OC(N)=N1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F
Show InChI InChI=1S/C22H22ClF3N4O2/c1-20(12-21(32-19(27)30-20)6-8-22(25,26)9-7-21)15-10-14(3-4-16(15)24)29-18(31)17-5-2-13(23)11-28-17/h2-5,10-11H,6-9,12H2,1H3,(H2,27,30)(H,29,31)/t20-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM258314
PNG
(US9493485, 9-155)
Show SMILES CC1(N=C(N)OC2(CCOCC2)C1(F)F)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C21H20F4N4O3/c1-19(21(24,25)20(32-18(26)29-19)6-8-31-9-7-20)14-10-13(3-4-15(14)23)28-17(30)16-5-2-12(22)11-27-16/h2-5,10-11H,6-9H2,1H3,(H2,26,29)(H,28,30)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM258312
PNG
(US9493485, 9-153)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CC2(CCOCC2)SC(N)=N1
Show InChI InChI=1S/C21H24FN5O3S/c1-20(12-21(31-19(23)27-20)5-7-30-8-6-21)14-9-13(3-4-15(14)22)26-18(28)16-10-25-17(29-2)11-24-16/h3-4,9-11H,5-8,12H2,1-2H3,(H2,23,27)(H,26,28)/t20-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM258303
PNG
(US9493485, 9-144)
Show SMILES C[C@]1(CC2(CCC2)SC(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C20H20F2N4OS/c1-19(11-20(7-2-8-20)28-18(23)26-19)14-9-13(4-5-15(14)22)25-17(27)16-6-3-12(21)10-24-16/h3-6,9-10H,2,7-8,11H2,1H3,(H2,23,26)(H,25,27)/t19-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM258284
PNG
(US9493485, 9-125)
Show SMILES CC1(CC2(CCC2)OC(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C20H20F2N4O2/c1-19(11-20(7-2-8-20)28-18(23)26-19)14-9-13(4-5-15(14)22)25-17(27)16-6-3-12(21)10-24-16/h3-6,9-10H,2,7-8,11H2,1H3,(H2,23,26)(H,25,27)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM258281
PNG
(US9493485, 9-122)
Show SMILES C[C@]1(CC2(CCOCC2)OC(N)=N1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F
Show InChI InChI=1S/C21H22ClFN4O3/c1-20(12-21(30-19(24)27-20)6-8-29-9-7-21)15-10-14(3-4-16(15)23)26-18(28)17-5-2-13(22)11-25-17/h2-5,10-11H,6-9,12H2,1H3,(H2,24,27)(H,26,28)/t20-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM258323
PNG
(US9493485, 9-164)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)C1(C)N=C(N)OC2(CCC2)C1(F)F
Show InChI InChI=1S/C20H20F3N5O3/c1-18(20(22,23)19(6-3-7-19)31-17(24)28-18)12-8-11(4-5-13(12)21)27-16(29)14-9-26-15(30-2)10-25-14/h4-5,8-10H,3,6-7H2,1-2H3,(H2,24,28)(H,27,29)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM258280
PNG
(US9493485, 9-121)
Show SMILES CC1(CC2(CCOCC2)OC(N)=N1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F
Show InChI InChI=1S/C21H22ClFN4O3/c1-20(12-21(30-19(24)27-20)6-8-29-9-7-21)15-10-14(3-4-16(15)23)26-18(28)17-5-2-13(22)11-25-17/h2-5,10-11H,6-9,12H2,1H3,(H2,24,27)(H,26,28)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM258320
PNG
(US9493485, 9-161)
Show SMILES CC1(N=C(N)OC2(CCC2)C1(F)F)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F
Show InChI InChI=1S/C21H18F3N5O2/c1-19(21(23,24)20(7-2-8-20)31-18(26)29-19)14-9-13(4-5-15(14)22)28-17(30)16-6-3-12(10-25)11-27-16/h3-6,9,11H,2,7-8H2,1H3,(H2,26,29)(H,28,30)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM258290
PNG
(US9493485, 9-131)
Show SMILES C[C@]1(CC2(CCC2)OC(N)=N1)c1cc(NC(=O)c2ncc(Cl)cc2F)ccc1F
Show InChI InChI=1S/C20H19ClF2N4O2/c1-19(10-20(5-2-6-20)29-18(24)27-19)13-8-12(3-4-14(13)22)26-17(28)16-15(23)7-11(21)9-25-16/h3-4,7-9H,2,5-6,10H2,1H3,(H2,24,27)(H,26,28)/t19-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM258282
PNG
(US9493485, 9-123)
Show SMILES C[C@]1(CC2(CCC(F)(F)CC2)OC(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C22H22F4N4O2/c1-20(12-21(32-19(27)30-20)6-8-22(25,26)9-7-21)15-10-14(3-4-16(15)24)29-18(31)17-5-2-13(23)11-28-17/h2-5,10-11H,6-9,12H2,1H3,(H2,27,30)(H,29,31)/t20-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM258270
PNG
(US9493485, 8-106)
Show SMILES CC1(CC2(CCOCC2)OC(N)=N1)c1cc(ccc1F)-c1cncnc1
Show InChI InChI=1S/C19H21FN4O2/c1-18(11-19(26-17(21)24-18)4-6-25-7-5-19)15-8-13(2-3-16(15)20)14-9-22-12-23-10-14/h2-3,8-10,12H,4-7,11H2,1H3,(H2,21,24)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM258279
PNG
(US9493485, 9-120)
Show SMILES CC1(CC2(CCOCC2)OC(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C21H22F2N4O3/c1-20(12-21(30-19(24)27-20)6-8-29-9-7-21)15-10-14(3-4-16(15)23)26-18(28)17-5-2-13(22)11-25-17/h2-5,10-11H,6-9,12H2,1H3,(H2,24,27)(H,26,28)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM258288
PNG
(US9493485, 9-129)
Show SMILES C[C@]1(CC2(CCC2)OC(N)=N1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F
Show InChI InChI=1S/C20H20ClFN4O2/c1-19(11-20(7-2-8-20)28-18(23)26-19)14-9-13(4-5-15(14)22)25-17(27)16-6-3-12(21)10-24-16/h3-6,9-10H,2,7-8,11H2,1H3,(H2,23,26)(H,25,27)/t19-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM258289
PNG
(US9493485, 9-130)
Show SMILES C[C@]1(CC2(CCC2)OC(N)=N1)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F
Show InChI InChI=1S/C21H20FN5O2/c1-20(12-21(7-2-8-21)29-19(24)27-20)15-9-14(4-5-16(15)22)26-18(28)17-6-3-13(10-23)11-25-17/h3-6,9,11H,2,7-8,12H2,1H3,(H2,24,27)(H,26,28)/t20-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM258292
PNG
(US9493485, 9-133)
Show SMILES C[C@]1(CC2(CCC(F)(F)CC2)OC(N)=N1)c1cc(NC(=O)c2ncc(Cl)cc2F)ccc1F
Show InChI InChI=1S/C22H21ClF4N4O2/c1-20(11-21(33-19(28)31-20)4-6-22(26,27)7-5-21)14-9-13(2-3-15(14)24)30-18(32)17-16(25)8-12(23)10-29-17/h2-3,8-10H,4-7,11H2,1H3,(H2,28,31)(H,30,32)/t20-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM258294
PNG
(US9493485, 9-135)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]1(C)CC2(CCC2)OC(N)=N1
Show InChI InChI=1S/C20H22FN5O3/c1-19(11-20(6-3-7-20)29-18(22)26-19)13-8-12(4-5-14(13)21)25-17(27)15-9-24-16(28-2)10-23-15/h4-5,8-10H,3,6-7,11H2,1-2H3,(H2,22,26)(H,25,27)/t19-/m0/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM258298
PNG
(US9493485, 9-139)
Show SMILES CC1(CC2(CCOCC2)OC(N)=N1)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F
Show InChI InChI=1S/C22H22FN5O3/c1-21(13-22(31-20(25)28-21)6-8-30-9-7-22)16-10-15(3-4-17(16)23)27-19(29)18-5-2-14(11-24)12-26-18/h2-5,10,12H,6-9,13H2,1H3,(H2,25,28)(H,27,29)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM258304
PNG
(US9493485, 9-145)
Show SMILES C[C@]1(CC2(CCC2)SC(N)=N1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F
Show InChI InChI=1S/C20H20ClFN4OS/c1-19(11-20(7-2-8-20)28-18(23)26-19)14-9-13(4-5-15(14)22)25-17(27)16-6-3-12(21)10-24-16/h3-6,9-10H,2,7-8,11H2,1H3,(H2,23,26)(H,25,27)/t19-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM258305
PNG
(US9493485, 9-146)
Show SMILES C[C@]1(CC2(COC2)SC(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C19H18F2N4O2S/c1-18(8-19(9-27-10-19)28-17(22)25-18)13-6-12(3-4-14(13)21)24-16(26)15-5-2-11(20)7-23-15/h2-7H,8-10H2,1H3,(H2,22,25)(H,24,26)/t18-/m0/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (human))
BDBM258318
PNG
(US9493485, 9-159)
Show SMILES CC1(N=C(N)OC2(CCC2)C1(F)F)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C20H18F4N4O2/c1-18(20(23,24)19(7-2-8-19)30-17(25)28-18)13-9-12(4-5-14(13)22)27-16(29)15-6-3-11(21)10-26-15/h3-6,9-10H,2,7-8H2,1H3,(H2,25,28)(H,27,29)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258271
PNG
(US9493485, 8-107)
Show SMILES CCCn1cc(cn1)-c1ccc(F)c(c1)C1(C)CC2(CCOCC2)OC(N)=N1
Show InChI InChI=1S/C21H27FN4O2/c1-3-8-26-13-16(12-24-26)15-4-5-18(22)17(11-15)20(2)14-21(28-19(23)25-20)6-9-27-10-7-21/h4-5,11-13H,3,6-10,14H2,1-2H3,(H2,23,25)
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n/an/a 3.41E+4n/an/an/an/an/an/a



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258322
PNG
(US9493485, 9-163)
Show SMILES C[C@]1(N=C(N)OC2(CCC2)C1(F)F)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F
Show InChI InChI=1S/C21H18F3N5O2/c1-19(21(23,24)20(7-2-8-20)31-18(26)29-19)14-9-13(4-5-15(14)22)28-17(30)16-6-3-12(10-25)11-27-16/h3-6,9,11H,2,7-8H2,1H3,(H2,26,29)(H,28,30)/t19-/m0/s1
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n/an/a 3.81E+4n/an/an/an/an/an/a



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258302
PNG
(US9493485, 9-143)
Show SMILES C[C@@]1(CC2(CCC2)SC(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C20H20F2N4OS/c1-19(11-20(7-2-8-20)28-18(23)26-19)14-9-13(4-5-15(14)22)25-17(27)16-6-3-12(21)10-24-16/h3-6,9-10H,2,7-8,11H2,1H3,(H2,23,26)(H,25,27)/t19-/m1/s1
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n/an/a 5.18E+4n/an/an/an/an/an/a



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258269
PNG
(US9493485, 8-105)
Show SMILES CC#Cc1cncc(c1)-c1csc(c1)[C@@]1(C)CC2(CCOCC2)OC(N)=N1
Show InChI InChI=1S/C21H23N3O2S/c1-3-4-15-9-16(12-23-11-15)17-10-18(27-13-17)20(2)14-21(26-19(22)24-20)5-7-25-8-6-21/h9-13H,5-8,14H2,1-2H3,(H2,22,24)/t20-/m1/s1
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n/an/a 8.49E+4n/an/an/an/an/an/a



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM258325
PNG
(US9493485, 10-169)
Show SMILES C[C@]1(CC2(CCC2)OC(N)=N1)c1cc(NCc2ccc(F)cn2)ccc1F
Show InChI InChI=1S/C20H22F2N4O/c1-19(12-20(7-2-8-20)27-18(23)26-19)16-9-14(5-6-17(16)22)25-11-15-4-3-13(21)10-24-15/h3-6,9-10,25H,2,7-8,11-12H2,1H3,(H2,23,26)/t19-/m0/s1
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n/an/a 1.79E+5n/an/an/an/an/an/a



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%